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Identification

Personal identification

Full name
CLÉVIO DAVID RODRIGUES NÓBREGA

Citation names

  • Nóbrega, Clévio David Rodrigues

Author identifiers

Ciência ID
C510-7F41-BAF8
ORCID iD
0000-0002-8312-5292

Email addresses

  • cdnobrega@ualg.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Education
Degree Classification
2022
Concluded
 Ciências Biomédicas (Título de Agregado)
Universidade do Algarve, Portugal
 Aprovado
2002 - 2007
Concluded
 Biologia Molecular e Citogenética (Doutoramento)
Universidade da Madeira, Portugal
"A multilocus comparative study of nucleotide variation in Drosophila madeirensis and the close relative D. subobscura: Insights into the speciation process of D. madeirensis" (THESIS/DISSERTATION)
 aprovado distinção e louvor
1995 - 2000
Concluded
 Biologia, Ramo Científico (Licenciatura)
Universidade da Madeira, Portugal
"Análise genética do isolamento reprodutor entre D. subobscura e D. madeirensis. Estudo de 3 genes: yellow, antennae color e RNA polimerase II do cromossoma X" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2021 - Current Principal Investigator (Research) Universidade do Algarve, Portugal
Algarve Biomedical Center Research Institute (ABC-Ri), Portugal
2016 - 2020 Principal Investigator (Research) Universidade do Algarve, Portugal
Centro de Investigação em Bioomedicina, Portugal
2007/10 - 2016/08 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01 - 2007/10 Postdoc (Research) Universitat de Barcelona, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2025/12/02 - Current Full Professor (University Teacher) Universidade do Algarve, Portugal
2024/12/17 - Current Associate Professor (University Teacher) Universidade do Algarve, Portugal
2016/09 - 2024/12/16 Assistant Professor (University Teacher) Universidade do Algarve, Portugal
2015/09 - 2016/08 Invited Assistant Professor (University Teacher) Universidade do Algarve, Portugal

Positions / Appointments

Category
Host institution 		Employer
2024 - Current Vice-President Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
2022/10 - Current Executive Board Director Laboratório Colaborativo do Algarve Biomedical Center: soluções integradas para o envelhecimento e rejuvenescimento (ABC-CoLAB), Portugal
Laboratório Colaborativo do Algarve Biomedical Center: soluções integradas para o envelhecimento e rejuvenescimento (ABC-CoLAB), Portugal
2021/06 - Current President of the Pedagogic Council Universidade do Algarve, Portugal
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2021 - Current Director Universidade do Algarve, Portugal
Algarve Biomedical Center Research Institute (ABC-Ri), Portugal
2016 - Current Conselho científico Universidade do Algarve, Portugal
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018/12 - 2020/12/31 Director Universidade do Algarve, Portugal
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Projects

Grant

Designation Funders
2024/09/01 - Current AgeT ech - Investigação de Novos Compostos para o Desenvolvimento Inovador de Produtos Cosméticos de AntiEnvelhecimento
AgeTech
Principal investigator
Universidade do Algarve, Portugal
Ongoing
2021/09/01 - Current Assessment of experimental therapies in pre-clinical studies of Cockayne Syndrome
#431
Ongoing
2023/03/01 - 2024/08/31 Estudo do BUB1 em neurodesenvolvimento: identificação de novas funções
10.54499/2022.01028.PTDC
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2021/10/31 Overexpression of the RNA-binding protein GXXXX as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases
22424
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
 AFM-Téléthon
Concluded
2019/01 - 2019/12 CNC. IBILI
154730UID
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/03/01 - Current AdvGT-CSB: Advancing the development of a gene therapy for Cockayne Syndrome type B
#457 AdvGT-CSB
Principal investigator
Algarve Biomedical Center Research Institute (ABC-Ri), Portugal
 Viljem Julijan Association for Children with Rare Diseases
Ongoing
2022/06/01 - Current CureCSB - Development of a Gene-Replacement Therapy for Cockayne Syndrome Type B
#438 CureCSB
Principal investigator
Algarve Biomedical Center Research Institute (ABC-Ri), Portugal
Ongoing
2021/04/01 - Current ALgarve Fit Ageing Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável
072586
Researcher
Comissão de Coordenação e Desenvolvimento Regional do Algarve
Ongoing
2021/01/01 - Current Investigação de terapias experimentais em estudos pré-clínicos para o Síndroma de Cockayne
431#ABC-RI)
Principal investigator
Ongoing
2019/03/01 - Current Overexpression of the RNA-binding protein X as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases.
#22424
Principal investigator
The French Muscular Dystrophy Association (AFM)
Concluded
2018/10/01 - Current The role of stress granules in Polyglutamine disease: from pathogenesis to molecular therapy
"PTDC/MED-NEU/29480/2017 ALG-01-0145-FEDER-29480 ""SeGrPolyQ"""
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2025/02/03 - 2026/08/02 Testing efficacy and safety of a gene therapy for Cockayne syndrome type B in patient-derived cell models
2023.15884.PEX
10.54499/2023.15884.PEX
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 ALFA Score - ALgarve Fit Aging Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável
ALG-01-0145-FEDER-072586
Concluded
2022/01/01 - 2023/06/30 Identificação de alvos de S-sulfidração na síndrome de Down: a função da sinalização pelo gasotransmissor sulfureto de hidrogénio H2S no desenvolvimento neuronal
EXPL/MED-NEU/1240/2021
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/01/01 - 2021/12/31 Using an OMICS approach to found new genetic profiles associated with obesity
NA
Researcher
Instituto de Salud Carlos III
Concluded
2020/05/11 - 2020/08/11 Development of a new assay do detect SARS-CoV-2 directly from clinical samples
126_596760136
Principal investigator
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/02 - 2020/01 Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK
ZUNIALGA
Principal investigator
Ataxia UK
Concluded
2017/01/01 - 2017/12/31 Integración de varias omicas para el estudio de la obesidad
NA
Researcher
Fundación Investigación Hospital General Universitario de Valencia
2015/03 - 2017/03 Ataxin-2 as a new molecular target in Machado-Joseph disease: from translation regulation to disease alleviation
18876
Principal investigator
The French Muscular Dystrophy Association (AFM)
Concluded
2014/01/01 - 2015/12/31 The role of ataxin-2 in Machado-Joseph disease: a molecular therapy approach with viral vectors.
NA
Principal investigator
National Ataxia Foundation
Concluded
2013/03 - 2015/02 Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
Provided by PTCRIS: 125208
125208
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/03 - 2014/04 Silencing Machado-Joseph Disease through the systemic route
125367
Provided by PTCRIS: 125367
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/02 - 2013/04 The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors
Provided by PTCRIS: 70384
70384
99307
Provided by PTCRIS: 99307
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/01/01 - 2011/12/31 Role of the autophagy-related protein Beclin-1 in Machado-Joseph disease
NA
Researcher
The French Muscular Dystrophy Association (AFM)
Concluded
2010/01/01 - 2010/12/31 Modulation of autophagy as a novel therapeutic strategy for Machado-Joseph disease.
NA
Researcher
National Ataxia Foundation
Outputs

