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Identificação

Identificação pessoal

Nome completo
Maria Manuel Duque Vieira Marques dos Santos

Nomes de citação

  • Santos, Maria M. M.

Identificadores de autor

Ciência ID
5910-2BF6-5F65
ORCID iD
0000-0002-2239-9353

Endereços de correio eletrónico

  • mariasantos@ff.ulisboa.pt (Profissional)

Telefones

Telefone
  • (+351) 217946451 (Profissional)

Moradas

  • Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa. Avenida Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Exatas - Química - Química Orgânica
Formação
Grau Classificação
2021 - 2022
Concluído
 Pedagogia do Ensino Superior (Pós-Graduação)
Universidade de Lisboa Instituto da Educação, Portugal
2000 - 2004
Concluído
 Chemistry (Organic Synthesis) (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Staurosporine and Analogs - Synthesis of Advanced Precursors" (TESE/DISSERTAÇÃO)
1994 - 1999
Concluído
 Applied Chemistry - Organic chemistry (Licenciatura)
Universidade Nova de Lisboa, Portugal
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/06/15 - 2020/12/30 Investigador principal (carreira) (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/12/16 - 2018/12/15 Investigador Auxiliar (carreira) (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/04 - 2015/04 Investigador visitante (Investigação) Université Nice Sophia Antipolis - Institute of chemistry, França
2008/05/02 - 2013/05/01 Investigador Auxiliar (carreira) (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/02/01 - 2008/04/30 Pós-doutorado (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2004/02/01 - 2006/01/31 Pós-doutorado (Investigação) Universitat de Barcelona Facultat de Farmacia, Espanha
2000/01 - 2004/01 Estagiário de Investigação (Investigação) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1999/09 - 1999/12 Investigador visitante (Investigação) Laboratory of Molecular Catalysis, University Paris-Sud XI , França

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/06 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/01 - 2023/06 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2021/03/29 - Atual Targeting mutant p53 with tryptophanol-derived small molecules (Funding: 249.956,25)
PTDC/QUI-QOR/1304/2020
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2022 - 2026 ITN "Protease-guided tumor targeting tools to revolutionize cancer diagnosis and treatment" (Funding: 2,331,266.4 )
101073231
Orientador
European Commission
2019 - 2022 Bilateral Action Portugal-Hungary, Design and synthesis of hybrid compounds with enhanced anti-tumor potential
SASHJa
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2022 Tackling multidrug resistance in cancer: plant-derived lead compounds as P-glycoptrotein (P-gp) and breast cancer resistant protein (BCRP) modulators and collateral sensitivity agents
PTDC/MED-QUI/30591/2017
Investigador
Fundação para a Ciência e a Tecnologia
Desativado
2018 - 2022 Drug discovery for p53 PPI-targets
PTDC/QUI-QOR/29664/2017
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2022 A new approach to fight tuberculosis: co-drugs activated by mycobacterial esterases
PTDC/SAU-INF/28080/2017
Investigador
Fundação para a Ciência e a Tecnologia
Desativado
2016 - 2019 Targeting p53 family proteins: on the route to new anticancer agents
PTDC/DTP-FTO/1981/2014
Investigador
Fundação para a Ciência e Tecnologia
Desativado
2015 - 2018 New Drugs to Treat Non-alcoholic Fatty Liver and Progression to Cancer
PTDC/BIM-MEC/0895/2014
Investigador
Fundação para a Ciência e Tecnologia
Desativado
2011 - 2014 Functional, molecular and pharmacological studies of p53 family proteins: from yeast to human cells
110848
Provided by PTCRIS: 110848
 Fundação para a Ciência e a Tecnologia
2011 - 2014 Enantioselective synthesis of indole alkaloids and their application as NMDA antagonists
111664
Provided by PTCRIS: 111664
 Fundação para a Ciência e a Tecnologia
2010 - 2014 Diterpenes as lead compounds for overcoming multidrug resistance in cancer cells: P-glycoprotein modulators and antiproliferative agents
99815
Provided by PTCRIS: 99815
 Fundação para a Ciência e a Tecnologia
2011 - 2013 Bilateral Action Portugal-Spain, Enantioselective synthesis of indole alkaloids from chiral lactams
E07/11
Investigador responsável
Concluído

