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My scientific journey started with a BSc in Applied Biology in 2005, followed by an MSc in Molecular Medicine and Oncology in 2008, and a PhD in Biomedical Sciences in 2014. Throughout my career, I have been conducting my research at the Portuguese Oncology Institute of Porto Research Centre (CI-IPOP), specifically at the Experimental Pathology and Therapeutics Group. This research environment allowed me to develop translational research in close collaboration with patients and clinical teams, constantly focusing on clinical issues affecting cancer patients' diagnosis and prognosis. In 2021, I was challenged to establish and lead a multidisciplinary team, comprising both young researchers and postdocs, dedicated to the discovery and validation of biomarkers from a wide range of sources, including DNA, mRNA, ncRNA, and proteins, in liquid biopsies such as blood and stool, focusing on key clinical problems, including identifying minimally invasive biomarkers for colorectal cancer screening. During my years of research, I have contributed to over 44 research papers on cancer biomarkers in different cancer models, 17 in the last 5 years with 10 as first author and 5 as senior or co-senior author. Moreover, I am the inventor of a registered patent and co-supervised 1 PhD thesis and 8 MSc dissertations. I am the supervisor/co-supervisor of 2 postdocs, 4 PhD students, and 2 MSc students, fostering the next generation of researchers. In addition, I have been involved in five projects as a researcher, currently serving as the co-PI for the FCT-granted project BioFaeC and the EU-funded project ONCOSCREEN.
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Identification

Personal identification

Full name
Luís Carlos Oliveira Lima

Citation names

  • Lima, Luís

Author identifiers

Ciência ID
9F16-0E29-D9FC
ORCID iD
0000-0001-8152-9237
Scopus Author Id
23501978900

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Proficiency (C2) Advanced (C1) Upper intermediate (B2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2014
Concluded
 Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Factores Preditivos de Resposta à Terapêutica Intravesical com BCG" (THESIS/DISSERTATION)
 Aprovado com distinção
2008/01/08
Concluded
 Mestrado em Medicina e Oncologia Molecular (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
"Apoptosis and Fas/FasL Pathway: Role of FAS and FASL Functional Polymorphisms in Prostate Cancer Development" (THESIS/DISSERTATION)
 Muito Bom
2005
Concluded
 Licencuiatura em Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Bladder Cancer" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2024/08/01 - Current Auxiliary Researcher (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2019/01/02 - 2024/07/31 Contracted Researcher (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2018/12/10 - 2019/09/10 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2009/09/14 - 2015/09/14 Invited Assistant (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Others

Category
Host institution 		Employer
2011/07/02 - Current Researcher at Experimental Patology and Therapeutics Group Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2009/01/15 - 2014/03/21 PhD student Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006/06/01 - 2011/07/01 Researcher at Molecular Oncology Group Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2006/01/02 - 2008/01/08 Master student in Molecular Medicine and Oncology Universidade do Porto Faculdade de Medicina, Portugal
2004/07/01 - 2005/11/30 Applied Biology graduation intership Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Projects

Grant

Designation Funders
2025/01 - 2029/12 Unveiling Transcriptome Landscape to Enhance Colorectal Cancer Screening: An Integrated Approach
2024.04511.BD
Supervisor
2023/12/27 - 2027/12/26 An Integrative Approach for Biomarker Discovery in Colorectal Cancer: From Screening to Therapeutics
CI-IPOP-776_6_BD
Supervisor
Ongoing
2023 - 2027 Challenging invasive fungal infections: Development of innovative electrochemical nanogenosensors to detect Aspergillus spp, Candida spp, and Zygomycetes
FCT 2023.05159.BDANA
Supervisor
Ongoing
2022/01/01 - 2025/12/31 Introducing molecular analysis of Circulating Tumour Cells in the clinic: Their significance in clonal evolution and immune escape in gastrointestinal cancers
2021.05593.BD
Supervisor
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2025/01 - 2025/12 Enhancing Colorectal Cancer Screening through Machine Learning-Based Biomarker Identification
LPCCN
Supervisor
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Ongoing
2020/09/01 - 2023/08/31 Glycan-based solutions for improving metastatic colorectal cancer patients’ management.
2020.09394.BD
Supervisor
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2021/12/31 The Role of Circulating Tumour Cells in Colorectal Cancer Liver Metastasis Management
LPCC-NRN 2022
Supervisor
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
Concluded
2018/03 - 2018/12 Circulating tumor cells in gastrointestinal cancers: role and development of tools to improve cancer management and individualized testing of treatment susceptibility
SFRH/BPD/101827/2014
Post-doc Fellow
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2015/03 - 2018/03 Exploring glycobiomarkers as targets for bladder cancer chemoresistant cells
SFRH/BPD/101827/2014
Post-doc Fellow
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/03 - 2013/03 Predictive Factors of Response to Intravesical Therapy with BCG
SFRH/BD/43399/2008
PhD Student Fellow
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/01/01 - 2026/12/31 ONCOSCREEN: A European “shield” against colorectal cancer based on novel, more precise and affordable risk-based screening methods and viable policy pathways
101097036
Co-Principal Investigator (Co-PI)
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 European Commission
Ongoing
2022/01/01 - 2024/12/01 RESOLVE: Rational Design of Multivalent Glycocode-Inspired Nanovaccines for Gastric Cancer Immunotherapy
PTDC/MED-OUT/2512/2021
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/02/01 - 2024/07/31 BioFaeC: Novel faecal biomarkers for early detection of precancerous lesions and cancer - Improving the current model for colorectal cancer screening
2022.09051.PTDC
Co-Principal Investigator (Co-PI)
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Centro de Investigação do Instituto Português de Oncologia do Porto
UID/DTP/00776/2019
UID/DTP/04750/2019
UIDB/04750/2020
UIDB/00776/2020
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal

Universidade do Porto Unidade de Investigação em Epidemiologia, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 776 - 2011-2012
PEst-OE/SAU/UI0776/2011
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2020 - Current IDEAR: Neoadjuvant Immunotherapy with Durvalumab (MEDI4736) in Non-Surgical Early Stage or Located Advanced Non-Small Cell Lung Cancer (NSCLC) followed by Radical Radiotherapy or Chemotherapy (Phase II, single arm, clinical trial)¿.
