Hugo Agostinho Machado Fernandes (CE15-5259-CC1D)

Curriculum Vitae

Hugo Agostinho Machado Fernandes

Hugo Fernandes (HF) obtained his Applied Biology degree from the University of Minho (Portugal), following an internship at the Faculty of Medicine, University Complutense Madrid (Spain), under the guidance of Prof. J Regueiro. After graduating, HF joined the group of Prof. C van Blitterswijk and Prof. J de Boer at the University of Twente (Netherlands), where he successfully completed his PhD in 2009. His groundbreaking research during this period made significant contributions to the field of Bone Tissue Engineering by unraveling the biomaterial-driven molecular mechanisms governing the differentiation of human stem cells into osteoblasts. These pioneering findings were published in top-tier journals such as PNAS and Biomaterials. Continuing his academic journey, HF embarked on post-doctoral studies, where he established the use of high-throughput screening (HTS) technologies to identify and explore the role of small molecules in endothelial differentiation and function. In 2011, HF was invited to lead a new research group at the University of Twente, focusing on developing innovative translational technologies for tendon and ligament regeneration. During his tenure, HF provided mentorship to two Ph.D. students and one visiting Ph.D. student from Rutgers University (USA), as well as six MSc and six BSc students. The remarkable outcomes of their collaborative efforts resulted in the publication of seven peer-reviewed articles and the submission of a patent (P113734NL00). In 2014, HF joined the laboratory of Professor Lino Ferreira at the University of Coimbra (Portugal) where he directed his research towards two main areas: (i) the use of HTS platforms to discover miRNAs capable of modulating cell fate in the context of ageing & disease and (ii) engineering extracellular vesicles to deliver miRNAs in vivo. In 2020, HF received the prestigious “Individual Scientific Employment Stimuli” grant from the Portuguese Foundation of Science and Technology to further develop his research in the field of Molecular Bioengineering. In 2023, HF took up a position at the Multidisciplinary Institute of Ageing at the University of Coimbra, assuming the role of Principal Investigator and establishing his independent laboratory. His current research interests encompass (i) unravelling the mechanisms governing stem cell aging and (ii) developing therapeutic strategies capable of ameliorating or reversing this process. HF secured research funds exceeding €1.8M, and published 47 peer-reviewed manuscripts in journals such as PNAS, Biomaterials, and Molecular Therapy, accumulating over 2200 citations and achieving an h-index of 21 (Scopus). Additionally, HF has submitted two patents. HF is actively involved as a referee for several leading journals in the field of Bioengineering and as an Expert Evaluator for institutions such as the EU (Sklodowska-Curie fellowships; 2017-22), the French National Research Agency, the Dunhill Medical Trust, the Swiss National Science Foundation, Action Medical Research, and the Polish Science Foundation. HF's dedication to advancing the field is evident through his active participation as a Board Member (Secretary) of the Portuguese Society for Stem Cells and Cell Therapy since 2019. Since 2023, HF is elected member of the III-UC Scientific Council and MIA-UC.

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Identification

Personal identification

Full name: Hugo Agostinho Machado Fernandes
Date of birth: 1977/10/16
Gender: Male

Citation names

Fernandes, Hugo
Hugo Machado Fernandes
Fernandes, H.A.M.

Author identifiers

Ciência ID: CE15-5259-CC1D
ORCID iD: 0000-0002-4574-7648
Google Scholar ID: https://scholar.google.pt/citations?user=fzRUwicAAAAJ&hl=en
Researcher Id: H-6192-2014
Scopus Author Id: 32667641200

Email addresses

hugo.fernandes@uc.pt (Professional)
h.fernandes@me.com (Personal)

Telephones

Telephone

231249170 (Professional)

Addresses

UC-Biotech, Biocant Parque; Nucleo 4, Lote 8, 3060-197, Cantanhede, Cantanhede, Portugal (Professional)

Websites

https://advancedtherapies.cibb.uc.pt (Professional)
https://www.cnc.uc.pt/en/research-group/act-advanced-cell-technology (Professional)

Knowledge fields

Engineering and Technology - Other Engineering and Technologies
Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Advanced (C1)	Proficiency (C2)	Advanced (C1)
Spanish; Castilian	Upper intermediate (B2)	Advanced (C1)	Elementary (A2)	Advanced (C1)	Elementary (A2)

Education

	Degree	Classification
2013 Concluded	Designing a lesson and a course (Outros) Universiteit Twente, Netherlands
2013 Concluded	University Teaching Qualification (Pós-Graduação) Universiteit Twente, Netherlands
2013 Concluded	Guidelines and legislation for clinical trials in human subjects (Outros) Universiteit Twente, Netherlands
2012 Concluded	Time Management course (Outros) Universiteit Twente, Netherlands
2012 Concluded	Testing and assessment (Outros) Universiteit Twente, Netherlands
2012 Concluded	Supervising final projects (Outros) Universiteit Twente, Netherlands
2012 Concluded	Policy of Education and course coordination (Outros) Universiteit Twente, Netherlands
2011 Concluded	Certification program for Ingenuity Pathway Analysis (Outros) QIAGEN Bioinformatics, United States
2010 - 2010 Concluded	Dutch course – Follow-up III (Outros) Universiteit Twente, Netherlands
2010 Concluded	Analysis of microarray gene expression data (Outros) Universiteit Leiden, Netherlands
2009 Concluded	Biomedical Engineering (Doutoramento) Universiteit Twente, Netherlands "Instructive Elements for Bone Tissue Engineering" (THESIS/DISSERTATION)	N/A
2009 Concluded	Intensive week Dutch Course (Outros) Universiteit Twente, Netherlands
2009 Concluded	Dutch course – Follow-up I (Outros) Universiteit Twente, Netherlands
2009 Concluded	Dutch course – Follow-up II (Outros) Universiteit Twente, Netherlands
2007 Concluded	Presentation Skills course (Outros) Universiteit Twente, Netherlands
2007 Concluded	Technical writing and Editing training program (Outros) Universiteit Twente, Netherlands
2005 Concluded	Laboratory Animal Science (Outros) Universiteit Utrecht, Netherlands
2004 Concluded	Safety and Occupational Health (Pós-Graduação) Worfocus, Portugal
2002/03 - 2002/08 Concluded	Erasmus Exchange Student (Outros) Universidad Complutense de Madrid Facultad de Medicina, Spain	19/20
2002 Concluded	Applied Biology (Licenciatura) Universidade do Minho, Portugal "Immunopathologies of T lymphocytes" (THESIS/DISSERTATION)	14/20
1998 Attended	Systems Engineering and Computer Science (Licenciatura) Universidade do Minho Escola de Engenharia, Portugal "N/A" (THESIS/DISSERTATION)	N/A
1995/07/11 Concluded	Natural Sciences (Ensino secundário) Colégio Dom Diogo de Sousa, Portugal "N/A" (THESIS/DISSERTATION)	N/A

Affiliation

Science

	Category Host institution	Employer
2023/04 - Current	Principal Investigator (Research)	Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
	Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2018/11/17 - 2021/11	Invited Principal Investigator (Research)	University Coimbra - Faculty Medicine, Portugal

2017/11/17 - 2018/11/16	Invited Auxiliary Researcher (Research)	University Coimbra - Faculty Medicine, Portugal

2014/01/01 - 2017/11/16	Auxiliary Researcher (Research)	CNC.IBILI, Portugal

2011/09/01 - 2013/12/31	Auxiliary Researcher (Research)	Universiteit Twente, Netherlands

2004/01/01 - 2004/09/01	Researcher (Research)	Universidade do Minho, Portugal

Others

	Category Host institution	Employer
2024/01/02 - Current	Vice-President Portuguese Society of Stem Cells and Cell Therapies	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2023/05 - Current	Member of the Scientific Council of III-UC	Universidade de Coimbra, Portugal
	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/01 - Current	Member of Scientific Council MIA-Portugal	Universidade de Coimbra, Portugal
	Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2020/11/16 - 2023/04	Auxiliary Investigator - Scientific Employment Stimulus Award (FCT)	University Coimbra - Faculty Medicine, Portugal

2017/10 - 2019/10	National Coordinator - Science and Technology of Stem cells	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2009/02/01 - 2011/08/01	Postdoctoral Fellow	Universiteit Twente, Netherlands

2002/03/01 - 2002/08/01	Erasmus Exchange Student	Universidad Complutense de Madrid Facultad de Medicina, Spain

Projects

Grant

	Designation	Funders
2023/03 - Current	miRNA-engineered EVs for the treatment of diabetic wounds NA Principal investigator	Sociedade Portuguesa de Diabetologia
2015/07/01 - Current	Role of microRNAs in chondrogenesis of human mesenchymal stromal cells TAS Breakthrough #116005004 Integration into Research Grant Fellow Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Netherlands	Concluded
2022/07/01 - 2023/06/30	BIO-MED: Biomolecular Engineering of extracellular vesicles for Regenerative Medicine AAC nº01/SAICT/2021 - Project #181228 Co-Principal Investigator (Co-PI)	Programa Operacional Regional do Centro Ongoing
2021/11 - 2023/04	EV-Heart: cardioprotection and regeneration mediated by systemic administration of targeted miRNA-modulated extracellular vesicles CEECIND/01880/2018 Researcher Universidade de Coimbra Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluded
2018/08 - 2021/08	Exo-Heart: cardiac protection and regeneration mediated by systemic administration of targeted exosomes 029919	Fundação para a Ciência e a Tecnologia Concluded
2017/06/01 - 2021/06/01	Towards personalized beta-cell mass imaging in type 2 Diabetes 95105008 Integration into Research Grant Fellow ZonMw, Netherlands	ZonMw
2013/07 - 2015/06	Combinatorial approaches to promote cell survival - PROSURVIVAL 125994 Provided by PTCRIS: 125994	Fundação para a Ciência e a Tecnologia, I.P.

