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Identification

Personal identification

Full name
Maria Helena Pereira Tavares de Sousa

Citation names

  • Sousa, Helena
  • Tavares de Sousa H
  • Sousa, HT

Author identifiers

Ciência ID
CF1F-1163-1C4A
ORCID iD
0000-0002-6626-205X

Email addresses

  • maria.t.sousa@chalgarve.min-saude.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Gastroenterology and hepatology
Education
Degree Classification
2020/06 - 2024/07/08
Concluded
Medicina (Doutoramento)
Major in Gastrenterologia
Universidade do Porto Faculdade de Medicina, Portugal
"Are Crohn´s disease phenotypes a myth? A histopathological study on transmural and inflammation in ileal Crohn´s disease " (THESIS/DISSERTATION)
Aprovada
1994 - 2000
Concluded
Medicina (Licenciatura)
Major in Gastrenterologia
Universidade de Coimbra, Portugal
16.33
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2025/07/23 - Current Assistant Professor (University Teacher) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2012/09 - 2024 Invited Assistant (University Teacher) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Other Careers

Category
Host institution
Employer
2018/02 - Current Assistente graduado (Médica) Unidade Local de Saúde do Algarve, Portugal
2010/01/01 - 2018/02 Assistente (Médica) Unidade Local de Saúde do Algarve, Portugal

Positions / Appointments

Category
Host institution
Employer
2019/01/01 - Current Coordenador Unidade de Portimao do Serviço de Gastrenterologia Unidade Local de Saúde do Algarve, Portugal
Outputs

