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Maria Mota completed her BSc in Biology and an MSc in Immunology from the University of Porto, her PhD in Parasitology at the University College London/NIMR and a post-doc at NYU. Since 2002 Maria Mota has been a group leader, first at Instituto Gulbenkian de Ciência (IGC) and then at Instituto de Medicina Molecular (iMM). As an independent researcher Maria Mota focused on studying both the liver and the blood stages of infection by the Plasmodium parasite. Her team¿s overall goal has been towards the elucidation of the most fundamental and conceptually innovative questions of Host-Plasmodium interactions leading to groundbreaking discoveries. By showing that Plasmodium activates a type I IFN response in the liver (Nature Medicine, 2014) the Mota Lab has challenged the widespread assumption that Plasmodium can infect and replicate inside hepatocytes undetected. Her work also demonstrates that active interactions with the host cellular machinery are required during Plasmodium liver stage to prevent clearance. Examples are two proteins that operate on ensuring parasite survival by blocking infected cells autophagy (Nature Microbiology, 2018) and through interaction with host cell actin to elute host cytosolic defenses (iScience, 2022). With recent work the team further enriched our understanding on liver stage infection by providing a comprehensive single-cell gene profiling of hepatocytes and parasites in infected livers over time (Nature, 2022). Furthermore, Maria Mota’s team revealed that nutrient availability and dietary habits strongly impact the establishment and course of a malaria infection by interfering with both host and parasite pathways during different stages of infection (Nature, 2017; Nature Microbiology, 2017; Communications Biology, 2023). Recent data from the Mota Lab reveals the intricate nature of Host-Plasmodium interactions by showing that the liver stage and the blood stage interact towards pathology and disease severity (Immunity, 2023). Moreover, Maria Mota´s team identified a third party determining disease: host microbiota (Nature Communications, 2022). In 2012 Maria Mota received a 5-year Starting/Consoliadtor Grant from the European Research Council (ERC), as well as a 3-year Excellence Grant from FCT. In 2018, Maria Mota was awarded a laCaixa Foundation Health Research Grant. Recently, in 2023, the innovative nature of her research lead to the successful securing of new funding from the ERC with a 5-year Advanced Grant, and from the laCaixa Foundation with another 3-year Health Research Grant. At the institutional level, Maria Mota lead the successful securing of EU-funded projects such as TwinnToInfect (H2020-TWINN-2015) and EXCELLtoINNOV (H2020- Establishing ERA Chairs) to provide IMM with the needed means to achieve international excellence in the immunity and infection area and iMM-CARE (HORIZON-WIDERA-2022- Teaming for Excellence) towards establishing a new centre of excellence for clinical and translational research. Maria Mota has published more than 140 papers cited more than 7000 times (h-index = 49). She has supervised 15 PhD students (concluded) and more than 18 post-doctoral fellows (current and concluded). Her scientific merit was recognized internationally and won several prizes and awards such as: EMBO member by the European Molecular Biology Organization in 2016 and in 2018 the Sanofi Institut Pasteur Mid-Career Award. Nationally, in 2017 Maria Mota was awarded the Pfizer Prize in Basic Research and in 2013 she was awarded the Pessoa Award, a prestigious national award. Since April 2014 Maria Mota is the Executive Director of iMM. Under her leadership, iMM has significantly enriched its critical mass and became a dynamic structure based on a vibrant faculty with an outstanding research portfolio. iMM is now merging with IGC. A new Foundation has been created – Gulbenkian Institute for Molecular Medicine (GIMM) and Maria Mota was recently elected the President and CEO of GIMM.
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Identificação

Identificação pessoal

Nome completo
Maria Manuel Dias da Mota

Nomes de citação

  • Mota, Maria M.