PI-97
Researcher
Ongoing
2022/01/01 - 2025/12/31 RISE: Health Research Network: From Lab to Community Health
LA/P/0053/2020
Researcher
Fundação para a Ciência e a Tecnologia, Portugal
Ongoing
2021 - 2023 TeamUp4Cancer: Porto Comprehensive Cancer Center
NORTE-01-0145- FEDER-072678
Researcher
2017 - 2020 ESTIMA: Early-stage cancer treatment, driven by context of molecular imaging
NORTE-01-0145-FEDER-000027
Researcher
European Regional Development Fund, Belgium
Concluded
2013 - 2015 Identification of bladder cancer stem cell glycobiomarkers based on chemotherapy sorting approach
Bolsa de Investigação APU/PFIZER 2013
Researcher
Associação Portuguesa de Urologia, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Lima, Luís. "Tumores da Bexiga – Genética". In Tumores Malignos do tracto génito-urinário. F. Calais da Silva – Grupo Português Génito-Urinário, 2016.
    Published
  2. Lima, Luís. "Tumores da Pelvis Renal e do Ureter – Genética e Biologia Molecular". In Tumores Malignos do tracto génito-urinário. F. Calais da Silva – Grupo Português Génito-Urinário, 2016.
    Published
Conference abstract
  1. Catarina, Lopes; Pereira, Carina; Lima, Luís; Medeiros, Rui; Dinis-Ribeiro, Mário. "Gene espression characterization of the prostaglandin E2 pathway in gastric cancer development - the aspirin as an opportunity for prevention?". Paper presented in YES (Young European Scientist) Meeting 2019, Porto, 2019.
    Published
  2. Pereira, Ana; Ribeiro, Joana; Queirós, Sara; Esteves, Marlene E.; Lima, Luís; Sousa, Hugo; Marcos-Pinto, Ricardo; et al. Corresponding author: Pereira, Ana. "Su1939 Influence of Genetic Polymorphisms in Prostaglandin E2 (PGE2) Pathway on mRNA Expression of COX-2, Hpgd, Abcc4 and Slco2a1 Genes in Colorectal Tumors". Paper presented in DDW 2015, 2015.
    Published • 10.1016/s0016-5085(15)31868-0
  3. Palmeira, Carlos; Santos, Lúcio; Lameiras, Catarina; Amaro, Teresina; Lima, Luís; Lopes, Carlos; Oliveira, Paula A.; Koch, Alberto. "CIS associado à Carcinogénese em Campo e Instabilidade Genética na Mucosa Urotelial da Bexiga". Paper presented in Congresso da Associação Portuguesa de urologia, Torres Vedras, 2009.
    Published
Conference paper
  1. Santos, Marlene; Carvalho, Serafim; Lima, Luís; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, Diana; et al. "Role of pharmacogenomics in predicting antidepressant response and individualizing therapy". 2015.
  2. Santos, Marlene; Carvalho, Serafim; Lima, Luís; Nogueira, Augusto; Assis, Joana; Mota-Pereira, Jorge; Pimentel, Paulo; et al. "Influence of common ABCB1 genetic polymorphisms in the risk of Major Depressive Desorder and ntidepressant treatment phenotypes". 2013.
Conference poster
  1. Loureiro, Susana; Santos, Daniela A. R.; Caldevilla, Renato; Eiras, Mariana; Soares, Janine; Lara Santos, Lúcio; Dinis-Ribeiro, Mario; Lima, Luís. "Elevate Stool MMP9 Levels: A Potential Screening Tool for Colorectal Cancer". Paper presented in 2nd Young Researchers' Day, 2024.
  2. Soares, Janine; Santos, Daniela A. R.; Eiras, Mariana; Lara Santos, Lúcio; Dinis-Ribeiro, Mario; Brandão, Andreia; Lima, Luís. "Enhancing Colorectal Cancer Screening through Machine Learning-Based Biomarker Identification". Paper presented in 2nd Young Researchers' Day, 2024.
  3. Pinto, Debora; Santos, Daniela A. R.; Eiras, Mariana; Soares, Janine; Caldevilla, Renato; Loureiro, Susana; Lara Santos, Lúcio; Dinis-Ribeiro, Mario; Lima, Luís. "Enhancing Colorectal Cancer Screening: Identifying Promising Biomarkers for Early Detection". Paper presented in 2nd Young Researchers' Day, 2024.
  4. Eiras, Mariana; Pinto, Débora; Santos, Daniela A. R.; Caldevilla, Renato; Loureiro, Susana; Soares, Janine; Lara Santos, Lúcio; Dinis-Ribeiro, Mario; Lima, Luís. "Unravelling the potential of PRDX6 and NAA60 as biomarkers for early diagnosis of colorectal cancer". Paper presented in 2nd Young Researchers' Day, 2024.
  5. Carneiro, Adriana; Piairo, Paulina; Santos, Daniela A. R.; Eiras, Mariana; Mariño, Rodrigo; Lara Santos, Lúcio; Dieguez, Lorena; Lima, Luís. "Isolation and Characterization of Circulating Tumour Cells and Clusters in Gastrointestinal Cancer: Towards Non-invasive Biomarkers for Prognosis". Paper presented in 2nd Young Researchers' Day, 2024.
  6. Matos, Leonardo; Santos, Daniela A. R.; Eiras, Mariana; Soares, Janine; Caldevilla, Renato; Loureiro, Susana; Santos, Lúcio Lara; Dinis-Ribeiro, M.; Lima, Luís. "Blood Biomarkers was a promising approach for Early Colorectal Cancer". Paper presented in 2nd Young Researchers' Day, 2024.
  7. Santos, Daniela A. R.; Eiras, Mariana; Pinto, Debora; Loureiro, Susana; Caldevilla, Renato; Soares, Janine; Santos, Marlene; et al. "MicroRNAs in the Early Detection of Colorectal Lesions: A Promising Solution for Improvement the Screening?". Paper presented in 2nd Young Researchers' Day, 2024.
  8. Carneiro, Adriana; Piairo, Paulina; Pesqueira, Tamagno; Mariño, Rodrigo; Lima, Luís; Dieguez, Lorena. "3D Culture Model for CTC clusters: Understanding the crosstalk between cancer cells and immune cells". Paper presented in III Jornadas IBEROS+, 2024.
  9. Santos, Daniela A. R.; Eiras, Mariana; Pereira, Carina; Santos, Marlene; Santos, Lúcio Lara; Dinis-Ribeiro, Mario; Lima, Luís. "Clinical Value of Fecal MicroRNA Combination for Precancerous and Cancerous Colorectal Lesions Detection". Paper presented in UEG Week 2024, 2024.
  10. Eiras, Mariana; Santos, Daniela A. R.; Lara Santos, Lúcio; Dinis-Ribeiro, Mario; Lima, Luís. "Sialil-Tn Fecal – Potencial Biomarcador no Rastreio de Cancro Colorretal". Paper presented in 6º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), Porto, Portugal, 2024, 2024.
