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Francisca Sarreira Simões Horta Monteiro Short CV Overview: My research is focused on bacterial persistence - I combine experimental analyses with mathematical modelling to study how persister cells shape evolution of antibiotic resistance. My aim is to identify targets for the development of new antimicrobial therapies, aiding in the fight against recurrent and resistant bacterial infections. I have 13 years of experience in metabolic research and consolidated know-how in molecular, synthetic, and systems biology. To complement my experimental skills, I have been using mathematical models to understand and optimize biological processes. Recently, I acquired practical knowledge in single cell analysis and respective enabling technologies (microfluidics and time-lapse microscopy). Current position: Postdoc fellow at cE3c (University of Lisbon). Education: 2019/09/1 - present - MSc in Medicine (NOVA University of Lisbon); 2015/09/14 - PhD in Biotechnology (NOVA University of Lisbon); 2009/12/11 - MSc in Applied Microbiology (University of Lisbon); 2008/07/18 - BSc in Microbiology (University of Lisbon). Research Outputs: Publications - 11 peer-reviewed papers, 4 as main author, 1 invited review paper as first-author, 5 conference proceedings; Participation in Conferences - 13 oral communications in international and national scientific meetings ,7 as main author and 3 invited, and 16 posters as main author. Teaching activities: Virology course (theoretical and practical lessons) for the Masters in Molecular Biology and Genetics (Faculty of Sciences, University of Lisbon); Persistence seminars for the Advanced Topics in Microbiology course of the Master in Applied Microbiology (Faculty of sciences, University of Lisbon). Jury of academic degree: Main opponent in the Master Thesis defense of Rodrigo Nogueira, entitled Pseudotyped lentiviral vectors for gene therapy: impact of envelope glycoproteins (2019), developed in the scope of the Masters in Medical Microbiology, (NOVA Medical School, Portugal). Supervision: 1 PhD student as co-supervisor (on-going); 3 Master and 1 Bachelor Students; 10 research trainees in lab rotations (BSc and MSc level). Distinctions, fellowships and awards: European Commission Seal of Excellence Marie Sklodowska-Curie Actions; Spotlight research paper, selected by Biotechnology and Bioengineering journal editor; Best poster prize at Vaccine Technology V Conference; FCT - Postdoc and PhD fellowships; FCT - Travel and accommodation grants; ESACT - 3 travel and 2 conference grants. Participation in international projects: Team member and consultant in 3 European and 7 FCT projects. Commissions of trust: Reviewer in international Q1 peer-reviewed journals (Journal of Biotechnology, Applied Microbiology and Biotechnology). Organisation of scientific meetings: Member of the organising committees of the 3rd Joint Post-doc Retreat (2015) and the 4th ITQB PhD Students Meeting (2013). Public Outreach: Science communication actions to general public at European Researchers Night, ITQB-NOVA and Faculty of Sciences Open Day.
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Identification

