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Rosa Direito. finished her PhD in Pharmacy (specialty Food Science) on 2019/07/09 through the Faculty of Pharmacy of the University of Lisbon, has a Masters in Biochemistry attained in 2009 by the Faculty of Sciences and Technology of the University of Coimbra and a Bachelors degree in Biochemistry attained in 2005 from this same university. She collaborates with the University of Lisbon's Research Institute for Medicines (iMed.ULisboa) and is the acting Scientific Director for Prime Matter Consulting, Lda, a multidisciplinary consulting firm dedicated to political, management and scientific consulting. She has her name published in 15 articles published in peer-reviewed scientific journals, including 1 book chapter. She has received 1 prize/grant attributed by the Dean of the University of Lisbon. She acts in the área of Natural Sciences with emphasis on Biological Sciences, more specifically on Biochemistry, and in Medical and Health Sciences, with an emphasis on Nutrition and Dietetics. Thus far she has interacted with at least 98 colleagues in co-authorship of scientific work. In her curriculum vitae, the most frequent terms used are: spearmint; Mentha spicata L.; phenolics; inflammation; colitis; colorectal cancer; phenolic compounds; persimmon; inflammatory bowel disease; noncommunicable diseases; Food Science; Pharmacy; Biochemistry; Animal Models; Persimmon; Diospyros kaki L.; Food Toxicology; Quality Control; Clinical Nutrition; Evaluator; Fellowship; Grant; Research Excellence; Rapporteur; antioxidants; Biology; Reviewer; Biomolecules.
Identificação

Identificação pessoal

Nome completo
Rosa Direito

Nomes de citação

  • Direito, Rosa
  • Direito R

Identificadores de autor

Ciência ID
2712-11CA-AFFC
ORCID iD
0000-0002-4143-4302
Google Scholar ID
V6k_YC0AAAAJ&hl
Researcher Id
S-4473-2019
Scopus Author Id
56429567800

Endereços de correio eletrónico

  • rdireito@ff.ulisboa.pt (Profissional)
  • RDireito@ihmt.unl.pt (Profissional)

Moradas

  • Faculty of Pharmacy - Universidade de Lisboa - Av. Professor Gama Pinto, 1649-003, Lisbon, Lisbon, Portugal (Profissional)
  • Institute of Hygiene and Tropical Medicine (IHMT), Rua da Junqueira, 100, 1349-008, Lisbon, Lisbon, Portugal (Profissional)

Websites

  • https://www.researchgate.net/profile/Rosa_Direito (Rede social)
  • https://www.primematterconsulting.com/ (Profissional)

Domínios de atuação

  • Ciências Naturais
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Ciências da Saúde - Nutrição e Dietética
  • Ciências Naturais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1)
Português (Idioma materno)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2015/05/01 - 2019/07/09
Concluído
Pharmacy (Doutoramento)
Especialização em Specialty: Food Science (Bromatology)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Avaliação do Papel do Extracto Dióspyros Kaki L. na prevenção de inflamação e cancro (translated title): “Evaluation of the role of Diospyros kaki L. (Persimmon) extract in the prevention of inflammation and cancer.”" (TESE/DISSERTAÇÃO)
Distinction and Praise
2007 - 2009
Concluído
Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Morphological evaluation of rat liver tissue after the subcutaneous injection of 1,2-dimethylhydrazine" (TESE/DISSERTAÇÃO)
16
2000 - 2005
Concluído
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"na" (TESE/DISSERTAÇÃO)
13
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2021/07 - Atual Pós-doutorado (Investigação) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012/06/01 - Atual Investigador (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/01/01 - 2020/06/30 Pós-doutorado (Investigação) Instituto Gulbenkian de Ciência, Portugal
2004/09 - 2005/07 Estagiário de Investigação (Investigação) Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Outras Carreiras

Categoria Profissional
Instituição de acolhimento
Empregador
2020/07 - Atual Carreiras / Categorias Subsistentes Prime Matter Consulting, Lda, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2007 - 2009 Mestrado Universidade de Coimbra Faculdade de Medicina, Portugal
Instituto de Patologia Experimental, Portugal
Projetos

Bolsa

Designação Financiadores
2015 - 2019/04/30 Avaliação do papel do extrato de Diospyros Kaki L. (dióspiro) na prevenção da inflamação e cancro
REITORIA/BD/FF01/2015
Bolseiro de Doutoramento
Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa
Concluído

