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Fátima Macedo is a team leader at Instituto de Investigação e Inovação em Saúde (i3S) in Porto, Portugal. She is also an Invited Assistant Professor at the Department of Medical Sciences (DCM), University of Aveiro (UA) where she teaches Immunology and Pathology. Fátima Macedo received a PhD in Biomedical Sciences in 2006, a master's degree in Immunology in 1999 and a BSc degree in Biology in 1996, all from University of Porto, Portugal. During her PhD and Masters degree she was a visiting student at Harvard University, Boston and Loyola University in Chicago, USA respectively. Her doctorate focused on T-lymphocyte biology in the context of iron overload. In this context, she addressed different diseases of iron overload with a genetic cause including Hemochromatosis. After her PhD, she developed an interest in a population of T lymphocytes that recognize lipids (CD1-restricted T lymphocytes). For more than 12 years, Fátima has been working on lipid specific T lymphocytes in Lysosomal Storage Diseases, mainly sphingolipidoses. Her research team focus is understanding the role of sphingolipids for the modulation of CD1 restricted T lymphocytes, including Natural Killer T cells, and understanding the role of this modulation in different pathological conditions including sphingolipidoses like Acid Sphingomyelinase Deficiency, Gaucher and Fabry diseases. Fatima Macedo established a line of research that joins the CD1 and LSD fields that has been recognised nationally and internationally, as illustrated by establishing relevant collaborations with international leaders in the field of CD1-restricted T cells and with clinicians of National and International Reference Centers for Hereditary Metabolic Diseases, illustrated by joint publications and successfully attracting national and international funding. Fatima successful graduated 18 MSc and 3 PhD students, and supervised 2 postdoc researchers. She published 29 papers including publications on the Molecular Genetic and Metabolism Journal, the official journal of the Society for Inherited Metabolic Disorders, as well as publications on The European Journal of Immunology and Nature Immunology. Fatima Macedo has received invitations for plenary talks and her work has received several awards including The Gaucher Generation Award and awards from the Portuguese Society of Metabolic Diseases.
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Identificação

Identificação pessoal

Nome completo
Maria de Fátima Matos Almeida Henriques de Macedo

Nomes de citação

  • Macedo, M Fatima
  • Macedo, Fatima

Identificadores de autor

Ciência ID
2615-7465-D6E0
ORCID iD
0000-0002-2252-6105

Endereços de correio eletrónico

  • fmacedo@ibmc.up.pt (Profissional)
  • mfmacedo@ua.pt (Profissional)

Moradas

  • Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)
  • Departamento de Ciências Médicas, Universidade de Aveiro Campus Universitário de Santiago Agra do Crasto - edifício 30, 3810-193, Aveiro, Aveiro, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2006
Concluído
 Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Transferrin and T cells in iron overload" (TESE/DISSERTAÇÃO)
2006
Concluído
 Ciências Biomédicas (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Transferrin and T Cells in Iron Overload" (TESE/DISSERTAÇÃO)
1999
Concluído
 Immunology Master (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Characterization of immunogenic human HLA-A* 0201 restricted CTL epitopes of Simian Virus 40" (TESE/DISSERTAÇÃO)
 Very Good by unanimity
1996
Concluído
 Biology (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
 16 out of 20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/10/01 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2011/01/01 - 2015/09/30 Investigador Auxiliar (carreira) (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/09/01 - 2010/12/31 Pós-doutorado (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/01/01 - 2006/06/30 Investigador (Investigação) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2001/06/01 - 2001/12/21 Investigador visitante (Investigação) Harvard Medical School Department of Genetics, Estados Unidos
1999/10/01 - 2000/03/31 Investigador visitante (Investigação) Massachusetts General Hospital, Estados Unidos
1997/07/01 - 1998/07/31 Investigador visitante (Investigação) Loyola University Chicago, Estados Unidos
1996/01/01 - 1996/06/30 Assistente de Investigação (carreira) (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/09/01 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade de Aveiro, Portugal
2016 - 2019 Professor Auxiliar Convidado (Docente Universitário) Universidade de Aveiro, Portugal
2013 - 2016 Professor Auxiliar (Docente Universitário) Universidade de Aveiro, Portugal
2004/04/01 - 2013/06/30 Professor Adjunto (Docente Ensino Superior Politécnico) Instituto Piaget, Portugal
Projetos

Bolsa

Designação Financiadores
2023/09/01 - 2024/08/31 Can Enzyme Replacement Therapy revert iNKT cell dysfunction in Acid Sphingomyelinase Deficiency patients?
SPDM 2023
Investigador responsável
Portuguese Foundation of Metabolic Diseases
Em curso
2023/03/01 - 2024/08/31 Characterization of invariant Natural Killer T cell phenotype and function in alpha-Galactosidase A deficiency
2022.01788.PTDC
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07/15 - 2022/07/14 Structural and functional characterisation of AB toxins targeting antigen-presenting cells and their application as cancer vaccines
PTDC/BIA-MIC/29910/2017
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2016 - 2019 Structured program on bioengineered therapies for infectious diseases and tissue regeneration
01-0145-FEDER-000012
Investigador
Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)
2015 - 2019 Characterization of glucosylceramide specific invariant Natural Killer T cells and B lymphocytes in Gaucher disease: implications in disease pathology
GZ-2014-11251
Investigador responsável
Genzyme Corporation
2017 - 2017 Antigen presentation in Gaucher disease
APBRF
Investigador responsável
American Portuguese Research Fund
2011/03 - 2014/11 Cross-talk between the pathogenic mechanisms of Lysosomal Storage Diseases and the lipid antigen presentation.
PTDC/SAU-ORG/110112/2009
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2013 Enzymatic Replacement treatment for Fabry disease: effect of lymphocyte populations
Imuno-Fabry
Investigador responsável
Instituto Piaget
2009 - 2012 Modifiers of Hemochromatosis expression: research of new markers of disease progression.
PIC/IC/82785/2007
Investigador
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2011/03/01 - 2014/11/30 The crosstalk between lipid antigen presentation and the pathogenic mechanisms of Lysosomal Storage Diseases
PTDC/SAU-ORG/110112/2009
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2014/11/30 Inter-relações entre os mecanismos patogénicos das Doenças de Sobrecarga Lisosomal e a apresentação de antigénios lipídicos
PTDC/SAU-ORG/110112/2009
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/04/01 - 2012/09/30 MODIFIERS OF EXPRESSION OF HEMOCHROMATOSIS: looking for new markers of disease prognosis
PIC/IC/82785/2007
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

European Molecular Biology Laboratory, Alemanha

Hospital Geral de Santo António SA, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2014 - 2014 The effect of Globotriaosylceramide on invariant Natural Killer T cell activation
SPDM2014
Investigador responsável
Sociedade Portuguesa de Doenças Metabolicas
Concluído
2011 - 2011 Cytokine production by iNKT cells in Fabry disease.
SPDM2011
Investigador responsável
Sociedade Portuguesa de Doenças Metabolicas
Concluído
Produções

Publicações

Artigo em revista
  1. Tiago Fonseca; M. Fátima Macedo. "Inherited Metabolic Disorders: From Bench to Bedside". Biomedicines (2024): https://doi.org/10.3390/biomedicines12010174.
    10.3390/biomedicines12010174
  2. Nuno Lopes; M Luz Maia; Cátia S. Pereira; Inês Mondragão-Rodrigues; Esmeralda Martins; Rosa Ribeiro; Ana Gaspar; et al. "Leukocyte Imbalances in Mucopolysaccharidoses Patients". Biomedicines (2023): https://www.mdpi.com/2227-9059/11/6/1699.
    10.3390/biomedicines11061699
  3. Inês Mondragão-Rodrigues; M. Fátima Macedo. "Buffy Coat Processing Impacts on Monocytes’ Capacity to Present Lipid Antigens". Biomedicines (2023): https://doi.org/10.3390/biomedicines11030833.
    10.3390/biomedicines11030833
  4. Olga Amaral; Mariana Martins; Ana Rita Oliveira; Ana Joana Duarte; Inês Mondragão-Rodrigues; M. Fátima Macedo. "The Biology of Lysosomes: From Order to Disorder". Biomedicines (2023): https://doi.org/10.3390/biomedicines11010213.
    10.3390/biomedicines11010213
  5. Borges SM; Santos C; Macedo MF. "Monocyte antigen-presenting capacity to iNKT cells is influenced by the blood collection conditions.". Journal of immunological methods (2023): http://europepmc.org/abstract/med/36638882.
    10.1016/j.jim.2023.113426
  6. J. Pedro Loureiro; Mariana S. Cruz; Ana P. Cardoso; Maria J. Oliveira; M. Fátima Macedo. "Human iNKT Cells Modulate Macrophage Survival and Phenotype". Biomedicines 10 7 (2022): 1723-1723. https://doi.org/10.3390/biomedicines10071723.
    10.3390/biomedicines10071723
  7. Mariana S. Cruz; José Pedro Loureiro; Maria J. Oliveira; Maria Fatima Macedo. "The iNKT Cell–Macrophage Axis in Homeostasis and Disease". International Journal of Molecular Sciences 23 3 (2022): 1640-1640. https://doi.org/10.3390/ijms23031640.
    10.3390/ijms23031640
  8. Carolina Pinto; Diana Sousa; Vladimir Ghilas; Andrea Dardis; Maurizio Scarpa; Maria Fatima Macedo. "Acid Sphingomyelinase Deficiency: A Clinical and Immunological Perspective". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222312870.
    10.3390/ijms222312870
  9. H. Ribeiro; M.I. Rocha; H. Castro; M.F. Macedo. "Chemical inhibition of ß-glucocerebrosidase does not affect phagocytosis and early containment of Leishmania by murine macrophages". Experimental Parasitology 216 (2020): 107939-107939. https://doi.org/10.1016/j.exppara.2020.107939.
    10.1016/j.exppara.2020.107939
  10. Espen Melum; Xiaojun Jiang; Kristi D. Baker; M. Fatima Macedo; Jürgen Fritsch; C. Marie Dowds; Jing Wang; et al. "Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin". Nature Immunology (2019): https://doi.org/10.1038/s41590-019-0504-0.
    10.1038/s41590-019-0504-0
  11. Pereira, Catia S.; Pérez-Cabezas, Begoña; Ribeiro, Helena; Maia, M. Luz; Cardoso, M. Teresa; Dias, Ana F.; Azevedo, Olga; et al. "Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.01264.
    Publicado • 10.3389/fimmu.2019.01264
  12. Pereira, C.S.; Ribeiro, H.; Pérez-Cabezas, B.; Cardoso, M.T.; Alegrete, N.; Gaspar, A.; Leão-Teles, E.; Macedo, M.F.. "The GM2 ganglioside inhibits iNKT cell responses in a CD1d-dependent manner". Molecular Genetics and Metabolism 125 1-2 (2018): 161-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049885297&partnerID=MN8TOARS.
    10.1016/j.ymgme.2018.07.005
  13. Belo, R.; Santarém, N.; Pereira, C.; Pérez-Cabezas, B.; Macedo, F.; Leite-de-Moraes, M.; Cordeiro-da-Silva, A.. "Leishmania infantum exoproducts inhibit human invariant NKT cell expansion and activation". Frontiers in Immunology 8 JUN (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021244202&partnerID=MN8TOARS.
    10.3389/fimmu.2017.00710
  14. Pereira, C.S.; Ribeiro, H.; Macedo, M.F.. "From lysosomal storage diseases to NKT cell activation and back". International Journal of Molecular Sciences 18 3 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85014064972&partnerID=MN8TOARS.
    10.3390/ijms18030502
  15. Deng, S.; Kain, L.; Pereira, C.S.; Mata, S.; Macedo, M.F.; Bendelac, A.; Teyton, L.; Savage, P.B.. "Psychosine variants as antigens for natural killer T cells". Chemical Science 8 3 (2017): 2204-2208. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014114931&partnerID=MN8TOARS.
    10.1039/c6sc04218j
  16. Pereira, C.S.; Macedo, M.F.. "CD1-restricted T cells at the crossroad of innate and adaptive immunity". Journal of Immunology Research 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008870052&partnerID=MN8TOARS.
    10.1155/2016/2876275
  17. Pereira, C.S.; Sa-Miranda, C.; De Libero, G.; Mori, L.; Macedo, M.F.. "Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner". European Journal of Immunology 46 1 (2016): 147-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953835270&partnerID=MN8TOARS.
    10.1002/eji.201545725
  18. Maia, M.L.; Pereira, C.S.; Melo, G.; Pinheiro, I.; Exley, M.A.; Porto, G.; Macedo, M.F.. "Invariant Natural Killer T Cells are Reduced in Hereditary Hemochromatosis Patients". Journal of Clinical Immunology 35 1 (2015): 68-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925510182&partnerID=MN8TOARS.
    10.1007/s10875-014-0118-0
  19. Quinta, R.; Rodrigues, D.; Assunção, M.; Macedo, M.F.; Azevedo, O.; Cunha, D.; Oliveira, P.; Sá Miranda, M.C.. "Reduced glucosylceramide in the mouse model of Fabry disease: Correction by successful enzyme replacement therapy". Gene 536 1 (2014): 97-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891827179&partnerID=MN8TOARS.
    10.1016/j.gene.2013.11.073
  20. Pereira, C.S.; Azevedo, O.; Maia, M.L.; Dias, A.F.; Sa-Miranda, C.; Macedo, M.F.. "Invariant natural killer T cells are phenotypically and functionally altered in Fabry disease". Molecular Genetics and Metabolism 108 4 (2013): 241-248. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875249971&partnerID=MN8TOARS.
    10.1016/j.ymgme.2013.01.018
  21. Macedo, M.F.; Quinta, R.; Pereira, C.S.; Sa Miranda, M.C.. "Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model". Molecular Genetics and Metabolism 106 1 (2012): 83-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860197221&partnerID=MN8TOARS.
    10.1016/j.ymgme.2012.02.014
  22. MacEdo, M.F.; Porto, G.; Costa, M.; Vieira, C.P.; Rocha, B.; Cruz, E.. "Low numbers of CD8+T lymphocytes in hereditary haemochromatosis are explained by a decrease of the most mature CD8+effector memory T cells". Clinical and Experimental Immunology 159 3 (2010): 363-371. http://www.scopus.com/inward/record.url?eid=2-s2.0-74549195700&partnerID=MN8TOARS.
    10.1111/j.1365-2249.2009.04066.x
  23. Balreira, A.; Macedo, M.F.; Girão, C.; Rodrigues, L.G.; Oliveira, J.P.; Sá Miranda, M.C.; Arosa, F.A.. "Anomalies in conventional T and invariant natural killer T-cell populations in Fabry mice but not in Fabry patients". British Journal of Haematology 143 4 (2008): 601-604. http://www.scopus.com/inward/record.url?eid=2-s2.0-54849425572&partnerID=MN8TOARS.
    10.1111/j.1365-2141.2008.07380.x
  24. Macedo, M.F.; de Sousa, M.. "Transferrin and the transferrin receptor: Of magic bullets and other concerns". Inflammation and Allergy - Drug Targets 7 1 (2008): 41-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-43449092561&partnerID=MN8TOARS.
    10.2174/187152808784165162
  25. MacEdo, M.F.; Cruz, E.; Lacerda, R.; Porto, G.; De Sousa, M.. "Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8+T lymphocyte numbers". Blood Cells, Molecules, and Diseases 35 3 (2005): 319-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744590510&partnerID=MN8TOARS.
    10.1016/j.bcmd.2005.08.001
  26. Macedo, M.F.; De Sousa, M.; Ned, R.M.; Mascarenhas, C.; Andrews, N.C.; Correia-Neves, M.. "Transferrin is required for early T-cell differentiation". Immunology 112 4 (2004): 543-549. http://www.scopus.com/inward/record.url?eid=2-s2.0-4043183284&partnerID=MN8TOARS.
    10.1111/j.1365-2567.2004.01915.x
  27. Velders, M.P.; Fatima Macedo, M.; Provenzano, M.; Elmishad, A.G.; Holzhütter, H.-G.; Carbone, M.; Martin Kast, W.. "Inhibition of p38MAP kinase potentiates the JNK/SAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation of HL60 cells". Journal of Cellular Biochemistry 82 1 (2001): 68-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034981648&partnerID=MN8TOARS.
    10.1002/jcb.1141
  28. Velders, M.P.; Macedo, M.F.; Provenzano, M.; Elmishad, A.G.; Holzhütter, H.-G.; Carbone, M.; Kast, W.M.. "Human T cell responses to endogenously presented HLA-A* 0201 restricted peptides of simian virus 40 large T antigen". Journal of Cellular Biochemistry 82 1 (2001): 155-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034986894&partnerID=MN8TOARS.
    10.1002/jcb.1148
  29. Macedo MF; Velders MP; Nieland JD; Rudolf MP; Weijzen S; Da Silva DM; Franke A; et al. "Cellular immunity and immunotherapy against deoxyribonucleic acid virus-induced tumors.". (1998): http://europepmc.org/abstract/med/9689811.
  30. Velders, M.P.; Nieland, J.D.; Rudolf, M.P.; Loviscek, K.; Weijzen, S.; De Visser, K.E.; Fatima Macedo, M.; Carbone, M.; Kast, W.M.. "Identification of peptides for immunotherapy of cancer. It is still worth the effort". Critical Reviews in Immunology 18 1-2 (1997): 7-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030721436&partnerID=MN8TOARS.
Capítulo de livro
  1. Helena Ribeiro; Catia Pereira; Macedo, M Fatima. "O potencial imunoterapêutico dos lípidos". In Bioquímica e Bem Estar. Portugal: Edições Afrontamento, 2018.
    Publicado
  2. Catia Pereira; Macedo, M Fatima. "Lipid antigen presentation to T cells.". In Current Research in Immunology, 65-78. Kerala, Índia: Research Media Press, 2011.
    Publicado
  3. Maria Graça Porto; Carla Sofia Cardoso; Macedo, M Fatima; Eugénia Cruz. "Hereditary Hemochromatosis Type I: Genetic, Clinical and Immunological Aspects". Fuchs H (ed) Transworld Research Network, 2008.
    Publicado
  4. Rudolf MP; Velders MP; Nieland JD; Franke A; Loviscek K; Weijzen S; Macedo, M Fatima; et al. "Vaccine design for DNA virus induced cancer". In Sourcebook on Asbestos Diseases, editado por GA Peters, BJ Peters (Eds.). Charlottesville, Estados Unidos: Lewis Publishing, Reed Elsevier, 1998.
    Publicado
  5. Velders MP; Nieland JD; Pierce BM; Macedo, M Fatima; Loviscek K; Mourer J; Kast WM. "Current status and future perspectives of the immunotherapy of cancer". In Handbook of Ocular Immunology, 181-203. Países Baixos: Aeolus Press, 1998.
    Publicado
Poster em conferência
  1. Freitas, Inês Lua; Macedo, Fatima; Oliveira, Liliana; do Vale, Ana; dos Santos, Nuno M.S.. "The NF-kB targeting toxin AIP56 has tropism for myeloid cells". Trabalho apresentado em ETOX 2023-EUROPEAN WORKSHOP ON BACTERIAL PROTEIN TOXINS, June 25 - June 29 2023, Crieff, UK, 2023.
  2. Freitas, Inês Lua; Macedo, Fatima; Oliveira, Liliana; do Vale, Ana; dos Santos, Nuno M.S.. "Cellular Specificity of AIP56, a Bacterial Toxin that Targets NF-¿B". Trabalho apresentado em XLVIII Annual Meeting of the Portuguese Society for Immunology, 29-31 March 2023, Aveiro, Portugal, 2023.
  3. Freitas, Inês Lua; Macedo, Fatima; Oliveira, Liliana; do Vale, Ana; dos Santos, Nuno M.S.. "Cellular Specificity of AIP56, a Bacterial Toxin that Targets NF-kB". Trabalho apresentado em I ImmunoHUB Annual Meeting - Infection & Immunity. i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 2023.
  4. Freitas, Inês Lua; Macedo, M Fatima; Oliveira, Liliana; do Vale, Ana; dos Santos, Nuno M.S.. "AIP56 Has Tropism for Myeloid Cells". Trabalho apresentado em 9th McBiology Symposium, 23rd and 24th February 2023, i3S, Porto, Portugal, 2023.
  5. Mondragão-Rodrigues, Inês; Borges, Sofia M; Macedo, M Fatima. Autor correspondente: Macedo, M Fatima. "Effects of distinct blood preservatives and processing on monocyte function". Trabalho apresentado em 15.º Encontro de Investigação Jovem da Universidade do Porto, 2022.
  6. Mondragão-Rodrigues, Inês; Borges, Sofia M; Macedo, M Fatima; Cláudia Santos. Autor correspondente: Macedo, M Fatima. "Monocyte function: the effect of different Buffy Coat processing and blood preservatives.". Trabalho apresentado em XLVII Sociedade Portuguesa Imunologia Annual Meeting 2022, 2022.
  7. Maia, Maria Luz; Pereira, Catia S.; Dias, Ana F; Rodrigues, Esmeralda; Cardoso, Teresa; Martins, Esmeralda; Aguiar, Patrício; et al. "Lymphocytes in Mucopolysaccharidosis type VI patients". Trabalho apresentado em ESGLD, 2013.
  8. Pereira, Catia S.; Maia, Maria Luz; Dias, Ana F.; Sa-Miranda, Clara; De Libero, G; Mori, L; Macedo, Fatima. "iNKT Cells in Gaucher and Fabry diseases". Trabalho apresentado em 7th International Symposium on CD1 and NKT cells, 2013.
  9. Dias, Ana F; Pereira, Catia S.; Maia, Maria Luz; Sa-Miranda, Clara; De Libero, G; Mori, L; Macedo, Fatima. "iNKT Cells And Lipid Antigen Presentation In Niemann-Pick Disease Type C". Trabalho apresentado em 7th International Symposium on CD1 and NKT cells, 2013.
  10. Maia, Maria Luz; Pereira, Catia S.; Ana, Dias F; Rodrigues, Esmeralda; Leão-Teles, Elisa; Sa-Miranda, Clara; Macedo, Fatima. "Lymphocytes and dendritic cells in Mucopolysaccharidosis type VI patients". Trabalho apresentado em XXXVIII Jornadas Portuguesas de genética, 2013.
  11. Pereira, Catia S.; Maia, Maria Luz; Dias, Ana F.; Vairo, Filippo; Azevedo, Olga; Rodrigues, Esmeralda; Cardoso, Teresa; et al. "Fabry and Gaucher disease patients present specific alterations in invariant Natural Killer T cells". Trabalho apresentado em XXXVIII Reunião anual da Sociedade Portuguesa de Imunologia, 2012.
Tese / Dissertação
  1. Macedo, M Fatima. "Transferrin and T cells in iron overload". Doutoramento, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2006.
  2. Macedo, M Fatima. "Characterization of immunogenic human HLA-A*0201 restricted CTL epitopes of Simian Virus 40". Mestrado, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 1999.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/11/29 Flow cytometry approach to study Lysosomal Storage Disease Inflammation Approaches for inflammation research: limitations and troubleshooting
Aveiro University (Online, Portugal)
2022/11/11 Does the level of substrate impact immunity status? Global Symposium on Lysosomal Storage Disorders (GSLSD) 2022
(Frankfurt, Alemanha)
2021/05/19 Basic principles of immunological memory and vaccination. Round table on COVID-19 Pandemic and Vaccination: opportunities and challenges
Aveiro University (Online, Portugal)
2021/04/29 Immunological response: with and without memory Pint of Science Aveiro
Pint of Science Aveiro (Online, Portugal)
2018/05/05 Lysosomal Storage Diseases – Implications of Glycosphingolipid storage for NKT cells Recent Advances in Rare Diseases (RARD)
(New Delhi, Índia)
2018/02/18 Specificity versus promiscuity in lipid recognition by the Immune System 7th workshop in Lipidomics
(aveiro, Portugal)
2017/11/05 Immune dysregulation in Fabry disease: Insights from the mouse models Genetic, Rare & Immune Disorders Symposium (GRIDS)
(Fairfax, Estados Unidos)
2017/07/03 “Implications of Glycosphingolipid storage in T cell Immunity MASSTRPLAN-Summer School”,
(aveiro, Portugal)
2016/10/24 NKT cells and CD1 Advanced course in Molecular Immunology”
(aveiro, Portugal)
2016/04/29 The cross talk between innate and adaptive immunity International Immunology Day
(Porto, Portugal)
2016/03/17 Lysosomal Storage Diseases - Implications of Glycosphingolipid storage in Immunity 12th International Symposium of the Portuguese Society of Metabolic Diseases
2015/05/06 Sphingolipids as Immune System Modulators 4th Workshop in Lipidomics
(Aveiro, Portugal)
2014/05/30 Immune System Dysfunction in Gaucher Disease Gaucher disease: new perspectives
(porto, Portugal)
2014/04/02 Lipids and lymphocyte immune response Science and Technology Week at the University of Évora
2013/11/22 Immune system in Gaucher disease 5th Gaucher Leadership Forum (GLF)
(Madrid, Espanha)
2013/03/14 The impact of sphingolipid storage in the immune system 4th National Days of Biomedical Sciences
(aveiro, Portugal)
2012/09/21 Immune dysregulation in Gaucher disease 4th Gaucher Leadership Forum (GLF)
(munich, Alemanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/09/01 - Atual Phenotypic and functional characterization of iNKT cells in Fabry disease patients
Orientador de Mariana Fragata Miranda
 Mestrado em Investigação Biomédica (Mestrado)
Universidade de Coimbra, Portugal
2021/09/01 - 2022/11/25 Buffy coat verus blood collection tube monocytes: a functional characterization
Orientador de Sofia de Morais Borges
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2020/09/15 - 2021/12/10 Effect of diferente buffy coat processing on monocyte function
Orientador de Inês Rodrigues
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2020/09/15 - 2021/12/09 Human iNKT cells as key modulators of macrophage survival and phenotype
Orientador de Mariana Cruz
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2019 - 2020/12/09 iNKT cells and MAIT cells in Gaucher disease
Orientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra, Portugal
2016/01/01 - 2020/12/05 The relevance of lipid accumulation in lysosomal storage diseases in immune cells function
Orientador de Helena Maria Moreira Ferreira Soares Ribeiro
 Doutoramento em Bioquímica
Universidade de Aveiro, Portugal
2018 - 2019 The Macrophage-iNKT cell axis: macrophage survival and activation are modulated upon invariant NKT cell interation
Orientador de José Pedro Loureiro
 Mestrado em Investigação Biomédica (Mestrado)
Universidade de Coimbra, Portugal
2017/09/01 - 2018/12/18 Characterisation of CD5 and CD6 expression by invariant Natural Killer Cells
Orientador de Ana Margarida Cunha
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2017/09/01 - 2018/12/13 Characterization of peripheral blood lymphocytes in Juvenile Idiopathic Arthritis
Coorientador de Claudia Marques
 Mestrado em Biologia Molecular e Celular (Mestrado)
Universidade de Aveiro, Portugal
2017/02/01 - 2018/11/30 Post Doc supervision. Post Doc research title: Lipid antigen presentation in Gaucher disease
Orientador de Begoña Perez
2012 - 2017 The peroxisomal matrix protein import machinery – a PEX5 – centered perspective
Coorientador
 Doutoramento em Ciências Biomédicas
Universidade do Porto, Portugal
2016/06/01 - 2016/12/31 Post Doc supervision of Catia Sofia Pereira. Project title: Lipid antigen presentation in Lysosomal Storage Diseases
Orientador de Catia Sofia Pereira
2015 - 2016 Dissecting the molecular basis for the arrest of Plasmodium sporozoites in the liver sinusoids
Coorientador
 Mestrado em Microbiologia (Mestrado)
Universidade de Aveiro, Portugal
2015 - 2016 The impact of Chronic Obstructive Pulmonary Disease on iNKT cells
Orientador de Tânia Marante
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2011 - 2016 Lipid specific T cells in Fabry, Tay-Sachs and Gaucher diseases
Orientador de Cátia Sofia Oliveira Pereira
 Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2015 Regulation of iron metabolismo in diferente bacterial infections
Coorientador de Patrícia Daniela Oliveira Ferreira
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2014 - 2015 B lymphocytes in MPS VI patients
Orientador de Cátia Daniela Isaías Pereira
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2013 - 2014 INKT Cells in Metabolic Diseases Hemochromatosis and Gaucher Disease
Orientador de Inês Pinheiro
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2013 - 2014 HIF-1alpha relevance in necrosis of Mycobacterium avium-induced granulomas
Coorientador de Marcos Cardoso
 Mestrado em Biologia Molecular e Celular (Mestrado)
Universidade de Aveiro, Portugal
2012 - 2013 Characterization of the NKT cell populations in MPS II patients
Orientador de Nuno Lopes
Universidade de Aveiro, Portugal
2011 - 2012 Lipid specific T cells in in MPS VI patients
Orientador
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
2010 - 2011 Lipid antigen presentation to T cells in Fabry disease
Orientador
 Mestrado em Biologia Aplicada ramo Biologia Molecular e Celular (Mestrado)
Universidade de Aveiro, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/05/04 - 2023/05/05 International Symposium on Integrative Medicine & Health-Drug discovery for human heath pandemic preparedness (2023/05/04)
Congresso (Coorganizador)
 Universidade de Aveiro, Portugal
2022/07/22 - 2022/07/22 2nd Workshop Sphingolipids in Health and Disease (2022/07/22 - 2022/07/22)
Congresso (Coorganizador)
 Universidade de Aveiro, Portugal
2014/09/18 - 2014/09/18 Organising symposium: "Sphingolipids in Health and Disease" (2014/09/18 - 2014/09/18)
Conferência (Coorganizador)

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/01/27 Studies on the diagnose and therapy of breast cancer
Vogal
 Fátima Liliana Ribeiro Vieira Monteiro (Doutoramento)
Universidade de Aveiro, Portugal
2021/12/10 Effect of diferente buffy coat processing on monocyte function
Orientador
 Inês Martins Mondragão Rodrigues (Mestrado)
Universidade de Aveiro, Portugal
2021/12/09 Human iNKT cells as key modulators of macrophage survival and phenotype
Orientador
 Mariana Santos Cruz (Mestrado)
Universidade de Aveiro, Portugal
2019/09/19 The Macrophage-iNKT cell axis: macrophage survival and activation are modulated upon invariante NKT cell interation
Orientador
 José Pedro Loureiro (Mestrado)
Hospitais da Universidade de Coimbra, Portugal
2018/12/21 Characterization of CD5 and CD6 expression by invariant Natural Killer T cells
Orientador
 Ana Margarida Cunha (Mestrado)
Universidade de Aveiro, Portugal
2018/12/13 Characterization of peripheral blood lymphocytes in Juvenile Idiopathic Arthritis
Vogal
 Cláudia Marques (Mestrado)
Universidade de Aveiro, Portugal
2018/05/29 Refining thymic epithelial cell differentiation: from progenitor cell isolation to the identification of discrete mature lineages
Vogal
 Helena Catarina Teixeira Meireles (Doutoramento)
Universidade do Porto, Portugal
2017/10/27 Impact of H-ferritin deficiency on macrophage viability and iron status
Arguente
 Gonçalo Augusto Taborda da Costa Laranja Mesquita (Mestrado)
Universidade da Beira Interior, Portugal
2017/09/22 Leishmania infantum extracellular material and human invariant natural killer T cells: a functional study
Vogal
 Renata Cardoso Belo da Costa (Mestrado)
Universidade do Porto, Portugal
2016/12/13 The impact of Chronic Obstructive Pulmonary Disease on iNKT lymphocytes
Orientador
 Tânia Marante (Mestrado)
Universidade de Aveiro, Portugal
2016/10/17 Heme and iron shape macrophage plasticity: a role in hemolytic disorders and cancer
Vogal
 Milene Soraia Costa da Silva (Doutoramento)
Universidade do Porto, Portugal
2016/05/03 Lipid-specific T cells in Fabry disease, Gaucher disease and GM2 gangliosidosis
Orientador
 Cátia Sofia Oliveira Pereira (Doutoramento)
Universidade do Porto, Portugal
2016/01/25 Impact of limp-2 deficiency on lysosome composition and function
Vogal
 Paulo Jorge Miranda da Silva Gaspar (Doutoramento)
Universidade do Porto, Portugal
2015/06 Studying the role of Lipocalin-2 in the pathophysiology of multiple sclerosis – looking beyond the brain
Arguente
 Sofia Pereira das Neves (Mestrado)
Universidade do Minho, Portugal
2015/04/03 B lymphocytes in patients with type VI Mucopolysaccharidosis
Orientador
 Cátia Daniela Isaías Pereira (Mestrado)
Universidade de Aveiro, Portugal
2014/12/03 A multiparametric assessment of thymic activity on HIV infected individuals on anti-retroviral therapy
Arguente
 Ana Patrícia Pimenta Martins Ribeiro (Mestrado)
Universidade do Minho, Portugal
2014/11/03 Functional characterization of immune cells presente in the adipose tissue of mice infected with Neospora caninum
Arguente
 João Pedro Silva Moreira (Mestrado)
Universidade do Porto, Portugal
2014/03/06 INKT Cells in Metabolic Diseases Hemochromatosis and Gaucher Disease
Orientador
 Inês Pinheiro (Mestrado)
Universidade de Aveiro, Portugal
2013/09/01 Study of the effect of genetic suppression of the Nrf2 signaling pathway in an animal model of spontaneous iron overload (Hfe knock-out)
Arguente
 Carolina Pontes Geraz Caldas (Mestrado)
Universidade de Aveiro, Portugal
2013/05/05 Mhc in Sea bass: molecular insights to class I antigen presentation
Vogal
 Rute Daniela Pinheiro da Silva Pinto (Doutoramento)
Universidade do Porto, Portugal
2013/05/03 Could the immunesenescence among aged individuals be related with their distinct cognitive performances?
Arguente
 Cláudia Sofia Serre Miranda (Mestrado)
Universidade do Minho, Portugal
2013/04/04 Towards the molecular understanding of BACE and Abeta physiological role in thymus development and function
Arguente
 Ana Cláudia da Rocha Ribeiro (Mestrado)
Universidade do Minho, Portugal
2013/03/05 INKT lymphocytes in patients with type II Mucopolysaccharidosis
Orientador
 Nuno Duarte Ribeiro Lopes (Mestrado)
Universidade de Aveiro, Portugal
2012/03/29 Immune System Involvement in Gaucher disease: analysis of HLA and KIR gene variants
Arguente
 Filippo Pinto E. Vairo (Mestrado)
Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Brasil, Brasil
2012/01/03 Lipid-specific T cells in patients with Mucopolysaccharidosis VI
Orientador
 Maria da Luz Galante Maia (Mestrado)
Universidade de Aveiro, Portugal
2011/03/04 Presentation of lipid antigens to T lymphocytes in patients with Fabry disease
Orientador
 Cátia Sofia Oliveira Pereira (Mestrado)
Universidade de Aveiro, Portugal
2009/01/05 MHC class I region in non-alcoholic steatohepatitis
Arguente
 Mónica Isabel Encarnação Costa (Mestrado)
Universidade de Aveiro, Portugal
2009/01/02 Differentiation of T lymphocytes in vitro in the presence of cells infected with Mycobacterium avium
Arguente
 Palmira da Conceição de Araújo Barreira da Silva (Mestrado)
Universidade de Aveiro, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2023/03/29 - 2023/03/31 48 Anual Meeting Portuguese Society for Immunology Portuguese Society of Immunology
2023/03/16 - 2023/03/18 XIII Jornadas Nacionais de Ciências Biomédicas Aveiro University

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2022 - 2022 Evaluator of research projects submited to "Innovate Competition", iMed Conference 14.0-Lisbon 2022. Student Association of Nova Medical School/ Medical Science Faculty, Universidade Nova de Lisboa.
Avaliador
2021/07 - 2021/08 Evaluation of Final Scientific Reports of Research and Development Units 2019
Avaliador
 Fundação para a Ciência e a Tecnologia
2021 - 2021 Evaluator of research projects submited to “Innovate Competition”, iMed Conference 13.0-Lisbon 2021. Student Association of Nova Medical School/ Medical Science Faculty, Universidade Nova de Lisboa.
Avaliador
2020 - 2020 Evaluator of research projects submited to “Innovate Competition”, iMed Conference 12.0-Lisbon 2020. Student Association of Nova Medical School/ Medical Science Faculty, Universidade Nova de Lisboa.
2019 - 2019 Evaluation of Scientific projects submitted to the PEPITA "Program to stimulate translational research projects" at Coimbra University
Avaliador
2018 - 2018 Evaluate research projects PEPITA: "program to stimulate translation research projects" at Coimbra University
2018 - 2018 Evaluate a research project for the Medical Research Council MRC
Avaliador
2016 - 2016 Evaluate research projects submitted to the “The Israel Science Foundation (ISF)”
Avaliador
2010 - 2010 Evaluate research projects submitted to the “The Israel Science Foundation (ISF)”

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2007 - Atual Invited assistant professor at the Biomedical Science degree of Aveiro University (Licenciatura) Universidade de Aveiro, Portugal
2004 - 2013 Teaching undergraduate students at the Health School Piaget Institute (Licenciatura) Instituto Piaget, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2015/06/06 - 2015/06/06 Interview at Antena 1 radio station, concerning my Award with the Gaucher Generation Award

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023 - 2023 Blood
2022 - 2023 Frontiers in Cellular and Infection Microbiology
2022 - 2023 Nano and Medical Materials
2022 - 2023 Frontiers in Cell and Developmental Biology
2022 - 2023 Biomedicines
2022 - 2023 PLOS ONE
2022 - 2023 Frontiers in Immunology
2022 - 2022 The FEBS Journal
2019 - 2022 Orphanet Journal of Rare Diseases
2018 - 2022 International Journal of Molecular Sciences
2020 - 2020 Cells
2020 - 2020 Clinical Immunology
Distinções

Prémio

2016 Honourable Mention in Immunology at the Janssen Innovation Prize competition
2014 Gaucher Generation Program (Award)

Outra distinção

2014 Genzyme Research Fellowship
2011 First Prize, in the 10th International Symposium on Lysosomal Storage Diseases, Poster in Basic Science
2011 Genzyme Research Fellowship