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Since 2011, I am graduated in Chemistry by Faculty of Sciences of University of Porto and obtained my master degree in Viticulture and Enology in 2016 in FCUP and ISA, from Lisbon. Currently, I'm a PhD student in Sustainable Chemistry and my field research focused on " Nature-inspired synthesis of novel amino-based flavyliums and pyranoflavyliums dyes with the respectives thermodynamic, kinetic, and photochemical studies towards different applications." In December 2023, I attended the Advanced analysis techniques course which provides training in the techniques of liquid chromatography, gas chromatography, mass spectrometry, atomic and molecular spectroscopy. In the last years I have participated in some research projects conducted by Food Polyphenol Lab at Faculty of Sciences of University of Porto. The last project was "Wine-INspired synthesis of blue pyranoflavyliums for topical Photodynamic Therapy". I'm author of 7 papers and co-author of 21 papers in international scientific journals; and I have given five oral presentations at national and international congresses. I am also the holder of patent WO2022172170 - "PROCESS FOR EXTRACTION AND HEMI-SYNTHESIS OF PYRANOANTHOCYANINS AND SKINCARE COSMETIC FORMULATIONS CONTAINING THEM". Portugal. Over the last years, I have also participated in winemaking processes during vintage season at large wine companies (Gran Cruz and The Fladgate Partnership) that has contributed to improve my knowledge about this subject; and in addition, in January 2018, I performed an advanced course of solid and exhausting knowledge of the world of wines, with international recognition (WSET level 3).
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Identification

Personal identification

Full name
Paula Alexandra Carneiro Araújo

Citation names

  • Araújo, Paula

Author identifiers

Ciência ID
7D1F-EA52-7174
ORCID iD
0000-0002-7597-3152

Email addresses

  • paula.araujo@fc.up.pt (Professional)
  • up200700800@edu.fc.up.pt (Professional)
  • paulinha.a.c.araujo@gmail.com (Personal)

Addresses

  • Rua D. Sancho I, nº 1237, 4760-556, Fradelos, Vila Nova de Famalicão, Portugal (Personal)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2019/09/15 - 2034/06/30
Ongoing
 Química Sustentável (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"Nature-inspired synthesis of novel amino-based flavyliums and pyranoflavyliums dyes. Thermodynamic, kinetic, and photochemical studies towards different applications. " (THESIS/DISSERTATION)
2013/04/15 - 2015/12/16
Concluded
 Viticultura e Enologia (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto Superior de Agronomia, Portugal
"Study of the Influence of the Wood Tosting Degree on the phenolic composition of a red wine from the Touriga Nacional variety from the Douro Demarcated Region." (THESIS/DISSERTATION)
 17
2007/09/01 - 2011/09/30
Concluded
 Química (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Study of anthocyanin pigments and derivatives: Isolation, synthesis and characterization of antioxidant properties" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2015/06/01 - 2024/06/30 Researcher (Research) REQUIMTE LAQV Porto, Portugal
Projects

