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Débora Alexandra Reste Ferreira obtained her Bachelor's Degree in 2016/07 and her Master degree in 2018/10 both in Biochemistry at the University of Beira Interior. She developed her MSc research project in the field of Neurosciences under the supervision of Prof. Doctor Graça Baltazar at the CICS- University of Beira Interior. This project aimed at disclosing the role of the STEP in the control of neuroinflammation. Then, she became a Research Fellow in 2019/02- 2020/12, under a Centro 2020 Project entitled Interdisciplinary Challenges in Neurodegeneration (CENTRO-01-0145-FEDER-000013), ICON-BIM-04C, in the field of Neuroimmunology, under the supervision of Prof. Doctor Fernando A. Arosa and Prof. Doctor Elsa M. Cardoso, where her objective is to identify biomarkers through the phenotypic and functional study of immunological cells of the elderly and with neurodegenerative diseases population of Beira Interior (EBIcohort). She collaborated with the different researchers of the multidisciplinary team and also demonstrated broad autonomy for the analysis of scientific data. Then, she applied for a Doctoral Incentive Fellowship (BID/ICI-FCS/CICS/Santander Universidades-UBI/2020), which was awarded to her, based in neuroimmune crosstalk. In 2021/07- 2022/02, she became a Research Fellow in C4 - Cloud Computing Competence Centre (C4-UBI), C4_WP3.4_M1, under the supervision of Prof. Doctor Noel Lopes and Prof. Doctor Elsa M.Cardoso, to develop machine learning algorithms to detect disease risk factors, namely methods supervised and unsupervised for identification of cell populations and correlate with cognitive status. In 2022/09 she became a Biostatistician in Association for Innovation and Biomedical Research on Light and Image (AIBILI - Coimbra) in Diabetic Retinopathy Research Group. She collaborated with the multidisciplinary team (ophthalmologists, orthoptists, clinical team, project managers, engineers, data managers and other team members) and also demonstrated broad autonomy for the analysis of scientific data. Throughout the performance, she gained experience in applying concepts and methodologies in the planning of laboratory and clinical studies, as well as in the collection and statistical analysis of data from these studies; to delve into data analysis or use machine learning using a programming language (R, Python and Stata). Considering lab experience, she was autonomous in multidisciplinary skills: primary rat cell culture, immunocytochemistry, fluorescence microscopy, protein extraction and quantification, Western blot analysis, RNA extraction, cDNA synthesis, conventional PCR, real-time PCR, relative quantity and normalized expression, flow cytometry, isolation of peripheral blood mononuclear cells, magnetic beads cell isolation, ELISA assays, and immunoprecipitation. Considering Biostatistician experience, she are responsible for the creation, review, maintenance and oversight off contracted statistical output and activities in diabetic retinopathy group. Published 7 articles in journals.
Identification

Personal identification

Full name
Débora Alexandra Reste Ferreira

Citation names

  • Reste-Ferreira, Débora

Author identifiers

Ciência ID
B41C-6042-6D4D
ORCID iD
0000-0002-8769-1355

Email addresses

  • deboraferreira@fcsaude.ubi.pt (Professional)
  • resteferreira@ubi.pt (Professional)
  • daferreira@aibili.pt (Professional)
  • debi.ferreira@hotmail.com (Personal)

Addresses

  • Avenida Infante D. Henrique, 6201-506, Covilhã, Covilhã, Portugal (Professional)
  • AIBILI Edifício Prof. Doutor José Cunha-Vaz Azinhaga Sta. Comba, Celas, 3000-548, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2020/09 - 2022/07
Concluded
Biomedicina/Biomedicine (Pós-Graduação)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Approved (100%)
2021/10 - 2022/01
Concluded
Course: Machine Learning using Python (Outros)
Universidade da Beira Interior Departamento de Informática, Portugal
Approved
2021/11/15 - 2021/11/17
Concluded
Hands-on training course: Introduction to Machine Learning using R (Outros)
Instituto Gulbenkian de Ciência, Portugal
Approved (100%)
2021/03 - 2021/06
Concluded
PhD Advanced Course in Common Mechanisms in Neurodegeneration (Outros)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
15 em 20 valores
2021/02 - 2021/06
Concluded
PhD Advanced Course in Fundamental and Applied Immunology (Outros)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
18 em 20 valores
2020/10/19 - 2020/10/23
Concluded
PhD Advanced Course Stem Cell Technologies (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Fundação Champalimaud, Portugal
Approved (100%)
2020/07/08 - 2020/07/08
Concluded
Online Course "Introduction to Data Management Plans" - Ready for Biodata Management (Outros)
BioData.pt, Portugal
Approved (100%)
2016/09 - 2018/10
Concluded
Bioquímica/Biochemistry (Mestrado)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
"MSc thesis directed to Neuroscience area Role of STEP, a central nervous system specific phosphatase, in neuroinflammation 19 values" (THESIS/DISSERTATION)
16 em 20 valores
2017/07/11 - 2017/07/14
Concluded
Formação Jovens Investigadores (Outros)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Approved (100%)
2013/09 - 2016/06
Concluded
Bioquímica/Biochemistry (Licenciatura)
Universidade da Beira Interior Faculdade de Ciências, Portugal
" Final project direct to Cardiovascular Endocrinology Testosterone effect in the development of gestational hypertension" (THESIS/DISSERTATION)
13 em 20 valores
Affiliation