  11. Santos, Daniela A. R.; Eiras, Mariana; Pereira, Carina; Santos, Marlene; Lara Santos, Lúcio; Dinis-Ribeiro, Mario; Lima, Luís. "MicroRNAs fecais e a sua aplicação clínica na deteção de lesões colorretais pré-malignas e malignas". Paper presented in 6.º Encontro Nacional de Jovens Investigadores em Oncologia, 2024, 2024.
  12. Carneiro, Adriana; Sampaio, Ana; Piairo, Paulina; Fraga, Joana; Lima, Luís; Dieguez, Lorena. "PD-L1 assessment in circulating tumour cells from NSCLC patients". Paper presented in IX Liquid Biopsy Symposium, 2024.
  13. Caldevilla, Renato; Eiras, Mariana; Santos, Daniela A. R.; Pinto, Débora; Loureiro, Susana; Soares, Janine; Videira, Paula; et al. "L2A5 Monoclonal Antibody as a Tool for Non-invasive Colorectal Cancer Screening in Stool". Paper presented in 2nd Young Researchers' Day, 2024.
  14. Carneiro, Adriana; Piairo, Paulina; Lima, Luís; Dieguez, Lorena. "CTC Clusters: Understanding the crosstalk between cancer cells and immune cells". Paper presented in VII Annual Meeting CINBIO, 2024.
  15. Carneiro, Adriana; Piairo, Paulina; Matos, Beatriz; Santos, Daniela A. R.; Palmeira, Carlos; Diéguez, Lorena; Lima, Luís. "Detection and validation of Circulating Tumour Cells in Gastrointestinal Malignancie". Paper presented in 1st Young Researchers Day, 2023.
  16. Santos, Daniela A. R.; Oliveira, Beatriz ; Almeida, João; Gaiteiro, Cristiana; Lúcio Lara Santos; Mário Dinis-Ribeiro; Lima, Luís. "Sialyl-Tn in Stool – A Potential Non-invasive Tool for Colorectal Cancer Screening". Paper presented in 1st Young Researchers’ Day, 2023.
  17. Santos, Daniela A. R.; Gaiteiro, Cristiana; Santos, Marlene ; Lúcio Lara Santos; Mário Dinis-Ribeiro; Lima, Luís. "MicroRNAs: Potenciais Biomarcadores para a Deteção Precoce de Cancro Colorretal". Paper presented in Encontro Nacional de Jovens Investigadores em Oncologia 2023, 2023.
  18. Santos, Daniela A. R.; Gateiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, Luís. "MicroRNAs Biomarkers for Early Screening of Colorectal Cancer". Paper presented in I Jornadas do CISA, 2023.
  19. Carneiro, Adriana; Piairo, Paulina; Lima, Luís; Diéguez, Lorena. "Enhancing CTC Detection and Phenotyping: A High Specificity Double-Exclusion Assay.". Paper presented in 13th International Symposium on Minimal Cancer, 2023.
  20. Carneiro, Adriana; Piairo, Paulina; Lima, Luís; Diéguez, Lorena. "High Specificity Assay for CTC Detection and Phenotyping: Double-Exclusion Criteria". Paper presented in VIII Liquid Biopsy Symposium, 2023.
  21. Gaspar, CF; Sousa, H; Mainoli, B; Lima, Luís; Palmeira, Carlos; Martins, G; Oliveira, M; et al. "Neoadjuvant durvalumab in Non-Surgical Early Stage/Locally Advanced NSCLC followed by Radical RT/CRT - Study Concept of a Phase Ib/II Investigator Initiated Clinical Trial - IDEAR". Paper presented in EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY CONGRESS (ESMO), 2022.
  22. Carneiro, Adriana; Piairo, Paulina; Abalo, A; Herrero, C; Oliveira, B; Lima, Luís; Alconada, L; Muinelo-Romay, Laura; Diéguez, Lorena. "Tailoring Microfluidic Immunoassays for Detection and Characterization of Circulating Tumour Cells in Breast, Colorectal and Lung Cancer". Paper presented in V Annual Meeting CINBIO, 2022.
  23. Carneiro, Adriana; Piairo, Paulina; Teixeira, Alexandra; Ferreira, Dylan; Cotton, Sofia; Rodrigues, Carolina; Chícharo, Alexandre; et al. "Microfluidic-based Isolation of Circulating Tumour Cells in Gastrointestinal Cancers". Paper presented in VII Liquid Biopsy Symposium, 2022.
  24. Carneiro, Adriana; Piairo, Paulina; Ferreira, Dylan; Cotton, Sofia; Rodrigues, C; Chícharo, Alexandre; Abalde-Cela, Sara; Lima, Luís; Dieguez, Lorena. "Microfluidic-based Isolation of Circulating Tumour Cells in Gastrointestinal Cancers.". Paper presented in VII Simposium Biopsia Líquida, 2022.
  25. Carneiro, Adriana; Piairo, Paulina; Teixeira, Alexandra; Chícharo, Alexandre; Abalde-Cela, Sara; Lima, Luís; Diéguez, Lorena. "Microfluidic-based Isolation of Gastrointestinal Circulating Tumour Cells". Paper presented in EuroNanoForum Conference, 2021.
  26. Carneiro, Adriana; Piairo, Paulina; Lima, Luís; Diéguez, Lorena. "Optimization of a Microfluidic Device for the Isolation and Enumeration of Circulating Tumour Cells in Colorectal Cancer". Paper presented in Cancer Biology: From Basic to Translational Research Conferece, 2020.
  27. Carneiro, Adriana; Piairo, Paulina; Lima, Luís; Diéguez, Lorena. "Otimização de um dispositivo de microfluídica para o isolamento e enumeração de células tumorais circulantes em cancro colorectal". Paper presented in 2º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), Porto, Portugal, 2020, 2020.
  28. Peixoto, Andreia; Fernandes, Elisabete; Gaiteiro, Cristiana; Lima, Luís; Azevedo, Rita; Soares, Janine; Cotton, Sofia; et al. "Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation". Paper presented in 29th International Carbohydrate Symposium (ICS 2018) by Peixoto A, 2018.
  29. Santos, M; Carvalho, S; Lima, Luís; Mota-Pereira, J.; Pimentel, P; Maia, D; Correia, D; et al. "Polimorfismos genéticos do gene abcb1 e fenótipos de resposta à Terapêutica com antidepressores: resultados de uma coorte de doentes portugueses com depressão". Paper presented in Reunião Internacional da Rede Académica das Ciências da Saúde, 2017.
  30. Fernandes, E; Ferreira, JA; Lima, Luís; Parreira, B; Peixoto, A; Tavares, A; Afonso, LP; et al. "Abnormal glycosylation in Borrmann type IV gastric cancer: insight for guided therapeutics". Paper presented in Encontros da Primavera, 2015.