Contract

	Designation	Funders
2012/02/01 - 2016/02/01	Validation of bone marrow aspirate concentrator for reconstructive medicine NA Principal investigator Smith & Nephew, United States
2012/02/01 - 2016/02/01	Advanced Tendon and Ligament Healing NA Principal investigator Smith & Nephew, United States

Outputs

Publications

Book chapter	Thakkar, Shraddha; Fernandes, Hugo; Moroni, Lorenzo. "Decellularized Extracellular Matrix Scaffolds for Cartilage Regeneration". In Cartilage Tissue Engineering, 133-151. Springer New York, 2015. 10.1007/978-1-4939-2938-2_9 Fernandes, Hugo; Roderick Beijersbergen; Lino Ferreira; Koen Dechering; Prabhas Moghe; Katharina Maniura-Weber. "Bioassay Development". In Materiomics: high-Throughput Screening of Biomaterial Properties. Cambridge University Press, 2013. Fernandes, Hugo; Frits Hulshof; Er Liu; Andrea Negro; Samy Gobaa; Matthias Lutolf; Prabhas Moghe. "High-content Imaging". In Materiomics: high-Throughput Screening of Biomaterial Properties. Cambridge University Press, 2013.
Conference poster	Pinhanços, SS or Pinhanços, SM; Fernandes, Hugo. "Identification of microRNAs able to protect beta-cells from glucolipotoxicity using a High Throughput Screening approach". Paper presented in 3rd RESETageing Conference, 2023. Carlos Jesus; Fernandes, Hugo; Miguel LIno; Lino Ferreira. Corresponding author: Fernandes, Hugo. "Scalable production of Extracellular Vesicles from Mesenchymal Stem/Stromal Cells using a Hollow Fiber Bioreactor". Paper presented in ETRS-SPCETC Joint Annual Meeting 2023, 2023. Sandra Mimoso; Fernandes, Hugo. Corresponding author: Fernandes, Hugo. "Identification of miRNAs able to protect beta-cells from glucolipotoxicity using a high-throughput screening approach". Paper presented in ETRS-SPCETC Joint Annual Meeting 2023, 2023. Sandra Mimoso; Hugo Fernandes. Corresponding author: Hugo Fernandes. "Identification of miRNAs able to protect beta-cells from glucolipotoxicity using a high-throughput screening approach". Paper presented in EASD - European Association for the study of diabetes, 2023. Marta Barao; Fernandes, Hugo. "Extracellular vehicles enriched with an endothelial cell pro-survival microRNA impacts skin tissue regeneration". Paper presented in XXVII School of pure and applied biophysics - Extracellular Vesicles: from biophysical to translational challenges, 2023. Sandra Mimoso; João Teixeira; Martin Gotthard; Jorge Santos; Lino Ferreira; John Jones; Fernandes, Hugo. Corresponding author: Fernandes, Hugo. "High-throughput screening identifies microRNAs capable of rescuing beta cells from glucolipotoxicity-induced cell death.". Paper presented in International Diabetes Federation - World Congress, 2022. Sandra Mimoso; João Teixeira; Martin Gotthard; Jorge Santos; Lino Ferreira; John Jones; Fernandes, Hugo. Corresponding author: Fernandes, Hugo. "High-throughput screening identifies microRNAs capable of rescuing beta cells from glucolipotoxicity-induced cell death.". Paper presented in Early Career Network Winter School; European Association for the study of obesity, 2022. Fernandes, Hugo; Alessandra Zonnari; Ricardo Abreu; Sezin Aday; Marta Barão; Ines Albino; Miguel Lino; et al. "Extracellular vehicles enriched with an endothelial cell pro- survival microrna impacts skin tissue regeneration". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022. Fernandes, Hugo; Ricardo Abreu; Miguel Lino; Cristiana Ramos; Clarissa Becher; Carlos Jesus; Paula Martins; et al. "Biomolecular engineering of extracellular vesicles with micrornas". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022. Carlos Jesus. "Urinary extracellular vesicles as a tool for Regenerative Medicine.". Paper presented in 11th International Meeting of the Portuguese Society for stem cells and cell therapies, 2019. Abreu, Ricardo. "Bioengineered extracellular vesicles for Regenerative Medicine". Paper presented in Ageing: models, mechanisms and therapies, 2019. Abreu, Ricardo. "Extracellular Vesicle Engineering: modulation of non-coding RNA content". Paper presented in EMBO advanced course (Germany), 2018. Carlos Jesus. "Isolation and characterisation of urinary extracellular vesicles for Regenerative Medicine:". Paper presented in 1st Meeting on Vesicular Biology, 2018. Crispim, João F.. "Purification of platelet-rich plasma with peptide-functionalized microspheres". Paper presented in Orthopaedic Research Society Annual Meeting (USA), 2018. Lucienne Vonk. "microRNA-induced chondrogenic differentiation of mesenchymal stem cells". Paper presented in TERMIS-EU (Switzerland), 2017. Lucienne Vonk. "microRNA-induced chondrogenic differentiation of mesenchymal stroll cells". Paper presented in Orthopaedic Research Society Annual Meeting (USA), 2017. Crispim, João F.. "Use of synthetic peptides for the immobilisation of growth factors in wound healing". Paper presented in 9th International Meeting of the Portuguese Society for stem cells and cell therapies, 2015. Ekwueme, Emmanuel C.. "Proliferative therapy-induced changes in the cellular response of human tenocytes". Paper presented in Biomedical Engineering Society (BMES) annual meeting (USA), 2015. Ghebes, Corina Adriana. "accelerating ACL repair by understanding cellular communication in soft tissue to bone healing". Paper presented in 9th International Meeting of the Portuguese Society for stem cells and cell therapies, 2015. Ekwueme, Emmanuel C.. "Single-walled carbon nanotubes modulate tendon biomechanics and tenocyte cellular response:". Paper presented in TERMIS World Congress (USA), 2014. Criscenti G. "Realization of a soft-MI electrospun scaffold for tissue engineering applications". Paper presented in TERMIS-EU meeting (Italy), 2014. Ghebes, Corina-Adriana. "Accelerating ACL repair by understanding cellular communication in soft tissue to bone healing". Paper presented in Orthopaedic Research Society Annual Meeting (USA), 2014. Othman, Ziryan. "A proteomics approach to understand the role of calcium phosphate ceramics in bone regeneration". Paper presented in Netherlands Society for Biomaterials and Tissue Engineering (NBTE) Annual Meeting, 2014. Ivan Moldero. "Engineering stem cell distribution on 3D scaffolds influences cell activity". Paper presented in TERMIS-EU meeting (Italy), 2014. Vazão Helena. "Assessment of embryonic vascular toxicity by pluripotent stem cell-derived arterial endothelial cells on a microfluidic system". Paper presented in European Conference on Biomaterials,, 2013. Ghebes, Corina Adriana. "Hamstring tendon-derived cells, a cell source for anterior cruciate ligament reconstruction". Paper presented in Advances in Tissue Regeneration, November 2013 (Netherlands), 2013. Fernandes, Hugo. "Cell sources for anterior cruciate ligament reconstruction". Paper presented in 3th TERMIS World Congress (Austria), 2012. Fernandes, Hugo. "hypoxia mimicking small molecules induce an angiogenic trophic profile in human mesenchymal stromal cells". Paper presented in 3th TERMIS World Congress (Austria), 2012. Fernandes, Hugo. "hypoxia mimicking small molecules induce an angiogenic trophic profile in human mesenchymal stromal cells". Paper presented in Cell Symposia: Angiogenesis, metabolic regulation and cancer biology, Belgium., 2012. Le, Bach Q.. "High-throughput screening assay for the identification of compounds enhancing collagenous extracellular matrix production by ATDC5 cells". Paper presented in 21th conference of the Netherlands Society for Biomaterials and Tissue Engineering (Netherlands), 2012. Fernandes, Hugo. "human mesenchymal stromal cells as pro-angiogenic drug release systems". Paper presented in 4th International Angiogenesis Meeting, The Netherlands., 2011. Spitters, Tim W.G.M.. "The importance of gradients in articular cartilage". Paper presented in TERMIS-EU (Spain), 2011. Spitters, Tim W.G.M.. "Mimicking the knee joint, validation of a joint simulator". Paper presented in BMM/TerM Annual Meeting (Netherlands), 2011. Doorn, Joyce. "Hypoxia mimics as a tool to train human mesenchymal stroll cells for cell therapy applications". Paper presented in International Society for Cell Therapy (Netherlands), 2011. Portalska, Karolina Janeczek. "Mesenchymal stromal cells as a cell source in peripheral vascular disease treatment". Paper presented in STW Annual Congress (Netherlands), 2010. Barradas, Ana. "calcium phosphate ceramic particles accelerate osteogenesis of bone marrow cells". Paper presented in TERM SmartMix meeting (Netherlands), 2010. Portalska, Karolina Janeczek. "mesenchymal stem cells as potential sourcee for endothelial progenitors". Paper presented in Netherlands Society for Biomaterials and Tissue Engineering (NBTE) Annual Meeting, 2009. Fernandes, Hugo. "Investigating the role of collagen in osteogenic differentiation of human mesenchymal stem cells". Paper presented in TERMIS EU Meeting, Portugal, 2008. Fernandes, Hugo. "Investigating the role of the extracellular matrix on differentiation of human mesenchymal stem cells and MC3T3 cells". Paper presented in International bone and mineral research society workshop, Switzerland., 2008. Fernandes, Hugo. "Investigating the role of extracellular matrix on differentiation of human mesenchymal stem cells and MC3T3 cells". Paper presented in 17th conference of the Netherlands Society for Biomaterials and Tissue Engineering, The Netherlands., 2008. Sandra Teixeira. "in vitro and in vivo response of human mesenchymal stem cells to macroporous and interconnected ceramic scaffolds for bone tissue engineering". Paper presented in 8th World Biomaterials Congress (Netherlands), 2008. Sanne Both. "Bone tissue engineering in a rat cranial size defect with embryonic stem cells:". Paper presented in TERMIS-EU (United Kingdom), 2007. Prins HJ. "Bioluminescent imagineg (BLI) for in vivo tracing of human mesenchymal stem cell-based bone tissue engineering". Paper presented in TERMIS-EU (Netherlands), 2006. Prins HJ. "Bioluminescent imaging (BLI) for in vivo tracing of human mesenchymal stem cell-based bone tissue engineering". Paper presented in Netherlands Society for Biomaterials and Tissue Engineering Annual Meeting (Netherlands), 2006.
Journal article	Preto, António J.; Caniceiro, Ana B.; Duarte, Francisco; Fernandes, Hugo; Ferreira, Lino; Mourão, Joana; Moreira, Irina S.. "POSEIDON: Peptidic Objects SEquence-based Interaction with cellular DOmaiNs: a new database and predictor". Journal of Cheminformatics 16 1 (2024): http://dx.doi.org/10.1186/s13321-024-00810-7. 10.1186/s13321-024-00810-7 Ramos Rego, Inês; Silvério, Daniela; Eufrásio, Maria Isabel; Pinhanços, Sandra Sofia; Lopes da Costa, Bruna; Teixeira, José; Fernandes, Hugo; et al. "TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status". Antioxidants 12 2 (2023): 381. http://dx.doi.org/10.3390/antiox12020381. 10.3390/antiox12020381 Vilaça, Andreia; de Windt, Leon J.; Fernandes, Hugo; Ferreira, Lino. "Strategies and challenges for non-viral delivery of non-coding RNAs to the heart". Trends in Molecular Medicine (2022): http://dx.doi.org/10.1016/j.molmed.2022.10.002. In press • 10.1016/j.molmed.2022.10.002 Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; et al. Corresponding author: Fernandes, Hugo. "Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration". Molecular Therapy - Nucleic Acids 28 (2022): 307-327. http://dx.doi.org/10.1016/j.omtn.2022.03.018. 10.1016/j.omtn.2022.03.018 Esteves, Marta; Abreu, Ricardo; Fernandes, Hugo; Serra-Almeida, Catarina; Martins, Patrícia A.T.; Barão, Marta; Cristóvão, Ana Clara; et al. "MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease". Molecular Therapy (2022): http://dx.doi.org/10.1016/j.ymthe.2022.06.003. 10.1016/j.ymthe.2022.06.003 Ottaviani, L.; Juni, R.P.; de Abreu, R.C.; Sansonetti, M.; Sampaio-Pinto, V.; Halkein, J.; Hegenbarth, J.C.; et al. "Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells". Molecular Therapy (2022): http://dx.doi.org/10.1016/j.ymthe.2022.03.002. 10.1016/j.ymthe.2022.03.002 Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira. "High-throughput screening of nanoparticles in drug delivery". APL Bioengineering (2021): https://doi.org/10.1063/5.0057204. 10.1063/5.0057204 Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al. Corresponding author: Fernandes, Hugo. "Exogenous loading of miRNAs into small extracellular vesicles". Journal of Extracellular Vesicles 10 10 (2021): http://dx.doi.org/10.1002/jev2.12111. Open access • 10.1002/jev2.12111 Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino. Corresponding author: Ferreira, Lino. "A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies". Methods (2020): http://dx.doi.org/10.1016/j.ymeth.2020.12.002. 