  • Mota, MM
  • Maria Manuel Mota

Identificadores de autor

Ciência ID
4217-0969-297E
ORCID iD
0000-0002-2858-1041

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde - Parasitologia
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências Naturais - Ciências Biológicas - Biologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português (Idioma materno)
Formação
Grau Classificação
2019/07/17
Concluído
 Biomedical Sciences (Título de Agregado)
Especialização em Microbiology and Parasitology
Universidade de Lisboa Faculdade de Medicina, Portugal
 Aprovado
1999
Concluído
 Molecular Parasitology (Doutoramento)
National Institute for Medical Research, University College London, Reino Unido
"Sequestration and the infected-erythrocyte surface in Plasmodium chabaudi malaria infection" (TESE/DISSERTAÇÃO)
 -
1995
Concluído
 Imunologia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Studies on Plasma Produced during resolution of parasitemia in rodent malaria" (TESE/DISSERTAÇÃO)
 -
1992
Concluído
 Licenciatura em Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 -
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2005/04/01 - Atual Investigador Coordenador (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2002/01/01 - 2004/12/31 Investigador principal (carreira) (Investigação) Instituto Gulbenkian de Ciência, Portugal
1999/11/01 - 2001/01/31 Pós-doutorado (Investigação) NewYork-Presbyterian/Columbia University Medical Center, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2014 - Atual Professor Associado Convidado (Docente Universitário) Universidade de Lisboa, Portugal
2011/06/01 - 2019/12/31 Professor Visitante (Docente Universitário) Harvard University T H Chan School of Public Health, Estados Unidos
Harvard University T H Chan School of Public Health, Estados Unidos
2013 - 2014 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2014/04/01 - Atual Executive Director Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
Projetos

Bolsa

Designação Financiadores
2023/05/01 - 2029/04/30 Excellence in clinical and translational research in Portugal
101060102
Investigador responsável
Instituto de Medicina Molecular, Portugal
Em curso
2023/06/01 - 2028/05/31 Plasmodium liver stage schizogony: high replication and genetic diversity
AdG - 101097801
Investigador responsável
Instituto de Medicina Molecular, Portugal
Em curso
2023/12/01 - 2026/11/30 Genetic variability in Plasmodium Liver Stage Schizogony
HR23-00499
Investigador responsável
Instituto de Medicina Molecular, Portugal
Em curso
2018/12/01 - 2021/11/30 Plasmodium Exploitation of Liver-specific Methionine Metabolism
HR17-00264
Investigador responsável
Instituto de Medicina Molecular, Portugal
 laCaixa Foundation
Concluído
2015/07/01 - 2021/06/30 Leverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.
667824
10.3030/667824
Investigador responsável
Instituto de Medicina Molecular, Portugal
 European Commission
Concluído
2018/06/01 - 2021/05/31 Hepatic metabolism driving Plasmodium replication
LISBOA-01-0145-FEDER-030751
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/04/01 - 2019/09/30 Evasion of host-mediated autophagy: mechanisms of Plasmodium survival in the liver-stage infection
FCT/PTDC/BIM-MEC/1342/2014
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/01/01 - 2018/12/31 Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation
692022
10.3030/692022
Investigador responsável
Instituto de Medicina Molecular, Portugal
 European Commission
Concluído
2016/10/01 - 2018/09/30 Plasmodium autophagy evasion in the liver-stage: mechanisms and novel therapeutic opportunities
MRG_20052016
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Institut Mérieux
Concluído
2016/11/01 - 2018/05/30 Drug Repurposing for Malaria Chemoprotection
PoC 713691
Investigador responsável
Instituto de Medicina Molecular, Portugal
 European Research Council
Concluído
2012/12 - 2017/11 Nutrient sensing by parasites
311502
Investigador responsável
Instituto de Medicina Molecular, Portugal
 European Research Council
Concluído
2013/04 - 2016/04 Animal models of human disease: refinement of strategies and implementation of new technologies
Provided by PTCRIS: 125967
 Fundação para a Ciência e a Tecnologia, I.P.
2013/01 - 2015/12 Host-Plasmodium interactions: a tale of sensing and being sensed
Provided by PTCRIS: 124777
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2010 - 2015 Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR)
EVIMalaR
Outra
European Union
Concluído
2010/04 - 2013/09 New drugs for treating and eradicating malaria
Provided by PTCRIS: 110357
 Fundação para a Ciência e a Tecnologia, I.P.
2010/02 - 2013/01 Respiratory tract infections & malaria: a new case of mutual interactions?
Provided by PTCRIS: 108578
 Fundação para a Ciência e a Tecnologia, I.P.
2008/05 - 2011/04 The role of host cell kinases in Plasmodium development inside hepatocytes during the liver stage of malaria infections
Provided by PTCRIS: 72211
 Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2010 Functional genomics in malaria - which are the host cell molecules and pathways required for Plasmodium development inside hepatocytes?
55005523
Investigador responsável
Howard Hughes Medical Institute
Concluído
2004 - 2009 The role of host cell factors in full development of the malaria parasite inside hepatocytes
EURYI – 2004
Investigador responsável
European Science Foundation
Concluído
2004 - 2009 The role of host cell factors in full development of the malaria parasite inside hepatocytes
EURYI 2004
 European Science Foundation
2007/01 - 2008/08 The role of Hemeoxygenase-1 and its products in the course and pathology of malaria infection.
Provided by PTCRIS: 82583
 Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2007 Differential expression of malaria parasite invasion-associated proteins in sporozoite. Novel vaccination strategy (MALINV)
MALINV
Outra
European Union
Concluído
2005/09 - 2006/12 The role of Hemeoxygenase-1 and its products in the course and pathology of malaria infection.
Provided by PTCRIS: 57946
 Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2006/12 The role of Plasmodium molecules that migrate to the host cell nucleus during the hepatocyte infection
Provided by PTCRIS: 61799
 Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2006/12 Functional genomics in malaria - an unbias RNAi screen to determine the required host cell molecules and pathways for Plasmodium sporozoite fully development inside hepatocytes
Provided by PTCRIS: 60930
 Fundação para a Ciência e a Tecnologia, I.P.
