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Carla Sofia Palma Grosso completed her PhD in Chemistry on July 11, 2023, at the University of Coimbra, Faculty of Science and Technology. Prior to that, she earned an Master in Food Technology on July 27, 2011, from the University of Algarve, Higher Engineering Institute, and she obtained a Bachelor’s Degree in Chemistry - Scientific Branch on December 15, 2006, at the University of Algarve, Gambelas Campus. Currently, she is attending a Master’s program in Teaching Physics and Chemistry for the 3rd Cycle of Basic Education and Secondary Education at the University of Coimbra, Department of Physics, starting from September 1, 2024. Throughout her academic and professional career, she has published 11 articles in scientific journals and organized 1 event. Carla has received 1 award and/or honor and has participated as an Integration into Research Grant Fellow in 2 projects, as well as a PhD Student Fellow in 1 project. Her work focuses on Exact Sciences, with an emphasis on Chemical Sciences and Organic Chemistry. In her professional activities, she has collaborated with 57 co-authors on scientific papers. The most frequent terms highlighted in her Ciência Vitae include Nitrosoalkenes, Azoalkenes, Bis(indolyl)methanes, and Natural Deep Eutectic Solvents.
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Identification

Personal identification

Full name
Carla Sofia Palma Grosso

Citation names

  • Grosso, Carla

Author identifiers

Ciência ID
E01F-48D7-D37F
ORCID iD
0000-0003-1999-3471

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2024/09/01 - 2026/07/31
Ongoing
 Mestrado em Ensino de Física e de Química no 3.º ciclo do Ensino Básico e no Ensino Secundário (Mestrado)
Universidade de Coimbra Departamento de Física, Portugal
2023/07/11
Concluded
 Química (Doutoramento)
Major in Especialidade: Síntese Orgânica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Synthesis of Novel Indoles and Bis(indolyl)methanes: Approaches to Structures with Biological Activity " (THESIS/DISSERTATION)
 distinction and praise
2008/09/01 - 2011/07/27
Concluded
 Tecnologia de Alimentos (Mestrado integrado)
Universidade do Algarve Instituto Superior de Engenharia, Portugal
"Produção de butirato de etilo catalisada por lipases imobilizadas" (THESIS/DISSERTATION)
 18
2003/09/01 - 2006/12/15
Concluded
 Licenciatura em Química- ramo científico (Licenciatura)
Universidade do Algarve - Campus de Gambelas, Portugal
"Síntese, caracterização, e estudos catalíticos em reacções de oxidação do complexo de MoO2Cl2" (THESIS/DISSERTATION)
 13
Affiliation

Others

Category
Host institution 		Employer
2022/05/01 - 2023/03/31 FORMADORA DE CURSOS PROFISSIONAIS Novotecna Associação para o Desenvolvimento Tecnológico Centro de Empresas Tecnológicas de Coimbra, Portugal
2004/07/01 - 2011/08/31 Monitora, Professora AEC Centro Ciência Viva do Algarve, Portugal
Projects

Grant

Designation Funders
2017/09/01 - 2021/08/31 Synthesis of Novel Indoles and Bis(indolyl)methanes: Approaches to Structures with Biological Activity
SFRH/BD/130198/2017
PhD Student Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01 - 2019/12 Centro de Química - Coimbra
154634UID
UID/QUI/00313/2019
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Química de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/10/01 - 2013/12/31 Síntese de Bis- eTris(heteroaril)metanos via Ciclo-adições de Hetero Diels-Alder
4023(CIQA)
Integration into Research Grant Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2011/11/01 - 2013/03/31 PHARMATLANTIC- Knowledge Transfer Network for Prevention of Mental Diseases and Cancer in Atlantic Area
2009-1/117
Integration into Research Grant Fellow
Universidade do Algarve - Campus de Gambelas, Portugal
Concluded
Outputs