  31. Ferreira, JA; Costa, C; Pereira, S; Lima, Luís; Peixoto, A; Fernandes, E; Neves, D; et al. "Abnormal protein glycosylation and activated PI3K/Akt/mTOR pathway: insights for bladder cancer prognosis and targeted therapeutics". Paper presented in Encontros da Primavera, 2015.
  32. Lima, Luís; Dias, Cruz, R; Freitas, R; Oliveira, D; Tavares, A; Ferreira, JA; Medeiros, R; Lara Santos, Lúcio. "The role of functional polymorphism in immune response genes as biomarkers of BCG immunotherapy outcome in bladder cancer: Establishment of a predictive profile". Paper presented in 29th Annual EAU Congress Stockholm, 2014.
  33. Lima, Luís; Oliveira, D; Tavares, A; Amaro, T; Cruz, R; Oliveira, MJ; Ferreira, JA; Lara Santos, Lúcio. "High counts of stroma-restricted M2-polarized macrophages are associated with BCG immunotherapy failure in bladder cancer.". Paper presented in Second ESPT Conference: Pharmacogenomics: from cell to clinic, 2013.
  34. Lima, Luís; Oliveira, D; Cruz, R; Ferreira, JA; Medeiros, R; Lara Santos, Lúcio. "The role of cytokine and chemokine polymorphisms in BCG immunotherapy outcome". Paper presented in Second ESPT Conference: Pharmacogenomics: from cell to clinic, 2013.
  35. Santos, M; Carvalho, S; Lima, Luís; Nogueira, A; Assis, J; Mota-Pereira, J.; Pimentel, P; et al. "FAS -670A>G genetic polymorphism is associated with Treatment Resistant Depression". Paper presented in Second ESPT Conference: Pharmacogenomics: from cell to clinic, 2013.
  36. Santos, M; Carvalho, S; Lima, Luís; Nogueira, A; Assis, J; Mota-Pereira, J.; Pimentel, P; et al. "Influence of common ABCB1 genetic polymorphisms in the risk of Major Depressive Disorder and antidepressant treatment phenotypes". Paper presented in Second ESPT Conference: Pharmacogenomics: from cell to clinic, 2013.
  37. Ferreira, JA; Lima, Luís; Silva, M; Miranda, A; Severino, PF; Pereira, S; Fernandes, E; et al. "Tumour associated carbohydrate antigens sialyl-Tn and sialyl-6-T as predictors of BCG immunotherapy response in bladder cancer". Paper presented in Encontros de Primavera de Oncologia, 2013.
  38. Lima, Luís; Santos, M; Morais, A; Medeiros, R; Lara Santos, Lúcio. "FASL-844CC genotype as a predictive factor for poor response to bacillus Calmette-Guerin immunotherapy". Paper presented in World Congress of Pharmacy and Pharmaceutical Sciences, 2012.
  39. Vitorino, R; Ferreira, JA; Machado, D; Vieira, I; Evtyugin, D; Coimbra, MA; Lima, Luís; et al. "Can mucin glycosylation in saliva reflect oral malignant transformations? A preliminary approach". Paper presented in 2nd International Congress on Analytical Proteomics, 2011.
  40. Ferreira, JA; Vieira, I; Pereira, S; Costa, C; Freire, P; Lima, Luís; Amaro, T; et al. "Biomarker value of urine glycoproteins expressing cancer associated sialyl-Tn (CA 74-2) epitopes for the surveillance of urothelial carcinomas". Paper presented in 2nd International Congress on Analytical Proteomics, 2011.
  41. Lima, Luís; Pereira, D; Gomes, AM; Pinto, D; Medeiros, R. "Association between FAS-670A/G polymorphism and ovarian cancer development". Paper presented in 21st European Association for Cancer Research conference, EACR21, 2010.
  42. Lima, Luís; Gomes, AM; Ribeiro, R; Fraga, A; Pina, F; Lobo, F; Calais-da-Silva, F; Medeiros, R. "The Role of Fas/FasL Apoptotic System in Prostate Cancer Hormone-Resistance". Paper presented in 2º CURy – The World Congress on Controversies in Urology, 2009.
  43. Lima, Luís; Coelho, A; Gomes, M; Silva, J; Magalhães, S; Medeiros, R; Lara Santos, Lúcio. "Bladder Cancer and BCG Immunotherapy: The Role of Immunological Th2-subset (IL10-592A/C polymorphism) in Treatment Failure". Paper presented in 2º CURy – The World Congress on Controversies in Urology, 2009.
  44. Lima, Luís; Gomes, AM; Ribeiro, R; Fraga, A; Pina, F; Lobo, F; Calais-da-Silva, F; Medeiros, R. "Prostate cancer and apoptosis: An insight of FAS-670A/G polymorphism role in tumor development". Paper presented in Joint ECCO 15-34th ESMO Multidisciplinary Congress, 2009.
  45. Lima, Luís; Gomes, M; Pinto, D; Medeiros, R. "Associação entre o polimorfismo Fas–670A/G e o desenvolvimento do cancro do ovário". Paper presented in 11º Congresso da Nacional de Oncologia, 2008.
  46. Lima, Luís; Morais, A; Lobo, F; Calais-da-Silva, FM; Medeiros, R. "Associação entre o polimorfismo FAS -670 A/G e o desenvolvimento do cancro da Próstata". Paper presented in 12ª Jornadas de Oncologia Médica, 2007.
  47. Lima, Luís; Morais, A; Medeiros, R; Lara Santos, Lúcio. "Estudo preliminar do papel da apoptose na resposta à imunoterapia com BCG: O papel dos polimorfismos". Paper presented in 12º Jornadas de Oncologia Médica, 2007.
  48. Lima, Luís; Morais, A; Lobo, F; Calais-da-Silva, FM; Calais-da-Silva, F.E.; Lara Santos, Lúcio; Medeiros, R. "Apoptosis in Bladder and prostate cancer: The role of FAS and FASL polymorphisms". Paper presented in ECCO 14, 2007.
  49. Pinho, T; Pereira, M; Lima, Luís; Costa, C; Pereira, S; Palmeira, C; Lara Santos, Lúcio. "Estudo Preliminar de Linfangiogénese no Carcinoma do Lábio". Paper presented in 4º Simpósio de Análises Clínicas - Universidade Fernando Pessoa, 2006.
  50. Lima, Luís; Lameiras, C; Sampaio, P; Veiga, I; Lara Santos, Lúcio. "Estudo preliminar das alterações do cromossoma 9 no tecido tumoral, mucosa adjacente e à distância no carcinoma urotelial da bexiga". Paper presented in 10º Congresso da Nacional de Oncologia, 2005.