Projeto

Designação Financiadores
2022/04 - 2023/09 Potencial de derivados de ácido nitrobenzóico como fármacos antituberculose. Insights sobre o mecanismo de ação.
Provided by PTCRIS: EXPL/SAU-INF/1097/2021
EXPL/SAU-INF/1097/2021
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2013/07/01 - 2016/02/29 Optimização de moduladores da glicoproteína-P e investigação do mecanismo de efluxo
PTDC/QEQ-MED/0905/2012
Universidade da Madeira, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2013/12/31 Strategic Project - UI 4013 - 2011-2012
PEst-OE/SAU/UI4013/2011
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Elizabeth A. Lopes; Maria M. M. Santos; Mattia Mori. "Antimalarial drugs: what’s new in the patents?". Expert Opinion on Therapeutic Patents (2023): https://doi.org/10.1080/13543776.2023.2203814.
    10.1080/13543776.2023.2203814
  2. Maria M. M. Santos; Ricardo Ferreira; Paulo Anastácio F. Pacheco. Autor correspondente: Maria M. M. Santos. "Reativação da p53 Usando Pequenas Moléculas para Terapia Anticancerígena". Boletim da Sociedade Portuguesa de Química 47 (2023): 30-36. http://dx.doi.org/10.52590/m3.p705.a30002636.
    10.52590/m3.p705.a30002636
  3. Valentina Barcherini; Joana B. Loureiro; Ana Sena; Catarina Madeira; Paula Leandro; Lucília Saraiva; Alexandra M. M. Antunes; Maria M. M. Santos. Autor correspondente: Maria M. M. Santos. "Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators". Pharmaceuticals (2023): https://doi.org/10.3390/ph16020146.
    10.3390/ph16020146
  4. Girst, Gábor; Lopes, Elizabeth A.; Gonçalves, Lídia M.; Espadinha, Margarida; Kúsz, Norbert; Wang, Hui-Chun; Santos, Maria M. M.; Hunyadi, Attila. Autor correspondente: Santos, Maria M. M.. "Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells". RSC Medicinal Chemistry 14 9 (2023): 1778-1786. http://dx.doi.org/10.1039/d3md00251a.
    10.1039/d3md00251a
  5. Espadinha, Margarida; Lopes, Elizabeth A.; Marques, Vanda; Amaral, Joana D.; dos Santos, Daniel J.V.A.; Mori, Mattia; Daniele, Simona; et al. Autor correspondente: Santos, Maria M.M.. "Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors". European Journal of Medicinal Chemistry 241 (2022): 114637. http://dx.doi.org/10.1016/j.ejmech.2022.114637.
    Publicado • 10.1016/j.ejmech.2022.114637
  6. Lopes, Elizabeth A.; Mestre, Raquel; Fontinha, Diana; Legac, Jenny; Pei, Jinxin V.; Sanches-Vaz, Margarida; Mori, Mattia; et al. "Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity". European Journal of Medicinal Chemistry (2022): 114324. http://dx.doi.org/10.1016/j.ejmech.2022.114324.
    10.1016/j.ejmech.2022.114324
  7. Paulo A. F. Pacheco; Maria M. M. Santos. "Recent Progress in the Development of Indole-Based Compounds Active against Malaria, Trypanosomiasis and Leishmaniasis". Molecules (2022): https://doi.org/10.3390/molecules27010319.
    10.3390/molecules27010319
  8. Loureiro, Joana B.; Ribeiro, Rita; Nazareth, Nair; Ferreira, Tiago; Lopes, Elizabeth A.; Gama, Adelina; Machuqueiro, Miguel; et al. "Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis". Pharmacological Research 175 (2022): 106026. http://dx.doi.org/10.1016/j.phrs.2021.106026.
    10.1016/j.phrs.2021.106026
  9. Joana Loureiro; Raimundo L; Juliana Calheiros; Carla Carvalho; Valentina Barcherini; Nuno Lima; Célia Gomes; et al. "Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance". Cancers (2021): https://www.mdpi.com/2072-6694/13/7/1648.
    10.3390/cancers13071648
  10. Margarida Espadinha; Valentina Barcherini; Lídia M. Gonçalves; Elies Molins; Alexandra M. M. Antunes; Maria M. M. Santos. "Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma". Pharmaceuticals 14 3 (2021): 208-208. https://doi.org/10.3390/ph14030208.
    10.3390/ph14030208
  11. Luís R. Raposo; Ana Silva; Dário Silva; Catarina Roma-Rodrigues; Margarida Espadinha; Pedro V. Baptista; Maria M.M. Santos; Alexandra R. Fernandes. "Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line". Bioorganic & Medicinal Chemistry 30 (2021): 115880-115880. https://doi.org/10.1016/j.bmc.2020.115880.
    10.1016/j.bmc.2020.115880