Publications

Conference abstract
  1. Magro, F; Rocha, C; Vieira, AI; Sousa, HT; Rosa, I; Lopes, S; Carvalho, J; Dias, CC; Afonso, J. "The new biosimilar of infliximab SB2 can be quantified by IFX-optimised therapeutic drug monitoring assays". 2018.
  2. Portela, F; Ministro, P; Dias, C; Caldeira, P; Cravo, ML; Deus, J; Goncalves, R; et al. "Complementary and Alternative Medicine (CAM) in Inflammatory Bowel Diseases (IBD) - Why, Who and What". 2012.
Journal article
  1. Helena Tavares de Sousa; Raquel Oliveira. "Serum Biomarkers of Extracellular Matrix Remodeling in Ulcerative Colitis—One Step Closer to Fibrosis Biomarkers in Inflammatory Bowel Disease". United European Gastroenterology Journal (2025): https://doi.org/10.1002/ueg2.12770.
    10.1002/ueg2.12770
  2. D. Magalhaes; M. Santiago; M. Patita; B. Arroja; P. Lago; I. Rosa; H. T. Sousa; et al. "Serum Neutrophil Biomarkers to Predict Crohn's Disease Progression and Infliximab Treatment Outcomes". United European Gastroenterology Journal (2024): https://doi.org/10.1002/ueg2.12712.
    10.1002/ueg2.12712
  3. Raquel Oliveira; Viviana Martins; Laetitia Teixeira; Helena Tavares de Sousa; Joana Roseira. "Food-Related Quality of Life in Inflammatory Bowel Disease: Translation and Validation of Food-Related Quality of Life to the Portuguese Language (FR-QoL-29-Portuguese)". GE - Portuguese Journal of Gastroenterology (2024): https://doi.org/10.1159/000539227.
    10.1159/000539227
  4. Fernando Magro; Maria Manuela Estevinho; Gaia Catalano; Marta Patita; Bruno Arroja; Paula Lago; Isadora Rosa; et al. "How many biomarker measurements are needed to predict prognosis in Crohn's disease patients under infliximab?—A prospective study". United European Gastroenterology Journal (2023): https://doi.org/10.1002/ueg2.12420.
    10.1002/ueg2.12420
  5. Helena Tavares de Sousa; Fernando Magro. "How to Evaluate Fibrosis in IBD?". Diagnostics (2023): https://doi.org/10.3390/diagnostics13132188.
    10.3390/diagnostics13132188
  6. João A Cunha Neves; Joana Roseira; Patrícia Queirós; Helena Tavares Sousa; Gianluca Pellino; Miguel F Cunha. "Targeted intervention to achieve waste reduction in gastrointestinal endoscopy". Gut (2023): https://doi.org/10.1136/gutjnl-2022-327005.
    10.1136/gutjnl-2022-327005
  7. Samuel Fernandes; Juliana Serrazina; Inês Ayala Botto; Tiago Leal; Andreia Guimarães; Joana Lemos Garcia; Isadora Rosa; et al. "Transmural remission improves clinical outcomes up to 5 years in Crohn's disease". United European Gastroenterology Journal 11 1 (2023): 51-59. http://dx.doi.org/10.1002/ueg2.12356.
    10.1002/ueg2.12356
  8. Helena Tavares de Sousa; Fátima Carneiro. "Understanding progression of strictures in ileal Crohn's disease—The importance of setting methodological standards". United European Gastroenterology Journal (2022): https://doi.org/10.1002/ueg2.12327.
    10.1002/ueg2.12327
  9. Fernando Magro; Diogo Magalhães; Marta Patita; Bruno Arroja; Paula Lago; Isadora Rosa; Helena Tavares de Sousa; et al. "Subclinical Persistent Inflammation as Risk Factor for Crohn's Disease Progression: Findings From a Prospective Real-World Study of 2 Years". Clinical Gastroenterology and Hepatology 20 9 (2022): 2059-2073.e7. http://dx.doi.org/10.1016/j.cgh.2021.12.004.
    10.1016/j.cgh.2021.12.004
  10. Helena Tavares de Sousa; Irene Gullo; Fernando Magro. "Fibromuscular Expansion in Crohn’s Disease Ileal Strictures: An Open Issue". Clinical Gastroenterology and Hepatology (2022): http://dx.doi.org/10.1016/j.cgh.2022.06.023.
    10.1016/j.cgh.2022.06.023
  11. João A. Cunha Neves; Joana Roseira; Patrícia Queirós; Helena Tavares de Sousa. "Comment on “The Effect of Hyperbaric Oxygen Therapy on Rectal Ulcers after Argon Plasma Coagulation”". GE - Portuguese Journal of Gastroenterology 29 2 (2022): 80-81. https://doi.org/10.1159/000520227.
    10.1159/000520227
  12. João A. Cunha Neves; Joana Roseira; Helena Tavares de Sousa; Rui Machado. "Exploring the Ways of “The Great Imitator”: A Case Report of Syphilitic Hepatitis". GE - Portuguese Journal of Gastroenterology (2021): 1-4. https://doi.org/10.1159/000516944.
    10.1159/000516944
  13. Sousa, Helena. "Ileal Crohn's Disease Exhibits Similar Transmural Fibrosis Irrespective of Phenotype.". Clinical and translational gastroenterology (2021): https://europepmc.org/articles/PMC8049162.
    10.14309/ctg.0000000000000330
  14. "Short Inflammatory Bowel Disease Questionnaire: translation and validation to the Portuguese language.". Health and quality of life outcomes (2021): https://europepmc.org/articles/PMC7891007.