Grant

Designation Funders
2019/06/01 - 2019/11/30 “WINPUT – Wine-inspired synthesis of blue pyranoflavyliums for topical Photodynamic Therapy”
PTDC/QUI-OUT/29013/2017
Research Fellow
REQUIMTE LAQV Porto, Portugal
Ongoing
2016/06/01 - 2019/05/31 VINE&WINE RESIDUES: Unlimited resources of high-value polyphenols for application into Functional Foods.
PTDC/AGR-TEC/2789/2014
Research Fellow
REQUIMTE LAQV Porto, Portugal
Ongoing
2016/02/01 - 2016/05/31 Isolamento, transformação química e caraterização estrutural de compostos fenólicos
QUI/50006
Research Fellow
REQUIMTE LAQV Porto, Portugal
Concluded
2012/09/01 - 2014/10/31 BIOPAD – Bio-inspired synthesis of new classes of anthocyanin derivatives from wines
PTDC/QUI-QUI/117996/2010
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Araújo, Paula; Johan Mendoza; Pina, Fernando; Pereira, Ana Rita; Fernandes, Iva; de Freitas, Victor; Oliveira, Joana. "Kinetic and Thermodynamic characterization of 5-Hydroxy-4´-Dimethylamino-flavylium in the presence of SDS micelles". Paper presented in XXX International Conference on Polyphenols, 2021.
  2. Araújo, Paula. "Synthesis, structural and physical-chemical characterization of blue pyranoflavyliums-4-(dimethylamino)-cinnamyl dyes". Paper presented in International Symposium on Dyes and Pigments, 2019.
  3. Araújo, Paula. "Stabilization of bluish pyranoanthocyanin pigments in aqueous systems using lignin nanoparticles". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, 2019.
  4. Araújo, Paula. "Synthesis, structural and physical-chemical characterization of blue pyranoflavyliums-4-(dimethylamino)-cinnamyl dyes". Paper presented in XXVI Encontro Nacional da Sociedade Potuguesa de Química, 2019.
  5. Jyoti, Divya; Mohan, Devendra. "To probe the equivalence and opulence of nanocrystal and nanotube based dye-sensitized solar cells". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, 2019.
    10.1063/1.4946126
  6. Borges, Alexandra; Araújo, Paula; Basílio, Nuno; Fernandes, Ana; Mateus, Nuno; Pina, Fernando; de Freitas, Victor; Oliveira, Joana. "Sinergia - competição entre os flava-3-ois e derivados da lenhina para a estabilização da cor vermelha das antocianinas". Paper presented in XXIV Encontro Luso Galego de Química, 2018.
  7. Araújo, Paula. "Lignin nanoparticles loaded with bluish pyranoanthocyanins pigments. Increased stability in aqueous systems". Paper presented in XIV Encontro de Química dos Alimentos, 2018.
  8. Araújo, Paula; Figueiredo. M. C. ; Fernandes, Ana; Mateus, Nuno; de Freitas, Victor; Oliveira, Joana. "Interaction of malvidin-3-O-glucoside and its derivatives with other wine and grapes components and their impact on the color". Paper presented in In Vino Analytica Scientia, 2017.
  9. Araújo, Paula; Fernandes, Ana; de Freitas, Victor; Oliveira, Joana. "A new chemical pathway yielding A-type vitisins in red wines". Paper presented in In Vino Analytica Scientia, 2017.
  10. Araújo, Paula. "Impact of a pectic cell wall polysaccharide on oenin copigmentation mechanism". Paper presented in In Vino Analytica Scientia, 2017.
  11. Oliveira, Joana; Araújo, Paula; Fernandes, Ana; Mateus, Nuno; de Freitas, Victor. "Influence of structural features of amino-based pyranoanthocyanins on their acid-base equilibria in aqueous solution". Paper presented in XXII Encontro Luso Galego de Química, 2016.
  12. Araújo, Paula; Fernandes, Ana; Mateus, Nuno; de Freitas, Victor; Oliveira, Joana. "Optimization of anthocyanins extration procedures from grape pomace from differnt varieties of the Douro Region using "green methodologies". Paper presented in XIII Encontro Química dos Alimentos, 2016.
  13. Fernandes, Ana; Brás NF; Brás, Joana ; Oliveira, Joana; Araújo, Paula; Mateus, Nuno; de Freitas, Victor. "Impact of a cell wall polysaccharide on anthocyanins copigmentation mechanism". Paper presented in XIII Encontro de Química dos Alimentos, 2016.
