Akhilesh Rai (3519-CD06-4243)

Curriculum Vitae

Akhilesh Rai

Akhilesh Rai has completed Bachelor's (B.Sc.) in Chemistry and Botany, Chemistry from Deen Dayal Upadhyay Gorakhpur University, Master's (M.Sc.) in Biotechnology from Savitribai Phule Pune University and PhD in Biotechnology from Savitribai Phule Pune University. After completing his PhD, he moved to Nottingham Trent University, U.K. to pursue postdoctoral research on European Union FP7 project. In 2010, he moved to Universite Catholique Louvain as a postdoctoral researcher for 1 year. In 2012, he joined as FCT postdoctoral fellow at the Centre for Neuroscience and Cell Biology, Coimbra, Portugal. He was an assistant investigator at the Centre for Neuroscience and Cell Biology from 2013 to 2017 in the project led by Dr. Lino Ferreira. He was awarded the FCT Investigator grant and joined the Faculty of Medicine, University of Coimbra to start his independent group in November 2017. Notably, his team received the first prize at the first phase of the 7th Building Global Innovators (BGI-MIT Program) for the project related to developing a unique wound dressing for treating chronic wounds, which led to the generation of the spinoff company (CureMat Technology). Our work related to antimicrobial nanoparticles has been recognized and I have been conferred the prestigious Bluepharma-University of Coimbra Innovation award (2016) for the project Bug-killer. He has published more than 36 papers in international peer-reviewed journals, 5 book chapters, 1 patent granted (2 patents submitted at PCT level) with citations of more than 7000 and h-index-21. he has edited one book for the Elsevier group and currently editing another book for Springer Nature. He is also an active reviewer of many international journals related to nanotechnology, biodegradable NPs, antimicrobial materials, drug delivery, and antimicrobial surfaces. He supervised 2 PhD students and 8 master students for their theses. Currently, his group has two master's, two PhD students and one postdoctoral researcher. He has actively participated in several international conferences. He is guest editor of the special issues of Nanomaterials and (MDPI publishers) and Frontiers in Nanotechnology, and an associate editor of Frontiers of Medical Engineering. His research interests include the formulation of bioactive and peptide-conjugated nanomaterials and multifunctional coatings in treating oral infections and for regenerative medicine applications. His research group is also involved in the development of light-sensitive nanoparticles for brain targeting and understanding the paracrine effects on the integrity of the blood-brain barrier. His research group is also involved in the development of antimicrobial and bioactive coating on medical devices and implants. Recently, he is granted an FCT project to develop multifunctional dental implants for the treatment of peri-implant diseases. He is a team member of BioRobotbeads and Reset_Bone_Ageing projects funded by the regional fund (Centro2020 Portugal).

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Identificação

Identificação pessoal

Nome completo: Akhilesh Rai

Nomes de citação

Rai, Akhilesh

Identificadores de autor

Ciência ID: 3519-CD06-4243
ORCID iD: 0000-0001-5352-5415

Endereços de correio eletrónico

akhilesh.rai@uc.pt (Profissional)

Moradas

UC-Biotech, 3060-194, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

http://erachair.uc-biotech.pt (Profissional)

Domínios de atuação

Ciências da Engenharia e Tecnologias - Nanotecnologia
Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Hindi (Idioma materno)
Português	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2020/11/09 - 2020/11/20 Concluído	IV Modular training in Laboratory Animal Science (Outros) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2003/01/23 - 2007/12/19 Concluído	Biotechnology (Doctor of Philosophy) Especialização em Especialidade: Biotecnologia Savitribai Phule Pune University, Índia "Size and shape controlled synthesis of metal nanoparticles and its nanocomposites " (TESE/DISSERTAÇÃO)	Aprovado com distinção e louvor
2000/08/01 - 2002/06/30 Concluído	Biotechnology (Master) Especialização em Biotechnology Savitribai Phule Pune University Department of Biotechnology, Índia	First class
1996/07/01 - 1999/05/31 Concluído	ChemistryBotany, Zoology (Bachelor) Especialização em Chemistry and Botany Deen Dayal Upadhyay Gorakhpur University, Índia	Second class

