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Flávia Sousa is a tenure-track Assistant Professor at Groningen Research Institute of Pharmacy, University of Groningen, Netherlands since 2024. She completed her MSc in Pharmaceutical Sciences in 2013 and obtained her PhD in Biomedical Sciences at ICBAS, University of Porto in 2019. Her PhD was developed at I3S (Porto, Portugal) in collaboration with INL (International Iberian Nanotechnology Laboratory, Braga, Portugal), Aalborg University (Aalborg, Denmark) and Northeastern University (Boston, USA). After finishing her PhD studies, Flávia Sousa did her first postdoctoral studies at Imperial College London followed by Marie Curie MINDED fellowship at IIT (Istituto Italiano di Tecnologia). In 2022, she began an independent Women in Science (WINS) research fellowship awarded by the NCCR for Bio-Inspired Materials. Her current research is focused on developing nanodelivery systems for biomolecules delivery (e.g. monoclonal antibodies, proteins, saRNA). In the past 5 years, she has authored over 40 publications, received 15 scientific awards from different countries, acquiring over 1700 citations and yielding a H-index of 22. Up to the present she taught more than 400h in the pharmaceutical technology, biotoxicology, nanomedicine, biotechnology and analytical chemistry field.
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Identification

Personal identification

Full name
Flávia Cristina Moreira de Sousa

Citation names

  • Sousa, Flávia

Author identifiers

Ciência ID
AF15-BA82-CFA6
ORCID iD
0000-0001-6587-6175
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=lotfTtEAAAAJ
Researcher Id
AAY-1208-2020

Addresses

  • Via Moreno 30, 16163 , Genova, Genova, Italy (Professional)
  • Rua Manuel da Silva Araujo 216 1.3., 4450-565, Leça da Palmeira, Matosinhos, Portugal (Personal)
  • Via Guirardelli 2, cottage, 16167, Nervi, Genova, Italy (Personal)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Italian Elementary (A2) Elementary (A2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2015/10/01 - 2019/04/05
Concluded
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"“Study of biophysical interactions and antibody bioactivity of bevacizumab encapsulated into nanoparticles towards its controlled release”" (THESIS/DISSERTATION)
2013/09/01
Concluded
 Ciências Farmacêuticas (Mestrado)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
"n/a" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2022/07 - 2024/06 Auxiliary Researcher (Research) National Center of Competence in Research Bio-Inspired Materials, Switzerland
Adolphe Merkle Institute, Switzerland
2021/02/01 - 2022/06 Contracted Researcher (Research) EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Belgium
Istituto Italiano di Tecnologia, Italy
2019/05/01 - 2022/06 Visiting Researcher (Research) Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
2020/08/01 - 2021/01/31 Contracted Researcher (Research) Stemmatters Biotecnologia e Medicina Regenerativa SA, Portugal
2020/02/01 - 2020/07/31 Contracted Researcher (Research) Imperial College London Department of Materials, United Kingdom
2019/05/16 - 2020/01/31 Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/05/01 - 2019 Visiting Researcher (Research) International Iberian Nanotechnology Laboratory, Portugal
2015/10/01 - 2019 Visiting Researcher (Research) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2015/10/01 - 2019 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/02/01 - 2018/07/31 Visiting Researcher (Research) Northeastern University Bouvé College of Health Sciences, United States
2016/08/01 - 2017/04/01 Visiting Researcher (Research) Aalborg Universitet, Denmark

Teaching in Higher Education

Category
Host institution 		Employer
2024/04 - Current Assistant Professor (University Teacher) Rijksuniversiteit Groningen Groningen Research Institute of Pharmacy, Netherlands
Rijksuniversiteit Groningen Groningen Research Institute of Pharmacy, Netherlands
2018/09 - 2022/06 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal

Positions / Appointments

Category
Host institution 		Employer
2019/09 - 2021/06 Trainee Representative at the Board of the CRS Focus Group in Nanomedicine and Nanoscale Delivery Controlled Release Society, United States
2018/05/01 - 2020 Young Scientific Committee Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS), Spain
2018/06 - 2019/06 First vowel Portuguese American Postgraduate Society (PAPS), United States
2018/09/01 - 2019/04/05 Representative of i3S PhD students Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Others

