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Pierre Falson (PF) is a CNRS (Centre National de la Recherche Scientifique) 1st Class Research Director, specialist of membrane proteins involved in translocation processes. Sine 2016 PF leads the Drug Resistance & Membrane Proteins group in the CNRS - Lyon 1 University shared laboratory at the IBCP (Institut de Biologie et Chime des Protéines). PF studied the yeast F1-ATPase during his PhD (Lyon 1984-88) followed by a UE-Post-doc in Belgium (Louvain-la-Neuve 1988-89) (>10 publications). In 1991 was awarded by the Maurice Nicloux Award received from French society of Biochemistry and Molecular Biology, Lyon for his contribution on the F1-ATPase study. PF was recruited at the CNRS as Research Officer in 1989 and joined the CEA (Commissariat à l’Energie Atomique) where he studied the rabbit Calcium transporting ATPase and the human red cell anion exchanger (>20 publications, PNAS 1996). PF joined the IBCP in 2006 where he focused on the function and structure of multidrug ABC exporters, the setup of inhibitors and the stabilization of membrane proteins in detergents solution for structural purposes (>50 publications, 9 patents 3 licenses, PNAS 2013, Angewandte Chemie Int 2018). In 2011 PF co-founded CALIXAR, a start-up devoted to the extraction and stabilization of membrane proteins and was awarded by the “National competition of innovative start-ups” together with the Innovation and Transfer Technology prize from the University of Lyon. So far, Pierre Guy Falson. Published 114 articles in journals and 9 patents, with 3 licenses.
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Identification

Personal identification

Full name
Pierre Guy Falson

Citation names

  • Falson, Pierre

Author identifiers

Ciência ID
AE1E-5F7F-0454
ORCID iD
0000-0002-9760-4577
Affiliation

Science

Category
Host institution 		Employer
2013 - Current Coordinating Researcher (Research) Institut de Biologie et Chimie des Protéines, France
Projects

Grant

Designation Funders
2019/10 - 2023/04 Dissecting the molecular mechanism of an antibiotic efflux pump – BIOTIFLUX
ANR-19-CE11-0023
 Agence nationale de la recherche
2018/12 - 2021/12 Molecular stabilizers of membrane proteins for structural studies in solution – CLAMP2
ANR-18-CE11-0002
 Agence nationale de la recherche
2017/10 - 2020/09 Production of recombinant membrane proteins embedded in heterologous caveolae
ANR-17-CE11-0015-03
 Agence nationale de la recherche
2014/10 - 2017/08 Zooming in on the conformational details of a membrane efflux pump
ANR-14-CE09-0024
 Agence nationale de la recherche
2013/10 - 2017/03 Stabilizing detergents through a salt-bridges network for studying and crystallizing in solution membrane proteins in a functional form. Application to multidrug ABC efflux pumps.
ANR-13-BSV5-0001
 Agence nationale de la recherche
2010/10 - 2014/09 Supramolecular additives for crystallization of multidrug resistance ABC transporters
ANR-PIRIBio-AddX
 Agence nationale de la recherche
2011/06 - 2013/05 Innovative extraction to crystallization technology of functional membrane proteins in solution
ANR-10-EMMA-0049
 Agence nationale de la recherche
2007/10 - 2010/09 Design of calix[n]arenic detergents for structural and functional studies of ABC transporters
ANR-06-PCVI-0019-01
 Agence nationale de la recherche
Outputs

Publications

Journal article
  1. Falson, Pierre. "Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters of Candida albicans.". Journal of fungi (Basel, Switzerland) (2021): https://doi.org/10.3390/jof7020068.
    10.3390/jof7020068
  2. Falson, Pierre. "ABCG: a new fold of ABC exporters and a whole new bag of riddles!". Advances in protein chemistry and structural biology (2020): https://doi.org/10.1016/bs.apcsb.2020.09.006.
    10.1016/bs.apcsb.2020.09.006
  3. Falson, Pierre. "Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2.". European journal of medicinal chemistry (2020): https://doi.org/10.1016/j.ejmech.2020.113017.
    10.1016/j.ejmech.2020.113017
  4. Falson, Pierre. "Chromones bearing amino acid residues: Easily accessible and potent inhibitors of the breast cancer resistance protein ABCG2.". European journal of medicinal chemistry (2020): https://doi.org/10.1016/j.ejmech.2020.112503.
    10.1016/j.ejmech.2020.112503
  5. Falson, Pierre. "Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1.". Scientific reports (2020): https://europepmc.org/articles/PMC7203140.
    10.1038/s41598-020-64400-x
  6. Szilárd Tóth; Áron Szepesi; Viet-Khoa Tran-Nguyen; Balázs Sarkadi; Katalin Német; Pierre Falson; Attilio Di Pietro; Gergely Szakács; Ahcène Boumendjel. "Synthesis and Anticancer Cytotoxicity of Azaaurones Overcoming Multidrug Resistance". Molecules (2020): https://www.mdpi.com/1420-3049/25/3/764.
