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RS received her PhD in Medicine from the Medical Faculty of Porto in 1995. RS PhD project aimed to study the role of diverse oncogenes and tumour supressor genes in the progression of gastric cancer, and identified, for the first time, microsatellite instability (MSI) and MMR repair alterations as a particular molecular subtype of gastric cancer. This work brought RS international recognition in the field of genetics of gastric cancer and stomach related diseases. Further, in colorectal cancer, she addressed the clinical importance of MSI, target genes and oncogenic mutations and established a model of development of BRAF and KRAS associated colorectal carcinomas. In the setting of highly invasive cancers, namely stomach cancer, RS has been involved in determining the importance of cell-cell, cell-matrix interactions and signalling of invasive cancer cells, and how these events promote cancer invasion and metastization. For that purpose, she uses the paradigm model of isolated invasion associated to HDGC (hereditary diffuse gastric cancer) which is mediated by loss of E-cadherin function, a key epithelial marker that is frequently lost in invasive cancer cells with high potential for distant metastization. Due to the work developed throughout her career, RS is regarded as a worldwide expert on cancer cell invasion, namely in gastric and colon cancers. In the context of HDGC, RS is an international reference and a Member of the International Gastric Cancer Linkage Consortium that defines the guidelines for management of patients and families carrying E-cadherin germline mutations. In this context, Seruca´s lab is a worldwide Reference Center in the functional analysis of E-cadherin missense mutations, with a tremendous impact in the clinical surveillance of carriers. Attesting her international recognition and expertise in functional assays for germline sequence variants of E-cadherin, RS has been invited to be a Member of the Scientific Advisory Council of the American Association ¿No Stomach for Cancer¿ that supports families with gastric cancer. RS maintains an international collaborative network with oncologists, pathologists, geneticists, cell biologists, biochemists, surgeons, and bioengineers, and has been involved in developing new bioimaging tools and novel strategies with application to diagnosis and treatment stratification of invasive cancer. In 2009, Raquel Seruca received the distinction ¿Ordem do Infante D. Henrique¿ from the Portuguese Presidency for her Scientific merit, reflecting the recognition of her contribution to research and outreach activities in Portugal. Likewise, in 2014, RS was awarded ¿Medalha de Ouro de Mérito Cientifico¿ by Câmara Municipal do Porto. More recently, in 2018, RS was invited to be a Member of the installing committee of ¿Agência para a Investigação Clínica e Inovação Biomédica - AICIB¿, demonstrative of her visibility in Portugal. Importantly, RS coordinates the Porto. Comprehensive Cancer Centre, a consortium dedicated to the prevention, diagnosis, and innovation in the treatment of cancer. As Principal investigator (PI), RS has been able to raise more than 1.5 million euros, excluding her salary, under competitive funding calls from FCT, NHI and Europe. Raquel Seruca has 263 publications in international peer-reviewed journals with an h-index of 67 (Scopus). RS has publications in TOP journals of her research area: Gastroenterology, Lancet Oncology, New England Journal of Medicine, Human Molecular Genetics, Oncogene, Gut, European Journal of Human Genetics, Scientific Reports, Molecular Cancer.
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Identification

Personal identification

Full name
Raquel Seruca

Citation names

  • Seruca, Raquel

Author identifiers

Ciência ID
AF16-3243-F4EF
ORCID iD
0000-0002-8851-4166
Scopus Author Id
7006207833

Addresses

  • i3S - Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
1995
Concluded
 Doutoramento em Medicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
 Muito Bom por unaminidade
1986
Concluded
 Licenciatura em Medicina (Licenciatura)
Universidade do Porto Faculdade de Medicina, Portugal
 14 valores
Affiliation

Science

Category
Host institution 		Employer
2015 - Current Coordinating Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2000 - 2015 Coordinating Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1999 - 2000 Principal Investigator (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2006 - Current Invited Associate Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal

Positions / Appointments

Category
Host institution 		Employer
2010 - Current Vice-President Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Others

Category
Host institution 		Employer
1999 - Current Member of the International Gastric Cancer Linkage Consortium International Gastric Cancer Linkage Consortium, United Kingdom
2015 - 2019 Coordinator of Cancer Integrative Program Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
1998 - 1999 Post-Doctoral fellow Rijksuniversiteit Groningen, Netherlands
Rijksuniversiteit Groningen, Netherlands
1995 - 1998 Post-Doctoral fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Grant