Journal article
  1. Alves, Ângela; Ferreira, Mariana; Eiras, Mariana; Lima, Luís; Medeiros, Rui; Teixeira, Ana Luísa; Dias, Francisca. "Exosome-derived hsa-miR-200c-3p, hsa-miR-25-3p and hsa-miR-301a-3p as potential biomarkers and therapeutic targets for restoration of PTEN expression in clear cell renal cell carcinoma". International Journal of Biological Macromolecules 302 (2025): 140607. https://doi.org/10.1016/j.ijbiomac.2025.140607.
    10.1016/j.ijbiomac.2025.140607
  2. Caldevilla, Renato; Eiras, Mariana; Santos, Daniela A. R.; Almeida, João; Oliveira, Beatriz; Loureiro, Susana; Soares, Janine; et al. "Advancing Non-Invasive Colorectal Cancer Screening: Exploring the Potential of Monoclonal Antibody L2A5". International Journal of Molecular Sciences 26 7 (2025): 3070. https://doi.org/10.3390/ijms26073070.
    10.3390/ijms26073070
  3. Peixoto, Andreia; Ferreira, Dylan; Miranda, Andreia; Relvas-Santos, Marta; Freitas, Rui; Veth, Tim S.; Brandão, Andreia; et al. "Multilevel plasticity and altered glycosylation drive aggressiveness in hypoxic and glucose-deprived bladder cancer cells". iScience 28 2 (2025): 111758. https://doi.org/10.1016/j.isci.2025.111758.
    10.1016/j.isci.2025.111758
  4. Santos, Marlene; Lima, Luis; Carvalho, Serafim; Brandão, Andreia; Barroso, Fátima; Cruz, Agostinho; Medeiros, Rui. "ABCB1 C1236T, G2677TA and C3435T Genetic Polymorphisms and Antidepressant Response Phenotypes: Results from a Portuguese Major Depressive Disorder Cohort". International Journal of Molecular Sciences 25 10 (2024): 5112. http://dx.doi.org/10.3390/ijms25105112.
    10.3390/ijms25105112
  5. Soares, Janine; Eiras, Mariana; Ferreira, Dylan; Santos, Daniela A. R.; Relvas-Santos, Marta; Santos, Beatriz; Gonçalves, Martina; et al. "Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer". International Journal of Molecular Sciences 25 7 (2024): 3722. http://dx.doi.org/10.3390/ijms25073722.
    10.3390/ijms25073722
  6. Ferreira, Eduardo; Ferreira, Dylan; Relvas-Santos, Marta; Freitas, Rui; Soares, Janine; Azevedo, Rita; Afonso, Luís Pedro; et al. "Aberrantly Glycosylated GLUT1 as a Poor Prognosis Marker in Aggressive Bladder Cancer". International Journal of Molecular Sciences 25 6 (2024): 3462. http://dx.doi.org/10.3390/ijms25063462.
    Accepted • 10.3390/ijms25063462
  7. Carneiro, Adriana; Piairo, Paulina; Matos, Beatriz; Santos, Daniela A.R.; Palmeira, Carlos; Santos, Lúcio Lara; Diéguez, Lorena; Lima, Luís. "Minimizing false positives for CTC identification". Analytica Chimica Acta 1288 (2024): 342165. http://dx.doi.org/10.1016/j.aca.2023.342165.
    10.1016/j.aca.2023.342165
  8. Santos, Daniela A. R.; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, Luís. "MicroRNA Biomarkers as Promising Tools for Early Colorectal Cancer Screening—A Comprehensive Review". International Journal of Molecular Sciences 24 13 (2023): 11023. http://dx.doi.org/10.3390/ijms241311023.
    10.3390/ijms241311023
  9. Poças, Juliana; Marques, Catarina; Gomes, Catarina; Otake, Andreia Hanada; Pinto, Filipe; Ferreira, Mariana; Silva, Tiago; et al. "Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival". Proceedings of the National Academy of Sciences 120 20 (2023): http://dx.doi.org/10.1073/pnas.2214853120.
    10.1073/pnas.2214853120
  10. Santos, Marlene; Lima, Luis; Carvalho, Serafim; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, Diana; et al. "The Impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and SYN1 Genetic Polymorphisms in Antidepressant Treatment Response Phenotypes". International Journal of Molecular Sciences 24 7 (2023): 6758. http://dx.doi.org/10.3390/ijms24076758.
    10.3390/ijms24076758
  11. Carneiro, Adriana; Piairo, Paulina; Teixeira, Alexandra; Ferreira, Dylan; Cotton, Sofia; Rodrigues, Carolina; Chícharo, Alexandre; et al. "Discriminating Epithelial to Mesenchymal Transition Phenotypes in Circulating Tumor Cells Isolated from Advanced Gastrointestinal Cancer Patients". Cells 11 3 (2022): 376. http://dx.doi.org/10.3390/cells11030376.
    10.3390/cells11030376
  12. Gaiteiro, Cristiana; Soares, Janine; Relvas-Santos, Marta; Peixoto, Andreia; Ferreira, Dylan; Paulo, Paula; Brandão, Andreia; et al. Corresponding author: Ferreira, José Alexandre. "Glycoproteogenomics characterizes the CD44 splicing code associate with bladder cancer invasion". Theranostics (2022):
    Accepted • 10.7150/thno.67409
  13. Peixoto, Andreia; Ferreira, Dylan; Azevedo, Rita; Freitas, Rui; Fernandes, Elisabete; Relvas-Santos, Marta; Gaiteiro, Cristiana; et al. "Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer". Journal of Experimental & Clinical Cancer Research 40 1 (2021): http://dx.doi.org/10.1186/s13046-021-01988-6.
    10.1186/s13046-021-01988-6
  14. Cotton, Sofia; Ferreira, Dylan; Soares, Janine; Peixoto, Andreia; Relvas-Santos, Marta; Azevedo, Rita; Piairo, Paulina; et al. "Target Score—A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness". International Journal of Molecular Sciences 22 4 (2021): 1664. http://dx.doi.org/10.3390/ijms22041664.
    10.3390/ijms22041664
  15. Wu, Lei; Teixeira, Alexandra; Garrido-Maestu, Alejandro; Muinelo-Romay, Laura; Lima, Luis; Santos, Lúcio Lara; Prado, Marta; Diéguez, Lorena. "Profiling DNA mutation patterns by SERS fingerprinting for supervised cancer classification". Biosensors and Bioelectronics 165 (2020): 112392. http://dx.doi.org/10.1016/j.bios.2020.112392.