Category
Host institution 		Employer
2019/10 - Current Member European Association For Cancer Research, United Kingdom
2017/01 - Current Member Controlled Release Society, United States
2016/05 - 2019/04 Invited Researcher International Iberian Nanotechnology Laboratory, Portugal
2018/02 - 2018/06 Fulbrighter Researcher Northeastern University Bouvé College of Health Sciences School of Pharmacy, United States
2016/08 - 2017/04 Invited Researcher Aalborg Universitet, Denmark
Projects

Grant

Designation Funders
2021/02/01 - 2022/06 Discovering how to reprogram immunologically the brain cancer microenvironment
Marie-Curie Fellowship
Researcher
Istituto Italiano di Tecnologia, Italy
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded
2019/05 - 2020/01/31 RESTORE - Osteoarticular tissues regeneration
H2020-NMBP-TR-IND-2018-814558-2
Post-doc
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing

Contract

Designation Funders
2022/07 - 2024/06 Development of immunostimulatory nanoparticles for brain cancer treatment
Grant number 205603
Principal investigator
National Center of Competence in Research Bio-Inspired Materials, Switzerland
 National Center of Competence in Research Bio-Inspired Materials
Ongoing
2020/08/01 - 2021/01/31 Novel injectable biosensor for continuous remote monitoring of cancer patients at high-risk of relapse
NORTE-01-0247-FEDER-045914
Researcher
2018 - 2021 PANCREASMIMETIC - Establishment of a multifunctional stimuli-responsive pancreas mimetic
PTDC/CTM-CER/30046/2017
Researcher
Fundação para a Ciência e a Tecnologia, Portugal
Ongoing
2020/02/01 - 2020/07/31 Injectable Crosslinked Long-Acting Formulations
INV-004356
Researcher
Imperial College London Department of Materials, United Kingdom
 Bill & Melinda Gates Foundation
Ongoing

Other

Designation Funders
2019 - Current Biological assessment of debris from oral implants
IMPLDEBRIS-PL-3RL-IINFACTS-2019
Researcher
Instituto Universitário de Ciências da Saúde, Portugal
2016 - 2017/03 Development of biocomposites fibrous scaffolds as topical 5-fluorouracil carriers for inhibiting hypertrophic scar
ElectrospunnScar-CESPU-2016
Researcher
Instituto Universitário de Ciências da Saúde, Portugal
Concluded
Outputs