    10.1186/s12955-021-01698-9
  15. "Histologic Features of Colon Biopsies (Geboes Score) Associated With Progression of Ulcerative Colitis for the First 36 Months After Biopsy.". Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (2020): https://doi.org/10.1016/j.cgh.2020.09.017.
    10.1016/j.cgh.2020.09.017
  16. Sousa, Helena. "The new simplified MARIA score applies beyond clinical trials: A suitable clinical practice tool for Crohn’s disease that parallels a simple endoscopic index and fecal calprotectin". United European Gastroenterology Journal (2020): http://dx.doi.org/10.1177/2050640620943089.
    10.1177/2050640620943089
  17. Sousa, Helena. "Methylation patterns in dysplasia in inflammatory bowel disease patients". Scandinavian Journal of Gastroenterology (2020): http://dx.doi.org/10.1080/00365521.2020.1766552.
    10.1080/00365521.2020.1766552
  18. Sousa, Helena. "Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and their Relation to Faecal Calprotectin Levels.". Journal of Crohn's & colitis (2020): https://doi.org/10.1093/ecco-jcc/jjz123.
    10.1093/ecco-jcc/jjz123
  19. Sousa, Helena. "Transmural Histological Scoring Systems in Crohn's Disease: A Systematic Review With Assessment of Methodological Quality and Operating Properties.". Journal of Crohn's & colitis (2020): https://doi.org/10.1093/ecco-jcc/jjz178.
    10.1093/ecco-jcc/jjz178
  20. Sousa, Helena. "Serum Dipeptidyl Peptidase 4: A Predictor of Disease Activity and Prognosis in Inflammatory Bowel Disease.". Inflammatory bowel diseases (2020): https://doi.org/10.1093/ibd/izz319.
    10.1093/ibd/izz319
  21. "Delayed Intramural Duodenal Hematoma After a Simple Diagnostic Endoscopic Ultrasonography Fine-Needle Aspiration Procedure". ACG Case Reports Journal 6 11 (2019): e00279-e00279. http://dx.doi.org/10.14309/crj.0000000000000279.
    10.14309/crj.0000000000000279
  22. Sousa, Helena. "Low Golimumab Trough Levels at Week 6 Are Associated With Poor Clinical, Endoscopic and Histological Outcomes in Ulcerative Colitis Patients: Pharmacokinetic and Pharmacodynamic Sub-analysis of the Evolution Study". Journal of Crohn's and Colitis (2019): http://dx.doi.org/10.1093/ecco-jcc/jjz071.
    10.1093/ecco-jcc/jjz071
  23. Sousa, Helena. "Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab.". Therapeutic Advances in Gastroenterology (2019): https://europepmc.org/articles/PMC6719471.
    10.1177/1756284819869141
  24. Sousa, Helena. "Sexual Quality of Life in Inflammatory Bowel Disease: A Multicenter, National-Level Study.". Inflammatory bowel diseases (2019): https://doi.org/10.1093/ibd/izz185.
    10.1093/ibd/izz185
  25. Sousa, Helena. "The performance of Remicade®-optimized quantification assays in the assessment of Flixabi® levels.". Therapeutic Advances in Gastroenterology (2018): https://europepmc.org/articles/PMC6153527.
    10.1177/1756284818796956
  26. Sousa, Helena. "New cross-sectional imaging in IBD.". Current opinion in gastroenterology (2018): https://doi.org/10.1097/MOG.0000000000000440.
    10.1097/mog.0000000000000440
  27. Sousa, Helena. "Editorial: ulcerative colitis submucosal fibrosis and inflammation: more than just strictures". Alimentary Pharmacology & Therapeutics (2018): http://dx.doi.org/10.1111/apt.14575.
    10.1111/apt.14575
  28. Sousa, Helena. "Comparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels.". Gut (2018): https://doi.org/10.1136/gutjnl-2017-315545.
    10.1136/gutjnl-2017-315545
  29. Sousa, Helena. "Corrigendum: Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management.". Journal of Crohn's & colitis (2017): https://doi.org/10.1093/ecco-jcc/jjx105.
    10.1093/ecco-jcc/jjx105
  30. Sousa, Helena. "Therapeutic drug monitoring of CT-P13: a comparison of four different immunoassays.". Therapeutic Advances in Gastroenterology (2017): https://europepmc.org/articles/PMC5598811.
    10.1177/1756283X17722915
  31. Sousa, Helena. "Clinical performance of an infliximab rapid quantification assay.". Therapeutic Advances in Gastroenterology (2017): https://europepmc.org/articles/PMC5598812.
    10.1177/1756283X17722916
  32. Sousa, Helena. "Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management.". Journal of Crohn's & colitis (2017): https://doi.org/10.1093/ecco-jcc/jjx009.
    10.1093/ecco-jcc/jjx009
  33. Sousa, Helena. "Calprotectin and the Magnitude of Antibodies to Infliximab in Clinically-stable Ulcerative Colitis Patients are More Relevant Than Infliximab Trough Levels and Pharmacokinetics for Therapeutic Escalation.". EBioMedicine (2017): https://europepmc.org/articles/PMC5514398.