    10.3390/molecules25030764
  7. Falson, Pierre. "Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps.". Biochimica et biophysica acta. Biomembranes (2019): https://doi.org/10.1016/j.bbamem.2019.183131.
    10.1016/j.bbamem.2019.183131
  8. Falson, Pierre. "Optimization of the chromone scaffold through QSAR and docking studies: Identification of potent inhibitors of ABCG2.". European journal of medicinal chemistry (2019): https://doi.org/10.1016/j.ejmech.2019.111772.
    10.1016/j.ejmech.2019.111772
  9. Falson, Pierre. "PDR-like ABC systems in pathogenic fungi.". Research in microbiology (2019): https://doi.org/10.1016/j.resmic.2019.09.002.
    10.1016/j.resmic.2019.09.002
  10. Falson, Pierre. "Polymer "ruthenium-cyclopentadienyl" conjugates - New emerging anti-cancer drugs.". European journal of medicinal chemistry (2019): https://doi.org/10.1016/j.ejmech.2019.02.061.
    10.1016/j.ejmech.2019.02.061
  11. Falson, Pierre. "Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand.". European journal of medicinal chemistry (2018): https://doi.org/10.1016/j.ejmech.2018.12.022.
    10.1016/j.ejmech.2018.12.022
  12. Falson, Pierre. "Externalized Keratin 8: A Target at the Interface of Microenvironment and Intracellular Signaling in Colorectal Cancer Cells.". Cancers (2018): http://europepmc.org/articles/PMC6266717.
    10.3390/cancers10110452
  13. Falson, Pierre. "5-Oxo-hexahydroquinoline derivatives as modulators of P-gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells.". Toxicology and applied pharmacology (2018): https://doi.org/10.1016/j.taap.2018.10.025.
    10.1016/j.taap.2018.10.025
  14. Nim S; Baghel P; Tran-Nguyen VK; Peres B; Nguyen KA; Pietro AD; Falson P; Prasad R; Boumendjel A. "Make azoles active again: chalcones as potent reversal agents of transporters-mediated resistance in Candida albicans.". Future medicinal chemistry (2018): http://europepmc.org/abstract/med/30043631.
    10.4155/fmc-2018-0081
  15. Robert X; Kassis-Sahyoun J; Ceres N; Martin J; Sawaya MR; Read RJ; Gouet P; Falson P; Chaptal V. "Au courant computation of the PDB to audit diffraction anisotropy of soluble and membrane proteins.". Data in brief (2018): http://europepmc.org/abstract/med/30225276.
    10.1016/j.dib.2018.05.072
  16. Braun F; Bertoletti N; Möller G; Adamski J; Frotscher M; Guragossian N; Madeira Gírio PA; et al. "Structure-based design and profiling of novel 17ß-HSD14 inhibitors.". European journal of medicinal chemistry (2018): http://europepmc.org/abstract/med/29859505.
    10.1016/j.ejmech.2018.05.029
  17. Comsa E; Nguyen KA; Loghin F; Boumendjel A; Peuchmaur M; Andrieu T; Falson P. "Ovarian cancer cells cisplatin sensitization agents selected by mass cytometry target ABCC2 inhibition.". Future medicinal chemistry (2018): http://europepmc.org/abstract/med/29848100.
    10.4155/fmc-2017-0308
  18. Côrte-Real L; Teixeira RG; Gírio P; Comsa E; Moreno A; Nasr R; Baubichon-Cortay H; et al. "Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential.". Inorganic chemistry (2018): http://europepmc.org/abstract/med/29611696.
    10.1021/acs.inorgchem.8b00358
  19. Ferreira RJ; Baptista R; Moreno A; Madeira PG; Khonkarn R; Baubichon-Cortay H; Dos Santos DJ; Falson P; Ferreira MU. "Optimizing the flavanone core toward new selective nitrogen-containing modulators of ABC transporters.". Future medicinal chemistry (2018): http://europepmc.org/abstract/med/29570361.
    10.4155/fmc-2017-0228
  20. Banerjee A; Shah AH; Redhu AK; Moreno A; Falson P; Prasad R. "W1038 near D-loop of NBD2 is a focal point for inter-domain communication in multidrug transporter Cdr1 of Candida albicans.". Biochimica et biophysica acta. Biomembranes (2018): http://europepmc.org/abstract/med/29410026.
    10.1016/j.bbamem.2018.01.022
  21. Nguyen KA; Peuchmaur M; Magnard S; Haudecoeur R; Boyère C; Mounien S; Benammar I; et al. "Glycosyl-Substituted Dicarboxylates as Detergents for the Extraction, Overstabilization, and Crystallization of Membrane Proteins.". Angewandte Chemie (International ed. in English) (2018): http://europepmc.org/abstract/med/29377441.
    10.1002/anie.201713395
  22. Redhu AK; Banerjee A; Shah AH; Moreno A; Rawal MK; Nair R; Falson P; Prasad R. "Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter.". Journal of molecular biology (2018): http://europepmc.org/abstract/med/29341887.
