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Identification

Personal identification

Full name
FREDERICO SIMÕES DO COUTO DE OLIVEIRA FERNANDES

Author identifiers

Ciência ID
D117-0296-8086
Education
Degree Classification
2016/07/21
Concluded
 Doutoramento Psiquiatria e Saúde Mental (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"Is depression a risk factor for dementia? (a translational study)" (THESIS/DISSERTATION)
 Honors and distinction
2015
Concluded
 Competência em Geriatria (Geriatrics) (Título de especialista)
Ordem dos Médicos, Portugal

Portuguese Medical Board, Portugal
2000/01/01 - 2005/02/12
Concluded
 Psychiatry (Título de especialista)
Hospital de Santa Maria, Portugal
 19,5/20
1997/09/09
Concluded
 Medicina (Licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2022/02/25 - Current Researcher (Research) Universidade Católica Portuguesa Centro de Investigação Interdisciplinar em Saúde, Portugal
2006/01/01 - 2022/02/24 Invited Auxiliary Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015/01/01 - 2022/01/31 Invited Auxiliary Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/09/01 - Current Invited Assistant Professor (University Teacher) Universidade Católica Portuguesa, Portugal
Universidade Católica Portuguesa - Faculdade de Medicina, Portugal
2017/05/01 - 2021/08/31 Invited Assistant Professor (University Teacher) Universidade de Lisboa, Portugal
1998 - 2017/06/30 Invited Assistant (University Teacher) Universidade de Lisboa, Portugal

Other Careers

Category
Host institution 		Employer
2015/01/01 - Current Assistente graduado (Médica) Hospital de Santa Maria, Portugal
Hospital de Santa Maria, Portugal
2005/02/14 - 2015/12/01 Assistente (Médica) Hospital de Santa Maria, Portugal
Hospital de Santa Maria, Portugal
2000/01/01 - 2005/02/12 Interno (Médica) Hospital de Santa Maria, Portugal
Hospital de Santa Maria, Portugal
Outputs