Projeto

Designação Financiadores
2021 - 2024/03/14 Immune precision medicine as a new opportunity to control canine trypanosomatid diseases - DogIPM
PTDC/CVT-CVT/0228/2020
Bolseiro de Pós-Doutoramento
Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020 - 2020/06/30 Macrophages and sympathetic neurons in obesity
LISBOA-01-0145-FEDER-030892
Investigador Pós-doutorado
Instituto Gulbenkian de Ciência, Portugal
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Produções

Publicações

Artigo em revista
  1. Joana Mota; Rosa Direito; João Rocha; João Fernandes; Bruno Sepodes; Maria Eduardo Figueira; Anabela Raymundo; Ana Lima; Ricardo Boavida Ferreira. "Lupinus albus Protein Components Inhibit MMP-2 and MMP-9 Gelatinolytic Activity In Vitro and In Vivo". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222413286.
    10.3390/ijms222413286
  2. Joao Rocha; Bruno Sepodes; Figueira, ME. "From Diospyros kaki L. (Persimmon) Phytochemical Profile and Health Impact to New Product Perspectives and Waste Valorization". Nutrients (2021): https://www.mdpi.com/2072-6643/13/9/3283.
    10.3390/nu13093283
  3. Rosa Direito; João Rocha; Bruno Sepodes; Maria Eduardo-Figueira. "Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation". Pharmaceutics 13 2 (2021): 145-145. https://doi.org/10.3390/pharmaceutics13020145.
    10.3390/pharmaceutics13020145
  4. João Rocha; Raquel Leandro; Rosa Direito; Margarida Gonçalves; Maria Paula Duarte; Adelaide Fernandes; Bruno Sepodes; Maria-Eduardo Figueira. "Attenuation of Colonic Injury and Inflammation by Administration of a Phenolic Extract of Summer Savory (Satureja hortensis L.) in Experimental Inflammatory Bowel Disease in Mice". Applied Sciences 10 23 (2020): 8465-8465. https://doi.org/10.3390/app10238465.
    10.3390/app10238465
  5. Rosa Direito; João Rocha; Ana-Teresa Serra; Adelaide Fernandes; Marisa Freitas; Eduarda Fernandes; Rui Pinto; et al. "Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis". Journal of Dietary Supplements (2019): https://doi.org/10.1080/19390211.2019.1645256.
    10.1080/19390211.2019.1645256
  6. Rosa Direito; Catarina Reis; Luís Roque; Margarida Gonçalves; Ana Sanches-Silva; Maria Manuela Gaspar; Rui Pinto; et al. "Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability". Pharmaceutics (2019): https://doi.org/10.3390/pharmaceutics11060296.
    10.3390/pharmaceutics11060296
  7. Direito, Rosa; Rocha, João; Lima, Ana; Gonçalves, Maria Margarida; Duarte, Maria Paula; Mateus, Vanessa; Sousa, Catarina; et al. "Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice". Medicines 6 2 (2019): 65. http://dx.doi.org/10.3390/medicines6020065.
    10.3390/medicines6020065
  8. Mota, A.H.; Direito, R.; Carrasco, M.P.; Rijo, P.; Ascensão, L.; Viana, A.S.; Rocha, J.; et al. "Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis". International Journal of Pharmaceutics 559 (2019): 13-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060554783&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2019.01.017
  9. Rocha, J.; Direito, R.; Lima, A.; Mota, J.; Gonçalves, M.; Duarte, M.P.; Solas, J.; et al. "Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice". Biomedicine and Pharmacotherapy 118 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070874907&partnerID=MN8TOARS.
    10.1016/j.biopha.2019.109351
  10. Mendes, C.; Rocha, J.; Direito, R.; Fernandes, A.; Sepodes, B.; Figueira, M.-E.; Ribeiro, M.H.. "Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices". Journal of Functional Foods 63 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072299230&partnerID=MN8TOARS.
    10.1016/j.jff.2019.103564
  11. Vieira da Silva, S.A.; Clemente, A.; Rocha, J.; Direito, R.; Marques, H.C.; Sepodes, B.; Figueira, M.-E.; Ribeiro, M.H.. "Anti-inflammatory effect of limonin from cyclodextrin (un)processed orange juices in in vivo acute inflammation and chronic rheumatoid arthritis models". Journal of Functional Foods 49 (2018): 146-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051776212&partnerID=MN8TOARS.
    10.1016/j.jff.2018.08.024
  12. Direito R; Lima A; Rocha J; Ferreira RB; Mota J; Rebelo P; Fernandes A; et al. "Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.". The Journal of nutritional biochemistry (2017): http://europepmc.org/abstract/med/28494341.
