Personal identification

Full name

Natércia Conceição

Citation names

• Conceição, Natércia

Author identifiers

Ciência ID

7C11-760D-F425

ORCID iD

0000-0002-5057-0912

Email addresses

• nconcei@ualg.pt (Professional)

Addresses

• CCMAR, Universidade do Algarve, Campus de Gambelas, 8000-139, Faro, Faro, Portugal (Professional)

Websites

• https://www.ccmar.ualg.pt/group/comparative-adaptive-and-functional-skeletal-biology (Professional)

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Beginner (A1)	Intermediate (B1)	Intermediate (B1)	Beginner (A1)

	Degree	Classification
2002 Concluded	Biologia Molecular (Doutoramento) Universidade do Algarve, Portugal "Controle da expressão genética da proteína da matriz extracelular matrix Gla protein: estudos comparativos em peixes e anfíbios" (THESIS/DISSERTATION)	Aprovada
1998 Concluded	Biologia Celular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Mutações e Instabilidade Genética no carcinoma colorrectal" (THESIS/DISSERTATION)	Muito Bom
1993 Concluded	Biologia (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Detecção do gene nm23 no cancro da mama" (THESIS/DISSERTATION)	15 valores

Teaching in Higher Education

	Category Host institution	Employer
2024/12/17 - Current	Associate Professor (University Teacher)	Universidade do Algarve, Portugal
2016/10/01 - 2024/12/16	Assistant Professor (University Teacher)	Universidade do Algarve, Portugal
2012 - 2016	Invited Assistant Professor (University Teacher)	Universidade do Algarve, Portugal
2005 - 2006	Invited Assistant Professor (University Teacher)	Universidade do Algarve, Portugal

Others

	Category Host institution	Employer
2015 - 2016	Post graduate Research Biologist, FCT fellowship	Centro de Ciências do Mar, Portugal
2009/01/01 - 2015/09/30	Post graduate Research Biologist, FCT fellowship	Centro de Ciências do Mar, Portugal
2003 - 2009	Post graduate Research Biologist, FCT fellowship	Centro de Ciências do Mar, Portugal
2000/11/02 - 2001/11/01	Invited assistant	Universidade do Algarve - Campus de Gambelas, Portugal

Grant

	Designation	Funders
1997/04 - 1997/10	PTHrP in sea bream development and physiology FAIR-CT96-1742 Research Fellow