Publications

Book chapter
  1. Couto, F.S.D.; Mendonça, A.D.. "Aging and cognitive decline: Neuroprotective strategies". 245-268. 2007.
Conference paper
  1. Silva, Bruno; Guerreiro, Cláudia; C. Crespo, Ângela; Marques, Liliana; Marcelino, Erica; Maruta, Carolina; Costa, Sónia; et al. "Decrease of ß-amyloid peptide precursor and ceruloplasmin mRNA levels in patients with Alzheimer’s disease support impairment of cellular iron efflux in this pathology". 2014.
  2. C. Crespo, Ângela; Marques, Liliana; Marcelino, Erica; Maruta, Carolina; Costa, Sónia; Timóteo, Ângela; Vilares, Arminda; et al. "Iron/copper metabolism in Alzheimer’s disease: genetics and biomarkers in a Portuguese population". 2012.
Conference poster
  1. Neves, O.; Eggenkamp, Hans G.M.; José Manuel Vaz Velho Barbosa Marques; Inês Machete; Frederico Simões do Couto. ""The magic (?) ion in Portuguese drinking water: preliminary results"". Paper presented in 6th International Conference on Medical Geology (MEDGEO15), 2015.
Journal article
  1. Joana Teixeira; Maria Pinheiro; Gabriela Álvares Pereira; Paulo Nogueira; Manuela Guerreiro; Miguel Castanho; Frederico Simões do Couto. "Predicting alcohol relapse post-detoxification: The role of cognitive impairments in alcohol use disorder patients". Alcohol, Clinical and Experimental Research (2024): http://dx.doi.org/10.1111/acer.15302.
    10.1111/acer.15302
  2. Rainer Schaefert; Barbara Stein; Gunther Meinlschmidt; Noa Roemmel; Jordi Blanch; Birgitte Boye; Eduardo Carqueja; et al. "COVID-19-related consultation-liaison (CL) mental health services in general hospitals". Journal of Psychosomatic Research 167 (2023): https://ciencia.ucp.pt/en/publications/450b5b34-f66e-4026-984f-fc608f3b2e2d.
    10.1016/j.jpsychores.2023.111183
  3. João Paulo Rema; Frederico Simões do Couto. "Aducanumab na Doença de Alzheimer: Percurso e Perspetiva". Revista Portuguesa de Psiquiatria e Saúde Mental (2022): https://doi.org/10.51338/rppsm.308.
    10.51338/rppsm.308
  4. Tiago Mendes; Sandra Cardoso; Manuela Guerreiro; João Maroco; Dina Silva; Luísa Alves; Ben Schmand; et al. "Memory awareness in patients with Major Depressive Disorder". Journal of Psychiatric Research 137 (2021): 411-418. https://doi.org/10.1016/j.jpsychires.2021.03.016.
    10.1016/j.jpsychires.2021.03.016
  5. Andrade, Gabriela; Simões do Couto, Frederico; Câmara-Pestana, Luis. "Recomendações sobre a Utilização de Fármacos Psicotrópicos durante a Pandemia COVID-19". Acta Médica Portuguesa 33 10 (2020): 693. http://dx.doi.org/10.20344/amp.13976.
    10.20344/amp.13976
  6. Martinho, Filipe Peste; Duarte, Gonçalo Silva; Simões do Couto, Frederico. "Efficacy, Effect on Mood Symptoms, and Safety of Deep Brain Stimulation in Refractory Obsessive-Compulsive Disorder". The Journal of Clinical Psychiatry 81 3 (2020): http://dx.doi.org/10.4088/jcp.19r12821.
    10.4088/jcp.19r12821
  7. Vacas, S.M.; Stella, F.; Loureiro, J.C.; Simões do Couto, F.; Oliveira-Maia, A.J.; Forlenza, O.V.. "Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta-analysis". International Journal of Geriatric Psychiatry 34 9 (2019): 1336-1345. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055165423&partnerID=MN8TOARS.
    10.1002/gps.5003
  8. Verheijen, J.; van der Zee, J.; Gijselinck, I.; Van den Bossche, T.; Dillen, L.; Heeman, B.; Gómez-Tortosa, E.; et al. "Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort". Neurobiology of Aging 62 (2018): 245.e1-245.e7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035129689&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2017.10.012
  9. Baradaran-Heravi, Y.; Dillen, L.; Nguyen, H.P.; Van Mossevelde, S.; Baets, J.; De Jonghe, P.; Engelborghs, S.; et al. "No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients". Neurobiology of Aging 69 (2018): 293.e9-293.e11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048725744&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2018.05.005
  10. Duarte, Tiago A.; Godinho, Filipe D. G.; Ferreira, André L. B.; Couto, Frederico Simões do; Martins, Paulo T.; Duarte, T.A.; Godinho, F.D.G.; et al. "Clozapine-Induced Procalcitonin Elevation". The Primary Care Companion For CNS Disorders 19 3 (2017): http://dx.doi.org/10.4088/pcc.16l02054.
    10.4088/pcc.16l02054
  11. van der Zee J; Gijselinck I; Van Mossevelde S; Perrone F; Dillen L; Heeman B; Bäumer V; et al. "TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.". (2017): http://europepmc.org/abstract/med/28008748.
    10.1002/humu.23161
  12. De Roeck, A.; Van den Bossche, T.; van der Zee, J.; Verheijen, J.; De Coster, W.; Van Dongen, J.; Dillen, L.; et al. "Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer’s disease". Acta Neuropathologica 134 3 (2017): 475-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018272631&partnerID=MN8TOARS.
    10.1007/s00401-017-1714-x
  13. Simões do Couto F; Lunet N; Ginó S; Chester C; Freitas V; Maruta C; Figueira ML; de Mendonça A. "Depression with melancholic features is associated with higher long-term risk for dementia.". (2016): http://europepmc.org/abstract/med/27267294.
    10.1016/j.jad.2016.05.026
  14. Gonçalves-Ferreira A; do Couto FS; Rainha Campos A; Lucas Neto LP; Gonçalves-Ferreira D; Teixeira J. "Deep Brain Stimulation for Refractory Cocaine Dependence.". (2016): http://europepmc.org/abstract/med/26235303.
    10.1016/j.biopsych.2015.06.023
  15. Guerreiro C; Silva B; Crespo ÂC; Marques L; Costa S; Timóteo Â; Marcelino E; et al. "Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients.". (2015): http://europepmc.org/abstract/med/26209012.
    10.1016/j.bbadis.2015.07.017
  16. Braz, M.I.S.; Couto, F.; Pestana, L.C.. "HIV-associated psychosis versus Schizophrenia,Psicose secundária ao HIV versus Esquizofrenia". Sinapse 15 2 (2015): 19-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971597261&partnerID=MN8TOARS.
  17. Neves, O.; Machete, I.; Marques, J.M.; da Silva, J.A.L.; Simões do Couto, F.. "Lithium in bottled and tap Portuguese waters,Lítio em águas engarrafadas e de abastecimento público portuguesas". Comunicacoes Geologicas 102 Special Is (2015): 103-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021816530&partnerID=MN8TOARS.
  18. van der Zee J; Van Langenhove T; Kovacs GG; Dillen L; Deschamps W; Engelborghs S; Matej R; et al. "Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.". (2014): http://europepmc.org/abstract/med/24899140.
    10.1007/s00401-014-1298-7
  19. Ângela C. Crespo; Bruno Silva; Liliana Marques; Erica Marcelino; Carolina Maruta; Sónia Costa; Ângela Timóteo; et al. "Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation". Neurobiology of Aging 35 4 (2014): 777-785. https://doi.org/10.1016/j.neurobiolaging.2013.10.078.
    10.1016/j.neurobiolaging.2013.10.078
  20. Coelho JE; Alves P; Canas PM; Valadas JS; Shmidt T; Batalha VL; Ferreira DG; et al. "Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.". (2014): http://europepmc.org/abstract/med/24982640.
    10.3389/fpsyt.2014.00067
  21. Couto FS; Batalha VL; Valadas JS; Data-Franca J; Ribeiro JA; Lopes LV. "Escitalopram improves memory deficits induced by maternal separation in the rat.". (2012): http://europepmc.org/abstract/med/22981666.
    10.1016/j.ejphar.2012.08.020
  22. Do Couto, F.S.; Queiroz, C.; Barbosa, T.; Ferreira, L.; Firmino, H.; Viseu, M.; Ramos, L.; Romero, J.; Figueira, M.L.. "Clinical and therapeutic characterization of a Portuguese sample of patients with schizophrenia,Caracterización clínica y terapéutica de un muestreo portugués de paeientes con esquizofrenia". Actas Espanolas de Psiquiatria 39 3 (2011): 147-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961052714&partnerID=MN8TOARS.
  23. Simões do Couto F; Queiroz C; Barbosa T; Ferreira L; Firmino H; Viseu M; Ramos L; et al. "Clinical and therapeutic characterization of a Portuguese sample of patients with schizophrenia.". (2011): http://europepmc.org/abstract/med/21560074.
  24. do Couto FS. "Medical care and long-term treatment of patients with schizophrenia: ethical concerns.". (2010): http://europepmc.org/abstract/PMC/PMC2991989.
  25. Pereira AF; Simões do Couto F; de Mendonça A; Pereira, A.F.; Do Couto, F.S.; De Mendonça, A.. "The use of laboratory tests in patients with mild cognitive impairment.". Journal of Alzheimer's Disease 10 1 (2006): 53-58. http://europepmc.org/abstract/med/16988482.
    10.3233/JAD-2006-10109
  26. Simoes do Couto, F.; De Mendonca, A.; Garcia, C.; Rocha, L.; Lechner, M.C.; do Couto FS; de Mendonça A; et al. "Age of onset in patients with Alzheimer's disease with different apoE genotypes [1]". Journal of Neurology Neurosurgery and Psychiatry 64 6 (1998): 817-817. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031798827&partnerID=MN8TOARS.
    10.1136/jnnp.64.6.817
  27. Vale FM; Castro M; Monteiro J; Couto FS; Pinto R; Gião Toscano Rico JM; Vale, F.M.; et al. "Acrylic bone cement induces the production of free radicals by cultured human fibroblasts.". Biomaterials 18 16 (1997): 1133-1135. http://europepmc.org/abstract/med/9247352.
    10.1016/s0142-9612(97)00043-4
Thesis / Dissertation
  1. Machado, Beatriz Costa Pinto. "Versão curta do Mini Mental State Examination (NMSE) para screening de defeito cognitivo ligeiro (DCL)". Master, 2019. http://hdl.handle.net/10451/40348.
  2. Fernandes, Frederico Simões do Couto de Oliveira, 1973-. "Is depression a risk factor for dementia? : a translational research". PhD, 2016. http://hdl.handle.net/10451/26277.
  3. Sampaio, Inês dos Reis. "Deep brain stimulation : what is the relation between the acute clinical effects and the efficacy outcomes in obsessive-compulsive disorder? : estimulação cerebral profunda : qual a relação entre os efeitos clínicos agudos e os resultados de eficácia?". Master, 2015. http://hdl.handle.net/10451/25337.