    10.1016/j.ebiom.2017.06.004
  34. Sousa, Helena. "Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocalin in Evaluating Subclinical Inflammation in UlceRaTIVE Colitis-the ACERTIVE study.". Journal of Crohn's & colitis (2017): https://doi.org/10.1093/ecco-jcc/jjw170.
    10.1093/ecco-jcc/jjw170
  35. Sousa, Helena. "Erratum: Development and Validation of Risk Matrices for Crohn's Disease Outcomes in Patients Who Underwent Early Therapeutic Interventions.". Journal of Crohn's & colitis (2017): https://doi.org/10.1093/ecco-jcc/jjw207.
    10.1093/ecco-jcc/jjw207
  36. Sousa, Helena. "Development and Validation of Risk Matrices for Crohn's Disease Outcomes in Patients Who Underwent Early Therapeutic Interventions.". Journal of Crohn's & colitis (2017): https://doi.org/10.1093/ecco-jcc/jjw171.
    10.1093/ecco-jcc/jjw171
  37. "The who-when-why triangle of complementary and alternative medicine use among Portuguese IBD patients". Digestive and Liver Disease 49 4 (2017): 388-396. http://dx.doi.org/10.1016/j.dld.2016.12.031.
    10.1016/j.dld.2016.12.031
  38. Sousa, Helena. "Impact of Early Surgery and Immunosuppression on Crohn's Disease Disabling Outcomes.". Inflammatory bowel diseases (2017): https://doi.org/10.1097/MIB.0000000000001007.
    10.1097/mib.0000000000001007
  39. Sousa, Helena. "Proactive therapeutic drug monitoring of infliximab: a comparative study of a new point-of-care quantitative test with two established ELISA assays.". Alimentary pharmacology & therapeutics (2016): https://doi.org/10.1111/apt.13757.
    10.1111/apt.13757
  40. Sousa, Helena. "Detection of anti-infliximab antibodies is impacted by antibody titer, infliximab level and IgG4 antibodies: a systematic comparison of three different assays.". Therapeutic Advances in Gastroenterology (2016): https://europepmc.org/articles/PMC5076767.
    10.1177/1756283X16658223
  41. "Anaemia in Patients with Inflammatory Bowel Disease - A Nationwide Cross-Sectional Study". Digestion 93 3 (2016): 214-220. http://dx.doi.org/10.1159/000443927.
    10.1159/000443927
  42. Sousa, Helena. "Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country.". Journal of gastrointestinal and liver diseases : JGLD (2014): https://doi.org/10.15403/jgld.2014.1121.234.hrq.
    10.15403/jgld.2014.1121.234.hrq
  43. Sousa, Helena. "Primary squamous cell carcinoma of the most distal rectum: a dilemma in origin and management.". BMJ case reports (2014): https://europepmc.org/articles/PMC3987253.
    10.1136/bcr-2013-201156
  44. Sousa, Helena. "Upper gastrointestinal bleeding in cirrhosis: varix or no varix?". BMJ case reports (2013): https://europepmc.org/articles/PMC3736272.
    10.1136/bcr-2013-008815
  45. Sousa, Helena. "Gastric pneumatosis: a radiological diagnosis with a wide clinical spectrum.". Endoscopy (2012): https://doi.org/10.1055/s-0032-1325895.
    10.1055/s-0032-1325895
  46. "Ulcerative colitis in northern Portugal and Galicia in Spain.". Inflammatory bowel diseases (2010): https://doi.org/10.1002/ibd.21170.
    10.1002/ibd.21170
  47. "Clinical practice in Crohn's disease in bordering regions of two countries: different medical options, distinct surgical events.". Journal of Crohn's & colitis (2010): https://doi.org/10.1016/j.crohns.2009.12.004.
    10.1016/j.crohns.2009.12.004
  48. "Crohn's disease in a southern European country: Montreal classification and clinical activity.". Inflammatory bowel diseases (2009): https://doi.org/10.1002/ibd.20901.
    10.1002/ibd.20901
  49. Sousa, Helena. "Primary leiomyoma of the liver: accurate preoperative diagnosis on liver biopsy.". BMJ case reports (2009): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21686574/?tool=EBI.
    10.1136/bcr.09.2008.0898
  50. "Posttransplant lymphoproliferative disorders in patients with IBD on immunosuppressive treatment.". Inflammatory bowel diseases (2009): https://doi.org/10.1002/ibd.20634.
    10.1002/ibd.20634
  51. Sousa, Helena. "Hemobilia due to pseudoaneurysm of the cystic artery.". Gastroenterologie clinique et biologique (2008): https://doi.org/10.1016/j.gcb.2008.10.010.
    10.1016/j.gcb.2008.10.010
  52. Sousa, Helena. "Successful endoscopic banding after cyanoacrylate failure for active bleeding duodenal varix.". Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva (2008): https://doi.org/10.4321/s1130-01082008000300008.
    10.4321/s1130-01082008000300008
  53. Sousa, Helena. "Endoscopic resection of ampullary carcinoma.". Endoscopy (2006): https://doi.org/10.1055/s-2006-925039.
    10.1055/s-2006-925039