2003/04 - 2006/03 Mechanism of action of Hepatocyte Growth Factor (HGF) released by sporozoite-wounded hepatocytes during malaria infection
Provided by PTCRIS: 44517
 Fundação para a Ciência e a Tecnologia, I.P.
2002/02 - 2005/02 Host-Parasite Interactions during the Hepatic Stages of Malaria Infections
Provided by PTCRIS: 38563
 Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Chantal T. Harris; Xinran Tong; Riward Campelo; Inês M. Marreiros; Leen N. Vanheer; Navid Nahiyaan; Vanessa A. Zuzarte-Luís; et al. "Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation". Nature Microbiology (2023): https://doi.org/10.1038/s41564-023-01396-w.
    10.1038/s41564-023-01396-w
  2. Aparajita Lahree; João Mello-Vieira; Maria M. Mota. "The nutrient games – Plasmodium metabolism during hepatic development". Trends in Parasitology (2023): https://doi.org/10.1016/j.pt.2023.03.013.
    10.1016/j.pt.2023.03.013
  3. Chora, Ângelo Ferreira; Marques, Sofia; Gonçalves, Joana Lisboa; Lima, Priscila; Gomes da Costa, Daniel; Fernandez-Ruiz, Daniel; Marreiros, Maria Inês; et al. "Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via ¿d T cells and IL-17-promoted stress erythropoiesis". Immunity 56 3 (2023): 592-605.e8. http://dx.doi.org/10.1016/j.immuni.2023.01.031.
    10.1016/j.immuni.2023.01.031
  4. Inês M. Marreiros; Sofia Marques; Ana Parreira; Vincent Mastrodomenico; Bryan C. Mounce; Chantal T. Harris; Björn F. Kafsack; et al. "A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency". Communications Biology (2023): https://doi.org/10.1038/s42003-023-04566-y.
    10.1038/s42003-023-04566-y
  5. Amichay Afriat; Vanessa Zuzarte-Luís; Keren Bahar Halpern; Lisa Buchauer; Sofia Marques; Ângelo Ferreira Chora; Aparajita Lahree; et al. "A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage". Nature (2022): https://doi.org/10.1038/s41586-022-05406-5.
    10.1038/s41586-022-05406-5
  6. Chora, Ângelo Ferreira; Mota, Maria M.; Prudêncio, Miguel. "The reciprocal influence of the liver and blood stages of the malaria parasite's life cycle". International Journal for Parasitology 52 11 (2022): 711-715. http://dx.doi.org/10.1016/j.ijpara.2022.02.002.
    Publicado • 10.1016/j.ijpara.2022.02.002
  7. Mukherjee, Debanjan; Chora, Ângelo Ferreira; Lone, Jean-Christophe; Ramiro, Ricardo S.; Blankenhaus, Birte; Serre, Karine; Ramirez, Mário; et al. "Host lung microbiota promotes malaria-associated acute respiratory distress syndrome". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-31301-8.
    Publicado • 10.1038/s41467-022-31301-8
  8. Viriato M’Bana; Aparajita Lahree; Sofia Marques; Ksenija Slavic; Maria M. Mota. "Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination". iScience (2022): https://doi.org/10.1016/j.isci.2022.104281.
    10.1016/j.isci.2022.104281
  9. Lahree, Aparajita; Baptista, Sara de Jesus Santos; Marques, Sofia; Perschin, Veronika; Zuzarte-Luís, Vanessa; Goel, Manisha; Choudhary, Hadi Hasan; et al. "Active APPL1 sequestration by Plasmodium favors liver-stage development". Cell Reports 39 9 (2022): 110886. http://dx.doi.org/10.1016/j.celrep.2022.110886.
    10.1016/j.celrep.2022.110886
  10. Canto e Castro, Luísa; Gomes, Andreia; Serrano, Marta; Pereira, Ana Helena Guia; Ribeiro, Rita; Napoleão, Patrícia; Domingues, Inês; et al. "Longitudinal SARS-CoV-2 seroprevalence in Portugal and antibody maintenance 12 months after infection". European Journal of Immunology 52 1 (2021): 149-160. http://dx.doi.org/10.1002/eji.202149619.
    10.1002/eji.202149619
  11. Canto e Castro, Luísa; Pereira, Ana Helena Guia; Ribeiro, Rita; Alves, Catarina; Veloso, Luís; Vicente, Vera; Alves, Dalila; et al. "Prevalence of SARS-CoV-2 Antibodies after First 6 Months of COVID-19 Pandemic, Portugal". Emerging Infectious Diseases 27 11 (2021): 2878-2881. http://dx.doi.org/10.3201/eid2711.210636.