    10.1016/j.bios.2020.112392
  16. Carvalho, Sandra; Abreu, Catarina M.; Ferreira, Dylan; Lima, Luís; Ferreira, José A.; Santos, Lúcio L.; Ribeiro, Ricardo; et al. "Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies". Frontiers in Oncology 10 (2020): http://dx.doi.org/10.3389/fonc.2020.01774.
    10.3389/fonc.2020.01774
  17. Carneiro, Adriana; PIAIRO, PAULINA; Diéguez, Lorena; Lima, Luís. "Circulating Tumor Cells: A Portuguese Contribution Towards Precision Medicine". Revista Portuguesa de Cirurgia 47 (2020): 23-29. http://dx.doi.org/10.34635/rpc.806.
    Open access • Published • 10.34635/rpc.806
  18. Batista, Rui; Lima, Luís; Vinagre, João; Pinto, Vasco; Lyra, Joana; Máximo, Valdemar; Santos, Lúcio; Soares, Paula. "TERT Promoter Mutation as a Potential Predictive Biomarker in BCG-Treated Bladder Cancer Patients". International Journal of Molecular Sciences 21 3 (2020): 947. http://dx.doi.org/10.3390/ijms21030947.
    10.3390/ijms21030947
  19. Neves, Manuel; Azevedo, Rita; Lima, Luís; Oliveira, Marta I.; Peixoto, Andreia; Ferreira, Dylan; Soares, Janine; et al. "Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications". New Biotechnology 49 (2019): 77-87. http://dx.doi.org/10.1016/j.nbt.2018.09.004.
    10.1016/j.nbt.2018.09.004
  20. Loureiro, Liliana R.; Sousa, Diana P.; Ferreira, Dylan; Chai, Wengang; Lima, Luís; Pereira, Carina; Lopes, Carla B.; et al. "Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-30421-w.
    10.1038/s41598-018-30421-w
  21. Azevedo, Rita; Soares, Janine; Gaiteiro, Cristiana; Peixoto, Andreia; Lima, Luís; Ferreira, Dylan; Relvas-Santos, Marta; et al. "Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in bladder cancer". Talanta 184 (2018): 347-355. http://dx.doi.org/10.1016/j.talanta.2018.03.028.
    10.1016/j.talanta.2018.03.028
  22. Azevedo, Rita; Gaiteiro, Cristiana; Peixoto, Andreia; Relvas-Santos, Marta; Lima, Luís; Santos, Lúcio Lara; Ferreira, José Alexandre. "CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications". Clinical Proteomics 15 1 (2018): http://dx.doi.org/10.1186/s12014-018-9198-9.
    10.1186/s12014-018-9198-9
  23. Azevedo, Rita; Soares, Janine; Peixoto, Andreia; Cotton, Sofia; Lima, Luís; Santos, Lúcio Lara; Ferreira, José Alexandre. "Circulating tumor cells in bladder cancer: Emerging technologies and clinical implications foreseeing precision oncology". Urologic Oncology: Seminars and Original Investigations 36 5 (2018): 221-236. http://dx.doi.org/10.1016/j.urolonc.2018.02.004.
    10.1016/j.urolonc.2018.02.004
  24. Lima, Luís; Neves, Manuel; Oliveira, Marta I.; Dieguez, Lorena; Freitas, Rui; Azevedo, Rita; Gaiteiro, Cristiana; et al. "Sialyl-Tn identifies muscle-invasive bladder cancer basal and luminal subtypes facing decreased survival, being expressed by circulating tumor cells and metastases". Urologic Oncology: Seminars and Original Investigations 35 12 (2017): 675.e1-675.e8. http://dx.doi.org/10.1016/j.urolonc.2017.08.012.
    10.1016/j.urolonc.2017.08.012
  25. Azevedo, Rita; Peixoto, Andreia; Gaiteiro, Cristiana; Fernandes, Elisabete; Neves, Manuel; Lima, Luís; Santos, Lúcio Lara; Ferreira, José Alexandre. "Over forty years of bladder cancer glycobiology: Where do glycans stand facing precision oncology?". Oncotarget 8 53 (2017): http://dx.doi.org/10.18632/oncotarget.19433.
    10.18632/oncotarget.19433
  26. Cotton, S.; Azevedo, R.; Gaiteiro, C.; Ferreira, D.; Lima, L.; Peixoto, A.; Fernandes, E.; et al. "Targeted O-glycoproteomics explored increased sialylation and identified MUC16 as a poor prognosis biomarker in advanced-stage bladder tumours". Molecular Oncology 11 8 (2017): 895-912. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026673810&partnerID=MN8TOARS.
    10.1002/1878-0261.12035
  27. Carvalho, S.; Santos, M.; Lima, L.; Mota-Pereira, J.; Pimentel, P.; Maia, D.; Correia, D.; et al. "IL6-174G > C genetic polymorphism influences antidepressant treatment outcome". Nordic Journal of Psychiatry 71 2 (2017): 158-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992753683&partnerID=MN8TOARS.
    10.1080/08039488.2016.1242650
  28. Lima, L.; Gaiteiro, C.; Peixoto, A.; Soares, J.; Neves, M.; Santos, L.L.; Ferreira, J.A.. "Reference genes for addressing gene expression of bladder cancer cell models under hypoxia: A step towards transcriptomic studies". PLoS ONE 11 11 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84994718346&partnerID=MN8TOARS.
    10.1371/journal.pone.0166120
  29. Peixoto, A.; Fernandes, E.; Gaiteiro, C.; Lima, L.; Azevedo, R.; Soares, J.; Cotton, S.; et al. "Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension". Oncotarget 7 39 (2016): 63138-63157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994050563&partnerID=MN8TOARS.
    10.18632/oncotarget.11257
  30. Santos, M.; Carvalho, S.; Lima, L.; Mota-Pereira, J.; Pimentel, P.; Maia, D.; Correia, D.; et al. "The role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report". Neuroscience Letters 622 (2016): 107-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-84967185449&partnerID=MN8TOARS.
    10.1016/j.neulet.2016.03.026
  31. Santos M; Carvalho S; Lima L; Mota-Pereira J; Pimentel P; Maia D; Correia D; et al. "FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression.". (2015): http://europepmc.org/abstract/med/26186532.
    10.1016/j.jad.2015.06.027
  32. Lima, L.; Oliveira, D.; Ferreira, J.A.; Tavares, A.; Cruz, R.; Medeiros, R.; Santos, L.. "The role of functional polymorphisms in immune response genes as biomarkers of bacille Calmette-Guérin (BCG) immunotherapy outcome in bladder cancer: establishment of a predictive profile in a Southern Europe population". BJU International (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929431572&partnerID=MN8TOARS.
