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Sara Silva received a BSc in Biomedical Science at the University of Algarve. She then took her Master's Degree in Cellular and Molecular Biology from the Faculty of Science of the University of Porto. Her master's thesis was developed at Department of Chemistry and Biochemistry Of Faculty of Science with collaboration at Instituto Ricardo Jorge in Porto, where she aimed to develop new antimicrobial peptides against mycobacterium tuberculosis. She had the opportunity to manually synthesize and characterize therapeutical peptides and work with human pathogen in a level 3 (P3) biosafety environment. In 2018, enrolled in the Doctoral Programme of Pharmaceutical Science of the Faculty of Pharmacy of the University of Porto. She was granted through i3DU doctoral programme, a FCT doctoral grant to develop a dual-delivery system composed of cell-penetrating peptides and nanoparticles for biomedical applications. With an interdisciplinary background, Sara's expertise includes peptide synthesis, preparation, characterization, and functionalization of nanoparticles, drug delivery, cell culture, and biomaterials. At the moment, she is a Pos-Doc Fellow in the Molecular Biomaterials Group at i3S
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Identificação

Identificação pessoal

Nome completo
Sara Cristina Pinto Silva
Data de nascimento
1994/07/21
Género
Feminino

Nomes de citação

  • Silva, Sara

Identificadores de autor

Ciência ID
4316-E24A-4B38
ORCID iD
0000-0001-8164-2504

Endereços de correio eletrónico

  • scsilva@i3s.up.pt (Profissional)
  • saracpsilva21@gmail.com (Pessoal)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B2)
Português (Idioma materno)
Formação
Grau Classificação
2018 - 2022/12/21
Concluído
 Ciências Farmacêuticas (Doutoramento)
Especialização em Farmacologia e Farmacoterapia
Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2017
Concluído
 Biologia Celular e Molecular (Mestrado integrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Development of new cationic antimicrobial peptides against Mycobacterium Tuberculosis" (TESE/DISSERTAÇÃO)
 18
2012 - 2015
Concluído
 Ciências Biomédicas (Licenciatura)
Universidade do Algarve, Portugal
"Magnetic Resonance Imaging biomarkers in Hereditary Hemochromatosis" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/03/01 - Atual Pós-doutorado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Projetos

