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Maria João Romão got her PhD in Chemistry in 1989 at Instituto Superior Técnico, Lisbon and was a AvHumboldt post-doctoral fellow at the Max Planck Institute for Biochemistry, Martinsried, Germany. She got her Habilitation in Biochemistry at Faculdade de Ciências e Tecnologia, NOVA University of Lisbon, in 2001 and since 2012 she is Full Professor of Biochemistry at the same University. She is the founding Director of the Research Unit on Applied Biomolecular Sciences, UCIBIO. Her research group on Macromolecular Crystallography (http://sites.fct.unl.pt/xtal) has several areas of interest focused on molybdoenzymes (aldehyde oxidases, arsenite oxidases and formate dehydrogenases) and their enzymatic mechanisms, glycan-binding and cellulosomal proteins and methods for protein crystallization. She has supervised/co-supervised 14 PhD thesis and is the Principal investigator in 7 project(s) and Researcher in 24 project(s). Since 2012 she is the Portuguese Delegate to the European Synchrotron Radiation Laboratory (ESRF), the Portuguese observer at the Scientific Advisory Committee of ALBA Synchrotron and, since 2017, Co-Editor of Acta Crystallographica F. She is co-author of over 150 SCI publications, 8 book chapters and her work has received 5610 citations, h-index= 41
Identificação

Identificação pessoal

Nome completo
Maria Joao Romão

Nomes de citação

  • Romão, Maria
  • Maria Joao Romao

Identificadores de autor

Ciência ID
3315-C689-4557
ORCID iD
0000-0002-3004-0543
Google Scholar ID
CRCXDwYAAAAJ
Researcher Id
A-4115-2013
Scopus Author Id
7004694870

Endereços de correio eletrónico

  • mjr@fct.unl.pt (Profissional)

Websites

  • https://novaresearch.unl.pt/en/persons/maria-jo%C3%A3o-rom%C3%A3o/publications/ (Profissional)
  • https://sites.fct.unl.pt/xtal (Académico)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2001/05/10
Concluído
Biochemistry (Título de Agregado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"n.a." (TESE/DISSERTAÇÃO)
n.a.
1989
Concluído
Chemistry (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
""Reacções de cetonas com carbenóides de lítio: estudos estruturais e mecanísticos"." (TESE/DISSERTAÇÃO)
Distinção e Louvor
1978
Concluído
Engenharia Quimica (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"n.a." (TESE/DISSERTAÇÃO)
16
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2012/06/01 - Atual Professor Catedrático (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1998/09/01 - 2012/05/30 Professor Associado (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1989/01/26 - 1998/09/02 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal
1979/01/02 - 1989/01/25 Assistente (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2014 - 2020 Conselho científico/técnico-científico ou orgão correspondente Universidade Nova de Lisboa, Portugal
2013/02/25 - 2017/11/14 President of the Chemistry Department Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2014/12/31 - Atual Director of the Research Unit on Applied Molecular Biosciences (UCIBIO) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1998/09/02 - Atual Group Leader - Structural Biology (Xtal@FCT-NOVA) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1992/02/01 - 1998/09/01 Group Leader - Macromolecular Crystallography Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - 2021/09/30 Detoxification of Hydrogen Peroxide by Pathogenic Bacteria - E.coli Tri-haem peroxidase as a model (Co-PI)
PTDC/BIA-BQM/29442/2017
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/09/30 Fighting Staphylococcus aureus - Peptidoglycan amidation as a new target
PTDC/BIA-MIC/31645/2017
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/09/16 Bacterial ABC-type Multitask Energizers: one ATPase fits all? (Co-PI)
PTDC/BIA-MIC/30696/2017
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/08/31 Glycan-human microbiome interaction: glycan diversity and recognition in the human gut with impact on health and nutrition
PTDC/BIA-MIB/31730/2017
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019/04/01 Targeting p53 family proteins: on the route to new anticancer agents
PTDC/DTP-FTO/1981/2014
grant.Provided by PTCRIS: 140607
Investigador
Universidade do Minho, Portugal

Universidade de Coimbra, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
2016 - 2019/01 Aldehyde Oxidases in Drug Metabolism and Biocatalysis: Searching for the Substrate Specificity and Catalytic Mechanism<br>
grant.Provided by PTCRIS: 139810
PTDC/BBB-BEP/1185/2014
Investigador responsável
Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
2016 - 2018/12 CtIncipedia – A multidisciplinary approach to study Chlamydia trachomatis inclusion membrane (Inc) proteins
grant.Provided by PTCRIS: 139925
PTDC/IMI-MIC/1300/2014
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
2016 - 2018/12 An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition (PI from Romao group)
grant.Provided by PTCRIS: 139494
PTDC/BBB-BEP/0869/2014
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
2015 - 2018/11 Reduction of CO2 for sustainable biofuel production
grant.Provided by PTCRIS: 141349
Investigador
Fundação para a Ciência e a Tecnologia
2013 - 2017/03/31 Modern Structural Biology: Resources for the advancement of in-house X-ray Crystallography (PI from Romao group)
RECI/BBB-BEP/0124/2012
grant.Provided by PTCRIS: 125363
Investigador
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
2013 - 2015/12/31 Amidation of the peptidoglycan of Gram-positive bacteria: an unexplored potential target for antibiotics
PTDC/BIA-MIC/3195/2012
Investigador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
2013 - 2015/12/31 ENZYMATIC CATALYSIS - seeking a global picture
EXCL/QEQ-COM/0394/2012
128544
Provided by PTCRIS: 128544
Investigador
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
2013 - 2015/04 Ionic liquid-based systems for protein crystallization
129159
Provided by PTCRIS: 129159
PTDC/BBB-BEP/3058/2012
Investigador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
2012 - 2015/01 Mammalian and Bacterial Aldehyde Oxidases: Structure, mechanism and insights into cofactor binding and protein maturation (PI from Romao group)
Provided by PTCRIS: 118377
118377
PTDC/BIA-PRO/118377/2010
Investigador
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
2010 - 2014/01 Engineered biomimetics for large-scale enrichment of phosphoproteins
Provided by PTCRIS: 102163
102163
PTDC/EBB-BIO/102163/2008
Investigador
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
2010 - 2013/06/30 Structure and function of novel Glycoside Hydrolases and Carbohydrate-Binding Modules of Clostridium thermocellum cellulosome
PTDC/BIA-PRO/103980/2008
103980
Provided by PTCRIS: 103980
Investigador
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2013/06 The Cellulosome assembly: structure, function and specificity of new cellulases and supramolecular complexes (PI from Romao group)
Provided by PTCRIS: 100359
100359
PTDC/QUI-BIQ/100359/2008
Investigador
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
2009 - 2012/09 Production of a stable form of human phenylalanine hydroxylase: towards the 3D structure determination.
64023
Provided by PTCRIS: 64023
PTDC/QUI/64023/2006
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
2009 - 2011/12/31 Structure and function of novel carbohydrate-binding modules and cohesin-dockerin protein complexes from Clostridium thermocellum
PTDC/BIA-PRO/69732/2006
69732
Provided by PTCRIS: 69732
Investigador
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
2008 - 2011/12/31 Structural characterization of mRNA localization mechanisms (PI from Romao group)
PTDC/BIA-PRO/80486/2006
80486
Provided by PTCRIS: 80486
Investigador
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
2008 - 2011/09 A combined approach of X-ray Crystallography, NMR and Computational Chemistry for the study of the molecular interactions that define the ligand specificity in cellulosomal Carbohydrate Binding Modules (PI from Romao group)
68286
Provided by PTCRIS: 68286
PTDC/QUI/68286/2006
Investigador
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
2008 - 2011/07/31 Structural and functional studies of the SOUL/HBP family of heme binding proteins
PTDC/QUI/64203/2006
64203
Provided by PTCRIS: 64203
Investigador
Universidade de Aveiro, Portugal