    10.1111/bju.12844
  33. Fernandes, E.; Ferreira, J.A.; Andreia, P.; Luís, L.; Barroso, S.; Sarmento, B.; Santos, L.L.. "New trends in guided nanotherapies for digestive cancers: A systematic review". Journal of Controlled Release 209 (2015): 288-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929376547&partnerID=MN8TOARS.
    10.1016/j.jconrel.2015.05.003
  34. Costa C; Pereira S; Lima L; Peixoto A; Fernandes E; Neves D; Neves M; et al. "Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics.". (2015): http://europepmc.org/abstract/med/26569621.
    10.1371/journal.pone.0141253
  35. Santos, J.; Fernandes, E.; Ferreira, J.A.; Lima, L.; Tavares, A.; Peixoto, A.; Parreira, B.; et al. "P53 and Cancer-Associated Sialylated Glycans Are Surrogate Markers of Cancerization of the Bladder Associated with Schistosoma haematobium Infection". PLoS Neglected Tropical Diseases 8 12 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923089418&partnerID=MN8TOARS.
    10.1371/journal.pntd.0003329
  36. Santos, M.; Carvalho, S.; Lima, L.; Nogueira, A.; Assis, J.; Mota-Pereira, J.; Pimentel, P.; et al. "Common genetic polymorphisms in the ABCB1 gene are associated with risk of major depressive disorder in male portuguese individuals". Genetic Testing and Molecular Biomarkers 18 1 (2014): 12-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891864712&partnerID=MN8TOARS.
    10.1089/gtmb.2013.0197
  37. Lima, L.; Oliveira, D.; Tavares, A.; Amaro, T.; Cruz, R.; Oliveira, M.J.; Ferreira, J.A.; Santos, L.. "The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladder tumors is associated with BCG immunotherapy failure". Urologic Oncology: Seminars and Original Investigations 32 4 (2014): 449-457. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899473274&partnerID=MN8TOARS.
    10.1016/j.urolonc.2013.10.012
  38. Lima, L.; Ferreira, J.A.; Tavares, A.; Oliveira, D.; Morais, A.; Videira, P.A.; Medeiros, R.; Santos, L.. "FASL polymorphism is associated with response to bacillus Calmette-Guérin immunotherapy in bladder cancer". Urologic Oncology: Seminars and Original Investigations 32 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84890794225&partnerID=MN8TOARS.
    10.1016/j.urolonc.2013.05.009
  39. Lima, L.; Severino, P.F.; Silva, M.; Miranda, A.; Tavares, A.; Pereira, S.; Fernandes, E.; et al. "Response of high-risk of recurrence/progression bladder tumours expressing sialyl-Tn and sialyl-6-T to BCG immunotherapy". British Journal of Cancer 109 8 (2013): 2106-2114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885909350&partnerID=MN8TOARS.
    10.1038/bjc.2013.571
  40. Vinagre, J.; Almeida, A.; Pópulo, H.; Batista, R.; Lyra, J.; Pinto, V.; Coelho, R.; et al. "Frequency of TERT promoter mutations in human cancers". Nature Communications 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884524540&partnerID=MN8TOARS.
    10.1038/ncomms3185
  41. Ferreira, J.A.; Videira, P.A.; Lima, L.; Pereira, S.; Silva, M.; Carrascal, M.; Severino, P.F.; et al. "Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours". Molecular Oncology 7 3 (2013): 719-731. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878107131&partnerID=MN8TOARS.
    10.1016/j.molonc.2013.03.001
  42. Lima, L.; Dinis-Ribeiro, M.; Longatto-Filho, A.; Santos, L.. "Predictive biomarkers of bacillus Calmette-Guérin immunotherapy response in bladder cancer: Where are we now?". Advances in Urology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866253149&partnerID=MN8TOARS.
    10.1155/2012/232609
  43. Lima, L.; Silva, J.; Amaro, T.; Morais, A.; Lopes, C.; Medeiros, R.; Videira, P.A.; Santos, L.. "IL-4 and TNF-a polymorphisms are associated with risk of multiple superficial tumors or carcinoma in situ development". Urologia Internationalis 87 4 (2011): 457-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84355162794&partnerID=MN8TOARS.
    10.1159/000331882
  44. Palmeira, C.; Lameiras, C.; Amaro, T.; Lima, L.; Koch, A.; Lopes, C.; Oliveira, P.A.; Santos, L.. "CIS is a surrogate marker of genetic instability and field carcinogenesis in the urothelial mucosa". Urologic Oncology: Seminars and Original Investigations 29 2 (2011): 205-211. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952042552&partnerID=MN8TOARS.
    10.1016/j.urolonc.2009.07.022
  45. Lima, L.; Morais, A.; Lobo, F.; Calais-da-Silva, F.M.; Calais-da-Silva, F.E.; Medeiros, R.. "Association between FAS polymorphism and prostate cancer development". Prostate Cancer and Prostatic Diseases 11 1 (2008): 94-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-39149123190&partnerID=MN8TOARS.
    10.1038/sj.pcan.4501002
Preprint
  1. Peixoto, Andreia; Ferreira, Dylan; Miranda, Andreia; Relvas-Santos, Marta; Freitas, Rui; Veth, Tim S.; Brandão, Andreia; et al. "Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells". 2023. http://dx.doi.org/10.1101/2023.10.21.561355.
    10.1101/2023.10.21.561355

Intellectual property

Patent
  1. P A Videira ; Carlos Novo; Liliana Raquel Rodrigues Loureiro; Mylene Adelaide do Rosário Carrascal; Jose Alexandre Ferreira; Angelina de Sá Palma; Lúcio Lara Santos; Lima, Luís. 2021. "L2A5 ANTIBODY OR FUNCTIONAL FRAGMENT THEREOF AGAINST TUMOUR ANTIGENS". Portugal.
  2. Lima, Luís. 2018. "Antibody, functional fragment or probe thereof against tumour antigens".
    Granted/Issued
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05 MicroRNA Profiles and their Clinical Value for Precancerous and Cancerous Colorectal Lesions Identification: A Preliminary Study 30th Porto Cancer Meeting
(Porto, Portugal)
2023/11/09 Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion. 1st Young Researchers’ Day
(Porto, Portugal)
2023/10/25 Building a sample-to-answer CTC technology: joint path of clinical translation. P.CCC Raquel Seruca Immuno-Oncology Club
(Porto, Portugal)
2023/07 Enhanced specificity of CTC identification using a double exclusion biomarker assay.