10.1016/j.ymeth.2020.12.002 de Abreu, Ricardo Cerqueira; Fernandes, Hugo; da Costa Martins, Paula A.; Sahoo, Susmita; Emanueli, Costanza; Ferreira, Lino. "Native and bioengineered extracellular vesicles for cardiovascular therapeutics". Nature Reviews Cardiology 17 11 (2020): 685-697. http://dx.doi.org/10.1038/s41569-020-0389-5. 10.1038/s41569-020-0389-5 Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al. "A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin". Cancers 12 2 (2020): 495. http://dx.doi.org/10.3390/cancers12020495. 10.3390/cancers12020495 Rosa, Susana; Pitrez, Patrícia; Fernandes, Hugo; Ferreira, Lino. Corresponding author: Fernandes, Hugo. "A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity". Current Protocols in Stem Cell Biology 50 1 (2019): http://dx.doi.org/10.1002/cpsc.93. 10.1002/cpsc.93 Othman, Ziryan; Fernandes, Hugo; Groot, Arjan J.; Luider, Theo M.; Alcinesio, Alessandro; Pereira, Daniel de Melo; Guttenplan, Alexander P.M.; Yuan, Huipin; Habibovic, Pamela. "The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics". Biomaterials 210 (2019): 12-24. http://dx.doi.org/10.1016/j.biomaterials.2019.04.021. 10.1016/j.biomaterials.2019.04.021 Honglin Chen; Danielle F. Baptista; Giuseppe Criscenti; João Crispim; Hugo Fernandes; Clemens van Blitterswijk; Roman Truckenmüller; Lorenzo Moroni. "From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation". Nanoscale 11 30 (2019): 14312-14321. https://doi.org/10.1039/C8NR10108F. 10.1039/C8NR10108F Criscenti G; De Maria C; Longoni A; van Blitterswijk CA; Fernandes HAM; Vozzi G; Moroni L. "Soft-molecular imprinted electrospun scaffolds to mimic specific biological tissues.". Biofabrication (2018): http://europepmc.org/abstract/med/30024388. 10.1088/1758-5090/aad48a Crispim JF; Fu SC; Lee YW; Fernandes HAM; Jonkheijm P; Yung PSH; Saris DBF. "Bioactive Tape With BMP-2 Binding Peptides Captures Endogenous Growth Factors and Accelerates Healing After Anterior Cruciate Ligament Reconstruction.". The American journal of sports medicine (2018): http://europepmc.org/abstract/med/30074814. 10.1177/0363546518787507 Ghebes, Corina Adriana; Groen, Nathalie; Cheuk, Yau Chuk; Fu, Sai Chuen; Fernandes, Hugo Machado; Saris, Daniel B.F.. Corresponding author: Fernandes, Hugo Machado. "Muscle-Secreted Factors Improve Anterior Cruciate Ligament Graft Healing: An In Vitro and In Vivo Analysis". Tissue Engineering Part A 24 3-4 (2018): 322-334. http://dx.doi.org/10.1089/ten.tea.2016.0546. 10.1089/ten.tea.2016.0546 Ekwueme, Emmanuel C.; Mohiuddin, Mahir; Yarborough, Jazmin A.; Brolinson, P. Gunnar; Docheva, Denitsa; Fernandes, Hugo A. M.; Freeman, Joseph W.. "Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro". Clinical Orthopaedics and Related Research® 475 8 (2017): 2117-2127. http://dx.doi.org/10.1007/s11999-017-5370-1. 10.1007/s11999-017-5370-1 Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al. "High-throughput identification of small molecules that affect human embryonic vascular development.". (2017): http://europepmc.org/abstract/med/28348206. 10.1073/pnas.1617451114 Crispim, J.; Fernandes, H.A.M.; Fu, S.C.; Lee, Y.W.; Jonkheijm, P.; Saris, D.B.F.. "TGF-ß1 activation in human hamstring cells through growth factor binding peptides on polycaprolactone surfaces". Acta Biomaterialia 53 (2017): 165-178. http://dx.doi.org/10.1016/j.actbio.2017.01.066. 10.1016/j.actbio.2017.01.066 Romão, Joana; Barata, David; Ribeiro, Nelson; Habibovic, Pamela; Fernandes, Hugo; Mul, Guido. Corresponding author: Fernandes, Hugo. "High throughput screening of photocatalytic conversion of pharmaceutical contaminants in water". Environmental Pollution 220 (2017): 1199-1207. http://dx.doi.org/10.1016/j.envpol.2016.11.015. 10.1016/j.envpol.2016.11.015 Ghebes CA; Braham MV; Zeegers AV; Renard AJ; Fernandes H; Saris DB. Corresponding author: Fernandes H. "Means of enhancing bone fracture healing: optimal cell source, isolation methods and acoustic stimulation.". (2016): http://europepmc.org/abstract/med/27955656. Ghebes, Corina-Adriana; van Lente, Jéré; Post, Janine Nicole; Saris, Daniel B. F.; Fernandes, Hugo. Corresponding author: Fernandes, Hugo. "High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-ß1 Signaling Pathway". SLAS DISCOVERY: Advancing Life Sciences R&D 22 1 (2016): 40-50. http://dx.doi.org/10.1177/1087057116669346. 10.1177/1087057116669346 Ekwueme, Emmanuel C.; Shah, Jay V.; Mohiuddin, Mahir; Ghebes, Corina A.; Crispim, João F.; Saris, Daniël B.F.; Fernandes, Hugo A.M.; Freeman, Joseph W.. "Cross-Talk Between Human Tenocytes and Bone Marrow Stromal Cells Potentiates Extracellular Matrix Remodeling In Vitro". Journal of Cellular Biochemistry 117 3 (2015): 684-693. http://dx.doi.org/10.1002/jcb.25353. 10.1002/jcb.25353 Higuera, Gustavo A.; Fernandes, Hugo; Spitters, Tim W.G.M.; van de Peppel, Jeroen; Aufferman, Nils; Truckenmueller, Roman; Escalante, Maryana; et al. "Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo". Biomaterials 61 (2015): 190-202. http://dx.doi.org/10.1016/j.biomaterials.2015.05.017. 10.1016/j.biomaterials.2015.05.017 Ghebes, Corina Adriana; Kelder, Cindy; Schot, Thomas; Renard, Auke J.; Pakvis, Dean F. M.; Fernandes, Hugo; Saris, Daniel B.. "Anterior cruciate ligament- and hamstring tendon-derived cells: in vitro differential properties of cells involved in ACL reconstruction". Journal of Tissue Engineering and Regenerative Medicine 11 4 (2015): 1077-1088. http://dx.doi.org/10.1002/term.2009. 10.1002/term.2009 Le B; Fernandes H; Bouten C; Karperien M; van Blitterswijk C; de Boer J. "High throughput screening assay for the identification of compounds enhancing collagenous extracellular matrix production by ATDC5 cells.". (2015): http://europepmc.org/abstract/med/25604243. 10.1089/ten.TEC.2014.0088 Thakkar, Shraddha; Ghebes, Corina A.; Ahmed, Maqsood; Kelder, Cindy; van Blitterswijk, Clemens A.; Saris, Daniel; Fernandes, Hugo A. M.; Moroni, Lorenzo. "Mesenchymal stromal cell-derived extracellular matrix influences gene expression of chondrocytes". Biofabrication 5 2 (2013): 10.1088/1758-5082/5/2/025003 Barradas, Ana M. C.; Monticone, Veronica; Hulsman, Marc; Danoux, Charlene; Fernandes, Hugo; Birgani, Zeinab Tahmasebi; Barrere-de Groot, Florence; et al. "Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells". Integrative Biology 5 7 (2013): 920-931. 10.1039/c3ib40027a Doorn, Joyce; Fernandes, Hugo A. M.; Le, Bach Q.; van de Peppel, Jeroen; van Leeuwen, Johannes P. T. M.; De Vries, Margreet R.; Aref, Zeen; et al. "A small molecule approach to engineering vascularized tissue". Biomaterials 34 12 (2013): 3053-3063. 10.1016/j.biomaterials.2012.12.037 Prins HJ; Fernandes H; Rozemuller H; van Blitterswijk C; de Boer J; Martens AC. "Spatial distribution and survival of human and goat mesenchymal stromal cells on hydroxyapatite and ß-tricalcium phosphate.". (2012): http://europepmc.org/abstract/med/23255230. 10.1002/term.1681 Barradas, Ana M.C.; Yuan, Huipin; van der Stok, Johan; Le Quang, Bach; Fernandes, Hugo; Chaterjea, Anindita; Hogenes, Marieke C.H.; et al. "The influence of genetic factors on the osteoinductive potential of calcium phosphate ceramics in mice". Biomaterials 33 23 (2012): 5696-5705. http://dx.doi.org/10.1016/j.biomaterials.2012.04.021. 10.1016/j.biomaterials.2012.04.021 Barradas, Ana M.C.; Fernandes, Hugo A.M.; Groen, Nathalie; Chai, Yoke Chin; Schrooten, Jan; van de Peppel, Jeroen; van Leeuwen, Johannes P.T.M.; van Blitterswijk, Clemens A.; de Boer, Jan. "A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells". Biomaterials 33 11 (2012): 3205-3215. http://dx.doi.org/10.1016/j.biomaterials.2012.01.020. 10.1016/j.biomaterials.2012.01.020 Portalska, Karolina Janeczek; Leferink, Anne; Groen, Nathalie; Fernandes, Hugo; Moroni, Lorenzo; van Blitterswijk, Clemens; de Boer, Jan. "Endothelial Differentiation of Mesenchymal Stromal Cells". Plos One 7 10 (2012): 10.1371/journal.pone.0046842 Yuan, Huipin; Fernandes, Hugo; Habibovic, Pamela; de Boer, Jan; Barradas, Ana M. C.; de Ruiter, Ad; Walsh, William R.; van Blitterswijk, Clemens A.; de Bruijn, Joost D.. "'Smart' biomaterials and osteoinductivity". Nature Reviews Rheumatology 7 4 (2011): 1-1. 10.1038/nrrheum.2010.210-c1 Nandakumar, Anandkumar; Fernandes, Hugo; de Boer, Jan; Moroni, Lorenzo; Habibovic, Pamela; van Blitterswijk, Clemens A.. "Fabrication of Bioactive Composite Scaffolds by Electrospinning for Bone Regeneration". Macromolecular Bioscience 10 11 (2010): 1365-1373. http://dx.doi.org/10.1002/mabi.201000145. 10.1002/mabi.201000145 Fernandes, Hugo; Dechering, Koen; van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Mentink, Anouk; van Blitterswijk, Clemens; de Boer, Jan. "Effect of Chordin-Like 1 on MC3T3-E1 and Human Mesenchymal Stem Cells". Cells Tissues Organs 191 6 (2010): 443-452. 10.1159/000281825 Fernandes, Hugo; Mentink, Anouk; Bank, Ruud; Stoop, Reinout; van Blitterswijk, Clemens; de Boer, Jan. "Endogenous Collagen Influences Differentiation of Human Multipotent Mesenchymal Stromal Cells". Tissue Engineering Part a 16 5 (2010): 1693-1702. 10.1089/ten.tea.2009.0341 Liu, Jun; Barradas, Ana; Fernandes, Hugo; Janssen, Frank; Papenburg, Bernke; Stamatialis, Dimitrios; Martens, Anton; van Blitterswijk, Clemens; de Boer, Jan. "In Vitro and In Vivo Bioluminescent Imaging of Hypoxia in Tissue-Engineered Grafts". Tissue Engineering Part C-Methods 16 3 (2010): 479-485. 10.1089/ten.tec.2009.0278 Teixeira, S.; Fernandes, H.; Leusink, A.; van Blitterswijk, C.; Ferraz, M. P.; Monteiro, F. J.; de Boer, J.. "In vivo evaluation of highly macroporous ceramic scaffolds for bone tissue engineering". Journal of Biomedical Materials Research Part a 93A 2 (2010): 567-575. 10.1002/jbm.a.32532 Yuan, Huipin; Fernandes, Hugo; Habibovic, Pamela; de Boer, Jan; Barradas, Ana M. C.; de Ruiter, Ad; Walsh, William R.; van Blitterswijk, Clemens A.; de Bruijn, Joost D.. "Osteoinductive ceramics as a synthetic alternative to autologous bone grafting". Proceedings of the National Academy of Sciences of the United States of America 107 31 (2010): 13614-13619. 10.1073/pnas.1003600107 Fernandes, Hugo; Dechering, Koen; Van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Leusink, Anouk; Bank, Ruud; et al. "The Role of Collagen Crosslinking in Differentiation of Human Mesenchymal Stem Cells and MC3T3-E1 Cells". Tissue Engineering Part A 15 12 (2009): 3857-3867. http://dx.doi.org/10.1089/ten.tea.2009.0011. 10.1089/ten.tea.2009.0011 Siddappa, Ramakrishnaiah; Mulder, Winfried; Steeghs, Ilse; van de Klundert, Christine; Fernandes, Hugo; Liu, Jun; Arends, Roel; van Blitterswijk, Clemens; de Boer, Jan. "cAMP/PKA Signaling Inhibits Osteogenic Differentiation and Bone Formation in Rodent Models". Tissue Engineering Part A 15 8 (2009): 2135-2143. http://dx.doi.org/10.1089/ten.tea.2008.0512. 10.1089/ten.tea.2008.0512 Schop, Deborah; Janssen, Frank W.; van Rijn, Linda D.S.; Fernandes, Hugo; Bloem, Rolf M.; de Bruijn, Joost D.; van Dijkhuizen-Radersma, Riemke. "Growth, Metabolism, and Growth Inhibitors of Mesenchymal Stem Cells". Tissue Engineering Part A 15 8 (2009): 1877-1886. http://dx.doi.org/10.1089/ten.tea.2008.0345. 10.1089/ten.tea.2008.0345 Fernandes, Hugo; Moroni, Lorenzo; van Blitterswijk, Clemens; de Boer, Jan. "Extracellular matrix and tissue engineering applications". Journal of Materials Chemistry 19 31 (2009): 5474-5484. 10.1039/b822177d Siddappa, Ramakrishnaiah; Fernandes, Hugo; Liu, Jun; van Blitterswijk, Clemens; de Boer, Jan. "The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering.". Current stem cell research & therapy 2 3 (2007): 209-20. 10.2174/157488807781696267 Teixeira, S.; Fernandes, H.M.; De Boer, J.; Ferraz, M.P.; Monteiro, F.J.. "Mesenchymal stem cell proliferation and morphological analysis on interconnected macroporous structures". Key Engineering Materials 330-332 II (2007): 1129-1132. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846317063&partnerID=MN8TOARS.
Newsletter article	Susana Simões; Fernandes, Hugo; Lino da Silva Ferreira. "Recent advances on non viral CRISPR nano formulations for brain delivery and clinical approaches", ARRIGE (Association for responsible research and innovation in genome editing Newsletter), 2021, https://www.arrige.org/wp-content/uploads/2021/10/ARRIGE_newsletter_issue4.pdf.