Publications

Book
  1. Nóbrega, Clévio David Rodrigues ; Liliana Mendonça; Carlos A Matos. A Handbook of Gene and Cell Therapy. Springer. 2020.
Book chapter
  1. M. Codêsso, José; A. Matos, Carlos; Nóbrega, Clévio. "RNA Interference Applications for Machado-Joseph Disease". In RNA Therapeutics - History, Design, Manufacturing, and Applications [Working Title]. IntechOpen, 2022.
    10.5772/intechopen.109261
  2. Albuquerque, David; Carmo-Silva, Sara; Álvarez-Vaca, Daniel; Aveleira, Célia; Nóbrega, Clévio. "Role of Mitochondrial Dysfunction in Human Obesity". In Handbook of Mitochondrial Dysfunction, 379-388. CRC Press, 2019.
    10.1201/9780429443336-30
  3. Albuquerque, David; Manco, Licínio; Nóbrega, Clévio; Albuquerque, D.; Manco, L.; Nóbrega, C.. "Molecular Biology of Human Obesity: Non-epigenetics in Comparison with Epigenetic Processes". In Handbook of Nutrition, Diet, and Epigenetics, 1-18. Springer International Publishing, 2017.
    10.1007/978-3-319-31143-2_7-1
  4. Albuquerque, David; Manco, Licínio; Nóbrega, Clévio. "Genetics of Human Obesity". In Obesity, 87-106. Springer International Publishing, 2016.
    10.1007/978-3-319-19821-7_7
  5. Nóbrega, Clévio David Rodrigues. "Genetic contribution: Common forms of Obesity". In Molecular mechanisms underpinning the development of obesity, 37-56. US: Springer, 2015.
    Published
  6. Albuquerque, David; Manco, Licínio; Nóbrega, Clévio; Nóbrega, Clévio David Rodrigues. "Epigenetics of Human Obesity: A Link Between Genetics and Nutrition". In Molecular Mechanisms Underpinning the Development of Obesity, 101-127. US: Springer International Publishing, 2014.
    Published • 10.1007/978-3-319-12766-8_8
  7. Nobrega, Clevio; de Almeida, L. P.. "Machado-Joseph Disease / Spinocerebellar Ataxia Type 3". In Spinocerebellar Ataxia, 103-138. Croatia: InTech, 2012.
    Published • 10.5772/28576
Conference abstract
  1. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Sofia M. Calado; Matos, Carlos A. Corresponding author: Matos, Carlos A. "Generation of a CSB-iPSC disease model as a platform to develop gene therapy approaches for Cockayne Syndrome type B". Paper presented in Meeting of the Portuguese Society of Pharmacology (SPF Meeting), Lisbon, 2024.
    Published
  2. Afonso, Inês T.; Lima, Patrícia; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Ataxin-2 pathological features are altered by the aging process". Paper presented in 25th Annual Meeting of the Portuguese Society of Human Genetics, Porto, 2022.
    Published
  3. Nóbrega, Clévio David Rodrigues. "PERMANENT INACTIVATION OF THE ATXN3 GENE: A POSSIBLE THERAPEUTIC APPROACH FOR MACHADO-JOSEPH DISEASE". 2021.
    Published • 10.1097/MD.0000000000023585
  4. Nóbrega, Clévio David Rodrigues. "MITIGATING THE PROGEROID PHENOTYPE: A GENE DELIVERY STRATEGY TO IMPROVE PROGERIN-ASSOCIATED ABNORMALITIES". 2021.
    Accepted • 10.1097/MD.0000000000023585
  5. Nóbrega, Clévio David Rodrigues. "AN RNA BINDING PROTEIN ALLEVIATES PATHOLOGY IN TWO DIFFERENT MOUSE MODELS OF POLYGLUTAMINE DISEASES". 2021.
    Published • 10.1097/MD.0000000000023585
  6. Nóbrega, Clévio David Rodrigues. "AUTOPHAGY IMPAIRMENT IN SPINOCEREBELLAR ATAXIA TYPE 2: FIRST EVIDENCES AND A POTENTIAL THERAPEUTIC STRATEGY". 2021.
    10.1097/MD.0000000000023585
  7. Nóbrega, Clévio David Rodrigues. "SILENCING ATXN2 EXPRESSION USING CRISPR/CAS9". 2021.
    Published • 10.1097/MD.0000000000023585
  8. Marcelo, Adriana; Tomé S; Carmo-Silva S; Teixeira, Diogo; Ferreira, M; Matos, CA; Koppenol, Rebekah; de Almeida LP; Nóbrega, Clévio David Rodrigues. "RNA-binding proteins as potential therapeutic targets for Polyglutamine diseases". Paper presented in L Reunião Anual da Sociedade Portuguesa Farmacologia, Coimbra, 2020.
  9. Nóbrega, Clévio David Rodrigues. "CYP46A1- gene therapy improves Machado-Joseph disease in mouse models". 2020.
    Published
  10. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 prevents obesity through the regulation of the circadian clock". 2020.
    Published • 10.1111/obr.13115
  11. Afonso, Inês T.; Silva, Ana Carolina; Henriques, Carina; Lopes, Miguel; Baganha, Rafael; Lima, Patricia; Koppenol, Rebekah; et al. "mixCapAAV1/2 Vector: Distribution, Spreading and Tropism Analysis in Normal Mice". Paper presented in 24th Annual Meeting of the PortugueseSociety for Human Genetics (SPGH), Lisboa, 2020.
  12. Nóbrega, Clévio David Rodrigues. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy". 2019.
    Published
  13. Carmo-Silva, Sara (9D11-2BDFA256); Nóbrega, Clévio David Rodrigues ; Ferreira-Marques, Marisa; Pulst, Stefan M; Pereira de Almeida, Luis ; Cavadas, Claudia. "Hypothalamic ataxin-2: Resetting the clock on obesity". Paper presented in 26th European Congress on Obesity, Gasglow, 2019.
    Published
  14. Nóbrega, Clévio David Rodrigues. "TALEN and CRISPR Gene-Editing for Treatment of Machado-Joseph Disease". 2018.
    Published
  15. Nóbrega, Clévio David Rodrigues. "Machado-Joseph disease: from pathogenic mechanisms to therapeutic strategies". 2017.
    Published
  16. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". 2016.
    Published • 10.1016/j.npep.2015.11.035
  17. Nóbrega, Clévio David Rodrigues. "Role of MicroRNA deregulation in Machado-Joseph disease". 2015.
    https://doi.org/10.1016/S1525-0016(16)34191-0
  18. Nóbrega, Clévio David Rodrigues. "MicroRNA-139-5p: a tool for metastasis and chemotherapeutic resistance control in pancreatic adenocarcinoma". 2014.
    Published
  19. Osokina, Irina. "Association study of several common polymorphisms with obesity and obesity-related traits among Portuguese children". 2014.
    Published • 10.1136/archdischild-2019-epa.639
  20. Nóbrega, Clévio David Rodrigues. "Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease". 2013.
    Published
  21. Albuquerque, David; Jacobs, J; Nóbrega, Clévio David Rodrigues; Hanen, Samouda; Manco, Licínio; Nóbrega, Clévio David Rodrigues. "The common rs9939609 polymorphism of the Fat Mass and Obesity-associated (FTO) gene is associated with obesity in Portuguese children". Paper presented in 19th European Congress on Obesity (ECO2012), Lyon, 2012.
    Published • 10.1159/000228822
  22. Nóbrega, Clévio David Rodrigues. "Silencing of mutant ataxin-3 rescues motor deficits and neurological abnormalities in Machado-Joseph disease transgenic mice". 2011.
    Published
  23. Nóbrega, Clévio David Rodrigues. "Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease". 2010.
    Published
  24. Nóbrega, Clévio David Rodrigues. "Inhibition of mutant ataxin-3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease". 2009.
    Published
Conference poster
  1. Pestana, Daniel; Cardoso, Candida; Ramos, Mónica; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Nóbrega, Clévio David Rodrigues ; Justin O'Sullivan; Pedro Castelo-Branco. Corresponding author: Pestana, Daniel. "Ageing Well in Algarve: A Clinical, Molecular and Geospatial integrative analysis into Elderly Health and fitness". Paper presented in Encontro Ciência 2025, 2025.
  2. GALA, VIKTOR; Esteves, F; Martins, B.; Paulino, R.; Couto, F.; Matos, I.; Silva, N.; et al. "Screening of marine biocompounds as potential adjuvant therapy in Cockayne syndrome and aging". Paper presented in Encontro Ciência 2025, 2025.
  3. Esteves, F; Paulino, R.; Silva, N.; GALA, VIKTOR; Martins, B.; Matos, I.; Couto, F.; et al. "Combating cellular aging: marine bioactives and drug repurposing for DNA damage repair". Paper presented in Longevity Summit Dublin, 2025.
  4. Costa, Rafael; Outeiro, Tiago; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Extracellular Vesicles as Carriers of ATXN2 mRNA: Implications for SCA2 Progression". Paper presented in Portuguese Network on Extracellular Vesicles (PNEV) 2025, 2025.
  5. Esteves, F; Paulino, R.; GALA, VIKTOR; Martins, B.; Matos, I.; Couto, F.; Silva, N.; Nóbrega, Clévio David Rodrigues ; Roberto, V.. "Innovative anti-aging approaches: Marine bioactives and drug repurposing to repair DNA damage and modulate cellular senescence". Paper presented in 89th Cold Spring Harbor Laboratory Symposium on Quantitative Biology, Senescence & Aging, 2025.
  6. Costa, Rafael; Outeiro, Tiago; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "ATXN2 mRNA shuttling to exosomes: a mechanism underlying pathogenesis?". Paper presented in Gordon Research Conference on CAG Triplet Repeat Disorders 2025, 2025.
  7. CORREIA, ÉDI; Duarte, Isabel; Nóbrega, Clévio David Rodrigues ; Hoffmann, Carolin. "Complement Gene Expression in the Fetal Brain after Maternal Immune Activation in a rodent model". Paper presented in SPI 50 - L Annual Meeting Sociedade Portuguesa de Imunologia, 2025.
  8. Nóbrega, Clévio David Rodrigues ; Moreira-Gomes, Tiago; Marcelo, Adriana; Codêsso, José Miguel; Afonso, Inês T.; Costa, Rafael G; Vaz, Adriana; et al. "RBPome - RNA-binding proteins in Machado-Joseph disease: from pathogenesis to therapy". Paper presented in 2025 MJD International Research Conference, 2025.
  9. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Sofia M. Calado; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Depletion of Trmt2a alleviates pathological features in a MJD/SCA3 mouse model". Paper presented in 2025 MJD International Research Conference, 2025.
  10. Afonso, Inês T.; Brito, David; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "Activity-Induced Inhibitors of Death: A Potential Therapeutic Target for SCA2 and SCA3". Paper presented in ICAR 2024, 2024.
  11. Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Rajado, Ana Teresa; Nóbrega, Clévio David Rodrigues ; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. Corresponding author: Araújo, Inês Maria. "Oxidative profile of a cohort of young versus aged individuals in the Algarve region". Paper presented in HEAT-NET Frontiers in Neurodegeneration: from bench to bedside, 2024.