Publications

Book chapter
  1. "Implantable and long-lasting drug delivery systems for cancer treatment". 129-162. Elsevier, 2022.
    10.1016/b978-0-12-821749-8.00011-2
  2. Moura, R.P.; Sousa, F.; Almeida, A.; Pinto, S.; Sarmento, B.. "Theranostic biomaterials for regulation of the blood-brain barrier". 303-319. 2019.
  3. Sousa, Flávia; Moura, Rui P.; Moreira, Elias; Martins, Cláudia; Sarmento, Bruno. "Therapeutic Monoclonal Antibodies Delivery for the Glioblastoma Treatment". In Advances in Protein Chemistry and Structural Biology, 61-80. Elsevier, 2018.
    10.1016/bs.apcsb.2018.03.001
  4. Fonte, Pedro; Sousa, Flávia; Sarmento, Bruno. "Polyester-Based Nanoparticles for Delivery of Therapeutic Proteins". In Recombinant Glycoprotein Production, 255-274. Springer New York, 2017.
    Published • 10.1007/978-1-4939-7312-5_21
  5. Sousa, Flávia; Fonte, Pedro; Cruz, Andreia; Kennedy, Patrick J.; Pinto, Inês Mendes; Sarmento, Bruno. "Polyester-Based Nanoparticles for the Encapsulation of Monoclonal Antibodies". In Recombinant Glycoprotein Production, 239-253. Springer New York, 2017.
    10.1007/978-1-4939-7312-5_20
  6. Sousa, Flávia; Castro, Pedro. "Cell-based in vitro models for nasal permeability studies". In Concepts and Models for Drug Permeability Studies, 83-100. Elsevier, 2016.
    10.1016/b978-0-08-100094-6.00006-7
  7. Sousa, F.; Castro, P.. "Cell-based in vitro models for nasal permeability studies". 2016.
  8. Sousa, F.; Fonte, P.; Sarmento, B.; Sousa, Flávia. "Effect of lipid matrix on structure and stability of protein-loaded solid lipid nanoparticles and nanostructured lipid carriers". 2015.
Conference poster
  1. Sousa, Flávia. "Enhanced anti-angiogenic effect of bevacizumab in PLGA nanoparticles on glioblastoma treatment upon intranasal administration". 2019.
  2. Sousa, Flávia. "An improvement of anti-angiogenic therapy achieved by bevacizumab delivery through PLGA nanocarriers". Paper presented in 2018 CRS Annual Meeting & Exposition New York, 2018.
  3. Sousa, Flávia. "tudy of biophysical interactions and bevacizumab bioactivity encapsulated into nanoparticles towards its controlled release". Paper presented in i3s Annual Meeting 2017, 2017.
  4. Sousa, Flávia. "Stability and bioactivity study of bevacizumab-loaded PLGA nanoparticles towards its controlled release". Paper presented in 43rd International Conference on Micro and NanoEngineering, 2017.
  5. Sousa, Flávia. "Stability and bioactivity study of bevacizumab-loaded PLGA nanoparticles towards its controlled release". Paper presented in 6th edition of the Advanced Summer School, 2017.
  6. Sousa, Flávia. "A new paradigm for antiangiogenic therapy through controlled release of bevacizumab". Paper presented in First SPLC-CRS Young Scientist Meeting, 2017.
Journal article
  1. Fatima Hameedat; Bárbara B. Mendes; Conniot, João; Leonardo Filippo; Marcus Chorilli; Avi Schroeder; Conde, João; Sousa, Flávia. Corresponding author: Sousa, Flávia. "Engineering nanomaterials for glioblastoma nanovaccination". Nature Reviews Materials (2024):
  2. Sousa, Flávia; Lee, Henry; Almeida, Mauro; Bazzoni, Amelie; Rothen-Rutishauser, Barbara; Petri-Fink, Alke. "Immunostimulatory nanoparticles delivering cytokines as a novel cancer nanoadjuvant to empower glioblastoma immunotherapy". Drug Delivery and Translational Research (2023): http://dx.doi.org/10.1007/s13346-023-01509-2.
    10.1007/s13346-023-01509-2
  3. Flávia Sousa. "Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions". Materials Today Bio (2022): http://dx.doi.org/10.1016/j.mtbio.2022.100417.
    10.1016/j.mtbio.2022.100417
  4. Flávia Sousa. "Brain-Targeted Drug Delivery". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091835.
    10.3390/pharmaceutics14091835
  5. "Intratumoral VEGF nanotrapper reduces gliobastoma vascularization and tumor cell mass". Journal of Controlled Release 339 (2021): 381-390. http://dx.doi.org/10.1016/j.jconrel.2021.09.031.
    10.1016/j.jconrel.2021.09.031
  6. "Structural and functional analysis of broad pH and thermal stable protease from Penicillium aurantiogriseum URM 4622". Preparative Biochemistry & Biotechnology (2021): 1-12. http://dx.doi.org/10.1080/10826068.2021.1972429.
    10.1080/10826068.2021.1972429
