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Ana Luisa Carvalho (ORCID 0000-0001-8368-6666) is Associate Professor and group leader at the CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. She has 20 years of experience working as a Neuroscientist. The aim of her research is to uncover cellular and molecular mechanisms at the basis of neuronal excitability and synaptic function, and how they are impaired in brain diseases. She has made important contributions to the identification of receptor associated proteins and metabolic hormones that regulate synaptic function and plasticity, and to understanding synaptic dysfunction in neurodevelopmental disorders. She has published over 65 papers (H index= 33; >3850 citations) in high impact journals such as PNAS, Neuron, Nature Communications and J Cell Biology. Ana Luisa has mentored 17 PhD and 19 MSc students and presently coordinates the H2020-MSCA-ITN European Training Network Syn2Psy-Synaptic Dysfunction in Neuropsychiatric Disorders. She has coordinated 12 research grants funded by FCT, the EU or private foundations, and participated in 18 other grants. She was a member of the Scientific Research Council for FCT (2013-16) and is ad hoc reviewer for ERA-NET; Wellcome Trust, BBSR, MRC (UK), NOW (The Netherlands); Fondation Fondamental and INSERM/CNRS (France); FWO (Belgium); Neurological Foundation of New Zealand; FCT (Portugal), among others. She has given 32 invited conferences and participated in >90 PhD juries and in >110 Master degree juries.
Identificação

Identificação pessoal

Nome completo
Ana Luisa Carvalho
Género
Feminino

Nomes de citação

  • Carvalho, Ana Luisa

Identificadores de autor

Ciência ID
4B1C-1981-B81A
ORCID iD
0000-0001-8368-6666
Google Scholar ID
https://scholar.google.com/citations?user=sY4fkfYAAAAJ&hl=en
Researcher Id
K-6367-2013

Endereços de correio eletrónico

  • alc@cnc.uc.pt (Profissional)

Moradas

  • CNC-Centro de Neurociências e Biologia Celular & Departamento de Ciências da Vida, Universidade de Coimbra. Rua Larga, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • https://www.cnc.uc.pt/en/research-group/synapse-biology (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
1999/04/26
Concluído
Doutoramento em Bioquímica, especialidade de Biologia Molecular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Modulação da actividade dos receptores AMPA por fosforilação: Estudo da fosforilação da subunidade GluR4" (TESE/DISSERTAÇÃO)
Aprovado por unanimidade
1993
Concluído
Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Photoacoustic Measurements of Porphyrin Triplet-State Quantum Yields and Singlet-Oxygen Efficiencies" (TESE/DISSERTAÇÃO)
17 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2009/01/01 - Atual Investigador principal (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/10/01 - 2008/12/31 Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006/09/01 - 2007/08/31 Investigador principal convidado (carreira) (Investigação) The University of British Columbia Department of Psychiatry, Canadá
1999 - 1999 Pós-doutorado (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
1998 - 1998 Estagiário de Investigação (Investigação) Johns Hopkins University School of Medicine, Estados Unidos
Johns Hopkins University School of Medicine, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2019/09/01 - Atual Professor Associado (Docente Universitário) Universidade de Coimbra, Portugal
1999/10/01 - 2019/08/31 Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2019/03/25 - Atual Vice-Presidente Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/10/01 - 2019/08/31 Tenured Assistant Professor Universidade de Coimbra, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2009/01/01 - Atual Group Leader ' Synapse Biology' Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/11/30 - 2021/09 Coordinator of the Master Degree in Cellular and Molecular Biology Universidade de Coimbra, Portugal
2020/03 - 2020/05/31 Volunteer coordinator of COVID-19 diagnosis team - Clinical tests laboratory Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
Projetos