Contract

	Designation	Funders
2025/02/01 - Current	Rescuing functional defects in a zebrafish model of CDKL5 deficiency CDKL5-22-103-02 Co-Principal Investigator (Co-PI)	Ongoing
2025/01/01 - 2027/12/31	Inovacel: Sustentabilidade e Inovação na Aquacultura Celular: Uma Abordagem Circular com Microalgas. Inovacel Researcher
2023/03/01 - 2025/03/07	Screening for molecules capable of rescuing CDKL5 deficiency phenotypes using Zebrafish models. 2022.06526.PTDC Co-Principal Investigator (Co-PI)	Ongoing
2020/04/01 - 2024/03/30	Understanding the pathophysiology of Keutel Syndrome: A path towards cure EJPRD/0004/2020 Researcher Centro de Ciências do Mar, Portugal	Concluded
2022/05/01 - 2024/02/29	Rescuing functional defects in a zebrafish model of CDKL5 deficiency: Contribution to the identification of therapeutic targets CDKL5-22-103-01. 2022 Co-Principal Investigator (Co-PI)
2021/01/01 - 2023/06/30	A água de salmoura como fonte sustentável de compostos para o desenvolvimento de produtos comerciais para aquacultura POCI-01-0247-FEDER-047200 Researcher	Concluded
2018/11/01 - 2021/10/31	KCITAR ALGARVE ALG-08-5864-FSE-000004 K.CITAR/10IS00018	Concluded
2019/02 - 2020/12	Zebrafish as model to analyze CDKL5 function MDBR-19-104-CDKL5 Researcher	Concluded
2018/01 - 2020/12	BLUE (marine) biotechnology as a platform for innovation in Atlantic Area towards the smart and sustainable growth of Europe on HUMAN’s health and well-being BLUEHUMAN Researcher	Concluded
2020/05/01 - 2020/07/30	Development of a new assay do detect SARS-CoV-2 directly from clinical sample #126_596760136 Researcher Universidade do Algarve - Campus de Gambelas, Portugal	Concluded
2017/06 - 2020/05	Development and implementation of diets supplemented in seaweeds rich in vitamin K in the cultivation of sole (Solea senegalensis) 16-02-01-FMP-0058 Researcher	Concluded
2017/06 - 2020/05	New marine compounds as nutritional source for improved quality and fish welfare in aquaculture 16-02-01-FMP-0057 Researcher Centro de Ciências do Mar, Portugal	Concluded
2017 - 2020/03	Bases for the implementation of a new species in aquaculture in Portugal 16-02-01-FMP-0055 Researcher	Concluded
2016/04 - 2019/03	Development of a micronutrient premixes to optimize diets for marine fish larvae. 33/SI/2015 Researcher Centro de Ciências do Mar, Portugal	Concluded
2013 - 2015	Translational bigenomics investigation in Leber´s hereditary optic neuropathy: genotype-phenotype correlation PTDC/DTP-EPI/0929/2012 Researcher	Concluded
2009/03 - 2013/02	ASSEMBLE: Association of European Marine Biological Laboratories FP7-227799 Researcher	Concluded
2005 - 2008	Spatial-temporal pattern of expression and regulation of Matrix Gla Protein (MGP) during early development in X. laevis. POCTI/BIA-BCM/58677/2004 Principal investigator	Concluded
2003 - 2006	Effect of extracellular calcium on MGP gene expression POCTI/BCI/48748/2002/FCT Researcher	Concluded
1998 - 2001	Molecular Cloning, Tissue distribution and developmental appearance of Matrix Gla protein in the African frog Xenopus laevis NATO CRG (SA5-2-05/CRG 940751) Researcher	Concluded
1998 - 2000	Characterization of Matrix Gla and Bone Gla proteins gene expression in different developmental stages of the seabream Sparus aurata PRAXIS/ BIA/469/94 Researcher	Concluded
1995 - 1998	Development of mussel-specific expression vectors suitable for transgenic organisms: implications on the establishment of mollusc continuous cell lines. AIR3.CT94.2487 Researcher	Concluded

Other

	Designation	Funders
2023/01/01 - 2027/12/31	INTEC (01TN1123) International Network on Ectopic Calcification 01TN1123 – INTEC Researcher
2015 - 2016	Insights into Matrix Gla protein (MGP) regulation in colorectal cancer SPG2015 Researcher	Concluded
2005/03 - 2008/08	MGE: Marine Genomics Europe Network of Excellence GOCE-CT-2004:505403 Researcher
2006 - 2008	Investigation of runx3 structure and function in zebrafish neural crest B-47/07 CRUP/Treaty of Windsor 2006/2008 Researcher	Concluded
2004 - 2005	The Runx2/Cbfa1 transcription factor: functional analysis using a novel approach in the zebrafish LIS/992/2 CRUP/Treaty of Windsor 2004/2005 Researcher	Concluded