  12. Barcherini, Valentina; Almeida, Joana; Lopes, Elizabeth; Wang, Mi; Silva, Diogo; Mori, Mattia; Wang, Shaomeng; Saraiva, Lucilia; Santos, Maria M. M.. "Potency and selectivity optimization of tryptophanol-derived oxazoloisoindolinones: novel p53 activators in human colorectal cancer". ChemMedChem (2020): http://dx.doi.org/10.1002/cmdc.202000522.
    10.1002/cmdc.202000522
  13. Espadinha, Margarida; Viejo, Lucía; Lopes, Ricardo M.R.M.; Herrera-Arozamena, Clara; Molins, Elies; dos Santos, Daniel J.V.A.; Gonçalves, Lídia; et al. "Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders". European Journal of Medicinal Chemistry 194 (2020): 112242. http://dx.doi.org/10.1016/j.ejmech.2020.112242.
    10.1016/j.ejmech.2020.112242
  14. Helena Ramos; Juliana Calheiros; Joana Almeida; Valentina Barcherini; Sónia Santos; Alexandra T. P. Carvalho; Maria M.M. Santos; Lucília Saraiva. "SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner". International Journal of Molecular Sciences 21 2 (2020): 596-596. https://doi.org/10.3390/ijms21020596.
    10.3390/ijms21020596
  15. Lopes, Elizabeth A.; Gomes, Sara; Saraiva, Lucília; Santos, Maria M.M.. "Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment". Current Medicinal Chemistry 26 41 (2020): 7323-7336. http://dx.doi.org/10.2174/0929867325666181116124308.
    10.2174/0929867325666181116124308
  16. Gomes, Ana Sara; Ramos, Helena; Gomes, Sara; Loureiro, Joana B.; Soares, Joana; Barcherini, Valentina; Monti, Paola; et al. "SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations". Biochimica et Biophysica Acta (BBA) - General Subjects 1864 1 (2020): 129440. http://dx.doi.org/10.1016/j.bbagen.2019.129440.
    10.1016/j.bbagen.2019.129440
  17. Gomes, Sara; Bosco, Bartolomeo; Loureiro, Joana B.; Ramos, Helena; Raimundo, Liliana; Soares, Joana; Nazareth, Nair; et al. "SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma". Cancers 11 8 (2019): 1151. http://dx.doi.org/10.3390/cancers11081151.
    10.3390/cancers11081151
  18. Amaral, Joana D.; Silva, Dário; Rodrigues, Cecília M. P.; Solá, Susana; Santos, Maria M. M.. "A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation". Frontiers in Chemistry 7 (2019): http://dx.doi.org/10.3389/fchem.2019.00015.
    10.3389/fchem.2019.00015
  19. Margarida Espadinha; Nuno M. T. Lourenço; Luis Sobral; Rafael Antunes; Maria M. M. Santos. "A More Sustainable Process for Preparation of the Muscarinic Acetylcholine Antagonist Umeclidinium Bromide". ChemMedChem (2018): https://doi.org/10.1002/cmdc.201800387.
    10.1002/cmdc.201800387
  20. Raimundo, Liliana; Espadinha, Margarida; Soares, Joana; Loureiro, Joana B.; Alves, Marco G.; Santos, Maria M. M.; Saraiva, Lucilia. "Improving anticancer activity towards colon cancer cells with a new p53-activating agent". British Journal of Pharmacology 175 20 (2018): 3947-3962. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000445328600006&KeyUID=WOS:000445328600006.
    10.1111/bph.14468
  21. Espadinha, Margarida; Barcherini, Valentina; Lopes, Elizabeth A.; Santos, Maria M. M.. "An Update on MDMX and Dual MDM2/X Inhibitors". Current Topics in Medicinal Chemistry 18 8 (2018): 647-660. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000441070600002&KeyUID=WOS:000441070600002.
    10.2174/1568026618666180604080119
  22. Soares, J.; Espadinha, M.; Raimundo, L.; Ramos, H.; Gomes, A.S.; Gomes, S.; Loureiro, J.B.; et al. "DIMP53-1: A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties". Molecular Oncology 11 6 (2017): 612-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025616812&partnerID=MN8TOARS.
    10.1002/1878-0261.12051
  23. Ribeiro, C.J.A.; Nunes, R.C.; Amaral, J.D.; Gonçalves, L.M.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties". European Journal of Medicinal Chemistry 140 (2017): 494-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030537870&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.09.037
  24. Nunes, R.C.; Ribeiro, C.J.A.; Monteiro, Â.; Rodrigues, C.M.P.; Amaral, J.D.; Santos, M.M.M.. "In vitro targeting of colon cancer cells using spiropyrazoline oxindoles". European Journal of Medicinal Chemistry 139 (2017): 168-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026814888&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.07.057