Designation Funders
2021/03 - 2024/02 Nuclear biomarkers for predictive prognosis of hereditary diffuse gastric cancer
NICE
Principal investigator
No Stomach for Cancer, Inc, United States
 No Stomach for Cancer, Inc
Ongoing
2018 - 2021 CAPTURE - Mechanodependent capture of circulating tumour cells: a cell-ECM based approach coupled with cancer specific glycomarkers
PTDC/BTM-SAL/30383/2017
 Fundação para a Ciência e a Tecnologia
2018 - 2021 E-RISK - Oral facial congenital malformations and gastric cancer risk: a matter of E-cadherin mediated cell-extracellular matrix adhesion
PTDC/MED/GEN/30356/2017
 Fundação para a Ciência e a Tecnologia
2017 - 2019 STOMACH - Today´s present, Tomorrow´s future on the study of germline E-cadherin missense mutations: A step forward on providing informed genetic counselling to everyone
STOMACH
 No Stomach for Cancer, Inc
2016 - 2019 TRACE-Tracing gastric cancer using quantitative bioimaging analysis
PTDC/BBB-IMG/0283/2014
 Fundação para a Ciência e a Tecnologia
2016 - 2019 E-cadherin loss in the process of cell invasion in cancer
NORTE-01-0145-FEDER-000029
 NORTE 2020
2016/01 - 2018/12 Sensing dysfunctional E-cadherin cells in gastric epithelia (SENSE)
Provided by PTCRIS: 138871
 Fundação para a Ciência e a Tecnologia
2015 - 2017 MISS - Today´s present, tomorrow´s future on the study of germline E-cadherin missense mutations
MISS
 No Stomach for Cancer, Inc
2014/01 - 2015/12 Incentive - LA 3 - 2014
Provided by PTCRIS: 137387
 Fundação para a Ciência e a Tecnologia
2013/06 - 2015/09 Mutant E-Cadherin and Novel Interactors in Cancer (MECANIC). The role of mutant E-cadherin-integrin-ECM crosstalk in gastric cancer.
Provided by PTCRIS: 124283
 Fundação para a Ciência e a Tecnologia
2013 - 2015 Molecular mechanisms underlying cancer cell invasion in two disease models, gastric and breast
NORTE-07-0124-FEDER-000022
 ON - Novo Norte; FEDER; Programa Operacional Regional do Norte
2011/04 - 2014/09 Tumour spectrum in Hereditary Diffuse Gastric Cancer
Provided by PTCRIS: 110294
 Fundação para a Ciência e a Tecnologia
2010/06 - 2013/11 The role of Protein Quality Control in the regulation of E-cadherin and its relevance in cancer.
Provided by PTCRIS: 104017
 Fundação para a Ciência e a Tecnologia
2010/01 - 2013/06 Bacterial protein azurin as a new candidate drug to treat poor-prognosis breast cancer
Provided by PTCRIS: 100326
 Fundação para a Ciência e a Tecnologia
2009/01 - 2012/07 Exploring the role of E-Cadherin-HER interaction in the search of molecular biomarkers for the clinical management of gastric cancer patients
Provided by PTCRIS: 82923
 Fundação para a Ciência e a Tecnologia
2009/01 - 2011/12 Implementation of a Nacional Facility for DNA Microarrays: Phase II
Provided by PTCRIS: 64745
 Fundação para a Ciência e a Tecnologia
2008/07 - 2011/12 MLK3, a new mutated gene in MSI colorectal cancer
Provided by PTCRIS: 68310
 Fundação para a Ciência e a Tecnologia
2008/02 - 2011/04 Exploring the role of E-cadherin trafficking deregulation in epithelial cancer progression.
Provided by PTCRIS: 64319
 Fundação para a Ciência e a Tecnologia
2007/08 - 2010/12 Targeting nanoprobes for early detection of invasive cancer cells using Hereditary Diffuse Gastric Cancer as a model
Provided by PTCRIS: 69901
 Fundação para a Ciência e a Tecnologia
2007/08 - 2010/11 Papel de novos mechanismos regulatórios na perda de expressão da caderina-E
Provided by PTCRIS: 72168
 Fundação para a Ciência e a Tecnologia
2005/09 - 2008/08 Functional analysis of the E-cadherin repressors (Slug, ZEB1 and E12/E47) in gastric cancer
Provided by PTCRIS: 57275
 Fundação para a Ciência e a Tecnologia
2005/07 - 2008/06 In mismatch repair deficiency colorectal cancer are BRAF and KRAS new prognostic and therapeutic tools?
Provided by PTCRIS: 56921
 Fundação para a Ciência e a Tecnologia
2005/07 - 2008/06 Identification of molecular mechanisms underlying gastric cancer in families positive and negative for E-cadherin germline mutations
Provided by PTCRIS: 58111
 Fundação para a Ciência e a Tecnologia
2005/09 - 2008/01 E-cadherin germline missense mutations and hereditary diffuse gastric cancer: a model for the identification of the E-cadherin-dependent signaling pathways pivotal for cell invasion
Provided by PTCRIS: 57670
 Fundação para a Ciência e a Tecnologia
2004/07 - 2004/12 E-cadherin germline missense mutations and hereditary diffuse gastric cancer: a model for the identification of the E-cadherin-dependent signaling pathways pivotal for cell invasion
e27529af1f582d20e4da2e76e4a9ff9e
 Terry Fox Foundation
Outputs

