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Maria João Castro Gouveia. Completed an integrated Master's degree in Chemistry on 11/2011/18 at the University of Porto Faculty of Sciences, PhD in Veterinary Sciences on 12/2019/12 at the University of Porto Institute of Biomedical Sciences Abel Salazar and Degree in Chemistry on 07/30/2009 from the University of Porto Faculty of Sciences. She is a Researcher at the University of Porto Institute of Agricultural and Agro-Food Sciences and Technologies. She published 25 articles in specialized journals. Shee co-supervised 2 work(s) completing a degree course in Biochemistry. She works in the area(s) of Medical and Health Sciences with an emphasis on Health Sciences with an emphasis on Parasitology, namely in the study of processes associated with cancer associated with parasitic infections and the development of new therapies for them. In your Ciência Vitae curriculum, the most frequent terms in the context of scientific production are: S. haematobium; Opisthorchis; Metabolites; schistosomiasis urogenital; bladder cancer ; cytoscopic; Schistosomiasis; Opisthorchiasis; helminth infections-associated cancer; parasitic metabolites; Antioxidants; combination therapy; drug repurposed; Helminth infections; carcinogenesis; DNA adducts; CYP enzymes; antioxidants; drug combination; drug repurposing; Helminth infection,; Malignancy, ; Schistosomiasis,; Opisthorchiasis; Cytochrome P450; Oxysterol; Schistosoma mansoni; antioxidant biomolecules; anthelmintic drug; anticancer drug; newly transformed schistosomula; Anthelmintic; Biomolecules; N-acetylcysteine; Resveratrol; Schistosomula; praziquantel; schistosomiasis; drug delivery; amino acid transport; in vitro and in vivo assays; prodrug design; stability studies; Schistosoma haematobium; bladder; estrogen-DNA adduct; estrogen-like metabolites; squamous cell carcinoma; urogenital schistosomiasis; cytochromes P450; enantiomers; metabolism; praziquantel;; Angola; Bladder; Catechol estrogen quinone; DNA adduct; Squamous cell carcinoma.
Identificação

Identificação pessoal

Nome completo
Maria João Castro Gouveia

Identificadores de autor

Ciência ID
461E-6C7C-BCD1

Websites

Formação
Grau Classificação
2021/07/12 - 2021/07/16
Concluído
Medicinal Plants - Challenges and Opportunities (Outros)
Universidade do Porto Faculdade de Farmácia, Portugal
19
2019/12/12
Concluído
Veterinary Sciences (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Novel therapeutics approaches against Schistosoma haematobium and Opisthorchis viverrini and associated cancer (bladder cancer and cholangiocarcinoma)" (TESE/DISSERTAÇÃO)
Aprovado
2016/06/26
Concluído
Curso de Formaçao em Cultura de Células (Outros)
Universidade do Porto Faculdade de Medicina, Portugal
17
2016/06/01
Concluído
VII Workshop on Cancer Research: biological and molecular basis (Outros)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2011/11/18
Concluído
Chemistry (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Development of new ITK inhibitors to combat HIV/AIDS" (TESE/DISSERTAÇÃO)
2009/07/30
Concluído
Chemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
Produções