  25. Espadinha, M.; Dourado, J.; Lajarin-Cuesta, R.; Herrera-Arozamena, C.; Gonçalves, L.M.D.; Rodríguez-Franco, M.I.; de los Rios, C.; Santos, M.M.M.. "Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists". ChemMedChem 12 7 (2017): 537-545. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016224641&partnerID=MN8TOARS.
    10.1002/cmdc.201700037
  26. Soares, J.; Raimundo, L.; Pereira, N.A.L.; Monteiro, Â; Gomes, S.; Bessa, C.; Pereira, C.; et al. "Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule". Oncotarget 7 4 (2016): 4326-4343. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957991161&partnerID=MN8TOARS.
    10.18632/oncotarget.6775
  27. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirooxadiazoline oxindoles with promising in vitro antitumor activities". MedChemComm 7 3 (2016): 420-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961801651&partnerID=MN8TOARS.
    10.1039/c5md00450k
  28. Pereira, N.A.L.; Sureda, F.X.; Pérez, M.; Amat, M.; Santos, M.M.M.. "Enantiopure indolo[2,3-a]quinolizidines: Synthesis and evaluation as NMDA receptor antagonists". Molecules 21 8 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84983247282&partnerID=MN8TOARS.
    10.3390/molecules21081027
  29. Ribeiro, C.J.A.; Espadinha, M.; Machado, M.; Gut, J.; Gonçalves, L.M.; Rosenthal, P.J.; Prudêncio, M.; Moreira, R.; Santos, M.M.M.. "Novel squaramides with in vitro liver stage antiplasmodial activity". Bioorganic and Medicinal Chemistry 24 8 (2016): 1786-1792. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960971045&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.03.005
  30. Ribeiro, C.J.A.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Chemical variations on the p53 reactivation theme". Pharmaceuticals 9 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84973316044&partnerID=MN8TOARS.
    10.3390/ph9020025
  31. Pereira, N.A.L.; Monteiro, Â.; Machado, M.; Gut, J.; Molins, E.; Perry, M.J.; Dourado, J.; et al. "Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites". ChemMedChem 10 12 (2015): 2080-2089. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951573479&partnerID=MN8TOARS.
    10.1002/cmdc.201500429
  32. Soares, J.; Pereira, N.A.L.; Monteiro, Â.; Leão, M.; Bessa, C.; Dos Santos, D.J.V.A.; Raimundo, L.; et al. "Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction". European Journal of Pharmaceutical Sciences 66 (2015): 138-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908509142&partnerID=MN8TOARS.
    10.1016/j.ejps.2014.10.006
  33. Pérez, M.; Espadinha, M.; Santos, M.M.M.. "Indolo[2,3-a]quinolizidines and derivatives: Bioactivity and asymmetric synthesis". Current Pharmaceutical Design 21 38 (2015): 5518-5546. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957072901&partnerID=MN8TOARS.
    10.2174/1381612821666151002112934
  34. Soares, J.; Raimundo, L.; Pereira, N.A.L.; Dos Santos, D.J.V.A.; Pérez, M.; Queiroz, G.; Leão, M.; Santos, M.M.M.; Saraiva, L.. "A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins". Pharmacological Research 95-96 (2015): 42-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961290684&partnerID=MN8TOARS.
    10.1016/j.phrs.2015.03.006
  35. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents". Bioorganic and Medicinal Chemistry 22 1 (2014): 577-584. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891490447&partnerID=MN8TOARS.
    10.1016/j.bmc.2013.10.048
  36. Pereira, N.A.L.; Sureda, F.X.; Esplugas, R.; Pérez, M.; Amat, M.; Santos, M.M.M.. "Tryptophanol-derived oxazolopiperidone lactams: Identification of a hit compound as NMDA receptor antagonist". Bioorganic and Medicinal Chemistry Letters 24 15 (2014): 3333-3336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904036543&partnerID=MN8TOARS.
    10.1016/j.bmcl.2014.05.105
  37. Monteiro, Â.; Gonçalves, L.M.; Santos, M.M.M.. "Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines". European Journal of Medicinal Chemistry 79 (2014): 266-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898838853&partnerID=MN8TOARS.
    10.1016/j.ejmech.2014.04.023
  38. Santos, M.M.M.. "Recent advances in the synthesis of biologically active spirooxindoles". Tetrahedron 70 52 (2014): 9735-9757. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913545663&partnerID=MN8TOARS.