Others

Category
Host institution
Employer
2022/09 - Current Biostatistician in Diabetic Retinopathy Research Group Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal
2021/07 - 2022/08 Research fellow (C4_WP3.4_M1) in Centro de Competências em Cloud Computing, Portugal Universidade da Beira Interior - UBImedical, Portugal
2021/01/05 - 2021/06/04 Doctoral Incentive Fellowship (BID/ICI-FCS/CICS/Santander Universidades-UBI/2020) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/02/15 - 2020/12/31 Research Fellow (ICON-BIM-04C) in Neurologic and Neurovascular Disorders Group, Health Sciences Research Centre of University of Beira Interior , Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2021/07 - 2022/08 Machine Learning Algorithms to detect risk factors
C4_WP3.4_M1
Research Fellow
Universidade da Beira Interior - UBImedical, Portugal
Ongoing
2021/01 - 2021/06 Development of a human in vitro model to investigate CD8+ T cell responses to neuronal antigens presented by autologous dendritic cells
Bolsas de incentivo a doutoramento UBI-SANTANDER TOTTA 2020
Bolsa Santander Portugal
2019/02 - 2020/12 Interdisciplinary Challenges On Neurodegeneration (ICON) CENTRO-01-0145-FEDER-000013
ICON-BIM-04C
Research Fellow
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded

Other

Designation Funders
2020 - 2021 C4 - Centro de Competências em Cloud Computing
CENTRO-01-0145-FEDER- 000019
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
Outputs

