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Marisa Isabel Lopes de Sousa. Completed her Medical Doctor degree in 2019 by Universidade do Algarve, her PhD in Biochemistry - Molecular Genetics in 2012 by Universidade de Lisboa Faculdade de Ciências, and her BSc in Pathological Anatomy in 2005 by Instituto Politécnico de Lisboa. She is a medical doctor (general internship) at Hospital de Vila Franca de Xira. Published 13 articles in journals. Has received 5 awards and/or honors. Has more than 10 oral communications in scientific conferences, meetings and seminars (by invitation) and more than 15 posters in scientific conferences and meetings. Participation in the organization of six scientific events/ conferences (logistics) and as lecturer/lab instructor at three international Scientific Workshops. Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine, namely on Physiology, Human Genetics and Clinical Medicine. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: biochemistry; electrophysiology; ion channels; epithelial transport; cystic fibrosis diagnosis, prognosis and treatment; CFTR; chronic pain; pain killers; public health.
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Identification

Personal identification

Full name
Marisa Isabel Lopes de Sousa

Citation names

  • Sousa, Marisa

Author identifiers

Ciência ID
BA1E-280D-62D3
ORCID iD
0000-0003-2305-4813

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Physiology
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Clinical Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2)
Spanish; Castilian Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
French Elementary (A2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Education
Degree Classification
2019
Concluded
 Medicina (Mestrado integrado)
Universidade do Algarve, Portugal
 17
2012
Concluded
 Biochemistry - Molecular Genetics (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Correction of the ion transport defect in Cystic fibrosis by small molecules" (THESIS/DISSERTATION)
 Approved with Distinction and Honors (summa cum la
2005
Concluded
 Anatomia Patológica, Citológica e Tanatológica (Licenciatura)
Instituto Politécnico de Lisboa, Portugal
"Satisfação Profissional dos Técnicos de Anatomia Patológica, Citológica e Tanatológica" (THESIS/DISSERTATION)
 16
2004
Concluded
 Anatomia Patológica, Citológica e Tanatológica (Bacharelato)
Instituto Politécnico de Lisboa, Portugal
"Controlo de Qualidade dos reagentes e soluções da Coloração de Papanicolaou" (THESIS/DISSERTATION)
 16
Affiliation

Other Careers

Category
Host institution 		Employer
2021/10/12 - Current Interno (Médica) Administração Regional de Saúde de Lisboa e Vale do Tejo IP, Portugal
Unidade de Saúde Familiar Samora Correia, Portugal
2020/01/01 - 2021/10/11 Interno (Médica) Hospital de Vila Franca de Xira, Portugal

Others

Category
Host institution 		Employer
2013/03/01 - 2015/08/31 Post-Doc Researcher Project: Identification of novel analgesics targeting ion channels in dorsal root ganglion neurons: implications for the management of painful diabetic neuropathy, (FCT fellowship: Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2012/08/01 - 2012/10/30 Post-Doc fellow Project: "Characterization of ER-quality control for the F508del-CFTR protein: potential therapeutic targets for cystic fibrosis", FCT Ref: PTDC/SAU-GMG/122299/2010 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2008/01/01 - 2012/07/20 PhD Student - "Correction of the ion transport in Cystic Fibrosis by small molecules" Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade Estadual de Campinas Faculdade de Ciencias Medicas, Brazil
(...)
2005/10/03 - 2007/12/31 Junior Student; Trainee by the Institute of Job and Professional Formation. Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2006/01/05 - 2006/07/03 Junior Student Universität Regensburg, Germany
Projects