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2017/11/01 - Atual	Investigador Auxiliar (carreira) (Investigação)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Faculdade de Medicina, Portugal
2016/11/01 - 2017/10/31	Investigador Auxiliar Convidado (carreira) (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/09/01 - 2015/09/30	Investigador Auxiliar (carreira) (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2011/04 - 2012/08	Postdoctoral researcher	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/02/02 - 2011/01/31	Postdoctoal researcher	Université catholique de Louvain Faculté des sciences, Bélgica
	Université catholique de Louvain Faculté des sciences, Bélgica
2007 - 2009	Postdoctoral researcher	Nottingham Trent University, Reino Unido
	Nottingham Trent University - Clifton Campus, Reino Unido

Projetos

Bolsa

	Designação	Financiadores
2021/10/01 - Atual	Biorobotbead_ Sistema robotizado para a produção de biomateriais e partículas 47081 team member	European Regional Development Fund Em curso
2021/10/01 - Atual	Reset Bone Ageing: Coating for orthopedic prostheses with the ability to increase bone tissue regeneration Reset_Bone_Ageing _069790 team member	European Regional Development Fund Em curso
2022/01/01 - 2024/12/31	Fabrication of light responsive and multifunctional dental implant for the treatment of peri-implant diseases PTDC/CTM-CTM/1719/2021 Investigador responsável Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2017 - 2022/10	NanoNeurogenic: Enhancing brain accumulation by nanoparticle chemistry (IF/00539/2015 Orientador Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012/11/01 - 2017	Triggerable nanomaterials to modulate cell activity info:eu-repo/grantAgreement/EC/FP7/307384/EU Outra	European Research Council Concluído
2010/06/01 - 2014	Antimicrobial coatings- Killmicrob info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105000/PT Investigador Pós-doutorado	Fundação para a Ciência e a Tecnologia

Projeto

	Designação	Financiadores
2014/12/01 - 2017	CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications info:eu-repo/grantAgreement/FCT/5665-PICT/137185/PT	Universidade do Algarve Faculdade de Ciências e Tecnologia Concluído
2013 - 2015	Stemcell based platforms for Regenerative and Therapeutic Medicine Centro-07-ST24-FEDER-002008 Investigador	Concluído
2011/04/01 - 2014	DEVELOPMENT OF ANTIMICROBIAL PEPTIDE-BASED COATINGS info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F732112%F2010/PT	Fundação para a Ciência e a Tecnologia Concluído
2010 - 2011	Conception de revetements (bio) organiques nano-et micro-structurés pour l'etude de l'adhésion bactérienne 885.324.344 Bolseiro de Pós-Doutoramento	Fonds de la Recherche Scientific Concluído