Publications

Book
  1. Seruca, R.; Suri, J.S.; Sanches, J.M.. Preface. 2017.
  2. Seruca, R.; Suri, J.S.; Sanches, J.M.. Fluorescence Imaging and Biological Quantification. 2017.
    10.1201/9781315121017
  3. Figueiredo, J.; Seruca, R.. Germline missense mutants in hereditary diffuse gastric cancer. 2013.
    10.1007/978-94-007-6570-2_7
  4. Leite, M.; Corso, G.; Sousa, S.; Carvalho, J.; Roviello, F.; Oliveira, C.; Figueiredo, C.; Seruca, R.. Non- CDH1 -associated familial gastric cancer and epigenetics factors. 2013.
    10.1007/978-94-007-6570-2_10
Book chapter
  1. Fernandes, M.S.; Sanches, J.M.; Seruca, R.. "Targeting the PI3K signalling as a therapeutic strategy in colorectal cancer". 35-53. 2018.
    10.1007/978-3-030-02771-1_4
  2. Fernandes, M.S.; Ferro, A.; Carneiro, P.; Seruca, R.; Sanches, J.M.. "Quantum dots: Concepts, imaging, and therapeutic applications in cancer". 105-118. 2017.
  3. Figueiredo, J.; Ribeiro, A.S.; Mestre, T.; Esménio, S.; Fonseca, M.; Paredes, J.; Seruca, R.; Sanches, J.M.. "Capturing quantitative features of protein expression from in situ fluorescence microscopic images of cancer cell populations". 279-297. 2017.
  4. Ferro, A.; Carneiro, P.; Fernandes, M.S.; Mestre, T.; Sanches, J.M.; Seruca, R.. "Illuminating the cycle of life". 201-230. 2017.
Journal article
  1. Figueiredo, J.; Ferreira, R.M.; Xu, H.; Gonçalves, M.; Barros-Carvalho, A.; Cravo, J.; Maia, A.F.; et al. "Integrin ß1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells". Gastric Cancer 25 1 (2022): 124-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114350265&partnerID=MN8TOARS.
    10.1007/s10120-021-01239-9
  2. Ringborg, U.; Berns, A.; Celis, J.E.; Heitor, M.; Tabernero, J.; Schüz, J.; Baumann, M.; et al. "The Porto European Cancer Research Summit 2021". Molecular Oncology 15 10 (2021): 2507-2543. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114897969&partnerID=MN8TOARS.
    10.1002/1878-0261.13078
  3. Figueiredo, J.; Mercadillo, F.; Melo, S.; Barroso, A.; Gonçalves, M.; Díaz-Tasende, J.; Carneiro, P.; et al. "Germline cdh1 g212e missense variant: Combining clinical, in vitro and in vivo strategies to unravel disease Burden". Cancers 13 17 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85113807006&partnerID=MN8TOARS.
    10.3390/cancers13174359
  4. Narotamo, H.; Fernandes, M.S.; Moreira, A.M.; Melo, S.; Seruca, R.; Silveira, M.; Sanches, J.M.. "A machine learning approach for single cell interphase cell cycle staging". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85116364785&partnerID=MN8TOARS.
    10.1038/s41598-021-98489-5
  5. Moreira, Ana Margarida; Pereira, Joana; Melo, Soraia; Fernandes, Maria Sofia; Carneiro, Patrícia; Seruca, Raquel; Figueiredo, Joana. "The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression". Cells 9 2 (2020): 394. http://dx.doi.org/10.3390/cells9020394.
    Published • 10.3390/cells9020394
  6. Blair, V.R.; McLeod, M.; Carneiro, F.; Coit, D.G.; D'Addario, J.L.; van Dieren, J.M.; Harris, K.L.; et al. "Hereditary diffuse gastric cancer: updated clinical practice guidelines". The Lancet Oncology 21 8 (2020): e386-e397. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088930288&partnerID=MN8TOARS.
    10.1016/S1470-2045(20)30219-9
  7. Corso, G.; Figueiredo, J.; De Angelis, S.P.; Corso, F.; Girardi, A.; Pereira, J.; Seruca, R.; et al. "E-cadherin deregulation in breast cancer". Journal of Cellular and Molecular Medicine 24 11 (2020): 5930-5936. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083449791&partnerID=MN8TOARS.
    10.1111/jcmm.15140
  8. Corso, G.; Montagna, G.; Figueiredo, J.; Vecchia, C.L.; Romario, U.F.; Fernandes, M.S.; Seixas, S.; et al. "Hereditary gastric and breast cancer syndromes related to CDH1 germline mutation: A multidisciplinary clinical review". Cancers 12 6 (2020): 1-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85086649941&partnerID=MN8TOARS.
    10.3390/cancers12061598
  9. Leite, M.; Marques, M.S.; Melo, J.; Pinto, M.T.; Cavadas, B.; Aroso, M.; Gomez-Lazaro, M.; Seruca, R.; Figueiredo, C.. "Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions". Cells 9 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086741184&partnerID=MN8TOARS.
    10.3390/cells9020513
  10. Carvalho, P.D.; Machado, A.L.; Martins, F.; Seruca, R.; Velho, S.. "Targeting the tumor microenvironment: An unexplored strategy for mutant KRAS tumors". Cancers 11 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077305268&partnerID=MN8TOARS.
    10.3390/cancers11122010
  11. Carneiro, P.; Moreira, A.M.; Figueiredo, J.; Barros, R.; Oliveira, P.; Fernandes, M.S.; Ferro, A.; et al. "S100P is a molecular determinant of E-cadherin function in gastric cancer". Cell Communication and Signaling 17 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075548008&partnerID=MN8TOARS.
    10.1186/s12964-019-0465-9
  12. Figueiredo, J.; Melo, S.; Carneiro, P.; Moreira, A.M.; Fernandes, M.S.; Ribeiro, A.S.; Guilford, P.; Paredes, J.; Seruca, R.. "Clinical spectrum and pleiotropic nature of CDH1 germline mutations". Journal of Medical Genetics 56 4 (2019): 199-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060236556&partnerID=MN8TOARS.
    10.1136/jmedgenet-2018-105807
  13. Pena-Couso, L.; Perea, J.; Melo, S.; Mercadillo, F.; Figueiredo, J.; Sanches, J.M.; Sánchez-Ruiz, A.; et al. "Clinical and functional characterization of the CDH1 germline variant c.1679C>G in three unrelated families with hereditary diffuse gastric cancer". European Journal of Human Genetics 26 9 (2018): 1348-1353. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046998829&partnerID=MN8TOARS.
    10.1038/s41431-018-0173-8
  14. Ribeiro, A.S.; Nobre, A.R.; Mendes, N.; Almeida, J.; Vieira, A.F.; Sousa, B.; Carvalho, F.A.; et al. "SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells". Cell communication and signaling : CCS 16 1 (2018): 75-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056432555&partnerID=MN8TOARS.
    10.1186/s12964-018-0286-2
  15. Figueiredo, J.; Melo, S.; Gamet, K.; Godwin, T.; Seixas, S.; Sanches, J.M.; Guilford, P.; Seruca, R.. "E-cadherin signal sequence disruption: A novel mechanism underlying hereditary cancer". Molecular Cancer 17 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85051027654&partnerID=MN8TOARS.
    10.1186/s12943-018-0859-0
  16. Figueiredo, J.; Rodrigues, I.; Ribeiro, J.; Fernandes, M.S.; Melo, S.; Sousa, B.; Paredes, J.; Seruca, R.; Sanches, J.M.. "Geometric compensation applied to image analysis of cell populations with morphological variability: A new role for a classical concept". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049644419&partnerID=MN8TOARS.
    10.1038/s41598-018-28570-z