Grant

Designation Funders
2013 - 2015 Metabolism and brain neural activity.
PrimeXS-0000226
Post-doc
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Concluded
2012 - 2012 Characterization of ER-quality control for the F508del-CFTR protein: potential therapeutic targets for cystic fibrosis
FCT: PTDC/SAU-GMG/122299/2010
Post-doc Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2011 Diagnosis, Prognosis and Treatment of Cystic Fibrosis
FCT: PIC/IC/83103/2007
Other
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2011 TargetScreen2 Novel Post-Genomics Cell-based Screens for Drug Targeting in Membrane Protein Disorders
EU-FP6-LSH-2005-07-1.2.5-3-037
Other
Universidade de Lisboa Faculdade de Ciências, Portugal
Concluded
2007 - 2010 A novel insight into CFTR Phosphorylation: implications for its processing, trafficking and function
FCT: PTDC/BIA-BCM/67058/2006
Other
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Journal article
  1. Sousa, Marisa. "Cortical deafness of following bilateral temporal lobe stroke.". Journal of Stroke and Cerebrovascular Diseases (2020): https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104827.
    10.1016/j.jstrokecerebrovasdis.2020.104827
  2. Sousa, Marisa. "Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR.". Pharmacology research & perspectives (2015): https://europepmc.org/articles/PMC4492728.
    10.1002/prp2.152
  3. Sousa, Marisa. "Comparative ex vivo, in vitro and in silico analyses of a CFTR splicing mutation: Importance of functional studies to establish disease liability of mutations.". Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2015): https://doi.org/10.1016/j.jcf.2015.02.002.
    10.1016/j.jcf.2015.02.002
  4. Sousa, Marisa. "Appearance of de novo dysplastic spitzoid compound naevus in an adalimumab-treated psoriatic patient: case report and review of the possible causal relationship with TNF-a blockers.". The Australasian journal of dermatology (2014): https://doi.org/10.1111/ajd.12170.
    10.1111/ajd.12170
  5. Servidoni, M.F.; Sousa, M.; Vinagre, A.M.; Cardoso, S.R.; Ribeiro, M.A.; Meirelles, L.R.; de Carvalho, R.B.; et al. "Rectal forceps biopsy procedure in cystic fibrosis: Technical aspects and patients perspective for clinical trials feasibility". BMC Gastroenterology 13 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84877844941&partnerID=MN8TOARS.
    10.1186/1471-230X-13-91
  6. Moniz, S.; Sousa, M.; Moraes, B.J.; Mendes, A.I.; Palma, M.; Barreto, C.; Fragata, J.I.; Amaral, M.D.; Matos, P.. "HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent cystic fibrosis mutant F508del-CFTR". ACS Chemical Biology 8 2 (2013): 432-442. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874094442&partnerID=MN8TOARS.
    10.1021/cb300484r
  7. Tian, Y.; Schreiber, R.; Wanitchakool, P.; Kongsuphol, P.; Sousa, M.; Uliyakina, I.; Palma, M.; et al. "Control of TMEM16A by INO-4995 and other inositolphosphates". British Journal of Pharmacology 168 1 (2013): 253-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872858136&partnerID=MN8TOARS.
    10.1111/j.1476-5381.2012.02193.x
  8. Almaça, J.; Faria, D.; Sousa, M.; Uliyakina, I.; Conrad, C.; Sirianant, L.; Clarke, L.A.; et al. "High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets". Cell 154 6 (2013): 1390-1400. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884266668&partnerID=MN8TOARS.
    10.1016/j.cell.2013.08.045
  9. Farinha, C.M.; King-Underwood, J.; Sousa, M.; Correia, A.R.; Henriques, B.J.; Roxo-Rosa, M.; Da Paula, A.C.; et al. "Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction". Chemistry and Biology 20 7 (2013): 943-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880894290&partnerID=MN8TOARS.
    10.1016/j.chembiol.2013.06.004
  10. Sousa, M.; Servidoni, M.F.; Vinagre, A.M.; Ramalho, A.S.; Bonadia, L.C.; Felício, V.; Ribeiro, M.A.; et al. "Measurements of CFTR-Mediated Cl- Secretion in Human Rectal Biopsies Constitute a Robust Biomarker for Cystic Fibrosis Diagnosis and Prognosis". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867641604&partnerID=MN8TOARS.
    10.1371/journal.pone.0047708
  11. Luz, S.; Kongsupho, P.; Mendes, A.I.; Romeiras, F.; Sousa, M.; Schreiber, R.; Matos, P.; et al. "Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase a-induced activity". Molecular and Cellular Biology 31 22 (2011): 4392-4404. http://www.scopus.com/inward/record.url?eid=2-s2.0-83255187903&partnerID=MN8TOARS.
    10.1128/MCB.05517-11
  12. Da Paula, A.C.; Sousa, M.; Xu, Z.; Dawson, E.S.; Boyd, A.C.; Sheppard, D.N.; Amaral, M.D.. "Folding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteins". Journal of Biological Chemistry 285 35 (2010): 27033-27044. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956240070&partnerID=MN8TOARS.
    10.1074/jbc.M110.120352
  13. Sousa, M.; Ousingsawat, J.; Seitz, R.; Puntheeranurak, S.; Regalado, A.; Schmidt, A.; Grego, T.; et al. "An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis". Molecular Pharmacology 71 1 (2007): 366-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845908478&partnerID=MN8TOARS.
    10.1124/mol.106.025262
Activities

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2014/08/20 Avaliação das correntes contínua pulsada e contínua constante pelo método de iontoforese por pilocarpina em indivíduos com e sem Fibrose Cística
(Thesis) Main arguer
 Carla Gomez (Master)
Universidade Estadual de Campinas, Brazil

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014 - 2014 Lab Instructor and Lecturer at: “Brazilian-Canadian Workshop on Electrophysiology and Diagnosis in Cystic Fibrosis. Diagnosing Cystic Fibrosis in Neonates and Adults: Where do we draw the line?”. CIPED- Faculty of Medical Sciences, UNICAMP, Campinas, Brazil. Workshop on Electrophysiology Universidade Estadual de Campinas Faculdade de Ciencias Medicas, Brazil
2011 - 2011 Lab Instructor at the Department of Chemistry and Biochemistry, FCUL, Lisbon, Portugal (2011): Pilot PhD program: "Molecular and Cellular Biology of the Epithelium in Health and Disease - Workshop 02: Epithelial Cell Diferentiation, Cilia and Physiology” Workshop Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2008 Lab Instructor at the Department of Chemistry and Biochemistry, FCUL, Lisbon, Portugal (2008): International "Workshop on Epithelial Cells From Lung: Production, Cultivation and Characterization" Workshop Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2007 Lab Instructor at the Department of Chemistry and Biochemistry, FCUL, Lisbon, Portugal (2007): International "Workshop on Epithelial Cells & Tissues: Production, Cultivation and Characterization" Workshop Universidade de Lisboa Faculdade de Ciências, Portugal
Distinctions

Award

2013 Basic Research 2013 (with the publication: Almaça J, Faria D, Sousa M, et al. High-Content siRNA Screen Reveals Global ENaC Regulators and Potential Cystic Fibrosis Therapy Targets. 2013, Cell 154(6):1390-1400.)
Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal

Other distinction

2014 3-year Post-Doc Fellow: SFRH/BPD/97373/2013
Fundação para a Ciência e a Tecnologia, Portugal
2014 Short-term Travel Grant (Univ. Nottingham, UK)
Guarantors Of Brain, United Kingdom
2010 Short training fellowship (Nr 114842).
Fundação Calouste Gulbenkian, Portugal
2008 4-year PhD Fellowship: SFRH/BD/35936/2007.
Fundação para a Ciência e a Tecnologia, Portugal