Personal identification

Full name
Francisca Sarreira Simões Horta Monteiro

Citation names

  • Monteiro, Francisca

Author identifiers

Ciência ID
A815-CE3A-53C9
ORCID iD
0000-0002-5275-714X

Email addresses

  • fsmonteiro@fc.ul.pt (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Engineering and Technology - Industrial Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2019/09/01 - 2025/08/01
Ongoing
 Medicina (Mestrado integrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011/01/01 - 2015/09/14
Concluded
 Doutoramento em Ciências da Engenharia e Tecnologia (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Rational design of insect cell-based vaccine production: Bridging metabolomics with mathematical tools to study virus-host interactions" (THESIS/DISSERTATION)
 Aprovada por unanimidade
2008/09/01 - 2009/12/11
Concluded
 Mestrado em Microbiologia Aplicada (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"The cell density effect on the baculovirus-insect cell interaction: A metabolic perspective" (THESIS/DISSERTATION)
 18
2004/09/12 - 2008/07/18
Concluded
 Licenciatura em Microbiologia (Licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
"Mutagenesis by allelic exchange in Mycobacterium sp." (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2018/11/01 - Current Postdoc (Research) Centro de Ecologia Evolução e Alterações Ambientais, Portugal
Centro de Ecologia Evolução e Alterações Ambientais, Portugal
2017/09/01 - 2018/02/28 Postdoc (Research) Rijksuniversiteit Groningen Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands
2016/11/15 - 2017/08/31 Contracted Researcher (Research) Rijksuniversiteit Groningen Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands
2015/10/01 - 2016/10/31 Postdoc (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
2009/12/13 - 2010/12/31 Research Trainee (Research) Instituto de Biologia Experimental e Tecnológica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/09 - 2023/02 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09 - 2022/02 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/16 - 2020/02 Lecturer (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2020/06/01 - 2021/04/30 Sick and maternity leave Centro de Ecologia Evolução e Alterações Ambientais, Portugal
2018/03/01 - 2018/10/31 Sick and maternity leave Centro de Ecologia Evolução e Alterações Ambientais, Portugal
2011/01/01 - 2015/09/30 PhD Student Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/03/01 - 2014/04/01 Visiting PhD Student European Molecular Biology Laboratory, France
2012/02/01 - 2012/05/01 Visiting PhD Student Universidad de Murcia Facultad de Química, Spain
2008/09/01 - 2009/12/11 Master Student Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2007/09/01 - 2008/07/01 Bachelor Student Trainee Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2017/09/01 - Current Evolutionary Systems Biology: Mining persistence formation and the road to drug resistance
SFRH/BPD/123504/2016
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2010/01/01 - 2014/12/31 Rational design of insect cell-based vaccine production: Bridging metabolomics with mathematical tools to study virus-host interactions
SFRH / BD / 70139 / 2010
PhD Student Fellow
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2021 - 2025 CHANGE - Instituto para as Alterações Globais e Sustentabilidade
LA/P/0121/2020
10.54499/LA/P/0121/2020
Universidade de Évora, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Centro de Ecologia, Evolução e Alterações Ambientais
UID/BIA/00329/2019
UIDB/00329/2020
10.54499/UIDB/00329/2020
UIDP/00329/2020
10.54499/UIDP/00329/2020
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Fundação Gaspar Frutuoso, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Centro de Ecologia Evolução e Alterações Ambientais, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Coimbra Faculdade de Psicologia e de Ciências da Educação, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2017 Programming synthetic networks for bio-based production of value chemicals
info:eu-repo/grantAgreement/EC/FP7/613745/EU
Post-doc
European Commission
Concluded
2016 - 2016 Investigating Novel Valuable bio-Therapeutics and Expression systems
info:eu-repo/grantAgreement/FCT/3599-PPCDT/137215/PT
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2016 The architecture of life: Probing the quaternary structure of virus capsids by native mass spectrometry
info:eu-repo/grantAgreement/FCT/3599-PPCDT/125109/PT
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2016 Combinatorial immunization strategy to educate the immune system towards cross recognition and coverage against antigenic drift in seasonal influenza virus exposure
info:eu-repo/grantAgreement/EC/FP7/602640/EU
Technical development
European Commission
Concluded
2014 - 2015 Establishment of a flexible insect cell platform for fast production of pseudo-typed VLPs for drug and vaccine development
info:eu-repo/grantAgreement/FCT/3599-PPCDT/134566/PT
Technical development
European Commission
Concluded
2011 - 2015 New Technologies and Production Tools for Complex Protein Biologics
info:eu-repo/grantAgreement/EC/FP7/279039/EU
Technical development
European Commission
Concluded
2011 - 2012 BACULOME-Engineering cellular energetics for improvement of bioprocesses: metabolic modeling for enhanced vaccines production.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/103359/PT
Technical development
European Commission
Concluded
2009 - 2010 BACULOGENES - Baculovirus vectors for gene therapy
FP6 LHSB-CT-2006-037541
Scientific Initiation Fellow
European Commission
Concluded
Outputs