  12. Afonso, Inês T.; Brito, David; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "Activity regulated inhibitor of death gene expression: the case of spinocerebellar ataxia type 2 and type 3". Paper presented in HEAT-NET meeting 2024, 2024.
  13. Paulino, Rodrigo; Nóias Diana; Afonso-Reis, Ricardo; Costa, Rafael G; Couto Filipa; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Early stage, combating neurodegeneration induced by DNA damage through pharmacological testing in vitro model.". Paper presented in Harvard European Alumini Training Network Meeting, 2024.
  14. Matos, Carlos A; Conceição, J.; Nóbrega, Clévio David Rodrigues. "History and innovation in the teaching of Gene and Cell Therapy at the University of Algarve". Paper presented in 19.º Congresso da Sociedade Portuguesa de Neurorradiologia Diagnóstica e Terapêutica (SPNR), 2024.
  15. Afonso-Reis, Ricardo; Paulino, Rodrigo; Adriana Vaz; Miguel Sene-Esteves; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "AAV-based ERCC6 supplementation as a potential gene therapy for Cockayne Syndrome". Paper presented in European Society of Cellular and Gene Therapy (ESCGT) - Rome, 2024.
  16. Paulino, Rodrigo; Britto David; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "'Optimising Adeno-Associated Virus Delivery Routes for Efficient Gene Therapy Targeting the Central Nervous System". Paper presented in European Society of Cellular and Gene Therapy, Rome, 2024.
  17. Rafael G. Costa; Matos, Carlos A; Outeiro, Tiago; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Small EVs as molecular carriers: ATXN2 mRNA spreading recapitulates neuropathological hallmarks of spinocerebellar ataxia type 2". Paper presented in Gordon Research Conference on Extracellular Vesicles, 2024.
  18. Afonso, Inês T.; Brito, David; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "ALTERATIONS IN ACTIVITY REGULATED INHIBITOR OF DEATH GENE EXPRESSION IN SPINOCEREBELLAR ATAXIA TYPE 2 AND TYPE 3". Paper presented in FENS Forum 2024, 2024.
  19. Conceição, André; Filipa Couto; Brito, David V.C.; Koppenol, Rebekah; Nóbrega, Clévio David Rodrigues. "From Stress Response to Disease Mechanism: Exploring Stress Granules in Spinocerebellar Ataxia Type 2". Paper presented in Federation of European Neuroscience Societies Meenting Viena, 2024.
  20. Costa, Rafael G; Martins, Jéssica; Matos, Carlos A; Outeiro, Tiago; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Mechanisms of Spinocerebellar Ataxia Type 2 Pathogenesis: Insights from Small Extracellular Vesicles". Paper presented in FENS Forum 2024, 2024.
  21. Paulino, Rodrigo; Nóias Diana; Afonso-Reis, Ricardo; Costa, Rafael G; Couto Filipa; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Assesment of Neuroprotective drug efficacy in repairing chemically induced DNA damage.". Paper presented in ESN-ISN Greece, 2024.
  22. Koppenol, Rebekah; de Almeida, Luís Pereira; Carlos Adriano Albuquerque Andrade de Matos; Nóbrega, Clévio David Rodrigues. "CRISPR-mediated approaches for ATXN2 knockdown in SCA2 models of disease". Paper presented in Fens Forum 2024, 2024.
  23. joana Rodrigues; David Brito; Nóbrega, Clévio David Rodrigues ; Sónia Simão; Vitorino, Marta; Araújo, Inês Maria. "Characterization of Adult Neurogenesis in Acomys cahirinus by Lineage Tracing Analysis". Paper presented in IX Clinical Biochemistry Workshop, 2024.
  24. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Mitigation of polyQ-induced toxicity through depletion of Trmt2a in a MJD/SCA3 mouse model". Paper presented in Federation of European Neuroscience Societies (FENS) Forum 2024, 2024.
  25. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Absence of RNA chaperone improves motor function and mitigates neuronal cell death in spinocerebellar ataxia type 3". Paper presented in Gordon Conference on Cell Death (Harnessing Cell Death Mechanisms in Health and Disease), 2024.
  26. Brito, David V.C.; Afonso, Inês T.; Sofia M. Calado; Yand, Jin; Bading, H.; Nóbrega, Clévio David Rodrigues. "NMDAR-TRPM4 coupling drives neurotoxicity and disease progression in models of Spinocerebellar Ataxias". Paper presented in FENS, 2024.
    10.1002/1878-0261.13682
  27. Koppenol, Rebekah; Cristiana R. Madeira; Sofia M. Calado; Carlos A. Matos; Afonso-Reis, Ricardo; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Development and characterization of a novel SCA2 patient-derived induced pluripotent stem cell model as a tool to investigate therapeutic strategies". Paper presented in ICAR 2024, 2024.
  28. Afonso, Inês T.; Brito, David V.C.; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "Activity-induced genes expression is impaired in polyglutamine spinocerebellar ataxias". Paper presented in 27th SPGH Annual Meeting, 2023.
  29. Conceição, André; Koppenol, Rebekah; Afonso, Inês T.; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Unveiling SCA2 disease phenotype: a new mouse model reveals motor deficits and neuropathology". Paper presented in Sociedade Portuguesa de Genética Humana, 2023.
  30. Joana Rodrigues; David Brito; Nóbrega, Clévio David Rodrigues ; Simão, Sónia; Vitorino, Marta; Araújo, Inês Maria. "Illuminating Neurogenesis: Unveiling Acomys cahirinus newborn neurons by lineage tracing imaging.". Paper presented in Spanish and Portuguese Advanced Optical Microscopy Meeting (SPAOM2023), 2023.
  31. Lopes, Sara Monteiro; Miguel M. Lopes; Nobre, Rui Jorge; Vasconcelos-Ferreira, Ana; Pereira, Dina; Fernandes, Ana Rita; Barros, Maria Inês; et al. Corresponding author: Pereira de Almeida, Luis. "Targeting the ATXN3 gene with CRISPR-Cas9 for the therapy of Machado-Joseph disease". Paper presented in 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  32. Afonso, Inês T.; Koppenol, Rebekah; Conceição, André; Renato Viera; Paulino, Rodrigo; Lorenzo Mirapalheta; Carlos A. Matos; Nóbrega, Clévio David Rodrigues. "From the molecular hallmarks to motor behavior: characterization of a novel transgenic mouse model for Spinocerebellar ataxia type 2". Paper presented in ISN-ESN 2023 Meeting, 2023.
  33. Paulino, Rodrigo; Afonso-Reis, Ricardo; Costa, Rafael G; Filipa Costa; Cristiana Madeira; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Evaluation of DNA damage on neuronal cells through single cell gel electrophoresis". Paper presented in Ciência 2023, 2023.
  34. Marcelo, Adriana; Afonso, Inês T.; Ana Teresa Rajado; Rafael G. Costa; Afonso-Reis, Ricardo; Luís Pereira Almeida; Nóbrega, Clévio David Rodrigues. "Tackling Machado-Joseph disease through stress granules: is protein CARHSP1 a potential target for therapeutics?". Paper presented in FENS Regional Meeting 2023, 2023.
  35. Marcelo, Adriana; Afonso, Inês T.; Ana T. Rajado; Rafael G. Costa; Afonso-Reis, Ricardo; Pereira de Almeira, Luis; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Stress granule protein CARHSP1 as a potential therapeutic strategy for MJD". Paper presented in European Neuroscience Conference by Doctoral Students 2023, 2023.
  36. Paulino, Rodrigo; Afonso-Reis, Ricardo; Costa, Rafael G; Couto Filipa; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Development and optimization of a comet assay to evaluate DNA damage in neuronal cells.". Paper presented in Fens Regional Meeting Conference, 2023.
  37. Paulino, Rodrigo; Afonso-Reis, Ricardo; Costa, Rafael G; Couto Filipa; Madeira Cristiana; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Comet assay: optimization and evaluation of DNA damage in neuronal cells.". Paper presented in European Neuroscience Conference by Doctoral Students, 2023.
  38. Madeira Cristiana; Afonso-Reis, Ricardo; Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues ; Sofia M. Calado; Matos, Carlos A. "Neuronal cultures differentiated from patient-derived induced pluripotent stem cells as a novel model of Cockayne syndrome B.". Paper presented in European Neuroscience Conference by Doctoral Students, 2023.
  39. Afonso-Reis Ines; Koppenol, Rebekah; Conceição, André; Vieira Romulo; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "the molecular hallmarks to motor behavior: characterization of a novel transgenic mouse model for Spinocerebellar ataxia type 2". Paper presented in ISN-ESN, 2023.
  40. Koppenol, Rebekah; Afonso-Reis, Ricardo; Pereira de Almeida, Luís; Nóbrega, Clévio David Rodrigues. "Tackling spinocerebellar ataxia type 2: targeting the ATXN2 gene with CRISPR-Cas-based silencing strategies". Paper presented in Fens Regional Meeting, 2023.
  41. Madeira, Cristiana R; Afonso-Reis, Ricardo; Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A; Sofia M. Calado. "Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells". Paper presented in FENS Regional Meeting 2023 (FRM 2023), 2023.
  42. Paulino, Rodrigo; Afonso-Reis, Ricardo; Cristiana R. Madeira; Nóbrega, Clévio David Rodrigues. "Evaluation of DNA damage on neuronal cells through single cell gel electrophorasis". Paper presented in Ciência, 2023.
  43. Conceição, André; Koppenol, Rebekah; Inês Afonso; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos; Nóbrega, Clévio David Rodrigues. "A novel SCA2 transgenic mouse model displays disease-associated phenotype.". Paper presented in FENS Regional Meeting 2023 ¿ Algarve, 2023.
  44. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Translational regulation: exploring the impact of TRMT2A in Spinocerebellar ataxia type 3 /Machado-Joseph Disease". Paper presented in 9th European Neuroscience Conference by Doctoral Students (ENCODS), 2023.