    10.1016/j.jmb.2018.01.005
  23. Paterna A; Khonkarn R; Mulhovo S; Moreno A; Madeira Girio P; Baubichon-Cortay H; Falson P; Ferreira MU. "Monoterpene indole alkaloid azine derivatives as MDR reversal agents.". Bioorganic & medicinal chemistry (2017): http://europepmc.org/abstract/med/29233614.
    10.1016/j.bmc.2017.11.052
  24. Robert X; Kassis-Sahyoun J; Ceres N; Martin J; Sawaya MR; Read RJ; Gouet P; Falson P; Chaptal V. "X-ray diffraction reveals the intrinsic difference in the physical properties of membrane and soluble proteins.". Scientific reports (2017): http://europepmc.org/abstract/med/29208950.
    10.1038/s41598-017-17216-1
  25. Lacabanne D; Lends A; Danis C; Kunert B; Fogeron ML; Jirasko V; Chuilon C; et al. "Gradient reconstitution of membrane proteins for solid-state NMR studies.". Journal of biomolecular NMR (2017): http://europepmc.org/abstract/med/28900789.
    10.1007/s10858-017-0135-4
  26. Gilson P; Josa-Prado F; Beauvineau C; Naud-Martin D; Vanwonterghem L; Mahuteau-Betzer F; Moreno A; et al. "Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties.". Scientific reports (2017): http://europepmc.org/abstract/med/28860487.
    10.1038/s41598-017-09491-9
  27. Baghel P; Rawal MK; Khan MF; Sen S; Siddiqui MH; Chaptal V; Falson P; Prasad R. "Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport.". Biochimica et biophysica acta. Biomembranes (2017): http://europepmc.org/abstract/med/28559186.
    10.1016/j.bbamem.2017.05.011
  28. Geillon F; Gondcaille C; Raas Q; Dias AMM; Pecqueur D; Truntzer C; Lucchi G; et al. "Peroxisomal ATP-binding cassette transporters form mainly tetramers.". The Journal of biological chemistry (2017): http://europepmc.org/abstract/med/28258215.
    10.1074/jbc.M116.772806
  29. Chaptal V; Delolme F; Kilburg A; Magnard S; Montigny C; Picard M; Prier C; et al. "Quantification of Detergents Complexed with Membrane Proteins.". Scientific reports (2017): http://europepmc.org/abstract/med/28176812.
    10.1038/srep41751
  30. Lorendeau D; Dury L; Nasr R; Boumendjel A; Teodori E; Gutschow M; Falson P; Di Pietro A; Baubichon-Cortay H. "MRP1-dependent Collateral Sensitivity of Multidrug-resistant Cancer Cells: Identifying Selective Modulators Inducing Cellular Glutathione Depletion.". Current medicinal chemistry (2017): http://europepmc.org/abstract/med/27855620.
    10.2174/0929867324666161118130238
  31. Tran-Nguyen VK; Prasad R; Falson P; Boumendjel A. "Modulators of the Efflux Pump Cdr1p of Candida albicans: Mechanisms of Action and Chemical Features.". Current medicinal chemistry (2017): http://europepmc.org/abstract/med/28545374.
    10.2174/0929867324666170523102244
  32. Dury L; Nasr R; Lorendeau D; Comsa E; Wong I; Zhu X; Chan KF; et al. "Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.". Biochemical pharmacology (2016): http://europepmc.org/abstract/med/27984000.
    10.1016/j.bcp.2016.10.013
  33. Nim S; Lobato LG; Moreno A; Chaptal V; Rawal MK; Falson P; Prasad R. "Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.". Biochimica et biophysica acta (2016): http://europepmc.org/abstract/med/27569110.
    10.1016/j.bbamem.2016.08.011
  34. Redhu AK; Khandelwal NK; Banerjee A; Moreno A; Falson P; Prasad R. "pHluorin enables insights into the transport mechanism of antiporter Mdr1: R215 is critical for drug/H+ antiport.". The Biochemical journal (2016): http://europepmc.org/abstract/med/27433020.
    10.1042/bcj20160407
  35. Baiceanu E; Nguyen KA; Gonzalez-Lobato L; Nasr R; Baubichon-Cortay H; Loghin F; Le Borgne M; et al. "2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.". European journal of medicinal chemistry (2016): http://europepmc.org/abstract/med/27393949.
    10.1016/j.ejmech.2016.06.039
  36. Chaptal V; Kilburg A; Flot D; Wiseman B; Aghajari N; Jault JM; Falson P. "Diffraction anisotropy falloff in the direction of the detergent belt for two centered monoclinic crystals of OmpF.". Data in brief (2016): http://europepmc.org/abstract/med/27054185.
    10.1016/j.dib.2016.03.031
  37. Gonzalez-Lobato L; Chaptal V; Molle J; Falson P. "Leishmania tarentolae as a Promising Tool for Expressing Polytopic and Multi-Transmembrane Spans Eukaryotic Membrane Proteins: The Case of the ABC Pump ABCG6.". Methods in molecular biology (Clifton, N.J.) (2016): http://europepmc.org/abstract/med/27485333.
