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Mariana is a research fellow at the Research Institute for Medicines (iMed) of the Faculty of Pharmacy, Universidade de Lisboa. She completed her Master degree in Biological and Chemical Engineering at Instituto Superior de Engenharia de Lisboa (ISEL). She also concluded the course on Laboratory Animal Sciences Category B, conducted by SPCAL and Faculty of Pharmacy, Universidade de Lisboa. Her area of interest is drug delivery systems, namely liposomes and the evaluation of the efficacy and safety of those nanoformulations using in vitro and in vivo models.
Identification

Personal identification

Full name
Mariana Pinto Coelho

Citation names

  • Coelho, Mariana

Author identifiers

Ciência ID
F018-59A8-6A23
ORCID iD
0000-0002-8168-7267
Scopus Author Id
58169549800

Email addresses

  • mariana.coelho@ff.ulisboa.pt (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
Portuguese (Mother tongue)
Education
Degree Classification
2023/12 - 2023/12
Concluded
 Translating Nanomedicines: Principles of Nanomedicines R&D (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Lisboa Faculdade de Farmácia, Portugal
 19
2023/01 - 2023/09
Concluded
 Atualização de Ciências em Animais de laboratório (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 17
2019 - 2022
Concluded
 Engenharia Química e Biológica (Mestrado)
Major in Bioprocessos
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
"Extratos de algas marinhas comestíveis aplicados para a redução do risco de doenças cardiovasculares" (THESIS/DISSERTATION)
 16
2016 - 2019
Concluded
 Engenharia Química e Biológica (Licenciatura)
Major in Processos Biológicos
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
 14
Affiliation

Others

Category
Host institution 		Employer
2023/07 - Current Bolseira de investigação no projeto PTDC/QUI-QIN/0586/2020 "Novel nanoplatforms for targeting melanoma with 8-hydroxyquinoline metal complexes" Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
2022/12 - 2023/06 Bolseira de Investigação no projeto "SkanAbility - Proof of concept for biological activity of cannabinoids and terpenes - cosmeceutical applications" Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10 - 2022/10 Quality Assurance trainee Hikma Pharmaceuticals, Portugal
Projects

Contract

Designation Funders
2023/07 - Current Novel nanoplatforms for targeting melanoma with 8-hydroxyquinoline metal complexes
PTDC/QUI-QIN/0586/2020
Research Fellow
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Ongoing
2022/12 - 2023/06 SkanAbility - Proof of concept for biological activity of cannabinoids and terpenes - cosmeceutical applications
NORTE 01 0247 FEDER 047213
Research Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
Concluded
2022/11 - 2022/12 Rifabutin Liposomes - a novel nanotechnological strategy for effective treatment of systemic methicilin-resistant staphylococus aureus infections.
MMG-2021-092/1-1
Participação no projeto
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Ongoing
Outputs