  45. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Silencing Trmt2a as a novel therapeutic target in Spinocerebellar ataxia type 3 /Machado-Joseph Disease". Paper presented in Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  46. Couto, Filipa Lopes; Codêsso, José Miguel; Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues. "Modulation of the RNA binding protein HSPA8 in Spinocerebellar Ataxia type 2". Paper presented in Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  47. Couto, Filipa Lopes; Codêsso, José Miguel; Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues. "Overexpression of the RNA binding protein HSPA8 in Spinocerebellar Ataxia type 2". Paper presented in 9th European Neuroscience Conference by Doctoral Students (ENCODS), 2023.
  48. Codêsso, José Miguel; Brito, David V.C.; Mendonça, Liliana; Pereira de Almeida, Luis; Nóbrega, Clévio David Rodrigues. "Unraveling the role of the RBP HSPA8 in Spinocerebellar Ataxia type 3: from pathogenesis to therapeutics". Paper presented in Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  49. Rafael G. Costa; Afonso, Inês T.; Afonso-Reis, Ricardo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "The role of a stress granules' component as a modulator of progerin's expression: a prospective approach to slow down accelerated aging in HGPS cells". Paper presented in Ageing Without Borders 2022, 2022.
  50. Marcelo, Adriana; Afonso, Inês T.; Rajado, Ana Teresa; Costa, Rafael G; Afonso-Reis, Ricardo; de Almeida, Luís Pereira; Nóbrega, Clévio David Rodrigues. "Modulation of stress granules components as a therapeutic approach for spinocerebellar ataxia type 3". Paper presented in V Encontro Anual do Algarve Biomedical Center, 2022.
  51. Koppenol, Rebekah; Conceição, André; Afonso, Inês T.; Afonso-Reis, Ricardo; Costa, Rafael G; Nóbrega, Clévio David Rodrigues. "Motor phenotype characterization of a new transgenic mouse model for Spinocerebellar ataxia type 2". Paper presented in V Annual Meeting of the Algarve Biomedical Center, 2022.
  52. Rajado, Ana Teresa; Raquel P. Andrade; Apolónio, Joana ; Inês Maria Pombinho de Araújo; Brito, David V.C.; Sofia M. Calado; Esteves, Filipa; et al. "ALFA Score - Algarve Fit Ageing Score". Paper presented in ABC-Days, 2022.
  53. Rafael G. Costa; Carlos A. Matos; Nóbrega, Clévio David Rodrigues. "ATXN2 spreading in spinocerebellar ataxia type 2: could extracellular vesicles contribute to disease progression?". Paper presented in ABC Days 2022, 2022.
  54. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "A expressão da proteína G3BP1 reduz as anomalias neuropatológicas e motoras em modelos da Ataxia espinocerebelosa, tipo 3". Paper presented in Congresso SPDMov 2022, 2022.
  55. Adriana Marcelo; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David; Costa, Rafael G; Ana Rosa; Alves-Cruzeiro, João; et al. "Autophagy induction mitigates Spinocerebellar ataxia type 2 disease hallmarks". Paper presented in Congresso da SPDMov 2022, 2022.
  56. Maria Conceição Pito; Pinheiro, Marina; Joana Magalhães; Nóbrega, Clévio David Rodrigues. "Lipid Nanoparticles as Drug Delivery Systems of Rifampicin for the Treatment of Tuberculosis". Paper presented in MEEting 2022, 2022.
  57. Koppenol, Rebekah; Afonso-Reis, Ricardo; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio David Rodrigues. "Development of CRISPR-Cas-based strategies for spinocerebellar ataxia type 2". Paper presented in ESGCT 29th congress, 2022.
  58. Afonso, Inês T.; Patrica Lima; Carlos A Matos; Nóbrega, Clévio David Rodrigues. "Impact of aging in neuropathological hallmarks associated with the expression of mutant ATAXIN-2". Paper presented in Sociedade Portuguesa de Neurociências 2021, 2021.
  59. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Codêsso, José Miguel; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "G3BP1 expression mitigates pathological phenotype in mouse models different polyglutamine diseases". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  60. Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V.C.; Costa, Rafael G; Ana Rosa; Alves-Cruzeiro, João; et al. "From molecular mechanisms to therapy: a new lentiviral mouse model for Spinocerebellar ataxia type 2". Paper presented in XVII Meeting of Portuguese Society for Neuroscience (SPN 2021), 2021.
  61. Afonso-Reis, Ricardo; Koppenol, Rebekah; Conceição, André; Teixeira, Diogo; Marcelo, Adriana; Tomé, Sandra; Carmo-Silva, Sara; et al. "ASSESSING THE ROLE OF DIFFERENT G3BP1 REGIONS IN THE MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN SCA2 AND SCA3 DISEASE MODELS". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  62. Brito, David V.C.; Afonso, I; Matos, Carlos A; Hilmar Bading; Nóbrega, Clévio David Rodrigues ; Carlos A Matos. "Targeting the NMDAR/TRPM4 complex as a novel therapeutic strategy for polyglutamine spinocerebellar ataxias type 3 and 2". Paper presented in IV JORNADAS Algarve Biomedical Center, 2021.
  63. Afonso-Reis, Ricardo; Koppenol, Rebekah; Conceição, André; Teixeira, Diogo; Marcelo, Adriana; Tomé, Sandra; Carmo-Silva, Sara; et al. "MAPPING THE DOMAINS OF RBP-X TOWARDS MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN POLYGLUTAMINE DISEASE MODELS". Paper presented in IV Jornadas Algarve Biomedical Centre, 2021.
  64. Afonso, Inês T.; Patrícia Lima; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Is mutant ataxin-2 aggregation modulated by aging?". Paper presented in IV JORNADAS ALGARVE BIOMEDICAL CENTER, 2021.
  65. Marcelo, Adriana; Ana Rosa; Alves-Cruzeiro, João; Ferreira, Benedita; Afonso-Reis, Ricardo; Afonso, Inês T.; Henriques, Carina; et al. "Study of Autophagy in Spinocerebellar Ataxia Type 2 Models: From Dysfunction to a Therapeutic Approach". Paper presented in JCB-JEM Symposium, 2021.
  66. Rafael G. Costa; Afonso, Inês T.; Aveleira, Célia; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Development of a gene-based strategy as a potential therapy for Hutchinson-Gilford Progeria Syndrome". Paper presented in AIMS meeting 2021 Research Competition, 2021.
  67. Afonso, Inês T.; Carolina Silva, Ana; Henriques, Carina; Lopes, Miguel; Baganha, Rafael; Lima, Patrícia; Kopenol, Rebekah; et al. "Brain distribution, spreading and tropism of a recently developed gene delivery system - mixCapAAV1/2 vector". Paper presented in AIMS meeting 2021 Research Competition, 2021.
  68. Brito, David V.C.; Afonso, I; Matos, Carlos A; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "Targeting the NMDAR/TRPM4 complex as a novel therapeutic strategy for polyglutamine spinocerebellar ataxia type 2". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  69. Koppenol, Rebekah; Conceição, André; Afonso, Inês T.; Rajado, Ana Teresa; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Generation of a novel transgenic mouse model of spinocerebellar ataxia type 2 expressing mutant ATXN2 in cerebellar Purkinge cells". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  70. Aveleira, Célia; Ferreira-Marques, M; Vinhas, Ana Catarina; Carvalho, André; Nóbrega, Clévio David Rodrigues ; Cavadas, Claudia. "The effect of a novel caloric restriction mimetic on neurogenesis regulation in the hypothalamus". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021.
  71. Rafael G. Costa; Afonso, Inês T.; Célia Aveleira; Carlos A. Matos; Nóbrega, Clévio David Rodrigues. "Development of a gene-bases strategy as a potential therapy for Hutchinson-Gilford Progeria Syndrome". Paper presented in AIMS meeting 2021 Research Competition, 2021.
  72. Conceição, André; Koppenol, Rebekah; Tomé, Sandra; Carmo-Silva, Sara; Ferreira, Marco; Teixeira, Diogo; Matos, Carlos A; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio David Rodrigues. "A RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Paper presented in 24th Anual Meeting of Portuguese Human Genetics Society, 2020.
  73. Nóbrega, Clévio David Rodrigues. "Silencing of CypX gene in the hypothalamus and its impact on whole-body metabolism". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020.
  74. Nóbrega, Clévio David Rodrigues. "A lentiviral genetic mouse model for spinocerebellar ataxia type 2". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020.
  75. Nóbrega, Clévio David Rodrigues. "RBP-X modulates progerin levels and ameliorates its associated abnormalities in cellular models of HGPS". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020.
  76. Nóbrega, Clévio David Rodrigues. "Mitigating the Progeroid Phenotype: A Gene Delivery Strategy to Improve Progerin-Associated Abnormalities". Paper presented in 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  77. Nóbrega, Clévio David Rodrigues. "Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model". Paper presented in FENS 2020 Virtual Forum, 2020.
  78. Nóbrega, Clévio David Rodrigues. "An RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Paper presented in 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  79. Nóbrega, Clévio David Rodrigues. "Autophagy Impairment in Spinocerebellar Ataxia Type 2: First Evidences and a Potential Therapeutic Strategy". Paper presented in 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  80. Nóbrega, Clévio David Rodrigues. "Silencing ATXN2 expression using CRISPR/Cas9". Paper presented in 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  81. Nóbrega, Clévio David Rodrigues. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Paper presented in MJD International Research Conference, 2019.
  82. Nóbrega, Clévio David Rodrigues. "CYP46A1-Gene therapy alleviates Machado-Joseph disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  83. Nóbrega, Clévio David Rodrigues. "On the role of stress granules in autophagy". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  84. Nóbrega, Clévio David Rodrigues. "RNA-binding proteins: new molecular targets for Polyglutamine diseases?". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  85. Nóbrega, Clévio David Rodrigues. "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  86. Nóbrega, Clévio David Rodrigues. "Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2". Paper presented in Gordon Conference on Clocks in Model Organisms: Circadian Networks, Physiology and Health, 2019.