Universidade de Aveiro CICECO, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
2008 - 2011/06/30 Xanthine Oxidase-Related Enzymes: Structure, Function and Specificity
PTDC/QUI/64733/2006
64733
Provided by PTCRIS: 64733
Investigador responsável
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2009/06 New molybdo and copper cofactors in proteins isolated from sulfate reducers
Provided by PTCRIS: 82079
82079
55350
Provided by PTCRIS: 55350
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2009/04 Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes (PI from Romao group)
82210
Provided by PTCRIS: 82210
59118
Provided by PTCRIS: 59118
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2008/11 Structural and Functional Characterization of Nitrate Reductases and Formate Dehydrogenases
82151
Provided by PTCRIS: 82151
57641
Provided by PTCRIS: 57641
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2000 - 2004/03/31 HPRN-CT-1999-00084, The mechanism, specificity and inhibition of enzymes belonging to the xanthine oxidase family : medical and industrial applications (8 EU partners; PT coordinator)
HPRN-CT-1999-00084
Investigador responsável
Universidade Nova de Lisboa, Portugal
European Commission
2000 - 2004 A crystallographic contribution to the understanding of the structure and function of Mo-enzymes
POCTI/1999/BME/35078
POCTI/1999/BME/35078
Investigador responsável
Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
1999 - 2001 Molecular Biology and Structural Studies in Metalloproteins
PRAXIS/C/BIA/11089/1998
Investigador responsável
Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
1996 - 1999/10 BIO4-CT96-0413 “Construction of Novel Redox Proteins from modular building blocks” (5 EU Partners; PT coordinador)
BIO4-CT96-0413
Investigador responsável
Universidade Nova de Lisboa Departamento de Química, Portugal
European Commission
1993 - 1996 ID: CHRX930243 Pteridines: biosynthesis, regulation and pharmacology (7 EU participants; PT coordinator)
CHRX930243
Investigador responsável
Universidade Nova de Lisboa, Portugal
European Commission
Produções

