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João Ramalho-Santos. PhD in Cell Biology in 1997 at the University of Coimbra, where he is. Is Full Professor (Department of Life Sciences) and Researcher at The Center for Neuroscience and Cell Biology of the University of Coimbra. Published 140 articles in journals. Has 2 section(s) of books and 3 book(s). Works in the area(s) of Natural sciences and Medical and Health Sciences with emphasis on the metabolic aspects regulationg Reproductive and Stem Cell Biology, and with additional interests also in Bioethics and Science Communication. Has interacted with 282 collaborator(s) in co-authorship of scientific papers. H-index 39 (ISI) and 48 (Google), K-index 141. Is an active Mamber of the Society for the Study of Reproduction, European Academy of Andrology, Society for Reproduction and Fertility,Portuguese Society for Reproductive Medicine and European Testis Workshop. He is an Associate Editor for Reproduction, having held the same post in Human Reproduction and Human Reproduction Update. He is a reviewer for over 30 journals (130 Reviews confirmed in Publons) and 6 agencies (Including FCT, Portugal, MRC, UK, DFG, German, and in National agencies in The Netherlands, Poland, Italy, Romania, Estonia, Kuwait, UAE, Iran and India). He is a former member of the National Ethics Council for the Life Sciences (CNECV)
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Identificação

Identificação pessoal

Nome completo
João RamalhoSantos
Data de nascimento
1966/07/04
Género
Masculino

Nomes de citação

  • Ramalho-Santos, João

Identificadores de autor

Ciência ID
0613-688D-A30E
ORCID iD
0000-0002-1172-4018
Google Scholar ID
https://scholar.google.pt/citations?hl=en&user=6I6DIgYAAAAJ&view_op=list_works&cstart=0&pagesize=20
Researcher Id
F-8641-2012
Scopus Author Id
798354

Telefones

Telemóvel
  • 919588244 (Pessoal)

Moradas

  • Department of Life Sciences, Calçada Martim de Freitas, 3000-456, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1138&idgrp=1140 (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas
  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Ética Relacionada com a Biotecnologia Médica
  • Ciências Sociais - Ciências da Comunicação

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B2)
Formação
Grau Classificação
2020 - 2020
Concluído
 Medicina Narrativa (Curso de Especialização Tecnológica)
Universidade Católica Portuguesa, Portugal
 19
2013/01/20
Concluído
 Agregação em Biociências (Título de Agregado)
Universidade de Coimbra, Portugal
 Approved
1997
Concluído
 Biologia (Doutoramento)
Especialização em Especialidade: Biologia Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Actividade Fusogénica de Vírus com Envelope Lipídico - Fusão de Membranas Promovidas Pelos Vírus Influenza e Sendai" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

1997/09/01 - Atual Investigador (Investigação)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

2019/01/14 - Atual Professor Catedrático (Docente Universitário)
Universidade de Coimbra, Portugal
2016 - 2018 Professor Associado (Docente Universitário)
Universidade de Coimbra, Portugal
2013 - 2016 Professor Associado (Docente Universitário)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Cargos e Funções

2017 - 2020 Conselho geral ou orgão correspondente
Universidade de Coimbra, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - 2021/12/31 HealthyAging2020
CENTRO-01-0145-FEDER-000012-N2323.
Investigador responsável
Universidade de Coimbra, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
2018 - 2021/03 STEM@REST: A novel pluripotency stem cell state and its promise in stem cell bioengineering
CENTRO-01-0145-FEDER-000012-N2323.
CENTRO-01-0145-FEDER-028871
 Fundação para a Ciência e a Tecnologia
2018 - 2021/02 INFERTILY2EXPLAIN: In search of novel biomarkers for unexplained human male infertility (CO-PI).
CENTRO-01-0145-FEDER-028599
 Fundação para a Ciência e a Tecnologia
2017 - 2020/03/31 LifeSciences byCENTRO.
CENTRO-01-0246-FEDER-00001
Investigador responsável
CNC.IBILI, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
2016 - 2019/09/30 Healthy Lifestyle Innovation Quarters for Cities and Citizens (HeaLIQs4Cities).
EIT-Health
Investigador
Universidade de Coimbra, Portugal
2015 - 2018/12/31 Doctoral Program in Experimental Biology and Biomedicine (PDBEB)
PD/00013/2013
Investigador responsável
CNC.IBILI, Portugal
2012 - 2015/10 The role of the pyruvate dehydrogenase kinase as a metabolic switch in pluripotency: insights into cancer and stem cell biology
PTDC/QUI-BIQ/120652/2010
 FCT - Fundação para a Ciência e a Tecnologia
2012 - 2015/10 Metabolic modulation as a tool to create and propagate pluripotent stem cell lines
PTDC/EBB-EBI/120634/2010
 Fundação para a Ciência e a Tecnologia, I.P. & COMPETE 2020
2010 - 2014/10 Metabolism as a modulator of stem cell pluripotency and differentiation
PTDC/EBB-EBI/101114/2008
 FCT - Fundação para a Ciência e a Tecnologia
2010 - 2013 Skinengineering
PTDC/SAU-OSM/099422/2008
 Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2017 - 2021 Merck Oncofertility Project
Merck 003/2017
Investigador
Laboratoires Merck Sharp et Dohme-Chibret Centre de recherche
2017 - 2020/12/31 Testing of spermicidal formulations
NA
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Produções