Bolsa

Designação Financiadores
2021 - 2024/11/30 microSTRESS: Regulation of prefrontal cortical synaptic function and behavior by chronic stress-induced microRNA-186-5p
HR21-01077
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Iniciativa Ibérica de Investigaçao e Inovaçao Biomédica, i4b, laCaixa Foundation/FCT
Em curso
2021 - 2024 Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization
PTDC/BIA-CEL/2286/2020
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2020 - 2023/11/30 MStar - Potassium channel dysfunction in models of neurodevelopmental disorders
HR20-00904
Investigador responsável
Iniciativa Ibérica de Investigaçao e Inovaçao Biomédica, i4b, laCaixa Foundation/FCT
Em curso
2019 - 2023/02 Syn2Psy-Synaptic Dysfunction in Neuropsychiatric Disorders
H2020-MSCA-ITN-2018 (813986)
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Commission
Em curso
2018 - 2021/06 COGNITIVE DISORDERS AS DEFECTS IN SYNAPTIC FUNCTION: INSIGHT FROM HUMAN MUTATIONS IN THE CACNG2 GENE
PTDC/MED-NEU/28541/2017
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021/05 Understanding the pathogenesis in CASPR2-antibody autoimmune synaptic encephalitis
PTDC/MED-NEU/29452/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 Molecular tools for Machado-Joseph disease: chaperoning toxic protein conformers in polyglutamine-containing proteins
PTDC/BIA-BFS/31173/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 Alternate SNAPs in neurotransmitter release: from molecular function to neurocognitive dysfunction
PTDC/BIA-CEL/29451/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2017 - 2020 BrainHealth2020
CENTRO-01-0145-FEDER-000008:BrainHealth 2020
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Regional Development Fund
Em curso
2016 - 2018 A role for Contactin-associated proteins 1 and 2 in experience-dependent plasticity
PTDC/NEU-NMC/4888/2014
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2018 BEHAVIOR ANALYSES OF MICE EXPRESSING A CACNG2 MUTATION ASSOCIATED WITH INTELLECTUAL DISABILITY
1530
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fondation Jérôme Lejeune
Concluído
2015 - 2018 Schizophrenia as a disruption of developmental homeostatic plasticity: a role for stargazin
23151
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Brain and Behavior Research Foundation
Concluído
2015 - 2018 StrokeTherapy - Plataformas terapêuticas para acidentes vasculares cerebrais
3386
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Development Fund
2013 - 2015/11 Effects of the orexigenic peptide ghrelin on glutamatergic synaptic transmission
Provided by PTCRIS: 125955
PTDC/NEU-NMC/1098/2012
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014 - 2015/09 Hunger wisdom: ghrelin modulation of adult neurogenesis and its relationship with memory
Provided by PTCRIS: 134218
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2015/09 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
Provided by PTCRIS: 135805
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2015/09 A Novel Model for Schizophrenia: Defects in Stargazin-Mediated Homeostatic Plasticity.
Provided by PTCRIS: 125355
PTDC/NEU-NMC/0750/2012
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2014/06 Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease
Provided by PTCRIS: 110602
PTDC/SAU-NMC/110602/2009
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2013/12 Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type
Provided by PTCRIS: 99440
PTDC/SAU-NEU/099440/2008
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2013/06 Regulation of the stability of the messenger RNA for the GluR1 subunit of glutamate receptors
Provided by PTCRIS: 113738
PTDC/BIA-BCM/113738/2009
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2011/12 Implementation of a Nacional Facility for DNA Microarrays: Phase II
Provided by PTCRIS: 64745
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2011/03 Role of cortactin in the cellular trafficking of AMPA-type glutamate receptors
Provided by PTCRIS: 71789
PTDC/BIA-BCM/71789/2006
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2010/12 Regulation of AMPA receptors by hyperglycemia in the retina
Provided by PTCRIS: 71228
PTDC/SAU-NEU/671228/2006
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2010/04 Cleavage of the vesicular glutamate (VGLUT) and GABA (VGAT) transporters under excitotoxic conditions: identification of the cleavage sites and functional implications
Provided by PTCRIS: 65846
PTDC/SAU-NEU/65846/2006
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005 - 2008/12 Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph´s disease
Provided by PTCRIS: 60156
POCI/SAU-MMO/60156/2004
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2008 Molecular mechanisms coupling Ca2+-permeable AMPA receptors to excitotoxic signalling pathways
NA
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Biogen Portugal
Concluído
2005 - 2007/12 Driving AMPA receptors into synapses: role of interacting proteins in the delivery of GluR4- and GluR2L-containing AMPA receptors
Provided by PTCRIS: 58955
POCI/SAU-NEU/58955/2004
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2003 - 2007 Regulation of the expression of ionotropic glutamate receptors by brain-derived neurotrophic factor (BDNF) in hippocampal neurons
info:eu-repo/grantAgreement/FCT/POCI/46466/PT
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2002 - 2004 Expression and functional characterization of naturally occuring truncated forms of AMPA-type glutamate receptor subunits
POCTI/MGI/43629/2001
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2000 - 2004 Protective effects of neurotrophins against glutamate toxicity in the hippocampus: intracellular signaling mechanisms
info:eu-repo/grantAgreement/FCT/POCI/32631/PT
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2021 - 2025/12/31 DYNABrain - DYNAMIC BRAIN FUNCTION: Towards the Understanding and Treatment of Brain Disorders
952422
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Commission
Produções

