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Sandra started her career with a BSc in Chemistry (2008, Univ. of Coimbra, PT) with specialization in chemistry of biological processes, during which she was granted an Erasmus Mundus fellowship, to do part of her studies at the Univ. of Santiago de Compostela, Spain. Here she worked on the synthesis of chelating agents for heavy metal poisoning therapies. She studied a MSc in Organic Chemistry (2010) at the same university, where she started working on the field of organic synthesis applied to the dendritic polymers under the supervision of Dr. E. Fernandez Megía and Prof. R. Riguera. During this time she developed an optimised and scaled-up synthesis of the repeating unit of GATG dendrimers based on green chemistry and atom economy principles. Along with this project she also worked on the preparation of two different families of high generation GATG dendrimers, which have shown excellent results in several biomedical applications. During this time she published an article (Org. Lett. 2011; Q1; IF 6.49), a patent [P201030966 (ES)], 2 oral and 2 poster communications. Afterwards she started the PhD within the same research group (2011, CIQUS/USC) where she got involved in more multidisciplinary projects also including the synthesis of dendrimers but also PEGylated linear and dendritic block-copolymers, including an accelerated synthesis of biodegradable structures prepared using microwave synthesis, click chemistry, and green chemistry principals (article in preparation). The synthesised polymers were used to prepare drug delivery systems (DDS) at the nanoscale such as polymeric micelles and polymersomes with sensitivity to external stimuli such as pH, ionic strength or concentration of bioactive compounds with particular chemical structures. Moreover, she has also worked on the encapsulation of different commercial pharmaceutical drugs such as anticancer agents. She has performed in vitro DD studies and cell experiments to study the internalisation ability of these DDS using fluorescence and confocal microscopy as well as cytotoxicity assays. In collaboration with the Dr. J. Costas and Dr. A. Vidal (CIMUS, USC) they have demonstrated the importance of the size of the DDS in their in vivo biodistribution. This work granted the publication of one very good article (Angew. Chem. Int. Ed. Engl. 2018; Q1; IF 12.1), 2 oral and 2 poster communications, and another article in preparation. Furthermore, in an international collaboration with the Prof. Cameron Alexander (Univ. of Nottingham, UK), they have shown the ability of the polymers developed by her to mediate clustering of bacteria and act as microbicides (Biomaterials Science 2016; Q1; IF 5.8). Before defending the PhD (2017), she moved to the UK where she was part of the science start-up incubator Deep Science Ventures (DSV), which explores science-related ideas from a commercial perspective. Her tasks within the company were to work along other scientists, engineers and business consultants to explore science-related ideas from a commercial perspective, covering areas such as health, sustainability and development of cutting-edge biomaterials. One of the main projects she was involved, focused on the redesign and functionalization of current cellulosic textile fibres for maximization of functions such as fire resistance and recyclability enhancement. After finishing the PhD she decided to take a sabbatical year to work on a non-science related area, and finally, in June 2019 she returned to her home country to start a Postdoc position at ICVS/3B’s research group (Univ. do Minho, PT), which focus on biopolymers, biomimetics and biodegradables for tissue engineering and regenerative medicine applications. Here she currently works along with Dr. Ramón and Dr. Iva Pashkuleva on the synthesis of proteoglycan mimetics for the development of brush-like glycosaminoglycan (GAG) copolymer hydrogels, for the reconstruction of cartilage nanostructures.
Identificação

Identificação pessoal

Nome completo
SANDRA CRISTINA PEREIRA AMARAL

Nomes de citação

  • Amaral, Sandra
  • Amaral, Sandra P.

Identificadores de autor

Ciência ID
4D12-00FC-ED63

Endereços de correio eletrónico

  • sandra.amaral@i3bs.uminho.pt (Profissional)

Websites

  • https://www.linkedin.com/in/sandra-amaral-phd-88768a2b/ (Rede social)

Domínios de atuação

  • Ciências Exatas - Química - Ciência de Polímeros
  • Ciências Exatas - Química - Química Orgânica
  • Ciências da Engenharia e Tecnologias - Nanotecnologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Espanhol; Castelhano Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2019/06/17 - 2021/12/17
Em curso
Postdoctoral Researcher (Pós-doutoramento)
Especialização em Tissue Engineering and Regenerative Medicine
Laboratório Associado ICVS 3B's, Portugal
2017/12/01
Concluído
Doctorado en Ciencia y Tecnología Química (Doctor)
Universidade de Santiago de Compostela, Espanha
"Dendrimers: Accelerated Synthesis, Control of Size and Biodistribution of Micelles" (TESE/DISSERTAÇÃO)
Cum Laude
2010
Concluído
Master en Química Orgánica (Master)
Especialização em Química de Polímeros
Universidade de Santiago de Compostela, Espanha
"Click Chemistry y Polímeros Dendríticos. Preparación de Nanoestructuras Poliméricas." (TESE/DISSERTAÇÃO)
8/10
2008
Concluído
Química (Licenciatura)
Especialização em Química de Processos Biológicos
Universidade de Coimbra, Portugal
14
Percurso profissional