    10.1007/978-1-4939-3637-3_8
  38. Redhu, A.K.; Khandelwal, N.K.; Banerjee, A.; Moreno, A.; Falson, P.; Prasad, R.. "PHluorin enables insights into the transport mechanism of antiporter Mdr1: R215 is critical for drug/H+ antiport". Biochemical Journal 473 19 (2016): 3127-3145. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009964871&partnerID=MN8TOARS.
    10.1042/BCJ20160407
  39. Chaptal V; Kilburg A; Flot D; Wiseman B; Aghajari N; Jault JM; Falson P. "Two different centered monoclinic crystals of the E. coli outer-membrane protein OmpF originate from the same building block.". Biochimica et biophysica acta (2015): http://europepmc.org/abstract/med/26620074.
    10.1016/j.bbamem.2015.11.021
  40. Baiceanu E; Crisan G; Loghin F; Falson P. "Modulators of the human ABCC2: hope from natural sources?". Future medicinal chemistry (2015): http://europepmc.org/abstract/med/26496229.
    10.4155/fmc.15.131
  41. Falson P; Bartosch B; Alsaleh K; Tews BA; Loquet A; Ciczora Y; Riva L; et al. "Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion.". Journal of virology (2015): http://europepmc.org/abstract/med/26246575.
    10.1128/JVI.00991-15
  42. Kinclova-Zimmermannova O; Falson P; Cmunt D; Sychrova H. "A hydrophobic filter confers the cation selectivity of Zygosaccharomyces rouxii plasma-membrane Na+/H+ antiporter.". Journal of molecular biology (2015): http://europepmc.org/abstract/med/25701798.
    10.1016/j.jmb.2015.02.012
  43. Wiseman B; Kilburg A; Chaptal V; Reyes-Mejia GC; Sarwan J; Falson P; Jault JM. "Stubborn contaminants: influence of detergents on the purity of the multidrug ABC transporter BmrA.". PloS one (2014): http://europepmc.org/abstract/med/25517996.
    10.1371/journal.pone.0114864
  44. Kunert B; Gardiennet C; Lacabanne D; Calles-Garcia D; Falson P; Jault JM; Meier BH; Penin F; Böckmann A. "Efficient and stable reconstitution of the ABC transporter BmrA for solid-state NMR studies.". Frontiers in molecular biosciences (2014): http://europepmc.org/abstract/med/25988146.
    10.3389/fmolb.2014.00005
  45. Martinez L; Arnaud O; Henin E; Tao H; Chaptal V; Doshi R; Andrieu T; et al. "Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein.". The FEBS journal (2014): http://europepmc.org/abstract/med/24219411.
    10.1111/febs.12613
  46. Ward AB; Szewczyk P; Grimard V; Lee CW; Martinez L; Doshi R; Caya A; et al. "Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.". Proceedings of the National Academy of Sciences of the United States of America (2013): http://europepmc.org/abstract/med/23901103.
    10.1073/pnas.1309275110
  47. Gros G; Martinez L; Gimenez AS; Adler P; Maurin P; Wolkowicz R; Falson P; Hasserodt J. "Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease.". Bioorganic & medicinal chemistry (2013): http://europepmc.org/abstract/med/23911197.
    10.1016/j.bmc.2013.06.018
  48. Honorat M; Terreux R; Falson P; Di Pietro A; Dumontet C; Payen L. "Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico models.". BMC structural biology (2013): http://europepmc.org/abstract/med/23641929.
    10.1186/1472-6807-13-7
  49. Sostelly A; Payen L; Guitton J; Di Pietro A; Falson P; Honorat M; Boumendjel A; et al. "Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model.". Fundamental & clinical pharmacology (2013): http://europepmc.org/abstract/med/23384250.
    10.1111/fcp.12005
  50. Sostelly A; Payen L; Guitton J; Di Pietro A; Falson P; Honorat M; Valdameri G; et al. "A template model for studying anticancer drug efflux transporter inhibitors in vitro.". Fundamental & clinical pharmacology (2012): http://europepmc.org/abstract/med/22882086.
    10.1111/j.1472-8206.2012.01054.x
  51. Ferrandez Y; Monlezun L; Phan G; Benabdelhak H; Benas P; Ulryck N; Falson P; et al. "Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis.". Electrophoresis (2012): http://europepmc.org/abstract/med/22589107.
    10.1002/elps.201100541
  52. Valdameri G; Pereira Rangel L; Spatafora C; Guitton J; Gauthier C; Arnaud O; Ferreira-Pereira A; et al. "Methoxy stilbenes as potent, specific, untransported, and noncytotoxic inhibitors of breast cancer resistance protein.". ACS chemical biology (2011): http://europepmc.org/abstract/med/22039929.
    10.1021/cb200435y
  53. Honorat M; Falson P; Terreux R; Di Pietro A; Dumontet C; Payen L. "Multidrug resistance ABC transporter structure predictions by homology modeling approaches.". Current drug metabolism (2011): http://europepmc.org/abstract/med/21470105.