    10.1016/j.jnutbio.2017.03.002
  13. Maria-Eduardo Figueira; Mónica Oliveira; Rosa Direito; João Rocha; Paula Alves; Ana-Teresa Serra; Catarina Duarte; et al. "Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat". Biomedicine & Pharmacotherapy 83 (2016): 1191-1202. https://doi.org/10.1016%2Fj.biopha.2016.08.040.
    10.1016/j.biopha.2016.08.040
  14. Silva S; Sepodes B; Rocha J; Direito R; Fernandes A; Brites D; Freitas M; et al. "Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis.". (2015): http://europepmc.org/abstract/med/25620693.
    10.1016/j.jnutbio.2014.11.011
  15. Figueira ME; Câmara MB; Direito R; Rocha J; Serra AT; Duarte CM; Fernandes A; et al. "Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis.". (2014): http://europepmc.org/abstract/med/25322288.
    10.1039/c4fo00376d
  16. Rocha, J.; Barateiro, A.; Fernandes, A.; Raposo, J.; Direito, R.; Eduardo-Figueira, M.; Pinto, R.; et al. "GLYCOGEN SYNTHASE KINASE-3 INHIBITION REDUCES LIVER, NEUROMUSCULAR, AND LUNG INJURY CAUSED BY BURN INJURY IN THE RAT". Shock (2013): https://publons.com/publon/4010045/.
  17. Alves G; Fortuna A; Sousa J; Direito R; Almeida A; Rocha M; Falcão A; Soares-da-Silva P. "Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine and its metabolites.". (2010): http://europepmc.org/abstract/med/20592643.
    10.1097/FTD.0b013e3181e5c855
Capítulo de livro
  1. Direito, Rosa. "CARACTERIZAÇÃO QUÍMICA E AVALIAÇÃO DA ATIVIDADE BIOLÓGICA DA FRAMBOESA (RUBUS IDAEUS L.). CONTRIBUIÇÃO PARA O DESENVOLVIMENTO DE UMA ALEGAÇÃO DE SAÚDE". 2019.
    10.22533/at.ed.8521926042
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/02/19 Reduction of inflammation and colon injury by a Spearmint phenolic extract in experimental bowel disease in mice 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20.ª Reunião de Toxicologia
Faculty of Pharmacy - Universidade de Lisboa (Lisbon, Portugal)
2020/11/05 Reduction of inflammation and colon injury by a Satureja hortensis L. (Savory) phenolic extract in experimental inflammatory bowel disease in mice Iberphenol International Conference
Universidade de Coimbra - Faculty of Pharmacy (Coimbra, Portugal)
2020/03/23 Nanocarriers with Sambucus nigra L. extract for anti-inflammatory activity 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
(Vienna, Áustria)
2020/02/10 Skin Delivery of Sambucus nigra L. extracts through nanocarriers 5th World Congress & Expo on Pharmaceutics & Drug Delivery Systems
(Lisbon, Portugal)
2019/09/30 Phytosomes with Persimmon (Diospyros kaki, L.) Extract: Preparation and Preliminary Demonstration of in vivo Tolerability 13th World Congress on Polyphenols Applications
(Valletta, Malta)
2019/09/21 Deflamin, a Non-Toxic Oglimer from Lupinus Albus Seeds, Resists Digestion and Inhibits Colitis by Targeting MMP-9 Activity in vitro and in vivo World Congress of Gastroenterology
(Istanbul, Turquia)
2019/08/27 Poster: Nanocarriers with Sambucus nigra L. Extracts for Skin Applications 26th International Conference on Bioencapsulation
(Strasbourg, França)
2019/07/28 Evaluation of the Anti-Inflammatory Activity of a Persimmon (Diospyros kaki, L.) Extract in Colitis and Rheumatoid Arthritis Rodent Models Natural Products in Drug Discovery and Human Health conference
Portuguese Chemistry Society at Faculty of Pharmacy, Universidade de Lisboa (Lisbon, Portugal)
2019/06/17 Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation, Characterization and In Vivo Preliminary Tolerability 3rd Edition of the Master activity of the Lusophone Academy of Pharmaceutical Sciences
Portuguese Foundation for Communications (Lisbon, Portugal)
2018/07/24 Phytosomes with Diospyros kaki Phenolic Extract: Preparation and Characterization 10th iMed.ULisboa and 3rd i3du Postgraduate Students Meeting
Universidade de Lisboa - Faculty of Pharmacy (Lisboa, Portugal)
2017/02/02 Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities. Annual Reunion of the Portuguese Pharmacology Society
Portuguese Pharmacology Scoiety (Coimbra, Portugal)
2016/09 Poster: "Intestinal Anti-inflammatory Activity of Grapefruit Juice in a Model of Rat Colitis", Best Analytical Poster Award Bioactives Conference: Food Bioactives and Health
John Innes Conference Centre in Norwich Research Park (Norwich, Reino Unido)