  87. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  88. Nóbrega, Clévio David Rodrigues. "Estudo do papel de uma proteína de ligação ao RNA na expressão de lamina e progerina". Paper presented in 5th MEEting of UAlg Medicine Students, 2019.
  89. Nóbrega, Clévio David Rodrigues. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Paper presented in 1st international symposium Secretome With]Out[ Borders, 2018.
  90. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 at the crossroads of metabolism and circadian rhythm". Paper presented in Chrononutrition: From Epidemiology to Molecular Mechanism Symposium, London, 2018.
  91. Nóbrega, Clévio David Rodrigues. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Paper presented in European Society of Gene and Cell Therapy congress, 2018.
  92. Kumar, Sajal; Zhong, Hua; Sharma, Ruby; Li, Yiyi; Song, Mingzhou. "RNA-binding proteins in Polyglutamine diseases: from pathogenesis to molecular therapy". Paper presented in 11th Forum of Neuroscience (FENS), 2018.
    10.1109/bibm.2018.8621502
  93. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 a novel regulator of circadian rhythm". Paper presented in EMBO|EMBL Symposium: Biological Oscillators: Design, Mechanism, Function, 2018.
  94. Nóbrega, Clévio David Rodrigues. "Estudo do papel da autofagia na dispersão dos grânulos de stress". Paper presented in 4th MEEting of UAlg Medicine Students, 2018.
  95. Nóbrega, Clévio David Rodrigues. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2017.
  96. Nóbrega, Clévio David Rodrigues. "TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease". Paper presented in 2nd International Ataxia Research Conference (IARC), 2017.
  97. Nóbrega, Clévio David Rodrigues. "Ibuprofen improves neuropathology and increases neural progenitors proliferation, synaptic function and neurite growth in Machado-Joseph disease". Paper presented in 2nd International Ataxia Research Conference (IARC), 2017.
  98. Nóbrega, Clévio David Rodrigues. "Evaluation of proinflammatory cytokines expression in cells infected with coxsakievirus". Paper presented in XXVIII Congresso Brasileiro de Virologia, 2017.
  99. Nóbrega, Clévio David Rodrigues. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Paper presented in XV Meeting of the Portuguese Society for Neurosciences, 2017.
  100. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2: a new player in central regulation of energy balance". Paper presented in EMBO Workshop – Neural control of metabolism and eating behaviour, 2016.
  101. Nóbrega, Clévio David Rodrigues. "Ataxin-2 in the hypothalamus: a novel regulator of energy balance and metabolism". Paper presented in XIII CNC Annual Meeting, 2015.
  102. Nóbrega, Clévio David Rodrigues. "Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in mouse models of Machado-Joseph disease". Paper presented in 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2015.
  103. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". Paper presented in 11th NPY-PYY-PP International Meeting, 2015.
  104. Nóbrega, Clévio David Rodrigues. "Impact of hypothalamic ataxin-2 on energy balance and metabolic profile". Paper presented in 9th World Congress of the International Brain Research Organization (IBRO, 2015.
  105. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging". Paper presented in The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, 2015.
  106. Nóbrega, Clévio David Rodrigues. "Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology of a mouse model of Machado-Joseph disease". Paper presented in International Society for Stem Cell Research (ISSCR) 2015 annual meeting, 2015.
  107. Nóbrega, Clévio David Rodrigues. "Gene editing strategies towards Machado Joseph disease". Paper presented in EMBO workshop: "Modern DNA concepts and tools for safe gene transfer and modification", 2015.
  108. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 regulates energy balance and metabolism". Paper presented in Keystone Symposia, Neural Control of Metabolic Physiology and Diseases, 2015.
  109. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging". Paper presented in XII CNC Anual Meeting, 2014.
  110. Nóbrega, Clévio David Rodrigues. "Cerebellar transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in a transgenic mouse model of Machado-Joseph disease". Paper presented in XII CNC Anual Meeting, 2014.
  111. Magda M Santana; Nóbrega, Clévio David Rodrigues ; Nobre, Rui Jorge; Miranda, Catarina; Sousa-Ferreira, Ligia; Simões, Ana Teresa; Duarte, Sónia; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Paper presented in Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014.
  112. Nóbrega, Clévio David Rodrigues. "Association between obesity and polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5, and OLFM4 genes among Portuguese children". Paper presented in 21st European Congress on Obesity (ECO2014), 2014.
  113. Nóbrega, Clévio David Rodrigues. "Translational inhibition in Machado-Joseph disease: Ataxin-2 as a new molecular target". Paper presented in 5th Ataxia Investigators Meeting (AIM), 2014.
  114. Nóbrega, Clévio David Rodrigues. "Modulation of catalytic activity and polyQ toxicity by phosphorylation in spinocerebellar ataxia type 3". Paper presented in 5th Ataxia Investigators Meeting (AIM), 2014.
  115. Nóbrega, Clévio David Rodrigues. "Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease". Paper presented in 5th Ataxia Investigators Meeting (AIM), 2014.
  116. Nóbrega, Clévio David Rodrigues. "Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease". Paper presented in 5th Ataxia Investigators Meeting (AIM), 2014.
  117. Nóbrega, Clévio David Rodrigues. "Transplantation of cerebellar neural stem cells alleviates neuropathology and motor impairments in Machado Joseph Disease". Paper presented in 5th Ataxia Investigators Meeting (AIM), 2014.
  118. Nóbrega, Clévio David Rodrigues. "Post-translational modifications and polyglutamine diseases: the effects of ataxin-3 phosphorylation". Paper presented in Champalimaud Neuroscience Programme Symposium, 2013.
  119. Nóbrega, Clévio David Rodrigues. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Paper presented in 13th Meeting of the Portuguese Society for Neuroscience (SPN), 2013.
  120. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y ameliorates the phenotype of a mouse model of human premature aging". Paper presented in 7th Progeria Research Foundation International Workshop – Hand in Hand: Basic and Clinical Science Working Together Toward the Cure, 2013.
  121. Nóbrega, Clévio David Rodrigues. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Paper presented in X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, 2012.
  122. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y is an autophagy inducer in hypothalamic neurons". Paper presented in IX Center for Neuroscience and Cell Biology (CNC) Annual Meetin, 2012.
  123. Nóbrega, Clévio David Rodrigues. "Associação do polimorfismo -13910C>T à obesidade abdominal em crianças portuguesas". Paper presented in 16º Congresso Português de Obesidade, 2012.
  124. Nóbrega, Clévio David Rodrigues. "Silencing of mutant ataxin-3 rescues motor deficits and neuopathology in Machado-Joseph disease transgenic mice". Paper presented in The 8th FENS Forum of Neuroscience, 2012.
  125. Marzocchi, N.; Severi, S.; Pieri, M.; Zona, C.; Cavalcanti, S.. "Beclin-1 mitigates motor and neuropathological déficits in lentiviral and transgenic mouse models of Machado-Joseph disease". Paper presented in The 8th FENS Forum of Neuroscience, 2012.
    10.2495/bio050221
  126. Nóbrega, Clévio David Rodrigues. "RNA interference rescues cerebellar abnormalities and ataxia in a lentiviral-based model of Machado-Joseph disease". Paper presented in The National Ataxia Foundation 55th annual membership meeting, 2012.
  127. Nóbrega, Clévio David Rodrigues. "Polymorphism rs9939609 in the FTO gene is associated with obesity among Portuguese children". Paper presented in 15ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2011.
  128. Kai, Kazuharu; Saya, Hideyuki; Hortobagyi, Gabriel N.; Ueno, Naoto T.. "Excitotoxicity in cerebellar granule cells transduced with mutant ataxin-3". Paper presented in Champalimaud Neuroscience Symposium, Champalimaud Foundation, 2011.
    10.1158/1538-7445.am10-2458
  129. Nóbrega, Clévio David Rodrigues. "RNA interference rescues motor and neurological deficits in Machado-Joseph disease rodent models". Paper presented in CAG triplet disorders Gordon Research Conference, 2011.
  130. Nóbrega, Clévio David Rodrigues. "Overexpression of the autophagic beclin-1 protein mitigates motor and neuropathological deficits in lentiviral and transgenic mouse models of Machado-Joseph disease". Paper presented in CAG triplet disorders Gordon Research Conference, 2011.
  131. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction". Paper presented in CAG triplet disorders Gordon Research Conference, 2011.
  132. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction". Paper presented in 40th annual meeting of the Society for Neurosciences, 2010.
  133. Nóbrega, Clévio David Rodrigues. "Lentiviral injection of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction: can beclin-1 overexpression improve the pathological phenotype?". Paper presented in 18th ESGCT Annual Congress, 2010.
  134. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mousecerebellum induces behavioral deficits". Paper presented in Harvard Medical School: Molecular Mechanism in Neurodegeneration: from molecule to cure, 2010.
  135. Nóbrega, Clévio David Rodrigues. "Inhibition of mutant ataxin¬3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease". Paper presented in 11th Meeting of the Portuguese Society for Neurosciences, 2009.