Outro

	Designação	Financiadores
2012/03/15 - 2015	NANOECOTOX-Impacts of metal nanoparticles to aquatic ecosystems: from community responses to cellular targets info:eu-repo/grantAgreement/FCT/COMPETE/121650/PT	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista	Rafaela Ferrao; Simoes, Susana MN; Lino Ferreira; Rai, Akhilesh. "Effect of near-infrared light-responsive and non-immunogenic nanoparticles on the integrity of the blood-brain barrier and their accumulation in the brain". Biomaterials Advances (2023): Submetido Rai, Akhilesh; Sahadevan Seena; Gagliardi, Teresa; Palma, Paulo J.. Autor correspondente: Rai, Akhilesh. "Advances in design of amino acid and peptide synthesized gold nanoparticles for their applications". Advances in Colloid and Interface Science (2023): Diogo, Patrícia; Amparo F. Faustino, M.; Palma, Paulo J; Rai, Akhilesh; Graça P. M. S. Neves, Maria; Miguel Santos, João. "May carriers at nanoscale improve the Endodontic’s future?". Advanced Drug Delivery Reviews 195 (2023): 114731. http://dx.doi.org/10.1016/j.addr.2023.114731. 10.1016/j.addr.2023.114731 Sahadevan Seena; Rafaela Ferrao; Melike Pala; S.L.K.W. Roelants; Wim Soetaert; Christian V. Stevens; Lino Ferreira; Rai, Akhilesh. Autor correspondente: Rai, Akhilesh. "Acidic sophorolipid and antimicrobial peptide based formulation as antimicrobial and antibiofilm agents". Biomaterials Advances (2023): https://www.sciencedirect.com/science/article/abs/pii/S2772950823000225. Publicado Akhilesh Rai; Rafaela Ferrão; Denise Marta; Andreia Vilaça; Miguel Lino; Tiago Rondão; Jian Ji; Artur Paiva; Lino Ferreira. "Antimicrobial Peptide-Tether Dressing Able to Enhance Wound Healing by Tissue Contact". ACS Applied Materials & Interfaces (2022): https://doi.org/10.1021/acsami.2c06601. 10.1021/acsami.2c06601 Akhilesh Rai; Rafaela Ferrão; Paulo Palma; Tatiana Patricio; Paula Parreira; Elsa Anes; Chiara Tonda-Turo; et al. "Antimicrobial peptide-based materials: opportunities and challenges". Journal of Materials Chemistry B 10 14 (2022): 2384-2429. https://doi.org/10.1039/D1TB02617H. No prelo • 10.1039/D1TB02617H Rai, Akhilesh; Ferreira, Lino. "Biomedical applications of the peptide decorated gold nanoparticles". Critical Reviews in Biotechnology 41 2 (2021): 186-215. http://dx.doi.org/10.1080/07388551.2020.1853031. 10.1080/07388551.2020.1853031 Luís Estronca; Vitor Francisco; Patrícia Pitrez; Inês Honório; Lara Carvalho; Helena Vazão; Josephine Blersch; et al. "Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions". Nanoscale Horizons (2021): https://doi.org/10.1039/D0NH00550A. 10.1039/D0NH00550A Michela Comune; Akhilesh Rai; Paulo Palma; Chiara TondaTuro; Lino Ferreira. "Antimicrobial and pro-angiogenic properties of soluble and nanoparticle-immobilized LL37 peptides". Biomaterials Science (2021): https://doi.org/10.1039/D1BM01034D. 10.1039/D1BM01034D Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez, Adrián; Antunes, Helena; Pinto, Sandra; Simoes, Susana MN; Rai, Akhilesh; Ferreira, Lino. "A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1A (HIF-1A)". Nanoscale 12 (2020): 9935-9942. http://dx.doi.org/10.1039/c9nr10503d. 10.1039/c9nr10503d Querido, Micaela M.; Felgueiras, Helena P.; Rai, Akhilesh; Costa, Fabíola; Monteiro, Claudia; Borges, Inês; Oliveira, Diana; Ferreira, Lino; Martins, Maria Cristina Lopes. "Cecropin-Melittin Functionalized Polyurethane Surfaces Prevent Staphylococcus epidermidis Adhesion without Inducing Platelet Adhesion and Activation". Advanced Materials Interfaces 5 24 (2018): 