  14. Sousa, Andre; Araújo, Paula; Mateus, Nuno; de Freitas, Victor. "Deoxyvitisins: a new set of pyrano-3-deoxyanthocyanidins". Paper presented in 10º Encontro Nacional de Química Orgânica, 2013.
  15. Sousa, Andre; Araújo, Paula. "Deoxyvitisins: a new set of pyrano-3-deoxyanthocyanidins". Paper presented in 7th International Workshop on Anthocyanins, 2013.
Journal article
  1. Correia, Patrícia; Araújo, Paula; Plácido, Alexandra; Pereira, Ana Rita; Bessa, Lucinda J.; Mateus, Nuno; de Freitas, Victor; Oliveira, Joana; Fernandes, Iva. "Light-activated amino-substituted dyes as dual-action antibacterial agents: bio-efficacy and AFM evaluation ¿". Dyes and Pigments (2024):
    Accepted
  2. Araújo, Paula; Oliveira, Joana; Basílio, Nuno; Parola, A. Jorge; de Freitas, Victor; Pina, Fernando. "Modulating the thermodynamics, kinetics and photochemistry of 7-diethylamino-4'-dimethylaminoflavylium in water/ethanol, SDS and CTAB micelles". Physical Chemistry Chemical Physics 24 29 (2022): 17593-17604. http://dx.doi.org/10.1039/d2cp01966c.
    Published • 10.1039/d2cp01966c
  3. Oliveira, Hélder; Araújo, Paula; Pereira, Ana Rita; Mateus, Nuno; de Freitas, Victor; Oliveira, Joana; Fernandes, Iva. "Photoactivated cell-killing amino-based flavylium compounds". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-01485-y.
    Published • 10.1038/s41598-021-01485-y
  4. Araújo, Paula; Rita Pereira, Ana; de Freitas, Victor; Mateus, Nuno; Fernandes, Iva; Oliveira, Joana. "Synthesis, structural characterization and chromatic features of new 2-phenyl-1-benzopyrylium and 2-phenyl-styryl-1-benzopyrylium amino-based blue dyes". Tetrahedron Letters 85 (2021): 153487. http://dx.doi.org/10.1016/j.tetlet.2021.153487.
    Published • 10.1016/j.tetlet.2021.153487
  5. Coelho, Patrícia; Oliveira, Joana; Fernandes, Iva; Araújo, Paula; Pereira, Ana Rita; Gameiro, Paula; Bessa, Lucinda J.. "Pyranoanthocyanins Interfering with the Quorum Sensing of Pseudomonas aeruginosa and Staphylococcus aureus". International Journal of Molecular Sciences 22 16 (2021): 8559. http://dx.doi.org/10.3390/ijms22168559.
    Published • 10.3390/ijms22168559
  6. Correia, Patrícia; Araújo, Paula; Ribeiro, Carolina; Oliveira, Hélder; Pereira, Ana Rita; Mateus, Nuno; de Freitas, Victor; et al. "Anthocyanin-Related Pigments: Natural Allies for Skin Health Maintenance and Protection". Antioxidants 10 7 (2021): 1038. http://dx.doi.org/10.3390/antiox10071038.
    Published • 10.3390/antiox10071038
  7. Araújo, Paula; Mendoza, Johan; Pina, Fernando; Pereira, Ana Rita; Fernandes, Iva; de Freitas, Victor; Oliveira, Joana. "Photochemistry of 5-Hydroxy-4'-Dimethylaminoflavylium in the presence of SDS micelles. The role of metastable states of flavylium cation-quinoidal base and trans-chalcones". Journal of Photochemistry and Photobiology A: Chemistry 402 (2020): 112827. http://dx.doi.org/10.1016/j.jphotochem.2020.112827.
    Published • 10.1016/j.jphotochem.2020.112827
  8. Oliveira, Hélder; Correia, Patrícia; Pereira, Ana Rita; Araújo, Paula; Mateus, Nuno; de Freitas, Victor; Oliveira, Joana; Fernandes, Iva. "Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems". International Journal of Molecular Sciences 21 20 (2020): 7464. http://dx.doi.org/10.3390/ijms21207464.
    Accepted • 10.3390/ijms21207464
  9. Mendoza, Johan (671D-D8A2-805D; Oliveira, Joana; Araújo, Paula; Basílio, Nuno; Teixeira, Natércia; Brás, Natércia F.; Pina, Fernando; Yoshida, Kumi; de Freitas, Victor. "The peculiarity of malvidin 3-O-(6-O-p-coumaroyl) glucoside aggregation. Intra and intermolecular interactions". Dyes and Pigments 180 (2020): 108382. http://dx.doi.org/10.1016/j.dyepig.2020.108382.
    Published • 10.1016/j.dyepig.2020.108382