    10.1016/j.tet.2014.08.005
  39. Santos, DM; Santos, Maria M M; Moreira, Rui; Solá, Susana; Rodrigues, CMP; Santos, D.M.; Santos, M.M.M.; et al. "Synthetic Condensed 1,4-naphthoquinone Derivative Shifts Neural Stem Cell Differentiation by Regulating Redox State". Sem título 47 1 (2013): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872501397&partnerID=MN8TOARS.
    Publicado • 10.1007/s12035-012-8353-y
  40. Pereira, Nuno AL; Sureda, Francesc X; Turch, M; Amat, Mercedes; Bosch, Joan; Santos, Maria MM; Pereira, N.A.L.; et al. "Synthesis of phenylalaninol-derived oxazolopyrrolidone lactams and evaluation as NMDA receptor antagonists". Sem título 144 1 (2013): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879688023&partnerID=MN8TOARS.
    Publicado • 10.1007/s00706-012-0880-8
  41. Reis, Mariana; Ferreira, Ricardo J; Santos, Maria MM; Molnár, J; dos Santos, Daniel JVA; Ferreira, MJU. "Jolkinol D Derivatives as MDR Reversers: Biological Activity, Structure-Activity and Docking Studies". Sem título 1 (2013): 1-10.
    Publicado
  42. Ribeiro, Carlos JA; Kumar, SP; Gut, Jiri; Gonçalves, Lidia M; Rosenthal, Philip J; Moreira, Rui; Santos, Maria MM; et al. "Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents". Sem título 69 1 (2013): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884620898&partnerID=MN8TOARS.
    Publicado • 10.1016/j.ejmech.2013.08.037
  43. Reis, M.; Ferreira, R.J.; Santos, M.M.M.; Dos Santos, D.J.V.A.; Molnár, J.; Ferreira, M.-J.U.. "Enhancing macrocyclic diterpenes as multidrug-resistance reversers: Structure-activity studies on jolkinol D derivatives". Journal of Medicinal Chemistry 56 3 (2013): 748-760. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873898843&partnerID=MN8TOARS.
    10.1021/jm301441w
  44. Amat, M.; Ramos, C.; Pérez, M.; Molins, E.; Florindo, P.; Santos, M.M.M.; Bosch, J.; et al. "Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline". Chemical Communications 49 19 (2013): 1954-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873666887&partnerID=MN8TOARS.
    Publicado • 10.1039/c2cc38540f
  45. Kumar, S Praveen; Glória, Paulo MC; Gonçalves, Lídia M; Gut, Jiri; Rosenthal, Philip J; Moreira, Rui; Santos, Maria MM; et al. "Squaric acid: a valuable scaffold for developing antimalarials?". Sem título 3 1 (2012): 489-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859408800&partnerID=MN8TOARS.
    Publicado • 10.1039/c2md20011b
  46. Ribeiro, C.J.A.; Praveen Kumar, S.; Moreira, R.; Santos, M.M.M.; Ribeiro, Carlos J. A.; Kumar, S. Praveen; Moreira, Rui; Santos, Maria M. M.. "Efficient synthesis of spiroisoxazoline oxindoles". Tetrahedron Letters 53 3 (2012): 281-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-83555174553&partnerID=MN8TOARS.
    Publicado • 10.1016/j.tetlet.2011.10.139
  47. Kumar, S. Praveen; Gut, Jiri; Guedes, Rita C. ; Rosenthal, Philip J.; Santos, Maria M. M.; Moreira, Rui; Praveen Kumar, S.; et al. "Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials". European Journal of Medicinal Chemistry 46 46 (2011): 927-933. http://dx.doi.org/10.1016/j.ejmech.2011.01.008.
    Publicado • 10.1016/j.ejmech.2011.01.008
  48. Glória, Paulo M. C. ; Coutinho, Isabel; Gonçalves, Lídia M.; Baptista, Cristina; Soares, Joana; Newton, Ana S. ; Moreira, Rui; Saraiva, Lucília; Santos, Maria M. M.. "Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway". European Journal of Medicinal Chemistry 46 (2011): 2141-2146.
    Publicado • 10.1016/j.ejmech.2011.02.067
  49. Pérez, Maria; Arioli, Federica; Rigacci, Gianna; Santos, Maria M. M.; Gómez-Esqué, Arantxa; Escolano, Carmen; Florindo, Pedro; et al. "Stereocontrolled Generation of Benzo[a]- and Indolo[2,3-a]quinolizidines from". Sem t�tulo 1 (2011): 3858-3863. http://dx.doi.org/10.1002/ejoc.201100294.
    Publicado
  50. Glória, P.M.C.; Gut, J.; Gonalves, L.M.; Rosenthal, P.J.; Moreira, R.; Santos, M.M.M.; Glória, Paulo M. C. ; et al. "Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents". Bioorganic and Medicinal Chemistry 19 24 (2011): 7635-7642. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255183034&partnerID=MN8TOARS.
    Publicado • 10.1016/j.bmc.2011.10.018