    10.2174/138920011795101804
  54. Matar-Merheb R; Rhimi M; Leydier A; Huché F; Galián C; Desuzinges-Mandon E; Ficheux D; et al. "Structuring detergents for extracting and stabilizing functional membrane proteins.". PloS one (2011): http://europepmc.org/abstract/med/21483854.
    10.1371/journal.pone.0018036
  55. Boumendjel A; Macalou S; Valdameri G; Pozza A; Gauthier C; Arnaud O; Nicolle E; et al. "Targeting the multidrug ABCG2 transporter with flavonoidic inhibitors: in vitro optimization and in vivo validation.". Current medicinal chemistry (2011): http://europepmc.org/abstract/med/21728961.
    10.2174/092986711796504736
  56. Arnaud O; Boumendjel A; Gèze A; Honorat M; Matera EL; Guitton J; Stein WD; et al. "The acridone derivative MBLI-87 sensitizes breast cancer resistance protein-expressing xenografts to irinotecan.". European journal of cancer (Oxford, England : 1990) (2011): http://europepmc.org/abstract/med/21216589.
    10.1016/j.ejca.2010.11.019
  57. Arnaud O; Koubeissi A; Ettouati L; Terreux R; Alamé G; Grenot C; Dumontet C; et al. "Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.". Journal of medicinal chemistry (2010): http://europepmc.org/abstract/med/20731360.
    10.1021/jm100839w
  58. Dezi M; Fribourg PF; Di Cicco A; Arnaud O; Marco S; Falson P; Di Pietro A; Lévy D. "The multidrug resistance half-transporter ABCG2 is purified as a tetramer upon selective extraction from membranes.". Biochimica et biophysica acta (2010): http://europepmc.org/abstract/med/20691149.
    10.1016/j.bbamem.2010.07.034
  59. Desuzinges-Mandon E; Arnaud O; Martinez L; Huché F; Di Pietro A; Falson P. "ABCG2 transports and transfers heme to albumin through its large extracellular loop.". The Journal of biological chemistry (2010): http://europepmc.org/abstract/med/20705604.
    10.1074/jbc.M110.139170
  60. Trometer C; Falson P. "Mammalian membrane protein expression in baculovirus-infected insect cells.". Methods in molecular biology (Clifton, N.J.) (2010): http://europepmc.org/abstract/med/20099142.
    10.1007/978-1-60761-344-2_7
  61. Suwinska, K.; Shkurenko, O.; Mbemba, C.; Leydier, A.; Jebors, S.; Coleman, A.W.; Matar, R.; Falson, P.. "Trianionic calix[4]arene monoalkoxy derivatives: Synthesis, solid-state structures and self-assembly properties". New Journal of Chemistry 32 11 (2008): 1988-1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-55349137371&partnerID=MN8TOARS.
    10.1039/b806342g
  62. Nagy Z; Montigny C; Leverrier P; Yeh S; Goffeau A; Garrigos M; Falson P. "Role of the yeast ABC transporter Yor1p in cadmium detoxification.". Biochimie (2006): http://europepmc.org/abstract/med/16814918.
    10.1016/j.biochi.2006.05.014
  63. Lenoir G; Jaxel C; Picard M; le Maire M; Champeil P; Falson P. "Conformational changes in sarcoplasmic reticulum Ca(2+)-ATPase mutants: effect of mutations either at Ca(2+)-binding site II or at tryptophan 552 in the cytosolic domain.". Biochemistry (2006): http://europepmc.org/abstract/med/16618114.
    10.1021/bi0522091
  64. Corvest V; Sigalat C; Venard R; Falson P; Mueller DM; Haraux F. "The binding mechanism of the yeast F1-ATPase inhibitory peptide: role of catalytic intermediates and enzyme turnover.". The Journal of biological chemistry (2005): http://europepmc.org/abstract/med/15640141.
    10.1074/jbc.m414098200
  65. Corvest, V.; Sigalat, C.; Venard, R.; Falson, P.; Mueller, D.M.; Haraux, F.. "The binding mechanism of the yeast F1-ATPase inhibitory peptide: Role of catalytic intermediates and enzyme turnover". Journal of Biological Chemistry 280 11 (2005): 9927-9936. http://www.scopus.com/inward/record.url?eid=2-s2.0-15444378739&partnerID=MN8TOARS.
    10.1074/jbc.M414098200
  66. Girard P; Pécréaux J; Lenoir G; Falson P; Rigaud JL; Bassereau P. "A new method for the reconstitution of membrane proteins into giant unilamellar vesicles.". Biophysical journal (2004): http://europepmc.org/abstract/med/15240476.
    10.1529/biophysj.104.040360
  67. Falson P; Goffeau A; Boutry M; Jault JM. "Structural insight into the cooperativity between catalytic and noncatalytic sites of F1-ATPase.". Biochimica et biophysica acta (2004): http://europepmc.org/abstract/med/15282184.