Other

Other output
  1. Diminuição da expressão dos genes APP e CP em doentes de Alzheimer sugere alteração da exportação de ferro celular nesta demência. Recentemente tem-se assistido a um acumular de evidência sugerindo a implicação de uma desregulação do metabolismo do ferro (Fe) na fisiopatologia da doença de Alzheimer (DA). Neste trabalho, pretendemos esclarecer melhor os mecanismos moleculares subjacentes à homeostasia deste metal na DA, particularmente ao nível do efluxo celular. Assim, mediu-se em células mononucleares do sangue periférico d. 2016. Cláudia, Guerreiro; Bruno, Silva; Crespo, Ângela C.; Marques, Liliana; Costa, Sónia; Timóteo, Ângela; Marcelino, Erica; et al. http://hdl.handle.net/10400.18/3898.
  2. Cognitive deficits in middle-aged and older adults with bipolar disorder and cognitive complaints: Comparison with mild cognitive impairment. Objective Cognitive impairment has been reported in elderly bipolar disorder (BD) patients, however, few studies have evaluated middle-aged and older BD patients using standardized cognitive assessments and none (to our knowledge) analysed middle-aged and older BD patients with recent cognitive complaints. The main objective of this study is to characterize the cognitive deficits of middle-aged an. 2009. Silva, Dina Lúcia Gomes da; Santana, Isabel; Couto, Frederico Simões do; Maroco, João; Guerreiro, Manuela; Mendonça, Alexandre de. http://hdl.handle.net/10400.12/2645.
    10.1002/gps.2166
Activities

Association member

Society Organization name Role
2022/11/30 - Current Biological Psychiatry Section (Portuguese Society of Psychiatry and Mental Health)
1998/06/12 - Current Grupo de Estudos de Envelhecimento Cerebral e Demência