  51. Pérez, M.; Arioli, F.; Rigacci, G.; Santos, M.M.M.; Gõmez-Esqué, A.; Escolano, C.; Florindo, P.; et al. "Stereocontrolled generation of benzo[a]- and indolo[2,3-a]quinolizidines from (S)-tryptophanol and (S)-(3,4-dimethoxyphenyl)alaninol-derived lactams". European Journal of Organic Chemistry 20-21 (2011): 3858-3863. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960295012&partnerID=MN8TOARS.
    10.1002/ejoc.201100294
  52. Santos, Maria M. M.; Faria, Natália; Iley, Jim; Coles, Simon J.; Hursthouse, Michael B.; Martins, M. Luz; Moreira, Rui. "Reaction of Naphthoquinones with Substituted Nitromethanes. Facile Synthesis and antifungal activity of Naphtho[2,3- d]isoxazole-4,9-diones". Bioorganic and Medicinal Chemistry Letters 20 (2010): 193-195.
    Publicado • 10.1016/j.bmcl.2009.10.137
  53. Newton, Ana S. ; Glória, Paulo M. C. ; Gonçalves, Lídia M.; Santos, Daniel J. V. A. dos ; Moreira, Rui; Guedes, Rita C. ; Santos, Maria M. M.. "Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study". European Journal of Medicinal Chemistry 45 (2010): 3858-3863.
    Publicado • 10.1016/j.ejmech.2010.05.039
  54. Castro, Rui E.; Santos, Maria M. M.; Glória, Paulo M. C. ; Ribeiro, Carlos J. A.; Ferreira, Duarte M. S.; Xavier, Joana M.; Moreira, Rui; et al. "Cell Death Targets and Potential Modulators in Alzheimer’s Disease". Current Pharmaceutical Design 16 16 (2010): 2851-2864. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957958533&partnerID=MN8TOARS.
    Publicado
  55. Amat, Mercedes; Gomés-Esqué, Arantxa; Escolano, Carmen; Santos, Maria M. M.; Molins, Elies; Bosch, Joan; Amat, M.; et al. "Enantioselective Formal Synthesis of ( )-Dihydrocorynantheine and (-)-Dihydrocorynantheol". Journal of Organic Chemistry 74 74 (2009): 1205-1211. http://www.scopus.com/inward/record.url?eid=2-s2.0-64549158972&partnerID=MN8TOARS.
    Publicado • 10.1021/jo802387c
  56. Santos, D.M.; Santos, M.M.M.; Viana, R.J.S.; Castro, R.E.; Moreira, R.; Rodrigues, C.M.P.; Santos, Daniela M.; et al. "Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: Potent, non-cytotoxic, antiapoptotic agents". Chemico-Biological Interactions 180 2 (2009): 175-182. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349174541&partnerID=MN8TOARS.
    Publicado • 10.1016/j.cbi.2009.03.007
  57. Santos, Maria M. M.; Newton, Ana S.; Coutinho, Isabel; Gloria, Paulo M. C.; Saraiva, Lucilia; Moreira, Rui. "VINYL SULFONES AS CASPASE INHIBITORS". Drugs of the Future 34 (2009): 176-176.
  58. Amat, Mercedes; Santos, Maria M. M.; Bassas, Oriol; Llor, Núria; Escolano, Carmen; Gomés-Esqué, Arantxa; Molins, Elies; et al. "Straightforward Methodology for the Enantioselective Synthesis of Benzo[a]- and Indolo[2,3-a]quinolizidines". Journal of Organic Chemistry 72 14 (2007): 5193-5201. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447317528&partnerID=MN8TOARS.
    Publicado • 10.1021/jo070539g
  59. Amat, M.; Santos, M.M.M.; Gómez, A.M.; Jokic, D.; Molins, E.; Bosch, J.. "Enantioselective spirocyclizations trom tryptophanol-derived oxazolopiperidone lactams". Organic Letters 9 15 (2007): 2907-2910. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547148914&partnerID=MN8TOARS.
    10.1021/ol0712327
  60. Santos, M.M.M.; Moreira, R.; Santos, Maria M. M.; Moreira, Rui. "Michael acceptors as cysteine protease inhibitors". Mini-Reviews in Medicinal Chemistry 7 10 (2007): 1040-1050. http://www.scopus.com/inward/record.url?eid=2-s2.0-35048878659&partnerID=MN8TOARS.
    Publicado • 10.2174/138955707782110105
  61. Allin, S.M.; Duffy, L.J.; Bulman Page, P.C.; McKee, V.; Edgar, M.; McKenzie, M.J.; Amat, M.; et al. "Complementary routes for the stereoselective synthesis of functionalized benzoquinolizidine targets". Tetrahedron Letters 47 32 (2006): 5713-5716. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745879813&partnerID=MN8TOARS.
    Publicado • 10.1016/j.tetlet.2006.06.035
  62. Amat, Mercedes; Bassas, Oriol; Cantó, Margalida; Llor, Núria; Santos, Maria M. M.; Bosch, Joan. "A convenient synthetic route to 3-acetonyl- and 3-(2-oxoethyl)glutarates". Tetrahedron 61 (2005): 7693-7702.
    Publicado
