Catarina Elisa Mineiro de Melo (A21D-4E60-5462)

Curriculum Vitae

Catarina Elisa Mineiro de Melo

Catarina Elisa Mineiro de Melo completed bachelor’s degree in Biochemistry (2019/07) and master’s degree in molecular biology and Genetics (2022/03), both at the Faculty of Science, University of Lisbon. Her Master thesis focused on generating an in vitro model for congenital muscular dystrophy LAMA2-CMD using CRISPR/Cas9 technology, evaluating alterations in various cell fate pathways, and comparing them with an in vivo mouse model. Participated as Master Student Fellow in 2 projects at Instituto de Biologia Experimental e Tecnológica (iBET), involving optimizing antibody production, specifically developing strategies to identify mispairing profiles during fed-batch bioprocesses and distinct bioanalytical tools. Currently, she is a Research Technician at the Animal Cell Technology Unit of iBET's Health & Pharma Division since 2022. Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology, Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology, Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry and Natural sciences with emphasis on Biological Sciences with emphasis on Genetics and Heredity. Catarina Melo has 2 published articles in journals and participated in 12 poster communications.

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Identification

Personal identification

Full name: Catarina Elisa Mineiro de Melo

Citation names

Melo, Catarina

Author identifiers

Ciência ID: A21D-4E60-5462
ORCID iD: 0009-0008-0749-7706

Email addresses

catarina.melo@ibet.pt (Professional)
catarinamelo.98@gmail.com (Personal)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology
Natural sciences - Biological Sciences - Biochemistry
Natural sciences - Biological Sciences - Genetics and Heredity

Education

	Degree	Classification
2022/12 - 2024/04/09 Concluded	Estágio de Investigação Científica A (Pós-Graduação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	18
2022/06 - 2023/02/03 Concluded	Curso de Extensão Universitária - Estágio de Investigação Científica B (Pós-Graduação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	18
2019/09 - 2022/03/22 Concluded	Biologia Molecular e Genética (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal "The impact of Lama2-deficiency on cell cycle regulation and survival" (THESIS/DISSERTATION)	16
2016/09 - 2019/07 Concluded	Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal

Affiliation

Science

	Category Host institution	Employer
2023/12/01 - Current	Contracted Researcher (Research)	Instituto de Biologia Experimental e Tecnológica, Portugal

Projects

Contract

	Designation	Funders
2024/06/17 - 2026	Advanced bioanalytic solutions to support CAR-based products development and manufacturing challenges: from viral vectors to CAR-expressing cells PI778 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal	Ongoing
2022 - 2024	Overcoming the challenges of recombinant adenoassociated virus production to treat Muscular dystrophy PTDC/BTM-ORG/1383/2020 Research Fellow Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2022/01/01 - 2023/12/31	Bioanalytics for misparing profiling of multispecific antibodies: impact on bioprocess design PI754 Research Fellow Instituto de Biologia Experimental e Tecnológica, Portugal	Concluded

