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A. Cristina Rego (Ph.D.) is Tenure Associate Professor with Aggregation at the Faculty of Medicine, University of Coimbra (FMUC) and head of ‘Mitochondria and Neurodegenerative Disorders’ (MiND) research group at the Center for Neuroscience and Cell Biology (CNC), Univ. Coimbra (UC), and CIBB (Centro de Inovação em Biomedicina e Biotecnologia). AC Rego obtained the Ph.D. in Cell Biology in 1999 at UC under supervision of Prof. Catarina R. Oliveira, was postdoctoral researcher in the Lab of Prof. David G. Nicholls, Univ. Dundee, Scotland, UK, and visiting researcher at the Buck Institute, Novato, CA, USA, from 1998-2000. In 2004-05 AC Rego was the coordinator of the BEB PhD Programme at CNC. Currently, she coordinates the Master in Molecular and Translational Neuroscience at FMUC. AC Rego investigates molecular mechanisms of familial and age-related neurodegenerative disorders, including Alzheimer's and Huntington's diseases, focusing on changes in mitochondrial function, dynamics and biogenesis, metabolic deregulation and related exosomal content, as well as glutamatergic postsynaptic dysfunction, and transcriptional deregulation. Funding has been garnered by HighQ Foundation (USA), Lundbeck Foundation, 'Instituto de Investigação Interdisciplinar' (IIIUC), 'Fundação para a Ciência e a Tecnologia' (FCT) and EHDN-European Huntington’s Disease Network projects, two 1st edition major prizes/awards promoted by Santa Casa da Misericórdia de Lisboa (SCML) and Fundação Luso Americana para o Desenvolvimento (FLAD), and through industry contracts (e.g. TEVA, Sigma-Tau, Mycology Lab, Prilenia Neurotherapeutics). AC Rego holds a h-factor 45 (Web-of-Science; h-factor 51 and i10 of 110, at Google Scholar) and >8000 citations, published 128 peer-reviewed publications (of which 101 original articles), 25 book chapters (11 in portuguese) and more than 125 abstracts in research meetings. AC Rego supervised/co-supervised the work of 10 post-doctoral fellows and a 'Ciência-FCT' researcher, 19 Ph.D. students and 46 Master students (concluded degrees). AC Rego acts as ad-hoc reviewer for scientific journals (e.g. Acta Neuropathologica, Antioxidants and Redox Signal., Brain, Cell Death & Disease, Eur. J. Neuroscience, Free Radic. Biol. and Medicine, Mol. Neurobiol., Neurobiol. Disease, Neuroscience, Redox Biology, Sci. Reports) and funding bodies, namely Parkinson's UK, Alzheimer's Research UK, Austrian Science Fund (FWF), Agence Nationale de la Recherche (ANR), Auckland Medical Research Foundation (AMRF), Telethon Fondazione, Israel Science Foundation, Wellcome Trust, Alzheimer's Association, COST or JPND. ACR was member of the ERA-Chair recruitment and monitoring team ERAatUC, at University of Coimbra and member/vogal of the board of CNC-UC. Currently, ACR is Vice-President of the Portuguese Brain Council and President of the Portuguese Society for Neuroscience (SPN).
Identificação

Identificação pessoal

Nome completo
Ana Cristina Carvalho Rego

Identificadores de autor

Ciência ID
1B13-BB39-7943
ORCID iD
0000-0003-0700-3776
Google Scholar ID
https://scholar.google.com.br/citations?hl=pt-PT&user=Z90leqsAAAAJ
Researcher Id
L-4272-2014
Scopus Author Id
7006684894

Endereços de correio eletrónico

  • acrego@cnc.uc.pt (Profissional)
  • arego@fmed.uc.pt (Profissional)

Telefones

Telefone
  • 239820190 (Profissional)

Websites

Projetos

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/06 - 2022/07/04 iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics
PTDC/BTM-TEC/29621/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/07/06 - 2022/06/30 Transcriptional activity modulation in Alzheimer's disease by inhibitors of histone deacetylases
PTDC/MED-TOX/32316/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/04/01 - 2015/09/30 Role of sirtuin 3 on mitochondrial function and deacetylation of mitochondrial targets: relevance for Huntington's disease
EXPL/BIM-MEC/2220/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/03/01 - 2015/09/30 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
EIT-KIC/IVE/0043/2013
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/05 - 2013/08/04 Analysis of transcription deregulation in brain and peripheral Huntington's disease models - influence of modulating histone deacetylases
PTDC/SAU-FCF/108056/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/05 - 2013/07/31 Deciphering the molecular mechanisms linking alpha-synuclein dysfunction and cytotoxicity in Parkinson's disease - the role of GDNF
PTDC/SAU-NEU/101928/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/06/01 - 2013/06/30 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
PTDC/SAU-NEU/103538/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/09/01 - 2010/12/31 Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer's disease
PTDC/SAU-NEU/71675/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/07/01 - 2010/12/31 Silencing Machado-Joseph disease: lentiviral-mediated RNA interference to ataxin-3
PTDC/SAU-FCF/70384/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/09/01 - 2010/11/30 Neuroprotective role of insulin and IGF-1 against Huntington´s disease-associated diabetes
PTDC/SAU-FCF/66421/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/09/01 - 2008/08/31 Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin-3 gene silencing by lentiviral vectors-mediated delivery of double-stranded RNAs
POCI/SAU-MMO/56055/2004
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/09/01 - 2008/08/31 Transcription regulation by FK506 and BDNF control mitochondrial dependent cell death - a protective role in Huntington's disease
POCI/SAU-NEU/57310/2004
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/07/01 - 2008/06/30 Biochemical and Behavioural Study of Opioid-Cocaine Interactions
POCI/SAU-FCF/58330/2004
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Capítulo de livro
  1. Cunha-Oliveira, Teresa; Rego, Ana Cristina; Carvalho, Félix; Oliveira, Catarina R.. "Medical Toxicology of Drugs of Abuse". 2013.
    https://doi.org/10.1016/B978-0-12-398336-7.00017-6
Tese / Dissertação
  1. Dioli, Chrysoula. "Chronic stress and glucocorticoid actions in brain plasticity and Tau pathology". Doutoramento, 2021. http://hdl.handle.net/1822/75899.
  2. Rego, Ana Cristina Carvalho. "Influence of reactive oxygen species and glutamate on the cytotoxicity of cultured retinal cells : a model of neuronal ischaemia". Doutoramento, 1999. http://hdl.handle.net/10316/10180.