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Invited Assistant Professor at the Faculty of Pharmacy of the University of Coimbra since 2021, with previous teaching experience at the Faculty of Health Sciences of the University of Beira Interior. Doctoral and Master's degree in Pharmaceutical Sciences from University of Beira Interior. Academic scientific research focused on the pharmaceutical sciences field, more specifically on nanotechnology, pharmaceutical technology, and analytical chemistry. Experience in teaching Pharmaceutical Sciences, Pharmaceutical Technology, Bioanalytical Sciences, Biomedical Pharmacy, and Biomedical Sciences graduate and undergraduate students. Lecture, theoretical-practical and laboratory-type classes. Past and current subjects include (alphabetical order): Applied Pharmaceutical Development; Dermopharmacy and Cosmetics; Drugs and Medicines; Galenic Pharmacy; Galenic Pharmacy and Pharmaceutical Technology; Medical Devices; Metrology and Analytical Validation; Nanotechnology; Pharmaceutical Development of Medicines; Pharmaceutical Quality Control; Pharmaceutical Technology I; Pharmaceutical Technology II; Pharmaceutical Technology III; Quality Management; Veterinary Medicines.
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Identification

Personal identification

Full name
Patrícia Sofia Cabral Pires

Citation names

  • Pires, Patrícia C.
  • Pires, P. C.
  • Patrícia C. Pires
  • P. C. Pires

Author identifiers

Ciência ID
DF1D-73CF-6BA4
ORCID iD
0000-0003-0036-4894

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Exact Sciences - Chemical Sciences - Analytical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2016/10 - 2021/03
Concluded
 Doctoral Degree in Pharmaceutical Sciences (Doutoramento)
Universidade da Beira Interior, Portugal
"The promise of prodrugs and nanosystems in nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin" (THESIS/DISSERTATION)
 Approved
2011/09 - 2016/06
Concluded
 Integrated Master's Degree in Pharmaceutical Sciences (Mestrado integrado)
Universidade da Beira Interior, Portugal
"Síntese de derivados da estrona funcionalizados nos anéis C e D como potenciais agentes anticancerígenos" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2021/04 - Current Visiting Researcher (Research) Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
2014/06 - 2021/03 Researcher (Research) Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/10/01 - Current Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09 - 2021/03 Tutor (University Teacher) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2018/09 - 2020/02 ICON: Interdisciplinary Challenges On Neurodegeneration
CENTRO-01-0145-FEDER-000013
PhD Student Fellow
Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
 Universidade da Beira Interior
Concluded
Outputs