Publicações

Artigo em revista
  1. Caldeira, G. L.; Inácio, A. S.; Beltrão, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, T.; Macedo, R.; et al. "Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". Molecular Psychiatry (2022): http://dx.doi.org/10.1038/s41380-022-01487-w.
    10.1038/s41380-022-01487-w
  2. Ana Luisa Carvalho; Dominique Fernandes. "It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling". PLOS Biology (2021): https://doi.org/10.1371/journal.pbio.3001448.
    10.1371/journal.pbio.3001448
  3. Joana S. Ferreira; Blanka Kellermayer; Ana Luísa Carvalho; Laurent Groc. "Interplay between NMDA receptor dynamics and the synaptic proteasome". European Journal of Neuroscience 54 6 (2021): 6000-6011. https://doi.org/10.1111/ejn.15427.
    10.1111/ejn.15427
  4. Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al. "Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation". Science Signaling 14 670 (2021): eabb1953. http://dx.doi.org/10.1126/scisignal.abb1953.
    Acesso aberto • 10.1126/scisignal.abb1953
  5. Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al. "Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-09382-9.
    10.1038/s41467-019-09382-9
  6. Mariline M. Silva; Beatriz Rodrigues; Joana Fernandes; Sandra D. Santos; Laura Carreto; Manuel A. S. Santos; Paulo Pinheiro; et al. "MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons". Proceedings of the National Academy of Sciences 116 12 (2019): 5727-5736. https://doi.org/10.1073/pnas.1900338116.
    Publicado • 10.1073/pnas.1900338116
  7. Dominique Fernandes; Sandra D Santos; Ester Coutinho; Jessica L Whitt; Nuno Beltrão; Tiago Rondão; M Isabel Leite; et al. "Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2". Cerebral Cortex (2019): https://doi.org/10.1093/cercor/bhz032.
    10.1093/cercor/bhz032
  8. Serrenho, D.; Santos, S.D.; Carvalho, A.L.. "The role of ghrelin in regulating synaptic function and plasticity of feeding-associated circuits". Frontiers in Cellular Neuroscience 13 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068476880&partnerID=MN8TOARS.
    10.3389/fncel.2019.00205
  9. Lima Caldeira, G.; Peça, J.; Carvalho, A.L.. "New insights on synaptic dysfunction in neuropsychiatric disorders". Current Opinion in Neurobiology 57 (2019): 62-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061115086&partnerID=MN8TOARS.
    10.1016/j.conb.2019.01.004
  10. Morató, X.; Luján, R.; Gonçalves, N.; Watanabe, M.; Altafaj, X.; Carvalho, A.L.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F.. "Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation". Human Molecular Genetics 27 20 (2018): 3528-3541. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS.
    10.1093/hmg/ddy264
  11. Louros, S.R.; Caldeira, G.L.; Carvalho, A.L.. "Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses". Frontiers in Molecular Neuroscience 11 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85054810796&partnerID=MN8TOARS.
    10.3389/fnmol.2018.00328
  12. Kellermayer, B.; Ferreira, J.S.; Dupuis, J.; Levet, F.; Grillo-Bosch, D.; Bard, L.; Linarès-Loyez, J.; et al. "Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses". Neuron 100 1 (2018): 106-119.e7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054706658&partnerID=MN8TOARS.
    10.1016/j.neuron.2018.09.012
  13. Dominique Fernandes; Ana Luísa Carvalho. "Mechanisms of homeostatic plasticity in the excitatory synapse". Journal of Neurochemistry (2016): http://dx.doi.org/10.1111/jnc.13687.
    10.1111/jnc.13687
  14. Carlos B. Duarte; Ana Luisa Carvalho. "7th ISN special neurochemistry conference ‘Synaptic function and dysfunction in brain diseases’". Journal of Neurochemistry (2016): http://dx.doi.org/10.1111/jnc.13839.
    10.1111/jnc.13839
  15. Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al. "Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia". Neurobiology of Disease 89 (2016): 223-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS.
    10.1016/j.nbd.2015.11.007
  16. Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L.. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models". Journal of Cell Biology 212 4 (2016): 465-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS.
    10.1083/jcb.201506025
  17. Caldeira, Margarida; Ferreira, Joana; Carvalho, Ana; Duarte, Carlos. "Biotinylation and Purification of Plasma Membrane-associated Proteins from Rodent Cultured Neurons". BIO-PROTOCOL 6 10 (2016): http://dx.doi.org/10.21769/bioprotoc.1807.
    10.21769/bioprotoc.1807
  18. Ferreira, J.S.; Schmidt, J.; Rio, P.; Águas, R.; Rooyakkers, A.; Li, K.W.; Smit, A.B.; Craig, A.M.; Carvalho, A.L.. "GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome". Journal of Neuroscience 35 22 (2015): 8462-8479. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930427217&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3567-14.2015
  19. Ferreira, I.L.; Ferreiro, E.; Schmidt, J.; Cardoso, J.M.; Pereira, C.M.F.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C.. "Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release". Neurobiology of Aging 36 2 (2015): 680-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922927392&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2014.09.006
