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João has a Master's Degree in Biopharmaceutical Sciences from the Faculty of Pharmacy, University of Lisbon, and a Degree in Pharmacy obtained from Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL - Lisbon Polytechnic Institute). His research career has been mainly related to the area of inflammation, including inflammatory bowel disease, colitis-associated cancer, and periodontitis, through the development of reliable animal models of disease and the evaluation of potential pharmacological approaches. Currently, João is a PhD student (iMed/Faculty of Pharmacy of the University of Lisbon (FFUL)), intending to develop iPSCS-derived 3D in vitro liver cultures to evaluate the biological machinery involved in idiosyncratic drug-induced liver injury, allied with the identification of predictive biomarkers. Furthermore, he is also interested in discovering biomarkers that define key stages in the Healthy-to-NASH/MASLD transition, using liver microphysiological systems. João is also an invited assistant professor at ESTeSL (Degree in Pharmacy), lecturing on the curricular units of "Farmacologia e Toxicologia", "Farmacoterapia II", and "Farmacoterapia III". At the moment, he has collaborated on 8 funded projects and authored/co-authored 11 articles (6 as first author), published in international research journals, 11 oral communications, and 2 conference posters.
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Identification

Personal identification

Full name
João Paulo Henriques Estarreja

Citation names

  • Estarreja, João

Author identifiers

Ciência ID
EB19-EDA2-704B
ORCID iD
0000-0002-8283-3174

Email addresses

  • joaoestarreja@edu.ulisboa.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2024/10/25 - 2028
Ongoing
 Pharmaceutical Sciences (Doutoramento)
Major in Toxicology
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09/27 - 2023/12/04
Concluded
 Biopharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
""Development of an experimental model of periodontitis in rodents: preliminary study towards to the evaluation of its influence in female fertility" " (THESIS/DISSERTATION)
 19
2021/01 - 2021/09
Concluded
 Certification on Animal Experimentation (Category B) - Postgraduate Science Update Course in Laboratory Animals (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
T: 90% / P: 19 (0-20)
2017 - 2021
Concluded
 Pharmacy (Licenciatura)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
""Effect of Erythropoietin in a Chronic TNBS-induced Colitis Model in Rodents"" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2025/02 - Current Researcher (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2022/02 - 2025/02 Researcher (Research) H&TRC - Health and Technology Research Center, Portugal
H&TRC - Health and Technology Research Center, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024 - Current Invited Assistant (Polytechnic Teacher) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Other Careers

Category
Host institution 		Employer
2021/11 - 2023/11 Técnico de 1ª Classe (Técnico de Diagnóstico e Terapêutica- Técnico de Farmácia) Farmácia Barral, Portugal
2021/04 - 2021/05 Estagiário (3º e 4º Ano) (Técnico Superior de Saúde) Farmácia Varela, Portugal
2021/01 - 2021/03 Estagiário (3º e 4º Ano) (Técnico Superior de Saúde) Hospital de Vila Franca de Xira, Portugal
Projects

Grant

Designation Funders
2023 - 2024 TransIbu - Efficacy and safety of transdermal ibuprofen ionic liquids in an animal model of acute colitis.
IPL/IDI&CA2023/TransIbu_ESTeSL
Researcher
H&TRC - Health and Technology Research Center, Portugal
 Instituto Politécnico de Lisboa
Ongoing
2023 - 2024 COLEpiGen - Hemin effects on the epigenetic regulation of SETD8 methyltransferase in the Inflammatory Bowel Disease: An Experimental Model of Chronic Colitis.
IPL/IDI&CA2023/COLEpiGen_ESTeSL
Researcher
H&TRC - Health and Technology Research Center, Portugal
 Instituto Politécnico de Lisboa
Ongoing
2023 - 2024 PRODUCTIVE - PorphyRomonas gingivalis assOciated inflammation on female reproduCTIVE tissues
2022.02119.PTDC
Researcher
Instituto Universitário Egas Moniz Centro de Investigação Interdisciplinar Egas Moniz, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2023 RetCol - Innovative evaluation of potencial RETinal lesions in a chronic COLitis model in rodents: new contribute for the diagnosis and follow-up of colitis patients.
IPL/2022/RetCOL_ESTeSL
Researcher
H&TRC - Health and Technology Research Center, Portugal
 Instituto Politécnico de Lisboa
Concluded
2022 - 2023 CoIbu-Ils - Efficacy and safety of transdermal Ibuprofen Ionic Liquids in an animal model of chronic TNBS-induced colitis.
IPL/2022/ColIbu-ILs_ESTeSL
Researcher
H&TRC - Health and Technology Research Center, Portugal
 Instituto Politécnico de Lisboa
Concluded
2021 - 2023 PETIT - Periodontal health and fErtiliTy In raTs
N.D.
Researcher
Instituto Universitário Egas Moniz Centro de Investigação Interdisciplinar Egas Moniz, Portugal
 Instituto Universitário Egas Moniz Centro de Investigação Interdisciplinar Egas Moniz
Concluded
2021 - 2022 PharmCAC - Pharmacological Modulation of Colitis-associated Colon Cancer: validation of an animal model in rodents.
IPL/2021/PharmCAC_ESTeSL
Researcher
H&TRC - Health and Technology Research Center, Portugal
 Instituto Politécnico de Lisboa
Concluded
2020 - 2021 cEPO - Efficacy and safety of the carbamylated erythropoietin in an animal model of chronic TNBS-induced colitis
IPL/2020/cEPO_ESTeSL
Researcher
H&TRC - Health and Technology Research Center, Portugal
 Instituto Politécnico de Lisboa
Concluded
Outputs