Publications

Conference paper
  1. Monteiro, Francisca; Bernal, Vicente; Alves, Paula M.. "Metabolic analysis and modeling approaches to drive enveloped viral particles production in the Insect Cell-BaculoVirus Expression System". Paper presented in 17th European Congress on Biotechnology, Krakow, 2016.
    Published • 10.1016/j.nbt.2016.06.848
  2. Carvalho, Sofia; Freire, João; Moleirinho, Mafalda; Monteiro, Francisca; Gaspar, Diana; Castanho, Miguel; Alves, Paula M; et al. "A click chemistry strategy to specifically monitor and improve purification of Influenza virus-like particles". Paper presented in Vaccine Technology VI, Albufeira, 2016.
    Published
  3. Monteiro, Francisca; Bernal, Vicente; Alves, Paula M.. "Metabolic drivers of IC-BEVS productivity: Tackling the production of enveloped viral particles". Paper presented in Vaccine Technology VI, Albufeira, 2016.
    Published
  4. Monteiro, Francisca; Bernal, Vicente; Chaillet, Maxime; Berger, Imre; Alves, Paula Marques. "Enhancing enveloped viral particles production by targeted supplementation design: Releasing bottlenecks in IC-BEVS". Paper presented in Cell Culture Engineering XV, 2016.
    Published
  5. Bernal, Vicente; Carinhas, Nuno; Monteiro, Francisca; Ambrósio, Raquel; Carrondo, Manuel J.T.; Alves, Paula M. "An Insight into the Physiology of Insect Cells: The Role of Energetic Metabolism on the Cell Density Effect". Paper presented in 21st Meeting of the European Society for Animal Cell Technology, Dublin, 2009.
    Published
Conference poster
  1. Joao S. Rebelo; Celia P. F. Domingues; Monteiro, Francisca; Nogueira, Teresa; Dionisio, Francisco. "Human social interactions shape the distribution of pathogenicity and antibiotic- resistance genes". Paper presented in XVIII ENBE Annual Meeting of the Portuguese Association for Evolutionary Biology, 2022.
  2. Rebelo, J. S.; Célia P. F. Domingues; Monteiro, Francisca; Nogueira, Teresa; Dionisio, Francisco. "Plasmid transfer as a weapon against plasmid-free cells - a strategy that leads to plasmid maintenance". Paper presented in RECOMB 2021 - 25th International Conference on Research in Computational Molecular Biology, 2021.
  3. Domingues, C. P. F.; Rebelo, J. S.; Monteiro, Francisca; Nogueira, Teresa; Dionisio, Francisco. "Why is there a positive correlation between the diversity of virulence and antibiotic-resistance genes?". Paper presented in RECOMB 2021 - 25th International Conference on Research in Computational Molecular Biology, 2021.
  4. Domingues, Célia; Rebelo, João; Nogueira, Teresa; Pothier, Joel; Monteiro, Francisca; Dionisio, Francisco. "Ratio between contagion probability and resistance gene loss rate is key for the emergence of positive correlation between antibiotic resistance gene diversity and virulence gene diversity in human metagenomes". Paper presented in Ciências Research Day, 2020.
  5. Rebelo, João; Domingues, Célia; Monteiro, Francisca; Nogueira, Teresa; Dionisio, Francisco. "Long life of persister cells - faults and errors resulting in a power-law decay". Paper presented in Ciências Research Day, 2020.
  6. Monteiro, Francisca; Hubmann, Georg; Norder, Justin; Saldida, Joana; Litsios, Athanasis; Wijma, Hein; Schmidt, Alexander; Heinemann, Matthias. "Measuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor". Paper presented in Emerging Applications of Microbes, 2019.
  7. Monteiro, Francisca; Hubmann, Georg; Norder, Justin; Saldida, Joana; Litsios, Athanasios; Wijma, Hein; Schmidt, Alexander. "Measuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor". Paper presented in Yeasterday, 2019.
  8. Monteiro, Francisca; Hubmann, Georg; Norder, Justin; Wijma, Hein; Schmidt, Alexander; Heinemann, Matthias. "An orthogonal flux-sensing system for quantification of metabolic flux in Saccharomyces cerevisiae". Paper presented in GBB Symposium, 2017.
  9. Monteiro, Francisca; Bernal, Vicente; Marques, Paula M.. "Metabolic drivers of IC-BEVS productivity: tackling the production of enveloped viral particles". Paper presented in Vaccine Technology VI, 2016.
  10. Monteiro, Francisca; Bernal, Vicente; Chaillet, Maxime; Berger, Imre; Alves, Paula M.. "Enhancing enveloped viral particles production by targeted supplementation design: Releasing bottlenecks in IC-BEVS". Paper presented in Cell Culture Engineering XV, 2016.