  20. Almeida, B.; Abreu, I.A.; Matos, C.A.; Fraga, J.S.; Fernandes, S.; Macedo, M.G.; Gutiérrez-Gallego, R.; et al. "SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 9 (2015): 1950-1959. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955513053&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.06.010
  21. Ribeiro, L.F.; Catarino, T.; Santos, S.D.; Benoist, M.; Van Leeuwen, J.F.; Esteban, J.A.; Carvalho, A.L.. "Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus". Proceedings of the National Academy of Sciences of the United States of America 111 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891958005&partnerID=MN8TOARS.
    10.1073/pnas.1313798111
  22. Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F.. "Diabetes causes transient changes in the composition and phosphorylation of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina". Molecular Vision 20 (2014): 894-907. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903118075&partnerID=MN8TOARS.
  23. Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E.. "In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons". PLoS ONE 9 6 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS.
    10.1371/journal.pone.0099958
  24. Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al. "Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3". Neurobiology of Disease 68 (2014): 26-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS.
    10.1016/j.nbd.2014.04.002
  25. Louros, S.; Hooks, B.; Litvina, L.; Carvalho, A.; Chen, C.. "A role for stargazin in experience-dependent plasticity". Cell Reports 7 5 (2014): 1614-1625. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902344846&partnerID=MN8TOARS.
    10.1016/j.celrep.2014.04.054
  26. Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C.. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway". Experimental Neurology 261 (2014): 698-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS.
    10.1016/j.expneurol.2014.07.023
  27. Catarino, T.; Ribeiro, L.; Santos, S.D.; Carvalho, A.L.. "Regulation of synapse composition by protein acetylation: The role of acetylated cortactin". Journal of Cell Science 126 1 (2013): 149-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875621271&partnerID=MN8TOARS.
    10.1242/jcs.110742
  28. She, Kevin; Ferreira, Joana S.; Carvalho, Ana Luisa; Craig, Ann Marie. "Glutamate Binding to the GluN2B Subunit Controls Surface Trafficking of N-Methyl-D-aspartate (NMDA) Receptors". Journal of Biological Chemistry 287 33 (2012): 27432-27445.
    10.1074/jbc.M112.345108
  29. Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F.. "Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus". Neuroscience 219 (2012): 23-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864022057&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2012.05.056
  30. Santos, S.D.; Iuliano, O.; Ribeiro, L.; Veran, J.; Ferreira, J.S.; Rio, P.; Mulle, C.; Duarte, C.B.; Carvalho, A.L.. "Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors". Journal of Biological Chemistry 287 9 (2012): 6868-6877. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857468361&partnerID=MN8TOARS.
    10.1074/jbc.M111.322909
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  48. Gomes, A.R.; Correia, S.S.; Esteban, J.A.; Duarte, C.B.; Carvalho, A.L.. "PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression". Traffic 8 3 (2007): 259-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247490214&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2006.00521.x
  49. Cortes, L.; Carvalho, A.L.; Todo-Bom, A.; Faro, C.; Pires, E.; Veríssimo, P.. "Purification of a novel aminopeptidase from the pollen of Parietaria judaica that alters epithelial integrity and degrades neuropeptides". Journal of Allergy and Clinical Immunology 118 4 (2006): 878-884. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749349447&partnerID=MN8TOARS.
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  50. Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L.. "Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor". Cell Death and Differentiation 13 4 (2006): 652-660. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS.
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  51. Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso De Lima, M.C.. "Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three independent signals". Journal of Virology 80 3 (2006): 1393-1404. http://www.scopus.com/inward/record.url?eid=2-s2.0-31144441675&partnerID=MN8TOARS.
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  52. Gomes, A.R.; Cunha, P.; Nuriya, M.; Faro, C.J.; Huganir, R.L.; Pires, E.V.; Carvalho, A.L.; Duarte, C.B.. "Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: Effect on GluR4 phosphorylation and surface expression". Journal of Neurochemistry 90 3 (2004): 673-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342901599&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2004.02519.x
  53. Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Simões, S.; De Lima, M.C.P.. "Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities". Journal of Virology 78 18 (2004): 9731-9739. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444281591&partnerID=MN8TOARS.
    10.1128/JVI.78.18.9731-9739.2004
  54. Fernandes, R.; Carvalho, A.L.; Kumagai, A.; Seica, R.; Hosoya, K.-I.; Terasaki, T.; Murta, J.; Pereira, P.; Faro, C.. "Downregulation of retinal GLUT1 in diabetes by ubiquitinylation". Molecular Vision 10 (2004): 618-628. http://www.scopus.com/inward/record.url?eid=2-s2.0-16544391719&partnerID=MN8TOARS.