Bolsa

Designação Financiadores
2023/03/01 - 2025/03/01 Recreation of the blood-brain barrier microvasculature network by integrating innovative molecular engineering approaches and 3D printing technologies
2022.01690.PTDC
Bolseiro de Pós-Doutoramento
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Sara Silva; Kaido Kurrikoff; Ülo Langel; António J. Almeida; Nuno Vale. "A Second Life for MAP, a Model Amphipathic Peptide". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23158322.
    10.3390/ijms23158322
  2. Sara Silva; Joana Marto; Lídia M. Gonçalves; Diana Duarte; O. Salomé G. P. Soares; Francisco Vasques-Nóvoa; António J. Almeida; Nuno Vale. "New Peptide Functionalized Nanostructured Lipid Carriers with CNS Drugs and Evaluation Anti-proliferative Activity". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23137109.
    10.3390/ijms23137109
  3. Sara Silva; Joana Marto; Lídia M. Gonçalves; Henrique S. Fernandes; Sérgio F. Sousa; António J. Almeida; Nuno Vale. "Development of Neuropeptide Y and Cell-Penetrating Peptide MAP Adsorbed onto Lipid Nanoparticle Surface". Molecules (2022): https://doi.org/10.3390/molecules27092734.
    10.3390/molecules27092734
  4. Sara Silva; António J. Almeida; Nuno Vale. "Importance of Nanoparticles for the Delivery of Antiparkinsonian Drugs". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13040508.
    10.3390/pharmaceutics13040508
  5. Silva, Sara; Almeida, António J.; Vale, Nuno. "Acetylcholinesterase inhibitors and nanoparticles on Alzheimer’s disease: a review". Journal of Nanoparticle Research 23 1 (2021): http://dx.doi.org/10.1007/s11051-020-05118-9.
    10.1007/s11051-020-05118-9
  6. Nuno Vale; Sara Silva; Diana Duarte; Diana M. A. Crista; Luís Pinto da Silva; Joaquim C. G. Esteves da Silva. "Normal breast epithelial MCF-10A cells to evaluate the safety of carbon dots". RSC Medicinal Chemistry (2021): https://doi.org/10.1039/D0MD00317D.
    10.1039/D0MD00317D
  7. Sara Silva; Cláudia Alves; Diana Duarte; Ana Costa; Bruno Sarmento; António J. Almeida; Paula Gomes; Nuno Vale. "Model Amphipathic Peptide Coupled with Tacrine to Improve Its Antiproliferative Activity". International Journal of Molecular Sciences 22 1 (2020): 242-242. https://doi.org/10.3390/ijms22010242.
    10.3390/ijms22010242
  8. Sara Silva; Joana Marto; Lídia Gonçalves; Anto´nio J. Almeida; Nuno Vale. "Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles". Nanomaterials (2020): https://doi.org/10.3390/nano10102089.
    10.3390/nano10102089
  9. Vale, Nuno; Duarte, Diana; Silva, Sara; Correia, Ana Salomé; Costa, Bárbara; Gouveia, Maria João; Ferreira, Abigail. "Cell-penetrating peptides in oncologic pharmacotherapy: A review". Pharmacological Research (2020): 105231. http://dx.doi.org/10.1016/j.phrs.2020.105231.
    Publicado • 10.1016/j.phrs.2020.105231
  10. Vale, Nuno; Alves, Cláudia; Sharma, Vaishali; Lázaro, Diana F.; Silva, Sara; Gomes, Paula; Outeiro, Tiago Fleming. "A new MAP-Rasagiline conjugate reduces a-synuclein inclusion formation in a cell model". Pharmacological Reports (2020): http://dx.doi.org/10.1007/s43440-019-00032-x.
    10.1007/s43440-019-00032-x
  11. Silva, Sara; Santos-Silva, Anabela; Manuel Correia da Costa, José; Vale, Nuno. "Potent cationic antimicrobial peptides against Mycobacterium tuberculosis in vitro". Journal of Global Antimicrobial Resistance (2019): http://dx.doi.org/10.1016/j.jgar.2019.04.018.
    10.1016/j.jgar.2019.04.018
  12. Sara Silva; António J. Almeida; Nuno Vale. "Combination of Cell-Penetrating Peptides with Nanoparticles for Therapeutic Application: A Review". Biomolecules (2019): http://www.mdpi.com/2218-273X/9/1/22.
    10.3390/biom9010022
  13. Silva, S.; Vale, N.. "Cationic antimicrobial peptides for tuberculosis: A mini-review". Current Protein and Peptide Science 20 9 (2019): 885-892. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072746247&partnerID=MN8TOARS.
    10.2174/1389203720666190626160057
  14. França, Manuela; Silva, Sara. "Tissue iron quantification in chronic liver diseases using MRI shows a relationship between iron accumulation in liver, spleen, and bone marrow". Clinical radiology (2018): https://doi.org/10.1016/j.crad.2017.07.022.
    10.1016/j.crad.2017.07.022
  15. França, Manuela; Silva, Sara. "Optimizing the management of hereditary haemochromatosis: the value of MRI R2* quantification to predict and monitor body iron stores". British journal of haematology (2017): https://doi.org/10.1111/bjh.14982.
    10.1111/bjh.14982
  16. Nuno Vale; Alexandra Correia; Sara Silva; Patrícia Figueiredo; Ermei Mäkilä; Jarno Salonen; Jouni Hirvonen; et al. "Preparation and biological evaluation of ethionamide-mesoporous silicon nanoparticles against Mycobacterium tuberculosis". Bioorganic & Medicinal Chemistry Letters (2016): http://dx.doi.org/10.1016/j.bmcl.2016.12.060.
    10.1016/j.bmcl.2016.12.060
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2018/02/07 Development of new antimicrobial peptides against Mycobacterium Tuberculosis XLVIII Reunião Anual da SOCIEDADE PORTUGUESA DE FARMACOLOGIA
(Lisboa, Portugal)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/07/01 - 2020/10/31 Reaproveitamento de Fármacos para Oncologia e COVID-19 - Módulo 2 Duplos sistemas de libertação de fármacos em células tumorais Reaproveitamento de Fármacos para Oncologia e COVID-19 (Outros) Universidade do Porto Faculdade de Medicina, Portugal