  136. Nóbrega, Clévio David Rodrigues. "Inhibition of calpains prevents translocation of mutant ataxin¬3 to the nucleus and reduces neurodegeneration in a lentiviral mouse model of Machado¬Joseph Disease". Paper presented in IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009.
  137. Nóbrega, Clévio David Rodrigues. "Inhibition of calpains in a lentiviral mouse model of Machado¬Joseph Disease". Paper presented in CONSERT labcourse, Advanced Couse Symposium and Pratical Training, 2008.
  138. Nóbrega, Clévio David Rodrigues. "A new therapeutic approach to AMD (degenerative macular age-related disease)". Paper presented in CONSERT labcourse, Advanced Couse Symposium and Pratical Training, 2008.
  139. Nóbrega, Clévio David Rodrigues. "A multilocus survey of nucleotide variation in Drosophila madeirensis, an endemic species to Madeira Island". Paper presented in XIX European Drosophila Research Conference, 2005.
Edited book
  1. Nóbrega, Clévio David Rodrigues, ed. Polyglutamine Disorders. Springer International Publishing. 2018.
    10.1007/978-3-319-71779-1
  2. Nóbrega, Clévio David Rodrigues ; Sandro Alves, ed. Gene Silencing and Editing Strategies for Neurodegenerative Diseases. Frontiers Media SA. 2018.
    10.3389/978-2-88945-551-5
  3. Nóbrega, Clévio David Rodrigues; Rodríguez-López, Raquel, ed. Molecular mechanisms underpinning the development of obesity. US: Springer. 2015.
    Published
Journal article
  1. Ferreira-Marques, Marisa; Carmo-Silva, Sara; Joana Filipa Costa Pereira; Mariana Botelho Rocha; Nóbrega, Clévio David Rodrigues ; López-Otín, Carlos; Pereira de Almeida, Luis Fernando Morgado; Aveleira, Célia; Cavadas, Claudia. Corresponding author: Cavadas, Claudia. "Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice". Geroscience (2025):
    Accepted
  2. Costa, Rafael G; Conceição, André; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "The polyglutamine protein ATXN2: from its molecular functions to its involvement in disease". Cell Death & Disease 15 6 (2024): http://dx.doi.org/10.1038/s41419-024-06812-5.
    Published • 10.1038/s41419-024-06812-5
  3. Nádia Silva; Ana Teresa Rajado; Filipa Esteves; David Brito; Joana Apolónio; Vânia Palma Roberto; Alexandra Binnie; et al. "Measuring healthy ageing: current and future tools". Biogerontology (2023): https://doi.org/10.1007/s10522-023-10041-2.
    10.1007/s10522-023-10041-2
  4. Tiago Moreira-Gomes; Clévio Nóbrega. "From the disruption of RNA metabolism to the targeting of RNA-binding proteins: The case of polyglutamine spinocerebellar ataxias". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.16010.
    10.1111/jnc.16010
  5. Moreira-Gomes, Tiago; Nóbrega, Clévio. "From the disruption of RNA metabolism to the targeting of RNA-binding proteins: The case of polyglutamine spinocerebellar ataxias". Journal of Neurochemistry (2023): http://dx.doi.org/10.1111/jnc.16010.
    10.1111/jnc.16010
  6. Brito, D. V. C.; Esteves, F.; Rajado, A. T.; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging 9 1 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    10.1038/s41514-023-00120-6
  7. Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; Araújo, Inês; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854. http://dx.doi.org/10.1016/j.mad.2023.111854.
    10.1016/j.mad.2023.111854
  8. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David V.C.; ALFA Score Consortium; Binnie, Alexandra; Araújo, Inês Maria; et al. Corresponding author: Pedro Castelo-Branco. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging 15 8 (2023): 3191-3217.
    Published • 10.18632/aging.204668
  9. Rodrigo Paulino; Clévio Nóbrega. "Autophagy in Spinocerebellar Ataxia Type 3: From Pathogenesis to Therapeutics". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24087405.
    10.3390/ijms24087405
  10. Elena Grao-Cruces; Carmen M. Claro-Cala; Sergio Montserrat-de la Paz; Clevio Nobrega. "Lipoprotein Metabolism, Protein Aggregation, and Alzheimer’s Disease: A Literature Review". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032944.
    10.3390/ijms24032944
  11. Carmo-Silva, Sara; Ferreira-Marques, Marisa; Nóbrega, Clévio; Botelho, Mariana; Costa, Daniela; Aveleira, Célia A; Pulst, Stefan M; Pereira de Almeida, Luís; Cavadas, Claudia. "Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes". Journal of Molecular Endocrinology 70 1 (2023): http://dx.doi.org/10.1530/jme-21-0272.
    10.1530/jme-21-0272
  12. Estevam, Bernardo; Matos, Carlos A; Nóbrega, Clévio; Bernardo Estevam; Carlos A Matos; Clévio Nóbrega. "PolyQ Database—an integrated database on polyglutamine diseases". Database 2023 (2023): http://dx.doi.org/10.1093/database/baad060.
    10.1093/database/baad060
  13. Adriana Marcelo; Carlos A. Matos; Clévio Nóbrega. "Autophagy is dysregulated in spinocerebellar ataxia type 2". Autophagy Reports (2022): https://doi.org/10.1080/27694127.2022.2065603.
    10.1080/27694127.2022.2065603
  14. Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain (2022): http://dx.doi.org/10.1093/brain/awac473.
    10.1093/brain/awac473
  15. Inês T. Afonso; Patrícia Lima; André Conceição; Carlos A. Matos; Clévio Nóbrega. "Mutant Ataxin-2 Expression in Aged Animals Aggravates Neuropathological Features Associated with Spinocerebellar Ataxia Type 2". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231911896.
    10.3390/ijms231911896
  16. Vasconcelos-Ferreira, Ana; Martins, Inês Morgado; Lobo, Diana; Pereira, Dina; Lopes, Miguel M.; Faro, Rosário; Lopes, Sara M.; et al. "ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease". Molecular Therapy 30 1 (2022): 370-387. http://dx.doi.org/10.1016/j.ymthe.2021.07.012.
    10.1016/j.ymthe.2021.07.012
  17. Carmo-Silva, Sara; Ferreira-Marques, M; Nóbrega, Clévio David Rodrigues ; Botelho M; Costa, D; Aveleira C; Pulst, Stefan; Almeida, Luís Pereira de; Cavadas, Claudia. "Ataxin-2 in the hypothalamus at the crossroads between metabolism & circadian rhythm". Journal of Molecular Endocrinology (2022):
    Published • 10.1530/JME-21-0272
  18. Carmo-Silva, Sara; Ferreira-Marques, Marisa; Nóbrega, Clévio David Rodrigues ; Botelho, Mariana; Costa, Daniela G.; Pulst, Stefan M; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Deciphering a new role for Ataxin-2 in the hypothalamus: linking metabolism and circadian rhythm regulation.". Molecular Endocrinology (2022):
    Under revision
  19. Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V. C.; Costa, Rafael G.; Rosa, Ana; Alves-Cruzeiro, João; et al. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death & Disease 12 12 (2021): http://dx.doi.org/10.1038/s41419-021-04404-1.
    10.1038/s41419-021-04404-1
  20. Vasconcelos-Ferreira, Ana; Carmo-Silva, Sara; Codêsso, José Miguel; Silva, Patrick; Martinez, Alberto Rolim Muro; França Jr, Marcondes Cavalcante; Nóbrega, Clévio; Pereira de Almeida, Luís. "The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease". Neuropathology and Applied Neurobiology 48 1 (2021): http://dx.doi.org/10.1111/nan.12763.
    10.1111/nan.12763
  21. Marcelo, Adriana; Koppenol, Rebekah; de Almeida, Luís Pereira; Matos, Carlos A.; Nóbrega, Clévio. "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?". Cell Death & Disease 12 6 (2021): http://dx.doi.org/10.1038/s41419-021-03873-8.
    10.1038/s41419-021-03873-8
  22. Afonso-Reis, Ricardo; Afonso, Inês T.; Nóbrega, Clévio. "Current Status of Gene Therapy Research in Polyglutamine Spinocerebellar Ataxias". International Journal of Molecular Sciences 22 8 (2021): 4249. http://dx.doi.org/10.3390/ijms22084249.
    10.3390/ijms22084249
  23. Nóbrega, Clévio David Rodrigues. "Mapping gene expression in social anxiety reveals the main brain structures involved in this disorder". Brain Behavioural Research 394 (2021):
    Published
  24. Nóbrega, Clévio David Rodrigues. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021):
    Published
  25. Nóbrega, Clévio; Conceição, André; Costa, Rafael G.; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; et al. "The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease". BMC Research Notes 13 1 (2020): http://dx.doi.org/10.1186/s13104-020-05053-x.
    10.1186/s13104-020-05053-x
  26. Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al. "Trehalose alleviates the phenotype of Machado–Joseph disease mouse models". Journal of Translational Medicine 18 1 (2020): http://dx.doi.org/10.1186/s12967-020-02302-2.
    10.1186/s12967-020-02302-2
  27. Nóbrega, Clévio David Rodrigues. "Lauroylated Histidine-Enriched S4 13-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells". Pharmaceutical Research 37 (2020):
    Published
  28. Catarina Nunes; Isa Mestre; Adriana Marcelo; Rebekah Koppenol; Carlos A Matos; Clévio Nóbrega. "MSGP: the first database of the protein components of the mammalian stress granules". Database (2019): https://doi.org/10.1093/database/baz031.
    10.1093/database/baz031
  29. Adriana Marcelo; Filipa Brito; Sara Carmo-Silva; Carlos A Matos; João Alves-Cruzeiro; Ana Vasconcelos-Ferreira; Rebekah Koppenol; et al. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models". Human Molecular Genetics (2019): https://doi.org/10.1093/hmg/ddy328.
    10.1093/hmg/ddy328
  30. Nóbrega, C.; Mendonça, L.; Marcelo, A.; Lamazière, A.; Tomé, S.; Despres, G.; Matos, C.A.; et al. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia". Acta Neuropathologica 138 5 (2019): 837-858. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067663327&partnerID=MN8TOARS.
    10.1007/s00401-019-02019-7
  31. Mendonça, L.S.; Nóbrega, C.; Tavino, S.; Brinkhaus, M.; Matos, C.; Tomé, S.; Moreira, R.; et al. "Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models". Human molecular genetics 28 22 (2019): 3691-3703. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077346304&partnerID=MN8TOARS.
    10.1093/hmg/ddz097