  10. Pinto, Ana Lucia; Cruz, Hugo; Oliveira, Joana; Araújo, Paula; Cruz, Luis; Gomes, Vânia; Silva, Cassio P.; et al. "Dye-sensitized solar cells based on dimethylamino-p-bridge-pyranoanthocyanin dyes". Solar Energy 206 (2020): 188-199. http://dx.doi.org/10.1016/j.solener.2020.05.101.
    Published • 10.1016/j.solener.2020.05.101
  11. Barbosa, Pedro; Araújo, Paula; Oliveira, Joana; Fraga, Irene; Pissarra, João; Amaral, Carla. "Metabolic pathways of degradation of malvidin-3-O-monoglucoside by Candida oleophila". International Biodeterioration & Biodegradation 144 (2019): 104768. http://dx.doi.org/10.1016/j.ibiod.2019.104768.
    Accepted • 10.1016/j.ibiod.2019.104768
  12. Pinto, Ana Lucia; Oliveira, Joana; Araújo, Paula; Calogero, Giuseppe; de Freitas, Victor; Pina, Fernando; Parola, A. Jorge; Lima, J. Carlos. "Study of the multi-equilibria of red wine colorants pyranoanthocyanins and evaluation of their potential in dye-sensitized solar cells". Solar Energy 191 (2019): 100-108. http://dx.doi.org/10.1016/j.solener.2019.08.050.
    Accepted • 10.1016/j.solener.2019.08.050
  13. Araújo, Paula. "Stabilization of bluish pyranoanthocyanin pigments in aqueous systems using lignin nanoparticles.". Dyes and Pigments (2019):
    Under revision
  14. Araújo, Paula; Basílio, Nuno; Fernandes, Ana; Mateus, Nuno; de Freitas, Victor; Pina, Fernando; Oliveira, Joana. "Impact of Lignosulfonates on the Thermodynamic and Kinetic Parameters of Malvidin-3-O-glucoside in Aqueous Solutions". Journal of Agricultural and Food Chemistry 66 25 (2018): 6382-6387. http://dx.doi.org/10.1021/acs.jafc.8b02273.
    Published • 10.1021/acs.jafc.8b02273
  15. Araújo, Paula; Basílio, Nuno; Azevedo, Joana; Fernandes, Ana; Mateus, Nuno; Pina, Fernando; de Freitas, Victor; Oliveira, Joana. "Colour modulation of blue anthocyanin-derivatives. Lignosulfonates as a tool to improve the water solubility of natural blue dyes". Dyes and Pigments 153 (2018): 150-159. http://dx.doi.org/10.1016/j.dyepig.2018.02.019.
    Published • 10.1016/j.dyepig.2018.02.019
  16. Araújo, Paula. "Malvidin 3-Glucoside-Fatty Acid Conjugates: From Hydrophilic toward Novel Lipophilic Derivatives". Journal of Agricultural and Food Chemistry 65 31 (2017): 6513-6518.
    Published • 10.1021/acs.jafc.6b05461
  17. Araújo, Paula. "High-pressure assisted extraction of bioactive compounds from industrial fermented fig by-product". Journal of Food Science and Technology 54 8 (2017): 2519-2531.
    Published • 10.1007/s13197-017-2697-2
  18. Calisto, Rita; Graça, Ana Patrícia; Lopes, Ana Rita; Araújo, Paula; Pinto, Eugénia; Oliveira, Joana; Catita, José A.M.; et al. "Linking microbial community on grapes from two Portuguese wine regions to the biogenic amines production in musts". BIO Web of Conferences 9 (2017): 02015. http://dx.doi.org/10.1051/bioconf/20170902015.
    Open access • Published • 10.1051/bioconf/20170902015
  19. Araújo, Paula. "Experimental Design, Modeling, and Optimization of High-Pressure-Assisted Extraction of Bioactive Compounds from Pomegranate Peel". Food and Bioprocess Technology 10 5 (2017): 886-900.
    Published • 10.1007/s11947-017-1867-6
  20. Oliveira, Joana; Araújo, Paula; Fernandes, Ana; Mateus, Nuno; de Freitas, Victor. "A new chemical pathway yielding A-type vitisins in red wines". International Journal of Molecular Sciences 18 4 (2017):
    Published • 10.3390/ijms18040762
  21. Oliveira, Joana; Araújo, Paula; Fernandes, Ana; Mateus, Nuno; de Freitas, Victor. "Synthesis and Structural Characterization of Amino-Based Pyranoanthocyanins with Extended Electronic Delocalization". Synlett (2016):
    Published • 10.1055/s-0035-1562471
  22. Sousa, André; Araújo, Paula; Azevedo, Joana; Cruz, Luís; Fernandes, Iva; Mateus, Nuno; de Freitas, Victor. "Antioxidant and antiproliferative properties of 3-deoxyanthocyanidins". Food Chemistry 192 (2016): 142-148.