    10.3201/eid2711.210636
  12. João Mello-Vieira; Francisco J. Enguita; Tania F. de Koning-Ward; Vanessa Zuzarte-Luís; Maria M. Mota. "Plasmodium translocon component EXP2 facilitates hepatocyte invasion". Nature Communications (2020): https://doi.org/10.1038/s41467-020-19492-4.
    10.1038/s41467-020-19492-4
  13. Sonali Setua; Francisco J. Enguita; Ângelo Ferreira Chora; Harish Ranga-prasad; Aparajita Lahree; Sofia Marques; Varadharajan Sundaramurthy; Maria M. Mota. "Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells". Communications Biology (2020): https://doi.org/10.1038/s42003-020-01422-1.
    10.1038/s42003-020-01422-1
  14. Balasubramanian, L.; Zuzarte-Luís, V.; Syed, T.; Mullick, D.; Deb, S.; Ranga-Prasad, H.; Meissner, J.; et al. "Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development". Frontiers in Cellular and Infection Microbiology 9 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078863463&partnerID=MN8TOARS.
    10.3389/fcimb.2019.00451
  15. Mukherjee, D.; Chora, Â.F.; Mota, M.M.. "Microbiota, a Third Player in the Host–Plasmodium Affair". Trends in Parasitology 36 1 (2020): 11-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075853824&partnerID=MN8TOARS.
    10.1016/j.pt.2019.11.001
  16. Vera, Iset Medina; Grilo Ruivo, Margarida T.; Lemos Rocha, Leonardo F.; Marques, Sofia; Bhatia, Sangeeta N.; Mota, Maria M.; Mancio-Silva, Liliana. "Targeting liver stage malaria with metformin". JCI Insight 4 24 (2019): http://dx.doi.org/10.1172/jci.insight.127441.
    10.1172/jci.insight.127441
  17. de Menezes, M.N.; Salles, É.M.; Vieira, F.; Amaral, E.P.; Zuzarte-Luís, V.; Cassado, A.; Epiphanio, S.; et al. "IL-1a promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85065972196&partnerID=MN8TOARS.
    10.1038/s41598-019-44125-2
  18. Ribot, J.C.; Neres, R.; Zuzarte-Luís, V.; Gomes, A.Q.; Mancio-Silva, L.; Mensurado, S.; Pinto-Neves, D.; et al. "¿d-T cells promote IFN-¿–dependent Plasmodium pathogenesis upon liver-stage infection". Proceedings of the National Academy of Sciences of the United States of America 116 20 (2019): 9979-9988. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065721677&partnerID=MN8TOARS.
    10.1073/pnas.1814440116
  19. Mota, M.M.; Mello-Vieira, J.. "Parasitism: Anopheles Mosquitoes and Plasmodium Parasites Share Resources". Current Biology 29 13 (2019): R632-R634. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068175719&partnerID=MN8TOARS.
    10.1016/j.cub.2019.05.030
  20. Zuzarte-Luís, V.; Mota, M.M.. "Parasite Sensing of Host Nutrients and Environmental Cues". Cell Host and Microbe 23 6 (2018): 749-758. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047948675&partnerID=MN8TOARS.
    10.1016/j.chom.2018.05.018
  21. Mendes, A.M.; Machado, M.; Gonçalves-Rosa, N.; Reuling, I.J.; Foquet, L.; Marques, C.; Salman, A.M.; et al. "A Plasmodium berghei sporozoite-based vaccination platform against human malaria". npj Vaccines 3 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85052199174&partnerID=MN8TOARS.
    10.1038/s41541-018-0068-2
  22. Armistead, J.S.; Jennison, C.; O'Neill, M.T.; Lopaticki, S.; Liehl, P.; Hanson, K.K.; Annoura, T.; et al. "Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut". Molecular Microbiology 109 4 (2018): 458-473. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053478759&partnerID=MN8TOARS.
    10.1111/mmi.13993
  23. Zuzarte-Luis, V.; Mota, M.M.. "Fighting for Resources: Who Started the Battle? Who Is Winning It?". Cell Metabolism 27 4 (2018): 708-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044530685&partnerID=MN8TOARS.
    10.1016/j.cmet.2018.03.007
  24. Vanessa Zuzarte-Luís; João Mello-Vieira; Inês M. Marreiros; Peter Liehl; Ângelo F. Chora; Céline K. Carret; Tânia Carvalho; Maria M. Mota. "Dietary alterations modulate susceptibility to Plasmodium infection". Nature Microbiology 2 12 (2017): 1600-1607. https://doi.org/10.1038/s41564-017-0025-2.
    10.1038/s41564-017-0025-2
  25. Eliana Real; Lénia Rodrigues; Ghislain G. Cabal; Francisco J. Enguita; Liliana Mancio-Silva; João Mello-Vieira; Wandy Beatty; et al. "Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes". Nature Microbiology (2017): https://doi.org/10.1038/s41564-017-0054-x.