  7. "In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells". European Journal of Pharmaceutics and Biopharmaceutics 163 (2021): 120-126. http://dx.doi.org/10.1016/j.ejpb.2021.04.002.
    10.1016/j.ejpb.2021.04.002
  8. Finbloom, Joel A.; Sousa, Flávia; Stevens, Molly M.; Desai, Tejal A.. "Engineering the drug carrier biointerface to overcome biological barriers to drug delivery". Advanced Drug Delivery Reviews 167 (2020): 89-108. http://dx.doi.org/10.1016/j.addr.2020.06.007.
    10.1016/j.addr.2020.06.007
  9. Jaradat, Abdolelah; Macedo, Maria Helena; Sousa, Flávia; Arkill, Kenton; Alexander, Cameron; Aylott, Jonathan; Sarmento, Bruno. "Prediction of the enhanced insulin absorption across a triple co-cultured intestinal model using mucus penetrating PLGA nanoparticles". International Journal of Pharmaceutics 585 (2020): 119516. http://dx.doi.org/10.1016/j.ijpharm.2020.119516.
    10.1016/j.ijpharm.2020.119516
  10. Qin, Menglu; Jin, Jing; Saiding, Qimanguli; Xiang, Yi; Wang, Yong; Sousa, Flávia; Sarmento, Bruno; Cui, Wenguo; Chen, Xinliang. "In situ inflammatory-regulated drug-loaded hydrogels for promoting pelvic floor repair". Journal of Controlled Release 322 (2020): 375-389. http://dx.doi.org/10.1016/j.jconrel.2020.03.030.
    10.1016/j.jconrel.2020.03.030
  11. Martins, João Pedro; das Neves, José; de la Fuente, María; Celia, Christian; Florindo, Helena; Günday-Türeli, Nazende; Popat, Amirali; et al. "The solid progress of nanomedicine". Drug Delivery and Translational Research 10 3 (2020): 726-729. http://dx.doi.org/10.1007/s13346-020-00743-2.
    10.1007/s13346-020-00743-2
  12. Pacheco, Catarina; Sousa, Flávia; Sarmento, Bruno. "Chitosan-based nanomedicine for brain delivery: Where are we heading?". Reactive and Functional Polymers 146 (2020): 104430. http://dx.doi.org/10.1016/j.reactfunctpolym.2019.104430.
    10.1016/j.reactfunctpolym.2019.104430
  13. Baião, Ana; Sousa, Flávia; Oliveira, Ana Vanessa; Oliveira, Carla; Sarmento, Bruno. "Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting the CD44v6 receptor in colon cancer cells". Biomaterials Science 8 13 (2020): 3720-3729. http://dx.doi.org/10.1039/d0bm00556h.
    10.1039/d0bm00556h
  14. Ana Baião; Flávia Sousa; Ana Vanessa Oliveira; Carla Oliveira; Bruno Sarmento. "Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting the CD44v6 receptor in colon cancer cells". Biomaterials Science (2020): https://doi.org/10.1039/D0BM00556H.
    10.1039/D0BM00556H
  15. Yang, Jielai; Wang, Fei; Lu, Yong; Qi, Jin; Deng, Lianfu; Sousa, Flávia; Sarmento, Bruno; Xu, Xiangyang; Cui, Wenguo. "Recent advance of erythrocyte-mimicking nanovehicles: From bench to bedside". Journal of Controlled Release 314 (2019): 81-91. http://dx.doi.org/10.1016/j.jconrel.2019.10.032.
    10.1016/j.jconrel.2019.10.032
  16. Moura, Rui Pedro; Martins, Cláudia; Pinto, Soraia; Sousa, Flávia; Sarmento, Bruno. "Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology". Expert Opinion on Drug Delivery 16 3 (2019): 271-285. http://dx.doi.org/10.1080/17425247.2019.1583205.
    10.1080/17425247.2019.1583205
  17. Sousa, F.; Dhaliwal, H.K.; Gattacceca, F.; Sarmento, B.; Amiji, M.M.. "Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles". Journal of Controlled Release 309 (2019): 37-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069705484&partnerID=MN8TOARS.
    10.1016/j.jconrel.2019.07.033
  18. Yang, J.; Wang, F.; Lu, Y.; Qi, J.; Deng, L.; Sousa, F.; Sarmento, B.; Xu, X.; Cui, W.. "Recent advance of erythrocyte-mimicking nanovehicles: From bench to bedside". Journal of Controlled Release 314 (2019): 81-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074027469&partnerID=MN8TOARS.
    10.1016/j.jconrel.2019.10.032
  19. Ferreira, Natália Noronha; Caetano, Bruno Leonardo; Boni, Fernanda Isadora; Sousa, Flávia; Magnani, Marina; Sarmento, Bruno; Ferreira Cury, Beatriz Stringhetti; Gremião, Maria Palmira Daflon. "Alginate-Based Delivery Systems For Bevacizumab Local Therapy: In Vitro Stuctural Features And Release Properties". Journal of Pharmaceutical Sciences (2018): http://dx.doi.org/10.1016/j.xphs.2018.11.038.
    Published • 10.1016/j.xphs.2018.11.038
  20. Kennedy, Patrick J.; Sousa, Flavia; Ferreira, Daniel; Pereira, Carla; Nestor, Marika; Oliveira, Carla; Granja, Pedro L.; Sarmento, Bruno. "Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6". Acta Biomaterialia 81 (2018): 208-218. http://dx.doi.org/10.1016/j.actbio.2018.09.043.