  11. Monteiro, Francisca; Bernal, Vicente; Alves, Paula Marques. "Comparative fluxome analysis of the IC-BEVS: the role of host cell line physiology in systems productivity". Paper presented in Cell Culture Engineering XV, 2016.
  12. Monteiro, Francisca; Bernal, Vicente; Chaillet, Maxime; Berger, Imre; Alves, Paula Marques. "Tackling bottlenecks in IC-BEVS: Enhancing enveloped viral particles production by targeted supplementation design". Paper presented in Influenza Vaccines for the World, 2015.
  13. Monteiro, Francisca; Bernal, Vicente; Chaillet, Maxime; Berger, Imre; Alves, Paula Marques. "Boosting production and quality of enveloped viral particles in bevs: host cell-driven and target-oriented approaches". Paper presented in 8th Recombinant Protein Production Conference, 2015.
  14. Monteiro, Francisca; Bernal, Vicente; Hamdi, Anis; Chaillet, Maxime; Drnkova, Petra; Berger, Imre; Alves, Paula M.. "Tweaking insect cell platforms for the production of multivalent VLPs: Metabolic profiling, pathway analysis and bioprocess optimization". Paper presented in Vaccine Technology V, 2014.
  15. Monteiro, Francisca; Dias, Mafalda; Vidigal, João; Fernandes, Fabiana; Castro, Rute; Patrone, Marco; Carrondo, Manuel J T; et al. "Tuning insect cell platforms for the production of complex biopharmaceuticals". Paper presented in Cell Culture Engineering XIV, 2014.
  16. Monteiro, Francisca; Bernal, Vicente; Sevilla, Angel; Bernal, Cristina; Lozano, Ana B.; Carrondo, Manuel J.T.; Alves, Paula M.. "Metabolic fingerprinting of insect cell lines: Disclosing cell line determinants behind system’s productivity". Paper presented in 23rd ESACT Meeting, 2013.
  17. Monteiro, Francisca; Bernal, Vicente; Alves, Paula Marques. "In-depth metabolic analysis of baculovirus-host interactions". Paper presented in 7th Conference on Recombinant Protein Production, 2013.
  18. Monteiro, Francisca; Bernal, Vicente; Alves, Paula Marques. "Systems-level analysis of baculovirus-host interactions: From genomic to metabolomic decomposition". Paper presented in 3rd ITQB PhD Students' Meeting, 2012.
  19. Monteiro, Francisca; Bernal, Vicente; Alves, Paula Marques. "Systems-level analysis of baculovirus-host interactions: From genomic to metabolomics decomposition". Paper presented in IX Metabolic Engineering Conference, 2012.
  20. Monteiro, Francisca; Bernal, Vicente; Alves, Paula Marques. "Insect cell-based Influenza vaccine bioprocess development". Paper presented in 10th PEACe Conference, 2011.
  21. Monteiro, Francisca; Carinhas, Nuno; Peixoto, Cristina; Sousa, Marcos; Carrondo, Manuel J T; Bernal, Vicente; Alves, Paula Marques. "Insect cell-based Influenza vaccine bioprocess development". Paper presented in 22nd ESACT Meeting, 2011.
Journal article
  1. Dionisio, Francisco; Domingues, Célia P. F.; Rebelo, João S.; Monteiro, Francisca; Nogueira, Teresa. "The Impact of Non-Pathogenic Bacteria on the Spread of Virulence and Resistance Genes". International Journal of Molecular Sciences 24 3 (2023): 1967. http://dx.doi.org/10.3390/ijms24031967.
    10.3390/ijms24031967
  2. Domingues, Célia P. F.; Rebelo, João S.; Monteiro, Francisca; Nogueira, Teresa; Dionisio, Francisco. "Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids". Philosophical Transactions of the Royal Society B: Biological Sciences 377 1842 (2022): http://dx.doi.org/10.1098/rstb.2020.0473.
    10.1098/rstb.2020.0473
  3. Rebelo, João S.; Domingues, Célia P. F.; Monteiro, Francisca; Nogueira, Teresa; Dionisio, Francisco. "Bacterial persistence is essential for susceptible cell survival in indirect resistance, mainly for lower cell densities". PLOS ONE 16 9 (2021): e0246500. http://dx.doi.org/10.1371/journal.pone.0246500.
    10.1371/journal.pone.0246500
  4. Domingues, Célia P. F.; Rebelo, João S.; Pothier, Joël; Monteiro, Francisca; Nogueira, Teresa; Dionisio, Francisco. "The Perfect Condition for the Rising of Superbugs: Person-to-Person Contact and Antibiotic Use Are the Key Factors Responsible for the Positive Correlation between Antibiotic Resistance Gene Diversity and Virulence Gene Diversity in Human Metagenomes". Antibiotics 10 5 (2021): 605. http://dx.doi.org/10.3390/antibiotics10050605.