Publications

Conference paper
  1. Grosso, Carla; Terver J. Sase; Nuno G. Alves; Lemos, Americo; Ana L. Cardoso; Teresa M. V. D. Pinho e Melo. "Exploring the Reactivity of Tetrazolyl-2H-Azirines toward Arynes: Selective Synthesis of Indole Derivatives". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, Lisbon, 2022.
    Published
Conference poster
  1. Alves, Cláudia; Grosso, Carla; Ana L. Cardoso; Teresa M. V. D. Pinho e Melo. "Selective Synthesis of 3-(1H-Tetrazol-5-yl)-Indoles from 2H-Azirines and Arynes: Optimization of the new synthetic route". Paper presented in Synthesis & Catalysis Workshop 2023, 2023.
  2. Terver John Sase; Nuno Guerreiro Alves; Ana L. Cardoso; Américo Lemos; Teresa M. V. D. Pinho e Melo. "Exploring the reactivity of tetrazolyl-2H-azirines towards arynes: selective synthesis of indole derivatives". Paper presented in 14th national organic chemistry meeting & 7th national medicinal chemistry meeting, 2022.
  3. Ana L. Cardoso; Américo Lemos; Teresa M. V. D. Pinho e Melo. "Synthesis of Novel Indoles and Bis(indolyl)methanes: Approaches to Structures with Biological Activity". Paper presented in Coimbra Chemistry Centre Day, 2021.
  4. Grosso, Carla; Alves, Nuno. "Selective Synthesis of 3-Tetrazolyl-indoles from 2-(Tetrazol-5-yl)-2H-azirines and Arynes". Paper presented in International symposium on synthesis and catalysis ISYSYCAT 2021, 2021.
  5. Grosso, Carla; Alves, Claudia; Anthony J. Burke; Lemos, Americo; Teresa M.D.V. Pinho e Melo. "Asymmetric Neber Reaction in the Synthesis of Tetrazolyl-Azirine Assemblies". Paper presented in ISYSYCAT 2019, 2019.
  6. Grosso, Carla; Amadeu Brigas; Americo Lemos; Teresa M.D.V. Pinho e Melo. "Natural Deep Eutectic Solvents in the Hetero-Diels-Alder Approach to Bis(indolyl)methanes". Paper presented in talian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry MedChemSicily2018, 2018.
  7. Grosso, Carla. "Natural Deep Eutectic Solvents in the Synthesis of Bis(indoly)methanes". Paper presented in 12th National Organic Chemistry Meeting and5th National Medicinal Chemistry Meeting, 2018.
  8. Grosso, Carla; Ana L. Cardoso; Americo Lemos; Teresa M.D.V. Pinho e Melo. "New Bis(indolyl)methane Hydrazones with Potencial Biological Activity". Paper presented in 7th Spanish-Portuguese-Japonese Organic Chemistry Symposium June, 2015.
  9. Américo Lemos; João Varela; Luísa Barreira; Luísa Custódio; Maria João Rodrigues; Teresa M. V. D. Pinho e Melo. "Novel Synthesis of Bis(indolyl)methanes with Anticancer Properties". Paper presented in XXII International Symposium on Medicinal Chemistry EFMC/ISMC, 2014.
  10. Grosso, Carla. "Modelling and Optimization of Ethyl Butyrate Production by Response Surface Methodology". Paper presented in ISEKI Milão 2011, 2011.
  11. Grosso, Carla. "Screening of Immobilized Lipases for the Synthesis of Ethyl Butyrate". Paper presented in ESBES Bolonha 2010, 2010.
  12. Grosso, Carla. "COMPARISON OF LIQUID-PHASE OLEFIN EPOXIDATION CATALYSED BY DICHLOROBIS-(DIMETHYLFORMAMIDE)DIOXOMOLYBDENUM(VI) IN HOMOGENEOUS PHASE AND GRAFTED ONTO MCM-41". Paper presented in Jornadas Ciceco, 2009.
Journal article
  1. Grosso, Carla; Alves, Cláudia; Sase, Terver J.; Alves, Nuno G.; Cardoso, Ana L.; Lemos, Américo; Pinho e Melo, Teresa M. V. D.. "Selective Synthesis of 3-(1H-Tetrazol-5-yl)-indoles from 2H-Azirines and Arynes". ACS Omega 9 27 (2024): 29282-29289. http://dx.doi.org/10.1021/acsomega.4c00305.
    10.1021/acsomega.4c00305
  2. Grosso, Carla; Alves, C.; Terver, J. S.; Alves, N.; Ana L. Cardoso; Lemos, Americo; Pinho e Melo, T.M.V.D.. "Selective Synthesis of 3-(1H-Tetrazol-5-yl)-Indoles from 2H-Azirines and Arynes". ACS Omega (2024):
    Accepted