Publicações

Artigo em revista
  1. Gouveia, Maria João; Ribeiro, Eduarda; Vale, Nuno. "A Surprising Repurposing of Central Nervous System Drugs against Squamous Cell Carcinoma of the Bladder, UM-UC-5". Pharmaceutics 16 2 (2024): 212. http://dx.doi.org/10.3390/pharmaceutics16020212.
    Publicado • 10.3390/pharmaceutics16020212
  2. da Costa, José Manuel Correia; Gouveia, Maria João; Rinaldi, Gabriel; Brindley, Paul J.; Santos, Júlio; Santos, Lúcio Lara. "Control Strategies for Carcinogenic-Associated Helminthiases: An Integrated Overview". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.626672.
    Publicado • 10.3389/fcimb.2021.626672
  3. Mariana Pereira; Guy Caljon; Maria Gouveia; Louis Maes; Nuno Vale. "Synthesis, Biological Activity and In Silico Pharmacokinetic Prediction of a New 2-Thioxo-Imidazoldidin-4-One of Primaquine". Pharmaceuticals (2021): https://www.mdpi.com/1424-8247/14/3/196.
    10.3390/ph14030196
  4. Lúcio Lara Santos; Júlio Santos; Maria Gouveia; Carina Bernardo; Carlos Lopes; Gabriel Rinaldi; Paul J. Brindley; José M. Correia da Costa. "Urogenital Schistosomiasis—History, Pathogenesis, and Bladder Cancer". Journal of Clinical Medicine (2021): https://www.mdpi.com/2077-0383/10/2/205.
    10.3390/jcm10020205
  5. Vale, Nuno; Duarte, Diana; Silva, Sara; Correia, Ana Salomé; Costa, Bárbara; Gouveia, Maria João; Ferreira, Abigail. "Cell-penetrating peptides in oncologic pharmacotherapy: A review". Pharmacological Research 162 (2020): 105231. http://dx.doi.org/10.1016/j.phrs.2020.105231.
    Publicado • 10.1016/j.phrs.2020.105231
  6. Bernardo, Carina; Santos, Júlio; Costa, Céu; Tavares, Ana; Amaro, Teresina; Marques, Igor; Gouveia, Maria João; et al. "Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen receptor alpha-mediated cell proliferation". Urologic Oncology: Seminars and Original Investigations 38 9 (2020): 738.e23-738.e35. http://dx.doi.org/10.1016/j.urolonc.2020.04.022.
    Publicado • 10.1016/j.urolonc.2020.04.022
  7. Gouveia, Maria João; Brindley, Paul J.; Gärtner, Fátima; Vale, Nuno. "Activity of Combinations of Antioxidants and Anthelmintic Drugs against the Adult Stage of Schistosoma mansoni". Journal of Parasitology Research 2020 (2020): 1-9. http://dx.doi.org/10.1155/2020/8843808.
    Acesso aberto • Publicado • 10.1155/2020/8843808
  8. Vale, Nuno; Gouveia, Maria João; Gärtner, Fátima; Brindley, Paul J. "Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species". Parasitology Research 119 5 (2020): 1443-1453. http://dx.doi.org/10.1007/s00436-020-06640-4.
    Publicado • 10.1007/s00436-020-06640-4
  9. Vale, Nuno; Gouveia MJ; Gärtner, Fátima. "Current and Novel Therapies Against Helminthic Infections: The Potential of Antioxidants Combined with Drugs". Biomolecules 10 3 (2020): 350. http://dx.doi.org/10.3390/biom10030350.
    Publicado • http://dx.doi.org/10.3390/biom10030350
  10. Yang, Vítor; Gouveia, Maria João; Santos, Joana; Koksch, Beate; Amorim, Irina; Gärtner, Fátima; Vale, Nuno. "Breast cancer: insights in disease and influence of drug methotrexate". RSC Medicinal Chemistry 11 6 (2020): 646-664. http://dx.doi.org/10.1039/d0md00051e.
    Publicado • 10.1039/d0md00051e
  11. Gouveia, Maria João; Pakharukova, Maria Y.; Rinaldi, Gabriel; Mordvinov, Viatcheslav A.; Brindley, Paul J.; Gärtner, Fátima; Vale, Nuno. "Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola". Experimental Results 1 (2020): http://dx.doi.org/10.1017/exp.2020.38.
    Publicado • 10.1017/exp.2020.38
  12. Gouveia MJ; Brindley, Paul J.; Rinaldi, Gabriel; Gärtner, Fátima; da Costa, José M. C.; Vale, Nuno. "Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts". Infectious Agents and Cancer 14 1 (2019): http://dx.doi.org/10.1186/s13027-019-0257-2.
    Acesso aberto • Aceite para publicação • 10.1186/s13027-019-0257-2
  13. Gouveia MJ; Nogueira, Verónica; Araújo, Bruno; Gärtner, Fátima; Vale, Nuno. "Inhibition of the Formation In Vitro of Putatively Carcinogenic Metabolites Derived from S. haematobium and O. viverrini by Combination of Drugs with Antioxidants". Molecules 24 21 (2019): 3842. http://dx.doi.org/10.3390/molecules24213842.
    Acesso aberto • Aceite para publicação • 10.3390/molecules24213842