Publicações

Artigo em revista
  1. Rita Lopes; Álvaro Raya-Barón; M. Paula Robalo; Carolina Vinagreiro; Barroso, S. B.; Maria João Romão; Ignacio Fernández; Mariette M. Pereira; Beatriz Royo. "Donor Functionalized Iron(II) N-Heterocyclic Carbene Complexes in Transfer Hydrogenation Reactions". European Journal of Inorganic Chemistry 2021 1 (2021): 22-29. https://novaresearch.unl.pt/en/publications/900706f4-c01a-48d2-bdda-0cddf2a442ac.
    10.1002/ejic.202000868
  2. Francisco Leisico; Lia M. Godinho; Inês C. Gonçalves; Sara P. Silva; Bruno Carneiro; Maria João Romão; Teresa Santos-Silva; Isabel de Sá-Nogueira. "Multitask ATPases (NBDs) of bacterial ABC importers type I and their interspecies exchangeability". Scientific Reports 10 1 (2020): https://novaresearch.unl.pt/en/publications/b85b8cce-c518-4679-9df5-43bc2d76931f.
    10.1038/s41598-020-76444-0
  3. Pedro Ferreira; Nuno M. F. Sousa A. Cerqueira; Pedro Alexandrino Fernandes; Maria João Romão; Maria João Ramos. "Catalytic Mechanism of Human Aldehyde Oxidase". ACS Catalysis 10 16 (2020): 9276-9286. https://novaresearch.unl.pt/en/publications/6743d222-2ae8-464c-84e0-fa6e282315d5.
    10.1021/acscatal.0c02627
  4. Ana Sara Gomes; Helena Ramos; Sara Gomes; Joana B. Loureiro; Joana Soares; Valentina Barcherini; Paola Monti; et al. "SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations". Biochimica et Biophysica Acta - General Subjects 1864 1 (2020): https://novaresearch.unl.pt/en/publications/835b29c1-bec5-44df-8a20-8167fd34ec7c.
    10.1016/j.bbagen.2019.129440
  5. Fernandes, A.R.; Mendonça-Martins, I.; Santos, M.F.A.; Raposo, L.R.; Mendes, R.; Marques, J.; Romão, C.C.; et al. "Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules". ACS Biomaterials Science and Engineering 6 2 (2020): 1090-1101. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079071744&partnerID=MN8TOARS.
    10.1021/acsbiomaterials.9b01936
  6. Oliveira, A.R.; Mota, C.; Mourato, C.; Domingos, R.M.; Santos, M.F.A.; Gesto, D.; Guigliarelli, B.; et al. "Toward the Mechanistic Understanding of Enzymatic CO2 Reduction". ACS Catalysis 10 6 (2020): 3844-3856. http://www.scopus.com/inward/record.url?eid=2-s2.0-85082073064&partnerID=MN8TOARS.
    10.1021/acscatal.0c00086
  7. Catarina Coelho; Jayaraman Muthukumaran; Teresa Santos-Silva; Maria João Romão. "Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio-informatics study". Pharmacology Research & Perspectives 7 6 (2019): https://doi.org/10.1002/prp2.538.
    10.1002/prp2.538
  8. Cristiano De Sousa Mota; Mariam Esmaeeli; Catarina Coelho; Teresa Santos-Silva; Martin Wolff; Alessandro Foti; Silke Leimkühler; Maria João Romão. "Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms". FEBS Open Bio 9 5 (2019): 925-934. https://novaresearch.unl.pt/en/publications/4ed52cd7-52c6-4de6-b539-1fecaa355682.
    10.1002/2211-5463.12617
  9. Martins, F.F.; Joseph, A.; Diogo, H.P.; Minas da Piedade, M.E.; Ferreira, L.P.; Carvalho, M.D.; Barroso, S.; et al. "Irreversible Magnetic Behaviour Caused by the Thermosalient Phenomenon in an Iron(III) Spin Crossover Complex". European Journal of Inorganic Chemistry 2018 25 (2018): 2976-2983. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049604005&partnerID=MN8TOARS.
    10.1002/ejic.201800605
  10. Mota, C.; Coelho, C.; Leimkühler, S.; Garattini, E.; Terao, M.; Santos-Silva, T.; Romão, M.J.. "Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics". Coordination Chemistry Reviews 368 (2018): 35-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046125951&partnerID=MN8TOARS.
    10.1016/j.ccr.2018.04.006
  11. Leisico, F.; Vieira, D.V.; Figueiredo, T.A.; Silva, M.; Cabrita, E.J.; Sobral, R.G.; Ludovice, A.M.; et al. "First insights of peptidoglycan amidation in Gram-positive bacteria-The high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044530342&partnerID=MN8TOARS.
    10.1038/s41598-018-22986-3
  12. Kowacz, Magdalena; Marchel, Mateusz; Juknaite, Lina; Esperanca, Jose M. S. S.; Romao, Maria Joao; Carvalho, Ana Luisa; Rebelo, Luis Paulo N.. "Infrared light-induced protein crystallization. Structuring of protein interfacial water and periodic self-assembly". Journal of Crystal Growth 457 (2017): 362-368. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000389590700063&KeyUID=WOS:000389590700063.
    10.1016/j.jcrysgro.2016.01.003
  13. Watson, C.; Niks, D.; Hille, R.; Vieira, M.; Schoepp-Cothenet, B.; Marques, A.T.; Romão, M.J.; Santos-Silva, T.; Santini, J.M.. "Electron transfer through arsenite oxidase: Insights into Rieske interaction with cytochrome c". Biochimica et Biophysica Acta - Bioenergetics 1858 10 (2017): 865-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027491816&partnerID=MN8TOARS.
    10.1016/j.bbabio.2017.08.003
  14. Pires, V.M.R.; Pereira, P.M.M.; Brás, J.L.A.; Correia, M.; Cardoso, V.; Bule, P.; Alves, V.D.; et al. "Stability and ligand promiscuity of type A carbohydrate-binding modules are illustrated by the structure of Spirochaeta thermophila StCBM64C". Journal of Biological Chemistry 292 12 (2017): 4847-4860. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016255875&partnerID=MN8TOARS.
    10.1074/jbc.M116.767541
  15. Romão, M.J.; Coelho, C.; Santos-Silva, T.; Foti, A.; Terao, M.; Garattini, E.; Leimkühler, S.. "Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics". Current Opinion in Chemical Biology 37 (2017): 39-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010465431&partnerID=MN8TOARS.
    10.1016/j.cbpa.2017.01.005
  16. Serrano, J.L.; Cavalheiro, E.; Barroso, S.; Romão, M.J.; Silvestre, S.; Almeida, P.. "A synthetic route to novel 3-substituted-2,1-benzisoxazoles from 5-(2-nitrobenzylidene)(thio)barbiturates". Comptes Rendus Chimie 20 11-12 (2017): 990-995. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034619355&partnerID=MN8TOARS.
    10.1016/j.crci.2017.10.002
  17. Polino, M.; Carvalho, A.L.; Juknaite, L.; Portugal, C.A.M.; Coelhoso, I.M.; Romão, M.J.; Crespo, J.G.. "Ion-Exchange Membranes for Stable Derivatization of Protein Crystals". Crystal Growth and Design 17 9 (2017): 4563-4572. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028995862&partnerID=MN8TOARS.
    10.1021/acs.cgd.7b00315
  18. Foti, Alessandro; Hartmann, Tobias; Coelho, Catarina; Santos-Silva, Teresa; Romao, Maria Joao; Leimkuehler, Silke. "Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms". Drug Metabolism and Disposition 44 8 (2016): 1277-1285. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000379415700017&KeyUID=WOS:000379415700017.
    10.1124/dmd.115.068395
  19. Bras, Joana L. A.; Pinheiro, Benedita A.; Cameron, Kate; Cuskin, Fiona; Viegas, Aldino; Najmudin, Shabir; Bule, Pedro; et al. "Diverse specificity of cellulosome attachment to the bacterial cell surface". Scientific Reports 6 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000389700700001&KeyUID=WOS:000389700700001.
    10.1038/srep38292
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  118. Dias, J.M.; Than, M.E.; Humm, A.; Huber, R.; Bourenkov, G.P.; Bartunik, H.D.; Bursakov, S.; et al. "Crystal structure of the first dissimilatory nitrate reductase at 1.9 Å solved by MAD methods". Structure 7 1 (1999): 65-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-0003123613&partnerID=MN8TOARS.
    10.1016/S0969-2126(99)80010-0
  119. Dias, J.M.; Bursakov, S.; Carneiro, C.; Moura, J.J.G.; Moura, I.; Romäo, M.J.. "Crystallization and preliminary X-ray analysis of a nitrate reductase from Desulfovibrio desulfuricans ATCC 27774". Acta Crystallographica Section D: Biological Crystallography 55 4 (1999): 877-879. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243397343&partnerID=MN8TOARS.
    10.1107/S0907444998014735
  120. Archer, M.; Carvalho, A.L.; Teixeira, S.; Moura, I.; Moura, J.J.G.; Rusnak, F.; Romão, M.J.. "Structural studies by X-ray diffraction on metal substituted desulforedoxin, a rubredoxin-type protein". Protein Science 8 7 (1999): 1536-1545. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032805156&partnerID=MN8TOARS.
    10.1110/ps.8.7.1536
  121. Glatigny, A.; Hof, P.; Romão, M.J.; Huber, R.; Scazzocchio, C.. "Altered specificity mutations define residues essential for substrate positioning in xanthine dehydrogenase". Journal of Molecular Biology 278 2 (1998): 431-438. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032079684&partnerID=MN8TOARS.