  63. Amat, M.; Bassas, O.; Cantó, M.; Llor, N.; Santos, M.M.M.; Bosch, J.. "Synthesis of 3-acetonyl- and 3-(2-oxoethyl)glutarates". Tetrahedron 61 32 (2005): 7693-7702. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844454223&partnerID=MN8TOARS.
    10.1016/j.tet.2005.05.084
  64. Bassas, O.; Llor, N.; Santos, M.M.M.; Griera, R.; Molins, E.; Amat, M.; Bosch, J.. "Biogenetically inspired enantioselective approach to indolo[2,3-a]- and benzo[a]quinolizidine alkaloids from a synthetic equivalent of secologanin". Organic Letters 7 14 (2005): 2817-2820. http://www.scopus.com/inward/record.url?eid=2-s2.0-22244448384&partnerID=MN8TOARS.
    10.1021/ol0505609
  65. Santos, Maria M. M.; Lobo, Ana M.; Prabhakar, Sundaresan; Marques, M. Manuel B.; Santos, M.M.M.; Lobo, A.M.; Prabhakar, S.; Marques, M.M.B.. "A new approach to N-protected staurosporinones". Tetrahedron Letters 45 45 (2004): 2347-2349. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242270584&partnerID=MN8TOARS.
    Publicado • 10.1016/j.tetlet.2004.01.089
  66. Gaudêncio, S.P.; Santos, M.M.M.; Lobo, A.M.; Prabhakar, S.; Gaudêncio, Susana P.; Santos, Maria M. M.; Lobo, Ana M.; Prabhakar, Sundaresan. "A short synthesis of staurosporinone (K-252c)". Tetrahedron Letters 44 12 (2003): 2577-2578. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037450946&partnerID=MN8TOARS.
    Publicado • 10.1016/S0040-4039(03)00279-X
  67. Janosik, T.; Bergman, J.; Romero, I.; Stensland, B.; Stålhandske, C.; Marques, M.M.B.; Santos, M.M.M.; et al. "Synthetic, spectroscopic, and X-ray crystallographic studies of [1,2,7,8]tetrathiacyclododecino[4,3-b:5,6-b:10,9-b:11,12-b]tetraindoles". European Journal of Organic Chemistry 8 (2002): 1392-1396. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036224172&partnerID=MN8TOARS.
    10.1002/1099-0690(200204)2002:8<1392::AID-EJOC1392>3.0.CO;2-#
  68. Marques, M. Manuel B.; Santos, Maria M. M.; Lobo, Ana M.; Prabhakar, Sundaresan ; Marques, M.M.B.; Santos, M.M.M.; Lobo, A.M.; Prabhakar, S.. "A novel synthesis of arcyriaflavin-A via an intramolecular sulfur extrusion reaction". Tetrahedron Letters 41 41 (2000): 9835-9838. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034627357&partnerID=MN8TOARS.
    Publicado • 10.1016/S0040-4039(00)01782-2
Capítulo de livro
  1. Santos, Maria Manuel Duque Vieira Marques dos; Lopes, Elizabeth A.. "Synthesis of spirooxindoles by multicomponent reactions". In Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, editado por Faisca Phillips, AMMM, 225-247. Wiley, 2021.
    Publicado
  2. Lopes, Elizabeth A.; Santos, Maria M. M.; Mori, Mattia. "Pharmacological Treatment of Malaria". In Antiprotozoal Drug Development and Delivery, editado por Surupan, Claudiu; Vermelho, A. B., 219-240. Springer International Publishing, 2021.
    10.1007/7355_2021_125
  3. Espadinha, Margarida; Conway, Stuart J.; Santos, Maria M.M.. "PPIs as therapeutic targets for anticancer drug discovery: the case study of MDM2 and BET bromodomain inhibitors". In Small Molecule Drug Discovery, editado por Trabocchi, A.; Lenci, E., 267-288. Elsevier, 2020.
    10.1016/b978-0-12-818349-6.00010-8
  4. Dourado, Jorge; Perez, Maria; Griera, Rosa; Santos, Maria M. M.. "Asymmetric Cyclocondensation Reaction Induced by Chiral Auxiliary". 198-201. Royal Society of Chemistry, 2016.
    Publicado
  5. Ribeiro, Carlos J. A.; Moreira, Rui; Santos, Maria M. M.. "Synthesis of a spiroisoxazoline oxindole by 1,3-dipolar Cycloaddition". 681-684. Royal Society of Chemistry, 2016.
    Publicado
  6. Lopes, F.; Santos, M.M.M.; Moreira, R.. "Designing covalent inhibitors: A medicinal chemistry challenge". In Small Molecule Drug Discovery. 2015.
    10.1515/9783110468755-002
  7. Santos, Maria M. M.; Santos, Maria M. M.. "Tryptophanol-Derived Oxazolopiperidone Lactams: Valuable Building Blocks for the Enantioselective Synthesis of Piperidine-Containing Alkaloids". 69-82. Sem local: Research Signpost, 2011.
    Publicado
Resumo em conferência
  1. Loureiro, Joana B.; Ribeiro, Rita; Nazareth, Nair; Ferreira, Tiago; Quaresma, Adelina; Barcherini, Valentina; Marabini, Laura; et al. "Abstract P030: Chemoprevention by the mutant p53 reactivator SLMP53-2 on ultraviolet radiation-induced skin cancer". 2021.
    Publicado • 10.1158/1535-7163.targ-21-p030