Publications

Conference abstract	T Varela; B Ferreira; A Hernández-Rodríguez; V Pinto; D Varela; Conceição, Natércia; Cancela, ML. "Identification of therapeutic molecules for CDKL5 deficiency disorder using zebrafish-based drug screening". Paper presented in IX Clinical Biochemistry Workshop, 2024. Published M Chaves; B Ferreira; J Galhardas; S Guerreiro; E Houghton-Larsen; T Nehring; E Ninou; et al. "Bioinformatic analysis identifies Oryzias latipes as a valid new model for analysis of MGP gene function.". Paper presented in IX Clinical Biochemistry Workshop, 2024. L Geraldo, L Miguel, N Conceição, J Santos, JK Venkatesan, M Cucchiarini, M Simão, ML Cancela. "rAAV-mediated overexpression of Gla-deficient mutant Matrix Gla Protein limits its potential to inhibit mineralization in SaOS2 cells.". Paper presented in IX Clinical Biochemistry Workshop, 2024. L Miguel, M Simão, N Conceição, ML Cancela. "Histological characterization of zebrafish mgp mutant (MGP_¿18).". Paper presented in IX Clinical Biochemistry Workshop, 2024. Published D Varela, T Varela, N Conceição, ML Cancela. "miR-142a-3p regulates ZNF687 during MC3T3-E1 osteoblast differentiation". Paper presented in IX Clinical Biochemistry Workshop, 2024. Published N Conceição, ML Cancela. "Integrando Bioinformática e Práticas Laboratoriais no Ensino de Genética.". Paper presented in 10.º Congresso Nacional de Práticas Pedagógicas no Ensino Superior (CNaPPES.24), 2024. Published D Varela; T Varela; J Rosa; A Nunes; Conceição, Natércia; ML Cancela. "Zebrafish as a model to assess the effects of thalidomide in limb development.". Paper presented in Bone Reports, 2021. Published Tatiana Varela; Gil Martins; Débora Varela; Conceição, Natércia; M. Leonor Cancela. "The Use of Dominant Negative Strategy in Zebrafish to study CDKL5 Deficiency Disorder". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics, 2020. D Varela; N Conceição; ML Cancela. "Regulation of ZNF687 by the bone-related transcription factors DLX5 and HOXD13 through binding sites overlapping CpG sites". Paper presented in Medicine - Abstract of 24rd Annual Meeting of the Portuguese-Society-of-Human-Genetics., 2020. Published T Varela; G Martins; D Varela; M Vitorino; Conceição, Natércia; ML Cancela. "Zebrafish: an interesting model to study CDKL5 deficiency disorder". Paper presented in Medicine - Abstract of 23rd Annual Meeting of the Portuguese-Society-of-Human-Genetics., 2019. Published D Varela; T Varela; P Azevedo; A Ferreira; A Silva; N Marques; S Pereira; et al. "Functional analysis of two novel TBX5 mutations present in Holt-Oram syndrome patients with different clinical manifestations". Paper presented in Revista portuguesa de cirurgia cardio-torácica e vascular. Abstract of SPCCTV, 2019. Published Caiado, H.; Conceição, Natércia; D Tiago; A Marreiros; AM Vaz; S Vicente; JL Enriquez; et al. "MGP overexpression is associated with a worse prognosis and survival outcome in colorectal adenocarcinomas". Paper presented in 2nd jornadas do Algarve Biomedical Center, 2018. Published D Varela; Conceição, Natércia; A Ferreira; N Marques; AP Silva; Cancela ML. "Functional analysis of a novel TBX5 c.246_249delGATG mutation present in a Holt-Oram syndrome patient". Paper presented in 2nd jornadas do Algarve Biomedical Center, 2018. Published T Varela; Conceição, Natércia; Laizé, Vincent; P caldeira; A Marreiros; H Guerreiro; Cancela, ML. "DUSP4 transcripts expression as a potential biomarker for colorectal cancer". Paper presented in 2nd jornadas do Algarve Biomedical Center, 2018. Published G Sequeira; P carvalho; C Ribeiro; A Alfaia; Conceição, Natércia; ML Cancela. "Characterization of Paget´s Disease of Bone Patients from the South of Portugal (Algarve and Alentejo) – Clinical and Genetic Aspects.". Paper presented in Arthritis Rheumatol, 2018. Published I Silva; L Michou; Cancela, ML; Conceição, Natércia. Corresponding author: Conceição, Natércia. "Functional study of OPTN promoter: new OPTN regulators and effect of genetic variants". Paper presented in European Journal of Clinical Investigation, 2016. Published M Vitorino; Conceição, Natércia; A Adrião; ML Cancela. "Zebrafish