VI Annual Meeting CINBIO (Vigo, Spain)
2023/06/02 Exploring Circulating Tumor Cells: Advancements in Identification and their Implications for Oral Cancer. II International Congress of UNIPRO Research Unit and II Conference in Advances in Research on Oral Cancer
(Penafiel, Portugal)
2023/05/12 Hypoxia and glucose deprivation induce bladder cancer cells dormancy and immature glycosylation driving cancer aggressiveness. 29th Porto Cancer Meeting
(Porto, Portugal)
2022/09/24 Optimização de imunocitoquímica on-chip para caracterização de Células Tumorais Circulantes em cancro de mama, colorrectal e pulmão 4º Encontro Nacional de Jovens Investigadores em Oncologia
(Porto, Portugal)
2022/02 Label-free Microfluidic-based Isolation of Circulating Tumor Cells from Gastrointestinal Cancer Samples PortASAP Final Meeting
(Tallin, Estonia)
2021 Microfluidic-based Isolation of Gastrointestinal Circulating Tumour Cells EuroNanoForum Conference
(Portugal)
2016 Imunoterapia em Urologia Oncologica: Estado da arte XXI Workshop de Urologia Oncológica
(Carvoeiro, Portugal)
2015 A step towards personalized medicine: establishment of a pharmacogenomics profile of response to BCG intravesical immunotherapy in bladder cancer II INTERNATIONAL HEALTH CONGRESS GAIA-PORTO (II CISGP)
(Porto)
2015 Role of pharmacogenomics in predicting antidepressant response and individualizing therapy II INTERNATIONAL HEALTH CONGRESS GAIA-PORTO
(Gaia, Portugal)
2013 A link between humoral response and the CA19-9 test in gastroesophageal cancer Encontros de Primavera de Oncologia
(Évora, Portugal)
2011 O-Glicomic Signatures of Urinary Glycoporteins in Bladder Cancer Glupor 9 - 9th International Meeting of the Portuguese Carbohydrate Chemistry Group/ 5th Iberian Carbohydrate Meeting
(Vila Real, Portugal)
2010 Carcinoma Urotelial e Superficial da Bexiga, de Alto Risco (CUB): BCG de Manutenção Associa-se a Menor Taxa de Recidiva XIII Jornadas de Oncologia Médica
(Porto)
2008 "Apoptosis and Fas/FasL Pathway: Role of FASL Functional Polymorphism in Prostate Cancer Development ISCO
2008 Apoptosis and Fas/FasL Pathway: Role of FASL Functional Polymorphism in Prostate Cancer Development ISCO
(Amestradam, Netherlands)
2008 Cyclin D1 and bladder cancer:CCND1 polymorphism in bladder carcinogenesis and BCG immunotherapy ESMO
(Estocolmo, Sweden)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current An Integrative Approach for Biomarker Discovery in Colorectal Cancer: From Screening to Therapeutics
Supervisor of Daniela Santos
 Patologia e Genética Molecular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023 - Current Challenging invasive fungal infections: Development of innovative electrochemical nanogenosensors to detect Aspergillus spp, Candida spp, and Zygomycetes
Co-supervisor of Michelle Castanheira
Universidade do Porto, Portugal
2022/01/01 - Current Introducing molecular analysis of Circulating Tumour Cells in the clinic: Their significance in clonal evolution and immune escape in gastrointestinal cancers
Supervisor of Adriana Carneiro
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/10/01 - Current Novel faecal biomarkers for early detection of precancerous lesions and Cancer: Improving the current model for colorectal cancer screening
Supervisor of Beatriz Oliveira
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2025/01 - 2028/12 Unveiling Transcriptome Landscape to Enhance Colorectal Cancer Screening: An Integrated Approach
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/09 - 2025/11 Identification and validation of biomarkers for improvement the colorectal cancer screening
Supervisor
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2024/04 - 2024/07 Blood Biomarkers as a promising approach for Early Colorectal Cancer Screening
Supervisor
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023 - 2024 Enhancing Colorectal Cancer Screening: Identifying Promising Biomarkers for Early Detection
Supervisor of Débora Pinto
 Health Biochemistry (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022 - 2023/11/23 Identification of Fecal Biomarkers for Early Detection of Pre- and Cancerous Colorectal Lesions
Supervisor of Daniela Santos
 Pharmacy-Technology and Medicines and Health Products (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023 - 2023 Assessment of Sialyl-Tn in Stool as a non-invasive Colorectal Cancer Biomarker
Supervisor of João Almeida
 Biotecnologia Medicinal (Degree)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2017/09 - 2021/09 Exploring cancer circulating tumor cells for improved esophageal cancer management and ex vivo models for individualized testing of treatment susceptibility
Co-supervisor of Sofia Cotton
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/09 - 2020/11/24 Circulating Tumour Cells: Paving The Way Towards The Identification of Ephitelial and Mesenchymal Phenotypes in the Clinic
Supervisor of Adriana Carneiro
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09 - 2019/09 Improvement of metastatic gastric cancer management glyco-exploring circulating tumor cells
Supervisor of Dylan Ferreira
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2016/09 - 2017/09 CD44-glycoprofilling: Establishing the molecular basis for target therapeutics in bladder cancer
Co-supervisor of Eliana Janine Soares
 Bioquímica (Master)
Universidade de Aveiro, Portugal
2015/09 - 2016/11 Glycoproteomics Characterization of Advanced Bladder Cancer Toward Novel Therapies
Supervisor of Sofia Cotton
 Biologia Molecular e Celular (Master)
Universidade de Aveiro, Portugal
2013/09 - 2014/09 Glyco-profiling of bladder cancer stem cells based on the chemotherapy sorting approach
Co-supervisor of Beatriz Parreira
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/05 - 2013/09 Macrophages biomarkers in the BCG treatment response in Bladder Cancer
Co-supervisor of Daniela Oliveira
 Bioquímica em Saúde (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06/28 - Current RUBYnanomed: Sessão Pública de Apresentação de Resultados do Projeto Bright (2023) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2016 - Current First Precision Oncology Pre-conference workshop on molecular methods in oncology (2016)
Conference
 Universidade Fernando Pessoa, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11 The role of extracellular vesicles-derived microRNAs in the development of Renal Cell Carcinoma
(Thesis) Arguer
 Patrícia Venâncio (Master)
Instituto Politécnico do Porto, Portugal
2023/09 Research of Biomarkers for the Detection of Colorectal Cancer by Non-Invasive Methods
(Thesis) Arguer
 Maria João Combo (Master)
Universidade de Coimbra, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024 - Current Evaluator for the PATHFINDER CHALLENGE 2023: remoter evaluater, cross reader and evaluation panel member
2015 - Current Evaluator for the MATWIN programme: Maturation & accelerating translation of research projects in oncology with potential for industry

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current Guest Editor of International Journal of Molecular Sciences
2021 - 2022 Guest Editor of International Journal of Molecular Sciences