    10.1038/s41564-017-0054-x
  26. Sá E Cunha, C.; Nyboer, B.; Heiss, K.; Sanches-Vaz, M.; Fontinha, D.; Wiedtke, E.; Grimm, D.; et al. "Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development". Proceedings of the National Academy of Sciences of the United States of America 114 7 (2017): E1138-E1147. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012991824&partnerID=MN8TOARS.
    10.1073/pnas.1606419114
  27. Mancio-Silva, L.; Slavic, K.; Grilo Ruivo, M.T.; Grosso, A.R.; Modrzynska, K.K.; Vera, I.M.; Sales-Dias, J.; et al. "Nutrient sensing modulates malaria parasite virulence". Nature 547 7662 (2017): 213-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-85024370548&partnerID=MN8TOARS.
    10.1038/nature23009
  28. Tanowitz, H.B.; Scherer, P.E.; Mota, M.M.; Figueiredo, L.M.. "Adipose Tissue: A Safe Haven for Parasites?". Trends in Parasitology 33 4 (2017): 276-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008413087&partnerID=MN8TOARS.
    10.1016/j.pt.2016.11.008
  29. Ng, S.; March, S.; Galstian, A.; Gural, N.; Stevens, K.R.; Mota, M.M.; Bhatia, S.N.. "Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85016564235&partnerID=MN8TOARS.
    10.1038/srep45424
  30. Slavic K; Krishna S; Lahree A; Bouyer G; Hanson KK; Vera I; Pittman JK; Staines HM; Mota MM. "A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium.". (2016): http://europepmc.org/abstract/med/26786069.
    10.1038/ncomms10403
  31. Ruivo, M.T.G.; Vera, I.M.; Sales-Dias, J.; Meireles, P.; Gural, N.; Bhatia, S.N.; Mota, M.M.; Mancio-Silva, L.. "Host AMPK Is a Modulator of Plasmodium Liver Infection". Cell Reports 16 10 (2016): 2539-2545. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006445957&partnerID=MN8TOARS.
    10.1016/j.celrep.2016.08.001
  32. Thieleke-Matos, C.; Lopes da Silva, M.; Cabrita-Santos, L.; Portal, M.D.; Rodrigues, I.P.; Zuzarte-Luis, V.; Ramalho, J.S.; et al. "Host cell autophagy contributes to Plasmodium liver development". Cellular Microbiology 18 3 (2016): 437-450. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958112950&partnerID=MN8TOARS.
    10.1111/cmi.12524
  33. March S; Ramanan V; Trehan K; Ng S; Galstian A; Gural N; Scull MA; et al. "Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.". (2015): http://europepmc.org/abstract/med/26584444.
    10.1038/nprot.2015.128
  34. Liehl P; Zuzarte-Luis V; Mota MM. "Unveiling the pathogen behind the vacuole.". (2015): http://europepmc.org/abstract/med/26189591.
    10.1038/nrmicro3504
  35. Inácio P; Zuzarte-Luís V; Ruivo MT; Falkard B; Nagaraj N; Rooijers K; Mann M; et al. "Parasite-induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection.". (2015): http://europepmc.org/abstract/med/26113366.
    10.15252/embr.201439979
  36. Herman JD; Pepper LR; Cortese JF; Estiu G; Galinsky K; Zuzarte-Luis V; Derbyshire ER; et al. "The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.". (2015): http://europepmc.org/abstract/med/25995223.
    10.1126/scitranslmed.aaa3575
  37. Mancio-Silva L; Mota MM. "A mediator for malaria stickiness in A versus O blood.". (2015): http://europepmc.org/abstract/med/25849268.
    10.1038/nm.3837
  38. Peter Liehl; Patrícia Meireles; Inês S. Albuquerque; Mykola Pinkevych; Fernanda Baptista; Maria M. Mota; Miles P. Davenport; Miguel Prudêncio; J. H. Adams. "Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections". Infection and Immunity 83 3 (2015): 1172-1180. http://dx.doi.org/10.1128/IAI.02796-14.
    10.1128/IAI.02796-14
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  80. Douradinha B; Augustijn KD; Moore SG; Ramesar J; Mota MM; Waters AP; Janse CJ; Thompson J. "Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host.". (2011): http://europepmc.org/abstract/med/21453484.
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  102. Ono T; Cabrita-Santos L; Leitao R; Bettiol E; Purcell LA; Diaz-Pulido O; Andrews LB; et al. "Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection.". (2008): http://europepmc.org/abstract/med/18389080.
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  117. Leiriao, P.; Mota, M.M.; Rodriguez, A.. "Reply to Rénia et al. [2]". Journal of Infectious Diseases 193 1 (2006): 164-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-29744439712&partnerID=MN8TOARS.