  17. Corso, G.; Figueiredo, J.; La Vecchia, C.; Veronesi, P.; Pravettoni, G.; Macis, D.; Karam, R.; et al. "Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect". Journal of Medical Genetics 55 7 (2018): 431-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049325623&partnerID=MN8TOARS.
    10.1136/jmedgenet-2018-105337
  18. Zollinger, A.J.; Xu, H.; Figueiredo, J.; Paredes, J.; Seruca, R.; Stamenovic, D.; Smith, M.L.. "Dependence of Tensional Homeostasis on Cell Type and on Cell–Cell Interactions". Cellular and Molecular Bioengineering 11 3 (2018): 175-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046688489&partnerID=MN8TOARS.
    10.1007/s12195-018-0527-x
  19. Melo, S.; Figueiredo, J.; Fernandes, M.S.; Gonçalves, M.; Morais-De-Sá, E.; Sanches, J.M.; Seruca, R.. "Predicting the functional impact of CDH1 missense mutations in hereditary diffuse gastric cancer". International Journal of Molecular Sciences 18 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85038807279&partnerID=MN8TOARS.
    10.3390/ijms18122687
  20. Ferro, A.; Mestre, T.; Carneiro, P.; Sahumbaiev, I.; Seruca, R.; Sanches, J.M.. "Blue intensity matters for cell cycle profiling in fluorescence DAPI-stained images". Laboratory Investigation 97 5 (2017): 615-625. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019626964&partnerID=MN8TOARS.
    10.1038/labinvest.2017.13
  21. Carvalho, S.; Catarino, T.A.; Dias, A.M.; Kato, M.; Almeida, A.; Hessling, B.; Figueiredo, J.; et al. "Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer". Oncogene 35 13 (2016): 1619-1631. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937605601&partnerID=MN8TOARS.
    10.1038/onc.2015.225
  22. Mestre, T.; Figueiredo, J.; Ribeiro, A.S.; Paredes, J.; Seruca, R.; Sanches, J.M.. "Quantification of topological features in cell meshes to explore E-cadherin dysfunction". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84971367761&partnerID=MN8TOARS.
    10.1038/srep25101
  23. Pinto, A.T.; Pinto, M.L.; Velho, S.; Pinto, M.T.; Cardoso, A.P.; Figueira, R.; Monteiro, A.; et al. "Intricate macrophage-colorectal cancer cell communication in response to radiation". PLoS ONE 11 8 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84983567727&partnerID=MN8TOARS.
    10.1371/journal.pone.0160891
  24. Carvalho, S.; Oliveira, T.; Bartels, M.F.; Miyoshi, E.; Pierce, M.; Taniguchi, N.; Carneiro, F.; et al. "O-mannosylation and N-glycosylation: Two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer". Oncotarget 7 40 (2016): 65231-65246. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993660248&partnerID=MN8TOARS.
    10.18632/oncotarget.11245
  25. Teresa Pinto, A.; Laranjeiro Pinto, M.; Patrícia Cardoso, A.; Monteiro, C.; Teixeira Pinto, M.; Filipe Maia, A.; Castro, P.; et al. "Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84954288518&partnerID=MN8TOARS.
    10.1038/srep18765
  26. Ribeiro, A.S.; Carvalho, F.A.; Figueiredo, J.; Carvalho, R.; Mestre, T.; Monteiro, J.; Guedes, A.F.; et al. "Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells". Nanoscale 8 46 (2016): 19390-19401. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998881935&partnerID=MN8TOARS.
    10.1039/c6nr04465d
  27. Branco da Cunha, C.; Klumpers, D.D.; Koshy, S.T.; Weaver, J.C.; Chaudhuri, O.; Seruca, R.; Carneiro, F.; Granja, P.L.; Mooney, D.J.. "CD44 alternative splicing in gastric cancer cells is regulated by culture dimensionality and matrix stiffness". Biomaterials 98 (2016): 152-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966708392&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2016.04.016
  28. Fernandes, M.S.; Melo, S.; Velho, S.; Carneiro, P.; Carneiro, F.; Seruca, R.. "Specific inhibition of p110a subunit of PI3K: Putative therapeutic strategy for KRAS mutant colorectal cancers". Oncotarget 7 42 (2016): 68546-68558. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014747304&partnerID=MN8TOARS.
  29. Zhang, L.; Xiao, A.; Ruggeri, J.; Bacares, R.; Somar, J.; Iqbal, S.; Ricker, C.; et al. "Corrigendum to "The germline CDH1 c.48 G > C substitution contributes to cancer predisposition through generation of a pro-invasive mutation" [Mutat. Res. 770, (2014), 106-111]". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 774 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927547974&partnerID=MN8TOARS.
    10.1016/j.mrfmmm.2015.04.001
  30. Brito, L.A.; Yamamoto, G.L.; Melo, S.; Malcher, C.; Ferreira, S.G.; Figueiredo, J.; Alvizi, L.; et al. "Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate". Human Mutation 36 11 (2015): 1029-1033. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944156790&partnerID=MN8TOARS.
    10.1002/humu.22827
  31. van der Post, R.S.; Vogelaar, I.P.; Carneiro, F.; Guilford, P.; Huntsman, D.; Hoogerbrugge, N.; Caldas, C.; et al. "Hereditary diffuse gastric cancer: Updated clinical guidelines with an emphasis on germline CDH1 mutation carriers". Journal of Medical Genetics 52 6 (2015): 361-374. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930650698&partnerID=MN8TOARS.
    10.1136/jmedgenet-2015-103094
  32. Vedeld, H.M.; Andresen, K.; Eilertsen, I.A.; Nesbakken, A.; Seruca, R.; Gladhaug, I.P.; Thiis-Evensen, E.; et al. "The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers". International Journal of Cancer 136 4 (2015): 844-853. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918780619&partnerID=MN8TOARS.
    10.1002/ijc.29039
  33. Sanches, J.M.; Figueiredo, J.; Fonseca, M.; Durães, C.; Melo, S.; Esménio, S.; Seruca, R.. "Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants". European Journal of Human Genetics 23 8 (2015): 1072-1079. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937515858&partnerID=MN8TOARS.
    10.1038/ejhg.2014.240
  34. Alves, S.; Castro, L.; Fernandes, M.S.; Francisco, R.; Castro, P.; Priault, M.; Chaves, S.R.; et al. "Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy". Oncotarget 6 31 (2015): 30787-30802. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945530861&partnerID=MN8TOARS.
    10.18632/oncotarget.5021
  35. Pinheiro, M.; Pinto, C.; Peixoto, A.; Veiga, I.; Lopes, P.; Henrique, R.; Baldaia, H.; et al. "Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation". British Journal of Cancer 113 4 (2015): 686-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939264921&partnerID=MN8TOARS.
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  207. Carvalho, B.; Seruca, R.; Carneiro, F.; Buys, C.H.C.M.; Kok, K.. "Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1". Genes Chromosomes and Cancer 26 1 (1999): 29-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032841006&partnerID=MN8TOARS.