    10.3390/antibiotics10050605
  5. Monteiro, Francisca; Hubmann, Georg; Takhaveev, Vakil; Vedelaar, Silke R; Norder, Justin; Hekelaar, Johan; Saldida, Joana; et al. "Measuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor". Molecular Systems Biology 15 12 (2019): http://dx.doi.org/10.15252/msb.20199071.
    Open access • Published • 10.15252/msb.20199071
  6. Carvalho, Sofia B.; Freire, João M.; Moleirinho, Mafalda G.; Monteiro, Francisca; Gaspar, Diana; Castanho, Miguel A. R. B.; Carrondo, Manuel J. T.; et al. "Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles". Bioconjugate Chemistry 27 10 (2016): 2386-2399. http://dx.doi.org/10.1021/acs.bioconjchem.6b00372.
    Published • 10.1021/acs.bioconjchem.6b00372
  7. Monteiro, Francisca; Bernal, Vicente; Alves, Paula M.. "The role of host cell physiology in the productivity of the baculovirus-insect cell system: Fluxome analysis of Trichoplusia ni and Spodoptera frugiperda cell lines". Biotechnology and Bioengineering 114 3 (2016): 674-684. http://dx.doi.org/10.1002/bit.26089.
    Published • 10.1002/bit.26089
  8. Monteiro, Francisca; Bernal, Vicente; Chaillet, Maxime; Berger, Imre; Alves, Paula M.. "Targeted supplementation design for improved production and quality of enveloped viral particles in insect cell-baculovirus expression system". Journal of Biotechnology 233 (2016): 34-41. http://dx.doi.org/10.1016/j.jbiotec.2016.06.029.
    Published • 10.1016/j.jbiotec.2016.06.029
  9. Monteiro, Francisca; Bernal, Vicente; Saelens, Xavier; Lozano, Ana B.; Bernal, Cristina; Sevilla, Angel; Carrondo, Manuel J.T.; Alves, Paula M.. "Metabolic profiling of insect cell lines: Unveiling cell line determinants behind system's productivity". Biotechnology and Bioengineering 111 4 (2013): 816-828. http://dx.doi.org/10.1002/bit.25142.
    Published • 10.1002/bit.25142
  10. Monteiro, Francisca; Carinhas, Nuno; Carrondo, Manuel J. T.; Bernal, Vicente; Alves, Paula M.. "Toward system-level understanding of baculovirus–host cell interactions: from molecular fundamental studies to large-scale proteomics approaches". Frontiers in Microbiology 3 (2012): http://dx.doi.org/10.3389/fmicb.2012.00391.
    Published • 10.3389/fmicb.2012.00391
  11. Real, Gonçalo; Monteiro, Francisca; Burger, Christa; Alves, Paula M.. "Improvement of lentiviral transfer vectors using cis-acting regulatory elements for increased gene expression". Applied Microbiology and Biotechnology 91 6 (2011): 1581-1591. http://dx.doi.org/10.1007/s00253-011-3392-2.
    Published • 10.1007/s00253-011-3392-2
  12. Carinhas, Nuno; Bernal, Vicente; Monteiro, Francisca; Carrondo, Manuel J. T.; Oliveira, Rui; Alves, Paula M.. "Optimizing baculovirus/insect cells-based bioprocesses: Combining experimental and computational tools for metabolic investigation". Abstracts of Papers of the American Chemical Society (2011): https://publons.com/wos-op/publon/9830831/.
  13. Bernal, Vicente; Monteiro, Francisca; Carinhas, Nuno; Ambrósio, Raquel; Alves, Paula M.. "An integrated analysis of enzyme activities, cofactor pools and metabolic fluxes in baculovirus-infected Spodoptera frugiperda Sf9 cells". Journal of Biotechnology 150 3 (2010): 332-342. http://dx.doi.org/10.1016/j.jbiotec.2010.09.958.
    Published • 10.1016/j.jbiotec.2010.09.958
  14. Carinhas, Nuno; Bernal, Vicente; Monteiro, Francisca; Carrondo, Manuel J.T.; Oliveira, Rui; Alves, Paula M.. "Improving baculovirus production at high cell density through manipulation of energy metabolism". Metabolic Engineering 12 1 (2010): 39-52. http://dx.doi.org/10.1016/j.ymben.2009.08.008.
    Published • 10.1016/j.ymben.2009.08.008
Thesis / Dissertation
  1. Monteiro, Francisca. "Rational design of insect cell-based vaccine production: Bridging metabolomics with mathematical tools to study virus-host interactions". PhD, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2015.
  2. Monteiro, Francisca. "The cell density effect on the baculovirus-insect cell interaction: A metabolic perspective". Master, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2009.
  3. Monteiro, Francisca. "Mutagenesis by allelic exchange in Mycobacterium sp.". Degree, Universidade de Lisboa Faculdade de Farmácia, 2008.