    10.1006/jmbi.1998.1707
  122. Voityuk, A.A.; Albert, K.; Romão, M.J.; Huber, R.; Rösch, N.. "Substrate Oxidation in the Active Site of Xanthine Oxidase and Related Enzymes. A Model Density Functional Study". Inorganic Chemistry 37 2 (1998): 176-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001136357&partnerID=MN8TOARS.
    10.1021/ic9707570
  123. Varela, P.F.; Romero, A.; Sanz, L.; Romão, M.J.; Töpfer-Petersen, E.; Calvete, J.J.. "The 2.4 Å resolution crystal structure of boar seminal plasma PSP-I/PSP-II: A zona pellucida-binding glycoprotein heterodimer of the spermadhesin family built by a CUB domain architecture". Journal of Molecular Biology 274 4 (1997): 635-649. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031565824&partnerID=MN8TOARS.
    10.1006/jmbi.1997.1424
  124. Romão, M.J.; Kölln, I.; Dias, J.M.; Carvalho, A.L.; Romero, A.; Varela, P.F.; Sanz, L.; Töpfer-Petersen, E.; Calvete, J.J.. "Crystal structure of acidic seminal fluid protein (aSFP) at 1.9 Å resolution: A bovine polypeptide of the spermadhesin family". Journal of Molecular Biology 274 4 (1997): 650-660. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031565993&partnerID=MN8TOARS.
    10.1006/jmbi.1997.1423
  125. Romão, M.J.; Rösch, N.; Huber, R.. "The molybdenum site in the xanthine oxidase-related aldehyde oxidoreductase from Desulfovibrio gigas and a catalytic mechanism for this class of enzymes". Journal of Biological Inorganic Chemistry 2 6 (1997): 782-785. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031446005&partnerID=MN8TOARS.
    10.1007/s007750050195
  126. Archer, M.; Banci, L.; Dikaya, E.; Romão, M.J.. "Crystal structure of cytochrome c' from Rhodocyclus gelatinosus and comparison with other cytochromes c'". Journal of Biological Inorganic Chemistry 2 5 (1997): 611-622. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030830925&partnerID=MN8TOARS.
    10.1007/s007750050176
  127. Romão, M.J.; Knäblein, J.; Huber, R.; Moura, J.J.G.. "Structure and function of molybdopterin containing enzymes". Progress in Biophysics and Molecular Biology 68 2-3 (1997): 121-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031554726&partnerID=MN8TOARS.
    10.1016/S0079-6107(97)00022-9
  128. Voityuk, A.A.; Albert, K.; Kostlmeier, S.; Nasluzov, V.A.; Neyman, K.M.; Hof, P.; Huber, R.; Romao, M.J.; Rosch, N.. "Prediction of alternative structures of the molybdenum site in the xanthine oxidase-related aldehyde oxido reductase". Journal of the American Chemical Society 119 13 (1997): 3159-3160. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030988323&partnerID=MN8TOARS.
    10.1021/ja963901+
  129. Romão, M.J.; Huber, R.. "Crystal structure and mechanism of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas". Biochemical Society Transactions 25 3 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-33745123701&partnerID=MN8TOARS.
  130. Adams, B.; Smith, A.T.; Doyle, W.A.; Bray, R.C.; Ryan, M.; Harrison, R.; Wolstenholme, A.J.; et al. "Expression of wild-type and mutated Drosophila melanogaster xanthine dehydrogenases in Aspergillus nidulans". Biochemical Society Transactions 25 3 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0030764385&partnerID=MN8TOARS.
  131. Romero, A.; Romao, M.J.; Varela, P.F.; Kölln, I.; Dias, J.M.; Carvalho, A.L.; Sanz, L.; Töpfer-Petersen, E.; Calvete, J.J.. "The crystal structures of two spermadhesins reveal the CUB domain fold". Nature Structural Biology 4 10 (1997): 783-788. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031255268&partnerID=MN8TOARS.
    10.1038/nsb1097-783
  132. Romão, M.J.; Huber, R.. "Crystal structure and mechanism of action of the xanthine oxidase-related aldehyde oxidoreductase from Desulfovibrio gigas". Biochemical Society Transactions 25 3 (1997): 755-757. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030761340&partnerID=MN8TOARS.
    10.1042/bst0250755
  133. Dias, J.M.; Carvalho, A.L.; Kölln, I.; Calvete, J.J.; Töpfer-Petersen, E.; Varela, P.F.; Romero, A.; Urbanke, C.; Romão, M.J.. "Crystallization and preliminary X-ray diffraction studies of aSFP, a bovine seminal plasma protein with a single CUB domain architecture". Protein Science 6 3 (1997): 725-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030896835&partnerID=MN8TOARS.
    10.1002/pro.5560060323
  134. Huber, R.; Hof, P.; Duarte, R.O.; Moura, J.J.G.; Moura, I.; Liu, M.-Y.; LeGall, J.; et al. "A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes". Proceedings of the National Academy of Sciences of the United States of America 93 17 (1996): 8846-8851. http://www.scopus.com/inward/record.url?eid=2-s2.0-9444219600&partnerID=MN8TOARS.
    10.1073/pnas.93.17.8846
  135. Zajc, A.; Romão, M.J.; Turk, B.; Huber, R.. "Crystallographic and fluorescence studies of ligand binding to N-carbamoylsarcosine amidohydrolase from Arthrobacter sp.". Journal of Molecular Biology 263 2 (1996): 269-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030601891&partnerID=MN8TOARS.
    10.1006/jmbi.1996.0574
  136. Kiefersauer, R.; Stetefeld, J.; Gomis-Rüth, F.X.; Romão, M.J.; Lottspeich, F.; Huber, R.. "Protein-Crystal Density by Volume Measurement and Amino-Acid Analysis". Journal of Applied Crystallography 29 PART 4 (1996): 311-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-0006403784&partnerID=MN8TOARS.
    10.1107/S0021889895014932
  137. Moura, J.J.G.; Goodfellow, B.J.; Romão, M.J.; Rusnak, F.; Moura, I.. "Analysis, design and engineering of simple iron-sulfur proteins: Tales from rubredoxin and desulforedoxin". Comments on Inorganic Chemistry 19 1 (1996): 47-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031287732&partnerID=MN8TOARS.
    10.1080/02603599608032727
  138. Goodfellow, B.J.; Tavares, P.; Romão, M.J.; Czaja, C.; Rusnak, F.; LeGall, J.; Moura, I.; Moura, J.J.G.. "The solution structure of desulforedoxin, a simple iron-sulfur protein: An NMR study of the zinc derivative". Journal of Biological Inorganic Chemistry 1 4 (1996): 341-354. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000053742&partnerID=MN8TOARS.
    10.1007/s007750050062
  139. Romero, A.; Caldeira, J.; Legall, J.; Moura, I.; Moura, J.J.G.; Romao, M.J.. "Crystal structure of flavodoxin from Desulfovibrio desulfuricans ATCC 27774 in two oxidation states". European Journal of Biochemistry 239 1 (1996): 190-196. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029953886&partnerID=MN8TOARS.
    10.1111/j.1432-1033.1996.0190u.x
  140. Frazao, C.; Dias, J.M.; Matias, P.M.; Romao, M.J.; Carrondo, M.A.; Hervas, M.; Navarro, J.A.; De La Rosa, M.; Sheldrick, G.M.. "Cytochrome c6 from the green alga Monoraphidium braunii. Crystallization and preliminary diffraction studies". Acta Crystallographica - Section D Biological Crystallography 51 2 (1995): 232-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029132455&partnerID=MN8TOARS.
    10.1107/S0907444994005184
  141. Archer, M.; Huber, R.; Tavares, P.; Moura, I.; Moura, J.J.G.; Carrondo, M.A.; Sieker, L.C.; LeGall, J.; Romao, M.J.. "Crystal structure of desulforedoxin from Desulfovibrio gigas determined at 1.8 Å resolution: A novel non-heme iron protein structure". Journal of Molecular Biology 251 5 (1995): 690-702. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029123025&partnerID=MN8TOARS.
    10.1006/jmbi.1995.0465
  142. Romão, M.J.; Archer, M.; Moura, I.; Moura, J.J.G.; LeGall, J.; Engh, R.; Schneider, M.; Hof, P.; Huber, R.. "Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas". Science 270 5239 (1995): 1170-1176. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028807552&partnerID=MN8TOARS.
  143. THOENES, U.; FLORES, O.L.; NEVES, A.; DEVREESE, B.; VAN BEEUMEN, J.J.; HUBER, R.; ROMÃO, M.J.; et al. "Molecular cloning and sequence analysis of the gene of the molybdenum-containing aldehyde oxido-reductase of Desulfovibrio gigas The deduced amino acid sequence shows similarity to xanthine dehydrogenase". European Journal of Biochemistry 220 3 (1994): 901-910. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028280650&partnerID=MN8TOARS.
    10.1111/j.1432-1033.1994.tb18693.x
  144. de C.T. Carrondo, M.A.A.F.; Morais, J.; Romão, C.C.; Romão, M.J.; Veiros, L.F.. "Cationic derivatives of niobocene(IV). Crystal structures of [Cp2NbL2][BF4]2 (L = CNMe, NCMe)". Polyhedron 12 7 (1993): 765-770. http://www.scopus.com/inward/record.url?eid=2-s2.0-0043010607&partnerID=MN8TOARS.