    10.1086/498537
  118. Franke-Fayard B; Janse CJ; Cunha-Rodrigues M; Ramesar J; Büscher P; Que I; Löwik C; et al. "Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration.". (2005): http://europepmc.org/abstract/med/16051702.
    10.1073/pnas.0503386102
  119. van Dijk MR; Douradinha B; Franke-Fayard B; Heussler V; van Dooren MW; van Schaijk B; van Gemert GJ; et al. "Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells.". (2005): http://europepmc.org/abstract/med/16103357.
    10.1073/pnas.0500925102
  120. Leiriao P; Mota MM; Rodriguez A. "Apoptotic Plasmodium-infected hepatocytes provide antigens to liver dendritic cells.". (2005): http://europepmc.org/abstract/med/15838783.
    10.1086/429635
  121. Leirião P; Albuquerque SS; Corso S; van Gemert GJ; Sauerwein RW; Rodriguez A; Giordano S; Mota MM. "HGF/MET signalling protects Plasmodium-infected host cells from apoptosis.". (2005): http://europepmc.org/abstract/med/15760460.
    10.1111/j.1462-5822.2004.00490.x
  122. Waters AP; Mota MM; van Dijk MR; Janse CJ. "Parasitology. Malaria vaccines: back to the future?". (2005): http://europepmc.org/abstract/med/15681372.
    10.1126/science.1108598
  123. Mota MM; Rodriguez A. "Migration through host cells: the first steps of Plasmodium sporozoites in the mammalian host.". (2004): http://europepmc.org/abstract/med/15527491.
    10.1111/j.1462-5822.2004.00460.x
  124. Leirião P; Rodrigues CD; Albuquerque SS; Mota MM. "Survival of protozoan intracellular parasites in host cells.". (2004): http://europepmc.org/abstract/med/15577928.
    10.1038/sj.embor.7400299
  125. Mota MM; Giordano S; Rodriguez A. "Targeting Plasmodium host cells: survival within hepatocytes.". (2004): http://europepmc.org/abstract/med/15464448.
    10.1016/j.molmed.2004.08.003
  126. Sanchez BA; Mota MM; Sultan AA; Carvalho LH. "Plasmodium berghei parasite transformed with green fluorescent protein for screening blood schizontocidal agents.". (2004): http://europepmc.org/abstract/med/15013738.
    10.1016/j.ijpara.2003.11.011
  127. Mota, M.M.. "Malaria sporozoite: Migrating for a living - A response". Trends in Molecular Medicine 10 3 (2004): 100-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-1442323839&partnerID=MN8TOARS.
    10.1016/j.molmed.2004.01.011
  128. Carrolo M; Giordano S; Cabrita-Santos L; Corso S; Vigário AM; Silva S; Leirião P; et al. "Hepatocyte growth factor and its receptor are required for malaria infection.". (2003): http://europepmc.org/abstract/med/14556002.
    10.1038/nm947
  129. Ocaña-Morgner C; Mota MM; Rodriguez A. "Malaria blood stage suppression of liver stage immunity by dendritic cells.". (2003): http://europepmc.org/abstract/med/12538654.
    10.1084/jem.20021072
  130. Mota, M.M.; Hafalla, J.C.R.; Rodriguez, A.. "Erratum: Migration through host cells activates Plasmodium sporozoites for infection (Nature Medicine (2002) 8 (1318-1322))". Nature Medicine 9 1 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037234456&partnerID=MN8TOARS.
    10.1038/nm0103-146a
  131. Mota MM; Hafalla JC; Rodriguez A. "Migration through host cells activates Plasmodium sporozoites for infection.". (2002): http://europepmc.org/abstract/med/12379848.
    10.1038/nm785
  132. Delrieu I; Waller CC; Mota MM; Grainger M; Langhorne J; Holder AA. "PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes.". (2002): http://europepmc.org/abstract/med/11985859.
    10.1016/S0166-6851(02)00016-6
  133. Mota MM; Rodriguez A. "Invasion of mammalian host cells by Plasmodium sporozoites.". (2002): http://europepmc.org/abstract/med/11835279.
    10.1002/bies.10050
  134. Mota MM; Rodriguez A. "Migration through host cells by apicomplexan parasites.". (2001): http://europepmc.org/abstract/med/11709293.
    10.1016/S1286-4579(01)01473-3
  135. Natarajan R; Thathy V; Mota MM; Hafalla JC; Ménard R; Vernick KD. "Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: a new tool to study mosquito and mammalian host interactions with malaria parasites.". (2001): http://europepmc.org/abstract/med/11422080.
    10.1046/j.1462-5822.2001.00117.x
  136. Mota MM; Brown KN; Do Rosário VE; Holder AA; Jarra W. "Antibody recognition of rodent malaria parasite antigens exposed at the infected erythrocyte surface: specificity of immunity generated in hyperimmune mice.". (2001): http://europepmc.org/abstract/med/11254617.