as a disease model for studying human Rett Syndrome.". Paper presented in European Journal of Clinical Investigation, 2016. Published IAL Silva; Conceição, Natércia; Cancela, ML. "OPTN and CCDC3 share a bidirectional promoter region that is regulated by NfkB". Paper presented in Bone Abstracts, 2016. Published IAL Silva; Conceição, Natércia; L Michou; ML Cancela. "Comparative analysis of human and zebrafish OPTN: molecular and evolutionary perspectives". Paper presented in Bone Abstracts, 2016. Published VP Roberto; Conceição, Natércia; MJ Nunes; E Rodrigues; Cancela, ML; DM Tiago. "miR-214: a novel regulator of chondrogenesis?". Paper presented in Bone Abstracts, 2016. Published Silva, Iris AL; Conceição, Natércia; Michou, Laëtitia; Cancela, M. Leonor. "Functional analysis of a promoter polymorphism of optineurin, a gene associated to Paget's disease of bone.". Paper presented in European Calcified Tissue Society Meeting 2014, 2014. Published • 10.1530/boneabs.3.PP191 C Fazenda; Conceição, Natércia; ML Cancela. "Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene". Paper presented in The FEBS Journal, 2014. Published I Silva; Conceição, Natércia; L Michou; Cancela, ML. "Functional study of Optineurin (OPTN) variants associated with Paget’s disease of bone". Paper presented in J Bone Miner Res, 2014. Published FAZENDA, CINDY; Conceição, Natércia; Leonor Cancela. "Trancription factors from Sox family regulate zebrafish Gla-rich protein 2 gene". 2014. 10.1111/febs.12919 Silva, Iris AL; Conceição, Natércia; Michou, Laëtitia; Cancela, M. Leonor. "Genetic variation in PDB6 locus and Paget´s Disease of Bone.". Paper presented in V Clinical Biochemistry Workshop, 2013. Published • . I Silva; Conceição, Natércia; L Michou; Cancela, ML. ") Single nucleotide polymorphisms identification and functional analysis in PDB6 locus: a target locus for Paget". Paper presented in . European Calcified Tissue Society Congress, 1 (Publisher: BioScientifica), 2013. Published Conceição, Natércia; B Simões; ML Cancela. "Functional analysis of the two Runx3 promoters in osseous and non-osseous cells: implications for tissue/differentiation speci¿c transcription of distinct isoforms.". Paper presented in Bone Abstracts, 2013. Published I Silva; Conceição, Natércia; L Michou; Cancela, ML. "Single nucleotide polymorphisms identification and functional analysis in PDB6 locus: a target locus for Paget's disease of bone". Paper presented in Bone Abstracts, 2013. Published A Adrião; Conceição, Natércia; Gavaia, PJ; Cancela ML. "Zebrafish as a model to study craniofacial phenotypes related to human MEF2C mutations.". Paper presented in European Journal of Clinical Investigation, 2013. Published Cancela, ML; V Laizé; Conceição, Natércia; DM Tiago; AT Maia; A Bensimon-Brito; PJ Gavaia. "Matrix Gla protein expression: a complex process involving the use of alternative promoters, multiple splicing events and microRNAs". Paper presented in FEBS International Workshop on New Developments in RNA Biology, 2012. Published Conceição, Natércia; C Fazenda; B Simões; Cancela, ML. "Transcriptional regulation of the Xenopus laevis Matrix Gla protein gene". Paper presented in Calcified Tissue International, 2008. Published Conceição, Natércia; B Simões; Fazenda, C.; ML Cancela. "Runx2-mediated regulation of the Matrix Gla Protein gene". Paper presented in The FEBS J., 2007. Published B Simões; A Silva; M Vitorino; Conceição, Natércia; J Belo; Cancela, ML. "Phenotypic observation of Xenopus laevis MGP loss of function.". Paper presented in The FEBS J., 2007. Published Conceição, Natércia; J Belo; ML Cancela. "Alternate promoters and developmental modulation of expression of the Xenopus laevis MGP gene". Paper presented in Experimental Pathology and Health Sciences, 2007. Published Conceição, Natércia; Schüle, R.; Cancela, ML. "Characterization of the 5’flanking region of the Xenopus laevis Matrix Gla protein (MGP) gene". Paper presented in Eur. J. Biochem. The FEBS J., 2001. Published Cancela, ML; DC Simes; P Rodrigues; Conceição, Natércia; JP Reia; MK Williamson; PA Price. "Expression of Matrix Gla protein (MGP) in fish and amphibians: a model system to study the evolution of MGP function". Paper presented in J. Bone Min. Res, 2000. Published Conceição, Natércia; M Ohresser; Schüle, R.; Cancela, ML. "Molecular cloning and regulation of the Xenopus laevis Matrix Gla Protein gene.". Paper presented in J. Bone Min. Res., 1999. Published
