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Identification

Personal identification

Full name
Rafael Alexandre Carvalho Luís

Author identifiers

Ciência ID
8E1C-2069-D56C
ORCID iD
0000-0002-8305-1625
Projects

Contract

Designation Funders
2025/01/01 - Current iNOVA4Health - Programme in Translational Medicine (UID/04462)
UID/04462
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2025/09/01 - 2028/08/31 DISARM - DISARMing the silent threat of ovarian cancer
GAP-101214318
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 European Commission
Ongoing
2025/09/01 - 2028/08/31 HOPE4Kids - Holistic Oncological Palliative care 4 Europe's Kids
GAP-101233078
Project manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 European Commission
Ongoing
2025/09/01 - 2028/08/31 PCM - Personalized Cancer Medicine
GAP-101233450
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 European Commission
Ongoing
2025/08/01 - 2028/07/31 CHILDCARE - Early Risk Detection in Children with Genetic Predisposition to leukemia
HR25-00537
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona 'la Caixa'
Ongoing
2023/05/01 - 2028/04/30 IntReALL 2020 - International Study for Treatment of Childhood Relapsed ALL 2020
GA-101104582
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 European Commission
Ongoing
2025/05 - 2028/04 eCAN+ - Enhancing the digital capabilities of cancer centres in the European Union to improve prevention and care
GAP-101219434
 European Commission
2025/09/01 - 2027/08/31 CancerWatch - Improving Quality and Timeliness of Cancer Registry Data feeding into the European Cancer Information System
GAP-101219450
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 European Commission
Ongoing
2025/01/01 - 2026/05/31 HyCare - Hybrid Clinical Decision Support System Integrating Rule-based and Machine Learning Approaches
2024.07361.IACDC/2024
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2025/02/11 - 2025/12/31 LS4FUTURE - Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
10.54499/LA/P/0087/2020
Project Manager
Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

iNOVA4Health, Portugal

GREEN-IT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2025/07/03 - 2025/10/30 CuReMa - Plano de Melhoria de Cuidados e Referenciação em Cancro da Mama em São Tomé e Príncipe
034P
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Secretaria-Geral do Ministério da Saúde
Ongoing
2024/11/01 - 2025/10/30 SARC-RON-AI - Integração de Dados Clínicos de Sarcoma com Automação Baseada em IA para o Registo Nacional de Oncologia
2024.07252.IACDC
Project Manager
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Palmer, C.B.; D'Uonnolo, G.; Luís, R.; Meyrath, M.; Uchanski, T.; Chevigné, A.; Szpakowska, M.. "Nanoluciferase-based complementation assay for systematic profiling of GPCR–GRK interactions". 309-321. 2022.
    10.1016/bs.mcb.2022.04.001
  2. Luís, R.; D'Uonnolo, G.; Palmer, C.B.; Meyrath, M.; Uchanski, T.; Wantz, M.; Rogister, B.; et al. "Nanoluciferase-based methods to monitor activation, modulation and trafficking of atypical chemokine receptors". 2022.
    10.1016/bs.mcb.2022.03.002
  3. Luís, Rafael; Brito, Cheila; Pojo, Marta. "Melanoma Metabolism: Cell Survival and Resistance to Therapy". In Advances in Experimental Medicine and Biology, edited by Serpa, Jacinta, 203-223. Springer International Publishing, 2020.
    10.1007/978-3-030-34025-4_11
Conference poster
  1. Luís, Rafael. "The effect of somatropin therapy in residual paediatric CNS tumours in children who developed growth hormone deficiency". Paper presented in 1º Encontro Nacional de Jovens Investigadores em Oncologia, 2019.
Journal article
  1. Luís, Rafael; Volkman, Brian F; Szpakowska, Martyna; Chevigné, Andy. "Extended repertoire of CXC chemokines acting as agonists and antagonists of the human and murine atypical chemokine receptor ACKR2". Journal of Leukocyte Biology 117 4 (2025): https://doi.org/10.1093/jleuko/qiaf013.
    10.1093/jleuko/qiaf013
  2. Szpakowska, M.; D’Uonnolo, G.; Luís, R.; Alonso Bartolomé, A.; Thelen, M.; Legler, D.F.; Chevigné, A.. "New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance". Frontiers in Immunology 14 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85158047113&partnerID=MN8TOARS.
    10.3389/fimmu.2023.1133394
  3. Gray, A.L.; Karlsson, R.; Roberts, A.R.E.; Ridley, A.J.L.; Pun, N.; Khan, B.; Lawless, C.; et al. "Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors". Cell Reports 42 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85145993662&partnerID=MN8TOARS.
    10.1016/j.celrep.2022.111930
  4. Temporão, A.; Sanches-Vaz, M.; Luís, R.; Nunes-Cabaço, H.; Smith, T.K.; Prudêncio, M.; Figueiredo, L.M.. "Excreted trypanosoma brucei proteins inhibit plasmodium hepatic infection". PLoS Neglected Tropical Diseases 15 10 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118950424&partnerID=MN8TOARS.
    10.1371/journal.pntd.0009912
  5. Luís, Rafael; Campos, Catarina; Fragoso, Sofia; Pinto, Felipe; Brito, Cheila; Esteves, Susana; Pataco, Margarida; et al. "High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma". Genes 11 4 (2020): 403. http://dx.doi.org/10.3390/genes11040403.
    10.3390/genes11040403
  6. Margarida Sanches-Vaz; Adriana Temporão; Rafael Luis; Helena Nunes-Cabaço; António M. Mendes; Sarah Goellner; Tânia Carvalho; Luisa M. Figueiredo; Miguel Prudêncio. "Trypanosoma brucei infection protects mice against malaria". PLOS Pathogens 15 11 (2019): e1008145-e1008145. https://doi.org/10.1371/journal.ppat.1008145.
    10.1371/journal.ppat.1008145
Thesis / Dissertation
  1. Luís, Rafael. "Plasmodium berghei liver infection inhibition by host immune response to Trypanosoma brucei". Master, Instituto de Medicina Molecular, 2018. https://repositorio.ul.pt/handle/10451/35241.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019 “How can a parasite help us fight malaria?” VII Jornadas de Investigação em Biologia
Faculdade de Ciências da Universidade de Lisboa (Lisboa, Portugal)
2017 “Plasmodium berghei liver infection inhibition by host immune response to Trypanosoma brucei” iMed Conference 9.0 – AstraZeneca Innovate Competition
Faculdade de Ciências Médicas da Universidade Nova de Lisboa (Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/06 - 2019/11 Targeted inhibition of PIK3CA mutations in glioblastoma cell models
Co-supervisor

Committee member

Activity description
Role 		Institution / Organization
2014 - 2015 Responsável pela divulgação do curso de Biologia da FCUL a estudantes do ensino secundário no evento "Futurália".
Member
 Universidade de Lisboa Faculdade de Ciências, Portugal
Distinctions

Award

2017 Best Oral Communication in Basic Research
AstraZeneca Produtos Farmacêuticos Lda, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal