João Peça (2516-567A-D39A)

Curriculum Vitae

João Peça

João Peça (40M) is a neurobiologist with more than 15 years of research experience. Presently, he is Assistant Professor of Molecular and Cell Biology at the University of Coimbra and Group Leader of the Neuronal Circuits and Behavior Lab. João completed his Ph.D. at Duke University in 2011, where he created the first transgenic mice for channelrhodopsin-2 and pioneered the field of optogenetics. He did his postdoc at MIT characterizing animal models for autism, where he uncovered a new role for cortico-striatal dysfunction in autism spectrum disorders. In 2013 he was awarded a position as "FCT Investigator" in Portugal and in 2018 was offered a position as Principal Investigator to start an independent group at the Center for Neuroscience and Cell Biology, University of Coimbra. He has completed the supervision of 5 Ph.D. students' thesis and the supervision of 11 M.Sc. students. He is/was Principal investigator/Scientist-in-charge in 9 projects, co-PI in 6, and member of the research team in 2 research projects. Present interests of his group center on using advanced models to understand how genetic and environmental elements risk factors translate to neurodevelopmental and neuropsychiatric disorders. To achieve this, João uses a combination of molecular genetics, optogenetics and electrophysiological approaches using animal models and human brain organoids. To date his work has accrued >3600 citations and has led to primary research papers in high-impact, peer-reviewed journals, including Nature, Nature Communications, Molecular Psychiatry, PNAS, and Neuron, and review work in Current Opinion in Neurobiology, Cell and Annual Reviews in Neuroscience. He was awarded a Marie Curie Career Integration Grant, a NARSAD Young Investigator Award, and a prize from the Gulbenkian Foundation. In 2020 he received an IBRO Early Career Award. His recent work was also acknowledged with the "2019 Pfizer Prize" in Basic Research, the oldest and one of the most prestigious prizes in Portugal in the area of Biomedical Sciences. His group is composed of 5 PhD holding members and is funded by grants and awards from FCT, H2020, Bial Foundation, Takeda, IBRO, Pfizer and is also the coordinator of the ERA-Net Neuron Project "SHANKAstro".

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Identificação

Identificação pessoal

Nome completo: João Peça

Nomes de citação

Peça, João

Identificadores de autor

Ciência ID: 2516-567A-D39A
ORCID iD: 0000-0003-4989-2129

Endereços de correio eletrónico

jmpessa@gmail.com (Profissional)
jpeca@uc.pt (Profissional)

Telefones

Telefone

304502912 (Profissional)

Moradas

Center for Neuroscience and Cell Biology, Rua Larga, FMUC, 205b, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

https://pt.linkedin.com/in/jo%C3%A3o-pe%C3%A7a-6a8b89a (Profissional)
www.pecalab.com (Académico)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)

Formação

	Grau	Classificação
2013 Concluído	Postdoctoral Fellow (Postgraduate Certificate) Massachusetts Institute of Technology, Estados Unidos
2011 Concluído	Neurobiology (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal Duke University, Estados Unidos "Genetic and optogenetic engineering as a strategy to probe neuronal circuits" (TESE/DISSERTAÇÃO)	Com Distinção e Louvor \| Summa cum laude
2004 Concluído	Bioquímica (Licenciatura) Universidade de Coimbra, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2018/02/01 - 2019/08/31	Investigador principal (carreira) (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/07/01 - 2018/01/31	Investigador Auxiliar (carreira) (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2011/03/11 - 2013/12/31	Pós-doutorado (Investigação)	Massachusetts Institute of Technology, Estados Unidos

2005/06/01 - 2011/03/11	Investigador visitante (Investigação)	Duke University, Estados Unidos

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2019/09/01 - Atual	Professor Auxiliar (Docente Universitário)	Universidade de Coimbra, Portugal

2018 - 2019/08/31	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Coimbra, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2022 - Atual	Member of the Board of Education for Neurasmus: the European Master in Neuroscience	Universidade de Coimbra, Portugal
	Universidade de Coimbra, Portugal
2021/09/15 - Atual	Coordinator of the Master Degree in Cellular and Molecular Biology	Universidade de Coimbra, Portugal
	Universidade de Coimbra, Portugal
2020/09/22 - Atual	Member of the Board of Directors	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2018/02/01 - Atual	Group Leader	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Projetos

Bolsa

	Designação	Financiadores
2022 - Atual	SHANKAstro: Astrocytes dysfunctions in Phelan-McDermid syndrome: from mechanisms towards new therapeutic strategies NEURON/0002/2021 Investigador responsável Universidade de Coimbra, Portugal	European Commission Em curso
2022 - Atual	BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids EXPL/MED-OUT/1470/2021 Investigador Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021 - Atual	Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies PTDC/MED-NEU/5993/2020 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021 - Atual	The social code in cingulate-hippocampal circuits #074/2020 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação Bial Em curso
2020 - Atual	IBRO Early Carrer Award - Deficits in mGluR activity in GPRASP2 mutant mice ECA Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	International Brain Research Organization Em curso
2020 - Atual	A Saúde no Saber 45-2019/478 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Ciência Viva Em curso
2021 - 2022	NeuroCompute: Exploring the missing link between neuronal primary cilia dysfunction and neurophysiological properties using brain organoids and computational modelling NeuroCompute Investigador Universidade de Coimbra, Portugal	Universidade de Coimbra Concluído
2019 - 2022	Syn2Psy - Synaptic Dysfunction in Neuropsychiatric Disorders H2020-MSCA-ITN-2018-813986 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions Em curso
2018 - 2021/09/30	Alternate SNAPs in neurotransmitter release: from molecular function to neurocognitive dysfunction PTDC/BIA-CEL/29451/2017 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021/06/30	Cognitive disorders as defects in synaptic function: insight from human mutations in the CACNG2 gene PTDC/MED-NEU/28541/2017 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021/06	BrainEdition: remotely controlling gene edition in neural stem cells PTDC/NAN-MAT/28060/2017 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2020	ProTeAN - Production and Testing of humAn-derived Neurons and brain organoids: advanced model probing in neurodevelopmental disorders MSCA-IF-EF-RI-799164 Orientador	European Commission Em curso
2017 - 2020	BrainHealth2020: Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders CENTRO-01-0145-FEDER-000008 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	CENTRO2020 FEDER - Fundo Europeu de Desenvolvimento Regional
2018 - 2019/09	Exploring striatal postsynaptic SAPAP3 in Huntington’s disease Grant Number: 948 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	EHDN-European Huntington’s Disease Network Concluído
2017 - 2019	Early life stress and social hierarchies: the role of cortico-striatal circuits 216/16 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação Bial Concluído
2017 - 2019	The influence of maternal bonding in neuroimmune synaptic sculpting 264/2016 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação Bial
2016 - 2019	Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation PTDC/NEU-SCC/3247/2014 Investigador responsável	Secretaria de Estado de Ciência Tecnologia e Ensino Superior Concluído
2014 - 2017	NARSAD Young Investigator Grant 20733 Investigador responsável	Brain and Behavior Research Foundation
2013 - 2017	CELLSYNCIRCUITS: Cellular and synaptic dissection of the neuronal circuits of social and autistic behavior PCIG13-GA-2013-618525 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2011 - 2012	Autism Speaks Translational Fellow: Neural circuits of social behavior 7649 Investigador responsável Massachusetts Institute of Technology, Estados Unidos

Projeto

	Designação	Financiadores
2021 - Atual	Does healthy microglia rescue neuroinflammation and synaptic dysfunction in human cerebral organoids with FTD-associated mutations? 2020_119 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Takeda Pharmaceutical Company Limited

Outro

	Designação	Financiadores
2019 - Atual	Pfizer Award 2019 in Basic Research 2019 / Basic Research Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Pfizer Portugal Em curso
2013 - 2018	FCT Investigator Award IF/00812/2012/CP0151/CT0001 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016 - 2017	AidToC - Ab initio designed Tools for optogenetic Control of retinal circuits 141733 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação Calouste Gulbenkian Concluído
2013 - 2014/12/31	PROJECTO ESTRATÉGICO - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013 Pest-C/SAU/LA0001/2013-2014 Investigador CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia

Produções

Publicações

Artigo em conferência	Costa, Jéssica; Guedes, Joana; Franco, Lara; Peça, João; Cardoso, Ana Luísa. "Microglia morphology and density analysis: using stereology and 3D reconstruction to study the neuroimmune impact of early life stress". Trabalho apresentado em Paper presented in 52th International Congress on Microscopy and Microanalysis, Coimbra, 2018. Viegas, Ana Teresa; Carmona, Vítor; Almeida, Luis; Oliveira, Catarina Resende; Magalhães, João; Peça, João; Cardoso, Ana Luísa. "MicroRNA contribution in a new therapeutic strategy for Alzheimer’s disease". Trabalho apresentado em The 2016 Alzheimer’s Disease Congress, London, 2016.
Artigo em revista	Caldeira, Gladys Lima; Inácio, Ângela; Beltrão, Nuno; Barreto, Carlos A. V.; Ventura Rodrigues, Marina; Rondão, Tiago; Macedo, Renato; et al. "Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". Molecular Psychiatry (2022): https://www.nature.com/articles/s41380-022-01487-w. Publicado Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512-111512. https://doi.org/10.1016/j.mad.2021.111512. 10.1016/j.mad.2021.111512 Sequeira, Diana B.; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo J.; Ramos, Carlos; Figueiredo, Maria H.; Santos, Ana C.; et al. "Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials". Clinical Oral Investigations (2021): http://dx.doi.org/10.1007/s00784-021-03840-9. 10.1007/s00784-021-03840-9 Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al. "Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation". Science Signaling 14 670 (2021): eabb1953. http://dx.doi.org/10.1126/scisignal.abb1953. 10.1126/scisignal.abb1953 Lemos, Filipe; Prins, Caio; Carpi-Santos, Raul; Waclawiak, Ingrid; Sofia, Santos; Bernardes, Emerson; Peça, João; et al. "Galectin-3 in the Gut-liver axis Regulates Autistic-like Behaviors by Mechanism Associated with Cerebral Shank-3+ cell Niches in BALB/c Mice". Preprint (2021): Submetido Li, Yinqing; Lopez-Huerta, Violeta G.; Adiconis, Xian; Levandowski, Kirsten; Choi, Soonwook; Simmons, Sean K.; Arias-Garcia, Mario A.; et al. "Distinct subnetworks of the thalamic reticular nucleus". Nature 583 7818 (2020): 819-824. http://dx.doi.org/10.1038/s41586-020-2504-5. 10.1038/s41586-020-2504-5 Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Edfawy, Mohamed; et al. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". Neuropsychopharmacology 45 9 (2020): 1438-1447. http://dx.doi.org/10.1038/s41386-020-0727-7. Acesso aberto • 10.1038/s41386-020-0727-7 Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de Almeida, Luís; et al. "miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease". Molecular Therapy - Nucleic Acids 19 (2020): 1219-1236. http://dx.doi.org/10.1016/j.omtn.2020.01.010. Acesso aberto • 10.1016/j.omtn.2020.01.010 Lima Caldeira, Gladys; Peça, João; Carvalho, Ana Luísa. "New insights on synaptic dysfunction in neuropsychiatric disorders". Current Opinion in Neurobiology 57 (2019): 62-70. http://dx.doi.org/10.1016/j.conb.2019.01.004. 10.1016/j.conb.2019.01.004 Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al. "Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-09382-9. 10.1038/s41467-019-09382-9 Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João. "Effects of a New Bioceramic Material on Human Apical Papilla Cells". Journal of Functional Biomaterials 9 4 (2018): 74. http://dx.doi.org/10.3390/jfb9040074. 10.3390/jfb9040074 Santos, Tiago; Ferreira, Raquel; Quartin, Emanuel; Boto, Carlos; Saraiva, Cláudia; Bragança, José; Peça, João; et al. "Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles". Acta Biomaterialia 59 (2017): 293-302. http://dx.doi.org/10.1016/j.actbio.2017.06.044. Publicado • 10.1016/j.actbio.2017.06.044 Ting, Jonathan T.; Peça, João; Feng, Guoping. "Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders". Annual Review of Neuroscience 35 1 (2012): 49-71. http://dx.doi.org/10.1146/annurev-neuro-062111-150442. 10.1146/annurev-neuro-062111-150442 Peça, J.; Feng, G.. "Cellular and synaptic network defects in autism". Current Opinion in Neurobiology 22 5 (2012): 866-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867426528&partnerID=MN8TOARS. 10.1016/j.conb.2012.02.015 Peça, J.; Ting, J.; Feng, G.. "SnapShot: Autism and the synapse". Cell 147 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855174133&partnerID=MN8TOARS. 10.1016/j.cell.2011.10.015 Peça, J.; Feng, G.. "Neuroscience: When lights take the circuits out". Nature 477 7363 (2011): 165-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052602669&partnerID=MN8TOARS. 10.1038/477165a Peça, J.; Feliciano, C.; Ting, J.T.; Wang, W.; Wells, M.F.; Venkatraman, T.N.; Lascola, C.D.; Fu, Z.; Feng, G.. "Shank3 mutant mice display autistic-like behaviours and striatal dysfunction". Nature 472 7344 (2011): 437-442. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955536349&partnerID=MN8TOARS. 10.1038/nature09965 Arenkiel, Benjamin R.; Peça, João. "Using Light to Reinstate Respiratory Plasticity". Journal of Neurophysiology 101 4 (2009): 1695-1698. http://dx.doi.org/10.1152/jn.00009.2009. Acesso aberto • 10.1152/jn.00009.2009 Welch, Jeffrey M.; Lu, Jing; Rodriguiz, Ramona M.; Trotta, Nicholas C.; Peca, Joao; Ding, Jin-Dong; Feliciano, Catia; et al. "Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice". Nature 448 7156 (2007): 894-900. http://dx.doi.org/10.1038/nature06104. 10.1038/nature06104 Wang, H.; Peca, J.; Matsuzaki, M.; Matsuzaki, K.; Noguchi, J.; Qiu, L.; Wang, D.; et al. "High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice". Proceedings of the National Academy of Sciences* 104 19 (2007): 8143-8148. http://dx.doi.org/10.1073/pnas.0700384104. Acesso aberto • 10.1073/pnas.0700384104 Arenkiel, Benjamin R.; Peca, Joao; Davison, Ian G.; Feliciano, Catia; Deisseroth, Karl; Augustine, George J.; Ehlers, Michael D.; Feng, Guoping. "In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2". Neuron 54 2 (2007): 205-218. http://dx.doi.org/10.1016/j.neuron.2007.03.005. Acesso aberto • Publicado • 10.1016/j.neuron.2007.03.005
Capítulo de livro	Rodrigues, Artur Filipe; Rebelo, Catarina; Reis, Tiago; Sousa, João André; Pinho, Sónia L. C.; Sargento-Freitas, João; Peça, João; Ferreira, Lino. "Therapeutic Approaches for Stroke: A Biomaterials Perspective". In Engineering Biomaterials for Neural Applications, 185-218. Springer International Publishing, 2021. 10.1007/978-3-030-81400-7_8 Peça, João. "The Social Brain". In Cérebro – mais vasto que o céu. Lisboa: Fundação Calouste Gulbenkian, 2019. Publicado Caldeira, Gladys; Carvalho, Ana Luísa; Peça, João. "Schizophrenia". In Neurociências, editado por Duarte, Carlos; Rego, Cristina. Portugal: Lidel, 2017. Publicado Fernandes, Joana; Franco, Lara; Peça, João. "Autism Spectrum Disorders". In Neurociências, editado por Duarte, Carlos; Rego, Cristina; Oliveira, Catarina. Portugal: Lidel, 2017. Publicado Heyer, M.P.; Feliciano, C.; Peca, J.; Feng, G.. "Elucidating Gene Function through use of Genetically Engineered Mice". In Genomics. Wiley Online Books, 2010. 10.1002/9780470711675.ch10
Edição de número de revista	Xu, Junyu; Shi, Lei; Peça, João. "Autism Spectrum Disorder: New Insights Into Molecular Pathophysiology and Therapeutic Development". Frontiers in Cellular Neuroscience (2020): Publicado
Tese / Dissertação	Peça, João. "Genetic and optogenetic engineering as a strategy to probe neuronal circuits". Doutoramento, 2011.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2021/05/07	Reprogramming and stem cells in neurodevelopmental disorders	X Seminário da Sociedade de Pediatria do Neurodesenvolvimento (online)
2019/10/12	Cerebral organoids as research tools for neurodevelopmental disorders	Grupo de Estudos de Envelhecimento Cerebral e Demência Grupo de Estudos de Envelhecimento Cerebral e Demência (Curia)
2019	Abnormal mGlur-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice	Spring Meeting of the International Graduate School in Molecular Medicine Ulm University Ulm University (Ulm, Alemanha)
2019	Metabotropic glutamate receptors as a common dysfunction in neurodevelopmental disorders	Invited Seminar University of Edinburgh (Edinburgh, Reino Unido)
2019	Rain Man - Discussão sobre um filme que incide sobre autismo e Síndrome Savant	"Cérebro mais vasto que o céu" - The brain at the movies - Gulbenkian Foundation (Lisbon, Portugal)
2018	mGluR signaling in Autism Spectrum Disorders	ECMED Summer School– Extracellular Matrix in Epileptogenesis ECMED ITN (Warsaw, Polónia)
2017	Genetic dissection of Neuronal Circuits in autism spectrum disorders	In4Med Congress Medical Student Association - Faculty of Medicine, University of Coimbra (Coimbra, Portugal)
2016	Disruption of the mGLuR signaling network - a molecular focal point for ASDs	Neurodevelopmental Disorders: from neuroscience to the clinic Champalimaud Foundation & PIN (Progresso Infantil) (Lisbon, Portugal)
2016	Disruption of the mGluR signaling network - A molecular focal point for ASDs -	II Simpósio de pós-graduação em Biomedicina Universidade de Aveiro (Aveiro, Portugal)
2016	GPCR associated proteins - GPRASPing mGluR signalling dysfunction in autism spectrum disorders	Society of Neuroscience: Nanosymposium on Molecular and Cellular Mechanisms in Autism Models and other Developmental Diseases Society of Neuroscience (San Diego, Estados Unidos)
2014	Neuronal and Gene Networks Regulating Social Behavior	XVIII Congress of the Portuguese Society for Biochemistry Portuguese Society for Biochemistry (Coimbra, Portugal)
2011	Genetic and optogenetic engineering to manipulate and probe neuronal circuits and behavior	IX Encontro Anual do CNC Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2011	Shank synaptic genes in autism: Human genetics to mouse models and therapeutics	IMFAR - 2011 International Meeting for Autism Research (San Diego, Estados Unidos)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2019 - 2020	Impact of early-life stress on microglia: Neuron dynamics in the medial prefrontal cortex Coorientador de Solange Martins Nogueira	Biologia Celular e Molecular (Master) (Mestrado) Universidade de Coimbra, Portugal
2018 - 2019	Microglia-mediated remodelling of the cerebellar circuit Orientador de Pedro António Cruz Ferreira	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2017 - 2018	Optogenetic modulation of corticoestriatal activity for the regulation of social dominance Orientador de José Pedro Pinto Sampaio	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2017 - 2018	The role of GPRASP2 on mGluR5 signalling Orientador de Mariana Barradas Serrano Laranjo	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2014 - 2018	Long-term impact of early life stress on adult social behavior and prefrontal cortical circuits Orientador de Lara Oliveira Franco	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra, Portugal
2016 - 2017	Characterization of Gprasp2 knockout mice as a new model for autism spectrum disorders Orientador de Marta Isabel Ferreira Leite Pereira	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2016 - 2017	The role of cortico-striatal circuits in social hierarchies Orientador de Tiago João Dos Santos Reis	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2013 - 2017	Dissecting the role of GPRASP2 in autism spectrum disorder and intellectual disability Orientador de Mohamed Edfawy Soliman Hussien	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra, Portugal
2013 - 2017	The role of stargazin in the pathogenesis of psychiatric disorders Coorientador de Gladys Tarcila Lima Caldeira	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra, Portugal
2015 - 2016	Dissection of hierarchy formation in mice: behavioral and molecular correlates of dominance Orientador de Renato José Melo Sousa	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2014 - 2015	Optogenetics and biotechnology : production and in vitro characterization of Ab-Initio designed channelrhodopsin-2 mutants Orientador	Biotecnologia Farmacêutica (Mestrado) Universidade de Coimbra, Portugal
2013 - 2014	Intelligent design of color-tuned ChR2 variants for optogenetics applications Orientador de Bruno Cruz	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2013 - 2014	Molecular mechanisms of the synaptic and cognitive effects of ghrelin Orientador de Mário Jorge Da Silva Carvalho	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2013 - 2014	Expression and purification of Channelrhodopsin-2 in Pichia pastoris: generation of blue-shifted and redshifted optogenetic variants Orientador de Fabio Mazza	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2014 - Atual	Neuronal Circuits and Behavior: Advanced course (2014) Oficina (workshop) (Presidente da Comissão Organizadora)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - 2021	XVI Meeting of the Portuguese Society for Neuroscience (2020 - 2021) Encontro (Membro da Comissão Organizadora)	Sociedade Portuguesa de Neurociências, Portugal
2016/07 - 2016/07	7th ISN Special Neurochemistry Conference (2016/07 - 2016/07) Conferência (Coorganizador)	International Society for Neurochemistry, Suiça

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2021/10/15 - 2021/10/15	Round table participation in "FIC.A". A portuguese initiative to promote science and education. Mesa-redonda	Neurociência³ - Três formas de estudar o cérebro Festival Internacional de Ciência, FICA, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2022/03/18	A comprehensive characterization of cerebellar pathology in an animal model of Spinocerebellar Ataxia Type 3 Arguente principal	Ana Catarina Coutinho Vilaça Ferreira (Mestrado) Universidade do Minho, Portugal
2021/12/14	Optogenetic activation of intracelular adenosine A2A receptor signaling in the amygdala as a model of stress in rodents Arguente principal	Catarina Bernardino Carreira (Mestrado) Universidade de Coimbra, Portugal
2021/11/23	Phenotypic architecture and genetic polymorphisms associated with social behaviour in Zebrafish Arguente principal	Cláudia Gonçalves (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/11/22	Unravelling the activity patterns of midbrain dopaminergic neurons during male sexual behaviour Arguente principal	Silvana da Costa Araújo (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/11/19	NMR metabonomics applied to synaptosomes and slices to profile metabolic alterations in neurodegenerative and neuroprotective mechanisms Arguente	Andreia Filipa Simões Oliveira (Mestrado) Universidade de Coimbra, Portugal
2021/04/28	Striatal plasticity upon learning of a lateralized motor task Arguente principal	Ana Margarida Pinto (Mestrado) Universidade Nova de Lisboa, Portugal
2021/02/26	Cell-type specific neuronal manipulation of cortex and striatum during action selection Arguente principal	Rodrigo Ferreira Mantins (Mestrado)
2020/12/17	Cell-type specificity of cortico-cortical connections between the visual and retrosplenial cortices of the mouse Arguente	Ana Beatriz Simões Sá e Moura (Mestrado) Universidade de Coimbra, Portugal
2020/12/14	Revealing the role of neocortical circuit defects in cognitive alterations in autism spectrum disorder Arguente principal	Maria José Gueidão Costa (Mestrado) Universidade de Coimbra, Portugal
2020/11/02	Analysis of the hippocampal and cortex proteome of mice exposed to psychotropic medication Arguente	Cátia João Monteiro da Santa (Doutoramento) Universidade de Coimbra, Portugal
2020/07/07	Oxytocinergic modulation of social information use in threat perception Arguente principal	Ibukun Dorcas Fatunke Akinrinade (Doutoramento) Universidade Nova de Lisboa, Portugal
2020/07/02	Cortico-hippocampal interactions as a neural substrate for the retrieval of contextual memories in choice behavior Arguente	Emanuel Ferreira Fernandes (Doutoramento) Universidade Nova de Lisboa, Portugal
2020/06/29	Impact of human iPSC-derived NESC transplantation in MJD-associated neuropathology and motor impairments Arguente principal	Ana Catarina Paulino do Ó Vinhas (Mestrado) Universidade de Coimbra, Portugal
2020/06/19	Role of TET3 enzyme in brain function Arguente principal	Cláudia Antunes (Doutoramento) Universidade do Minho, Portugal
2020/01/13	The Computational Roles of Dopamine and Serotonin in Tourette Syndrome and Obsessive-Compulsive Disorder Vogal	Vasco Manuel Aranha da Conceição (Doutoramento) Universidade de Lisboa, Portugal
2019	Mate choice and social preference in Mus musculus females Arguente principal	Luís Fernando Gomes Moreira (Doutoramento) Universidade Nova de Lisboa, Portugal
2019	Mechanisms of Self-Defense Suppression of Mothers Under Threat in the Presence of Offspring Arguente principal	Elizabeth Maria Rickenbacher (Doutoramento) Universidade Nova de Lisboa, Portugal
2019	The Computational Roles of Dopamine and Serotonin in Tourette Syndrome and Obsessive-Compulsive Disorder Arguente	Vasco Manuel Aranha da Conceição (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2019	Investigating potential treatment strategies and underlying mechanisms in the Fragile X Syndrome mouse and rat models Arguente principal	Melania Muscas (Doutoramento) The University of Edinburgh, Reino Unido
2019	Neurobehavioural and molecular mechanisms of social learning in zebrafish Arguente principal	Júlia Sabrina Ferreira Pinho (Doutoramento) Instituto Universitário de Ciências Psicológicas Sociais e da Vida, Portugal
2019	Targeting adenosine A2A receptors to manage Angelman syndrome symptoms Arguente principal	Ana Teresa Capitão Moreira de Sá (Mestrado) Universidade de Coimbra, Portugal
2019	Investigating the structural and physiological properties of ventromedial hypothalamic neurons across the estrous cycle of female mice Arguente principal	Ines Correia Dias (Mestrado) Universidade de Coimbra, Portugal
2018/12/20	Role of laterodorsal tegmentum in motivation and reward Arguente principal	Bárbara Guimarães Salazar Coimbra (Doutoramento) Universidade do Minho, Portugal
2018	Measuring dopamine release in different domains of the striatum during the development of habitual reward seeking. Arguente principal	João Manuel Silveira De Matos (Mestrado) Universidade de Coimbra, Portugal
2018	Mapping the neural circuitry underlying spatial and temporal locomotor adaptation Arguente principal	Marta Rocha Maciel (Mestrado) Universidade de Coimbra, Portugal
2017	The Role of the PgR+ cells of the Ventromedial Hypothalamus (VMHvl) in Female Mice Sexual Receptivity Arguente principal	Inês Mendes Preguiça (Mestrado) Universidade de Coimbra, Portugal
2017	Unravelling the circuits involved in ejaculation in mice (Mus musculus) Arguente principal	Ana Rita Pimentel Mendes (Mestrado) Universidade de Coimbra, Portugal
2016	Role of Nucleus accumbens dopamine D1- and D2-expressing neurons in reward and motivation Arguente principal	Carina Isabel Soares Da Cunha (Doutoramento) Universidade do Minho, Portugal
2016	Contribution of the ventro-lateral periaqueductal grey matter to fear conditioned analgesia Arguente principal	Nanci Aléxia Vieira Winke (Mestrado) Universidade de Coimbra, Portugal
2015	Contextualizing experience: plasticity pf cortical and subcortical systems for controlling auditory perception Arguente	Ana Raquel Oliveira Martins (Doutoramento) Universidade de Coimbra, Portugal
2015	Neural and behavioral correlates of decision confidence. Arguente	Gil Miguel Pereira da Costa (Doutoramento) Universidade de Coimbra, Portugal
2015	The role of serotonin in behavior: Shining light on the maestro of the brain Arguente	Patrícia Correia (Doutoramento) Universidade Nova de Lisboa, Portugal
2015	Synaptic and circuitry mechanisms of basal ganglia dysfunction in compulsive and repetitive behavior Arguente	Patrícia Isabel Rodrigues Monteiro (Doutoramento) Universidade de Coimbra, Portugal
2015	Estudo da potencial toxicidade do processo de silenciamento da ataxina 3 mutante humana mediado por shRNA lentiviral Arguente principal	José Miguel Antunes Codêsso (Mestrado) Universidade de Coimbra, Portugal
2015	GADD45ß : a novel long-term memory mediator Arguente principal	David Vilhena Catarino Brito (Mestrado) Universidade de Coimbra, Portugal
2015	Dissociating the role of interneurons in sensory processing Arguente principal	Inês Vitória Barreiros (Mestrado) Universidade de Coimbra, Portugal
2015	Circuit plasticity during up-states in mouse barrel cortex Arguente principal	Emanuel Oliveira (Mestrado) Universidade de Coimbra, Portugal
2014	Dimensions of compulsivity – on the relation between compulsive grooming, anxiety and cognitive flexibility, and the effect of deep brain stimulation Arguente principal	Cindy Maria De Oliveira Pinhal (Mestrado) Universidade de Coimbra, Portugal
2014	Prosocial choice in rats depends on rewards received and food-seeking behaviour displayed by recipients Arguente principal	Diana Paula Ferreira Da Costa (Mestrado) Universidade de Coimbra, Portugal
2013	Epileptogenesis and Therapeutic Options in a Tuberous Sclerosis Complex Epilepsy Mouse Model Arguente principal	Catia Alexandra Pinho Silva (Mestrado) Universidade de Coimbra, Portugal
2013	Mapping the Serotonergic System : Topographical Organization of Serotonergic Projections from the Dorsal Raphe Nucleus Arguente principal	Katherine Louise Turco (Mestrado) Universidade de Coimbra, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2019/05 - Atual	XVI Meeting of the Portuguese Society for Neuroscience
2021/03/10 - 2021/03/31	Brain Gain - Brain Awareness Week	Center for Neuroscience and Cell Biology