    Published • http://dx.doi.org/10.1016/j.foodchem.2015.06.108
  23. Sousa, A.; Araújo, P.; Azevedo, J.; Cruz, L.; Fernandes, I.; Mateus, N.; De Freitas, V.. "Antioxidant and antiproliferative properties of 3-deoxyanthocyanidins". Food Chemistry 192 (2016): 142-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936802759&partnerID=MN8TOARS.
    10.1016/j.foodchem.2015.06.108
  24. Cruz L; Fernandes VC; Araújo P; Mateus N; de Freitas V. "Synthesis, characterisation and antioxidant features of procyanidin B4 and malvidin-3-glucoside stearic acid derivatives.". Food Chemistry 174 (2015): 480-486. http://europepmc.org/abstract/med/25529709.
    Published • 10.1016/j.foodchem.2014.11.062
  25. Sousa A; Araújo P; Cruz L; Brás NF; Mateus N; De Freitas V. "Evidence for copigmentation interactions between deoxyanthocyanidin derivatives (oaklins) and common copigments in wine model solutions.". J Agric Food Chem. 62 29 (2014): 6995-7001. http://europepmc.org/abstract/med/24392836.
    Published • 10.1021/jf404640m
  26. Sousa, Andre; Cabrita, Luis; Araujo, Paula; Mateus, Nuno; Pina, Fernando; de Freitas, Victor. "Color stability and spectroscopic properties of deoxyvitisins in aqueous solution". New Journal of Chemistry 38 2 (2014): 539-544. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000330043700012&KeyUID=WOS:000330043700012.
    Published • 10.1039/c3nj01271a
  27. Sousa A; Petrov V; Araújo P; Mateus N; Pina F; de Freitas V. "Thermodynamics, kinetics, and photochromism of oaklins: a recent family of deoxyanthocyanidins.". The Journal of Physical Chemistry B J. Phys. Chem. B 2013, 117, 6, 1901-1910 117 6 (2013): 1901-1910. http://europepmc.org/abstract/med/23320749.
    Published • 10.1021/jp3110216
  28. Sousa, Andre; Araujo, Paula; Mateus, Nuno; de Freitas, Victor. "Deoxyvitisins: a new set of pyrano-3-deoxsranthocyanidins". Tetrahedron Letters 54 35 (2013): 4785-4788. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000323020400046&KeyUID=WOS:000323020400046.
    Published • 10.1016/j.tetlet.2013.06.135
Working paper
  1. Araújo, Paula. 2017. "Influence of the structural features of amino-based pyranoanthocyanins on their acid-base equilibria in aqueous solutions".
    10.1016/j.dyepig.2017.03.005
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/22 The Impressive Colors of the Bis-amino Styryl Flavylium System. Switching from Violet, Green, Orange and Magenta Colors XXVII Encontro Luso Galego de Química
Portuguese Chemical Society (Porto, Portugal)
2022/11/17 Multistate of chemical reactions of 7-diethylamino-4'-dimethylaminoflavylium. Thermodynamics, Kinetics and Photochemistry modulated by water: ethanol, SDS and CTAB Micelles XXVIth Galician/Portuguese International Conference on Chemistry
Portuguese Chemical Society (Galicia, Spain)
2022/08/31 Modulating the Thermodynamics, Kinetics and Photochemistry of 7-Diethylamino-4'-dimethylaminoflavylium in Water/Ethanol, SDS and CTAB Micelles Work presented in 8º EuChemS_Chemistry Congress
European Chemical Society (Lisboa)
2022/04/21 Synthesis and structural characterization of a new pyranoflavylium and brominated pyranoflavylium dyes for application in Photodynamic therapy 14th National Organic Chemistry Meeting (14ENQO) & 7th National Medicinal Chemistry Meeting
Portuguese Chemical Society (Lisboa - Caparica, Portugal)
2018/11/21 Nanopartículas de lenhina para a encapsulação de piranoantocianinas azuis. Estabilidade em sistemas aquosos. XXIV Encontro Luso Galego de Química
Sociedade Portuguesa de Química (PORTO, Portugal)
2018/07/16 Lignin nanoparticles loaded with blue pyranoanthocyanin dimers. Stability in aqueous systems. XXIXth International Conference on Polyphenols 9th Tannin Conference
(Madison, United States)