  32. Nóbrega, C.; Codêsso, J.M.; Mendonça, L.; Pereira De Almeida, L.. "RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3". Human Gene Therapy 30 7 (2019): 841-854. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069664080&partnerID=MN8TOARS.
    10.1089/hum.2018.157
  33. Matos, Carlos A.; de Almeida, Luís Pereira; Nóbrega, Clévio. "Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy". Journal of Neurochemistry 148 1 (2018): 8-28. http://dx.doi.org/10.1111/jnc.14541.
    10.1111/jnc.14541
  34. Nóbrega, Clévio; Alves, Sandro. "Editorial: Gene Silencing and Editing Strategies for Neurodegenerative Diseases". Frontiers in Neuroscience 12 (2018): http://dx.doi.org/10.3389/fnins.2018.00425.
    10.3389/fnins.2018.00425
  35. Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS.
    10.1016/j.ymthe.2018.07.007
  36. Mendonça, L.S.; Onofre, I.; Miranda, C.O.; Perfeito, R.; Nóbrega, C.; de Almeida, L.P.. "Stem Cell-Based Therapies for Polyglutamine Diseases". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041956170&partnerID=MN8TOARS.
    10.1007/978-3-319-71779-1_21
  37. Nóbrega, C.; Simões, A.T.; Duarte-Neves, J.; Duarte, S.; Vasconcelos-Ferreira, A.; Cunha-Santos, J.; Pereira, D.; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041952619&partnerID=MN8TOARS.
    10.1007/978-3-319-71779-1_18
  38. Matos, C.A.; Carmona, V.; Vijayakumar, U.-G.; Lopes, S.; Albuquerque, P.; Conceição, M.; Nobre, R.J.; Nóbrega, C.; de Almeida, L.P.. "Gene therapies for polyglutamine diseases". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041963917&partnerID=MN8TOARS.
    10.1007/978-3-319-71779-1_20
  39. Carmo-Silva, S.; Nobrega, C.; Pereira de Almeida, L.; Cavadas, C.. "Unraveling the Role of Ataxin-2 in Metabolism". Trends in Endocrinology and Metabolism 28 4 (2017): 309-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009726744&partnerID=MN8TOARS.
    10.1016/j.tem.2016.12.006
  40. Albuquerque, D.; Nóbrega, C.; Manco, L.; Padez, C.. "The contribution of genetics and environment to obesity". British Medical Bulletin 123 1 (2017): 159-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029678152&partnerID=MN8TOARS.
    10.1093/bmb/ldx022
  41. Matos, C.A.; de Almeida, L.P.; Nóbrega, C.. "Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the toxic fragment hypothesis". Current Pharmaceutical Design 23 5 (2017): 753-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017122161&partnerID=MN8TOARS.
    10.2174/1381612822666161227121912
  42. Alves-Cruzeiro, João M. Da Conceição; Mendonça, Liliana; Pereira de Almeida, Luís; Nóbrega, Clévio. "Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review". Frontiers in Neuroscience 10 (2016): http://dx.doi.org/10.3389/fnins.2016.00572.
    10.3389/fnins.2016.00572
  43. Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype". Biomaterials 82 (2016): 124-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956644943&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2015.12.021
  44. Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. "Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles". Data in Brief 6 (2016): 700-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956617357&partnerID=MN8TOARS.
    10.1016/j.dib.2016.01.017
  45. Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L.. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models". Journal of Cell Biology 212 4 (2016): 465-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS.
    10.1083/jcb.201506025
  46. Aveleira CA; Botelho M; Carmo-Silva S; Pascoal JF; Ferreira-Marques M; Nóbrega C; Cortes L; et al. "Neuropeptide Y stimulates autophagy in hypothalamic neurons.". (2015): http://europepmc.org/abstract/med/25775546.
    10.1073/pnas.1416609112
  47. Albuquerque D; Stice E; Rodríguez-López R; Manco L; Nóbrega C; Albuquerque, David; Stice, Eric; et al. "Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.". (2015): http://europepmc.org/abstract/med/25749980.
    10.1007/s00438-015-1015-9
  48. Nóbrega, C.; Carmo-Silva, S.; Albuquerque, D.; Vasconcelos-Ferreira, A.; Vijayakumar, U.-G.; Mendonça, L.; Hirai, H.; Pereira De Almeida, L.. "Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease". Brain 138 12 (2015): 3537-3554. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951031850&partnerID=MN8TOARS.
    10.1093/brain/awv298
  49. Albuquerque, David; Nóbrega, Clévio; Rodríguez-López, Raquel; Manco, Licínio. "Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children". Journal of Human Genetics 59 6 (2014): 307-313. http://dx.doi.org/10.1038/jhg.2014.23.
    10.1038/jhg.2014.23
  50. Albuquerque, David; Estévez, Manuela Núñez; Víbora, Pilar Beato; Giralt, Plácida Sánchez; Balsera, Aránzazu Margallo; Cortés, Pedro Gil; López, Mercedes Jiménez; et al. "Novel Variants in theMC4RandLEPRGenes among Severely Obese Children from the Iberian Population". Annals of Human Genetics 78 3 (2014): 195-207. http://dx.doi.org/10.1111/ahg.12058.
    Published • 10.1111/ahg.12058
  51. Mendonca, L. S.; Nobrega, C.; Hirai, H.; Kaspar, B. K.; Pereira de Almeida, L.. "Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice". Brain n 19 Dec (2014): 1-9.
    Published • 10.1093/brain/awu352
  52. Nobrega, Clevio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Deglon, Nicole; Pereira de Almeida, Luis. "RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of machado-joseph disease.". PloS one 9 8 (2014): e100086-e100086. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:25144231&KeyUID=MEDLINE:25144231.
    10.1371/journal.pone.0100086
  53. Albuquerque, David; Nóbrega, Clévio; Manco, Licínio. "The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children". Acta Paediatrica 102 4 (2013): e153-e157. http://dx.doi.org/10.1111/apa.12134.
    10.1111/apa.12134
  54. Nascimento-Ferreira, I.; Nobrega, C.; Vasconcelos-Ferreira, A.; Onofre, I.; Albuquerque, D; Aveleira, C.; Hirai, H.; Deglon, N.; Pereira de Almeida, L.. "Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease". Brain 136 7 (2013): 2173-2188.
    Published • 10.1093/brain/awt144
  55. Albuquerque, David; Nóbrega, Clévio; Manco, Licínio. "Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children". PLoS ONE 8 1 (2013): e54370-e54370.
    Published • 10.1371/journal.pone.0054370
  56. Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Hirai, Hirokazu; Déglon, Nicole; de Almeida, Luís Pereira. "Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice". PLoS ONE 8 1 (2013): e52396-e52396.
    Published • 10.1371/journal.pone.0052396
  57. Monteiro, António; Nóbrega, Clévio; Abrantes, Isabel; Gomes, Celeste. "Diagnosing Portuguese Students' Misconceptions about the Mineral Concept". International Journal of Science Education 12 (2012): 1-22.
    Published • 10.1080/09500693.2012.731617
  58. Costa, P. M.; Cardoso, A. L.; Nobrega, C.; Pereira de Almeida, L. F.; Bruce, J. N.; Canoll, P.; Pedroso de Lima, M. C.. "MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma". Human Molecular Genetics 22 5 (2012): 904-918.
    Published • 10.1093/hmg/dds496
  59. Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Conceição, Mariana; Déglon, Nicole; Almeida, Luís Pereira. "Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology". The Cerebellum . (2012): .-..
    Published • 10.1007/s12311-012-0432-0
  60. Albuquerque D; Nóbrega C; Samouda H; Manco L; Albuquerque, D; Nóbrega, Clévio David Rodrigues; Hanene Samouda; Manco, Licínio. "Assessment of obesity and abdominal obesity among Portuguese children.". Acta Medica Portuguesa 25 3 (2012): 169-173. http://europepmc.org/abstract/med/23069237.
    Published
  61. Albuquerque, D.; Nóbrega, C.; Samouda, H.; Manco, L.. "Assessment of obesity and abdominal obesity among Portuguese children,Avaliação da obesidade e obesidade abdominal em crianças Portuguesas". Acta Medica Portuguesa 25 3 (2012): 169-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866904803&partnerID=MN8TOARS.
  62. Sousa-Ferreira, Lígia; Garrido, Manuel; Nascimento-Ferreira, Isabel; Nobrega, Clévio; Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; et al. "Moderate Long-Term Modulation of Neuropeptide Y in Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats". PLoS ONE 6 7 (2011): 22333-22333.
    Published • 10.1371/journal.pone.0022333
  63. Khadem, M.; Camacho, R.; Nobrega, C.; Nóbrega, Clévio David Rodrigues; Mahnaz Khadem; Roberto Camacho. "Studies of the species barrier between Drosophila subobscura and D-madeirensis V: the importance of sex-linked inversion in preserving species identity". Journal of Evolutionary Biology 24 6 (2011): 1263-1273. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000290313500011&KeyUID=WOS:000290313500011.
    Published • 10.1111/j.1420-9101.2011.02263.x
  64. Alves, S.; Nascimento-Ferreira, I.; Dufour, N.; Hassig, R.; Auregan, G.; Nobrega, C.; Brouillet, E.; et al. "Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?". Human Molecular Genetics 19 12 (2010): 2380-2394.
    Published • 10.1093/hmg/ddq111
  65. Nobrega, C.; Khadem, M; Aguade, M.; Segarra, C. "Genetic Exchange versus Genetic Differentiation in a Medium-Sized Inversion of Drosophila: The A2/Ast Arrangements of Drosophila subobscura". Molecular Biology and Evolution 25 8 (2008): 1534-1543.
    Published • 10.1093/molbev/msn100
Online resource
  1. Estevam, Bernardo; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A. A Database for Polyglutamine Diseases. 2022. https://polyq.pt/.
Thesis / Dissertation
  1. Nóbrega, Clévio David Rodrigues. "A multilocus comparative study of nucleotide variation in Drosophila madeirensis and the close relative D. subobscura: insights into the speciation process of D. madeirensis". PhD, 2007. http://hdl.handle.net/10400.13/1429.
Website
  1. Nóbrega, Clévio David Rodrigues. Mammalian stress granules proteome. 2019. https://msgp.pt/.