    10.1016/S0277-5387(00)81757-X
  145. ROMÃO, M.J.; BARATA, B.A.S.; ARCHER, M.; LOBECK, K.; MOURA, I.; CARRONDO, M.A.; LeGALL, J.; et al. "Subunit composition, crystallization and preliminary crystallographic studies of the Desulfovibrio gigas aldehyde oxidoreductase containing molybdenum and [2Fe-2S] centers". European Journal of Biochemistry 215 3 (1993): 729-732. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027217139&partnerID=MN8TOARS.
    10.1111/j.1432-1033.1993.tb18085.x
  146. Romão, M.J.; Turk, D.; Gomis-Rüth, F.-X.; Huber, R.; Schumacher, G.; Möllering, H.; Rüssmann, L.. "Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2·0 Å resolution". Journal of Molecular Biology 226 4 (1992): 1111-1130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026483887&partnerID=MN8TOARS.
    10.1016/0022-2836(92)91056-U
  147. Laber, B.; Gomis-Ruth, F.-X.; Romao, M.J.; Huber, R.. "Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization". Biochemical Journal 288 2 (1992): 691-695. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026486643&partnerID=MN8TOARS.
    10.1042/bj2880691
  148. Mynott, R.; Romão, M.J.; Herold, B.J.. "13C NMR study of substituted 10,10-diphenyl-9-phenanthrones. Structure determination and signal assignment using 2D NMR techniques". Magnetic Resonance in Chemistry 27 12 (1989): 1130-1133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989143773&partnerID=MN8TOARS.
    10.1002/mrc.1260271205
  149. Angermund, H.; Grevels, F.-W.; Moser, R.; Benn, R.; Krüger, C.; Romão, M.J.. "(¿2-trans-Cyclooctene)2Fe(CO)3 and related complexes: Structure and dynamic behavior". Organometallics 7 9 (1988): 1994-2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001534489&partnerID=MN8TOARS.
    10.1021/om00099a015
  150. Herold, B.J.; Romão, M.J.; Empis, J.M.A.; Evans, J.C.; Rowlands, C.C.. "The use of electron spin resonance and ENDOR and TRIPLE resonance methods for structural elucidation". Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases 83 1 (1987): 43-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049074188&partnerID=MN8TOARS.
    10.1039/F19878300043
  151. KRUGER, C; ROMAO, MJ. "STRUCTURE OF 6-FLUORO-10,10'-DIPHENYL-9-PHENANTHRONE (1), 7-CHLORO-10,10'-DIPHENYL-9-PHENANTHRONE (2) AND 3-METHOXY-10,10'-DIPHENYL-9-PHENANTHRONE (3)". Acta Crystallographica Section C-Crystal Structure Communications 42 (1986): 1404-1408.
    10.1107/S0108270186092107
  152. Benn, R.; Holle, S.; Jolly, P.W.; Krüger, C.; Romão, C.C.; Romão, M.J.; Rufinska, A.; Schroth, G.. "¿3-allyl complexes of molybdenum: reactions of [MoCl(¿3-C3H5)3] 2 and the crystal structure of [MoOAc(¿3-C3H5)3]". Polyhedron 5 1-2 (1986): 461-471. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000519387&partnerID=MN8TOARS.
    10.1016/S0277-5387(00)84950-5
  153. Frühauf, H.-W.; Sails, F.; Goddard, R.J.; Romão, M.J.. "1,5-Dihydropyrrol-2-ones from (1,4-Diaza-1,3-diene )tricarbonyliron and Alkyne. 2. Structure of a [2.2.2] Bicyclic Intermediate with Iron at the Bridgehead Position". Organometallics 4 5 (1985): 948-949. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000812375&partnerID=MN8TOARS.
    10.1021/om00124a031
  154. Brauer, D.J.; Hietkamp, S.; Sommer, H.; Stelzer, O.; Müller, G.; Romão, M.J.; Krüger, C.. "Lineare oligophosphaalkane XIII. Triphosphaalkane mit demPCPCP-donorskelett; liganden für den aufbau von mehrkernkomplexen". Journal of Organometallic Chemistry 296 3 (1985): 411-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-46549094714&partnerID=MN8TOARS.
    10.1016/0022-328X(85)80372-7
  155. A. Dohring; P. W. Jolly; C. Kruger; Maria João Romão. "THE NI(O)-CO2 SYSTEM - STRUCTURE AND REACTIONS OF [NI(PCY3)2(ETA-2-CO2)]". Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences 40 4 (1985): 484-488. https://novaresearch.unl.pt/en/publications/5a482b20-a899-4dbd-b89d-506350fc9d5e.
  156. HOBERG, H; FANANAS, FJ; ANGERMUND, K; KRUGER, C; ROMAO, MJ. "STRUCTURES AND PROPERTIES OF NEW CARBAMOYL-NICKEL COMPLEXES". Journal of Organometallic Chemistry 281 2-3 (1985): 379-388.
    10.1016/0022-328X(85)87123-0
  157. BARLUENGA, J; JOGLAR, J; FUSTERO, S; GOTOR, V; KRUGER, C; ROMAO, MJ. "PREPARATION AND REACTIVITY OF 2-AZA-1,3-BUTADIENES - A DIELS-ALDER ROUTE TO 5,6-DIHYDRO-2H-1,3-OXAZINE DERIVATIVES". Chemische Berichte-Recueil 118 9 (1985): 3652-3663.
    10.1002/cber.19851180919
  158. H. Hoberg; K. Radine; C. Kruger; Maria João Romão. "SYNTHESIS OF NEW PHOSPHINE NICKEL(I) COMPLEXES AND CRYSTAL-STRUCTURE OF MU-3-IODO-TRIS-MU-IODO-CYCLOTRIS(TRIPHENYLPHOSPHINE NICKEL), (TPP)3NI3I4". Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences 40 5 (1985): 607-614. https://novaresearch.unl.pt/en/publications/caa3ca3c-78e5-4481-95db-b31d7170d30b.
  159. K. R. Porschke; R. Mynott; C. Kruger; Maria João Romão. "TRIS(PHOSPHANE)-NICKEL(0)-ETHENE COMPLEXES (DMPE)(PR3)NI(C2H4) - MOLECULAR-STRUCTURE OF (DMPE)(P03)NI(C2H4)". Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences 39 8 (1984): 1076-1081. https://novaresearch.unl.pt/en/publications/b043eeb2-84d8-49ac-8db3-994fd2212f8f.
  160. HOBERG, H; SCHAEFER, D; BURKHART, G; KRUGER, C; ROMAO, MJ. "NICKEL(0)-INDUCED C-C COUPLING BETWEEN CARBON-DIOXIDE AND ALKYNES AS WELL AS ALKENES". Journal of Organometallic Chemistry 266 2 (1984): 203-224.
    10.1016/0022-328X(84)80129-1
  161. JOLLY, PW; KRUGER, C; ROMAO, CC; ROMAO, MJ. "ETA-3-ALLYL COMPLEXES OF MOLYBDENUM - THE PREPARATION AND STRUCTURE OF [MO(ETA-3-C3H5)2(ETA-5-C5H5)]". Organometallics 3 6 (1984): 936-937.
    10.1021/om00084a021
  162. Frühauf, H.-W.; Seils, F.; Romao, M.J.; Goddard, R.J.. "Zur Aktivität koordinierter 1,4-Diaza-1,3-diene (dad) bei C¿C-Verknüpfungsreaktionen: 3-Pyrrolin-2-one aus (dad)Fe(CO)3 und Dimethyl-acetylendicarboxylat". Angewandte Chemie International Edition in English 22 12 S (1983): 1435-1450. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912873347&partnerID=MN8TOARS.
    10.1002/anie.198314350
  163. FRUHAUF, HW; SEILS, F; ROMAO, MJ; GODDARD, RJ. "ACTIVITY OF COORDINATED 1,4-DIAZA-1,3-DIENES (DAD) IN C-C BOND FORMING REACTIONS - 1,5-DIHYDROPYRROL-2-ONES FROM (DAD)FE(CO)3 AND DIMETHYL ACETYLENEDICARBOXYLATE". Angewandte Chemie-International Edition in English 22 12 (1983): 992-993.
    10.1002/anie.198309921
Capítulo de livro
  1. Cristiano De Sousa Mota; Teresa Sacadura Santos-Silva; Mineko Terao; Enrico Garattini; Maria João Romão; Silke Leimkühler. "Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism". editado por Grunwald, {Peter. Routledge Taylor & Francis Group, 2019.
    10.1201/9780429295034-13
  2. Maria João Romão; Teresa Sacadura Santos-Silva; Ana Luísa Carvalho; Eurico J Cabrita; Filipa Margarida Barradas Morais Marcelo. "Structural elucidation of macromolecules". 30-91. Bentham Science Publishers Ltd., 2018.
    10.2174/97816810870921180101
  3. Carvalho, Ana Luísa; Trincão, José; Romão, Maria João; Carvalho, Ana Luisa; Trincao, Jose; Romao, Maria Joao; Roque, ACA. "X-Ray Crystallography in Drug Discovery". In Ligand-Macromolecular Interactions in Drug Discovery, 31-56. Humana Press, 2009.
    10.1007/978-1-60761-244-5_3
  4. Maria João Romão. "The role of molybdenum in biology". 507-510. JOHN LIBBEY EUROTEXT LTD, 2006.
  5. Romao, M.J.; Terao, M.. "Aldehyde Oxidoreductase (MOP)". In Handbook on Metalloproteins, 1037-1047. Wiley-VCH, 2001.
    Publicado • https://doi.org/10.1002/aoc.298
  6. Romão, Maria. "Dissimilatory Nitrate Reductase (NAP)". In Handbook on Metalloproteins, 1075-1085. CRC Press, 2001.
  7. Romão, Maria; Maria João Romão; Margarida Archer. "Cytochrome c´". In Handbook on Metalloproteins, editado por Albrecht Messerschmidt; Robert Huber; Thomas Poulas; Karl Wieghardt; Mirek Cygler; Wolfram Bode, 44-54. CRC Press, 2001.
    Publicado • 10.1002/0470028637.met103
Livro
  1. Brás, J.L.A.; Carvalho, A.L.; Viegas, A.; Najmudin, S.; Alves, V.D.; Prates, J.A.M.; Ferreira, L.M.A.; et al. Escherichia coli expression, purification, crystallization, and structure determination of bacterial cohesin-dockerin complexes. 2012.
    10.1016/B978-0-12-415931-0.00021-5
  2. Romão, M.J.; Archer, M.. Structural versatility of proteins containing rubredoxin-type centers. 2008.
    10.1002/9783527613700.ch20