  3. Ana L. Cardoso; Susana M. M. Lopes; Carla Grosso; Marta Pineiro; Américo Lemos; Teresa M. V. D. Pinho e Melo. "One-Pot Synthetic Approach to Dipyrromethanes and Bis(indolyl)methanes via Nitrosoalkene Chemistry". Journal of Chemical Education (2021): https://doi.org/10.1021/acs.jchemed.1c00184.
    10.1021/acs.jchemed.1c00184
  4. Cláudia Alves; Carla Grosso; Pedro Barrulas; José A. Paixão; Ana L. Cardoso; Anthony J. Burke; Américo Lemos; Teresa M. V. D. Pinho e Melo. "Asymmetric Neber Reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirines". Synlett (2019): https://doi.org/10.1055/s-0039-1691533.
    10.1055/s-0039-1691533
  5. Grosso, C.; Brigas, A.; de los Santos, J.M.; Palacios, F.; Lemos, A.; Pinho e Melo, T.M.V.D.. "Natural deep eutectic solvents in the hetero-Diels–Alder approach to bis(indolyl)methanes". Monatshefte fur Chemie 150 7 (2019): 1275-1288. https://link.springer.com/article/10.1007/s00706-019-02421-7.
    10.1007/s00706-019-02421-7
  6. Grosso, C.; Liber, M.; Brigas, A.F.; Pinho E Melo, T.M.V.D.; Lemos, A.. "Regioselectivity in Hetero Diels-Alder Reactions". Journal of Chemical Education 96 1 (2019): 148-152. https://pubs.acs.org/doi/10.1021/acs.jchemed.7b00933.
    10.1021/acs.jchemed.7b00933
  7. Carla Grosso; Ana L. Cardoso; Maria João Rodrigues; Cátia Marques; Luísa Barreira; Américo Lemos; Teresa M.D.V. Pinho e Melo. "Hetero-Diels-Alder approach to Bis(indolyl)methanes". Bioorganic & Medicinal Chemistry (2017):
    10.1016/j.bmc.2016.12.028
  8. Carla Grosso; Americo Lemos; Teresa M. V. D. Pinho e Melo. "ChemInform Abstract: Conjugate Addition of Pyrazoles to Halogenated Nitroso- and Azoalkenes: A New Entry to Novel Bis(pyrazol-1-yl)methanes.". ChemInform 46 20 (2015): no-no. http://dx.doi.org/10.1002/chin.201520145.
    10.1002/chin.201520145
  9. Carla Grosso; Ana Lúcia Cardoso; Américo Lemos; João Varela; Maria João Rodrigues; Luísa Custódio; Luísa Barreira; Teresa M.V.D. Pinho e Melo. "Novel approach to bis(indolyl)methanes: De novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties". European Journal of Medicinal Chemistry 93 (2015): 9-15. http://dx.doi.org/10.1016/j.ejmech.2015.01.050.
    10.1016/j.ejmech.2015.01.050
  10. Grosso, Carla. "Conjugate Addition of Pyrazoles to Halogenated Nitroso- and Azoalkenes: A New Entry to Novel Bis(pyrazol-1-yl)methanes". Synlett (2014):
    10.1055/s-0034-1379306
  11. Grosso, C.; Ferreira-Dias, S.; Pires-Cabral, P.. "Modelling and optimization of ethyl butyrate production catalysed by Rhizopus oryzae lipase". Journal of Food Engineering 115 4 (2013): 475-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877616830&partnerID=MN8TOARS.
    10.1016/j.jfoodeng.2012.08.001
  12. Monteiro, Bernardo; Balula, Salete S.; Gago, Sandra; Grosso, Carla; Figueiredo, Sónia; Lopes, André D.; Valente, Anabela A.; et al. "Comparison of liquid-phase olefin epoxidation catalysed by dichlorobis-(dimethylformamide)dioxomolybdenum(VI) in homogeneous phase and grafted onto MCM-41". Journal of Molecular Catalysis A: Chemical 297 2 (2009): 110-117. http://dx.doi.org/10.1016/j.molcata.2008.09.012.
    10.1016/j.molcata.2008.09.012
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2015/12/01 Synthesis of new bis(indolyl)methanes with anti-cancer properties 11º Encontro Nacional de Química Orgânica e 4º Encontro Nacional de Química Terapêutica
Portuguese Society of Chemistry (Porto, Portugal)
2014/09/16 Novel Synthesis of Bis(indolyl)methanes with Anticancer Properties Encontro Centro de Química de Coimbra
Centro de Química de Coimbra (Coimbra , Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/09/01 - 2018/01/19 Member of the organising committee of the 12th National Organic Chemistry Meeting 5th National Medicinal Chemistry Meeting 17th - 19th January 2018, Coimbra – Portugal (2018/01/17 - 2018/01/19)
Meeting (Member of the Organising Committee)
Distinctions

Award

2022 Best Poster in Organic Chemistry