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  208. Munar-Qués, M.; Pedrosa, J.L.; Coelho, T.; Gusmão, L.; Seruca, R.; Amorim, A.; Sequeiros, J.. "Two pairs of proven monozygotic twins discordant for familial amyloid neuropathy (FAP) TTR Met 30". Journal of Medical Genetics 36 8 (1999): 629-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032803525&partnerID=MN8TOARS.
  209. Carvalho, B.; Seruca, R.; Carneiro, F.; Buys, C.H.C.M.; Kok, K.. "Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1". Genes Chromosomes and Cancer 26 1 (1999): 29-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032841006&partnerID=MN8TOARS.
    10.1002/(SICI)1098-2264(199909)26:1<29::AID-GCC4>3.0.CO;2-D
  210. Schmitt, F.C.; Soares, R.; Gobbi, H.; Milanezzi, F.; Santos-Silva, F.; Cirnes, L.; Costa, C.; Seruca, R.. "Microsatellite instability in medullary breast carcinomas". International Journal of Cancer 84 5 (1999): 644-647. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033609731&partnerID=MN8TOARS.
  211. Carneiro, F.; Machado, J.C.; Seruca, R.; Sobrinho-Simoes, M.. "E-cadherin changes in gastric carcinoma [2]". Histopathology 35 5 (1999): 477-478. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032731166&partnerID=MN8TOARS.
    10.1046/j.1365-2559.1999.035005477.x
  212. Caldas, C.; Carneiro, F.; Lynch, H.T.; Yokota, J.; Wiesner, G.L.; Powell, S.M.; Lewis, F.R.; et al. "Familial gastric cancer: Overview and guidelines for management". Journal of Medical Genetics 36 12 (1999): 873-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033432725&partnerID=MN8TOARS.
  213. Maximo, V.; Soares, P.; Seruca, R.; Sobrinho-Simoes, M.. "Comments on: Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients, Tamura, et al. Eur J Cancer 1999, 35, 316-319". European Journal of Cancer 35 9 (1999): 1407-1408. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032766997&partnerID=MN8TOARS.
    10.1016/S0959-8049(99)00126-4
  214. Nogueira, A.M.M.F.; Cameiro, F.; Seruca, R.; Cirnes, L.; Veiga, I.; Machado, J.C.; Sobrinho-Simões, M.. "Microsatellite instability in hyperplastic and adenomatous polyps of the stomach". Cancer 86 9 (1999): 1649-1656. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344631745&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0142(19991101)86:9<1649::AID-CNCR5>3.0.CO;2-N
  215. Nogueira, A.M.M.F.; Cameiro, F.; Seruca, R.; Cirnes, L.; Veiga, I.; Machado, J.C.; Sobrinho-Simões, M.. "Microsatellite instability in hyperplastic and adenomatous polyps of the stomach". Cancer 86 9 (1999): 1649-1656. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344631745&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0142(19991101)86:9<1649::AID-CNCR5>3.0.CO;2-N
  216. Schmitt, F.C.; Soares, R.; Cirnes, L.; Seruca, R.. "PCR amplification of DNA obtained from archived hematoxylin-eosin-and giemsa-stained breast cancer aspirates". Diagnostic Cytopathology 19 5 (1998): 395-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031733732&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0339(199811)19:5<395::AID-DC19>3.0.CO;2-4
  217. Lopes, J.M.; Silva, P.; Seixas, M.; Cirnes, L.; Seruca, R.. "Microsatellite instability is not associated with degree of malignancy and p53 expression of gastrointestinal stromal tumours [4]". Histopathology 33 6 (1998): 579-581. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031646340&partnerID=MN8TOARS.
  218. Zhou, X.-P.; Hoang, J.-M.; Li, Y.-J.; Seruca, R.; Carneiro, F.; Sobrinho-Simoes, M.; Lothe, R.A.; et al. "Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites". Genes Chromosomes and Cancer 21 2 (1998): 101-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031938045&partnerID=MN8TOARS.
    10.1002/(SICI)1098-2264(199802)21:2<101::AID-GCC4>3.0.CO;2-4
  219. Peixoto, A.; Dos Santos, M.R.; Seruca, R.; Amorim, A.; Castedo, S.. "Analysis of FMR1 and flanking microsatellite markers in normal and fragile X chromosomes in Portugal: Evidence for a 'protector' haplotype". European Journal of Human Genetics 6 5 (1998): 518-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031734362&partnerID=MN8TOARS.
  220. Gayther, S.A.; Gorringe, K.L.; Ramus, S.J.; Huntsman, D.; Roviello, F.; Grehan, N.; Machado, J.C.; et al. "Identification of germ-line E-cadherin mutations in gastric cancer families of European origin". Cancer Research 58 18 (1998): 4086-4089. http://www.scopus.com/inward/record.url?eid=2-s2.0-19244377605&partnerID=MN8TOARS.
  221. Zhou, X.-P.; Hoang, J.-M.; Li, Y.-J.; Seruca, R.; Carneiro, F.; Sobrinho-Simoes, M.; Lothe, R.A.; et al. "Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites". Genes Chromosomes and Cancer 21 2 (1998): 101-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031938045&partnerID=MN8TOARS.
    10.1002/(SICI)1098-2264(199802)21:2<101::AID-GCC4>3.0.CO;2-4
  222. Schmitt, F.C.; Soares, R.; Cirnes, L.; Seruca, R.. "P53 in breast carcinomas: Association between presence of mutation and immunohistochemical expression using a semiquantitative approach". Pathology Research and Practice 194 12 (1998): 815-819. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032437296&partnerID=MN8TOARS.
  223. Schmitt, F.C.; Soares, R.; Seruca, R.. "Bilateral apocrine carcinoma of the breast: Molecular and immunocytochemical evidence for two independent primary tumours". Virchows Archiv 433 6 (1998): 505-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031743447&partnerID=MN8TOARS.
    10.1007/s004280050281
  224. Oliveira, C.; Seruca, R.; Seixas, M.; Sobrinho-Simões, M.. "The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different 'target genes': A study of the TGFß RII, IGFII R, and BAX genes". American Journal of Pathology 153 4 (1998): 1211-1219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031710793&partnerID=MN8TOARS.
  225. Schmitt, F.C.; Soares, R.; Cirnes, L.; Seruca, R.. "PCR amplification of DNA obtained from archived hematoxylin-eosin-and giemsa-stained breast cancer aspirates". Diagnostic Cytopathology 19 5 (1998): 395-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031733732&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0339(199811)19:5<395::AID-DC19>3.0.CO;2-4
  226. Seruca, R.; Sobrinho-Simoes, M.; Hayden, J.D.; Martin, I.G.. "Assessment of microsatellite alterations in young patients with gastric adenocarcinoma [2] (multiple letters)". Cancer 80 7 (1997): 1358-1360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030886947&partnerID=MN8TOARS.
  227. Carvalho, F.; Seruca, R.; David, L.; Amorim, A.; Seixas, M.; Bennett, E.; Clausen, H.; Sobrinho-Simões, M.. "MUC1 gene polymorphism and gastric cancer an epidemiological study". Glycoconjugate Journal 14 1 (1997): 107-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031058867&partnerID=MN8TOARS.