Publicações

Artigo em revista
  1. Mireia Alemany-Pagès; Rui Tavares; Sara Varela Amaral; Ana Teresa Barros-Viegas; Paulo J. Oliveira; João Ramalho-Santos; Anabela Marisa Azul. "Publicly stressing the role of mitochondria in NAFLD with(in) a sports event". European Journal of Clinical Investigation (2020): https://doi.org/10.1111/eci.13234.
    10.1111/eci.13234
  2. Correia, B.; Sousa, M.I.; Ramalho-Santos, J.. "The mTOR pathway in reproduction: from gonadal function to developmental coordination". Reproduction (Cambridge, England) 159 4 (2020): R173-R188. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079358628&partnerID=MN8TOARS.
    10.1530/REP-19-0057
  3. Rodrigues, A.S.; Pereira, S.L.; Ramalho-Santos, J.. "Stem metabolism: Insights from oncometabolism and vice versa". Biochimica et Biophysica Acta - Molecular Basis of Disease 1866 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082398137&partnerID=MN8TOARS.
    10.1016/j.bbadis.2020.165760
  4. Sousa, M.I.; Correia, B.; Rodrigues, A.S.; Ramalho-Santos, J.. "Metabolic characterization of a paused-like pluripotent state". Biochimica et Biophysica Acta - General Subjects 1864 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082759231&partnerID=MN8TOARS.
    10.1016/j.bbagen.2020.129612
  5. Alemany-Pagès, M.; Moura-Ramos, M.; Araújo, S.; MacEdo, M.P.; Ribeiro, R.T.; Do Ó, D.; Ramalho-Santos, J.; Azul, A.M.. "Insights from qualitative research on NAFLD awareness with a cohort of T2DM patients: Time to go public with insulin resistance?". BMC Public Health 20 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088352232&partnerID=MN8TOARS.
    10.1186/s12889-020-09249-5
  6. Soares, M.; Sousa, A.P.; Fernandes, R.; Ferreira, A.F.; Almeida-Santos, T.; Ramalho-Santos, J.. "Aging-related mitochondrial alterations in bovine oocytes". Theriogenology 157 (2020): 218-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-85089375099&partnerID=MN8TOARS.
    10.1016/j.theriogenology.2020.07.036
  7. Adriana Fontes; Mireia Alemany-Pagès; Paulo J. Oliveira; João Ramalho-Santos; Hans Zischka; Anabela Marisa Azul. "Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease". International Journal of Molecular Sciences 20 16 (2019): 3987-3987. https://doi.org/10.3390/ijms20163987.
    10.3390/ijms20163987
  8. Marzano, G.; Chiriacò, M.S.; Primiceri, E.; Dell'Aquila, M.E.; Ramalho-Santos, J.; Zara, V.; Ferramosca, A.; Maruccio, G.. "Sperm selection in assisted reproduction: A review of established methods and cutting-edge possibilities". Biotechnology Advances (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076859581&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2019.107498
  9. Tavares, R.S.; Escada-Rebelo, S.; Sousa, M.I.; Silva, A.; Ramalho-Santos, J.; Amaral, S.. "Can antidiabetic drugs improve male reproductive (Dys)function associated with diabetes?". Current Medicinal Chemistry 26 22 (2019): 4191-4222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073177859&partnerID=MN8TOARS.
    10.2174/0929867325666181101111404
  10. Tavares, R.S.; Escada-Rebelo, S.; Silva, A.F.; Sousa, M.I.; Ramalho-Santos, J.; Amaral, S.. "Antidiabetic therapies and male reproductive function: where do we stand?". Reproduction 155 1 (2018): R13-R37. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041534439&partnerID=MN8TOARS.
    10.1530/REP-17-0390
  11. Perestrelo, T.; Correia, M.; Ramalho-Santos, J.; Wirtz, D.. "Metabolic and Mechanical Cues Regulating Pluripotent Stem Cell Fate". Trends in Cell Biology 28 12 (2018): 1014-1029. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055097062&partnerID=MN8TOARS.
    10.1016/j.tcb.2018.09.005
  12. Silva, A.F.; Escada-Rebelo, S.; Amaral, S.; Tavares, R.S.; Schlatt, S.; Ramalho-Santos, J.; Mota, P.C.. "Can we induce spermatogenesis in the domestic cat using an in vitro tissue culture approach?". PLoS ONE 13 2 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041519878&partnerID=MN8TOARS.
    10.1371/journal.pone.0191912
  13. Ramalho-Santos, J.. "Data". Nature 555 7696 (2018): 408-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044176678&partnerID=MN8TOARS.
    10.1038/d41586-018-03054-2
  14. Correia, M.; Perestrelo, T.; Rodrigues, A.S.; Ribeiro, M.F.; Pereira, S.L.; Sousa, M.I.; Ramalho-Santos, J.. "Sirtuins in metabolism, stemness and differentiation". Biochimica et Biophysica Acta - General Subjects 1861 1 (2017): 3444-3455. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994527404&partnerID=MN8TOARS.
    10.1016/j.bbagen.2016.09.008
  15. Tavares, R.S.; Martins, S.; Almeida-Santos, T.; Sousa, A.P.; Ramalho-Santos, J.; da Cruz E Silva, O.A.. "Alzheimer’s disease-related amyloid-ß1–42 peptide induces the loss of human sperm function". Cell and Tissue Research (2017): 1-5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026841709&partnerID=MN8TOARS.
    10.1007/s00441-017-2665-1
  16. Tavares, R.S.; Portela, J.M.D.; Sousa, M.I.; Mota, P.C.; Ramalho-Santos, J.; Amaral, S.. "High glucose levels affect spermatogenesis: An in vitro approach". Reproduction, Fertility and Development 29 7 (2017): 1369-1378. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021107012&partnerID=MN8TOARS.
    10.1071/RD15475
  17. Perestrelo, T.; Chen, W.; Correia, M.; Le, C.; Pereira, S.; Rodrigues, A.S.; Sousa, M.I.; Ramalho-Santos, J.; Wirtz, D.. "Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software". Stem Cell Reports 9 2 (2017): 697-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-85023606018&partnerID=MN8TOARS.
    10.1016/j.stemcr.2017.06.006
  18. Marcelo Correia; Ana S. Rodrigues; Tânia Perestrelo; Sandro L. Pereira; Marcelo F. Ribeiro; Maria I. Sousa; João Ramalho-Santos. "Different concentrations of kaempferol distinctly modulate murine embryonic stem cell function". Food and Chemical Toxicology 87 (2016): 148-156. https://doi.org/10.1016%2Fj.fct.2015.12.011.
    10.1016/j.fct.2015.12.011
  19. Correia, M.; Sousa, M.I.; Rodrigues, A.S.; Perestrelo, T.; Pereira, S.L.; Ribeiro, M.F.; Ramalho-Santos, J.. "Data on the potential impact of food supplements on the growth of mouse embryonic stem cells". Data in Brief 7 (2016): 1190-1195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962815830&partnerID=MN8TOARS.
    10.1016/j.dib.2016.03.098
  20. Tavares, R.S.; Escada-Rebelo, S.; Correia, M.; Mota, P.C.; Ramalho-Santos, J.. "The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm". Reproduction 151 1 (2016): R1-R13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958255751&partnerID=MN8TOARS.
    10.1530/REP-15-0355
  21. Crespo, Â.C.; van der Zwan, A.; Ramalho-Santos, J.; Strominger, J.L.; Tilburgs, T.. "Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections". Journal of Reproductive Immunology (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84981737282&partnerID=MN8TOARS.
    10.1016/j.jri.2016.08.001
  22. Amaral, S.; Tavares, R.S.; Baptista, M.; Sousa, M.I.; Silva, A.; Escada-Rebelo, S.; Paiva, C.P.; Ramalho-Santos, J.. "Mitochondrial functionality and chemical compound action on sperm function". Current Medicinal Chemistry 23 31 (2016): 3575-3606. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996565501&partnerID=MN8TOARS.