  55. Gomes, A.R.; Correia, S.S.; Carvalho, A.L.; Duarte, C.B.. "Regulation of AMPA receptor activity, synaptic targeting and recycling: Role in synaptic plasticity". Neurochemical Research 28 10 (2003): 1459-1473. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141705374&partnerID=MN8TOARS.
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Capítulo de livro
  1. Carvalho, A.L.; Silva, A.; Macedo-Ribeiro, S.. "Polyglutamine-independent features in ataxin-3 aggregation and pathogenesis of Machado-Joseph disease". Springer New York, 2018.
    10.1007/978-3-319-71779-1_14
  2. Vieira, M.M.; Carvalho, A.L.. "Necroptosis in cerebral ischemia". In Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms: Second Edition, 133-151. 2018.
  3. Carvalho, Ana Luisa; Santos, Sandra D.. "Glutamato". In Neurociências. Portugal: LIDEL, 2017.
    Publicado
  4. Carvalho, Ana Luisa; Santos, Sandra D.; Ferreira, Joana S. "Plasticidade sináptica". In Neurociências. Portugal: LIDEL, 2017.
    Publicado
  5. Carvalho, Ana Luisa; Caldeira, Gladys; Peça, João. "Esquizofrenia". In Neurociências, 39-72. Portugal: LIDEL, 2017.
    Publicado
  6. Ribeiro, S.M.-.; Almeida, L.P.D.; Carvalho, A.L.; Rego, A.C.. "Polyglutamine expansion diseases - The case of machado-joseph disease". In Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms: Second Edition. 2007.
    10.1007/978-0-387-70830-0_18
  7. CARVALHO, AP; FERREIRA, IL; CARVALHO, AL; DUARTE, CB; Abood, LG; Lajtha, A. "GLUTAMATE-RECEPTOR MODULATION OF [H-3] GABA RELEASE AND INTRACELLULAR CALCIUM IN CHICK RETINA CELLS". 439-456. 1995.
    10.1111/j.1749-6632.1995.tb17504.x
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/12/06 Aberrant hippocampal transmission and behaviour in mice with a stargazin mutation linked to intellectual disability Mini-Symposium IINS - University of Bordeaux
Daniel Choquet (Bordeaux, França)
2021/10/04 Aberrant hippocampal transmission and behaviour in mice with a stargazin mutation linked to intellectual disability “CURRENT TRENDS IN BIOMEDICINE” - THE SYNAPTIC DIMENSION OF BRAIN DISORDERS
Universidad Internacional de Andalucia (Baeza, Espanha)
2021/07/05 Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation POST-TRANSLATIONAL MODIFICATIONS IN NEURONAL PHYSIOLOGY AND BRAIN DISORDERS
HUMANITAS Research Hospital/ National Research Council of Italy (Itália)
2020/11/11 AMPA receptor dysfunction in cognitive disorders CEDOC Seminar Series, NOVA University
Cláudia Almeida (Lisbon, Portugal)
2020/09 AMPA receptor dysfunction in congnitive disorders World Wide Neuro - Virtual Events in Neuroscience (https://www.world-wide.org/Neuro/)
Gaia Novarino
2020/01/29 AMPA receptor dysfunction in cognitive disorders European Neuroscience Institute (ENI) Seminar Series
Ira Milosevic (Göttingen, Alemanha)
2019/03 AMPA receptor dysfunction in cognitive disorders Centre for Discovery Brain Sciences Seminar Series, University of Edimburgh
Emily Osterweil (Edimburgh, Reino Unido)
2019/02 Synaptic dysfunction in neuropsychiatric disorders iBiMED Seminar Series, University of Aveiro
Ramiro Almeida (Aveiro, Portugal)
2018/09 Synaptic dysfunction in neuropsychiatric disorders 1st Retreat of the Neurobiology and Neurologic Disorders Integrative Program, I3S, University of Porto
João Relvas (Porto, Portugal)
2017/12 AMPA receptor dysfunction in cognitive disorders 6th European Synapse Meeting
European Synapse Meeting (Milan, Itália)
2017/10 Cognitive disorders as defects in synaptic function: insight from human mutations in the CACNG2 gene FEBS3+ - 1st Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies
(Barcelona, Espanha)
2016/06 Cell adhesion contactin-associated proteins mediate homeostatic experience-dependent synaptic plasticity 7th ISN meeting "Synaptic function and dysfunction in brain diseases
International Society for Neurochemistry (Coimbra, Portugal)
2016/03 Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models 10th World Congress on Controversies in Neurology (CONy)
CONy (Lisbon, Portugal)
2015/10 Molecular Mechanisms for Regulating Excitatory Synapses Seminar Series at the Departamento di Neuroscienze, School of Medicine, University of Naples "Federico II"
Lorella Canzoniero (Naples, Itália)
2015/05 Receptors, synapses and memory IBMC-Instituto de Biologia Molecular e Celular, University
Sandra Macedo-Ribeiro (Porto)
2015/04 Molecular Mechanisms for Regulating Excitatory Synapses Seminar Series IDIBELL-Bellvitge Institute for Biomedical Research
Jordi Llorens (Barcelona, Espanha)
2015/01 Mechanisms of glutamate receptor traffic Seminar Series Champalimaud Foundation
Inbal Israely (Lisbon)
2014/12 NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome Seminar Series Interdisciplinary Neuroscience Institute
Nathalie Sans (Bordeaux, França)
2013/05 Modulation of hippocampal glutamatergic synapses by ghrelin XIII Reunião da Sociedade Portuguesa de Neurociências (SPN)
Sociedade Portuguesa de Neurociências (Luso, Portugal)
2013/04 Modulation of hippocampal glutamatergic synapses by ghrelin British Neuroscience Association (BNA) Meeting
British Neuroscience Association (BNA) (London, Reino Unido)
2013/02 Modulators of glutamatergic synapses in the hippocampus Seminar Series IMM-Instituto Medicina Molecular, Universidade de Lisboa