Publications

Book chapter
  1. Pires, Patrícia C.; Melo, Dora; Santos, Adriana O.. "Intranasal delivery of antiseizure drugs". In Drug Delivery Devices and Therapeutic Systems, edited by Eric Chappel, 623-646. Elsevier, 2021.
    Published • 10.1016/b978-0-12-819838-4.00022-5
Conference paper
  1. Patrícia C. Pires; Mafalda Rodrigues Luis Correia; Francisco Veiga; Ana Cláudia Paiva-Santos. "Anti-Inflammatory Drug Repurposing for Intranasal Delivery: Ketoprofen Nanoemulgel Development for the Treatment of Glioma". 2023.
    10.3390/asec2023-15345
  2. Margarida Alberto; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "Intranasal Nanoparticles for the Treatment of Depression and Anxiety Disorders". 2022.
    10.3390/asec2022-13853
  3. Maria Ferreira; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "The Importance of Nanosystems in Antipsychotic Drugs Brain Targeting". 2022.
    10.3390/asec2022-13765
  4. Jéssica Lopes Antunes; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "Brain Targeting of Antidepressant and Anxiolytic Drugs". 2022.
    10.3390/asec2022-13766
  5. Joana Amado; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Miconazole Nanoemulsions to Treat Melanoma: A Study of Formulation Development, Droplet Size and Solubility". 2022.
    10.3390/ecmc2022-13416
  6. P. Pires; A.C. Santos; F. Veiga. "Nanometric emulsions for the treatment of depressive and anxiety disorders". 2022.
    10.1016/j.nsa.2022.100337
Conference poster
  1. Fernando Silva; Francisco Veiga; Patrícia C. Pires; Amélia C. F. Vieira; Vera Moura; Ana Cláudia Paiva-Santos. "Development of a nanoemulsion for intravenous administration of paracetamol in combination with ketoprofen". Paper presented in XIX International CICS-UBI Symposium, 2024.
  2. Maria Beatriz Pinto; Mafalda Correia; Moço, Gabriela; Amélia Vieira; Francisco Veiga; Patrícia C. Pires; Ana Cláudia Paiva-Santos. "Niosomes development and characterization for topical delivery of hydrophobic compounds". Paper presented in X Congresso Iberoamericano das Ciências Farmacêuticas, Coimbra, Portugal, 2023.
  3. Patrícia C. Pires; Mafalda Correia; Francisco Veiga; Ana Cláudia Paiva-Santos. "Repurposing old drugs for new targets: Ketoprofen intranasal nanoemulgel development for the treatment of glioma". Paper presented in X Congresso Iberoamericano das Ciências Farmacêuticas, Coimbra, Portugal, 2023.
  4. Joana Amado; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Miconazole nanoemulsions for the topical treatment of melanoma: Formulation development and characterization". Paper presented in X Congresso Iberoamericano das Ciências Farmacêuticas, Coimbra, Portugal, 2023.
  5. Francisco Veiga; Patrícia C. Pires; Matilde Rodrigues; Ana Cláudia Paiva-Santos. "Drug repurposing and nanosystems for the treatment of glioma: ketoprofen nanoemulgel development and characterization". Paper presented in CRS 2023 Annual Meeting, Las Vegas, Nevada, USA, 2023.
  6. Matilde Rodrigues; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Drug repurposing and nanosystems for the treatment of melanoma: Novel ketoprofen nanoemulsion development and characterization". Paper presented in XII In4Med, Coimbra, Portugal, 2023.
  7. Joana Amado; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Formulation development and characterization of miconazole nanoemulsions for melanoma treatment". Paper presented in XII In4Med, Coimbra, Portugal, 2023.
  8. Maria Beatriz Pinto; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Encapsulation of hydrophilic compounds into niosomes for skin application". Paper presented in XII In4Med, Coimbra, Portugal, 2023.
  9. Griesi, M; Patrícia C. Pires; Francisco Veiga; Tosi, G; Ana Cláudia Paiva-Santos. "Development of a novel nanoemulgel for topical delivery of hydrophobic compounds". Paper presented in XII In4Med, Coimbra, Portugal, 2023.
  10. Joana Amado; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Miconazole nanoemulsions to treat melanoma: formulation development and droplet size and solubility studies". Paper presented in 8th International Electronic Conference on Medicinal Chemistry, 2022.
  11. Ana Cláudia Paiva-Santos; Matilde Rodrigues; Patrícia C. Pires; Francisco Veiga. "Ketoprofen Nanoemulsions for Melanoma Treatment: Formulation, Development and Characterization". Paper presented in 13th Annual Meeting on Skin Ageing & Challenges, 2022.
  12. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Improving drug solubility and brain bioavailability of antipsychotics through nanometric emulsions". Paper presented in 35th European College of Neuropsychopharmacology (ECNP) Congress, 2022.