    10.1023/A:1018573201347
  228. Silva, F.; Gusmão, L.; Alves, C.; Seruca, R.; David, L.; Amorim, A.. "Tetra- and pentanucleotide short tandem repeat instability in gastric cancer". Electrophoresis 18 9 (1997): 1633-1636. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030833238&partnerID=MN8TOARS.
    10.1002/elps.1150180926
  229. Soares, P.; Dos Santos, N.R.; Seruca, R.; Lothe, R.A.; Sobrinho-Simo¿s, M.. "Benign and malignant thyroid lesions show instability at microsatellite loci". European Journal of Cancer Part A 33 2 (1997): 293-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030939160&partnerID=MN8TOARS.
    10.1016/S0959-8049(96)00457-1
  230. Seruca, R.; David, L.; Sobrinho-Simões, M.. "Relationship between the expression of p53 and the aggressiveness of gastric carcinoma.". The Journal of pathology 181 3 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0031089801&partnerID=MN8TOARS.
  231. Dos Santos, N.R.; Seruca, R.; Constancia, M.; Seixas, M.; Sobrinho-Simoes, M.. "Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis". Gastroenterology 110 1 (1996): 38-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030061373&partnerID=MN8TOARS.
    10.1053/gast.1996.v110.pm8536886
  232. Gärtner, F.; David, L.; Seruca, R.; Machado, J.C.; Sobrinho-Simões, M.. "Establishment and characterization of two cell lines derived from human diffuse gastric carcinomas xenografted in nude mice". Virchows Archiv 428 2 (1996): 91-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030000111&partnerID=MN8TOARS.
  233. Queimado, L.; Seruca, R.; Costa-Pereira, A.; Castedo, S.. "Identification of two distinct regions of deletion at 6q in gastric carcinoma". Genes Chromosomes and Cancer 14 1 (1995): 28-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029092711&partnerID=MN8TOARS.
    10.1002/gcc.2870140106
  234. Seruca, R.; Constancia, M.; Dos Santos, N.R.; David, L.; Queimado, L.; Carvalho, F.; Carneiro, F.. "Allele loss in human gastric carcinomas: Relation to tumor progression and differentiation". International Journal of Oncology 7 5 (1995): 1159-1166. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029557116&partnerID=MN8TOARS.
  235. Seruca, R.; Santos, N.R.; David, L.; Constancia, M.; Barroca, H.; Carneiro, F.; Seixas, M.; et al. "Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile". International Journal of Cancer 64 1 (1995): 32-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028900007&partnerID=MN8TOARS.
    10.1002/ijc.2910640108
  236. Seruca, R.; Suijkerbuijk, R.F.; Gärtner, F.; Criado, B.; Veiga, I.; Olde-Weghuis, D.; David, L.; Castedo, S.; Sobrinho-Simões, M.. "Increasing levels of MYC and MET co-amplification during tumor progression of a case of gastric cancer". Cancer Genetics and Cytogenetics 82 2 (1995): 140-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029122417&partnerID=MN8TOARS.
    10.1016/0165-4608(95)00033-L
  237. Criado, B.; Barros, A.; Suijkerbuijk, R.F.; Weghuis, D.O.; Seruca, R.; Fonseca, E.; Castedo, S.. "Detection of numerical alterations for chromosomes 7 and 12 in benign thyroid lesions by in situ hybridization: Histological implications". American Journal of Pathology 147 1 (1995): 136-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029076415&partnerID=MN8TOARS.
  238. De Leeuw, B.; Balemans, M.; Olde Weghuis, D.; Seruca, R.; Janz, M.; Geraghty, M.T.; Gilgenkrantz, S.; Ropers, H.H.; Geurts Van Kessel, A.. "Molecular cloning of the synovial sarcoma-specific translocation (X;18)(p11.2;q11.2) breakpoint". Human Molecular Genetics 3 5 (1994): 745-749. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028350595&partnerID=MN8TOARS.
    10.1093/hmg/3.5.745
  239. Seruca, R.; David, L.; Castedo, S.; Veiga, I.; Borresen, A.-L.; Sobrinho-Simoes, M.. "p53 Alterations in gastric carcinoma: A study of 56 primary tumors and 204 nodal metastases". Cancer Genetics and Cytogenetics 75 1 (1994): 45-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028167782&partnerID=MN8TOARS.
    10.1016/0165-4608(94)90214-3
  240. Carneiro, F.; Seruca, R.; Ribeiro, A.C.; Simoes, M.S.; Teh, M.; Yoke Sun Lee. "An immunohistochemical study of ras oncoprotein expression in gastric carcinoma [6]". Cancer 73 7 (1994): 2010-2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028206692&partnerID=MN8TOARS.
    10.1002/1097-0142(19940401)73:7<2010::AID-CNCR2820730741>3.0.CO;2-7
  241. Constância, M.; Seruca, R.; Carneiro, F.; Silva, F.; Castedo, S.. "Retinoblastoma gene structure and product expression in human gastric carcinomas". British Journal of Cancer 70 5 (1994): 1018-1024. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027949365&partnerID=MN8TOARS.
    10.1038/bjc.1994.441
  242. Lopes, J.M.; Seruca, R.; Sobrinho-Simões, M.. "Critical Commentary". Pathology Research and Practice 189 4 (1993): 473-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-0004552908&partnerID=MN8TOARS.
    10.1016/S0344-0338(11)80341-9
  243. Seruca, R.; Castedo, S.; Correia, C.; Gomes, P.; Carneiro, F.; Soares, P.; de Jong, B.; Sobrinho-Simões, M.. "Cytogenetic findings in eleven gastric carcinomas". Cancer Genetics and Cytogenetics 68 1 (1993): 42-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027283862&partnerID=MN8TOARS.
    10.1016/0165-4608(93)90072-T
  244. Peltomaki, P.; Lothe, R.A.; Aaltonen, L.A.; Pylkkanen, L.; Nystrom-Lahti, M.; Seruca, R.; David, L.; et al. "Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome". Cancer Research 53 24 (1993): 5853-5855. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027140481&partnerID=MN8TOARS.
  245. Carneiro, F.; David, L.; Seruca, R.; Castedo, S.; Nesland, J.M.; Sobrinho-Simoes, M.. "Hyperplastic polyposis and diffuse carcinoma of the stomach: A study of a family". Cancer 72 2 (1993): 323-329. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027154614&partnerID=MN8TOARS.
    10.1002/1097-0142(19930715)72:2<323::AID-CNCR2820720204>3.0.CO;2-G
  246. Lothe, R.A.; Saeter, G.; Danielsen, H.E.; Stenwig, A.E.; Hoyheim, B.; O'Connell, P.O.; Borresen, A.-L.; et al. "Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1)". Pathology Research and Practice 189 4 (1993): 465-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027159475&partnerID=MN8TOARS.
  247. David, L.; Seruca, R.; Nesland, J.M.; Soares, P.; Sansonetty, F.; Holm, R.; Børresen, A.L.; Sobrinho-Simões, M.. "c-erbB-2 expression in primary gastric carcinomas and their metastases.". Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 5 4 (1992): 384-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026886442&partnerID=MN8TOARS.