Outros

Outra produção
  1. Raquel dos Santos; Iana Lychko; Maria João Romão; Roque, A.C.A.; Ana Luísa Carvalho. 2018. Magnetic crystallization proof-of-concept: Lysozyme and trypsin case study. https://novaresearch.unl.pt/en/publications/88281577-12cd-4b26-8c2c-b811d98f5054.
    10.1107/S2053273318092458
  2. Maria João Romão. 2018. Structural insights on aldehyde oxidase and xanthine oxidoreductase and their roles in xenobiotic metabolism. https://novaresearch.unl.pt/en/publications/54fbcf13-f39a-45c1-817d-8d70714d3e90.
    10.1016/j.freeradbiomed.2018.04.555
  3. Maria João Romão. 2018. The crystal structure of human aldehyde oxidase. https://novaresearch.unl.pt/en/publications/e2b85ca0-927b-4349-83b6-97a123ae0b95.
  4. Gomes, Ana Sara; Trovão, Filipa; Andrade Pinheiro, Benedita; Freire, Filipe; Gomes, Sara; Oliveira, Carla; Domingues, Lucília; et al. 2018. The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding. The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as a molecular hub regulating different cell responses, namely cell death. Compelling data have demonstrated that the impairment of p53 activity correlates with tumor development and maintenance. For these reasons, the reactivation of p53 function is regarded as a promising strategy to halt cancer. In. http://hdl.handle.net/1822/54422.
    10.3390/ijms19041184
  5. Leisico, Francisco; Vieira, Diana V.; Figueiredo, Teresa A.; Silva, Micael; Cabrita, Eurico J.; Sobral, Rita G.; Ludovice, Ana Madalena; et al. 2018. First insights of peptidoglycan amidation in Gram-positive bacteria-The high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD. Gram-positive bacteria homeostasis and antibiotic resistance mechanisms are dependent on the intricate architecture of the cell wall, where amidated peptidoglycan plays an important role. The amidation reaction is carried out by the bi-enzymatic complex MurT-GatD, for which biochemical and structural information is very scarce. In this work, we report the first crystal structure of the glutamine a. http://www.scopus.com/inward/record.url?scp=85044530342&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-018-22986-3
  6. Viviana G. Correia; Joana L. A. Bras; Yan Liu; Lisete Silva; Yibing Zhang; Benedita Pinheiro; Maria João Romão; et al. 2016. An integrative strategy to decipher glycan recognition in the human gut microbiome. https://novaresearch.unl.pt/en/publications/56c19fd5-923c-4d8b-b240-3ea4dc282361.
  7. Brás, Joana L. A.; Pinheiro, Benedita A; Cameron, Kate; Cuskin, Fiona; Viegas, Aldino; Najmudin, Shabir; Bule, Pedro; et al. 2016. Diverse specificity of cellulosome attachment to the bacterial cell surface. During the course of evolution, the cellulosome, one of Nature's most intricate multi-enzyme complexes, has been continuously fine-tuned to efficiently deconstruct recalcitrant carbohydrates. To facilitate the uptake of released sugars, anaerobic bacteria use highly ordered protein-protein interactions to recruit these nanomachines to the cell surface. Dockerin modules located within a non-catalyt. http://hdl.handle.net/10362/36982.
    https://doi.org/10.1038/srep38292
  8. Ana Luísa Carvalho; Maria João Romão. 2013. The Structural Basis of the Recognition of Di-glucosylated N-glycans by the ER Lectin Malectin. https://novaresearch.unl.pt/en/publications/a3f0fd44-8cef-4765-a321-f549d44a6fa4.
  9. Maria João Romão. 2013. Unraveling new functions and modes of action of molybdenum-dependent enzymes. https://novaresearch.unl.pt/en/publications/cd76c58a-66e3-4859-92e2-ed7151dc02a6.
  10. Teresa Sacadura Santos-silva; Maria João Romão. 2013. Vanadium compounds as prospective therapeutics: X-ray structure of protein adducts. https://novaresearch.unl.pt/en/publications/1c00769b-51ef-4386-8dc6-b2766ff916cd.
  11. Ana Luísa Carvalho; Maria João Romão. 2013. Determinants of selective group reduction in the TNT-bound xenobiotic reductase B from P. putida. https://novaresearch.unl.pt/en/publications/02c08dc6-e8b3-4559-9df0-dce85ceb47f3.
  12. Marangon, Jacopo; Correia, Hugo D.; Brondino, Carlos D.; Moura, José João Galhardas de; Romão, Maria João; Gonzalez, Pablo Javier; Santos-silva, Teresa Sacadura; CQFB-REQUIMTE - Centro de Química Fina e Biotecnologia (Lab. Associado REQUIMTE); DQ - Departamento de Química. 2013. Kinetic and Structural Studies of Aldehyde Oxidoreductase from Desulfovibrio gigas Reveal a Dithiolene-Based Chemistry for Enzyme Activation and Inhibition by H2O2.. Mononuclear Mo-containing enzymes of the xanthine oxidase (XO) family catalyze the oxidative hydroxylation of aldehydes and heterocyclic compounds. The molybdenum active site shows a distorted square-pyramidal geometry in which two ligands, a hydroxyl/water molecule (the catalytic labile site) and a sulfido ligand, have been shown to be essential for catalysis. The XO family member aldehyde oxidor. http://hdl.handle.net/10362/21666.
    https://doi.org/10.1371/journal.pone.0083234
  13. Anjos L. Macedo; Ana Luísa Carvalho; Maria João Romão. 2012. Structural studies of the p22HBP/SOUL family of heme-binding proteins. https://novaresearch.unl.pt/en/publications/9a682d63-db87-46a4-b9e8-43e1644e1abb.
  14. Ana Luísa Carvalho; Anjos L. Macedo; Maria João Romão. 2009. Structural and dynamic characterization of hSOUL, a heme-binding protein. https://novaresearch.unl.pt/en/publications/37efe703-e361-41bd-8dab-d0d8ee05a4d5.
  15. Gavel, Olga Yu.; Kladova, Anna V.; Bursakov, Sergey A.; Dias, João M.; Texeira, Susana; Moura, José J. G.; Moura, Isabel; Romão, Maria J.; Trincão, José. 2008. Purification, crystallization and preliminary X-ray diffraction analysis of adenosine triphosphate sulfurylase (ATPS) from the sulfate-reducing bacterium Desulfovibrio desulfuricans ATCC 27774. Native zinc/cobalt-containing ATP sulfurylase (ATPS; EC 2.7.7.4; MgATP: sulfate adenylyltransferase) from Desulfovibrio desulfuricans ATCC 27774 was purified to homogeneity and crystallized. The orthorhombic crystals diffracted to beyond 2.5 A ° resolution and the X-ray data collected should allow the determination of the structure of the zinc-bound form of this ATPS. Although previous biochemical. http://hdl.handle.net/10362/7027.
  16. F. V. Ventura; S. Violante; C. Gomes; Ana Luísa Carvalho; Maria João Romão; M. M. Gaspar; M. E. M. Cruz; et al. 2007. The human carnitine acylcarnitine translocase (hCACT): Strategies for its heterologous expression, purification and crystallization. https://novaresearch.unl.pt/en/publications/fe3909e5-9fbe-4571-8ae9-cebe17bdfe53.
  17. Shabir Najmudin; Ana Luísa Carvalho; Maria João Romão; Catarina I. P. D. Guerreiro; José A. M. Prates; Márcia A. S. Correia; Vitor Alves; et al. 2006. Structure and function of PKD-CBM44 and CBM30 modules of the bifunctionalClostridium thermocellumcellulase, CtCel9D-Cel44A. https://novaresearch.unl.pt/en/publications/10d48655-f5a8-4263-96a1-2cd568899964.
    10.1107/s0108767306097224
  18. I. Moura; I. Cabrito; G. Almeida; C. Cunha; Maria João Romão; José J. G. Moura. 2003. Molecular aspects of denitrification/nitrate dissimilation. https://novaresearch.unl.pt/en/publications/3f5474db-89f9-4814-adf2-4c085a0912e6.
    10.1016/S0162-0134(03)80717-1
  19. Moura, Isabel; Cunha, Carlos A.; Macieira, Sofia; Dias, João M.; Almeida, Gabriela Machado de; Gonçalves, Luisa L.; Costa, Cristina; et al. 2003. Cytochrome c nitrite reductase from desulfovibrio desulfuricans ATCC 27774. The gene encoding cytochrome c nitrite reductase(NrfA) from Desulfovibrio desulfuricans ATCC 27774 was sequenced and the crystal structure of the enzyme was determined to 2.3-Å resolution. In comparison with homologous structures, it presents structural differences mainly located at the regions surrounding the putative substrate inlet and product outlet, and includes a well defined second calcium. http://hdl.handle.net/10362/1658.
  20. L. M. L. Gonçalves; C. Cunha; G. Almeida; S Macieira; Cristina Costa; J. Lampreia; Maria João Romão; José J. G. Moura; I. Moura. 2001. Structural studies on Desulfovibrio desulfuricans ATCC 27774 multiheme nitrite reductase - characterization of the subunits. https://novaresearch.unl.pt/en/publications/d3ba956e-f04e-4e0e-b3a9-743e74e55eef.
  21. S. Teixeira; Joao ML Dias; Ana Luísa Carvalho; G. Bourenkov; H. Bartunik; M. J. Almendra; I. Moura; José J. G. Moura; Maria João Romão. 1999. Crystallographic studies on a tungsten-containning formate dehydrogenase from Desulfovibrio gigas. https://novaresearch.unl.pt/en/publications/f74c8bb6-8e34-487f-9cb5-290adf5ff4f3.
  22. S. A. Bursakov; C. Brondino; J. M. Dias; C. Carneiro; J. Caldeira; R. O. Duarte; Maria João Romão; I. Moura; José J. G. Moura. 1999. Cross immunological reactions and spectroscopy study within nitrate reductase and other mononuclear Mo containing enzymes of the sulfate reducing bacteria. https://novaresearch.unl.pt/en/publications/83190245-7b86-40d1-bc04-216d0efa9bb2.