  13. Matilde Rodrigues; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Ketoprofen nanoemulsions for cancer treatment". Paper presented in 17th YES - Young European Scientist Meeting, 2022.
  14. Patrícia C. Pires; Matilde Rodrigues; Ana Cláudia Paiva-Santos; Francisco Veiga. "Intranasal ketoprofen nanoemulgels for brain cancer treatment: formulation development and characterization". Paper presented in XVII International CICS-UBI Symposium, 2022.
  15. Gama, Francisco; Meirinho, Sara; Patrícia C. Pires; Adriana O. Santos. "Desenvolvimento de Micro e Nanoemulsões para Entrega Intranasal de Sinvastatina em AVC". Paper presented in 16º Congresso Português do AVC, 2022.
  16. Francisca S. Nina; Patrícia C. Pires; SANTOS, ADRIANA O.. "Otimização de nanoemulsões óleo-em-água com caraterísticas ideais de composição e tamanho de gotícula". Paper presented in VI Congresso Científico Anual UBIPharma, 2020.
  17. Patrícia C. Pires; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Brain delivery of poorly soluble drugs: a proof-of-concept of phosphate esters as a way of increasing solubility and bioavailability". Paper presented in Controlled Release Society Virtual Annual Meeting, 2020.
  18. Patrícia C. Pires; Liliana T. Santos; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin - formulation development, in vitro characterization and in vivo pharmacokinetics". Paper presented in FENS 2020 Virtual Forum, 2020.
  19. Patrícia C. Pires; Ana C. Fazendeiro; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Nose-to-brain delivery of microemulsions containing phenytoin and fosphenytoin: formulation development and pharmacokinetics". Paper presented in XV Annual CICS-UBI Symposium, 2020.
  20. Dora Melo; Patrícia C. Pires; Adriana O. Santos. "A review of the clinical application of intranasal benzodiazepines in the treatment of epilepsy". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  21. Patrícia C. Pires; Márcio Rodrigues; Gilberto Alves; Adriana O. Santos. "Simultaneous quantification of phenytoin and fosphenytoin in mouse blood and brain using high-performance liquid chromatography: a tool for in vivo studies". Paper presented in 6th European Chemical Biology Symposium, 2019.
  22. Patrícia C. Pires; Liliana T. Santos; Márcio Rodrigues; Gilberto Alves; Adriana O. Santos. "Novel fosphenytoin formulations for intranasal administration - development, characterization and in vitro release studies". Paper presented in 3rd European Conference on Pharmaceutics, 2019.
  23. Liliana T. Santos; Patrícia C. Pires; SANTOS, ADRIANA O.. "Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis". Paper presented in X Beira Interior Medical Meeting, 2019.
  24. Patrícia C. Pires; Adriana O. Santos. "Brain drug delivery by intranasal nanosystems: a systematic review of pre-clinical studies". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  25. Joana Ferreira; Patrícia C. Pires; Gilberto Alves; SANTOS, ADRIANA O.. "The contribution of carbomer in pluronic-based thermoreversible gels of carbamazepine". Paper presented in 13th International Chemical and Biological Engineering Conference, 2018.
  26. Catarina Canário; Patrícia C. Pires; Mariana Matias; Vanessa de Brito; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto Alves. "Steroidal estrone oximes: cytotoxic effects on hormone-dependent cancer cell lines". Paper presented in XI Annual CICS-UBI Symposium, 2016.
Encyclopedia entry
  1. Laura Ferreira; Patrícia C. Pires; Fonseca, Mariana; Gustavo Costa; Giram, Prabhanjan S.; Mazzola, Priscila Gava; Bell, Victoria; et al. "Nanomaterials in Cosmetics". In Scholarly Community Encyclopedia, 2023. https://encyclopedia.pub/entry/42715.
    Published
Journal article
  1. Patrícia C. Pires; Mariana Magalhães; Célia Cabral; Francisco Veiga; Priscila Gava Mazzola; Ana Cláudia Paiva-Santos. "Development and characterization of novel intranasal in situ thermoreversible ketoprofen-loaded nanoemulgels for the treatment of glioblastoma". Journal of Drug Delivery Science and Technology (2025): http://dx.doi.org/10.1016/j.jddst.2025.107580.
    10.1016/j.jddst.2025.107580
  2. Matilde R. Rodrigues; Patrícia C. Pires; Ana Melero; Antonio José Guillot; Ana Borrego-Sánchez; Alina Sesarman; Manuela Banciu; Francisco Veiga; Ana Cláudia Paiva-Santos. "Anti-inflammatory drug repurposing in skin diseases: ketoprofen-loaded nanoemulsion development and characterization for topical administration". European Journal of Pharmacology (2025): http://dx.doi.org/10.1016/j.ejphar.2025.177992.