  248. Castedo, S.; Correia, C.; Gomes, P.; Seruca, R.; Soares, P.; Carneiro, F.; Sobrinho-Simões, M.. "Loss of Y chromosome in gastric carcinoma. Fact or artifact?". Cancer Genetics and Cytogenetics 61 1 (1992): 39-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026688768&partnerID=MN8TOARS.
    10.1016/0165-4608(92)90367-H
  249. Seruca, R.; David, L.; Holm, R.; Nesland, J.M.; Fangan, B.M.; Castedo, S.; Sobrinho-Simoes, M.; Borresen, A.-L.. "P53 mutations in gastric carcinomas". British Journal of Cancer 65 5 (1992): 708-710. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026523480&partnerID=MN8TOARS.
    10.1038/bjc.1992.149
  250. Seruca, R.; Carneiro, F.; Soares, P.; Fonseca, E.; Castedo, S.. "Clonal cytogenetic abnormalities and telomeric associations in a fibroxanthoma of the stomach". Genes Chromosomes and Cancer 5 4 (1992): 407-409. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026719445&partnerID=MN8TOARS.
    10.1002/gcc.2870050418
  251. Seruca, R.; Carneiro, F.; Castedo, S.; David, L.; Lopes, C.; Sobrinho-Simoes, M.. "Familial gastric polyposis revisited: Autosomal dominant inheritance confirmed". Cancer Genetics and Cytogenetics 53 1 (1991): 97-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025829590&partnerID=MN8TOARS.
    10.1016/0165-4608(91)90119-F
  252. Lopes, JosM.; Seruca, R.; Hall, A.P.; Branco, P.; Castedo, S.M.M.J.. "Cytogenetic study of a sclerosing stromal tumor of the ovary". Cancer Genetics and Cytogenetics 49 1 (1990): 103-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025052149&partnerID=MN8TOARS.
    10.1016/0165-4608(90)90169-B
  253. Molenaar, W.M.; DeJong, B.; Buist, J.; Idenburg, V.J.S.; Seruca, R.; Vos, A.M.; Hoekstra, H.J.. "Chromosomal analysis and the classification of soft tissue sarcomas". Laboratory Investigation 60 2 (1989): 266-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024581053&partnerID=MN8TOARS.
  254. Castedo, S.M.M.J.; De Jong, B.; Oosterhuis, J.W.; Seruca, R.; Te Meerman, G.J.; Dam, A.; Koops, H.S.. "Cytogenetic analysis of ten human seminomas". Cancer Research 49 2 (1989): 439-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024545210&partnerID=MN8TOARS.
  255. Oosterhuis, J.W.; Castedo, S.M.M.J.; De Jong, B.; Seruca, R.; Dam, A.; Vos, A.; De Koning, J.; Schraffordt Koops, H.; Sleijfer, D.T.. "A malignant mixed gonadal stromal tumor of the testis with heterologous components and i(12p) in one of its metastases". Cancer Genetics and Cytogenetics 41 1 (1989): 105-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024441365&partnerID=MN8TOARS.
    10.1016/0165-4608(89)90114-3
  256. Castedo, S.M.M.J.; De Jong, B.; Oosterhuis, J.W.; Idenburg, V.J.S.; Seruca, R.; Buist, J.; Te Meerman, G.J.; Schraffordt Koops, H.; Sleijfer, D.T.. "Chromosomal changes in mature residual teratomas following polychemotherapy". Cancer Research 49 3 (1989): 672-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024592021&partnerID=MN8TOARS.
  257. Castedo, S.M.M.J.; De Jong, B.; Wolter Oosterhuis, J.; Seruca, R.; Idenburg, V.J.S.; Dam, A.; Te Meerman, G.; Schraffordt Koops, H.; Sleijfer, D.T.. "Chromosomal changes in human primary testicular nonseminomatous germ cell tumors". Cancer Research 49 20 (1989): 5696-5701. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024457239&partnerID=MN8TOARS.
  258. Castedo, S.M.M.J.; De Jong, B.; Oosterhuis, J.W.; Seruca, R.; Idenburg, V.J.; Buist, J.; Sleijfer, D.T.. "i(12p)-Negative testicular germ cell tumors. A different group?". Cancer Genetics and Cytogenetics 35 2 (1988): 171-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024237328&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90239-7
  259. Oosterhuis, J.W.; Castedo, S.M.M.J.; De Jong, B.; Seruca, R.; Buist, J.; Schraffordt Koops, H.; Leeuw, J.B.. "Karyotyping and DNA flow cytometry of an orchidoblastoma". Cancer Genetics and Cytogenetics 36 1 (1988): 7-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024244063&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90069-6
  260. Castedo, S.M.M.J.; Seruca, R.; Oosterhuis, J.W.; De Jong, B.; Schraffordt Koops, H.; Leeuw, J.A.. "Cytogenetics of a case of osteosarcoma". Cancer Genetics and Cytogenetics 32 1 (1988): 149-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023884810&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90322-6
  261. Castedo, S.M.M.J.; De Jong, B.; Oosterhuis, J.W.; Seruca, R.; Buist, J.; Schraffordt Koops, H.. "Cytogenetic study of a combined germ cell tumor of the testis". Cancer Genetics and Cytogenetics 35 2 (1988): 159-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024204378&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90237-3
  262. Castedo, S.M.M.J.; Oosterhuis, J.W.; De Jong, B.; Seruca, R.; Dam, A.; Buist, J.; Schraffordt Koops, H.; Sleijfer Th., D.. "A residual mature teratoma with a more balanced karyotype than the primary testicular nonseminoma?". Cancer Genetics and Cytogenetics 32 1 (1988): 51-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023932663&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90311-1
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2016 - Current Influence of ECM components on cancer stem-like properties
Supervisor of Ana Margarida Moreira
 Molecular and Cellular Biotechnology Applied to Health Sciences (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2021/01/26 Diagnose cancer-causative E-cadherin missense mutations through molecular and morphological changes involved in cell extrusion
Supervisor of Soraia Melo
 Biomedicine (PhD)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2012 PhD Joana Figueiredo
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2012 PhD Giovanni Corso
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2007 - 2011 PhD Joana Caldeira Fernandes
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2006 - 2010 PhD Sérgia Velho
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2009 PhD Rita Mateus
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2009 PhD Joana Correia
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2003 - 2009 PhD Filipe Jacinto
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2000 - 2004 PhD Mafalda Pinto
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
1998 - 2002 PhD Carla Oliveira
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
1997 - 2001 PhD Beatriz Carvalho
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015 - 2015 Organizing Committee Member - XXIII Porto Cancer Meeting (2015 - 2015)
Congress (Member of the Organising Committee)
2007 - 2007 Organizing Committee Member - Reunião Anual SPGH (2007 - 2007)
Congress (Member of the Organising Committee)
2004 - 2004 Organizing Committee Member - XIII Porto Cancer Meeting (2004 - 2004)
Congress (Member of the Organising Committee)