2014/07/02 Transient and Lasting Neurodegenerative Effects of Chronic Systemic Inflammation in Early Neonatal Mice 6th iMed.UL Postgraduate Students Meeting
Universidade de Lisboa - Faculty of Pharmacy (Lisboa, Portugal)
2014/06/15 Inflammation associated events and neurovascular disruption in neonatal sepsis Barriers of the CNS
Gordon Research Conference, Colby-Sawyer College New London (London, Reino Unido)
2013/07/18 Neonatal sepsis changes the pattern of microvascular coverage by astrocytes and microglia 5th Postgraduate iMed.UL Students Meeting
(Lisboa, Portugal)
2013/07/03 Neonatal Exposure to LPS Alters Microvascular and Glial Patterns in Different Brain Regions 13th ESNI Course
(Porto, Portugal)
2013/02/08 Evaluation of the anti-inflammatory activity of a persimmon (Diospyros kaki, L.) extract in an animal (Wistar rats) model of rheumatoid arthritis XLIII Annual Meeting of the Portuguese Pharmacological Society; XXXI Clinical Pharmacology Meeting; XII Toxicology Meeting
UMIB, ICBAS-University of Porto (Porto, Portugal)
2013/02/06 Neonatal Systemic Inflammation Differently Alters Regional Brain Microvasculature Beating the Blood-Brain & Other Blood Barriers Workshop
(Lisboa, Portugal)
2013 Glycogen synthase kinase-3 inhibition reduces liver, neuromuscular and lung injury caused by burn injury in the rat The European Shock Society 15th biennial conference
2012/12/20 Systemic Inflammation in the Neonatal Period Causes Microvasculature Alterations that May Differ Between Brain Regions and Neonatal Age 4th Postgraduate iMed.UL Students Meeting
Universidade de Lisboa - Faculty of Pharmacy (Lisboa, Portugal)
2011/06 The effect of raspberry in the postprandial inflammation in healthy humans
(Barcelona, Espanha)
2011 Phenolic compounds in raspberry samples - possible contribution to biological activity Iberoamerican Conference
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2010/07/17 Morphological evaluation of rat liver tissue after the subcutaneous injection of 1,2-dimethylhydrazine 16th World Congress of Basic and Clinical Pharmacology
(Copenhagen, Dinamarca)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2021/11/08 - 2021/11/12 Online Course on Stem Cell Technologies 2021
Oficina (workshop)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/20 - 2021/01/22 Course in Experimental Design and Analysis of Data for Research with Animals
Outro
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021 - Atual Biomolecules (2218-273X) MDPI
2020 - Atual Antioxidants (2076-3921) MDPI
2020 - Atual Biology (2079-7737) MDPI
2020 - Atual Food Research International (0963-9969) Elsevier
2020 - Atual Food & Function (2042-650X) Royal Society of Chemistry
2020 - Atual Heliyon (2405-8440) Cell Press
2020 - Atual International Journal of Dermatology (1365-4632) Wiley
2020 - Atual Materials (1996-1944) MDPI
2020 - Atual Molecules (1420-3049) MDPI
2020 - Atual Nutrients (2072-6643) MDPI
2020 - Atual Pharmaceutics (1999-4923) MDPI
2020 - Atual Pharmaceuticals (1424-8247) MDPI

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2020/12 - 2021/01 Malta Council for Science and Technology 2021-2025 Member of Proposals Evaluation Board for the Research Excellence Programme
Avaliador
Malta Council for Science and Technology, Malta Malta Council for Science and Technology

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2021/02 - Atual Project Peer Reviewer (10 projects evaluated of 250k each) of the Science Fund of the Republic of Serbia Science Fund of the Republic of Serba, Sérvia
2021/01 - Atual Martí-Franquès COFUND PhD Fellowship 2020-2022 Expert Evaluator 2020-2021: 14 candidates evaluated 2021-2022: 15 candidates evaluated and interviewed Universitat Rovira i Virgili, Espanha

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021 - Atual Immunology Unit Masters in Biomedical Sciences (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/02/01 - Atual Postgraduate Course on Laboratory Animal Sciences - Category B, and SPCAL (Portuguese Society of Laboratory Animal Sciences) Curso de Ciências em Animais de Laboratório (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2020/01 - Atual MSc Clinical Nutrition Quality Control and Food Toxicology (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
Distinções

Outra distinção

2015 PhD Grant - REITORIA/BD/FF01/2015
Universidade de Lisboa, Portugal