    10.1016/j.ejphar.2025.177992
  3. Pinto, Maria Beatriz; Pires, Patrícia C.; Correia, Mafalda; Gabriela Moço; Sousa-Oliveira, Inês; Sousa, Maria João; Calhelha, Ricardo C.; et al. "Propolis-Loaded Niosomes for Dermopharmaceutic and Cosmetic Applications: Development, Stability, Safety, and In Vitro Bioactivity Studies". ACS Pharmacology & Translational Science (2025): https://doi.org/10.1021/acsptsci.5c00253.
    Published • 10.1021/acsptsci.5c00253
  4. Ana Rita Pereira; Patrícia C. Pires; Huma Hameed; Daniela Lopes; Joana Lopes; Inês Sousa-Oliveira; Soraya Babaie; et al. "Injectable nanocomposite hydrogels for targeted intervention in cancer, wound healing, and bone and myocardial tissue engineering". Drug Delivery and Translational Research (2025): http://dx.doi.org/10.1007/s13346-025-01864-2.
    10.1007/s13346-025-01864-2
  5. Beatriz Couceiro; Huma Hameed; Amélia C.F. Vieira; Sachin Kumar Singh; Kamal Dua; Francisco Veiga; Patrícia C. Pires; Laura Ferreira; Ana Cláudia Paiva-Santos. "Promoting health and sustainability: exploring safer alternatives in cosmetics and regulatory perspectives". Sustainable Chemistry and Pharmacy (2025): http://dx.doi.org/10.1016/j.scp.2024.101901.
    10.1016/j.scp.2024.101901
  6. Martins, Maria; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.. "Drug Repurposing and Nanotechnology for Topical Skin Cancer Treatment: Redirecting toward Targeted and Synergistic Antitumor Effects". ACS Pharmacology & Translational Science 8 2 (2025): 308-338. https://doi.org/10.1021/acsptsci.4c00679.
    10.1021/acsptsci.4c00679
  7. Francisco Gama; Sara Meirinho; Patrícia C. Pires; Johann Tinoco; Maria Carolina Martins Gaspar; Graça Baltazar; Gilberto Alves; Santos, A. O.. "Simvastatin is delivered to the brain by high-strength intranasal cationic SMEDDS and nanoemulsions". Drug Delivery and Translational Research (2025): http://dx.doi.org/10.1007/s13346-024-01769-6.
    10.1007/s13346-024-01769-6
  8. Marta Faria; Inês Ferreira-Faria; Inês Sousa-Oliveira; Patrícia C. Pires; Huma Hameed; Fernando Silva; Gabriela Moço; et al. "Engineered biomimetic cell membrane-coated polymeric nanostructures for cancer therapy". Materials Today Chemistry (2025): http://dx.doi.org/10.1016/j.mtchem.2024.102506.
    10.1016/j.mtchem.2024.102506
  9. Gabriel Martínez-Razo; Patrícia C. Pires; Angélica Avilez-Colin; María Lilia Domínguez-López; Francisco Veiga; Eliezer Conde-Vázquez; Ana Cláudia Paiva-Santos; Armando Vega-López. "Evaluation of a Norcantharidin Nanoemulsion Efficacy for Treating B16F1-Induced Melanoma in a Syngeneic Murine Model". International Journal of Molecular Sciences (2025): https://www.mdpi.com/1422-0067/26/3/1215.
    10.3390/ijms26031215
  10. Patrícia C. Pires; Andreia Renca; Inês Amaro; Lara Parreiras; Márcia Anselmo; Maria Ferreira; Francisco Veiga; Ana Cláudia Paiva-Santos. "From stimuli-responsive polymers to nanosystems and electrocircuits: An update on the current state of polymeric hydrogel microneedles for wound healing". Journal of Drug Delivery Science and Technology (2024): http://dx.doi.org/10.1016/j.jddst.2024.106395.
    10.1016/j.jddst.2024.106395
  11. Laura Ferreira; Beatriz Torres; Huma Hameed; Amélia Vieira; Sachin Singh; Kamal Dua; Francisco Veiga; et al. "Updated insights of active cosmetic ingredients against blue light: In vivo and in vitro evidence". Journal of Drug Delivery Science and Technology (2024): http://dx.doi.org/10.1016/j.jddst.2024.106306.
    10.1016/j.jddst.2024.106306
  12. Ana Macário-Soares; Inês Sousa Oliveira; Mafalda Rodrigues Luis Correia; Patrícia C. Pires; Ankur Sharma; Dr. Niraj Kumar Jha; Ehsan Nazarzadeh Zare; et al. "Cell membrane and extracellular vesicle membrane-coated nanoparticles: An envisaged approach for the management of skin conditions". VIEW (2024): http://dx.doi.org/10.1002/viw.20240043.
    10.1002/viw.20240043
  13. Maria Beatriz S. Gonçalves; Mário Pedro Marques; Fernando Correia; Patrícia C. Pires; Mafalda Correia; Pooyan Makvandi; Carla Varela; et al. "Wine industry by-products as a source of active ingredients for topical applications". Phytochemistry Reviews (2024): http://dx.doi.org/10.1007/s11101-024-10030-4.
    10.1007/s11101-024-10030-4
  14. Patrícia C. Pires; Mahzad Motallebi; Mário Pedro Marques; Mafalda Correia; Ankur Sharma; Fouad Damiri; Huma Hameed; et al. "Mentha aquatica (Water Mint) as a Source of Active Pharmaceutical and Cosmetic Ingredients: A Critical Review". Phytotherapy Research (2024): http://dx.doi.org/10.1002/ptr.8337.