Publications

Conference poster
  1. Coelho, Mariana; Jacinta O. Pinho; Sandra N. Pinto; M. Manuela Gaspar. "Validating the antibacterial effect of Rifabutin liposomal formulations against a commercial MRSA strain in a systemic murine model". Paper presented in 8th International Symposium on Phospholipid in Pharmaceutical Research, 2024.
  2. Coelho, Mariana; Leonor Côrte-Real ; Nádia Ribeiro; Catarina Pinto Reis; Isabel Correia; M. Manuela Gaspar. "Liposomal nanoformulation of a new copper-based complex with therapeutic potential against melanoma". Paper presented in 8th International Symposium on Phospholipid in Pharmaceutical Research, 2024.
  3. Coelho, Mariana; Catarina Pinto Reis; Ana Paula Francisco; M. Manuela Gaspar. "Alternative therapies based on 5-Fluorouracil against colorectal cancer – in vitro and in vivo models". Paper presented in 15th iMed.ULisboa Postgraduate Students Meeting, 2024.
  4. Coelho, Mariana; Nádia Ribeiro; Farinha, Pedro; Isabel Correia; Catarina Reis; Maria Manuela Gaspar. "Liposomal nanoformulations of novel copper-based complexes with high activity towards melanoma". Paper presented in Spanish-Portuguese Conference on Controlled Drug Delivery, 2024.
  5. Coelho, Mariana; Maria Manuela Gaspar; M. Luísa Serralheiro; Rita Pacheco. "Biological Activities and Therapeutic Potential of Natural Products". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter-Controlled Release Society (SPLC-CRS), 2023.
  6. Coelho, Mariana; A. Patrícia Duarte; Marta Calado; Guilherme Trigo; Susana Santos; António Almeida; Catarina Pinto Reis; Maria Manuela Gaspar. "Cannabinoid-based topical formulations for skin disorders". Paper presented in European Federation for Pharmaceutical sciences, 2023.
  7. Coelho, Mariana; A. Patrícia Duarte; Marta Calado; António Almeida; Guilherme Trigo; Susana Santos; Catarina Pinto Reis; Maria Manuela Gaspar. "Application of cannabinoids in cosmeceutical formulation". Paper presented in 5th International Conference on Natural Products Utilization, 2023.
  8. Coelho, Mariana; Nádia Ribeiro; Farinha, Pedro; Jacinta O. Pinho; Isabel Correia; Catarina Reis; Maria Manuela Gaspar. "Liposomal nanoformulation of copper-based complexes with high activity towards melanoma". Paper presented in 14th iMed.ULisboa Postgraduate Students Meeting, 2023.
  9. Coelho, Mariana; Sofia Pinto; Ana Patrícia Duarte; Hugo Botelho; Catarina Pinto Reis; Maria Luísa Serralheiro; Rita Pacheco. "Edible Seaweeds extracts characterization and prospective health effects". Paper presented in 1st International Congress on Food, Nutrition & Public Health Towards a sustainable future, 2022.
Journal article
  1. Coelho, Mariana P.; Pinho, Jacinta O.; Pinto, Sandra N.; Gaspar, Maria Manuela. "A step forward on the in vitro and in vivo validation of rifabutin-loaded liposomes for the management of highly virulent MRSA infections". Journal of Controlled Release 380 (2025): 348-361. https://doi.org/10.1016/j.jconrel.2025.01.083.
    10.1016/j.jconrel.2025.01.083
  2. Mariana P. Coelho; Pedro F. Farinha; Leonor Côrte-Real; Nádia Ribeiro; Hugo Luiz; Jacinta O. Pinho; Rute Noiva; et al. "Liposomal nanoformulations of novel copper-based complexes exhibiting antimelanoma activity – In vitro and in vivo validation". International Journal of Pharmaceutics (2025): https://doi.org/10.1016/j.ijpharm.2025.125643.
    10.1016/j.ijpharm.2025.125643
  3. Jacinta O. Pinho; Mariana Coelho; Catarina Pimpão; Jahnobi Konwar; Ana Godinho-Santos; Rute M. Noiva; Sophie R. Thomas; et al. "Liposomal Formulation of an Organogold Complex Enhancing Its Activity as Antimelanoma Agent—In Vitro and In Vivo Studies". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16121566.
    10.3390/pharmaceutics16121566
  4. Guilherme Trigo; Mariana Coelho; Carolina Borges Ferreira; Matteo Melosini; Inês Sousa Lehmann; Catarina P. Reis; Maria Manuela Gaspar; Susana Santos. "Exploring the Biological Activity of Phytocannabinoid Formulations for Skin Health Care: A Special Focus on Molecular Pathways". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms252313142.
    10.3390/ijms252313142
  5. Jacinta O. Pinho; Magda Ferreira; Mariana Coelho; Sandra N. Pinto; Sandra I. Aguiar; Maria Manuela Gaspar. "Liposomal Rifabutin—A Promising Antibiotic Repurposing Strategy against Methicillin-Resistant Staphylococcus aureus Infections". Pharmaceuticals (2024): https://doi.org/10.3390/ph17040470.
    10.3390/ph17040470
  6. Azevedo, Afonso; Coelho, Mariana P.; Pinho, Jacinta O.; Soares, Paula I.P.; Reis, Catarina P.; Borges, João P.; Gaspar, M. Manuela. "An alternative hybrid lipid nanosystem combining cytotoxic and magnetic properties as a tool to potentiate antitumor effect of 5-fluorouracil". Life Sciences (2024): 122558. http://dx.doi.org/10.1016/j.lfs.2024.122558.
    10.1016/j.lfs.2024.122558
  7. Coelho, Mariana Pinto; Duarte, Patrícia; Calado, Marta; Almeida, António J.; Reis, Catarina Pinto; Gaspar, M. Manuela. "The current role of cannabis and cannabinoids in health: A comprehensive review of their therapeutic potential". Life Sciences (2023): 121838. http://dx.doi.org/10.1016/j.lfs.2023.121838.
    Published • 10.1016/j.lfs.2023.121838
  8. Coelho, Mariana; Pacheco, Rita. "Anti-Hypercholesterolemia Effects of Edible Seaweed Extracts and Metabolomic Changes in Hep-G2 and Caco-2 Cell Lines". Life 13 6 (2023): 1325. http://dx.doi.org/10.3390/life13061325.
    Published • 10.3390/life13061325
  9. Coelho, M.; Duarte, A.P.; Pinto, S.; Botelho, H.M.; Reis, C.P.; Serralheiro, M.L.; Pacheco, R. Edible Seaweeds Extract. "Edible Seaweeds Extracts: Characterization and Functional Properties for Health Conditions". Antioxidants 12 684 (2023): 1-16. https://www.mdpi.com/2076-3921/12/3/684.
    Open access • Published • https://doi.org/10.3390/antiox12030684
Preprint
  1. Rita Pacheco; Mariana Coelho. "Anti-Hypercholesterolemia Effects of Edible Seaweeds Extracts and Metabolomic Changes in Hep-G2 and Caco-2 Cell Lines". 2023. https://doi.org/10.20944/preprints202305.0631.v1.
    10.20944/preprints202305.0631.v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07 Advancing the treatment of infectious diseases - the key role of liposomes as delivery systems Workshop - Recent advances in the use of phospholipids excipients,   Integrating Delivery Science across disciplines
Controlled Release Society (CRS) (Bolonha, Italy)
2024/02 Advancing the treatment of Staphylococcus aureus with rifabutin-loaded liposomes - in vitro and in vivo studies Spanish Portuguese Local Chapter - Controlled Release Society (SPLC-CRS)
Faculty of Pharmacy, Universidade de Lisboa (Lisboa, Portugal)
2023/11 Oxidovanadium(IV) complexes containing 8-hydroxyquinoline Schiff bases – synthesis, characterization and biological screening 13th International Vanadium Symposium
Calouste Gulbenkian Foundation, Lisboa (Portugal)
2023/03/18 Exploring rifabutin liposomes as a novel therapeutic approach against Staphylococcus aureus infections Update on antimicrobial research: Joint struggle against the silent pandemic
Universitat Heidelberg