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2020 - Atual	Frontiers in Behavioral Neuroscience	Frontiers
2019 - Atual	Frontiers in Cellular Neuroscience (1662-5102)	Frontiers Media SA

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2013 - Atual	Ad Hoc reviewer for: Nature, Nature Neuroscience, Nature Medicine, Molecular Psychiatry, Neuron, Molecular Autism, PLOS One, Nature Communications, Journal of Pediatric Genomics, Journal of Neuroscience Methods, Frontiers in Cellular Neuroscience

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2020/11/12 - 2020/11/12	Advanced Imaging Methods in Neuroscience: Optogenetic labeling for monitoring and control of neuronal activity	Optogenetic labeling for monitoring and control of neuronal activity (Doutoramento)	Universidade de Coimbra, Portugal

Entrevista / Programa (rádio / tv)

	Programa	Tema
2020/11 - 2020/11	A Saúde no Saber	As vacinas causam autismo?
2019/12/11 - 2019/12/11	RTP 1 - Main Portuguese TV Channel - Outras Histórias - O Código do Autismo	Autism
2019/12/04 - 2019/12/04	SIC Noticias - National TV News channel	Autism
2014/11/13 - 2014/11/13	"Até os ratos são generosos" - TSF - Portuguese Radio Station	Commentary on prosocial behavior
2008/09/12 - 2008/09/12	"Loucura Consciente" - TSF - Portuguese Radio Station	Commentary on obsessive compulsive disorder reporting by TSF, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2016 - Atual	Society for Neuroscience	Member
2016 - Atual	International Society for Neurochemistry	Member
2013 - Atual	Portuguese Society for Neuroscience	Member

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2019 - Atual	Grant Reviewer	Agence nationale de la recherche, França
2019 - Atual	Evaluator for FCT Grants - Final progress report	Fundação para a Ciência e a Tecnologia, Portugal
2018 - Atual	Grant Reviewer	Graduate Women in Science, Estados Unidos

Tutoria

	Tópico	Nome do aluno
2017 - Atual	Postdoctoral Fellow	Joana Guedes
2017 - Atual	Postdoctoral Fellow	Catarina Seabra

Distinções

Prémio

2022	2022 Teaching Innovation Award Universidade de Coimbra, Portugal Banco Santander Portugal, Portugal
2020	IBRO Early Career Award International Brain Research Organization, França
2020	FENS-IBRO/PERC Federation of European Neuroscience Societies, Bélgica
2019	Prizer Prize Pfizer Portugal, Portugal
2014	NARSAD Young Investigator Award Brain and Behavior Research Foundation, Estados Unidos

Título

2013	FCT Investigator Fundação para a Ciência e a Tecnologia, Portugal
2011	Autism Speaks Translational Fellow Autism Speaks, Estados Unidos