    10.1002/ptr.8337
  15. Margarida Corte-Real; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Improving Skin Cancer Treatment by Dual Drug Co-Encapsulation into Liposomal Systems—An Integrated Approach towards Anticancer Synergism and Targeted Delivery". Pharmaceutics (2024): https://www.mdpi.com/1999-4923/16/9/1200.
    10.3390/pharmaceutics16091200
  16. Joana Galvão Duarte; Filipa Mascarenhas-Melo; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Multifunctional hydrogels-based therapies for chronic diabetic wound healing". European Polymer Journal (2024): http://dx.doi.org/10.1016/j.eurpolymj.2024.113026.
    10.1016/j.eurpolymj.2024.113026
  17. Maria Beatriz Pinto; Patrícia C. Pires; Ricardo C. Calhelha; Ana Rita dos Santos Silva; Maria João Sousa; Miguel Vilas-Boas; Soraia I. Falcão; et al. "Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation". Pharmaceuticals (2024): https://www.mdpi.com/1424-8247/17/5/572.
    10.3390/ph17050572
  18. Patrícia C. Pires; Fouad Damiri; Ehsan Nazarzadeh Zare; Anwarul Hasan; Rasoul Esmaeely Neisiany; Francisco Veiga; Pooyan Makvandi; Ana Cláudia Paiva-Santos. "A review on natural biopolymers in external drug delivery systems for wound healing and atopic dermatitis". International Journal of Biological Macromolecules (2024): http://dx.doi.org/10.1016/j.ijbiomac.2024.130296.
    10.1016/j.ijbiomac.2024.130296
  19. Kamil Sghier; Maja Mur; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases". Gels (2024): https://www.mdpi.com/2310-2861/10/1/45.
    10.3390/gels10010045
  20. Joana Galvão Duarte; Dr Ankur Sharma; Esmaeel Sharifi; Fouad Damiri; Mohammed Berrada; Sachin Kumar Singh; Kamal Dua; et al. "Topical delivery of nanoemulsions for skin cancer treatment". Applied Materials Today (2023): http://dx.doi.org/10.1016/j.apmt.2023.102001.
    10.1016/j.apmt.2023.102001
  21. Eliana Veiga; Laura Ferreira; Mafalda Rodrigues Luis Correia; Patrícia C. Pires; Huma Hameed; Andre RTS Araujo; Letícia Caramori Cefali; et al. "Anti-aging peptides for advanced skincare: Focus on nanodelivery systems". Journal of Drug Delivery Science and Technology 89 (2023): 105087-105087. http://dx.doi.org/10.1016/j.jddst.2023.105087.
    10.1016/j.jddst.2023.105087
  22. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Liposome-Derived Nanosystems for the Treatment of Behavioral and Neurodegenerative Diseases: The Promise of Niosomes, Transfersomes, and Ethosomes for Increased Brain Drug Bioavailability". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/10/1424.
    10.3390/ph16101424
  23. Ana Cláudia Paiva-Santos; Tatiana Gonçalves; Diana Peixoto; Patrícia C. Pires; K. Velsankar; Niraj Kumar Jha; Vivek Chavda; et al. "Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems". Molecular Pharmaceutics 20 8 (2023): 3804-3828. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00324.
    10.1021/acs.molpharmaceut.3c00324
  24. Patrícia C. Pires; Mariana Fernandes; Francisca Nina; Francisco Gama; Maria F. Gomes; Lina E. Rodrigues; Sara Meirinho; et al. "Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/7/1878.
    10.3390/pharmaceutics15071878
  25. Beatriz P. Ferreira; Gustavo Costa; Filipa Mascarenhas-Melo; Patrícia C. Pires; Fariba Heidarizadeh; Prabhanjan S. Giram; Priscila Gava Mazzola; et al. "Skin applications of cannabidiol: sources, effects, delivery systems, marketed formulations and safety". Phytochemistry Reviews 22 3 (2023): 781-828. http://dx.doi.org/10.1007/s11101-023-09860-5.
    10.1007/s11101-023-09860-5
  26. Ana Margarida Alves; Margarida C. Gonçalves; Matilde Marques; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "In Vitro Models for Anti-Aging Efficacy Assessment: A Critical Update in Dermocosmetic Research". Cosmetics (2023): https://www.mdpi.com/2079-9284/10/2/66.
    10.3390/cosmetics10020066
  27. Omolbanin Badalkhani; Patrícia C. Pires; Maryam Mohammadi; soraya babaie; Ana Cláudia Paiva-Santos; Hamed Hamishehkar. "Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/5/670.
    10.3390/ph16050670
  28. Patrícia C. Pires; Filipa Mascarenhas-Melo; Kelly Pedrosa; Daniela Lopes; Joana Lopes; Ana Macário-Soares; Diana Peixoto; et al. "Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration". European Polymer Journal 187 (2023): 111868-111868. http://dx.doi.org/10.1016/j.eurpolymj.2023.111868.
    10.1016/j.eurpolymj.2023.111868