    10.2174/0929867323666160425113518
  23. Escada-Rebelo, S.; Silva, A.F.; Amaral, S.; Tavares, R.S.; Paiva, C.; Schlatt, S.; Ramalho-Santos, J.; Mota, P.C.. "Spermatogonial stem cell organization in felid testis as revealed by Dolichos biflorus lectin". Andrology (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84977654874&partnerID=MN8TOARS.
    10.1111/andr.12223
  24. Rodrigues, A.S.; Correia, M.; Gomes, A.; Pereira, S.L.; Perestrelo, T.; Sousa, M.I.; Ramalho-Santos, J.. "Dichloroacetate, the pyruvate dehydrogenase complex and the modulation of mESC pluripotency". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940434831&partnerID=MN8TOARS.
    10.1371/journal.pone.0131663
  25. Portela, J.M.D.; Tavares, R.S.; Mota, P.C.; Ramalho-Santos, J.; Amaral, S.. "High glucose concentrations per se do not adversely affect human sperm function in vitro". Reproduction 150 1 (2015): 77-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936772520&partnerID=MN8TOARS.
    10.1530/REP-15-0100
  26. Sousa, M.I.; Rodrigues, A.S.; Pereira, S.; Perestrelo, T.; Correia, M.; Ramalho-Santos, J.. "Mitochondrial Mechanisms of Metabolic Reprogramming in Proliferating Cells". Current Medicinal Chemistry 22 20 (2015): 2493-2504. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938575415&partnerID=MN8TOARS.
  27. Fonseca, N.A.; Rodrigues, A.S.; Rodrigues-Santos, P.; Alves, V.; Gregório, A.C.; Valério-Fernandes, Â.; Gomes-da-Silva, L.C.; et al. "Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination". Biomaterials 69 (2015): 76-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940734367&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2015.08.007
  28. Paiva, C.; Amaral, A.; Rodriguez, M.; Canyellas, N.; Correig, X.; Ballescà, J.L.; Ramalho-Santos, J.; Oliva, R.. "Identification of endogenous metabolites in human sperm cells using proton nuclear magnetic resonance (1H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS)". Andrology 3 3 (2015): 496-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929839766&partnerID=MN8TOARS.
    10.1111/andr.12027
  29. Tavares, R.S.; Amaral, S.; Paiva, C.; Baptista, M.; Ramalho-Santos, J.. "In vitro exposure to the organochlorine p,p'-DDE affects functional human sperm parameters". Chemosphere 120 (2015): 443-446. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912104888&partnerID=MN8TOARS.
    10.1016/j.chemosphere.2014.08.075
  30. Rodrigues, A.S.; Pereira, S.L.; Correia, M.; Gomes, A.; Perestrelo, T.; Ramalho-Santos, J.. "Differentiate or die: 3-Bromopyruvate and pluripotency in mouse embryonic stem cells". PLoS ONE 10 8 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84942843640&partnerID=MN8TOARS.
    10.1371/journal.pone.0135617
  31. Cordeiro, M.H.; Kim, S.-Y.; Ebbert, K.; Duncan, F.E.; Ramalho-Santos, J.; Woodruff, T.K.. "Geography of follicle formation in the embryonic mouse ovary impacts activation pattern during the first wave of folliculogenesis". Biology of Reproduction 93 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84947290970&partnerID=MN8TOARS.
    10.1095/biolreprod.115.131227
  32. Amaral, S.V.; Forte, T.; Ramalho-Santos, J.; Da Cruz, M.T.G.. "I want more and better cells! - An outreach project about stem cells and its impact on the general population". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84941929963&partnerID=MN8TOARS.
    10.1371/journal.pone.0133753
  33. Amaral, A.; Castillo, J.; Ramalho-Santos, J.; Oliva, R.. "The combined human sperm proteome: Cellular pathways and implications for basic and clinical science". Human Reproduction Update 20 1 (2014): 40-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889633604&partnerID=MN8TOARS.
    10.1093/humupd/dmt046
  34. Lourenço, B.; Sousa, A.P.; Almeida-Santos, T.; Ramalho-Santos, J.. "Relation of cumulus cell status with single oocyte maturity, fertilization capability and patient age". Journal of Reproduction and Infertility 15 1 (2014): 15-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895893874&partnerID=MN8TOARS.
  35. Ramalho-Santos, J.. "Sins of the fathers: Sperm DNA damage in the context of assisted reproduction". Human Reproduction 29 11 (2014): 2356-2358. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913586642&partnerID=MN8TOARS.
    10.1093/humrep/deu229
  36. Amaral, A.; Paiva, C.; Attardo Parrinello, C.; Estanyol, J.M.; Ballescà, J.L.; Ramalho-Santos, J.; Oliva, R.. "Identification of proteins involved in human sperm motility using high-throughput differential proteomics". Journal of Proteome Research 13 12 (2014): 5670-5684. http://www.scopus.com/inward/record.url?eid=2-s2.0-84915748593&partnerID=MN8TOARS.
    10.1021/pr500652y
  37. Marques, M.; Sousa, A.P.; Paiva, A.; Almeida-Santos, T.; Ramalho-Santos, J.. "Low amounts of mitochondrial reactive oxygen species define human sperm quality". Reproduction 147 6 (2014): 817-824. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660651&partnerID=MN8TOARS.
    10.1530/REP-13-0644
  38. Ramalho-Santos, J.. "Emancipation". Nature 510 7505 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84902971393&partnerID=MN8TOARS.
    10.1038/510436a
  39. Pereira, S.L.; Rodrigues, A.S.; Sousa, M.I.; Correia, M.; Perestrelo, T.; Ramalho-Santos, J.. "From gametogenesis and stem cells to cancer: Common metabolic themes". Human Reproduction Update 20 6 (2014): 924-943. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913602111&partnerID=MN8TOARS.
    10.1093/humupd/dmu034
  40. Sousa, M.I.; Amaral, S.; Tavares, R.S.; Paiva, C.; Ramalho-Santos, J.. "Concentration-dependent Sildenafil citrate (Viagra) effects on ROS production, energy status, and human sperm function". Systems Biology in Reproductive Medicine 60 2 (2014): 72-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901672805&partnerID=MN8TOARS.
    10.3109/19396368.2013.867380
  41. Baptista, M.; Tavares, R.; Ramalho-Santos, J.. "Spermicidal and microbicidal compounds: In search of an efficient multipurpose strategy". Current Medicinal Chemistry 21 32 (2014): 3693-3700. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929093972&partnerID=MN8TOARS.
  42. Baptista, M.; Publicover, S.J.; Ramalho-Santos, J.. "In vitro effects of cationic compounds on functional human sperm parameters". Fertility and Sterility 99 3 (2013): 705-712. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875230252&partnerID=MN8TOARS.
    10.1016/j.fertnstert.2012.11.008
  43. Pereira, S.L.; Grãos, M.; Rodrigues, A.S.; Anjo, S.I.; Carvalho, R.A.; Oliveira, P.J.; Arenas, E.; Ramalho-Santos, J.. "Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891590984&partnerID=MN8TOARS.
    10.1371/journal.pone.0082095
  44. Carvalho, A.S.; Ramalho-Santos, J.. "How can ethics relate to science? The case of stem cell research.". European journal of human genetics : EJHG 21 6 (2013): 591-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885931079&partnerID=MN8TOARS.
    10.1038/ejhg.2012.232