IMM-Instituto Medicina Molecular, Universidade de Lisboa (Lisbon, Portugal)
2012/11 Modulation of hippocampal glutamatergic synapses by ghrelin Seminar Series Interdisciplinary Neuroscience Institute
Interdisciplinary Neuroscience Institute (Bordeaux, França)
2012/04 Modulation of hippocampal glutamatergic synapses by the appetite-stimulating hormone Ghrelin SINAL 2012
SINAL (Braga, Portugal)
2011/05 Mechanisms of synaptic traffic of glutamate receptors Seminar at Biogem
Biogem (Ariano, Itália)
2007/07 AMPA-type glutamate receptors: regulation by BDNF, interacting proteins and alternative splicing Life Sciences 2007
Biochemical Society & British Pharmacological Society and The Physiological Society (Glasgow, Reino Unido)
2006/11 Phosphorylation and traffic of glutamate receptors of the AMPA type Seminar Series Brain Research Centre, University of British Columbia
Ann Marie Craig (Vancouver, Canadá)
2005/03 AMPA receptor phosphorylation and trafficking 25th European Winter Conference on Brain Research
European Winter Conference on Brain Research (Les Arcs, França)
2004/12 Role of glutamate receptor trafficking in synaptic regulation XIV National Biochemistry Meeting
Portuguese Biochemistry Society (Vilamoura, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019 - Atual Cerebellar dysfunction in neuropsychiatric disorders: insights from human mutations in Stargazin
Orientador de Nuno Beltrão Marques
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - Atual Role of prefrontal cortex circuit defects in cognitive alterations in Intellectual Disability and Schizophrenia mouse models
Orientador de Orsolya Antal
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - Atual Stargazin as a regulator of neuronal excitability
Orientador de Marina Rodrigues
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - Atual Synaptic regulation by chronic stress-induced miRNA
Orientador de Beatriz Rodrigues
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - Atual Unraveling the role of ghrelin in cognition: effects on spine dynamics and structural plasticity
Orientador de Débora Serrenho
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2014 - 2021/10 Characterization of the Novel Rho-GTPase Activating Protein BPGAP1 in the Central Nervous System
Orientador de Jeannette Schmidt
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/09 - 2020/12 HIPPOCAMPAL DYSFUNCTION IN ANIMAL MODELS OF NEURODEVELOPMENTAL DISORDERS
Coorientador de Renato Rodrigo Macedo
Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09 - 2020/11 Exploring the pathogenic mechanisms elicited by antibody-mediated loss of Caspr2 in autoimmune synaptic encephalitis
Coorientador de Ana Maria da Graça Fernandes Vasconcelos
Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2020/07 Peptides that signal hunger - a new role in memory and social behaviors
Coorientador de Mário Jorge da Silva Carvalho
Bioengenharia - Programa MIT-Portugal (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2018 2B or not 2B that is the question about the synaptic proteasome in glutamatergic synapses
Orientador de Rodolfo das Neves Águas
Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2018 Stargazin mutations and psychiatric disorders: the case of intellectual disability
Orientador de Nuno Miguel Beltrão Marques
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2018 Super resolution imaging reveals differential organization and regulation of NMDA receptor subtypes
Orientador de Blanka Kellermayer
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2018 Role of Caspr1 and Caspr2 in the regulation of glutamatergic transmission and synaptic plasticity - implication for disease pathogenesis
Orientador de Dominique Moreira Fernandes
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2018 Unveiling the role of miRNAs in synaptic plasticity
Orientador de Mariline Mendes Silva
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/09/05 - 2017/12/22 Dissecting the role of GPRASP2 in autism spectrum disorder and intellectual disability
Coorientador de Mohamed Edfawy Soliman Hussien
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - 2017 ARHGAP8 co-regulates excitatory and inhibitory synapse function
Orientador de Inês Baião Santos
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017 Behavioral and Biochemical Characterization of Stargazin knock-in mice expressing an Intellectual disability-linked mutation.
Orientador de Tiago Batista Abrantes Rondão
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2017 The role of stargazin in the pathogenesis of psychiatric disorders
Orientador de Gladys Tarcila Lima Caldeira
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016 - 2016 The interactome of stargazin: relevance in neuropsychiatric disorders
Orientador de Marina Manuela Ventura Rodrigues
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 miRNAs in the regulation of synaptic function
Orientador de Beatriz Rodrigues
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Ghrelin receptor activation regulates hippocampal spine dynamics
Coorientador de Débora Serrenho
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Scale for mapping the brain: the role of stargazin in regulating dendritic spine morphology
Coorientador de Joana Freitas
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2015 Regulation of ataxin-3 by phosphorylation: relevance for Machado-Joseph disease