Ciência

2019/06/17 - Atual Investigador Contratado (Investigação)
Universidade do Minho, Portugal
2017/07 - 2017/11 Pós-doutorado (Investigação)
Deep Science Ventures, Reino Unido
Projetos

Projeto

Designação Financiadores
2019 - Atual Reconstruction of Cartilage Nanostructures by Brush Like Copolymers that Mimic Proteoglycans
C491773512-00084360
Investigador
Associação para a Inovação e Desenvolvimento da FCT
2016 - 2017/12/01 Centros de Investigacioín Singulares 2016
ED431G/09
Investigador
Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Espanha
Xunta de Galicia Consellería de Cultura Educacion e Ordenación Universitaria
2014 - 2017/11/30 Nanomaterials and Bioactive Molecules
GRC2014/040
Investigador
Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Espanha
Xunta de Galicia Consellería de Sanidade
2013 - 2015/12/31 PIC (polyion complex) micelles with stability in physiologic conditions as nanosystems for diagnostics and the transport of therapeutic proteins
CTQ2012-34790
Investigador
Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Espanha
Gobierno de España Ministerio de Economía y Empresa
2010 - 2013/09/30 Accelerated processes for the preparation and multifunctionalization of nanodevices for diagnostics and transport of proteins and SI-RNA
10CSA209021PR
Investigador
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
Xunta de Galicia Consellería de Cultura Educacion e Ordenación Universitaria
Produções

Publicações

Artigo em revista
  1. Amaral, Sandra P.; Muna A. Al-Ni'mat; Samuel Parcero-Bouzas; Eduardo Fernandez Megía. "Self-assembly Dendritic Boronate Micelles as a Promising Delivery Strategy for Gemcitabine". ChemRxiv preprint (2020):
    Acesso aberto
  2. Amaral, Sandra P.; Tawara, Maun H.; Fernandez-Villamarin, Marcos; Borrajo, Erea; Martínez-Costas, José; Vidal, Anxo; Riguera, Ricardo; Fernandez-Megia, Eduardo. "Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes". Angewandte Chemie International Edition 57 19 (2018): 5273-5277. http://dx.doi.org/10.1002/anie.201712244.
    Publicado • 10.1002/anie.201712244
  3. Leire, Emma; Amaral, Sandra P.; Louzao, Iria; Winzer, Klaus; Alexander, Cameron; Fernandez-Megia, Eduardo; Fernandez-Trillo, Francisco. "Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability". Biomaterials Science 4 6 (2016): 998-1006. http://dx.doi.org/10.1039/c6bm00079g.
    10.1039/c6bm00079g
  4. Amaral, Sandra P.; Fernandez-Villamarin, Marcos; Correa, Juan; Riguera, Ricardo; Fernandez-Megia, Eduardo. "Efficient Multigram Synthesis of the Repeating Unit of Gallic Acid-Triethylene Glycol Dendrimers". Organic Letters 13 17 (2011): 4522-4525. http://dx.doi.org/10.1021/ol201677k.
    Publicado • 10.1021/ol201677k
Poster em conferência
  1. Novoa-Carballal, Ramón; Amaral, Sandra P.; Valcarcel, Jesus; Gomes, Marisa; Vazquez, Jose Antonio; Carretero, Agatha; Reis, Rui L.; Pashkuleva, Iva. "Multivalent presentation of glycosaminoglycans by their end-on conjugation to star and linear polymers". Trabalho apresentado em 1st Discoveries Forum on Regenerative and Precision Medicine, 2019.
  2. Novoa-Carballal, Ramón; Amaral, Sandra P.; Gomes, Marisa; Valcarcel, Jesus; Vazquez, Jose Antonio; Carretero, Agatha; Reis, Rui L.; Pashkuleva, Iva. "Multivalent Proteoglycan Mimics Generated from Glycosaminoglycans end-on Linked to Star and Linear Polymers". Trabalho apresentado em Term Stem 2019, 2019.
  3. Amaral, Sandra P.; Leire, Emma; Fernandez-Trillo, Francisco; Correa, Juan; Fernandez-Megia, Eduardo. "Multifunctional dendrimers as modular platforms for the development of new generation microbicides". Trabalho apresentado em IV 2015 UKICRS Workshop & Symposium, 2015.
  4. Amaral, Sandra P.; Fernandez-Megia, Eduardo; Riguera, Ricardo. "Design, synthesis and characterization of new GATG dendritic architectures". Trabalho apresentado em Biodendrimer, 2012.
  5. Amaral, Sandra P.; Fernandez-Villamarin, Marcos; Muñoz, Eva; Correa, Juan; Fernandez-Trillo, Francisco; Sousa-Herves, Ana; Novoa-Carballal, Ramón; Riguera, Ricardo; Fernandez-Megia, Eduardo. "GATG Dendrimers: Multivalent nanostructures for biomedical applications". Trabalho apresentado em 2nd International Symposium of the Collaborative Research Center (SFB), 2012.
  6. Amaral, Sandra P.; Fernandez-Villamarin, Marcos; Correa, Juan; Fernandez-Megia, Eduardo; Riguera, Ricardo. "An optimizad protocol for the multigram síntesis of the repeating unit of GATG dendrimers". Trabalho apresentado em 2nd International Symposium of Biological Applications of Dendrimers (Bio-Dendrimers), 2010.
  7. Amaral, Sandra P.; Fernandez-Villamarin, Marcos; Correa, Juan; Fernandez-Megia, Eduardo; Riguera, Ricardo. "Improved and scaled-up síntesis of the repetition unit of GATG dendrimers". Trabalho apresentado em 2do Simposio Iberoamericano de Química Orgánica, 2010.
Tese / Dissertação
  1. Amaral, Sandra P.. "Dendrimers: Accelerated Synthesis, Control of Size and Biodistribution of Micelles". Doutoramento, Centro Singular de Investigación en Química Biológica y Materiales Moleculares, 2017.
  2. Amaral, Sandra P.. "Click Chemistry and Dendritic Polymers. Preparation of Polymeric Nanostructures.". Mestrado, Universidad de Santiago de Compostela Departamento de Química Orgánica, 2010.