  45. Amaral, A.; Castillo, J.; Estanyol, J.M.; Ballesca, J.L.; Ramalho-Santos, J.; Oliva, R.. "Human sperm tail proteome suggests new endogenous metabolic pathways". Molecular and Cellular Proteomics 12 2 (2013): 330-342. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874070103&partnerID=MN8TOARS.
    10.1074/mcp.M112.020552
  46. Pereira, S.P.; Pereira, G.C.; Pereira, C.V.; Carvalho, F.S.; Cordeiro, M.H.; Mota, P.C.; Ramalho-Santos, J.; Moreno, A.J.; Oliveira, P.J.. "Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats". Environmental Pollution 180 (2013): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879443261&partnerID=MN8TOARS.
    10.1016/j.envpol.2013.05.049
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    10.1016/S0015-0282(01)02957-0
  110. Moreno, R.D.; Schatten, G.; Ramalho-Santos, J.. "Golgi apparatus dynamics during mouse oocyte in vitro maturation: Effect of the membrane trafficking inhibitor brefeldin A". Biology of Reproduction 66 5 (2002): 1259-1266. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036240029&partnerID=MN8TOARS.
  111. Cooper, T.G.; Yeung, C.-H.; Jones, R.; Orgein-Crist, M.-C.; Robaire, B.; Sutovsky, P.; Moreno, R.D.; et al. "Rebuttal of a role for the epididymis in sperm quality control by phagocytosis of defective sperm (multiple letters)". Journal of Cell Science 115 1 (2002): 5-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036153319&partnerID=MN8TOARS.
  112. Ramalho-Santos, J.; Schatten, G.; Moreno, R.D.. "Control of membrane fusion during spermiogenesis and the acrosome reaction". Biology of Reproduction 67 4 (2002): 1043-1051. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036786058&partnerID=MN8TOARS.
  113. RamalhoSantos, João. "Fluorescent probes for monitoring virus fusion kinetics: comparative evaluation of reliability". (2002):
    10.1016/s0005-2736(01)00457-6
  114. Nunes-Correia, I.; Eulálio, A.; Nir, S.; Düzgünes, N.; Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Fluorescent probes for monitoring virus fusion kinetics: Comparative evaluation of reliability". Biochimica et Biophysica Acta - Biomembranes 1561 1 (2002): 65-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037133738&partnerID=MN8TOARS.
    10.1016/S0005-2736(01)00457-6
  115. Ramalho-Santos, J.; Moreno, R.D.; Wessel, G.M.; Chan, E.K.L.; Schatten, G.. "Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis". Experimental Cell Research 267 1 (2001): 45-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035398602&partnerID=MN8TOARS.
    10.1006/excr.2000.5119
  116. Ramalho-Santos, J.; Moreno, R.D.. "Targeting and fusion proteins during mammalian spermiogenesis". Biological Research 34 2 (2001): 147-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034785031&partnerID=MN8TOARS.
  117. Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Fusion and infection of influenza and sendai viruses as modulated by dextran sulfate: A comparative study". Bioscience Reports 21 3 (2001): 293-304. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035721635&partnerID=MN8TOARS.
    10.1023/A:1013282015121
  118. Sutovsky, P.; Moreno, R.; Ramalho-Santos, J.; Dominko, T.; Thompson, W.E.; Schatten, G.. "A putative, ubiquitin-dependent mechanism for the recognition and elimination of defective spermatozoa in the mammalian epididymis". Journal of Cell Science 114 9 (2001): 1665-1675. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035012044&partnerID=MN8TOARS.
  119. RamalhoSantos, João. "Acrosome components after intracytoplasmic sperm injection: the decondensation frontier". (2001):
    10.1016/s0015-0282(01)01835-0
  120. Ramalho-Santos, J.; Simerly, C.R.; Hewitson, L.; Schatten, G.. "Acrosome components after intracytoplasmic sperm injection: The decondensation frontier". Fertility and Sterility 76 1 (2001): 196-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034957422&partnerID=MN8TOARS.
    10.1016/S0015-0282(01)01835-0
  121. Chan, A.W.S.; Luetjens, C.M.; Dominko, T.; Ramalho-Santos, J.; Simerly, C.R.; Hewitson, L.; Schatten, G.. "Foreign DNA transmission by ICSI: Injection of spermatozoa bound with exogenous DNA results in embryonic GFP expression and live rhesus monkey births". Molecular Human Reproduction 6 1 (2000): 26-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033982494&partnerID=MN8TOARS.
  122. Ramalho-Santos, J.; Sutovsky, P.; Simerly, C.; Oko, R.; Wessel, G.M.; Hewitson, L.; Schatten, G.. "ICSI choreography: Fate of sperm structures after monospermic rhesus ICSI and first cell cycle implications". Human Reproduction 15 12 (2000): 2610-2620. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034534984&partnerID=MN8TOARS.
  123. Moreno, R.D.; Ramalho-Santos, J.; Sutovsky, P.; Chan, E.K.L.; Schatten, G.. "Vesicular traffic and Golgi apparatus dynamics during mammalian spermatogenesis: Implications for acrosome architecture". Biology of Reproduction 63 1 (2000): 89-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033944267&partnerID=MN8TOARS.
  124. Chan, A.W.S.; Luetjens, C.M.; Dominko, T.; Ramalho-Santos, J.; Simerly, C.R.; Hewitson, L.; Schatten, G.. "TransgenICSI reviewed: Foreign DNA transmission by intracytoplasmic sperm injection in rhesus monkey". Molecular Reproduction and Development 56 2 SUPPL. (2000): 325-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034026568&partnerID=MN8TOARS.
  125. Sutovsky, P.; Moreno, R.D.; Ramalho-Santos, J.; Dominko, T.; Simerly, C.; Schatten, G.. "Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos". Biology of Reproduction 63 2 (2000): 582-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033883489&partnerID=MN8TOARS.
  126. Ramalho-Santos, J.; Moreno, R.D.; Sutovsky, P.; Chan, A.W.-S.; Hewitson, L.; Wessel, G.M.; Simerly, C.R.; Schatten, G.. "SNAREs in mammalian sperm: Possible implications for fertilization". Developmental Biology 223 1 (2000): 54-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034235393&partnerID=MN8TOARS.
    10.1006/dbio.2000.9745
  127. Moreno, R.D.; Ramalho-Santos, J.; Chan, E.K.L.; Wessel, G.M.; Schatten, G.. "The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: Structural alterations". Developmental Biology 219 2 (2000): 334-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034643141&partnerID=MN8TOARS.
    10.1006/dbio.2000.9606
  128. Sutovsky, P.; Moreno, R.D.; Ramalho-Santos, J.; Dominko, T.; Simerly, C.; Schatten, G.. "Ubiquitin tag for sperm mitochondria". Nature 402 6760 (1999): 371-372. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033604547&partnerID=MN8TOARS.
    10.1038/46466
  129. Hewitson, L.; Dominko, T.; Takahashi, D.; Martinovich, C.; Ramalho-Santos, J.; Sutovsky, P.; Fanton, J.; et al. "Unique checkpoints during the first cell cycle of fertilization after intracytoplasmic sperm injection in rhesus monkeys". Nature Medicine 5 4 (1999): 431-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032957381&partnerID=MN8TOARS.
    10.1038/7430
  130. Dominko, T.; Ramalho-Santos, J.; Chan, A.; Moreno, R.D.; Luetjens, C.M.; Simerly, C.; Hewitson, L.; et al. "Optimization strategies for production of mammalian embryos by nuclear transfer". Cloning and Stem Cells 1 3 (1999): 143-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-0012759017&partnerID=MN8TOARS.