    10.1128/IAI.69.4.2535-2541.2001
  137. Mota MM; Thathy V; Nussenzweig RS; Nussenzweig V. "Gene targeting in the rodent malaria parasite Plasmodium yoelii.". (2001): http://europepmc.org/abstract/med/11295181.
    10.1016/S0166-6851(01)00228-6
  138. Matuschewski K; Mota MM; Pinder JC; Nussenzweig V; Kappe SH. "Identification of the class XIV myosins Pb-MyoA and Py-MyoA and expression in Plasmodium sporozoites.". (2001): http://europepmc.org/abstract/med/11166399.
    10.1016/S0166-6851(00)00360-1
  139. Mota, M.M.; Pradel, G.; Vanderberg, J.P.; Hafalla, J.C.R.; Frevert, U.; Nussenzweig, R.S.; Nussenzweig, V.; Rodriguez, A.. "Migration of Plasmodium sporozoites through cells before infection". Science 291 5501 (2001): 141-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035808562&partnerID=MN8TOARS.
    10.1126/science.291.5501.141
  140. Mota, M.M.; Rodríguez, A.. "Plasmodium invasion of mosquito cells: hawk or dove? Response from Mota and Rodríguez". Trends in Parasitology 17 5 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0035005943&partnerID=MN8TOARS.
  141. Mota MM; Rodriguez A. "Plasmodium yoelii: efficient in vitro invasion and complete development of sporozoites in mouse hepatic cell lines.". (2000): http://europepmc.org/abstract/med/11162379.
    10.1006/expr.2000.4570
  142. Mota, M.M.; Jarra, W.; Hirst, E.; Patnaik, P.K.; Holder, A.A.. "Plasmodium chabaudi-infected erythrocytes adhere to CD36 and bind to microvascular endothelial cells in an organ-specific way". Infection and Immunity 68 7 (2000): 4135-4144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033918169&partnerID=MN8TOARS.
    10.1128/IAI.68.7.4135-4144.2000
  143. Mota, M.M.; Jarra, W.. "More on adaptive or innate resistance to Plasmodium [4]". Parasitology Today 15 5 (1999): http://www.scopus.com/inward/record.url?eid=2-s2.0-0032926201&partnerID=MN8TOARS.
  144. Mota, M.M.; Brown, K.N.; Holder, A.A.; Jarra, W.. "Acute Plasmodium chabaudi chabaudi malaria infection induces antibodies which bind to the surfaces of parasitized erythrocytes and promote their phagocytosis by macrophages in vitro". Infection and Immunity 66 9 (1998): 4080-4086. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031719250&partnerID=MN8TOARS.
Capítulo de livro
  1. Götz, A.; Ty, M.; Chora, A.F.; Zuzarte-Luís, V.; Mota, M.M.; Rodriguez, A.. "Innate immunity to malaria". 3-25. 2017.
Livro
  1. Mota, M.M.; Rodriguez, A.. Malaria: Immune response to infection and vaccination. 2017.
    10.1007/978-3-319-45210-4
  2. Sinnis, P.; De La Vega, P.; Coppi, A.; Krzych, U.; Mota, M.M.; Sinnis P; De La Vega P; et al. Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry. 2013.
    10.1007/978-1-62703-26-7_27
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018 - 2024/01/05 A Metabolic Arms Race Between Host and Parasite: Amino Acid Sensing and Response in Plasmodium
Coorientador
 Biologia Básica e Aplicada (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2022/10/04 Microbiota: Understanding its role in the Host-Plasmodium affair
Orientador
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/01/01 - 2021/07/30 Endosomal dynamics at the Host-Plasmodium interface through liver-stage parasite development
Orientador de Aparajita Lahree
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2020 Uncovering the UIS4 protein interacting network and its role during the malaria liver stage infection.
Orientador de Viriato M'Bana
 Ciências Biomédicas (Parasitologia/Microbiologia) (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015 Characterizing Iron transporters in Plasmodium species
Coorientador de Aparajita Lahree
Mestrado em Biologia Molecular e Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2013 The Liver Endoplasmic Reticulum response in Malaria Liver infection
Orientador de Patrícia Inácio
 Doutoramento em Biologia (Biologia Celular) (Doutoramento)
Universidade Nova de Lisboa, Portugal
2008 - 2012 Probing the role of host lipids during hepatocyte infection by malaria parasite
Orientador de Maurice Itoe
 Doutoramento em Ciências Biomédicas (Ciências Biopatológicas) (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2006 - 2010 Interactions of Plasmodium blood and liver stages within a single host
Orientador de Sílvia Portugal
Ciências Biomédicas (Ciências Biopatológicas) (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2006 - 2010 Plasmodium fitness: The importance of being prepared. Plasmodium sporozoites post-transcriptional regulation of gene expression and host cell cytoskeleton dynamics during Plasmodium intra-hepatic development.