Publications

Conference poster
  1. Modesto, Rita; Estarreja, João; Machado, Vanessa; Rocha, João; Pinto, Rui; Mateus, Vanessa. "Periodontitis influence towards female fertility: development of an animal model". Paper presented in Encontro Ciência 2024, 2024.
    N.A.
  2. Machado, Vanessa; Estarreja, João; Vilares, Maria; Mateus, Vanessa; Mascarenhas, Paulo; Rocha, João; Pinto, Rui; et al. "Periodontite na inflamação sistémica e do sistema reprodutor feminino: estudo em ratos". Paper presented in 201ª Reunião da Sociedade Portuguesa de Ginecologia, 2023.
    N.A.
Journal article
  1. Estarreja, João; Mendes, Priscila; SiIva, Carina; Camacho, Pedro; Mateus, Vanessa. "Off-Label Use of Bevacizumab in Patients Diagnosed with Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis". Pharmaceuticals 17 8 (2024): 1000.
    Published • 10.3390/ph17081000
  2. Estarreja, João; Caldeira, Gonçalo; Silva, Inês; Mendes, Priscila; Mateus, Vanessa. "The Pharmacological Effect of Hemin in Inflammatory-related Diseases: A Systematic Review". Biomedicines 12 4 (2024): 898.
    Published • 10.3390/biomedicines12040898
  3. Estarreja, João; Pimenta, Ana Clara; Botelho, João; Vilares, Arminda Maria; Mendes, José João; Rocha, João; Pinto, Rui; Mateus, Vanessa; Machado, Vanessa. "Blood count, endocrine, immunologic, renal, and hepatic markers in a case-control animal study of induced periodontitis in female rodents". Frontiers in Physiology 15 (2024): http://dx.doi.org/10.3389/fphys.2024.1327399.
    10.3389/fphys.2024.1327399
  4. Estarreja, João; Caldeira, Gonçalo; Silva, Inês; Mendes, Priscila; Mateus, Vanessa. "The Pharmacological Effect of Hemin in Inflammatory-Related Diseases: Protocol for a Systematic Review". JMIR Research Protocols 12 (2023): e48368. http://dx.doi.org/10.2196/48368.
    10.2196/48368
  5. Silva, Inês; Gomes, Mário; Alípio, Carolina; Vitoriano, Jéssica; Estarreja, João; Mendes, Priscila; Pinto, Rui; Mateus, Vanessa. "Effect of Carbamylated Erythropoietin in a Chronic Model of TNBS-Induced Colitis". Biomedicines 11 9 (2023): 2497. http://dx.doi.org/10.3390/biomedicines11092497.
    10.3390/biomedicines11092497
  6. Estarreja, João; Mendes, Priscila; Silva, Carina; Camacho, Pedro; Mateus, Vanessa. "The Efficacy, Safety, and Efficiency of the Off-Label Use of Bevacizumab in Patients Diagnosed With Age-Related Macular Degeneration: Protocol for a Systematic Review and Meta-Analysis". JMIR Research Protocols 12 (2023): e38658. http://dx.doi.org/10.2196/38658.
    10.2196/38658
  7. Silva, Inês; Estarreja, João; Pinto, Rui; Mateus, Vanessa. "Efficacy and safety of erythropoietin in a chronic model of Inflammatory Bowel Disease". Biomedicine & Pharmacotherapy 156 (2022): 113944. http://dx.doi.org/10.1016/j.biopha.2022.113944.
    10.1016/j.biopha.2022.113944
  8. Estarreja, João; Silva, Inês; Mateus, Vanessa. "Inflammatory Bowel Disease: Current Treatment and Future Perspectives". Journal of Chronic Diseases Research 1 1 (2022): 1001-1012.
    Published
  9. Mateus, Vanessa; Estarreja, João; Silva, Inês; Gonçalves, Fernando; Teixeira-Lemos, Edite; Pinto, Rui. "Effect of Aqueous Extract of Phenolic Compounds Obtained from Red Wine in Experimental Model of Colitis in Mice". Current Issues in Molecular Biology 44 6 (2022): 2745-2758. http://dx.doi.org/10.3390/cimb44060188.
    10.3390/cimb44060188
  10. Modesto, Rita; Estarreja, João; Silva, Inês; Rocha, João; Pinto, Rui; Mateus, Vanessa. "Chemically Induced Colitis-Associated Cancer Models in Rodents for Pharmacological Modulation: A Systematic Review". Journal of Clinical Medicine 11 10 (2022): 2739. http://dx.doi.org/10.3390/jcm11102739.
    10.3390/jcm11102739
  11. Mateus, Vanessa; Estarreja, João; Silva, Inês; Barracosa, Paulo; Teixeira-Lemos, Edite; Pinto, Rui. "Effect of Cynara cardunculus L. var. altilis (DC) in Inflammatory Bowel Disease". Applied Sciences 11 4 (2021): 1629. http://dx.doi.org/10.3390/app11041629.