  131. Nunes-Correia, I.; Ramalho-Santos, J.; Nir, S.; Pedroso De Lima, M.C.. "Interactions of influenza virus with cultured cells: Detailed kinetic modeling of binding and endocytosis". Biochemistry 38 3 (1999): 1095-1101. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033579938&partnerID=MN8TOARS.
    10.1021/bi9812524
  132. Sutovsky, P.; Ramalho-Santos, J.; Moreno, R.D.; Oko, R.; Hewitson, L.; Schatten, G.. "On-stage selection of single round spermatids using a vital, mitochondrion-specific fluorescent probe MitoTracker(TM) and high resolution differential interference contrast microscopy". Human Reproduction 14 9 (1999): 2301-2312. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032850898&partnerID=MN8TOARS.
    10.1093/humrep/14.9.2301
  133. RamalhoSantos, João; Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Role of a transbilayer pH gradient in the membrane fusion activity of the influenza virus hemagglutinin: Use of the R18 assay to monitor membrane merging". Biological Procedures Online 1 3 (1999): 107-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750619807&partnerID=MN8TOARS.
    10.1251/bpo13
  134. Nunes-Correia, I.; Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Sendai virus fusion activity as modulated by target membrane components". Bioscience Reports 18 2 (1998): 59-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031727161&partnerID=MN8TOARS.
    10.1023/A:1020180109275
  135. Ramalho-Santos, J.; De Lima, M.C.P.; Almeida, M.T.; De Pedroso Lima, M.C.. "The influenza virus hemagglutinin: A model protein in the study of membrane fusion". Biochimica et Biophysica Acta - Reviews on Biomembranes 1376 1 (1998): 147-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032578032&partnerID=MN8TOARS.
    10.1016/S0304-4157(98)00002-1
  136. Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Fusion activity of the influenza virus hemagglutinin does not require a transbilayer pH gradient". Biochimica et Biophysica Acta - Biomembranes 1330 2 (1997): 194-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030778514&partnerID=MN8TOARS.
    10.1016/S0005-2736(97)00166-1
  137. Almeida, M.T.; Ramalho-Santos, J.; Oliveira, C.R.; Pedroso De Lima, M.C.. "Evidence that synaptobrevin is involved in fusion between synaptic vesicles and synaptic plasma membrane vesicles". Biochemical and Biophysical Research Communications 236 1 (1997): 184-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031561140&partnerID=MN8TOARS.
    10.1006/bbrc.1997.6928
  138. Ramalho-Santos, J.; De Pedroso Lima, M.C.; Nir, S.. "Partial fusion activity of influenza virus toward liposomes and erythrocyte ghosts is distinct from viral inactivation". Journal of Biological Chemistry 271 39 (1996): 23902-23906. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029842067&partnerID=MN8TOARS.
    10.1074/jbc.271.39.23902
  139. Bernardes, C.; Valdeira, M.L.; Ramalho-Santos, J.; De Lima, M.C.P.. "Fusion activity of African swine fever virus towards target membranes: Lipid dependence and effect of dehydrating agents". Biochemistry and Molecular Biology International 37 3 (1995): 481-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029555561&partnerID=MN8TOARS.
  140. Pedroso de Lima, M.C.; Ramalho-Santos, J.; Flasher, D.; Slepushkin, V.A.; Nir, S.; Düzgunes, N.. "Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus". BBA - Biomembranes 1236 2 (1995): 323-330. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029026187&partnerID=MN8TOARS.
    10.1016/0005-2736(95)00067-D
  141. Almeida, M.T.; Ramalho-Santos, J.; Oliveira, C.R.; Pedroso de Lima, M.C.. "Parameters affecting fusion between liposomes and synaptosomes. Role of proteins, lipid peroxidation, pH and temperature". The Journal of Membrane Biology 142 2 (1994): 217-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027993101&partnerID=MN8TOARS.
    10.1007/BF00234943
  142. Ramalho-Santos, J.; Negrão, R.; Lima, M.d.C.P.d.. "Role of hydrophobic interactions in the fusion activity of influenza and sendai viruses towards model membranes". Bioscience Reports 14 1 (1994): 15-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028243606&partnerID=MN8TOARS.
    10.1007/BF01901634
  143. Ramalho-Santos, J.; Negrao, R.; Da Conceicao Pedroso de Lima, M.. "Fusion of Sendai virus with model membranes as affected by dehydrating agents and pH: Correlation between viral envelope hydrophobicity and fusion activity". Biochemistry and Molecular Biology International 32 6 (1994): 1121-1127. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028352917&partnerID=MN8TOARS.
  144. Ramalho-Santos, J.; Nir, S.; Düzgünes, N.; De Carvalho, A.P.; De Lima, M.D.C.P.. "A common mechanism for influenza virus fusion activity and inactivation". Biochemistry 32 11 (1993): 2771-2779. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027417786&partnerID=MN8TOARS.
    10.1021/bi00062a006
  145. PEDROSO DE LIMA, Maria da Conceicao; RAMALHO-SANTOS, Joao; MARTINS, Maria de Fatima; PATO DE CARVALHO, Arselio; BAIROS, Vasco; NIR, Shlomo. "Kinetic modeling of Sendai virus fusion with PC-12 cells. Effect of pH and temperature on fusion and viral inactivation". European Journal of Biochemistry 205 1 (1992): 181-186. http://dx.doi.org/10.1111/j.1432-1033.1992.tb16766.x.
    10.1111/j.1432-1033.1992.tb16766.x
  146. Seppen, J.; Ramalho-Santos, J.; de Carvalho, A.P.; ter Beest, M.; Kok, J.W.; Pedroso de Lima, M.C.; Hoekstra, D.. "Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration". BBA - Biomembranes 1106 1 (1992): 209-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026587918&partnerID=MN8TOARS.
    10.1016/0005-2736(92)90240-M
Capítulo de livro
  1. Azul, A.M.; Ramalho-Santos, J.; Oliveira, P.J.; Tavares, R.. "Mitochondrial follies: A short journey in life and energy". 649-692. 2018.
  2. Amaral, S.; Tavares, R.S.; Escada-Rebelo, S.; Silva, A.F.; Ramalho-Santos, J.. "Mammalian Sperm Mitochondrial Function as Affected by Environmental Toxicants, Substances of Abuse, and Other Chemical Compounds". 185-203. 2018.
  3. Ramalho-Santos, J.; Tavares, R.S.. "Endocrine disruptors and male reproductive function". 629-633. 2018.
  4. Palmeira, C.M.; Ramalho-Santos, J.. "Mitochondrial dysfunction in reproductive and developmental toxicity". 1023-1035. 2017.
Livro
  1. João Ramalho-Santos; Rui Tavares. As Luzes do Príncipe. Sobre as experiências realizadas na Ilha do Príncipe em 1919, que ajudaram a validar a Teoria da Relatividade Geral. 2019.
    10.14195/978-989-26-1831-9
  2. Amaral, S.; Ramalho-Santos, J.. Free radical biology and reproductive health in diabetes. 2012.
    10.1007/978-3-642-30018-9_115
  3. Palmeira, C.M.; Ramalho-Santos, J.. Mitochondrial Dysfunction in Reproductive and Developmental toxicity. 2011.
    10.1016/B978-0-12-382032-7.10061-X
  4. Amaral, A.; Sousa, A.P.; Campo, P.C.; Peregrín, P.C.; Ramalho-Santos, J.. Bioenergetics and male infertility: From basic science to clinical andrology. 2011.