Intellectual property

Patent
  1. Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues. 2023. "Compounds and composition for DNA protection".
  2. Nóbrega, Clévio David Rodrigues ; Koppenol, Rebekah; Conceição, André; Marcelo, Adriana. 2022. "ISOLATED OR ARTIFICIAL NUCLEOTIDES FOR USE IN NEURODEGENERATIVE DISEASES".
    Pending
  3. Nóbrega, Clévio David Rodrigues ; Koppenol, Rebekah; Marcelo, Adriana; Conceição, André. 2022. "Isolated or artificial nucleotide sequences for use in neurodegenerative diseases".
    Pending
  4. Nóbrega, Clévio David Rodrigues. 2018. "Expression vector for cholesterol 24-hydrolase in therapy of polyglutamine repeat spinocerebellar ataxias".
    Granted/Issued
  5. Nóbrega, Clévio David Rodrigues. 2014. "Neuropeptide Y overexpression for use in the treatment of premature aging".
    Granted/Issued

Other

Other output
  1. Polyglutamine disorders preface. 2018. Nóbrega, Clévio; Almeida, Luís Pereira de. http://hdl.handle.net/10400.1/11962.
    10.1007/978-3-319-71779-1
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - Current Assessing the Impact of nanoparticle-encapsulated induced mesenchymal stem cells secretome in a 3D in vitro model of Parkinson’s disease
Co-supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2022 - Current Modulation of a RBP as potential therapeutic strategy for SCA2
Supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2022 - Current Disease spreading in spinocerebellar ataxia type 2: from pathogenic mechanisms to targeted therapeutics
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2021 - Current Brain-targeted lipid-based nanovesicles to deliver brain plasticity modulators – a strategy to enhance brain cell-replacement therapeutics in Machado-Joseph disease
Co-supervisor
 Ciências Farmacêuticas (PhD)
Universidade de Coimbra, Portugal
2021 - Current Targeting transcriptional dysregulation in Machado-Joseph disease: silencing Trmt2a as a novel therapeutic target
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2020 - Current Unraveling the role of RNA-binding proteins in Polyglutamine Diseases: from pathogenesis to therapeutics
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2020 - Current Connecting mutant Ataxin-2 and synaptic disfunction: are stress granules the link?
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2019 - Current Targeting the ATXN2 gene with the CRISPR-Cas9 system as a therapeutic strategy for spinocerebellar ataxia type 2
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2013 - Current Investigating transcriptional modifications of the autophagy pathway in Machado-Joseph disease
Co-supervisor
 Ciências Farmacêuticas (PhD)
Universidade de Coimbra, Portugal
2021 - 2022 Modelling ageing in vitro using stem cells-derived cells
Co-supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2021 - 2022 PolyQbase – The integrated database for polyglutamine disease
Supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2020 - 2022 Protein synthesis and ageing: is translation rate a major regulator?
Supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2017 - 2022 Stress granules in Polyglutamine diseases: new targets for therapeutic intervention?
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2020 - 2021 Spreading of mutant ataxin-2 through extracellular vesicles
Supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2019 - 2021 On the role of brain ataxin-2 in whole-body aging
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2019 - 2021 Role of neuronal cholesterol in peripheric tissues
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2019 - 2020 A neuroendocrine strategy to delay aging
Co-supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2019 - 2020 Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon
Co-supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2019 - 2020 Ciliary recruitment of Dynein-2 motor and its role in C. elegans sensory functions, with emphasis in male mating behavior
Co-supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2019 - 2020 Terapia génica: Sistemas de Entrega, Mecanismos Moleculares e Abordagens Terapêuticas Aprovadas
Supervisor
 Ciências Farmacêuticas (Master)
Universidade do Algarve, Portugal
2019 - 2020 Controlling the effect of injection in the hypothalamus of diet-induced obese mice
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2019 - 2020 On the role of an RNA-binding protein in a transgenic mouse model of Polyglutamine diseases
Supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2019 - 2020 The impact of aging in mutant ataxin-2 induced neurodegeneration
Supervisor
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2018 - 2020 Targeting hypothalamus: diet impact, bacterial composition and memory impair
Co-supervisor
 Biologia Molecular e Microbiana (Master)
Universidade do Algarve, Portugal
2018 - 2020 Silencing of CYPX gene in the hypothalamus and its impact on whole-body metabolism
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2018 - 2019 Insights into the role of G3BP1 on Polyglutamine diseases
Supervisor
 Biologia Molecular e Microbiana (Master)
Universidade do Algarve, Portugal
2017 - 2019 On the role of stress granules in autophagy
Supervisor
 Neurociências (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018 Estudo da via da autofagia no contexto da ataxia espinocerebelosa do tipo 2
Supervisor
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - 2018 A catalogue of mammalian stress granules components: implications for neurodegeneration
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2015 - 2016 PERK inhibition role in Spinocerebellar ataxias
Supervisor
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra, Portugal
2015 - 2016 INSIGHTS INTO THE ROLE OF STRESS GRANULES IN SPINOCEREBELLAR ATAXIAS
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2015 - 2016 Development of a striatal lentiviral mouse model of Spinocerebellar ataxia type 2
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2014 - 2015 Pharmacological modulation of mutant ataxin-3 translation and it potential therapeutic effect in Machado Joseph disease
Supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra, Portugal
2011 - 2015 Study of genetic variants associated with obesity in Portuguese children
Co-supervisor
 Doutoramento em Antropologia, na especialidade de Antropologia Biológica (PhD)
Universidade de Coimbra, Portugal
2011 - 2012 Pharmacological activation of autophagy in Machado-Joseph disease
Co-supervisor
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020 Silencing of CYPX gene in the hypothalamus and its impact on whole-body metabolism
Supervisor
 Adriana Arrulo (Master)
Universidade do Algarve, Portugal
2020 Targeting hypothalamus: diet impact, bacterial composition and memory impair
Supervisor
 Bruno Várzea (Master)
Universidade do Algarve, Portugal
2020 InCited2 secrete cardiogenic molecules
(Thesis) Main arguer
 João André Lopes (Master)
Universidade do Algarve, Portugal
2020 Terapia génica: Sistemas de Entrega, Mecanismos Moleculares e Abordagens Terapêuticas Aprovadas
Supervisor
 Carolina Biscaia (Master)
Universidade do Algarve, Portugal
2020 A NEUROENDOCRINE STRATEGY TO DELAY AGING
Supervisor
 Hélio Conceição (Master)
Universidade do Algarve, Portugal
2020 Estudo do papel de uma proteína ligante de RNA num modelo animal das doenças de poliglutaminas
Supervisor
 Joana Pinto (Master)
Universidade do Algarve, Portugal
2020 The impact of aging in mutant ataxin-2 induced neurodegeneration
Supervisor
 Patrícia Lima (Master)
Universidade do Algarve, Portugal
2020 Functional studies on ZEB transcription factors in glioblastoma
President of the jury
 Nuno Ramalho (Master)
Universidade do Algarve, Portugal
2020 Controlling the effect of injection in the hypothalamus of diet-induced obese mice
Supervisor
 Renata Sandres Souza Araújo (Master)
Universidade do Algarve, Portugal
2019 On the persistence of therapy: the potential of miRNA modulation in Alzheimer disease
(Thesis) Main arguer
 Ana Teresa de Barros Viegas (PhD)
Universidade de Coimbra, Portugal
2019 Insights into the role of G3BP1 on Polyglutamine diseases
Supervisor
 Diogo Teixeira (Master)
Universidade do Algarve, Portugal
2019 Estudo comparativo e diferencial dos genes Mob: os interactuantes proteicos e expressão transcricional em contextos de normalidade e tumorais
(Thesis) Main arguer
 Ricardo Resende (Master)
Universidade do Algarve, Portugal
2019 Patient-specific iPSC-derived NESC for Machado-Joseph disease treatment
(Thesis) Main arguer
 Vanessa Alexandra Castanheira (Master)
Universidade de Coimbra, Portugal
2019 Toward the isolation of exosomes by flow cytometry.
(Thesis) Main arguer
 André Mozes (Master)
Universidade do Algarve, Portugal
2019 Study of the TRIB2 protein network.
(Thesis) Main arguer
 Catarina Raposo (Master)
Universidade do Algarve, Portugal
2019 On the role of stress granules in autophagy.
Supervisor
 Rebekah Koppenol (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 Understanding the potential of PDMAEMA-based vectors for gene therapy of the retina.
(Thesis) Main arguer
 Diogo Miguel Barros Bitoque (PhD)
Universidade Nova de Lisboa, Portugal
2018 Identification of S-Nitrosylated proteins in injury-induced neurogenesis.
Thesis Member
 Ana Sofia Lourenço (PhD)
Universidade do Algarve, Portugal
2018 Estudo da via da autofagia no contexto da ataxia espinocerebelosa do tipo 2
Supervisor
 Marta Santos (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 Role of microRNA deregulation in the pathogenesis of Machado-Joseph disease.
(Thesis) Main arguer
 Udaya Geetha Vijayakumar (PhD)
Universidade de Coimbra, Portugal
2017 Unravelling the role of ataxin-2 in the hypothalamus: a new player in metabolism.
(Thesis) Arguer
 Sara Matias Carmo Silva (PhD)
Universidade de Coimbra, Portugal
2017 Abordagem terapêutica na doença de Alzheimer?
(Thesis) Main arguer
 Bárbara Martins Sousa (Master)
Universidade do Algarve, Portugal
2016 Neuropeptide Y gene transfer for neuroprotection in Machado-Joseph Disease
Thesis Member
 Joana Filipa Duarte das Neves (PhD)
Universidade de Coimbra, Portugal
2016 Clarifying the mechanism of action of trehalose on alleviating MJD.
(Thesis) Main arguer
 Allyson Trevino Garcia (Master)
Universidade de Coimbra, Portugal
2016 Development of a striatal lentiviral mouse model of Spinocerebellar ataxia type.
Supervisor
 João Alves-Cruzeiro (Master)
Hospitais da Universidade de Coimbra, Portugal
2016 Insights into the role of stress granules in spinocerebellar ataxias.
Supervisor
 Sandra Tomé (Master)
Universidade de Coimbra, Portugal
2016 Strategies to reverse celular senescence and enhance progerin clearance in Hutchinson-Gilford progeria syndrome.
(Thesis) Main arguer
 Ana Sofia Leal (Master)
Universidade de Coimbra, Portugal
2016 Characterization of mitochondrial function and dynamics in models of Machado-Joseph disease.
(Thesis) Main arguer
 Filipa Almeida (Master)
Universidade de Coimbra, Portugal
2015 Optimization of a viral culture system to evaluate antiviral activity
(Thesis) Main arguer
 Nânci Lúcia Ferreira (Master)
Universidade de Coimbra, Portugal
2013 Caracterização do perfil genómico do carcinoma pulmonar
(Thesis) Main arguer
 Sérgio Portovedo (Master)
Universidade de Coimbra, Portugal
2012 Pharmacological activation of autophagy in Machado Joseph disease
Supervisor
 Ana Cristina Vasconcelos Ferreira (Master)
Universidade de Coimbra, Portugal
2012 Immobilization of Metalloproteins for Biotechnogical Applications
(Thesis) Main arguer
 Tânia Isabel Rodrigues Genebra (Master)
Universidade de Coimbra, Portugal

Conference scientific committee

Conference name Conference host
2019/06 - Current XVI Meeting of the Portuguese Society for Neuroscience Lisboa
Distinctions

Award

2018 Janssen Innovation Award (2nd edition)
2017 Young Scientist Lectureship Award
2016 Human Genetics Portuguese Society Award