Association member

Society Organization name Role
2012 - Current Member of Portuguese Association for Cancer Research - ASPIC
2007 - 2007 President of the Portuguese Human Genetics Society

Committee member

Activity description
Role 		Institution / Organization
2018 - 2019 Installing Committee Member of "Agência de Investigação Clínica e Inovação Biomédica"
Member
2008 - 2011 Scientific Committee Member of the Gulbenkian Programme in collaboration with Champalimaud Foundation for Advanced Medical Training.
Member

Consulting

Activity description Institution / Organization
2001 - Current Member of the Scientific Advisory Council of the American Association "No Stomach for Cancer".
2009 - 2013 Scientific Advisory Board Member of "Conselho Nacional de Ética para as Ciências da Vida", Assembleia da República Portuguesa Assembleia da República Portuguesa, Portugal
2009 - 2013 Member of the external Scientific Committee at the "Institute of Predictive and Personalized Medicine of Cancer, Universitat Autònoma de Barcelona - Campus of International Excellence/UAB-CIE Universitat Autònoma de Barcelona, Spain
2005 - 2008 Member of the Scientific Programme Committee, European Society of Human Genetics

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2009 - Current Lecturer of the Oncobiology Module of Doctoral Programme in Biomedicine Oncobiologia (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2007 - Current Lecturer of the Oncobiology Module of Doctoral Programme in Pathology and Molecular Genetics Oncobiologia (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - Current Lecturer of the Oncobiology Module of Doctoral Programme in Molecular and Oncology Medicine Oncobiologia (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2006 - Current Affiliated Professor Biological/Molecular mechanisms of cancer development and progession Universidade do Porto Faculdade de Medicina, Portugal
2004 - Current Lecturer of the Oncobiology Module of Msc Programme in Molecular and Oncology Medicine Oncobiologia Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - 2018 Lecturer of the Oncobiology Module of GABBA Doctoral Programme Oncobiologia (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2008 - 2015 Coordinator of the Oncobiology Module of GABBA Doctoral Programme Oncobiologia (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2011 - 2012 Coordinator of the Biomedicine and Basic Medicine panel of PhD and Postdoctoral Grants
Other
 Fundação para a Ciência e a Tecnologia
2008 - 2010 International Evaluator of European Projects within 7th Framework funding programme (FP7) and Marie Curie grants.
Evaluator
 European Commission, Belgium

Mentoring / Tutoring

Topic Student name
2006 - 2010 Ombudsperson at IPATIMUP Students and staff

Other jury / evaluation

Activity description Institution / Organization
2007 - 2017 Evaluator of PhD and Postdoctoral grants for the Portuguese Foundation for Science and Technology (FCT). Fundação para a Ciência e a Tecnologia, Portugal
Distinctions

Other distinction

2014 Medalha de Ouro de Mérito Cientifico
2009 Ordem do Infante D. Henrique
Palácio do Planalto, Brazil
2005 Estímulo à Excelência
2003 Prémio Labmed
2002 Prémio Labmed
2002 Benjamin Castelman Award
United States and Canadian Academy of Pathology, United States
2002 Primeiro Prémio Sociedade Portuguesa de Genética