Orientador de Carina Gomes-Santos
Doutoramento em Biologia Celular
Universidade de Coimbra, Portugal
2007 - 2008 Plasmodium infection of mammalian host: effects of vitamin D
Orientador de Nuno Baltazar do Carmo
Mestrado em Microbiologia Clínica (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2003 - 2007 The role of VEGF during a malaria infection
Orientador de Marta Campos
Doutoramento em Biologia (Biologia Molecular) (Doutoramento)
Universidade Nova de Lisboa, Portugal
2003 - 2007 Characterization of host cell response to Plasmodium infection: identification of hepatocyte genes involved in parasite development
Orientador de Sónia Albuquerque
Doutoramento em Ciências Biomédicas
Universidade do Porto, Portugal
2002 - 2007 Revealing host factors important for hepatocyte infection by Plasmodium
Orientador de Cristina Rodrigues
Doutoramento em Biologia (Biologia Celular) (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2007 Approaching host targets in murine malaria
Orientador de Margarida Cunha-Rodrigues
Doutoramento em Ciências Biomédicas
Universidade do Porto, Portugal
2002 - 2006 Plasmodium-Hepatocyte interactions: implications for protection against Malaria
Orientador de Patrícia Leirião
Doutoramento em Ciências Biomédicas (Parasitologia)
Universidade Nova de Lisboa, Portugal
2002 - 2006 Immunization with mutant Plasmodium parasites: how is that achieved?
Orientador de Bruno Douradinha
 Doutoramento em Ciências Biomédicas (Ciências Biopatológicas)
Universidade de Lisboa Faculdade de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018/06/24 - 2018/06/27 EMBO|EMBL symposia. Innate Immunity in Host-Pathogen Interactions. Scientific Organizer. (2018/06/24 - 2018/06/27)
Simpósio (Membro da Comissão Organizadora)
2015/06 - 2015/06 Biology of Sporozoites and Liverstages, Gordon Research Conferences - Translating Malaria Research to the Field, Girona, Spain - Conference Vice-Chair, Session Discussion Leader (2015/06 - 2015/06)
Conferência (Outra)
2015/05 - 2015/05 11th Biomalpar /Evimalar Conference - Biology and Pathology of the Malaria Parasite, EMBL, Heidelberg, Germany - Scientific Organizer (2015/05 - 2015/05)
Conferência (Coorganizador)
2010 - 2010 Malarial Disease: Contribution of Host Response - at the Keystone Symposia “Malaria: New Approaches to Understanding Host-Parasite Interactions”, Colorado - Chair of the Scientific Session (2010 - 2010)
Simpósio (Outra)
2007 - 2007 Malaria at the 13th International Congress of Immunology. Rio de Janeiro, Brazil - Chair of the Scientific Session (2007 - 2007)
Congresso (Outra)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2010 - Atual Cellular Microbiology (1462-5822) Wiley (Blackwell Publishing)
2008 - Atual PLoS Pathogens (1553-7374) Public Library of Science
2007 - Atual International Journal for Parasitology (0020-7519) Elsevier

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2008 - Atual Ad hoc reviewer for ESF
2006 - Atual Ad hoc reviewer for MRC Fellowships - UK
2005 - Atual Ad hoc reviewer and evaluation panel for Wellcome Trust - UK
Outro
 Wellcome Trust, Reino Unido
2013 - 2015 Member of CNCT – National Council of Science and Technology (Board of Advisers to the Portuguese Government)
Membro
2010 - 2010 Evaluation panel of NIH International Centers of Excellence for Malaria Research
2005 - 2006 Evaluation panel life sciences / health sciences FP6 – EU
Distinções

Prémio

2019 Prémio Dona Antónia Adelaide Ferreira - Career Achievement Award
Porto Ferreira - Sogrape, Portugal
2018 Sanofi – Institut Pasteur International Mid-Career Award in microbiology & infection
2017 Pfizer Award in Basic Research
2013 Prémio Pessoa
2011 Prémio BES de Inovação
2009 Prémio Saúde
2009 Prémio Rotary Investigação-Ciência
Rotary Club, Portugal
2008 Prémio Amélia da Silva de Mello para as Ciências da Saúde
2007 Seeds of Science Award
Ciência Hoje, Portugal
2007 Prémio Internacional de Investigação CESPU
Cooperativa de Ensino Superior Politécnico e Universitário Escola Universitária de Bragança, Portugal
2004 European Young Investigator Award (EURYI)
European Science Foundation, França
2003 Young Investigator Award

Outra distinção

2016 EMBO Member
2005 Comendadora da Ordem do Infante D. Henrique
2005 Howard Hughes Scholar
Howard Hughes Medical Institute, Estados Unidos