Outros

Outra produção
  1. Ramalho-Santos, João; Rodrigues, Ana Sofia. 2013. From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) a Mitochondrial Odyssey. Mitochondrial DNA, Mitochondria, Disease and Stem Cells. http://dx.doi.org/10.1007/978-1-62703-101-1_4.
    10.1007/978-1-62703-101-1_4
  2. Gamboa S; Francisco M; Gomes P; Mendes C; Machado-Faria M; Ramalho-Santos J. 2011. Level of Glycolyzable Substrates in Stallion Semen: Effect of Ejaculation Frequency on Sperm Survival after Cool Storage during the Nonbreeding Season. http://europepmc.org/abstract/AGR/IND44569660.
    10.1016/j.jevs.2010.12.011
  3. Pedroso de Lima, Maria C.; Ramalho-Santos, João; Düzgünes, Nejat; Flasher, Diana; Nir, Shlomo. 1995. Entry of Enveloped Viruses Into Host Cells: Fusion Activity of the Influenza Virus Hemagglutinin. Trafficking of Intracellular Membranes:. http://dx.doi.org/10.1007/978-3-642-79547-3_8.
    10.1007/978-3-642-79547-3_8
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019 Stem Cells and Cell Therapies: From Bench to Bedside. 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies.
(Lisbon, Portugal)
2019 Assisted Reproduction: From Basics, to Biotechnology, to Bioethics. IMM PostDoc Meeting
IMM (Portugal)
2019 Infertility and Assisted Reproduction: From Biotechnology to Bioethics. 10th ITQB NOVA PhD Students’ Meeting
(Portugal)
2019 Dentro da Caixa, Fora da Caixa, Sem Caixas: Alguns desafios em abordar a Biologia das Coisas Departamento de História e Filosofia das Ciências, Universidade de Lisboa
2019 Para além da Biologia: Sobre as carreiras que Biólogos do futuro criarão para si próprios. Jornadas do Mar, ICBAS, Porto
2019 As Famílias do Futuro. 36ª Conferência Caminhos para a Vida
2019 Bioética para Biólogos: Porquê? XXII Encontro Nacional dos Estudantes de Biologia (ENEB), Faro
2018 From the Search of Functional Biomarkers in Human Sperm to Oncofertility Solutions: From the Lab to the Clinic . Jordan Frontiers in Stem Cells, Cancer and Reproduction, International Symposium and Workshop
Jordan Heshemite University
2018 Sperm Metabolomics. European Congress of Andrology
European Congress of Andrology (Budapest, Hungria)
2018 Metabolism in human sperm function: from biology, to translation, to communication. Symposium on the Preservation of Male Fertility
Karolinska Institutet (Suécia)
2018 You are your Biochemistry: Metabolism as a key player in Human Fertility Fertility 2018, Joint Annual Conference of the Association of Clinical Embryologists (ACE), the British Fertility Society (BFS) and the Society of Reproduction and Fertility (SRF),
Association of Clinical Embryologists (ACE), the British Fertility Society (BFS) and the Society of Reproduction and Fertility (SRF) (Liverpool, Reino Unido)
2018 Epigenetics as a Driver of Developmental Origins of Health and Disease CMIN Sumit’18- Developmental Origins of Health and Disease
2018 Metabolism-based Biomarkers in Male Reproductive Function: From Function, to Translation, to Communication. . Seminars on Biomarkers and Assay Development, Faculdade de Farmácia, Universidade de Lisboa
2017 The Multilayered Challenges of Contemporary Graduate Training in Biochemistry and Experimental Biology. Annual Meeting of the Brazilian Biochemistry Society
Brazilian Biochemistry Society (Brasil)
2017 Science, Society, Ethics, Communication: Why should YOU care? FOIE-GRAS ETN Network School: Tools and Rationale for Measuring Mitochondrial Function in Intact Cells and Isolated Mitochondria
CNC (Portugal)
2017 Metabolic Regulation of Stem Cell Pluripotency FEBS Advanced Course on Oncometabolism
(Portugal)
2017 Non-genomic effects of EDCs on sperm. International Congress of Andrology.
(Dinamarca)
2017 Mitochondrial function and Human Sperm Quality European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting
European Society of Human Reproduction and Embryology (ESHRE) (Geneva, Suiça)
2017 Non-genomic effects of Endocrine Disruptors on sperm cells. International Workshop on Endocrine Disruptors
(Copenhagen, Dinamarca)
2017 The Biology of Sex: Definitions, Paradigms, Borders, Misconceptions (and how to subvert it all) Intersexualities: Crossing Bodies, Crossing Borders International Conference
(Porto, Portugal)
2017 Da Clínica ao espermatozoide e à molécula... E regresso. 1ªs Jornadas Internacionias de Andrologia Reprodutiva, Gaia
2017 Disruptores Endócrinos e Fertilidade. 21º Congresso de Obstetrícia e Ginecologia, Coimbra
2017 Contagem (de)Crescente opara o futuro: Inovações potenciais em Procriação Medicamente Assistida. 1º Conferência do Observatório da Natalidade e Envelhecimento, Desafios da Natalidade: Infertilidade e Procriação Medicamente Assistida, ISEG, Lisboa
2017 Adventures in Reproduction and Stem Cells: From Metabolism to Ethics and Outreach. Second Annual BioSAM– Biological Sciences Annual Meeting, Faculdade de Ciências da Universidade de Lisboa. Lisboa
2017 Alteração Genética em Embriões: Da Ciência à Ética (ou vice-versa?). Jornadas de Ciências Biomédicas, Braga
2016 Probes to monitor sperm function 9th European Congress of Andrology
(Rotterdam, Países Baixos)
2016 Bioethics in the reproductive sciences. 9th Meeting of the International Network for Young Researchers in Male Fertility
(Rennes, França)
2016 Notes on stem cell pluripotency: From metabolism to ethics and outreach Stem Cell Symposium, Lisboa, Portugal