    Published • 10.1016/j.actbio.2018.09.043
  21. Pereira, Inês; Sousa, Flávia; Kennedy, Patrick; Sarmento, Bruno. "Carcinoembryonic antigen-targeted nanoparticles potentiate the delivery of anticancer drugs to colorectal cancer cells". International Journal of Pharmaceutics 549 1-2 (2018): 397-403. http://dx.doi.org/10.1016/j.ijpharm.2018.08.016.
    Published • 10.1016/j.ijpharm.2018.08.016
  22. da Silva, Osmar Soares; Silva, Jônatas de Carvalho; de Almeida, Elizane Melo; Sousa, Flávia; Gonçalves, Odete Sofia Lopes; Sarmento, Bruno; Neves-Petersen, Maria Teresa; Porto, Tatiana Souza. "Biophysical, photochemical and biochemical characterization of a protease from Aspergillus tamarii URM4634". International Journal of Biological Macromolecules 118 (2018): 1655-1666. http://dx.doi.org/10.1016/j.ijbiomac.2018.07.004.
    Published • 10.1016/j.ijbiomac.2018.07.004
  23. Sousa, Flávia; Cruz, Andrea; Pinto, Inês Mendes; Sarmento, Bruno. "Nanoparticles provide long-term stability of bevacizumab preserving its antiangiogenic activity". Acta Biomaterialia 78 (2018): 285-295. http://dx.doi.org/10.1016/j.actbio.2018.07.040.
    Published • 10.1016/j.actbio.2018.07.040
  24. Castro, Pedro M.; Sousa, Flávia; Magalhães, Rui; Ruiz-Henestrosa, Victor Manuel Pizones; Pilosof, Ana M.R.; Madureira, Ana Raquel; Sarmento, Bruno; Pintado, Manuela E.. "Incorporation of beads into oral films for buccal and oral delivery of bioactive molecules". Carbohydrate Polymers 194 (2018): 411-421. http://dx.doi.org/10.1016/j.carbpol.2018.04.032.
    10.1016/j.carbpol.2018.04.032
  25. Sousa, Flávia. "Extraction and characterisation of cellulose nanocrystals from pineapple peel". International Journal of Food Studies (2018): 24-33. http://dx.doi.org/10.7455/ijfs/7.1.2018.a3.
    Published • 10.7455/ijfs/7.1.2018.a3
  26. Martins, Cláudia; Sousa, Flávia; Araújo, Francisca; Sarmento, Bruno. "Poly(Lactic-co-Glycolic) Acid: Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications (Adv. Healthcare Mater. 1/2018)". Advanced Healthcare Materials 7 1 (2018): 1870002. http://dx.doi.org/10.1002/adhm.201870002.
    Published • 10.1002/adhm.201870002
  27. Sgorla, Débora; Lechanteur, Anna; Almeida, Andreia; Sousa, Flávia; Melo, Eduardo; Bunhak, Élcio; Mainardes, Rubiana; et al. "Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery". Expert Opinion on Drug Delivery 15 3 (2017): 213-222. http://dx.doi.org/10.1080/17425247.2018.1420050.
    Published • 10.1080/17425247.2018.1420050
  28. Flávia Sousa; Andrea Cruz; Pedro Fonte; Inês Mendes Pinto; Maria Teresa Neves-Petersen; Bruno Sarmento. "A new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticles". Scientific Reports 7 1 (2017): https://doi.org/10.1038%2Fs41598-017-03959-4.
    10.1038/s41598-017-03959-4
  29. Martins, Cláudia; Sousa, Flávia; Araújo, Francisca; Sarmento, Bruno. "Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications". Advanced Healthcare Materials 7 1 (2017): 1701035. http://dx.doi.org/10.1002/adhm.201701035.
    10.1002/adhm.201701035
  30. Sousa, Flávia. "Biophysical study of bevacizumab structure and bioactivity under thermal and pH-stresses". European Journal of Pharmaceutical Sciences (2017): https://doi.org/10.1016/j.ejps.2017.05.019.
    10.1016/j.ejps.2017.05.019
  31. Sousa, Flávia. "Development and validation of a rapid reversed-phase HPLC method for the quantification of monoclonal antibody bevacizumab from polyester-based nanoparticles". Journal of Pharmaceutical and Biomedical Analysis (2017):
    10.1016/j.jpba.2017.05.015
  32. Sousa, Flávia; Castro, Pedro; Fonte, Pedro; Kennedy, Patrick J.; Neves-Petersen, Maria Teresa; Sarmento, Bruno. "Nanoparticles for the delivery of therapeutic antibodies: Dogma or promising strategy?". Expert Opinion on Drug Delivery 14 10 (2016): 1163-1176. http://dx.doi.org/10.1080/17425247.2017.1273345.
    Published • 10.1080/17425247.2017.1273345
  33. Sousa, Flávia. "Oral strips as breakthrough tools for oral delivery of proteins/peptides". (2015):
    10.1016/j.jconrel.2015.05.258
  34. Sousa, F.; Castro, P.; Fonte, P.; Sarmento, B.; Sousa, Flávia. "How to overcome the limitations of current insulin administration with new non-invasive delivery systems". Therapeutic Delivery 6 1 (2015): 83-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920747181&partnerID=MN8TOARS.