Publications

Conference poster
  1. Esgalhado, AJ; Reste-Ferreira, Débora; Cardoso, Elsa Maria (3D1D-5BC2-1E48); Arosa, FA. "CD45RA, CD8ß, and IFN¿ represent a novel Immune signature of Human Cognitive Function". Paper presented in XVII Congress of the Iberian Society of Cytometry - SIC 2021, 2021.
  2. Ferreira, Débora; Esgalhado, AJ; Cardoso, Elsa Maria; Arosa, FA. "Identification of two novel CD8ß soluble isoforms in human peripheral blood lymphocytes". Paper presented in XV ANNUAL CICS-UBI SYMPOSIUM 2020, 2020.
  3. Esgalhado, AJ; Albino, S; Ferreira, Débora; Sousa, Adriana; Amaral, A; Martinho, A; Verde, I; et al. "Imbalances in T cell populations between volunteers of the EBICOHORT differing in their cognitive status". Paper presented in III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer, 2019.
  4. Ferreira, Débora; Esgalhado, AJ; Albino, S; Sousa, A.; Amaral, A; Martinho, A; Verde, I; et al. "Preliminary results of the characterization of the HLA genotype and Cytomegalovirus status in volunteers of the EBICOHORT". Paper presented in XIV Annual CICS-UBI Symposium. Covilhã, 2019.
    10.13031/aim.20162460290
  5. Soares, S.; Esgalhado, AJ; Ferreira, Débora; Amaral, A; Oliveira, Nádia; Afonso, M; Verde, I; et al. "Consumption of medicines in elderly volunteers of the EBICOHORT". Paper presented in XIV Annual CICS-UBI Symposium. Covilhã, 2019.
Journal article
  1. Santos, Ana Rita; Almeida, Ana Catarina; Rocha, Ana Cláudia; Reste-Ferreira, Débora; Marques, Inês Pereira; Cunha-Vaz Martinho, António; Mendes, Luís; et al. "Central and Peripheral Involvement of the Retina in the Initial Stages of Diabetic Retinopathy". Retina (2023): http://dx.doi.org/10.1097/iae.0000000000004021.
    10.1097/iae.0000000000004021
  2. Santos, Torcato; Santos, Ana Rita; Almeida, Ana Catarina; Rocha, Ana Cláudia; Reste-Ferreira, Débora; Marques, Inês Pereira; Cunha-Vaz Martinho, António; et al. "Retinal Capillary Nonperfusion in Preclinical Diabetic Retinopathy". Ophthalmic Research 66 1 (2023): 1327-1334. http://dx.doi.org/10.1159/000534553.
    10.1159/000534553
  3. Reste-Ferreira, Débora; Marques, Inês Pereira; Santos, Torcato; Ribeiro, Maria Luísa; Mendes, Luís; Santos, Ana Rita; Lobo, Conceição; Cunha-Vaz, José. "Retinal neurodegeneration in eyes with NPDR risk phenotypes: A two-year longitudinal study". Acta Ophthalmologica (2023): http://dx.doi.org/10.1111/aos.15787.
    10.1111/aos.15787
  4. Cardoso, Elsa M.; Lourenço-Gomes, Vânia; Esgalhado, André J.; Reste-Ferreira, Débora; Oliveira, Nádia; Amaral, Ana Saraiva; Martinho, António; et al. "HLA-A23/HLA-A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma". HLA 102 6 (2023): 660-670. http://dx.doi.org/10.1111/tan.15149.
    10.1111/tan.15149
  5. Marques, Inês P.; Ribeiro, Maria L.; Santos, Torcato P.; Mendes, Luis G.; Reste-Ferreira, Débora; Santos, Ana R.; Lobo, Conceição L.; Cunha-Vaz, José G.. "Different Risk Profiles for Progression of Nonproliferative Diabetic Retinopathy: A 2-Year Study". Ophthalmology and Therapy 12 1 (2022): 485-500. http://dx.doi.org/10.1007/s40123-022-00623-7.
    10.1007/s40123-022-00623-7
  6. Arosa, FA; Esgalhado, AJ; Reste-Ferreira, Débora; Cardoso, Elsa Maria (3D1D-5BC2-1E48); André J. Esgalhado; Débora Reste-Ferreira; Elsa M. Cardoso. "Open MHC Class I Conformers: A Look through the Looking Glass". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/18/9738.
    10.3390/ijms22189738
  7. Esgalhado, André J.; Reste-Ferreira, Débora; Albino, Stephanie E.; Sousa, Adriana; Amaral, Ana Paula; Martinho, António; Oliveira, Isabel T.; et al. "CD45RA, CD8ß, and IFN¿ Are Potential Immune Biomarkers of Human Cognitive Function". Frontiers in Immunology 11 (2020): http://dx.doi.org/10.3389/fimmu.2020.592656.
    10.3389/fimmu.2020.592656
Thesis / Dissertation
  1. Ferreira, Débora. "Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in the control of microglial reactivity". Master, Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, 2018.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/10 Human CD8ßlow T cells are induced in vitro after culture with IL-15: associa-tion with CD8ß isoform changes XVI Annual CICS-UBI Symposium 2021
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde (Covilhã, Portugal)
2020/10/01 CD45RA, CD8ß, HLA-B8 and IFN¿ as Biomarkers that Identify Cognitively Impaired Elderly XV Annual CICS-UBI Symposium 2020
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde (Covilhã, Portugal)
2019/07/04 Preliminary results of the characterization of the immunophenotype in volunteers of the EBIcohort XIV Annual CICS-UBI Symposium 2019
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde (Covilhã, Portugal)
2018/07/05 Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in the control of microglial reactivity XIII Annual CICS-UBI Symposium 2018
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde (Covilhã, Portugal)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/06/14 - 2021/06/18 Attendance at XVII Congress of the Iberian Society of Cytometry
Congress
XVII Congress of the Iberian Society of Cytometry - SIC 2021
Portuguese Institute of Oncology , Portugal
2021/02/16 - 2021/02/17 Attendance at 1st Symposium on Alzheimer´s Disease: An update on pathology and therapeutics
Symposium
1st Symposium on AD: An update on pathology and therapeutics
Universidade do Porto Faculdade de Engenharia, Portugal
2021/01/29 - 2021/01/29 Attendance at the webinar "TSU - Troubleshooting Quantitative PCR (qPCR)" with Mikael Kubista, Ph.D., the pioneer developers of the qPCR field. TSU - Troubleshooting Quantitative PCR (qPCR)
The Scientist Webinars, Portugal
2021/01/27 - 2021/01/27 Workshop "Scientific writing and publishing: practical tips from an editor for your article to succeed" with Maria J. Jerez, Ph.D. , ex-editor of Nature; Publications office of the European Union Scientific writing and publishing: practical tips from an editor for your article to succeed
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/11/26 - 2020/11/26 Attendance at the seminar "Diagnóstico do SARS-CoV-2 por PCR Multiplex em Tempo Real"
Seminar
Diagnóstico do SARS-CoV-2 por PCR Multiplex em Tempo Real
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/10/01 - 2020/10/02 Attendance at the XV Annual CICS-UBI Symposium
Symposium
XV Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/11/14 - 2019/11/16 Attendance at III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
Congress
III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/07/04 - 2019/07/05 Attendance at the XIV Annual CICS-UBI Symposium
Symposium
XIV Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/02/22 - 2019/02/22 Workshop Scientific Writing: an editor perspective with Maria J. Jerez, Ph.D., ex-editor of Nature; Publications office of the European Union Workshop_Scientific Writing: an editor perspective
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/07/05 - 2018/07/06 Attendance at the XIII Annual CICS-UBI Symposium
Symposium
XIII Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/10/12 - 2017/10/14 Attendance at the 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Congress
10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Universidade da Beira Interior, Portugal