  14. Gouveia MJ; Brindley, Paul J.; Azevedo, Carlos; Gärtner, Fátima; da Costa, José M. C.; Vale, Nuno. "The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity of praziquantel and artesunate against Schistosoma mansoni". Parasites & Vectors 12 1 (2019): http://dx.doi.org/10.1186/s13071-019-3566-9.
    Acesso aberto • Aceite para publicação • 10.1186/s13071-019-3566-9
  15. Gouveia, Maria João; Brindley, Paul J.; Rinaldi, Gabriel; Gärtner, Fátima; da Costa, José Manuel Correia; Vale, Nuno. "Combination Anthelmintic/Antioxidant Activity Against Schistosoma Mansoni". Biomolecules 9 2 (2019): 54. http://dx.doi.org/10.3390/biom9020054.
    10.3390/biom9020054
  16. Vale, Nuno; Ferreira, Abigail; Matos, Joana; Fresco, Paula; Gouveia MJ. "Amino Acids in the Development of Prodrugs". Molecules 23 9 (2018): 2318. http://dx.doi.org/10.3390/molecules23092318.
    Acesso aberto • 10.3390/molecules23092318
  17. Gouveia MJ; Brindley, Paul; Gärtner, Fátima; Costa, José; Vale, Nuno. "Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules". Pharmaceuticals 11 1 (2018): 15. http://dx.doi.org/10.3390/ph11010015.
    Acesso aberto • 10.3390/ph11010015
  18. Gouveia MJ; Pakharukova, Maria Y; Laha, Thewarach; Sripa, Banchob; Maksimova, Galina A; Rinaldi, Gabriel; Brindley, Paul J; et al. "Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model". Carcinogenesis 38 9 (2017): 929-937. http://dx.doi.org/10.1093/carcin/bgx042.
    Publicado • 10.1093/carcin/bgx042
  19. Vale, Nuno; Gouveia MJ; Rinaldi, Gabriel; Brindley, Paul J.; Gärtner, Fátima; Correia da Costa, José M.. "Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance". Antimicrobial Agents and Chemotherapy 61 5 (2017): http://dx.doi.org/10.1128/aac.02582-16.
    Publicado • 10.1128/aac.02582-16
  20. Vale, Nuno; Gouveia MJ; Rinaldi, Gabriel; Santos, Júlio; Santos, Lúcio Lara; Brindley, Paul J; da Costa, José M Correia. "The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer". Tumor Biology 39 3 (2017): 101042831769224. http://dx.doi.org/10.1177/1010428317692247.
    Publicado • 10.1177/1010428317692247
  21. Gouveia MJ; Santos, Júlio; Brindley, Paul J.; Rinaldi, Gabriel; Lopes, Carlos; Santos, Lúcio L.; da Costa, José Manuel Correia; Vale, Nuno. "Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer". Cancer Letters 359 2 (2015): 226-232. http://dx.doi.org/10.1016/j.canlet.2015.01.018.
    Publicado • 10.1016/j.canlet.2015.01.018
  22. Correia da Costa, José M.; Vale, Nuno; Gouveia MJ; Botelho, MC; Sripa, Banchob; Santos, Lúcio L.; Santos, Júlio H.; Rinaldi, Gabriel; Brindley, Paul J.. "Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers". Frontiers in Genetics 5 (2014): http://dx.doi.org/10.3389/fgene.2014.00444.
    Publicado • 10.3389/fgene.2014.00444
  23. Santos, Júlio; Gouveia MJ; Vale, Nuno; Delgado, Maria de Lurdes; Gonçalves, Ana; da Silva, José M. Teixeira.; Oliveira, Cristiano; et al. "Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected with Schistosoma haematobium". PLoS ONE 9 5 (2014): e96774. http://dx.doi.org/10.1371/journal.pone.0096774.
    10.1371/journal.pone.0096774
  24. Vale, Nuno; Gouveia MJ; Botelho, Mónica; Sripa, Banchob; Suttiprapa, Sutas; Rinaldi, Gabriel; Gomes, Paula; Brindley, Paul J.; Correia da Costa, José Manuel. "Carcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC–MS/MS survey of soluble fraction parasite extract". Parasitology International 62 6 (2013): 535-542. http://dx.doi.org/10.1016/j.parint.2013.08.001.
    Publicado • 10.1016/j.parint.2013.08.001
  25. Gouveia MJ; Brindley, Paul J.; Santos, Lúcio Lara; Correia da Costa, José Manuel; Gomes, Paula; Vale, Nuno. "Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review". Metabolism 62 9 (2013): 1206-1217. http://dx.doi.org/10.1016/j.metabol.2013.04.003.
    10.1016/j.metabol.2013.04.003
  26. Botelho, Mónica C.; Vale, Nuno; Gouveia MJ; Rinaldi, Gabriel; Santos, Julio; Santos, Lucio L.; Gomes, Paula; Brindley, Paul J.; Correia da Costa, José Manuel. "Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: An oestrogen–DNA adducts mediated pathway?". International Journal for Parasitology 43 1 (2013): 17-26. http://dx.doi.org/10.1016/j.ijpara.2012.10.023.
    10.1016/j.ijpara.2012.10.023