  23. Maria João Romão; Ana Luísa Carvalho; J. M. Dias; S. Teixeira; G. Bourenkov; H. Bartunik; R. Huber; Luisa Maia; L. Mira. 1999. Preliminary crystallographic studies of xanthine oxidase purified from rat liver. https://novaresearch.unl.pt/en/publications/02d2e607-791a-4d09-bbdf-cfb00aeb5ec5.
  24. J. M. Dias; M. E. Than; R. Huber; G. P. Bourenkov; H. D. Bartunik; S. Bursakov; José J. G. Moura; I. Moura; Maria João Romão. 1999. Crystallographic studies of a dissimilatory nitrate reductase and mechanistic implications. https://novaresearch.unl.pt/en/publications/87b02097-81ad-4b2c-8c24-452d81a9f67b.
  25. A. Romero; P. F. Varela; Maria João Romão; L. Sanz; E. TopferPetersen; J. J. Calvete. 1997. The three-dimensional structure of mammalian spermadhesins determined by x-ray crystallography. https://novaresearch.unl.pt/en/publications/a1d0430a-e126-4db0-a46e-df9e73e7abd0.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019 Mo/W-dependent Formate Dehydrogenases and the reversible interconversion of CO2 and formate (PLENARY) 2019- International Conference on Hydrogenases
(Lisboa, Portugal)
2019 What crystallography can still reveal about two families of Mo and W enzymes 11th MOLYBDENUM & TUNGSTEN ENZYME CONFERENCE- MOTEC
(Potsdam, Alemanha)
2018 Structural insights on Aldehyde Oxidase and Xanthine Oxidoreductase and their roles in xenobiotic metabolism 19th SFRRI Biennial Meeting, Lisbon, 4-7 June 2018
(Lisboa, Portugal)
2017 Structure and function of mammalian Aldehyde Oxidases and their role in the metabolism of drugs and xenobiotics 14th ISABC
(Toulouse, França)
2017 Mammalian Aldehyde Oxidases and their impact in xenobiotics metabolism and drug development, Santa Fe, New Mexico, USA, June 18-23 2017 10th MOTEC- Mo and W Enzyme Conference
( Santa Fe, New Mexico, Estados Unidos)
2017 The Crystal Structure of human Aldehyde Oxidase 21st North American ISSX Meeting, Providence, Rhode Island
(Providence, Rhode Island, Estados Unidos)
2016 Molybdenum enzymes in Drug Metabolism and Biotransformations , 2016- ICCC2016
(Brest, França)
2015 “Aldehyde Oxidases in Drug Metabolism and Biotransformations”. (PLENARY) 9th MOTEC - Molybdenum and Tungsten Molybdenum Conference,
(Balatonfüred, Hungria)
2014 “Molybdenum Enzymes in Health and Disease” 2014 - FrenchBIC Meeting
(Anglet, França)
2013 “Unraveling new functions and modes of action of molybdenum-dependent enzymes” (PLENARY) 2013 - 9th European Biophysics Congress EBSA2013,
(Lisboa, Portugal)
2011 The Crystal Structure of Mouse Aldehyde Oxidase Homologue 1 and Insights into Substrate Specificity MOTEC - MOLYBDENUM AND TUNGSTEN ENZYME MEETING , Alberta, Canada, August 2011,
(Alberta, Canadá)
2007 “Molecular and cellular biology of Mo and W" (5th GRC Mo&W enzymes) 5th GORDON Research Conference on “Molybdenum & Tungsten Enzymes”, New-London, NH, USA, July, 2007
(New-London, NH, Estados Unidos)
2006 "The Role of Molybdenum in Biology" 9th International Symposia on Metal Ions in Biology and Medicine
(Lisboa, Portugal)
2005 Penta-heme Nitrite Reductase and di-heme Cytochrome c Peroxidase International Conference in Bioinorganic Chemistry ICBIC
(Ann Arbor, Estados Unidos)
2005 Structural Studies on Formate Dehydrogenases (4th GRC on Mo&W enzymes) 4th GORDON Research Conference on “Molybdenum and tungsten Enzymes”,
(Oxford, Reino Unido)
2004 “Structural Studies in active and inactive forms of di-heme cytochrome c peroxidases from Pseudomonas nautica and Pseudomonas stutzeri” 36th International Congress in Coordination Chemistry
(Merida, México)
2003 A Crystallographic Perspective of Molybdenum in Biology (PLENARY) FIGIPS 2003
(Lisboa, Portugal)
2002 How crystallography contributed to the understanding of Mo and W enzymes Alumni Meeting in honor to Robert Huber
(Ringberg, Alemanha)
2002 W-FORMATE DEHYDROGENASE And NITRATE REDUCTASE From SULFATE REDUCERS: Structures and Functions from Enzymes of the Same Family EUROBIC-6, Lund Copenhagen
(Copenhagen, Dinamarca)
2002 Molybdopterin-Dependent Enzymes And The Role Of The Catalytic Mo (or W) Active Site (PLENARY) SFB Congress- Metal Mediated Reactions Modelled after Nature
(Jena, Alemanha)
2001 “Formate Dehydrogenase From Desulfovibrio gigas : A Tungsten Enzyme Containing Se And 4x[4F-4S] Centers” (2nd GRC on Mo&W enzymes) 2nd GORDON Research Conference on Mo and W proteins
GRC (Oxford, Reino Unido)
2001 Crystallographic Studies And Mechanistic Implications On Mo And W Enzymes 20th European Crystallographic Meeting
(Krakow, Polónia)
1999 Structural Studies on Molybdopterin containing Enzymes Invited guest to the Institut für Biochemie, Universidade de Medicina de Lübeck
Institut für Biochemie, Universidade de Medicina de Lübeck, Germany (Lübeck, Alemanha)
1999 “The first crystal structure of a dissimilatory Nitrate Reductase and implications on the reactions mechanism” (1st GRC on Mo&W enzymes) 1st GORDON Research Conference on Molybdenum and Tungsten Enzymes
GRC (Plymouth, New Hampshire, Estados Unidos)
1998 Structure and Functional Aspects of Molybdopterin containing enzymes TMR Summer School I and II
Instituto de Tecnologia Quimica e Biologica (Oeiras, Portugal)
1998 Crystallography of Mo-Hydroxylases European Xanthine Oxidase Workshop
(Roterdam, Países Baixos)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019 - Atual Biosynthesis and a characterizations of an antibody fragment against STEAPI as a vehicle for cancer therapy
Coorientador de Ana Margarida Grilo Gonçalves
Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2016 - Atual Peptidoglycan amidation in Gram-positive bacteria and structural studies in the Staphylococcus aureus enzymes
Coorientador de Francisco Leisico
Biomolecular Sciences (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2017 Structural studies on molybdenum-dependent enzymes: from transporters to enzymes
Coorientador de Ana Rita Castro Otrelo Cardoso
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2016 Structural and Functional studies on the Reactivity of CORMs with plasma proteins
Coorientador de Marino Filipe Alves dos Santos
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2014 Crystallographic studies of proteins involved in the mRNA Localization Mechanisms in Drosophila melanogaster and Amidation of the Peptidoglycan Residues in Staphylococcus aureus
Coorientador de Diana Maria Patacas Viegas Vieira
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2009 - 2012 Integrated study by NMR and X-ray Crystallography on the analysis of the molecular interactions in heme-binding proteins
Coorientador de Filipe Miguel dos Santos Freire
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2011 Crystallographic Studies on Molybdopterin — dependent Enzymes
Orientador de Catarina Maria Campos Coelho
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2002 - 2006 Metabolismo do Metilglioxal em Tripanossomatídeos
Coorientador de Lídia Isabel Sebastião Barata
Bioquímica
Universidade de Lisboa, Portugal
2002 - 2006 Structural Characterization of Heme and Non-heme Iron Containing Proteins
Orientador de Teresa Sacadura Santos Silva
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2000 - 2004 Biosynthesis and Function of Biological Pteridines. Structural Studies on Two Molybdopterin Containing Aldehyde Oxido-reductases, from Desulfovibrio Desulfuricans Atcc 27774 and from Desulfovibrio Gigas, and the Gtp Cyclohydrolase I on E. Coli, Responsibl
Coorientador de Jorge Manuel Baeta Simões Rebelo
Biochemistry (Doutoramento)
Universidade Nova de Lisboa, Portugal
1999 - 2002 Structure & Function of Nitrate Reductase and Di-haem Cytochrome C Peroxidase
Orientador de João Miguel Carrapa Nunes Dias
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1998 - 2002 Caracterização Estrutural de Proteínas Envolvidas em Processos de Reprodução Animal
Orientador de Ana Luísa Moreira de Carvalho
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1998 - 2002 Modelação Molecular e Caracterização Estrutural de Quimeras de Proteínas de Transferência Electrónica
Coorientador de Carlos Manuel Alves da Costa Cunha
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1993 - 1997 Crystal Structure Analysis of Metalloproteins: Cytochrome C´ and Desulforedoxin (native and Metal Reconstituted)
Orientador de Margarida Archer Baltazar Pereira Silva Franco Frazão
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2011 - Atual 9TH CARBOHYDRATE BIOENGINEERING MEETING CBM9, May 2011, Lisbon (2011)
Conferência (Membro da Comissão Organizadora)
2006 - Atual EUROBIC 2006 8th EUROPEAN BIOLOGICAL CHEMISTRY CONFERENCE, Aveiro (Organizing Committee) (>500 participants). (2006)
Congresso (Membro da Comissão Organizadora)
2006 - Atual 6th IBERO-AMERICAN CONGRESS OF BIOPHYSICS (2006)
Congresso (Membro da Comissão Científica)
1998 - Atual SUMMER SCHOOL I “STRUCTURE AND FUNCTION OF METALLOPROTEINS”, ITQB, Oeiras (Organizing Committee) (ca. 80 participants). (1997)
Oficina (workshop) (Membro da Comissão Organizadora)
1997 - Atual ECM 17 -EUROPEAN CRYSTALLOGRAPHIC MEETING (>900 participants). IST, Lisboa (Organizing Committee) (1997)
Congresso (Membro da Comissão Organizadora)