Intellectual property

Patent	Fernandes, Hugo; Ferreira, L; Vazão, H. 2016. "Differentiated cell population of endothelial cells derived from human pluripotent stem cells, composition system, kit and uses therefore".
Provisional application for patent	2015. "Functionalization of biopolymers with growth factor-binding peptides".

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/04/27	Células estaminais: os mágicos dentro de nós!	Escola Ciência Viva UC Exploratório (Coimbra)
2023/09/29	Unlocking the regenerative potential of extracellular vesicles: bioactivity enhancement through miRNA modulation	Groningnen – Jena Aging Meeting (G-JAM) 2023 ERIBA, University Groningen (Groningen, Netherlands)
2023/08/03	Medicina Regenerativa e o envelhecimento: A jornada da vida - The lecture was delivered to students attending "Senior University" and other attendants of Expofacic 2023 (the biggest Fair in the Center Region of Portugal).	Expofacic 2023 Expofacic (Cantanhede, Portugal)
2023/03/24	Stem Cells - a lecture for Primary School students	Rómulo Centro de Ciência Viva (Coimbra)
2023/03/17	miRNAs que aumentam a sobrevivência e proliferação de células beta estão alterados em doentes diabéticos submetidos a cirurgia bariátrica (BEST ORAL PRESENTATION)	19º Congresso Português de Diabetes Portuguese Society Diabetology
2023/03	Stem Cells - definition and applications	Course Biotecnologia IEC Colégio Nossa Senhora Assunção (Anadia)
2023/02/08	Extracellular vesicles: biomarkers and Regenerative Medicine applications	Centro Hospitalar e Universitário Coimbra (Serviço Nefrologia)
2022/12/07	Engineering extracellular vesicles for Regenerative Medicine applications	Ageing Without Borders SPCE-TC and Universidade Algarve (Faro, Portugal)
2022/11	Engineering Extracellular Vesicles for Regenerative Medicine applications	CIBB Innovative Therapies Annual Meeting CIBB (Portugal)
2022/10/13	Células estaminais e seus derivados: a fonte da juventude mais perto de si! Online presentations to high school students explaining what are stem cells and their applications. The following schools participated in the event: Agrupamento de Escolas do Fundão (Fundão) and Escola Secundária Morgado de Mateus (Vila Real)	Dia Mundial células estaminais Ciência Viva (Portugal)
2022/09	REGENERAÇÃO DE TECIDOS E FONTE DA JUVENTUDE - NA FARMÁCIA MAIS PRÓXIMA!	Ciência às seis Rómulo - Centro Ciência Viva Universidade de Coimbra (Coimbra, Portugal)
2022/03/12	miRNAs e vesículas extracelulares: uma nova terapia no tratamento do síndrome metabólico,	18th Congresso Português de diabetes Sociedade Portuguesa Diabetes
2022	High-throughput screening identifies microRNAs capable of rescuing beta cells from glucolipotoxicity-induced cell death	Early Career Network Winter School European Association for the study of obesity (Spain)
2022	High-throughput screening identifies microRNAs capable of rescuing beta cells from glucolipotoxicity-induced cell death	International Diabetes Conference World Congress International Diabetes Foundation (Portugal)
2021/10/25	Science and Stem Cells. Seminars about science and stem cells organized at Centro Escolar Cantanhede. During one week (1h/day) I had the chance to present our work and discuss with the students science and cell biology	Science and Stem cells Centro Escolar Cantanhede (Cantanhede)
2021/10/13	Stem Cell Seminar	Celebrations Stem Cell Day 2021 Escola Secundária Infanta D. Maria (Coimbra)
2021/10/13	Stem Cell Seminar	Escola Básica da Ponte das Três Entradas (São Sebastião Feira)
2021/09/14	microRNA-modulated extracellular vesicles for Regenerative Medicine applications	1st Meeting Portuguese Society Extracellular Vesicles I3S (Portugal)
2021/09/06	miRNA-engineered extracellular vesicles for Regenerative Medicine applications	31st Conference European Society Biomaterials ESB (Porto, Portugal)
2021/06/10	miRNA-modified extracellular vesicles for wound regeneration	55th Anual Scientific Meeting European Society for Clinical Investigation
2021/06/10	Extracellular vesicles as lncRNA-H19 carriers to the cardiovascular system Presented by Andreia Vilaça	55th Anual Scientific Meeting European Society for Clinical Investigation
2020/12	Non-coding RNA-engineered extracellular vesicles for cardiac regeneration,	1st Workshop of the Portuguese Network on Extracellular Vesicles Portuguese Network on Extracellular Vesicles (Online, Portugal)
2020/11/06	Harnessing the power of extracellular vesicles for wound regeneration	11th International Congress on Skin Ageing & Challenges 2020 (Porto (Virtual Meeting), Portugal)
2019/11	Diálogos com cientistas - Colégio Nossa Senhora Assunção (Anadia)	Lecture with high-school students about stem cells and cardiovascular diseases
2019/10/11	High-content screening identifies pro-survival microRNas	11th International Meeting of the Portuguese Society for stem cells and cell therapies Faculty Pharmacy Lisbon (Portugal)
2019/05	Human cardiac stem cell therapy	PhD Program in Health Sciences Faculty Medicine, University Coimbra
2019/04/13	Tailoring Biomaterials for Tissue Engineering	Seminar Master Course in Pharmaceutical Biotechnology Faculty of Pharmacy, University Coimbra (Portugal)
2019/04	“Regenerative Medicine: from the bench to the bedside and stem cells and drug screening”	Course on Advanced Therapies, PhD Program in Experimental Biology and Biomedicine Center Neuroscience and Cell Biology (Portugal)
2019/04	Tailoring Biomaterials for Tissue Engineering”	Master in Pharmaceutical Biotechnology Faculty of Pharmacy, University Coimbra (Portugal)
2018	High-content screening identifies pro-survival microRNAs	29th Annual Meeting of the European Society of Biomaterials European Society Biomaterials (Netherlands)
2018	Smart technologies to enable tissue regeneration	IV National Meeting Biotechnology Instituto Politécnico Coimbra (Portugal)
2018	CardioSTem Project	MIT Portugal Annual Conference (Portugal)
2018	Identification of pro survival microRNAs	Curso de “CIÊNCIAS CARDIOVASCULARES” Programa de Doutoramento em Ciências da Saúde, da Faculdade de Medicina da Universidade de Coimbra CNC.IBILI (Portugal)
2018	Stem Cells and Regenerative Medicine	Invited University Aveiro (Portugal)
2017	High-throughput screening identifies pro-survival microRNas	10th International Meeting of the Portuguese Society for stem cells and cell therapies (Portugal)
2017	From a medical problem to a product: new avenues in the treatment of skeletal disorders	III Ciclo de Conferências em Biotecnologia Medicinal e Farmacêutica Universidade Beira Interior (Portugal)
2017	Cell therapies for cardiac repair: role of microRNAs on cell survival	Stem Cell Symposium Portuguese Society for stem cells and cell therapies (Portugal)
2017	Identification of microRNAs capable of enhancing cell survival:	Heart Without Borders (Portugal)
2017	Identification of microRNAs capable of enhancing cell survival	Curso de “CIÊNCIAS CARDIOVASCULARES” Programa de Doutoramento em Ciências da Saúde, da Faculdade de Medicina da Universidade de Coimbra CNC.IBILI (Portugal)
2017	Stem cells and drug screening	MIT-Portugal, PhD Program Lectures Instituto Superior Técnico - Universidade Lisboa (Portugal)
2017	Identification of microRNAs capable of enhancing cell survival	Department of Physiology and cardiothoracic surgery, Faculty Medicine, University Porto University Porto (Portugal)
2017	Capturing endogenous growth factors through synthetic peptides to enhance healing of tendons and ligaments	Orthopaedic Research Society Orthopaedic Research Society (United States)
2016	Cell therapies for cardiac repair: role of microRNAs on cell survival	Curso de “CIÊNCIAS CARDIOVASCULARES” Programa de Doutoramento em Ciências da Saúde, da Faculdade de Medicina da Universidade de Coimbra CNC.IBILI (Portugal)
2016	High-content screening identifica pro-survival microRNAs	Institutional Seminars CNC CNC.IBILI (Portugal)
2016	Identification of pro-survival microRNAs to improve cell survival	Centro Hospitalar Universidade Coimbra (Portugal)
2016	Stem cells and Drug Screening	MIT-Portugal; PhD Program Lecturer Instituto Superior Técnico, Universidade Lisboa (Portugal)
2015	a small molecule approach to engineering vascularised tissue	th International Meeting of the Portuguese Society for stem cells and cell therapies Portuguese Society for stem cells and cell therapies (Portugal)
2015	Stem cells and cell-material interactions	Lecture Master Degree Biomedical Engineering University Aveiro (Portugal)
2015	Stem cells and drug screening	MIT-Portugal; PhD Program Lecture Instituto Superior Técnico, Universidade de Lisboa (Portugal)
2015	Bioengineering strategies to modulate stem cell fate	Institutional Seminar CNC.IBILI (Portugal)
2015	Stem Cells and Clinical Applications: are we doing it right?	UC-Biotech Seminars CNC.IBILI (Portugal)
2015	ways to enhance musculoskeletal repair	MIRA Biomedical technology and technical medicine day University Twente (Netherlands)