Propriedade Intelectual

Patente
  1. Lourenço, Nuno T.; Sobral, Luis; Antunes, Rafael; Santos, Maria M. M.; Espadinha, Margarida. 2018. "Process for the preparation of Umeclidinium bromide (WO/2018/087561 A1 20180517)".
    Concedida/Emitida
  2. Saraiva, Lucília; Santos, Maria M. M.; Pereira, Nuno A. L.; Pereira, Clara; Moreira, Sara; Leão, Mariana; Monteiro, Ângelo; Soares, Joana. 2016. "Tryptophanol-derived oxazoloisoindolinones: small-molecule p53 activators (WO2014207688A1, US9732091B2, EP3013833B1, PT3013833T)".
    Concedida/Emitida
Distinções

Outra distinção

2018 Member of the International Advisory Board of ChemMedChem (Wiley-VCH)
2018 Member of the Editorial Board of Pharmaceuticals (MDPI)
2016 Nominated as Portuguese NAO Liason officer
2016 Mulheres na Ciência (WOMAN IN SCIENCE)
2015 Nominated a New Talent:Europe by MedChemComm
Royal Society of Canada, Canadá
2015 Portuguese Award for Best Young Organic Chemist 2015
2015 elected member of the EXECUTIVE COMMITTEE of the medicinal chemistry division