Other

Other output
  1. The power of dying slowly - persistence as unintentional dormancy. 2021. João S. Rebelo; Célia P. F. Domingues; Francisca Monteiro; Teresa Nogueira; Francisco Dionisio; Rebelo, João S.; Domingues, Célia P. F.; et al. https://doi.org/10.1101/2021.01.20.427471.
    10.1101/2021.01.20.427471
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/10/01 Are you sure you know why certain plasmids have the ability to transfer between bacteria? Frontiers in E3 7th Annual Meeting
Centre for Ecology, Evolution and Environment (cE3c) (Portugal)
2021/02/02 Human connections drive th evolution of metagenomes with virulence and antibiotic resistance genes ALPHY 2021: Bioinformatics and Evolutionary Genomics Meeting
CNRS, Université Grenoble Alpes (Grenoble, France)
2020/12/16 Bacterial persistence: an evolutionary mechanism or a set of erros in lucky bacteria? XVI Encontro Nacional de Biologia Evolutiva
Universidade de Aveiro (Aveiro, Portugal)
2020/12/16 Human social interactions shape the distribution of pathogenicity and antibiotic resistance genes XVI Encontro Nacional de Biologia Evolutiva
Universidade de Aveiro (Aveiro, Portugal)
2020/10/01 Understanding the correlation between virulence and antibiotic resistance genes in human metagenomes through computational simulations Frontiers in E3: 6th cE3c Anual Meeting
Centro de Ecologia, Evolução e Alterações Ambientais (cE3c) (Lisbon, Portugal)
2020/10/01 The advantage of dying slowly - the impact of persistence in indirect resistance Frontiers in E3: 6th cE3c Anual Meeting
Centro de Ecologia, Evolução e Alterações Ambientais (cE3c) (Lisbon, Portugal)
2019/09/13 Measuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor German Conference on Synthetic Biology
(Aachen, Germany)
2016/10/22 Metabolic analysis and modeling approaches to de-construct enveloped viral particles production in the Insect Cell-Baculovirus Expression System 1st ESACT Frontiers Retreat
(Lyon, France)
2016/07/05 Metabolic analysis and modeling approaches to drive enveloped viral particles production in the Insect Cell-Baculovirus Expression System 17th European Congress on Biotechnology
(Krakow, Poland)
2015/06/01 Improved production and quality of enveloped viral particles in BEVS: a host cell-driven and target-oriented approach 24th ESACT Meeting
(Barcelona, Spain)
2014/11/07 Tweaking insect cell platforms for the production of multivalent VLPs: Metabolic profiling, pathway analysis and bioprocess optimization 5th ITQB PhD Students' Meeting
(Oeiras, Portugal)
2014/07/16 Insect cell technology as a vaccine producing platform 16th European Congress on Biotechnology
(Edinburgo, United Kingdom)
2014/06/24 Insect cell technology as a vaccine producing platform Fondation Mérieux Conference on virus-like particles (VLPs) as vaccines, vectors and adjuvants,
(Annency, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/02/01 - Current Gut infections by Salmonella enterica: looking for strategies to combat them using experiments and a computer model
Co-supervisor of João Santos Rebelo
 Biologia (PhD)
Faculdade de Ciencias da Universidade de Lisboa - Center for Ecology, Evolution and Environmental Changes (CE3C), Portugal
2020/09/02 - Current Indirect resistance to antibiotics between bacteria of different species - the role of metabolism in cellular fitness
Co-supervisor of Pedro Fernando Rodrigues Costa
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/16 - 2021/02/10 Simulations in structured environment of cooperative virulence in Salmonella sp
Co-supervisor of Diogo Miguel Henriques Veloso
 Bioinformática e Biologia Computacional (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/02/17 - 2020/07/10 The role of carbon sources in indirect resistance in Salmonella enterica and Escherichia coli
Supervisor of Inês Morais
 Microbiologia Aplicada (Scientific initiation)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/23 - 2020/01/30 The role of carbon sources in indirect resistance in Salmonella Spp.
Supervisor of Marie-Ágnes Fine
 Microbiologia (Scientific initiation)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/23 - 2020/01/30 Competition between exponential and stationary phase Escherichia coli cells
Supervisor of Magda Melro
 Biologia Molecular e Genética (Scientific initiation)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/23 - 2020/01/30 The role of carbon sources in indirect resistance in Salmonella enterica and Escherichia coli
Supervisor of Ana Margarida Juliano
 Biologia Molecular e Genética (Scientific initiation)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/03/12 - 2019/06/30 R1 plasmid evolution via bottlenecks in Escherichia coli: Fitness cost of evolved versus non-evolved plasmid and host strain
Co-supervisor of Mariana Marques
 Biologia Molecular e Genética (Scientific initiation)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/03/12 - 2019/06/30 RP4 plasmid evolution via bottlenecks in Escherichia coli: Fitness cost of evolved versus non-evolved plasmid and host strain
Co-supervisor of João Pedro Costa
 Biologia Molecular e Genética (Scientific initiation)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/03/25 - 2019/06/12 Biphasic kill curve of sensitive and persistent bacteria: Programming and modelling using Mathematica
Co-supervisor of Leonor Horta
 Bioinformática (Scientific initiation)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/01/05 - 2017/08/28 Development and characterization of a flux sensor in Saccharomyces cerevisiae
Supervisor of Justin Norder
 Biomolecular Sciencies (Master)
Rijksuniversiteit Groningen Faculty of Science and Engineering, Netherlands
2017/03/20 - 2017/06/30 Fine-tuning the expression of transcriptional factor cggR to optimize a glycolytic flux-sensing system in S. cerevisiae
Supervisor of Joni Gallagher
 Life Science and Technology (Degree)
Rijksuniversiteit Groningen Faculty of Science and Engineering, Netherlands
2013/09/09 - 2014/02/17 Production of viral vectors and VLPs using the baculovirus-insect cell system
Co-supervisor of Anis Hamdi
Instituto de Biologia Experimental e Tecnológica, Portugal
2011/04/04 - 2011/07/04 Production of viral vectors and VLPs using the baculovirus-insect cell system
Co-supervisor of Rabeb Lassoued
Instituto de Biologia Experimental e Tecnológica, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/04/07 - 2016/10/21 Member of the organizing committee of the 3rd Joint Post-doc Retreat, Troia, Portugal (2016/10/19 - 2016/10/21)
Meeting (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Medicina Molecular, Portugal

Centro Champalimaud, Portugal
2011 - 2016 Workshop and Users Practical Guide for HPLC operation for ACTU members and collaborators, Oeiras, Portugal (2011 - 2016)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2013/05/02 - 2013/10/25 Member of the organizing committee 4th ITQB PhD Students Meeting, Oeiras, Portugal (2013/10/24 - 2013/10/25)
Meeting (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/05/08 - 2019/05/08 Participation in FCUL's Open Day FCUL's Open Day
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/10/17 - 2017/10/19 Participation in the EMBO Leadership and Management course for Postdocs - Acquisition of skills in teams management; good communication; healthy resolution of conflict and the management of workloads and responsibilities.
Workshop
 EMBO Leadership and Management course for Postdocs
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
2014/04/14 - 2014/04/16 Participation in the Vaccines Bioprocess Development and Commercialisation Course - Acquisition of knowledge in research, operational and regulatory challenges of the vaccine market.
Workshop
 Vaccines Bioprocess Development and Commercialization
University College London Department of Pharmaceutical and Biological Chemistry, United Kingdom

Instituto de Biologia Experimental e Tecnológica, Portugal
2012/05/21 - 2012/05/23 Participation in Metabolic Pathway Análisis Course - Acquisition of skills in essential tools of Metabolic Pathway Analysis (enzyme kinetics, stoichiometry matrix, null-space, elementary modes and conservation relations, and Flux Balance Analysis).
Workshop
 Metabolic Pathway Análisis Course
Instituto Gulbenkian de Ciência, Portugal
2011/06/06 - 2011/06/06 Participation in the Systems and Synthetic Biology MIT-Portugal 5th Annual workshop Business-Government Interface - Acquisition of skills in innovation, benefits, and business strategies within systems and synthetic biology.
Workshop
 Systems and Synthetic Biology MIT-Portugal 5th Annual workshop Business-Government Interface
Massachusetts Institute of Technology Department of Biological Engineering, United States

Universidade do Minho, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal
2011/03/26 - 2011/03/26 Volunteer at ITQB’s Open Day
Other
 ITQB’s Open Day
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010 - 2010 Volunteer at European Researchers Night, Calouste Gulbenkian Foundation, Lisbon, Portugal
Other
 European Researchers Night
Fundação Calouste Gulbenkian, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/12/05 Pseudotyped lentiviral vectors for gene therapy: impact of envelope glycoproteins
(Thesis) Main arguer
 Rodrigo José Gameiro Nogueira (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Association member

Society Organization name Role
2015 - Current European Society Animal Cell Technology
2015 - 2015 Associação dos Pós-docs do ITQB-NOVA Vice tesoureira

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/09 - Current Virologia Biologia Molecular e Genética (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09 - Current Virology course (practical and theoretical lessons) - first semester Biologia Molecular e Genética (Mestrado integrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09 - Current Seminars on bacterial persistance Microbiologia Aplicada (Mestrado integrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/10 - 2019/11 Laboratório de Microbiologia 1 - Virologia Microbiologia Aplicada (Mestrado integrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/04/27 - 2016/05/01 Practical Course of Animal Cell Culture Bioquímica para a Saúde (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2014 - Current Journal of Biotechnology (0168-1656) Elsevier
2014 - Current Applied Microbiology and Biotechnology (1432-0614) Springer-Verlag
Distinctions

Award

2017 Marie Sklodowska-Curie Actions Seal of Excellence
European Commission, Belgium
2014 Best Poster Award
Engineering Conferences International, United States

Other distinction

2016 Travel grant
European Society Animal Cell Technology, Germany
2016 Post-doc Fellowship
2015 Travel and Conference grant
European Society Animal Cell Technology, Germany
2013 Travel and Conference grant
European Society Animal Cell Technology, Germany
2012 Travel and accommodation grant
Fundação para a Ciência e a Tecnologia, Portugal
2010 PhD Fellowship