    10.4155/tde.14.82
  35. Sousa, Flávia. "A stability study perspective of the effect of freeze-drying using cryoprotectants on the structure of insulin loaded into PLGA nanoparticles". Biomacromolecules (2014): http://www.ncbi.nlm.nih.gov/pubmed/25180545.
    10.1021/bm5010383
Thesis / Dissertation
  1. Sousa, Flávia. "Study of biophysical interactions and antibody bioactivity of bevacizumab encapsulated into nanoparticles towards its controlled release". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2019. https://sigarra.up.pt/icbas/pt/noticias_geral.ver_noticia?p_nr=29887.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07/20 Enhanced anti-angiogenic effect of bevacizumab in PLGA nanoparticles on glioblastoma treatment upon intranasal administration CRS
(Valência, Spain)
2019/06/18 Enhanced anti-angiogenic effect of bevacizumab in PLGA nanoparticles on glioblastoma treatment upon intranasal administration Nanotoday conference
2019/01/23 Nanoencapsulated Bevacizumab Inhibits Glioblastoma Vascularization via Intratumoral VEGF Trapping SPLC-CRS
2017 A new paradigm for antiangiogenic therapy through controlled release of bevacizumab First SPLC-CRS Young Scientist Meeting
(Spain)
2017 Stability and bioactivity study of bevacizumab-loaded PLGA nanoparticles towards its controlled release 43rd International Conference on Micro and Nanoengineering
(Portugal)
2017 Study of biophysical interactions and bevacizumab bioactivity encapsulated into nanoparticles towards its controlled release i3s annual meeting
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/10/01 - Current Co-targeting of glycolytic cancer metabolism and angiogenesis through polymeric nanoparticles for glioblastoma therapeutics
Supervisor
Instituto Universitário de Ciências da Saúde, Portugal
2019/05 - 2019/12 Multifunctional nanomedicine for the intracellular delivery of an antibody to CD44v6 expressing cancer cells
Co-supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/04/01 - 2019/07/01 In vitro methods of biopharmaceutical evaluation in the blood- brain barrier.
Co-supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/01 - 2017/09 Carcinoembryonic antigen targeted polymeric nanoparticles for drug delivery
Co-supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/10/01 - Current Young Scientist organizing committee of the 2nd PhD day, “PhD countdown- a time for science”, I3s, University of Porto, Portugal (2019/09/26)
2018/06/23 - Current Young Scientist organizing committee of the 2nd SPLC-CRS Young Scientist Meeting, Santiago de Compostela, Spain (2019/01/23)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/09/18 DESENVOLVIMENTO E VALIDAÇÃO DE UM MÉTODO ANALÍTICO PARA A DETERMINAÇÃO DE DIFENILAMINA EM AMOSTRAS DE PÓLVORA
(Thesis) Main arguer
 Andreia Filipa Pessoa Vieira (Other)
Instituto Universitário de Ciências da Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/02/22 - Current Tecnologia Farmacêutica Mestrado Integrado em Ciências Farmacêuticas (Mestrado integrado) Instituto Universitário de Ciências da Saúde, Portugal
2018/09 - Current Analytical Methods Biomedical Sciences, Pharmaceutical Sciences Instituto Universitário de Ciências da Saúde, Portugal
2018/09 - Current Food Biotechnology Ciências da Nutrição (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2018/09 - Current Bromatology Ciências da Nutrição (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
Distinctions

Award

2023 72nd Lindau Nobel Laureate meeting participant
2022 Pharmaceutics Travel Award
2019 Best oral presentation at SPLC-Controlled Release Society
2019 Exceptional Young Scientist Award
2019 FLAD grant
Fundação Luso-Americana, Portugal
2019 Travel Award
European Cooperation in Science and Technology, Belgium
2018 Kinam Park 2018 Student Travel Awards to the Controlled Release Society Annual Meeting
2018 COST Action CA17140 Nanomedicine - from the bench to the bedside
European Cooperation in Science and Technology, Belgium
2017 Fulbright grant

Title

2023 Female Science Talent by Falling Walls Foundation
2023 MIT Innovators Under 35 Europe
2021 Marie-Curie MINDED Fellow
Istituto Italiano di Tecnologia, Italy

Other distinction

2023 TEDx talk at the University of Twente, Netherlands