Propriedade Intelectual

Patente
  1. Amaral, Sandra; Fernandez-Villamarin, Marcos; Correa, Juan; Riguera, Ricardo; Fernandez-Megia, Eduardo. 2011. "Procedimiento mejorado para la obtención de dendrímeros". Espanha.
    Concedida/Emitida
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2014 Multivalent scale of the repeating unit and synthesis of new dendritic architectures IV Encuentro sobre Dendrímeros EDEN4
Universidad de Santiago de Compostela (Santiago de Compostela, Espanha)
2012 GATG Dendrimers: Multivalent nanostructures for biomedical applications 2nd International Synposium of the Collaborative Research Center (SFB)
SFB (Berlim, Alemanha)
2011 Efficient multigram synthesis of the repeating unit of gallic acid-triethylene glycol dendrimers Dendrimers as composites of advanced drug delivery nano systems (aDDnSs). Biomedical applications.
(Atenas, Grécia)
2010 Dendrímeros GATG: síntese da unidade de repetiçao a grande escala e de novas familias dendríticas XVI Encontro Luso-Galego de Química
Universidade de Aveiro (Aveiro, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2014 - 2014 Membro da comissao organizadora do congresso EDEN4 (2014)
Congresso (Membro da Comissão Organizadora)
Universidade de Santiago de Compostela, Espanha

Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Espanha

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2011/10/04 - 2011/10/09 Participation on the Training School and Workshop "Dendrimers as Composites of Advanced Drug Delivery nano Systems (aDDnDs). Biomedical Applications." organised by within the COST scientific programme on Dendrimers in Biomedical Applications at University of Athens
Oficina (workshop)
Training School and Workshop
Ethniko kai Kapodistriako Panepistemio Athenon, Grécia

Tutoria

Tópico Nome do aluno
2012/10/01 - 2015/10/01 PhD thesis on Multifunctional Dendrimers for Antibacterial Applications Emma Leire
2013/10/01 - 2015/09/30 BSc and MSc thesis "Dendritic Micelles as Drug Delivery Systems for the Transport of Anticancer Drugs" Lucía Álvarez Álvarez
Distinções

Título

2017 "Cum Laude" PhD Dissertation
Universidade de Santiago de Compostela, Espanha

Outra distinção

2011 Training School Grant
Ethniko kai Kapodistriako Panepistemio Athenon, Grécia