    10.3390/app11041629
Preprint
  1. Estarreja, João; Mendes, Priscila; Silva, Carina; Camacho, Pedro; Mateus, Vanessa. "The Efficacy, Safety, and Efficiency of the Off-Label Use of Bevacizumab in Patients Diagnosed With Age-Related Macular Degeneration: Protocol for a Systematic Review and Meta-Analysis (Preprint)". 2022. http://dx.doi.org/10.2196/preprints.38658.
    10.2196/preprints.38658
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/02/07 Animal model of experimental periodontitis for testing new pharmacological approaches LV Reunião da Sociedade Portuguesa de Farmacologia/XLIII Reunião de Farmacologia Clínica/XXIV Reunião de Toxicologia
Portuguese Society of Pharmacology (Porto, Portugal)
2024/11/07 Transdermal Ibuprofen Ionic Liquids in an Animal Model of Acute Colitis International Conference on Applied Science & Engineering
Applied Science (Vienna, Austria)
2024/10/18 Can Ibuprofen Ionic Liquids Mitigate the Risk of Cancer Associated with TNBS-Induced Colitis? 12º Congresso Nacional da APLF
Associação Portuguesa de Licenciados em Farmácia (Lisbon, Portugal)
2024/09/24 Epigenetic Regulation of SETD8 Methyltransferase in TNBS-induced Colitis Treated with Carbamylated Erythropoietin 2nd Euro-Global Summit on Advances in Clinical and Cellular Immunology
Peers Alley Media (Barcelona, Spain)
2024/09/11 Carbamylated Erythropoietin Effects on the Epigenetic Regulation of SETD8 Methyltransferase: an Experimental Model of Chronic Colitis VI H&TRC BootCamp 2024
Health and Technology Research Center (Santarém, Portugal)
2024/06/27 Characterization and validation of human in vitro models with hepatic functional and phenotypic markers Halt-RONIN - 2nd Annual Meeting
Faculty of Pharmacy, University of Lisbon (Lisbon, Portugal)
2024/06/21 Neuropharmacological modulation in ischemic stroke: development of a rodent model of transient middle cerebral artery occlusion Science Break
Health and Technology Research Center (Lisbon, Portugal)
2023/12/18 Periodontal health and fertility: a non-clinical study in rats III Webinar de Investigação Aplicada em Farmácia
Escola Superior de Tecnologia da Saúde de Lisboa (Lisbon, Portugal)
2023/02 Development of an experimental model of periodontitis in rodents: preliminary study towards to the evaluation of its influence in female fertility. III Workshop of the Masters in Biopharmaceutical Sciences
Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2022/12/20 Periodontal health and fertility: Non-clinical study in rat II Webinar de Investigação Aplicada em Farmácia
Escola Superior de Tecnologia da Saúde de Lisboa (Lisbon, Portugal)
2021/12 Effect of Erythropoietin in a Chronic TNBS-induced Colitis Model in Rodents III Seminário de Investigação Aplicada em Farmácia
Escola Superior de Tecnologia da Saúde de Lisboa (Lisbon, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/09/07 - 2024/09/08 Comprehensive Hands-on Sessions; Advanced Differentiation Protocols; Expert-led Seminars. Grant from COST Action CA20140 "CorEuStem"
Workshop
 Hands-on Training on 2D and 3D Differentiation of hPSC
Erasmus MC, Netherlands

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024 - Current Farmacoterapia II Farmácia (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2023 - Current Farmacoterapia III Farmácia (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2022 - Current Farmacologia e Toxicologia Farmácia (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
Distinctions

Award

2021 Prémio Caixa Geral de Depósitos
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Other distinction

2023 Highly Viewed Papers of CIMB - Awarded article: "Effect of Aqueous Extract of Phenolic Compounds Obtained from Red Wine in Experimental Model of Colitis in Mice".
Current Issues of Molecular Biology, Switzerland