Orientador de Carlos Adriano Albuquerque Andrade de Matos
Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014 Intelligent design of color-tuned ChR2 variants for optogenetics applications
Coorientador de Bruno Filipe Pereira da Cruz
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014 Molecular mechanisms of the synaptic and cognitive effects of ghrelin
Coorientador de Mário Jorge da Silva Carvalho
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2014 Molecular Mechanisms Coupling Calcium-permeable Ampa Receptors to Excitotoxic Signalling Pathways
Coorientador de Marta Isabel Dias da Mota Vieira
Ciências e Tecnologias da Saúde (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2014 In vitro Ischemia-induced changes in the Transcriptome of Hippocampal Neurons: Neuroprotective Pathways in Brain Ischemia
Coorientador de Joana Filipa Coelho Fernandes
Ciências e Tecnologias da Saúde (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2013 Effects of ghrelin on hippocampal glutamate receptors and neuronal morphology
Orientador de J Fiona van Leeuwen
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2013 A Link Between Metabolic Signaling and Cognition: The Hippocampal Function of Ghrelin
Orientador de Luís Filipe da Silva Ribeiro
Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2012 Role of ataxin3 aggregation and phosphorylation in the pathogenesis of Machado-Joseph disease
Orientador de Marilisa Vigorita
Biology (Mestrado)
Università degli Studi del Sannio, Itália
2008 - 2012 Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type: Implications in Synaptic Plasticity
Orientador de Joana Isabel Simões Ferreira
Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2012 Synapse Development in a Mouse Model fo ran Autism-Spectrum Disorder
Coorientador de João Manuel Assunção Noutel dos Santos
Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2012 The Role of Transmembrane Receptor Regulatory Proteins (TARPs) in Synapse Remodeling and Homeostatic Plasticity.
Orientador de Susana Ribeiro dos Louros
Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2012 Regulation of Synapse Composition by Protein Acrylation: the Role of Acetylated Cortactin
Orientador de Tatiana Andreia Forjaz Amaral Catarino
Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2011 Post-transcriptional mechanisms of regulation of AMPA receptors: Regulation of GluA1 expression by the Contactin associated protein 1
Orientador de Dominique Moreira Fernandes
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2011 The GluN2B subunit of NMDA receptors and its role in glutamatergic synapses: Towards the characterization of the proteome of postsynaptic densities from wild-type and GluN2B-null cultured neurons
Orientador de Pedro Rio
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2011 The role of Caspr1 in AMPA receptor traffic
Orientador de Olga Iuliano
Biology (Mestrado)
Università degli Studi del Sannio, Itália
2005 - 2011 VGLUT1 and VGLUT2 cleavage under excitotoxic conditions and in cerebral ischemia
Coorientador de Andrea Catarina Amaro de Campos Lobo
Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2009 Post-Translational Modifications of Ataxin-3, the protein involved in Machado-Joseph disease: Evidences for Phosphorylation and Sumoylation
Orientador de Carlos Adriano Matos
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2009 Proteomic Analysis of the Interactome of Glutamate Receptors of the Ampa Type: Contactin Associated Protein 1 as a Regulator of Ampa Receptors
Orientador de Sandra Manuela Domingues dos Santos
Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007 - 2007 Excitotoxic mechanisms associated to Ca2+-permeable AMPA receptors: the role of the JNK signaling pathway
Coorientador de Marta Mota Vieira
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2021/12/01 - 2021/12/03 17th Meeting of the Portuguese Neuroscience Society (SPN) (2021/12/01)
Conferência (Membro da Comissão Organizadora)
2001 - 2020 Organization of 28 seminars by invited national and international scientists at the CNC-Center for Neuroscience and Cell Biology Seminar Series (2001 - 2020)
Seminário (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/01/25 - 2018/01/25 Integrating Glial and Neuronal Function (2018/01/25 - 2018/01/25)
Oficina (workshop) (Coorganizador)
2017/10/23 - 2017/10/26 ‘Synaptic defects in brain diseases’ symposium at the FEBS3+ - 1st joint meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies (2017/10/23 - 2017/10/26)
Simpósio (Coorganizador)
2016/06/01 - 2016/06/04 7th ISN meeting ‘Synaptic function and dysfunction in brain diseases’ (2016/06/01 - 2016/06/04)
Conferência (Coorganizador)
2013/05/30 - 2013/06/01 13th Meeting of the Portuguese Neuroscience Society (SPN) (2013/05/30 - 2013/06/01)
Conferência (Membro da Comissão Organizadora)
2011/04/28 - 2011/04/30 5th SINAL meeting (2011/04/28 - 2011/04/30)
Conferência (Membro da Comissão Organizadora)
2001/09/13 - 2001/09/14 7th Meeting of the Portuguese Neuroscience Society (2001/09/13 - 2001/09/14)
Conferência (Membro da Comissão Organizadora)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - Atual Frontiers in Molecular Neuroscience (Review Editor) (1662-5099) Frontiers Media SA
2014 - Atual Frontiers in Pharmacology - Neuropharmacology (Review Editor) (1663-9812) Frontiers Media SA