    10.1016/j.bbabio.2004.05.008
  68. Lenoir G; Picard M; Møller JV; le Maire M; Champeil P; Falson P. "Involvement of the L6-7 loop in SERCA1a Ca2+-ATPase activation by Ca2+ (or Sr2+) and ATP.". The Journal of biological chemistry (2004): http://europepmc.org/abstract/med/15155750.
    10.1074/jbc.m402934200
  69. Montigny C; Penin F; Lethias C; Falson P. "Overcoming the toxicity of membrane peptide expression in bacteria by upstream insertion of Asp-Pro sequence.". Biochimica et biophysica acta (2004): http://europepmc.org/abstract/med/14757220.
  70. Lenoir, G.; Picard, M.; Gauron, C.; Montigny, C.; Le Maréchal, P.; Falson, P.; Le Maire, M.; Møller, J.V.; Champeil, P.. "Functional Properties of Sarcoplasmic Reticulum Ca2+-ATPase after Proteolytic Cleavage at Leu119-LYS120, Close to the A-domain". Journal of Biological Chemistry 279 10 (2004): 9156-9166. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542335434&partnerID=MN8TOARS.
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  71. Lenoir, G.; Picard, M.; Møller, J.V.; Le Maire, M.; Champeil, P.; Falson, P.. "Involvement of the L6-7 loop in SERCA1a Ca2+-ATPase activation by Ca2+ (or Sr2+) and ATP". Journal of Biological Chemistry 279 31 (2004): 32125-32133. http://www.scopus.com/inward/record.url?eid=2-s2.0-3542992047&partnerID=MN8TOARS.
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  72. Montigny, C.; Penin, F.; Lethias, C.; Falson, P.. "Overcoming the toxicity of membrane peptide expression in bacteria by upstream insertion of Asp-Pro sequence". Biochimica et Biophysica Acta - Biomembranes 1660 1-2 (2004): 53-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642575121&partnerID=MN8TOARS.
    10.1016/j.bbamem.2003.10.013
  73. Girard, P.; Pécréaux, J.; Lenoir, G.; Falson, P.; Rigaud, J.-L.; Bassereau, P.. "Erratum: A new method for the reconstitution of membrane proteins into giant unilamellar vesicles (Biophysical Journal 87 (419-429))". Biophysical Journal 87 3 (2004): 2098-2098. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444270809&partnerID=MN8TOARS.
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  74. Lenoir G; Picard M; Gauron C; Montigny C; Le Maréchal P; Falson P; Le Maire M; Møller JV; Champeil P. "Functional properties of sarcoplasmic reticulum Ca(2+)-ATPase after proteolytic cleavage at Leu119-Lys120, close to the A-domain.". The Journal of biological chemistry (2003): http://europepmc.org/abstract/med/14672956.
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  75. Corre F; Jaxel C; Fuentes J; Menguy T; Falson P; Levine BA; Møller JV; le Maire M. "Involvement of the cytoplasmic loop L6-7 in the entry mechanism for transport of Ca2+ through the sarcoplasmic reticulum Ca2+-ATPase.". Annals of the New York Academy of Sciences (2003): http://europepmc.org/abstract/med/12763779.
    10.1111/j.1749-6632.2003.tb07143.x
  76. Falson P; Lenoir G; Menguy T; Corre F; Montigny C; Pedersen PA; Thinès D; Le Maire M. "Overexpression of SERCA1a Ca2+-ATPase in yeast.". Annals of the New York Academy of Sciences (2003): http://europepmc.org/abstract/med/12763834.
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  77. Lenoir G; Montigny C; Le Maire M; Falson P. "Purification of SERCA1a Ca2+-ATPase mutants expressed in yeast.". Annals of the New York Academy of Sciences (2003): http://europepmc.org/abstract/med/12763842.
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  78. Lenoir G; Menguy T; Corre F; Montigny C; Pedersen PA; Thinès D; le Maire M; Falson P. "Overproduction in yeast and rapid and efficient purification of the rabbit SERCA1a Ca(2+)-ATPase.". Biochimica et biophysica acta (2002): http://europepmc.org/abstract/med/11958776.
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  82. Chami M; Gozuacik D; Lagorce D; Brini M; Falson P; Peaucellier G; Pinton P; et al. "SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis.". The Journal of cell biology (2001): http://europepmc.org/abstract/med/11402072.
    10.1083/jcb.153.6.1301
  83. Fuentes JM; Lompré AM; Møller JV; Falson P; le Maire M. "Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al.". Analytical biochemistry (2000): http://europepmc.org/abstract/med/11017716.
    10.1006/abio.2000.4784
  84. Chami M; Gozuacik D; Saigo K; Capiod T; Falson P; Lecoeur H; Urashima T; et al. "Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis.". Oncogene (2000): http://europepmc.org/abstract/med/10871838.
    10.1038/sj.onc.1203605
  85. Groves JD; Parker MD; Askin D; Falson P; le Maire M; Tanner MJ. "Heterologous expression of the red-cell anion exchanger (band 3; AE1).". Biochemical Society transactions (1999): http://europepmc.org/abstract/med/10830128.