2014	Use of synthetic peptides for the delivery of growth factors for tendon/ligament healing	TERMIS World Congress (USA) TERMIS (United States)
2014	Engineering stem cell distribution on 3D scaffolds influences cell activity	TERMIS-EU meeting TERMIS (Italy)
2014	Cross-talk between human tenocytes and bone marrow stroll cells potentiates extracellular matrix remodelling in vitro:	TERMIS World Congress (USA) TERMIS (United States)
2014	Bio-instructive approach to accelerate ligament/tendon healing:	Netherlands Society for Biomaterials and Tissue Engineering (NBTE) Annual Meeting Netherlands Society for Biomaterials and Tissue Engineering (Netherlands)
2014	Assessment of embryonic vascular toxicity by pluripotent stem cell-derived arterial endothelial cells on a microfluidic system	TERMIS-EU meeting TERMIS (Italy)
2013	Enabling technologies to control cell fate	Invited Seminar Ferreira Lab (Portugal)
2013	Tenogenic response of bone marrow stromal cells and tenocyte co-cultures	Netherlands Society for Biomaterials and Tissue Engineering Annual Meeting (NBTE) Netherlands Society for Biomaterials and Tissue Engineering (Netherlands)
2013	characterisation of hamstring tendon-derived cells and their crosstalk with neighbouring cell types involved in embryonic development of tendons	Netherlands Society for Biomaterials and Tissue Engineering Annual Meeting (NBTE) Netherlands Society for Biomaterials and Tissue Engineering
2012	A novel player in angiogenesis	Invited Seminar Dankers Lab Technical University of Eindhoven (Netherlands)
2011	topographical library to control stem cell fate	3rd COST TD0903 meeting (Romania)
2011	human mesenchymal stromal cells as pro-angiogenic releasing systems	4th International Conference on Tissue Engineering (Greece)
2011	A novel player in angiogenesis	Invited Lecture Ferreira Lab (Portugal)
2011	Training mesenchymal stromal cells for tissue engineering applications	University Munich Seminars (Germany)
2009	Hidden talents of stem cells	World Congress on Regenerative Medicine (Germany)
2008	Role of collagen cross linking in osteogenic differentiation:	8th World Biomaterials Congress (Netherlands)
2007	potential application of extracellular matrix proteins to control osteogenic differentiation of human mesenchymal stem cells	16th conference of the Netherlands Society for Biomaterials and Tissue Engineering (Netherlands)
2007	potential application of extracellular matrix proteins to control osteogenic differentiation of human mesenchymal stem cells:	17th Annual meeting of the Dutch Society for Calcium and bone metabolism (Netherlands)
2006	Role of extracellular matrix on osteogenic differentiation	5th conference of the Netherlands Society for Biomaterials and Tissue Engineering (Netherlands)
2006	Role of extracellular matrix on osteogenic differentiation	16th Annual Meeting of the Dutch Society for Calcium and Bone metabolism (Netherlands)
2006	Bone tissue engineering in a rat cranial critical defect with embryonic stem cells	Dutch Society for Biomaterials and Tissue Engineering Dutch Society for Biomaterials and Tissue Engineering (Netherlands)
2003	Career options	5th Meeting of Applied Biology Universidade Minho (Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2022/08 - Current	miRNA-engineered extracellular vesicles to improve skin wound healing (MSC Andrea Carolina Larrea) Supervisor	Università degli Studi del Piemonte Orientale Amedeo Avogadro, Italy
2021/01 - Current	Engineering extracellular Vesicles to enhance wound healing (PhD Marta Barão) Co-supervisor
2020/03 - Current	Urinary extracellular vesicles as modulators of endothelial and beta-cell function in Type 2 diabetes (PhD Sandra Mimoso) Supervisor
2019/12 - Current	Cardioprotection and regeneration mediated by systemic administration of targeted extracellular vesicles (PhD Carlos Jesus) Co-supervisor
2018/09 - Current	Towards personalised beta-cell mass imaging in type 2 diabetes (Research Assistant Sandra Mimoso) Supervisor	CNC.IBILI, Portugal
2018/09 - Current	Urine extracellular vesicles: a promising tool for Regenerative Medicine (MSc Inês Morais) Supervisor	Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09 - 2022/10	Targeting the heart: Extracellular vesicles and beyond (PhD Andreia Vilaça) Co-supervisor	Universidade de Coimbra, Portugal Universiteit Maastricht, Netherlands
2022/02 - 2022/07	Modulation of Extracellular Vesicles for Regenerative Medicine (BSc Tomás Coimbra) Supervisor	Lic. Biochemistry (Degree) Universidade de Coimbra, Portugal
2018 - 2022/02/21	Extracellular Vesicles as Platforms for Therapeutic microRNA delivery (PhD Ricardo Abreu) Co-supervisor	Universiteit Maastricht, Netherlands Universidade de Coimbra, Portugal
2018/09 - 2019/09	Uncover the mechanism behind miRNA function on cell survival (MSc Marta Barão) Supervisor	Universidade de Coimbra Faculdade de Medicina, Portugal
2019 - 2019	High-Throughput screening for extracellular vesicle content modulation for cardiovascular application (MSc Clarissa Becher) Supervisor	Master Georg-August-Universität Göttingen Universitätsmedizin, Germany
2018/02 - 2018/09	Mechanism of action of pro-survival microRNAs (Research Assistant - Inês Albino) Supervisor	CNC.IBILI, Portugal
2018/01 - 2018/09	Towards personalised beta-cell mass imaging in type 2 diabetes (Research Assistant Ana Branco) Supervisor	CNC.IBILI, Portugal
2018 - 2018	Urine extracellular vesicles: waste or a powerful tool? (MSc Carlos Jesus) Supervisor	Universidade de Coimbra, Portugal
2014/04 - 2017/09	Improving hematopoietic stem cell expansion using small molecules (Postdoctoral Fellowship Ana Barradas) Supervisor	Postdoctoral Fellow, FCT Scholarship: SFRH/BPD/97286/2013 (Other) CNC.IBILI, Portugal
2017 - 2017	The role of miRNAs on cell survival (MSc Cátia Seabra) Supervisor	Universidade de Coimbra, Portugal
2013/07 - 2016/12	Functionalized surfaces for ligament tissue engineering (PhD João Crispim) Supervisor	Universiteit Twente, Netherlands
2012/03 - 2016/09	Means of accelerating tendon graft healing after ACL reconstruction (PhD Corina Ghebes) Supervisor	Universiteit Twente, Netherlands
2016 - 2016	Identification of microRNAs to promote cell survival for the treatment of ischemic diseases (MSc Carolina Santos) Supervisor	Universidade de Coimbra, Portugal
2015 - 2015	Optimizing an high-throughput screening assay for hematopoietic stem cell expansion in co-culture with Wharton´s Jelly mesenchymal stem cells (BSc Beatriz Martins) Supervisor	Universidade de Coimbra, Portugal
2013/09 - 2014/02	Non-surgical tissue engineering approaches to sub-failure ligament and tendon injury repair (PhD Emmanuel Ekwueme) Co-supervisor	Rutgers The State University of New Jersey, United States
2014 - 2014	Functionalized surfaces stimulating tendon/ligament healing by activation of the TGFb1 signalling (MSc Joyce Mulder) Supervisor	Universiteit Twente, Netherlands
2014 - 2014	High-throughput screening to identify BMP-2 mimicking drugs (BSc Stijn t´Groen) Supervisor	Universiteit Twente, Netherlands
2014 - 2014	Screening for small molecules that mimic TGF-b activation (BSc Jere van Lente) Supervisor	Universiteit Twente, Netherlands
2013 - 2014	Bioassay development to identify pro-survival and pro-angiogenic compounds (MSc Thijs Beuving) Supervisor	Universiteit Twente, Netherlands
2013 - 2014	New technologies for the isolation and priming of bone marrow cells (MSc Maaike Braham) Supervisor	Universiteit Twente, Netherlands
2013 - 2014	High-throughput screening for tendon and ligament healing (MSc Tânia Barata) Supervisor	Universiteit Twente, Netherlands Universidade de Trás-os-Montes e Alto Douro, Portugal
2013/09 - 2013/10	Tendon and Ligament Engineering (Postdoctoral Fellow Carlo Rossi) Supervisor	Postdoctoral Fellow (Other) Universiteit Twente, Netherlands
2013 - 2013	Crosstalk between mesenchymal stem cells and muscle, cartilage and bone cells in co-culture (BSc Robert Wisse) Supervisor	Universiteit Twente, Netherlands
2013 - 2013	Influence of cell shape on cell fate decision (BSc Mariana Silva) Supervisor	Universiteit Twente, Netherlands Universidade do Minho, Portugal
2013 - 2013	Characterization of hamstring and anterior cruciate ligament cells (BSc Thomas Schot) Supervisor	Universiteit Twente, Netherlands
2012 - 2012	The effect of cell shape on cell fate (MSc Hugo Moonen) Supervisor	Universiteit Twente, Netherlands
2012 - 2012	Characterization of anterior cruciate ligament derived cells (BSc Cindy Kelder) Supervisor	Universiteit Twente, Netherlands
2011 - 2011	The power of extracellular matrix (MSc Shraddha Thakkar) Co-supervisor	Universiteit Twente, Netherlands
2010 - 2010	Endothelial differentiation of mesenchymal stem cells (MSc Nathalie Groen) Co-supervisor	Universiteit Twente, Netherlands
2008 - 2008	Relation between hMSCs diffreentiation, cell shape and focal adhesion assembly (MSc Karolina Janeczek) Co-supervisor
2007 - 2007	The effect of extracellular matrix recombinant proteins on osteogenic differentiation of human mesenchymal stem cells (BSc Monique Slijp) Co-supervisor	Universiteit Twente, Netherlands