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2010 - Atual Grant Reviewer for the following organizations (part I): •Biotechnology and Biological Sciences Research Council (BBSRC, UK) •ERA-NET Neuron (2017, 2018; EU) •Fondation Fondamental (France) •Fundação para a Ciência e a Tecnologia (FCT, Portugal) •iMed.ULisboa Young Investigator Projects for Collaborative Cross-disciplinary Studies (Portugal) •INSERM/CNRS ATIP-Avenir program (France) •Israely Ministry of Health (Israel) •Medical Research Council (MRC, UK) •Netherlands Organization for Scientific Research (NWO, The Netherlands)
Avaliador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010 - Atual Grant reviewer for the following organisations (part II): •Neurological Foundation of New Zealand (New Zealang) •Research Foundation Flanders (FWO, Belgium) •Wellcome Trust (UK)
Avaliador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - Atual Adhoc reviewer for the following journals (part I): BMC Genomics, BMC Neuroscience, Brain Research, British J Pharmacolog, Cell Biology International, Cell Death and Disease, Cell Reports, Cellular and Molecular Neurobiology, Cellular and Molecular Life Sciences, Disease Models & Mechanisms, eLIFE, EMBO J, European J Neuroscience, European J Pharmacology, Experimental Eye Research
Avaliador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - Atual Adhoc reviewer for the following journals (part II): •Frontiers in Cellular Neuroscience •Frontiers in Molecular Neuroscience •Frontiers in Neuroscience •Frontiers in Neuroscience - Neuropharmacology •Frontiers in Pharmacology •Frontiers in Psychiatry •Frontiers in Synaptic Neuroscience •Hippocampus •Histochemistry and Cell Biology •Human Molecular Genetics •International J of Developmental Neuroscience •International Journal of Neuroscience •iScience •J Cell Physiology •J Cell Science •J Neurochemistry
Avaliador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - Atual Adhoc reviewer for the following journals (part III): J Neurophysiology, J Neuroscience, J Neuroscience Research, J Physiology, J Proteome Research, J Neuroscience Research, Learning & Memory, Molecular and Cellular Neuroscience, Molecular Biology of the Cell, Naunyn-Schmiedeberg's Archives of Pharmacology, Neural Plasticity, Neurobiology of Stress, Neuropharmacology, Neuropeptides, Neuroreport, Neuroscience, Neurotoxicity Research, Oncotarget, PLoS One, PLoS Genet, PNAS, Schizophrenia Bulletin . Scientific Reports
Avaliador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2020/09/01 - Atual Member of the scientific council of the Instituto Investigação Interdisciplinar (IIIIUC), University of Coimbra
Membro
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016 - Atual Member of the pedagogic council of the Instituto de Investigação Interdisciplinar (IIIUC), University of Coimbra
Membro
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2016 Member of the Scientific Council of Health and Life Sciences for the Portuguese Research Foudation (Fundação para a Ciência e a Tecnologia - FCT)
Membro
Fundação para a Ciência e a Tecnologia, Portugal

Tutoria

Tópico Nome do aluno
2021/10 - Atual Marie-Curie Individual Fellowship - senior postdoctoral position Luís F. Ribeiro
2017 - Atual Post-doctoral fellow Ângela Inácio
2018 - 2022/02 Post-doctoral fellow Dominique Fernandes
2017 - 2021/12 Post-doctoral fellow Gladys Caldeira
2018 - 2020/12 Post-doctoral fellow Mariline Silva
2012 - 2017 Post-doctoral fellow Tatiana Catarino
2012 - 2015 Post-doctoral fellow Susana Louros