    10.1042/bst0270917
  86. Menguy T; Chenevois S; Guillain F; le Maire M; Falson P; Champeil P. "Ligand binding to macromolecules or micelles: use of centrifugal ultrafiltration to measure low-affinity binding.". Analytical biochemistry (1998): http://europepmc.org/abstract/med/9866675.
    10.1006/abio.1998.2854
  87. Menguy T; Corre F; Bouneau L; Deschamps S; Møller JV; Champeil P; le Maire M; Falson P. "The cytoplasmic loop located between transmembrane segments 6 and 7 controls activation by Ca2+ of sarcoplasmic reticulum Ca2+-ATPase.". The Journal of biological chemistry (1998): http://europepmc.org/abstract/med/9685357.
    10.1074/jbc.273.32.20134
  88. Champeil P; Menguy T; Soulié S; Juul B; de Gracia AG; Rusconi F; Falson P; et al. "Characterization of a protease-resistant domain of the cytosolic portion of sarcoplasmic reticulum Ca2+-ATPase. Nucleotide- and metal-binding sites.". The Journal of biological chemistry (1998): http://europepmc.org/abstract/med/9506958.
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  89. Moller JV; Ning G; Maunsbach AB; Fujimoto K; Asai K; Juul B; Lee YJ; et al. "Probing of the membrane topology of sarcoplasmic reticulum Ca2+-ATPase with sequence-specific antibodies. Evidence for plasticity of the c-terminal domain.". The Journal of biological chemistry (1997): http://europepmc.org/abstract/med/9360975.
    10.1074/jbc.272.46.29015
  90. Møller JV; Juul B; Falson P; Le Maire M. "Probing of membrane topology and stability of sarcoplasmic reticulum Ca(2+)-ATPase and Na+,K+ -ATPase with sequence-specific antibodies.". Annals of the New York Academy of Sciences (1997): http://europepmc.org/abstract/med/9432907.
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  91. Falson P; Menguy T; Corre F; Bouneau L; de Gracia AG; Soulié S; Centeno F; et al. "The cytoplasmic loop between putative transmembrane segments 6 and 7 in sarcoplasmic reticulum Ca2+-ATPase binds Ca2+ and is functionally important.". The Journal of biological chemistry (1997): http://europepmc.org/abstract/med/9211861.
    10.1074/jbc.272.28.17258
  92. Dong M; Baggetto LG; Falson P; Le Maire M; Penin F. "Complete removal and exchange of sodium dodecyl sulfate bound to soluble and membrane proteins and restoration of their activities, using ceramic hydroxyapatite chromatography.". Analytical biochemistry (1997): http://europepmc.org/abstract/med/9177696.
    10.1006/abio.1997.2103
  93. Corre, F.; Bouneau, L.; Le Maire, M.; Falson, P.. "Improvement of the spun column procedure to purify plasmid DNA". International Journal of Bio-Chromatography 3 2 (1997): 137-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030758789&partnerID=MN8TOARS.
  94. Groves JD; Falson P; le Maire M; Tanner MJ. "Functional cell surface expression of the anion transport domain of human red cell band 3 (AE1) in the yeast Saccharomyces cerevisiae.". Proceedings of the National Academy of Sciences of the United States of America (1996): http://europepmc.org/abstract/med/8901565.
    10.1073/pnas.93.22.12245
  95. Soulié S; Møller JV; Falson P; le Maire M. "Urea reduces the aggregation of membrane proteins on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.". Analytical biochemistry (1996): http://europepmc.org/abstract/med/8660521.
    10.1006/abio.1996.0183
  96. Centeno, F.; Deschamps, S.; Lompré, A.-M.; Anger, M.; Moutin, M.-J.; Dupont, Y.; Gjedde Palmgren, M.; et al. "Expression of sarcoplasmic reticulum CA2+-ATPase in yeast (PII:0014-5793(94)01104-4)". FEBS Letters 358 1 (1995): 104-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028908949&partnerID=MN8TOARS.
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  98. Falson P; Penin F; Divita G; Lavergne JP; Di Pietro A; Goody RS; Gautheron DC. "Functional nucleotide-binding domain in the F0F1-ATPsynthase alpha subunit from the yeast Schizosaccharomyces pombe.". Biochemistry (1993): http://europepmc.org/abstract/med/8399182.
    10.1021/bi00090a014
  99. Falson P. "An efficient procedure to dialyze volumes in the range of 10-200 microliters.". BioTechniques (1992): http://europepmc.org/abstract/med/1503766.
  100. Falson, P.. "An efficient procedure to dialyze volumes in the range of 10-200 µl". BioTechniques 13 1 (1992): 20-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026717971&partnerID=MN8TOARS.
  101. Falson P; Leterme S; Capiau C; Boutry M. "Beta subunit of mitochondrial F1-ATPase from the fission yeast. Deduced sequence of the wild type protein and identification of a mutation that increases nucleotide binding.". European journal of biochemistry (1991): http://europepmc.org/abstract/med/1831760.