2016 Notes on Pluripotency: From metabolism to outreach. V Inter-University Doctoral Programme in Ageing and Chronic Disease (PHDOC), Meeting, Coimbra
2016 Biologia da Reprodução: Algumas notas (mais ou menos) soltas. II Ciclo de Conferências Ciências Biomédicas à Tarde, Universidade da Beira Interior, Covilhã
2016 Bioenergetic adventures in reproduction and pluripotency. AVX Seminars, ITQB, Oeiras
2016 Aventuras em reprodução, pluripotência de células estaminais e cancro. João Ramalho-Santos. IX Encontro Nacional dos Estudantes de Bioquímica (ENEBIOQ), Coimbra, P
2016 Sex-Ética: Reprodução com ética (mas sem sexo?) XIX Encontro Nacional dos Estudantes de Biologia (ENEB), Coimbra,
2016 Da Bioquímica à Biologia da Reprodução e Células Estaminais, passando pela Banda Desenhada: O percurso de um Biólogo Errante. Encontro Nacional da Ordem dos Biólogos. Évora.
2015 The challenges in the functional study of pluripotent stem cells and human sperm. REPROTRAIN International Meeting
(Barcelona, Espanha)
2015 From the acrosome to mitochondria and stem cells: Adventures in Reproduction. Frontiers in Reproduction International Symposium, Marine Biology Laboratory
(Estados Unidos)
2015 Mitochondria as regulators of fertility and pluripotency. Hubrecht Institute Seminar Series
Hubrecht Institute (Utrecht, Países Baixos)
2015 - Monitoring mitochondrial function in challenging cells: Sperm and pluripotent stem cells. 5th World Congress of Targeting Mitochondria
(Berlin, Alemanha)
2015 Os impactos éticos da Biotecnologia. Encontro de Biotecnologia- Pavilhão do Conhecimento, Ciência Viva. Lisboa.
2015 Cientistas, Clínicos, Pacientes: Que tipo de expetativas num diálogo bioético Congresso da APASD (Associação Portuguesa para a Segurança dos Doentes), Porto.
2015 Mitochondria as regulators os fertility and pluripotency. VI Jornadas De Ciências Biomédicas, Universidade do Algarve, Faro
2015 Embriões excedentários: que destinos? Jornadas da Sociedade Portuguesa de Medicina da Reprodução, Óbidos
2014 Sexually Transmitted infections and spermicides 14th Congress of the European Society for Contraception
(Lisbon, Portugal)
2014 Mitochondrial and sperm function: From cell to organelle, and back. 26th German Congress of Andrology
(Giessen, Alemanha)
2014 Profiling human sperm: From functional studies to omics analyses, and back again. European Congress of Andrology
(Barcelona, Espanha)
2014 Ageing and Reproduction: A mitochondrial perspective . 3rd World Congress on Reproduction, Oxidative Stress and Antioxidants
(Paris, França)
2014 Mitochondria as regulators of pluripotency Reproductive Biology Seminar Series, Northwestern University
(Chicago, Estados Unidos)
2014 A mitocôndria como reguladora da fertilidade e da pluripotência. VI Jornadas de Genética e Biotecnologia, Universidade do Trás os Montes e Alto Douro, Vila Real
2014 Biologia da Reprodução: Um Biólogo entre a Investigação e a Clínica As Ciências Biológicas para além da História Natural. Série de Seminários: A diversidade dos estudos em Biologia. Escola Superior Agrária, Instituto Politécnico de Coimbra.
2013 Stem Cell Pluripotency: Why Mitochondria Matter. 6th Meeting of the International Network of Young Researchers in Male Fertility
(Barcelona, Espanha)
2013 Mitochondria as Determinants of Stem Cell Differentiation 47th Annual Meeting of the European Society for Clinical Investigation
(Albufeira, Portugal)
2013 Epigenética e Fertilidade. 3º Congresso CIMAGO, Atualizações em Oncologia, Coimbra
2013 A mitocôndria como reguladora da pluripotência e diferenciação de células estaminais. VI Jornadas de Biologia, Universidade do Trás os Montes e Alto Douro, Vila Real,
2013 Células estaminais e Cancro VI Encontro Nacional dos Estudantes de Bioquímica (ENEBIOQ), Aveiro
2013 A mitocôndria como reguladora da pluripotência e diferenciação de células estaminais. XIV Jornadas de Biologia Aplicada, Universidade do Minho, Braga,
2012 Modulating sperm function for contraception: a multilayered challenge 12th Congress of the European Society for Contraception
(Athens, Grécia)
2012 Mitochondria in Reproduction & Stem Cells: Why bother? FIR Symposium, Marine Biology Laboratory
(Estados Unidos)
2012 A mitocôndria como reguladora da pluripotência e diferenciação de células estaminais. JORTEC 2012, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa,
2012 A mitocôndria como reguladora da fertilidade American Association of Pharmaceutical Scientists (AAPS)– University of Porto Student Chapter, Porto
2012 A mitocôndria como reguladora da pluripotência e diferenciação de células estaminais. V Encontro Nacional dos Estudantes de Bioquímica (ENEBIOQ), Coimbra
2012 A Biologia entre a Investigação Básica e a Investigação Clínica: A Reprodução enquanto caso de estudo XV Encontro Nacional dos Estudantes de Biologia (ENEB), Coimbra
2011 Estratégias para investigar o que não pode ser investigado TEDx Coimbra
2011 A Fisiologia do Espermatozóide: Da Biologia Celular e Bioquímica à Fisiologia . XXVIII Jornadas de Estudos da Reprodução/Sociedade Portuguesa de Medicina da Reprodução, Monte Real
2011 Mitochondria as regulators of fertility and embryonic stem cell pluripotency IV Jornadas Nacionais de Genética e Biotecnologia, Vila Real
2010 A mitocôndria como reguladora da fertilidade e pluripotência I Jornadas de Ciências Biomédicas, Aveiro
2010 Metabolism as a regulator of pluripotency Ciência 2010, Encontro com a Ciência e Tecnologia em Portugal