1801390. http://dx.doi.org/10.1002/admi.201801390. Aceite para publicação • 10.1002/admi.201801390 Ferreira, André F.; Comune, Michela; Rai, Akhilesh; Ferreira, Lino; Simões, Pedro N.. "Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics". The Journal of Physical Chemistry B 122 35 (2018): 8359-8366. http://dx.doi.org/10.1021/acs.jpcb.8b05717. Aceite para publicação • 10.1021/acs.jpcb.8b05717 Praça, Catarina; Rai, Akhilesh; Santos, Tiago; Cristovão, Ana C.; Pinho, Sonia L.; Cecchelli, Romeo; Dehouck, Marie-Pierre; Bernardino, Liliana; Ferreira, Lino S.. "A nanoformulation for the preferential accumulation in adult neurogenic niches". Journal of Controlled Release 284 (2018): 57-72. http://dx.doi.org/10.1016/j.jconrel.2018.06.013. Aceite para publicação • 10.1016/j.jconrel.2018.06.013 Saraiva, Cláudia; Talhada, Daniela; Rai, Akhilesh; Ferreira, Raquel; Ferreira, Lino; Bernardino, Liliana; Ruscher, Karsten. "MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo". PLOS ONE 13 3 (2018): e0193609. http://dx.doi.org/10.1371/journal.pone.0193609. Aceite para publicação • 10.1371/journal.pone.0193609 Michela Comune; Akhilesh Rai; Kiran K. Chereddy; Sandra Pinto; Sezin Aday; André F. Ferreira; Alessandra Zonari; et al. "Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential". Journal of Controlled Release 262 (2017): 58-71. https://doi.org/10.1016/j.jconrel.2017.07.007. 10.1016/j.jconrel.2017.07.007 Ferreira, A.F.; Rai, A.; Ferreira, L.; Simões, P.N.. "Findings on the interaction of the antimicrobial peptide cecropin-melittin with a gold surface from molecular dynamics studies". European Biophysics Journal 46 3 (2017): 247-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979994138&partnerID=MN8TOARS. 10.1007/s00249-016-1160-z Maleki, H.; Rai, A.; Pinto, S.; Evangelista, M.; Cardoso, R.M.S.; Paulo, C.; Carvalheiro, T.; et al. "High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core-Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide". ACS Applied Materials and Interfaces 8 18 (2016): 11366-11378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974846183&partnerID=MN8TOARS. 10.1021/acsami.6b03355 Rai, A.; Pinto, S.; Velho, T.R.; Ferreira, A.F.; Moita, C.; Trivedi, U.; Evangelista, M.; et al. "One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model". Biomaterials 85 (2016): 99-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958212359&partnerID=MN8TOARS. 10.1016/j.biomaterials.2016.01.051 Rai, Akhilesh; Prabhune, Asmita; Perry, Carole C.. "Entrapment of commercially important invertase in silica particles at physiological pH and the effect of pH and temperature on enzyme activity". Materials Science and Engineering: C 32 4 (2012): 785-789. http://dx.doi.org/10.1016/j.msec.2012.01.026. Aceite para publicação • 10.1016/j.msec.2012.01.026 Rai, A.; Perry, C.C.. "Mussel adhesive protein inspired coatings: A versatile method to fabricate silica films on various surfaces". Journal of Materials Chemistry 22 11 (2012): 4790-4796. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857508380&partnerID=MN8TOARS. 10.1039/c2jm15810h Hickman, G.J.; Rai, A.; Boocock, D.J.; Rees, R.C.; Perry, C.C.. "Fabrication, characterisation and performance of hydrophilic and super-hydrophilic silica as cell culture surfaces". Journal of Materials Chemistry 22 24 (2012): 12141-12148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862217742&partnerID=MN8TOARS. 10.1039/c2jm31161e Rai, A.; Perry, C.C.. "Facile fabrication of uniform silica films with tunable physical properties using silicatein protein from sponges". Langmuir 26 6 (2010): 4152-4159. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952966218&partnerID=MN8TOARS. 10.1021/la903366a Rai, A.; Perry, C.C.. "Fabrication of tuneable thickness silica films on solid surfaces using amines and proteins". Silicon 1 2 (2009): 91-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957923654&partnerID=MN8TOARS. 10.1007/s12633-009-9012-4 Rai, A.; Chaudhary, M.; Ahmad, A.; Bhargava, S.; Sastry, M.. "Synthesis of triangular Au core-Ag shell nanoparticles". Materials Research Bulletin 42 7 (2007): 1212-1220. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247473125&partnerID=MN8TOARS. 10.1016/j.materresbull.2006.10.019 Rai, A.; Singh, A.; Ahmad, A.; Sastry, M.; Rai, Akhilesh. "Role of halide ions and temperature on the morphology of biologically synthesized gold nanotriangles". Langmuir 22 2 (2006): 736-741. http://www.scopus.com/inward/record.url?eid=2-s2.0-31544434865&partnerID=MN8TOARS. 10.1021/la052055q Shankar, S.S.; Rai, A.; Ahmad, A.; Sastry, M.. "Controlling the optical properties of lemongrass extract synthesized gold nanotriangles and potential application in infrared-absorbing optical coatings". Chemistry of Materials 17 3 (2005): 566-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-13444291501&partnerID=MN8TOARS. 10.1021/cm048292g Shankar, S.S.; Rai, A.; Ahmad, A.; Sastry, M.. "Rapid synthesis of Au, Ag, and bimetallic Au core-Ag shell nanoparticles using Neem (Azadirachta indica) leaf broth". Journal of Colloid and Interface Science 275 2 (2004): 496-502. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942564380&partnerID=MN8TOARS. 10.1016/j.jcis.2004.03.003 Shankar, S.S.; Rai, A.; Ankamwar, B.; Singh, A.; Ahmad, A.; Sastry, M.. "Biological synthesis of triangular gold nanoprisms". Nature Materials 3 7 (2004): 482-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042832367&partnerID=MN8TOARS. 10.1038/nmat1152
Capítulo de livro	Sahadevan Seena; Rai, Akhilesh. Autor correspondente: Rai, Akhilesh. "Nanoengineering approaches to fight multidrug-resistant bacteria". In Non-traditional Approaches to Combat Antimicrobial Drug Resistance. 2023. Publicado Barros, Juliana; Rai, Akhilesh; Santosh Kumar; Sahadevan Seena. Autor correspondente: Sahadevan Seena. "Mega-challenges of nano-metals on micro-decomposers in freshwaters". In Nanoparticles and plant-microbe interactions: An environmental perspective, editado por Sahadevan Seena; Akhilesh Rai; Santosh Kumar. 2023. No prelo Rai, Akhilesh; Comune, Michela; Ferreira, Lino. "Nanoparticle-Based Drug Delivery Systems: Promising Approaches Against Bacterial Infections". In Antibacterial Drug Discovery to Combat MDR, 605-633. Portugal: Springer Singapore, 2019. Aceite para publicação • 10.1007/978-981-13-9871-1_27 Rai, Akhilesh. "Biocompatibility Issues of Organic and Inorganic Nanomaterials". In Frontiers in Biomaterials, 274-304. BENTHAM SCIENCE PUBLISHERS, 2014. Aceite para publicação • 10.2174/9781608058761114010013
Livro	Rai, Akhilesh; Sahadevan Seena. Nanoparticles and Plant-Microbe Interactions An Environmental Perspective. 2023. Publicado • Editor Rai, Akhilesh. Nanotechnology based Strategies for Combating Antimicrobial Resistance. Índia: Springer Nature. 2023. Em revisão • Editor