    10.1111/j.1432-1033.1991.tb21048.x
  102. Jault JM; Di Pietro A; Falson P; Gautheron DC. "Alteration of apparent negative cooperativity of ATPase activity by alpha-subunit glutamine 173 mutation in yeast mitochondrial F1. Correlation with impaired nucleotide interaction at a regulatory site.". The Journal of biological chemistry (1991): http://europepmc.org/abstract/med/1827117.
  103. Falson P; Maffey L; Conrath K; Boutry M. "Alpha subunit of mitochondrial F1-ATPase from the fission yeast. Deduced sequence of the wild type and identification of a mutation that alters apparent negative cooperativity.". The Journal of biological chemistry (1991): http://europepmc.org/abstract/med/1824697.
  104. Jault, J.-M.; Di Pietro, A.; Falson, P.; Gautheron, D.C.. "Alteration of apparent negative cooperativity of ATPase activity by a-subunit glutamine 173 mutation in yeast mitochondrial F1: Correlation with impaired nucleotide interaction at a regulatory site". Journal of Biological Chemistry 266 13 (1991): 8073-8078. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025775976&partnerID=MN8TOARS.
  105. Falson, P.; Maffey, L.; Conrath, K.; Boutry, M.. "a Subunit of mitochondrial F1-ATPase from the fission yeast. Deduced sequence of the wild type and identification of a mutation that alters apparent negative cooperativity". Journal of Biological Chemistry 266 1 (1991): 287-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026074361&partnerID=MN8TOARS.
  106. Di Pietro A; Jault JM; Falson P; Divita G; Gautheron DC. "Structure-function relationships of mitochondrial ATPase-ATPsynthase using Schizosaccharomyces pombe yeast mutants with altered F1 subunits.". Biochimie (1989): http://europepmc.org/abstract/med/2529909.
    10.1016/0300-9084(89)90075-8
  107. Falson P; Di Pietro A; Jault JM; Gautheron DC; Boutry M. "Purification from a yeast mutant of mitochondrial F1 with modified beta-subunit. High affinity for nucleotides and high negative cooperativity of ATPase activity.". Biochimica et biophysica acta (1989): http://europepmc.org/abstract/med/2525405.
  108. Jault JM; Di Pietro A; Falson P; Gautheron DC; Boutry M; Goffeau A. "A yeast strain with mutated beta-subunits of mitochondrial ATPase-ATPsynthase: high azide and bicarbonate sensitivity of the ATPase activity.". Biochemical and biophysical research communications (1989): http://europepmc.org/abstract/med/2521789.
    10.1016/s0006-291x(89)80060-9
  109. Falson, P.; Di Pietro, A.; Jault, J.-M.; Gautheron, D.C.; Boutry, M.. "Purification from a yeast mutant of mitochondrial F1 with modified ß-subunit. High affinity for nucleotides and high negative cooperativity of ATPase activity". BBA - Bioenergetics 975 1 (1989): 119-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024976967&partnerID=MN8TOARS.
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  110. Jault, J.M.; Di Pietro, A.; Falson, P.; Gautheron, D.C.; Boutry, M.; Goffeau, A.. "A yeast strain with mutated ß-subunits of mitochondrial ATPase-ATPsynthase: High azide and bicarbonate sensitivity of the ATPase activity". Biochemical and Biophysical Research Communications 158 2 (1989): 392-399. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024538292&partnerID=MN8TOARS.
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  111. Falson P; Di Pietro A; Darbouret D; Jault JM; Gautheron DC; Boutry M; Goffeau A. "Revertant of the yeast Schizosaccharomyces pombe with modified alpha subunits of mitochondrial ATPase-ATPsynthase: impaired nucleotide interactions with soluble and membrane-bound enzyme.". Biochemical and biophysical research communications (1987): http://europepmc.org/abstract/med/2891355.
    10.1016/s0006-291x(87)80257-7
  112. Falson, P.; Di Pietro, A.; Darbouret, D.; Jault, J.M.; Gautheron, D.C.; Boutry, M.; Goffeau, A.. "Revertant of the yeast Schizosaccharomyces pombe with modified a subunits of mitochondrial ATPase-ATPsynthase: Impaired nucleotide interactions with soluble and membrane-bound enzyme". Biochemical and Biophysical Research Communications 148 3 (1987): 1182-1188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023652827&partnerID=MN8TOARS.
    10.1016/S0006-291X(87)80257-7
  113. Falson P; Di Pietro A; Gautheron DC. "Chemical modification of thiol groups of mitochondrial F1-ATPase from the yeast Schizosaccharomyces pombe. Involvement of alpha- and gamma-subunits in the enzyme activity.". The Journal of biological chemistry (1986): http://europepmc.org/abstract/med/2872213.
  114. Falson, P.; Di Pietro, A.; Gautheron, D.C.. "Chemical modification of thiol groups of mitochondrial F1-ATPase from the yeast Schizosaccharomyces pombe. Involvement of a- and ¿-subunits in the enzyme activity". Journal of Biological Chemistry 261 16 (1986): 7151-7159. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022899463&partnerID=MN8TOARS.