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018 - 2019 Analysis of the Efficacy and Safety of Benzalkonium Chloride and Myristalkonium Chloride as Active Principles for Contraceptive Purposes
Coorientador de Maria Inês Alfaiate
 Mestrado em Bioquímica (Mestrado)
Universidade de Coimbra, Portugal
2018 - 2019 Evaluation of ageing-related molecular and bioenergetic alterations in bovine oocytes
Coorientador de Maria Moreira Soares
 Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2017 - 2019 Técnicas de data mining aplicadas ao varicocele
Coorientador de Judith Santos Pereira
 Mestrado em Engenharia Informática e Sistemas (Mestrado)
Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2017 - 2018 Quiet, they may be at rest: Molecular Mechanisms of paused pluripotency
Coorientador de Bibiana Correia Silva
 Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2017 - 2018 Comparação de parâmetros mitocondriais entre ovócitos jovens e envelhecidos
Coorientador de Raquel Direito Fernandes
 Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2017 - 2018 Estimulação angiogénica de tecido ovárico criopreservado
Coorientador de Maria Carolina Pereira Reis
 Mestrado em Bioquímica (Mestrado)
Universidade de Coimbra, Portugal
2017 - 2017 Edible mushrooms as mediators of sustainability and human health Biodiversidade e Biotecnologia Vegetal (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2017 Framing pluripotency: From gene to image
Orientador
 Cell, Molecular and Developmental Biology (Doutoramento)
Universidade de Coimbra, Portugal
2012 - 2016 Mechanisms underlying metabolic shift in pluripotent stem cells
Orientador
 Cell, Molecular and Developmeent Biology (Doutoramento)
Universidade de Coimbra, Portugal
2015 - 2015 Mechanisms and possible function of SIRT3 in mESC
Orientador
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2015 Desafios na Inovação da Comunicação de Ciência em Portugal
Coorientador
 Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2015 Characterization of KIR2DS1+ decidual Natural Killer cells in healthy and viral/bacterial – infected human pregnancy
Coorientador
 Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2015 Human sperm motility: Proteins and metabolites towards the same journey’s end
Coorientador
 Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra, Portugal
2014 - 2014 Preservação da fertilidade: maturação in vitro de oócitos pré ou pós vitrificação Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014 A cat problem: Characterization of feline spermatogonial stem cells Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014 Insights into the reproductive dysfunction in diabetes: an in vitro approach
Coorientador
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2014 Generation of a VASA/GDF-9/ZP3-promoter driven triple transgenic reporter mouse line as a tool to study ovarian dynamics
Coorientador
 Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2014 Mechanisms of induced pluripotency: The role of the Nucleosome Remodelling and Deacetylase complex
Coorientador
 Biologia Experimental e Biomedicina
Universidade de Coimbra, Portugal
2009 - 2014 Unraveling the Mechanisms of Spermicidal Activity by Surfactants:Their Potential Use as Safe Multi-Functional Compounds
Orientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2014 A Two-Sided Tale: The Influences of Environmental Endocrine Disruptors and Sperm Chromatin Status on Male Fertility
Orientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2014 The role of metabolism and mitochondrial function in embryonic stem cells
Orientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2013 MODULAÇÃO METABÓLICA EM PROCESSOS DE REPROGRAMAÇÃO CELULAR
Orientador
 Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2013 Estudo de subpopulações de espermatozóides com base no conteúdo em espécies reativas de oxigénio mitocondriais Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2013 Metabolismo e diferenciação de células estaminais
Coorientador
 Cell Biology
Universidade de Coimbra, Portugal
2006 - 2011 Infertilidade Equina: Múltiplas Fragilidades ou um "Fado" do Espermatozóide
Orientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2010 The domestic cat as a model for endangered felids: From isolated mitochondria as a screening tool, to testis tissue xenografting for fertility recovery
Orientador
Universidade de Coimbra, Portugal
2005 - 2010 Functional Characterisation of the Human Sperm: Implications for Fertility
Orientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2009 A Problemática da Diabetes na Fertilidade Masculina: Meandros Histológicos, Bioquímicos e Moleculares
Orientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2009 Linking Open Chromatin to Pluripotency in es Cells. the Role of the Chromatin Rewmodeler Chd1
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2009 Mitochondria Modulate Pluripotency in Human Embryonic Stem Cells
Orientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003 - 2009 Human Sperm Mitochondrial Function: Implications for Male (in)fertility
Orientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003 - 2007 Regulation of Apoptosis and Differentiation by P53 in Human Embryonic Stem Cells
Coorientador
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018/05/05 - 2018/05/15 The 20th Europen Testis Workshop (ETW), Óbidos, Portugal. (2018/05/05 - 2018/05/15)
Congresso (Presidente da Comissão Organizadora)

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019 Andrology & Assisted Reproduction
Arguente principal
 Marc Torrà (Doutoramento)
Hospital Clínic de Barcelona, Espanha

Universitat de Barcelona Departament de Medicina, Espanha
2018 Stem cell differentiation
Arguente principal
 Elsa Sousa (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 Stem cell differentiation
Arguente principal
 Teresa Silva (Doutoramento)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2018 Testis Organoids
Arguente principal
 João Pedro Alves-Lopes (Doutoramento)
Karolinska Institutet, Suécia
2017 Sperm physiology and Endocrine disruptors
Arguente principal
 Anders Rehfeld. (Doutoramento)
University of Copenhagen Biotech Research and Innovation Centre, Dinamarca
2015 Stem cell differentiation
Arguente principal
 Ana Freire (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 stem cell differentiation
Arguente principal
 Joana Xavier (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 Bioethics of cloning
Arguente
 Carlos Pereira (Doutoramento)
Universidade Católica Portuguesa, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019 - Atual Fertility and Sterility- Science
2019 - Atual International Journal of Molecular Sciences (1422-0067) MDPI AG
2013 - Atual Reproduction (1741-7899) Bioscientifica
2012 - 2017 Human Reproduction
2007 - 2010 Human Reproduction Update
2003 - 2006 Human Reproduction (1460-2350) Oxford University Press
Distinções

Prémio

2020 Prémio Santander-UC de Inovação Pedagógica
Universidade de Coimbra, Portugal
2018 Prémio Mocho/Genes d’Ouro, Melhor Professor da Licenciatura em Biologia
2016 Prémio Jornal “As Beiras”, Investigação/Ciência
2015 Fronteirs in Reproduction Alumni Award