Poster em conferência	A. Sofia Pinho; Renato Pereira; Mariana G. Pereira; Rai, Akhilesh; Lino Ferreira; M. Cristina L. Martins; Paula Parreira. "The art of deceiving: lipid-based decoys for Helicobacter pylori infection management". Trabalho apresentado em XXXVIth Workshop of the European Helicobacter and Microbiota Study Group - EHMSG 2023, 2023. Rai, Akhilesh; Catarina Praca; Lino Ferreira. "Targeting the Neurogenic Niches of Adult Brain by Peptide Conjugated Nanoparticles". Trabalho apresentado em European Society of Biomaterials, 2018. Akhilesh Rai; Andre F. Ferreira; Lino Ferreira; Pedro N. Simões. "Molecular Dynamics Investigation Of The Interaction Of A Cecropin Melettin Peptide With Gold Surfaces". Trabalho apresentado em ChemPor, 2014. Rai, Akhilesh. "Halide ions mediated shape change in gold nanotriangles". Trabalho apresentado em International Conference on Nanoscience and Technology (ICONSAT 2006), 2006. Rai, Akhilesh. "Reshaping of gold nanoparticles using chemical means". Trabalho apresentado em International Nanotechnology and Biotechnology Conference (INBC 2006), 2006.
Resumo em conferência	Gagliardi, Teresa; Palma, Paulo J.; Chiara Tonda-Turo; Rai, Akhilesh. Autor correspondente: Rai, Akhilesh. "Light-responsive and multifunctional antimicrobial coatings to prevent peri-implantitis". Trabalho apresentado em European Society of Biomaterials 2023, Davos, 2023. Rai, Akhilesh. "Immobilization of Cecropin-melittin antimicrobial peptide onto polyurethane to prevent infections without inducing thrombus formation". Trabalho apresentado em 6th China-Europe Symposium on Biomaterials in Regenerative Medicine, Porto, 2017. Rai, Akhilesh. "Biocompatible antimicrobial peptide conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model". Trabalho apresentado em III Simposia De Nanociencia E Nanotechnologia Biomedica (Nano2016PT), Lisbon, 2016. Rai, Akhilesh. "Biocompatible antimicrobial peptide (AMP) conjugated gold nanoparticles with high stability against serum and protease". Trabalho apresentado em Eurpean Society of Biomaterials, 2013. Rai, Akhilesh. "An antimicrobial surface with potent antimicrobial activity and low cytotoxicity against human cells". Trabalho apresentado em European Biomaterials Society, Madrid, 2013. Rai, Akhilesh. "Cecropin-mellitin modified surfaces exhibit high antimicrobial activity and low cytotoxicity against human cells". Trabalho apresentado em Socienty for Biomaterials Spring meeting, 2013. Rai, Akhilesh. "Design of potent antimicrobial and biocompatible gold nanoparticles". Trabalho apresentado em NanoPT Conference, Porto, 2013. Rai, Akhilesh. "One pot synthesis of potent antimicrobial gold nanoparticles". Trabalho apresentado em Trends in Nanotechnology Conference, 2012. Rai, Akhilesh; Rai, A.; Prabhune, A.; Perry, C.C.. "Antibiotics mediated synthesis of gold nanoparticles with potent antimicrobial activity and their applications in antimicrobial coatings". Trabalho apresentado em Material Research Society (MRS) conference, 2010. 10.1039/c0jm00817f Rai, Akhilesh. "The facile fabrication of controlled thickness silica films on solid surfaces using a bio-inspired approach". Trabalho apresentado em Material Research Society (MRS) conference, 2009. Rai, Akhilesh. "Synthesis of Au-Ag core-shell nanoparticles and its application in SERS". Trabalho apresentado em International Conference on Nanomaterials (Nano 2005), Shivakshi, 2005.
Tese / Dissertação	Monteiro, Denise Irene Marta. "THERAPEUTIC EFFECTS OF NOVEL DRESSING COATED WITH LL37-AuNP FOR THE ENHANCED WOUND HEALING". Mestrado, Universidade de Coimbra Faculdade de Farmácia, 2019. http://hdl.handle.net/10316/88197. Rai, Akhilesh. "Wound healing and pro-angiogenic properties of LL37-conjugated nanoparticles". Doutoramento, 2015.

Propriedade Intelectual

Patente	Rai, Akhilesh. 2015. "Antimicrobial coating compositions".
Pedido provisório de patente	2021. "PROCESS TO COAT A MEDICAL DEVICE SURFACE WITH PEPTIDE-BASED NANOPARTICLES". Divulgado 2020. "CHOLESTEROL/ETHYLENE GLYCOL GOLD NANOPARTICULES FOR TREATMENT OF HELICOBACTER PYLORI INFECTION". Divulgado

Outros

Empresa spin-off

2018. CureMat Technology. Development of wound dressing.

Outra produção

High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells. Medical device-associated infections are a multi-billion dollar burden for the worldwide healthcare systems. The modification of medical devices with non-leaching coatings capable of killing microorganisms on contact is one of the strategies being investigated to prevent microorganism colonization. Here we developed a robust antimicrobial coating based on the chemical immobilization of the antimic. 2016. Rai, Akhilesh; Pinto, Sandra; Evangelista, Marta B.; Gil, Helena; Kallip, Silvar; Ferreira, Mario G. S.; Ferreira, Lino; et al. http://hdl.handle.net/10773/19977.
10.1016/j.actbio.2016.01.035

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/09	To reset the senescence program in senescent stem/progenitor cells by extracellular vesicles	European Society of Biomaterials 2023
2023/09	Light-responsive and multifunctional antimicrobial coatings to prevent peri-implantitis	European Society of Biomaterials 2023 (Davos, Suiça)
2023/06	Synergistic antimicrobial effect between antimicrobial peptides conjugated nanoparticles	European Society of Clinical Investigation (Prague, República Checa)
2022/09/04	Immunotoxicity caused by near-infrared light-responsive nanoparticles on the integrity of the blood-brain barrier	European Society of Biomaterials (França)
2022/08/12	Immunotoxicity evaluation of light-responsive nanoparticles to the integrity of blood-brain barrier model	International Online Conference on Nano Materials (ICN 2022) (Índia)
2022/07/19	Near-infrared light-responsive nanoparticles as an efficient carrier to cross the blood-brain barrier	Junior Euromat 2022 University of Coimbra (Coimbra)
2022/06/20	Antimicrobial peptide-based nanoformulations: Fight bacteria and promote tissue regeneration	8th International IBERIAN BIOPHYSICS CONGRESS Spanish Biophysical Society (Bilbao, Espanha)
2022/05/29	Design of antimicrobial peptide-based materials to fight infections and promote skin regeneration	5th Congress of the Hellenic Society of Gene Therapy and Regenerative Medicine Hellenic Society (Thessaloniki, Grécia)
2021/09/06	Peptide conjugated light-responsive NPs to target blood brain barrier	European Society of Biomaterials (Porto, Portugal)
2021/03/24	Peptide conjugated light-responsive NPs to target blood brain barrier	Drug Delivery Webinar (Reino Unido)
2021/03/24	Peptide decorated gold nanoparticles and their applications in wound healing and brain targeting	Faculty Development Programme on 'Nanomaterials for Next Generation Applications Indian Institute of technology Indore, India (Indore)
2019	Peptide conjugated nanoparticles and their biomedical applications	V Semana da Bioengenharia Instituto Superior Técnico (Lisbon, Portugal)
2019	Nanotechnology and Biomedical applications	VII AEICBAS Biomedical Congress University of Porto (Porto, Portugal)
2017/05/21	Antimicrobial peptide conjugated gold nanoparticles with their antimicrobial efficacy in systemic infection model	6th China-Europe Symposium on Biomaterials in Regenerative Medicine, 2017, Porto University of Porto (Porto, Portugal)
2017/05/17	Peptide conjugated nanoparticles and their biomedical applications	II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications Faculty of Health Sciences of University of Beira Interior (Covilhã, Portugal)
2017	Antimicrobial peptide conjugated gold nanoparticle with enhanced skin regeneration property	Portuguese Society for Stem Cells and Cell Biology University of Beira Interior (Covilha, Portugal)
2017	Targeting the Neurogenic Niches of Adult Brain by Nanoparticles	Portuguese Society of Stem Cells and Cell Biology University of Beira Interior (Covilha, Portugal)
2013	Design of potent antimicrobial and biocompatible gold nanoparticles	Nanoscience and Nanotechnology International Conference (NanoPT 2013) (Porto, Portugal)
2013	An antimicrobial surface with potent antimicrobial activity and low cytotoxicity against human cells	European Society of Biomaterials (Madrid, Espanha)
2013	Biocompatible antimicrobial peptide (AMP) conjugated gold nanoparticles with high stability against serum and proteases	European Society of Biomaterials (Madrid, Espanha)
2013	Cecropin-mellitin modified surfaces exhibit high antimicrobial activity and low cytotoxicity against human cells	ASB Spring meeting (Boston, Estados Unidos)
2012	Design of potent antimicrobial and biocompatible gold nanoparticles	Trends in Nanotechnology International Conference (TNT2012) (Madrid, Espanha)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2023/03/30 - Atual	Design of multifuctional dental implants to prevent per-implantitis Orientador	Universidade de Coimbra, Portugal
2022/09 - Atual	Molecular dynamics approach to understand the interaction of conjugated antimicrobial peptides with the bacterial memrbane Orientador	Chemical Enginering (Mestrado) Universidade de Coimbra, Portugal
2022/01 - Atual	Light-responsive NPs to deliver senolytic drugs to aged brain Orientador	Life Science (Doutoramento) Universidade de Coimbra, Portugal
2012 - Atual	Wound healing and pro-angiogenic properties of LL37-conjugated nanoparticles Coorientador	Bioscience in area of Biotechnology (Doutoramento)
2022/03/15 - 2022/10	Development of NIR light-responsive nanoparticles coating on implants to prevent infections Orientador	Chemistry (Mestrado) Universidade de Coimbra, Portugal
2021/09/01 - 2022/09	Antimicrobial materials for dental applications Coorientador	Biomedical Engineering (Mestrado) Universidade de Coimbra, Portugal
2019/05/01 - 2019/11/30	Development of antimicrobial nanofibers to treat dental infection Coorientador	Biomedical Engineering (Mestrado)
2019/05/01 - 2019/11/30	Antimicrobial nanofibers for dental regeneration and to control microbial infection Coorientador	Biomedical Engineering (Mestrado) Politecnico di Torino, Itália
2018/09/01 - 2019/09/06	Therapeutic effects of novel LL37-AuNPs coated dressing for the enhanced wound healing Orientador de Denise Marta	Pharmaceutical Biotechnology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2016 - Atual	Attended Entrepreneurship program at Building Global Innovation, (MIT-Portugal program), Lisbon 2016 Oficina (workshop)	Building Global Innovation