Event organisation

	Event name Type of event (Role)	Institution / Organization
2015 - Current	Organisation of the weekly Seminars at UC-Biotech (2015) Seminar (Member of the Organising Committee)	Universidade de Coimbra, Portugal
2001 - Current	Organisation of the 3rd Meeting of Applied Biology. Contributed to the outline of the meeting. (2001)
2023/10/10 - 2033/10/13	European Tissue Repair Society (ETRS) - Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC) joint annual meeting. This was the first joint meeting between the two Societies and it was an opportunity to exchange knowledge and ideas and to create new opportunities. We gathered ~200 people in Coimbra. (2023/10/10 - 2023/10/13) Conference (President of the Organising Committee)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal Universidade de Coimbra, Portugal
2021/10/13 - 2021/10/13	Organization of the Stem Cell Day - together with other scientists we organized seminars at different schools in the Center Region of Portugal. (2021/10/13 - 2021/10/13) Seminar (President of the Organising Committee)	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2021/09/17 - 2021/09/17	3rd Retreat of CIBB's Innovative Therapies Area. Annual meeting organized by CIBB thematic strand Innovative Therapies led by Lino Ferreira. The goal is to get together, share the latest scientific achievements, get to know new members and socialize in an informal manner. (2021/09/17) Meeting (Member of the Organising Committee)	Centre for Innovative Biomedicine and Biotechnology, Portugal
2021 - 2021	Symposium "Extracellular Vesicles for Tissue Regeneration". I proposed the symposium and invited the Keynote speaker, Professor Eduardo Marban, Director, Cedars-Sinai Heart Institute (USA). (2021) Symposium (President of the Organising Committee)	Tissue Engineering and Regenerative Medicine International Society, United States
2020/01/16 - 2020/01/16	Organisation of an in-site visit to high school students (Escola Secundária Moimenta da Beira). I delivered a lecture on stem cells and organised the visit to the different laboratories. (2020/01/16 - 2020/01/16)	CNC.IBILI, Portugal
2019/10/25 - 2019/10/25	Organisation of an in-site visit to high school students (Colégio Nossa Senhora Assunção, Anadia). I delivered a lecture about stem cells and organised the visit to the different laboratories. (2019/10/25)