  29. Gabriel Martínez-Razo; Patrícia C. Pires; María Lilia Domínguez-López; Francisco Veiga; Armando Vega-López; Ana Cláudia Paiva-Santos. "Norcantharidin Nanoemulsion Development, Characterization, and In Vitro Antiproliferation Effect on B16F1 Melanoma Cells". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/4/501.
    10.3390/ph16040501
  30. Jéssica Lopes Antunes; Joana Amado; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Nanosystems, Drug Molecule Functionalization and Intranasal Delivery: An Update on the Most Promising Strategies for Increasing the Therapeutic Efficacy of Antidepressant and Anxiolytic Drugs". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/3/998.
    10.3390/pharmaceutics15030998
  31. Laura Ferreira; Patrícia C. Pires; Mariana Fonseca; Gustavo Costa; Dr. Prabhanjan Giram; Priscila Mazzola; victoria bell; et al. "Nanomaterials in Cosmetics: An Outlook for European Regulatory Requirements and a Step Forward in Sustainability". Cosmetics (2023): https://www.mdpi.com/2079-9284/10/2/53.
    10.3390/cosmetics10020053
  32. Maria Daniela Ferreira; Joana Duarte; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Nanosystems for Brain Targeting of Antipsychotic Drugs: An Update on the Most Promising Nanocarriers for Increased Bioavailability and Therapeutic Efficacy". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/2/678.
    10.3390/pharmaceutics15020678
  33. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Nano and Microemulsions for the Treatment of Depressive and Anxiety Disorders: An Efficient Approach to Improve Solubility, Brain Bioavailability and Therapeutic Efficacy". Pharmaceutics 14 12 (2022): 2825-2825. http://dx.doi.org/10.3390/pharmaceutics14122825.
    10.3390/pharmaceutics14122825
  34. Margarida Alberto; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders". Pharmaceutics 14 12 (2022): 2742-2742. http://dx.doi.org/10.3390/pharmaceutics14122742.
    10.3390/pharmaceutics14122742
  35. Joana Lopes; Daniela Lopes; Ana Macário-Soares; Inês Ferreira-Faria; Diana Peixoto; Mahzad Motallebi; Imran Mohammad; et al. "Cell Membrane-Coated Biomaterials for Bone Cancer-Targeted Diagnosis and Therapy: A Critical Update on Osteosarcoma Applications". Materials Chemistry Horizons (2022): https://doi.org/10.22128/mch.2022.615.1032.
    10.22128/mch.2022.615.1032
  36. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Antipsychotics-Loaded Nanometric Emulsions for Brain Delivery". Pharmaceutics 14 10 (2022): 2174-2174. http://dx.doi.org/10.3390/pharmaceutics14102174.
    10.3390/pharmaceutics14102174
  37. Pires, Patrícia C.; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs". Pharmaceutics 14 3 (2022): 588. https://doi.org/10.3390/pharmaceutics14030588.
    10.3390/pharmaceutics14030588
  38. Canário, Catarina; Matias, Mariana; Brito, Vanessa; Pires, Patrícia; Santos, Adriana O.; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. "C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies". Applied Sciences 12 7 (2022): 3579. https://doi.org/10.3390/app12073579.
    10.3390/app12073579
  39. Pires, Patrícia C.; Fazendeiro, Ana C.; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.". European Journal of Pharmaceutical Sciences 164 (2021): 105918. https://doi.org/10.1016/j.ejps.2021.105918.
    10.1016/j.ejps.2021.105918
  40. Pires, Patrícia C.; Santos, Liliana T.; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Intranasal fosphenytoin: The promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs". International Journal of Pharmaceutics 592 (2021): 120040. https://doi.org/10.1016/j.ijpharm.2020.120040.
    10.1016/j.ijpharm.2020.120040
  41. Pires, Patrícia C.; Peixoto, Diana; Teixeira, Isaura; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization". European Journal of Pharmaceutical Sciences 141 (2020): 105099. https://doi.org/10.1016/j.ejps.2019.105099.
    10.1016/j.ejps.2019.105099
  42. Pires, Patrícia C.; Santos, Adriana O.. "Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies". Journal of Controlled Release 270 (2018): 89-100. https://doi.org/10.1016/j.jconrel.2017.11.047.
    10.1016/j.jconrel.2017.11.047
Online resource
  1. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. Nanosystems for Brain Drug Delivery. 2022. https://encyclopedia.pub/entry/33306.
  2. Margarida Alberto; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. Lipid and Polymeric Nanoparticles for Brain Drug Delivery. 2022. https://encyclopedia.pub/entry/38768.
  3. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. Nano and Microemulsions for Depression and Anxiety Treatment. 2022. https://encyclopedia.pub/entry/39040.