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2023/03 - Atual	European Society of Biomaterials 2023

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2022/12/01 - Atual	Frontiers in Medical Engineering
2021 - Atual	Journal of Applied Biopharmaceutics and Pharmacokinetics (2309-4435)	Scientific Array
2021 - Atual	Frontiers in Nanotechnology	Frontiers
2020/07/10 - Atual	Nanomaterials (2079-4991)	MDPI
2020/07/01 - Atual	Antibiotics (2079-6382)	MDPI AG

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2021/04 - Atual	I am a reviewer of European Society of Biomaterials 2021 and 2023 conferences to evaluate the submitted abstracts. Avaliador

Consultoria / Parecer

	Descrição da atividade	Instituição / Organização
2012 - Atual	NANOECOTOX-Impacts of metal nanoparticles to aquatic ecosystems: from community responses to cellular targets (Centre of Molecular and Environmental Biology) University of Minho, Braga.	Universidade do Minho, Portugal

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2019 - Atual	Biomedical Engineering 2019-2020	Biomedical Engineering (Mestrado integrado)	Universidade de Coimbra, Portugal
2019 - Atual	2018-2019	Biomedical Engineering (Mestrado integrado)	Universidade de Coimbra, Portugal
2019 - Atual	2019-2020	PhDBEB (Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Entrevista / Programa (rádio / tv)

	Programa	Tema
2023/03/20 - Atual	Olhó Robot" #16: International Brain Week: Drug delivery to the brain. Interviewed by Luís Pereira (available as podcast).

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2020 - Atual	I am a team member of Reviewer Board of Pharmaceutics Journal from MDPI group.
2017/12/01 - Atual	I am reviewers of several journals such as ACS Applied Materials & Interfaces, Acta Biomaterialia, Colloids & Surfaces B, Macromolecule Biosciences and other journals related to Nanobiotechnology.

Tutoria

	Tópico	Nome do aluno
2023/01/23 - Atual	Coating of dual antimcirobial peptide-conjugated NPs on surfaces	Diogo Cruz
2022/10/01 - Atual	Therapeutic. evaluation of multifunctional dental implants in vitro and in vivo model	Claudia Deus
2020/01 - Atual	Skin regeneration using light responsive NPs	Rafaela Ferrão
2021/03 - 2021/12	Brain targeting using near infrared light-sensitive NPs	Rafaela Ferrão
2019/07/09 - 2019/09/06	Synthesis of light sensitive nanoparticles for drug delivery application	Laressa Leite
2018/09/06 - 2019/08/10	Formulation of biodegradable nanoparticles (NPs) encapsulated with a senotherapeutic	Ana Cunha
2018/10/01 - 2018/11/06	To understand the mechanism of diabetic wound healing	Ana Costa
2018/04/04 - 2018/07/31	Development of antimicrobial wound dressing	Fabio Vidal
2018/03/05 - 2018/04/30	Formulation of biodegradable nanoparticles	Adelaide Barbosa
2016/12/01 - 2017/09/30	Development of biodegradable nanoformulation to deliver small molecules	Josephine Blersch

Distinções

Prémio

2017	FCT Investigator award
2015	Innovation award Bluepharma, Portugal Universidade de Coimbra, Portugal
2011	FCT postdoctoral fellowship Fundação para a Ciência e a Tecnologia, Portugal
2003	Junior Research Fellowship Council of Scientific & Industrial Research, Índia
2000	Fellowship Savitribai Phule Pune University Department of Biotechnology, Índia

Outra distinção

2018	Co founder