Event participation

	Activity description Type of event	Event name Institution / Organization
2023/03 - Current	6º Meetup Digital Health Portugal: Biobanks Conference	6º Meetup Digital Health Portugal: Biobanks
2022/10/27 - Current	The Bioengineering - One Health Alliance in 2050: A One-Day voyage into the Future. Symposium with experts in Bioengineering to discuss the global challenges for 2050, particularly the ones requiring an interdisciplinary approach, involving social sciences, ethics, biology, medicine, and engineering. The aim was to break artificial boundaries between scientific domains, and adopting the concept of One Health, perceived as the holistic view on Health, in its components of Human Health, Animal Health and Environmental Health. Symposium	The Bioengineering - One Health Alliance in 2050: A One-Day voyage into the Future Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/01 - Current	Research in higher education: How and what for? A meeting organised by the General Council University of Coimbra to discuss Research in Higher Education. Meeting	Research in higher education: How and what for?
2021/06/11 - Current	The first meeting of the consortium RESETageing, an EU-financed Twinning project with the University of Groningen and University of Maastricht (The Netherlands), and University Newcastle (UK). Conference	1st RESETageing Conference Universidade de Coimbra, Portugal
2019/02/27 - Current	diálogos com cientistas - seminar about stem cells and cell therapy Seminar	Cardiovascular Diseases and cell therapy Escola Secundária Oliveira Bairro, Portugal
2019/02/22 - Current	Conferencias na Escola - Engagement with high school students. Seminar	Conferências na Escola Escola Secundária Marques Castilho, Portugal
2019 - Current	Outreaching activity for High-school students and professors. Seminar	Células estaminais e Medicina Regenerativa Instituto de Educação e Cidadania, Portugal
2018 - Current	1st Meeting on Vesicular Biology Meeting	1st Meeting on Vesicular Biology
2017 - Current	Diálogos de Verão com cientistas Round table	Doenças Cardiovasculares Instituto de Educação e Cidadania, Portugal
2016 - Current	Mês da Ciência Symposium	Células Estaminais e Terapias Celulares Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2016 - Current	Curso avançado de células estaminais Seminar	Curso avançado de células estaminais Instituto de Educação e Cidadania, Portugal
2016 - Current	1st Meeting on Biomedical Research Meeting	1st Meeting on Biomedical Research
2015 - Current	Curso avançado de células estaminais Seminar	Curso avançado de células estaminais Instituto de Educação e Cidadania, Portugal
2013 - Current	Advances in Tissue Regeneration Symposium	Advances in Tissue Regeneration, November 2013, The Netherlands.
2012 - Current	Poster Presentation: Cell sources for anterior cruciate ligament reconstruction Conference	TERMIS International, Austria. Universiteit Twente, Netherlands
2012 - Current	Poster Presentation: hypoxia mimicking small molecules induce an angiogenic trophic profile in human mesenchymal stromal cells. (Travel Award) Conference	TERMIS International, Austria.
2012 - Current	Poster Presentation: hypoxia mimicking small molecules induce an angiogenic trophic profile in human mesenchymal stromal cells Symposium	Cell Symposia: Angiogenesis, metabolic regulation and cancer biology, Belgium.
2011 - Current	Poster Presentation: human mesenchymal stromal cells as pro-angiogenic drug release systems Meeting	4th International Angiogenesis Meeting, The Netherlands. Universiteit Twente, Netherlands
2011 - Current	20th conference of the Netherlands Society for Biomaterials and Tissue Engineering Conference	20th conference of the Netherlands Society for Biomaterials and Tissue Engineering
2011 - Current	21st Annual Meeting of the Dutch Society for Calcium and Bone Metabolism Meeting	21st Annual Meeting of the Dutch Society for Calcium and Bone Metabolism
2011 - Current	High-Throughput screening – shaping a new research area Workshop	High-Throughput screening – shaping a new research area
2009 - Current	Gordon Research Conference in Vascular Cell Biology Conference	Gordon Research Conference in Vascular Cell Biology
2008 - Current	Poster Presentation: Investigating the role of collagen in osteogenic differentiation of human mesenchymal stem cells Meeting	TERMIS EU Meeting, Portugal. Universiteit Twente, Netherlands
2008 - Current	Poster Presentation: Investigating the role of the extracellular matrix on differentiation of human mesenchymal stem cells and MC3T3 cells Workshop	International bone and mineral research society workshop, Switzerland. Universiteit Twente, Netherlands
2008 - Current	Poster Presentation: Investigating the role of extracellular matrix on differentiation of human mesenchymal stem cells and MC3T3 cells Conference	17th conference of the Netherlands Society for Biomaterials and Tissue Engineering, The Netherlands. Universiteit Twente, Netherlands
2007 - Current	Dutch Program for Tissue Engineering meeting Meeting	Dutch Program for Tissue Engineering meeting
2007 - Current	1st Dutch Conference on Bio-Medical Engineering Conference	1st Dutch Conference on Bio-Medical Engineering
2005 - Current	15th Annual Meeting of the Dutch Society for Calcium and Bone Metabolism Meeting	15th Annual Meeting of the Dutch Society for Calcium and Bone Metabolism
2005 - Current	iBME Meeting Meeting	iBME Meeting
2005 - Current	Dutch Symposium on Tissue Engineering Symposium	Dutch Symposium on Tissue Engineering
2005 - Current	Embryonic Stem Cells symposium, Hubrecht Laboratory, April 2005, The Netherlands. Symposium	Embryonic Stem Cells symposium Hubrecht Institute, Netherlands
2005 - Current	International Workshop textbook Tissue Engineering Workshop	International Workshop textbook Tissue Engineering
2004 - Current	13th conference of the Netherlands Society for Biomaterials and Tissue Engineering Conference	13th conference of the Netherlands Society for Biomaterials and Tissue Engineering
2000 - Current	2nd Meeting of Applied Biology Meeting	2nd Meeting of Applied Biology, University of Minho Universidade do Minho, Portugal
1999 - Current	1st Meeting of Applied Biology Meeting	1st Meeting of Applied Biology Universidade do Minho, Portugal
2023/12/06 - 2023/12/07	Participation in the 3rd RESETAgeing Conference Conference	3rd RESETAgeing Conference
2023/06/10 - 2023/06/13	37th Annual Meeting of the International Society for Heart Research - European Section Session Chair and Poster Evaluator Conference	37th Annual Meeting of the International Society for Heart Research - European Section International Society for Heart Research, United States
2022/03/10 - 2022/03/11	12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies. Chair of the panel on Exosomes. Meeting	12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
2021/10/15 - 2021/10/15	Stem Cell Day 2021 - event organized by the Portuguese Society Stem Cells and Cell Therapy in collaboration with Ciência Viva Seminar	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal Ciência Viva, Portugal
2019/12/19 - 2019/12/20	CIBB Meeting 2019 - meeting organised by CIBB to foster collaboration between its members. Chair of the session on Advanced Therapies Meeting	CNC.IBILI, Portugal
2019/11 - 2019/11	Semana Ciência e da Tecnologia 2019 - lab tour to high-school students at UC-Biotech.	Science and Technology week 2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/01/30	STAPHYLOCOCCUS AUREUS INTRACELLULAR LIFESTYLE: PHENOTYPIC PROFILES AND UNDERLYING MOLECULAR DETERMINANTS President of the jury	Inês Rodrigues Lopes (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2024/01/22	CHARACTERIZATION OF PROTEIN- PROTEIN INTERACTIONS INVOLVING G PROTEIN-COUPLED RECEPTOR 143 BY COMPUTATIONAL AND PHARMACOLOGICAL METHODS President of the jury	Beatriz Theresa Ruth Büschbell (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/11/21	Single-cell Microcapsules for Biomedical Applications (Thesis) Main arguer	Manuel Pires dos Santos (Master) Universidade de Aveiro, Portugal
2022/11/28	Using 3D Cardiac Models derived from hPSCs for Cardiac Toxicity Studies during Heart Development (Thesis) Main arguer	Tiago Alexandre Correia Nunes (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/10/13	Leveraging machine Learning to design CPP for therapeutic cargo delivery (Thesis) Main arguer	Francisco João Manteigas Duarte (Master) Universidade de Coimbra, Portugal
2022/07/13	Bioactive nanovesicles from umbilical cord blood to treat diabetic chronic wounds (Thesis) Arguer	Helena Antunes (PhD) Universidade de Coimbra, Portugal
2021/12/07	Tailoring of the cellular microenvironment to guide cell fate and functions for bone tissue engineering strategies (Thesis) Main arguer	Diana Sofia Santiago Jesus (Master) Universidade de Aveiro, Portugal
2021/11/29	mirnas in pericardial fluid and their role in cardiac fibrosis - conversations inside us and how they change our hearts (Thesis) Main arguer	Francisco Ribeiro Coelho de Melo Costa (Master) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2021/04/06	Contribution of Aging and Senescence to Intervertebral Disc Degeneration (Thesis) Main arguer	Emanuel Novais (PhD) Universidade do Minho Escola de Medicina, Portugal
2021/03	Bioencapsulamento de células estaminais e endoteliais para criação de um novo modelo in vitro de ossificação endocondral (Thesis) Main arguer	Inês de Jesus Fernandes (Master) Universidade de Aveiro, Portugal
2021/01/20	Healthy ageing: the heart of the matter is outside of the heart. (Thesis) Main arguer	Federica de Majo (PhD) Universiteit Maastricht, Netherlands
2020/12/17	Investigating the therapeutic potential of extracellular vesicles from hiPSCs and hiPSC-derived cardiac cells for heart regeneration (Thesis) Main arguer	Marta Rodrigues Oliveira (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	3D hybrid scaffolds for Tissue Engineering (Thesis) Main arguer	Sara Neves (PhD) Universidade do Porto Faculdade de Engenharia, Portugal
2018	Towards the development of potency assays and 3D inflammation models to evaluate the regenerative potential of mesenchymal/stromal cell (MSC) and MSC-derived products (Thesis) Main arguer	Raquel Cunha (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017	Vascular organ-on-a-chip platforms for disease modeling (Thesis) Arguer	João Ribas (PhD) Universidade de Coimbra, Portugal
2017	Development of a new nanostructure scaffold for neural stem/progenitor cell transplantation (Thesis) Main arguer	Tânia Vieira (PhD) Universidade Nova de Lisboa, Portugal
2017	Microengineered 3D in vitro model of human pulmonary alveoli: curvatures influence on lung epithelial cells (Thesis) Main arguer	Sara Vilabril (Master) Universidade de Coimbra, Portugal Universiteit Twente, Netherlands
2016	Bioengineering platforms to modulate the activity of smooth muscle cells derived from progeria-induced pluripotent stem cells (Thesis) Arguer	Patrícia Pitrez (PhD) Universidade do Minho, Portugal
2016	microRNA inhibitor screening: searching for angiogenesis modulators in human endothelial cells (Thesis) Main arguer	Ricardo Abreu (Master) Universidade de Coimbra, Portugal Universiteit Maastricht, Netherlands
2015	Tissue-Engineering approaches to stress urinary incontinence using acellular urethra bioscaffolds (Thesis) Main arguer	Irina Simões (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014	Engineering the microenvironment of human umbilical cord blood hematopoietic stem/progenitor cells towards efficient megakaryocytic lineage differentiation and platelet production ex-vivo (Thesis) Main arguer	Javad Hatami (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014	Modulation of induced pluripotency by substrate rigidity (Thesis) Main arguer	Heloísa Salguinho (Master) Universidade de Coimbra, Portugal
2014	A soft lithography method for patterning calcium phosphate ceramics (Thesis) Main arguer	Daniel Pereira (Master) Universidade de Coimbra, Portugal Universiteit Twente, Netherlands