Outputs

Publications

Conference poster	Martins, Susana G; Pita, Mafalda; Melo, Catarina; Paulino-Cavaco, Cláudia; Antonini, Dario; Dayalan Naidu, Sharadha; Fonseca, Inês; et al. "Laminin-a2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms". Paper presented in 8th BenBedPhar Scientific Meeting, 2024. Melo, Catarina; Sebastião, Maria; Carvalho, Sofia B.; Gomes, Ricardo; Sousa, Pedro M. F.; GOMES-ALVES, Patrícia. "iMAB \| Bioanalytics for mispairing profiling of multispecific antibodies: impact on bioprocess design". Paper presented in iBETXplore Day, 2024. Martins, Susana G; Ribeiro, Vanessa; Melo, Catarina; Paulino-Cavaco, Cláudia; Antonini, Dario; Naidu, Sharadha Dayalan; Fonseca, Inês; et al. "Deregulation of multiple mechanisms shapes de onset of LAMA2-congenital muscular dystrophy". Paper presented in 5th Scientific Meeting of the Cost Action CA20121, 2023. Martins, Susana G; Ribeiro, Vanessa; Paulino-Cavaco, Cláudia; Melo, Catarina; Luiz, Hugo; Fonseca, Inês; Saget, Bérénice; Carlos, Ana Rita; Thorsteinsdottir, Solveig. Corresponding author: Carlos, Ana Rita. "Proliferation and differentiation defects are key events for the onset of LAMA2-congenital muscular dystrophy". Paper presented in MDA Clinical &Scientific Conference, 2023. Ribeiro, Vanessa; Martins, Susana G; Melo, Catarina; Fonseca, Inês; Murtinheira, Fernanda; Herrera, Federico; Zilhão, Rita; et al. "Laminin 211 is required for cell proliferation and myoblast differentiation in mouse models for LAMA2-congenital muscular dystrophy". Paper presented in 19th International Congress of Developmental Biology, 2022. Martins, Susana G; Melo, Catarina; Fonseca, Inês; Ribeiro, Vanessa; Saget, Berenice; Carlos, Ana Rita; Thorsteinsdottir, Solveig. "Onset of LAMA2-congenital muscular dystrophy involves cell cycle deregulation, altered redox metabolism and DNA damage". Paper presented in Myology & MITO NICE 2022, 2022. Fonseca, Inês; Lopes, Ana Sofia; Martins, Susana G; Melo, Catarina; Ribeiro, Vanessa; Marques, Luís; Luiz, Hugo; et al. "Impact of LAMA2-deficiency in cancer". Paper presented in 28th Porto Cancer Meeting - Extracellular Vesicles, Cell Communication and Cancer Time to Prick the Bubble, 2022. Martins, Susana G; Melo, Catarina; Fonseca, Inês; Ribeiro, Vanessa; Saget, Berenice; Thorsteinsdottir, Solveig; Carlos, Ana Rita. "Onset of LAMA2-congenital muscular dystrophy is characterized by defective cell proliferation and altered redox metabolism". Paper presented in Cell Symposia: Metabolites in Signaling and Disease, 2022. Ribeiro, Vanessa; Martins, Susana G; Melo, Catarina; dos Santos, Pedro G; Soares, Ana Rita; Saget, Berenice; Rodrigues, Gabriela; Carlos, Ana Rita; Thorsteinsdottir, Solveig. "Lama2-deficiency impacts on Nfix and Myogenin pathways and myoblast differentiation". Paper presented in 2022 MDA Clinical & Scientific Conference, 2022. Martins, Susana G; Melo, Catarina; Fonseca, Inês; Ribeiro, Vanessa; Saget, Berenice; Carlos, Ana Rita; Thorsteinsdottir, Solveig. "Onset of LAMA2- congenital muscular dystrophy in the mouse involves cell cycle deregulation, oxidative stress and DNA damage". Paper presented in 2022 MDA Clinical & Scientific Conference, 2022. Martins, Susana G; dos Santos, Pedro G; Cordero, G.A.; Melo, Catarina; Ribeiro, Vanessa; Antunes, Inês; Saget, Berenice; et al. "LAMA2 Congenital Muscular Dystrophy: the road to unravel the disease onset". Paper presented in Paper presented in Ciências Research Day 2021, 2021. Melo, Catarina; Saget, Berenice; Martins, Susana G; Rodrigues, Gabriela; Thorsteinsdottir, Solveig; Carlos, Ana Rita. Corresponding author: Melo, Catarina. "Lama2-deficiency impacts on mechanisms involved in cell cycle regulation and survival". Paper presented in Frontiers in E3 - 7th cE3c annual meeting 2021, 2021.
Journal article	Melo, Catarina; Carvalho, Sofia B.; Sebastião, Maria; Gomes, Ricardo; Sousa, Pedro M. F.; GOMES-ALVES, Patrícia. "Multispecific antibodies: bioanalytics for early-stage screening and characterization of mispairing profiles". Plos One (2025): Submitted Martins, Susana G; Ribeiro, Vanessa; Melo, Catarina; Paulino-Cavaco, Cláudia; Antonini, Dario; Dayalan Naidu, Sharadha; Murtinheira, Fernanda; et al. "Laminin-alpha2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms". Life Science Alliance 7 12 (2024): e202402829. https://doi.org/10.26508/lsa.202402829. Published • 10.26508/lsa.202402829
Preprint	Martins, Susana G; Ribeiro, Vanessa; Melo, Catarina; Paulino-Cavaco, Claudia; Antonini, Dario; Dayalan Naidu, Sharadha; Murtinheira, Fernanda; et al. "Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy". 2024. https://www.biorxiv.org/content/10.1101/2024.01.20.576409v1.