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2018 “Purification and Characterization of Mouse Aldehyde Oxidases”
Vogal
Gokhan Kucukgoze (Doutoramento)
Universität Potsdam Institut für Biochemie und Biologie, Alemanha
2013 “Die Funktion und Spezifität der Molybdän-Cofaktor-bindenden Chaperone für die Formiat-Dehydrogenasen aus Escherichia coli und Rhodobacter capsulatus”
Vogal
By Nadine Schwanhold (born Böhmer) (Doutoramento)
Universität Potsdam Institut für Biochemie und Biologie, Alemanha
2012 Biosynthesis isolation and kinetic characterization of recombinant human catechol-O-methyltransferase from pichia pastoris strains
Arguente principal
Augusto Quaresma Henriques Pedro (Doutoramento)
Universidade da Beira Interior, Portugal
2009 New Insights Into the Structure and Function of Human Phenylalanine Hidroxylase: Interallelic Complementation Protein Misfolding and Mechanism of Catalytic Activation
Arguente principal
João Paulo Travassos Leandro (Doutoramento)
Universidade de Lisboa, Portugal
2005 Structural and Functional Insights Into the Role of Carbohydrate Esterases and Carbohydrate-binding Modules in Plant Cell Wall Hydrolysis
Arguente principal
Márcia Alexandra da Silva Correia (Doutoramento)
2003 X-ray Structure Determination of Iron-containing Proteins from Desulfovibrio Desulfuricans Atcc 27774 in Different Redox States: Bacterioferritin and Hybrid Cluster Protein
Arguente principal
Sofia Isabel Vaz Queiroz de Macedo (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2002 Proteínas Contendo Molibdénio e Tungsténio
Arguente principal
Rui Manuel de Oliveira Duarte (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2000 Nmr Solution Structure of Cytochromes C3: Insight Into the Structural Origins of Functional Cooperativities (main Arguer)
Arguente principal
Ana Cristina Messias Coelho (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1996 Cristalização e Análise Estrutural por Difracção de Raios X de Metaloproteínas Bacterianas
Arguente principal
José António Morais Antunes (Doutoramento)

Arbitragem científica em conferência

Nome da conferência Local da conferência
2018 - Atual ECM 31, European Crystallographic Meeting , Oviedo Spain (Session Chair)
2010 - Atual IV SPANISH-PORTUGUESE BIOPHYSICAL CONGRESS (Session Chair)
2009 - Atual 6th GORDON RESEARCH CONFERENCE on “Molybdenum & Tungsten Enzymes”, (Chair) GRC Conferences

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2019 - Atual Member of FWO (Fonds Wetenschappelijk Onderzoek – Vlaanderen). expert panel
Avaliador
Fonds Wetenschappelijk Onderzoek Vlaanderen, Bélgica Fonds Wetenschappelijk Onderzoek Vlaanderen
2018 - Atual EVALUATION OF SEVERO OCHOA Severo Ochoa Centres of Excellence and María de Maeztu Units of Excellence
Avaliador
Severo Ochoa Centres of Excellence and María de Maeztu Units of Excellence
2016 - Atual Member of the European Science Foundation (ESF) College of Expert Reviewers
Avaliador
European Science Foundation
2009 - Atual Evaluator of research units and research projects by invitation of the German Science Foundation (DFG)
Avaliador
Deutsche Forschungsgemeinschaft
Distinções

Prémio

1995 Prize - "Oeiras, A Ciência e o Desenvolvimento"
Camara Municipal de Oeiras, Portugal

Fundacao Marques de Pombal, Portugal
1993 "Crystal Award" - Crystallization prize for the first molybdopterin enzyme
Max-Planck-Institut für Biochemie Proteomics und Signaltransduktion, Alemanha
1978 Hylleraas Prize
Uppsala Universitet Institutionen för biokemi och organisk kemi, Suécia

Outra distinção

2019 Member of the Scientific Advisory Committee of the Spanish Synchrotron ALBA (Portuguese Observer )
Fundação para a Ciência e a Tecnologia, Portugal
2019 Member of the Evaluation Panel (BIO1RP) from the Research Foundation from Flanders (FWO)
2017 Co-Editor, Acta Crystallographica Section F
International Union of Crystallography, Reino Unido
2016 “100 Mulheres na Ciência” (100 Women in Science )
Pavilion of Knowledge, Portugal
2012 Portuguese Observer to the Council of the European Synchrotron Radiation Facility (ERSF), Grenoble
Fundação para a Ciência e a Tecnologia, Portugal
2010 Executive Committee of the European Synchrotron User Organization (ESUO)
2006 Member of the Editorial Advisory Board of the Journal of Biological Inorganic Chemistry
Society of Biological Inorganic Chemistry, Itália