Association member

	Society Organization name	Role
2020/02 - Current	Portuguese Society of Diabetology
2019/10 - Current	Portuguese Society of Stem Cells and Cell Therapy	Board member (Secretary)
2009 - Current	Member of the Portuguese Society of Stem Cells and Cellular Therapy	National Coordinator of the section "Science and technology of Stem Cells"
2017/10 - 2019/10	Portuguese Society of Stem Cells and Cell Therapy	Member and National Coordinator of the working group "Science and Technology of Stem cells"

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2022/03 - Current	Lecture to the student enrolled in the PhD program Cardiovascular Sciences. Title: cardiovascular regenerative Medicine		Universidade de Coimbra, Portugal
2021/11 - Current	Extracellular Vesicles and Regenerative Medicine	(Mestrado integrado)	Universidade de Coimbra, Portugal
2021/04/07 - Current	Lecture "Cardiovascular Regenerative Medicine"	(Doutoramento)	Universidade de Coimbra Faculdade de Medicina, Portugal
2019/10/02 - Current	Lecturer Master Biomedical Engineering - Regenerative Medicine. Two (3h) classes on Adult Stem Cells and High-Throughput Screening.	(Mestrado)	Universidade de Coimbra, Portugal
2019 - Current	Human cardiac stem cell therapy	PhD Program in Health Sciences - Faculty of Medicine, University Coimbra, Portugal	Universidade de Coimbra, Portugal
2018 - Current	Lecturer Master Biomedical Engineering - Regenerative Medicine. Two (3h) classes on Adult Stem Cells and High-Throughput Screening.	Master Biomedical Engineering (Mestrado)	Universidade de Coimbra, Portugal
2013 - Current	Organization/Responsible/Lecturer course Advanced Cell Biology	(Bacharelato)	Universiteit Twente, Netherlands
2013 - Current	Organization/Responsible/Lecturer course Advanced Cell Biology	(Mestrado)	Universiteit Twente, Netherlands
2023/10/27 - 2023/10/27	Unlocking the regenerative potential of extracellular vesicles: bioactivity enhancement through miRNA modulation	Master Biomedical Research (Mestrado integrado)
2022/10 - 2022/11	Regenerative Medicine - Master Biomedical Engineering
2021/10 - 2021/12	Regenerative Medicine - Master Biomedical Engineering	Master Biomedical Engineering (Mestrado integrado)	Universidade de Coimbra, Portugal
2019/12/09 - 2019/12/09	Lecture "Biomaterials and stem cell-based therapies"	Master Chemical Engineerting (Mestrado integrado)	Universidade de Coimbra, Portugal
2019/01 - 2019/04	Organisation of the course on Biotechnology	(Outros)	Instituto de Educação e Cidadania, Portugal
2015 - 2018	Lecturer Doctoral Programme in Ageing and Chronic Diseases	(Doutoramento)	Universidade de Coimbra, Portugal
2014 - 2017	Lecturer at the Doctoral Program Experimental Biology and Medicine	(Doutoramento)	Universidade de Coimbra, Portugal
2005 - 2013	Lecturer for Master course in Advanced Cell Biology	(Mestrado)	Universiteit Twente, Netherlands
2005 - 2013	Lecturer Bachelor Course Advanced Cell Biology	(Bacharelato)	Universiteit Twente, Netherlands

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2020 - Current	Expert for the evaluation of Research Project		Action Medical Research
2020 - Current	Expert for the evaluation of Research Project		Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
2019 - Current	Expert for the evaluation of Research Project		The Dunhill Medical Trust
2018 - Current	Expert for the evaluation of Marie Sklodowska-Curie Individual Fellowships Evaluator		EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2016 - Current	Expert for the evaluation of Grants Evaluator	Agence nationale de la recherche, France	Agence nationale de la recherche
2016 - Current	Expert for the evaluation of Grant applications Evaluator		The National Science Centre
2020/09 - 2020/11	Expert for the evaluation of Marie Sklodowska-Curie Individual Fellowships Evaluator	European Commission, Belgium
2019/10 - 2019/11	Expert for the evaluation of Marie Sklodowska-Curie Individual Fellowships Evaluator		European Commission
2017 - 2017	Expert for the evaluation of Marie Sklodowska-Curie Individual Fellowships Evaluator		EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2018	Ligação entre médicos e investigadores	Jornal Associação Portuguesa Intervenção Cardiovascular
2011	Love in the lab - tissue engineers form creative alliance;	UTNieuws
2007	Além fronteiras e ciência em Portugês - entrevista a cientistas Portugueses	Revista Mundus

Journal scientific committee

	Journal title (ISSN)	Publisher
2020 - 2023	Pharmaceutics	MDPI
2019 - 2023	Biomaterials Science	ROYAL SOC CHEMISTRY
2022 - 2022	Materials	MDPI
2022 - 2022	Nanoscale Horizons	Royal Soc Chemistry
2022 - 2022	Advanced Science	Wiley
2022 - 2022	Plos One	PUBLIC LIBRARY SCIENCE
2021 - 2021	Advanced Healthcare Materials	Wiley
2019 - 2021	Cells	MDPI
2020 - 2020	Theranostics	IVYSPRING INT PUBL
2020 - 2020	International Journal of Molecular Sciences	MDPI
2020 - 2020	Advanced Therapeutics	Wiley
2019 - 2019	Journal of Clinical Medicine	MDPI
2018 - 2018	Frontiers in Bioengineering and Biotechnology	Frontiers Media SA
2016 - 2017	Biomaterials	ELSEVIER SCI LTD
2016 - 2016	BMC MUSCULOSKELETAL DISORDERS	BMC
2015 - 2015	BMC Biotechnology	BMC
2011 - 2014	ECM Journal	AO RESEARCH INSTITUTE DAVOS-ARI

Mentoring / Tutoring

	Topic	Student name
2017/06 - 2017/08	Supervision of short-term lab rotations for students enrolled in PhD programs	Mariana Branco

Distinctions

Award

2023	Best oral communication, Sociedade Portuguesa Diabetologia Sociedade Portuguesa de Diabetologia, Portugal
2020	FCT Scientific Employment Stimulus Award Fundação para a Ciência e a Tecnologia, Portugal
2019	Best poster award, EMBO advanced course in extracellular vesicles, Heidelberg, Germany, April 2018 European Molecular Biology Laboratory, Germany
2019	Best Oral Communication, 3rd National Congress of Biomedical Laboratory Sciences
2012	Travel Award - TERMIS World Congress Tissue Engineering and Regenerative Medicine International Society, United States
2011	Best Paper (2010-2011) from the Dutch Bone and Mineral Society Dutch Bone and Mineral Society, Netherlands
2010	Science Factor - Best Scientific Idea Universiteit Twente, Netherlands