Intellectual property

Patent
  1. SANTOS, ADRIANA O.; Mariana Carvalho Fernandes; Patrícia C. Pires; Alves, Gilberto; Ana Carolina Maricoto Fazendeiro; Francisca Matos Silva Pereira Nina; Maria De Fátima da Silva Ferreira Gomes; Rodrigues, Lina. 2021. "Emulsão homogénea para entrega de agentes ativos, seus métodos e usos/ Self-emulsifying composition, production methods and uses thereof".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11 Intranasal administration of fosphenytoin: assay development and validation and preliminary in vivo pharmacokinetic studies III International Congress in Health Sciences Research
(Covilhã, Portugal)
2019/07 Formulation development and in vitro characterization of nanoemulsions and nanoemulgels of phenytoin and fosphenytoin for intranasal administration XIV Annual CICS-UBI Symposium
(Covilhã, Portugal)
2018/07 Thermosensitive and mucoadhesive polymers in intranasal drug delivery: fosphenytoin formulation development and characterization XIII Annual CICS-UBI Symposium
(Covilhã, Portugal)
2017 Modifications of estrone in C- and D-ring: synthesis, biological evaluation and docking studies XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - 2021 Eficácia da administração intranasal de micro e nanoemulsões na biodisponibilidade e direcionamento cerebral de fármacos de baixa massa molecular
Co-supervisor
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2020 - 2021 Otimização de nanoemulsões óleo-em-água com caraterísticas ideais de composição e tamanho de gotícula
Co-supervisor
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2019 - 2021 Formulação de emulsões nanométricas de fenitoina e fosfenitoina
Co-supervisor of Ana C. Fazendeiro
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2019 - 2020 Revisão de modelos de epitélio nasal humano nos estudos pré-clínicos de segurança
Co-supervisor of Iryna Denysyuk
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018 - 2019 Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis
Co-supervisor of Liliana T. Santos
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018 - 2019 Revisão da aplicação clínica de benzodiazepinas pela via intranasal no tratamento da epilepsia
Co-supervisor of Dora Melo
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Distinctions

Award

2019 Best Oral Communication in the "III International Congress in Health Sciences Research", Covilhã, Portugal
Universidade da Beira Interior Instituto Coordenador da Investigação, Portugal