Conference poster	T Varela; D Varela; Ana Hernandez; J Santos; Conceição, Natércia; Cancela, ML. "Development of a zebrafish screening methodology for identification of therapeutic candidates for cdkl5 deficiency disorder". Paper presented in V International Meeting of the Portuguese Society of Genetics, 2024. M Simão; G Carmo; L Miguel; Conceição, Natércia; Gavaia, P; Cancela, ML. "Analysis of the impact of mgp_¿10 mutation on zebrafish bone metabolism". Paper presented in V International Meeting of the Portuguese Society of Genetics, 2024. M Vitorino; Conceição, Natércia; D Varela; G Tiscornia; Cancela, ML. "Is MGP essential for ear regeneration in Acomys?". Paper presented in V International Meeting of the Portuguese Society of Genetics, 2024. C Ribeiro; M Simão; Cancela, ML; Conceição, Natércia. "Potential Prognosis and Diagnostic Value of MEF2C in Colorectal Cancer". Paper presented in V International Meeting of the Portuguese Society of Genetics, 2024. Márcio Simão; L Geraldo; C Rodrigues; Conceição, Natércia; Gavaia, P; JK Venkatesan; M Cucchiarini; Cancela, ML. Corresponding author: Cancela, ML. "rAAV-mediated transduction of ATDC5 and Saos-2 cells with mutant Matrix Gla Protein (MGP) transcripts showed the impact of Gla domain and Serine phosphorylation on the inhibition of mineralization". Paper presented in INTEC 2024, 2024. Márcio Simão; C Fazenda; M Vitorino; I-S Yu; GS Diogo; RP Pirraco; J Moreira-Silva; et al. "UCMA loss of function contributed to accelerate growth and bone mineralization and appears to increase susceptibility for osteoarthritis progression in association with age". Paper presented in INTEC 2024, 2024. T Varela; J Santos; A Hernández-Rodríguez; V Pinto; D Varela; Conceição, Natércia; Cancela, ML. "Identification of therapeutic molecules for CDKL5 deficiency disorder using zebrafish-based drug screening". Paper presented in IX Workshop de Bioquímica Clínica, 2024. D Varela; T Varela; Conceição, Natércia; ML Cancela. "miR-142a-3p regulates ZNF687 during MC3T3-E1 osteoblast differentiation". Paper presented in IX Workshop de Bioquímica Clínica, 2024. M Chaves; B Ferreira; J Galhardas; S Guerreiro; E Houghton-Larsen; T Nehring; E Ninou; et al. "Bioinformatic analysis identifies Oryzias latipes as a valid new model for analysis of MGP gene function". Paper presented in IX Workshop de Bioquímica Clínica, 2024. L Geraldo; L Miguel; Conceição, Natércia; J Santos; JK Venkatesan; M Cucchiarini; ML Cancela. "rAAV-mediated overexpression of Gla-deficient mutant Matrix Gla Protein limits its potential to inhibit mineralization in SaOS2 cells". Paper presented in IX Workshop de Bioquímica Clínica, 2024. Larissa Miguel; Simão, Márcio; Conceição, Natércia; Cancela, ML. "Histological characterization of zebrafish mgp mutant (MGP_¿18)". Paper presented in IX Workshop de Bioquímica Clínica, 2024. T Varela; J Santos; A Hernández-Rodríguez; V Pinto; D Varela; Conceição, Natércia; ML Cancela. "Zebrafish-based drug screening identifies candidate molecules for CDKL5 Deficiency Disorder therapeutic applications". Paper presented in CDKL5 Forum, 2023. D Varela; T Varela; Conceição, Natércia; ML Cancela. "Post-transcriptional regulation of znf687 during mc3t3-e1 osteoblast differentiation". Paper presented in IV International Meeting of the Portuguese Society of Genetics, 2023. T Varela; D Varela; Conceição, Natércia; ML Cancela. "Zebrafish mutant as a model for cdkl5 deficiency disorder: insights into neuron-skeletal defects". Paper presented in IV International Meeting of the Portuguese Society of Genetics, 2023. T Varela; J Santos; A Rodriguez; V Pinto; D Varela; Conceição, Natércia; ML Cancela. "Screening of drugs in zebrafish model to rescue cdkl5 deficiency disorder phenotype". Paper presented in IV International Meeting of the Portuguese Society of Genetics, 2023. M Vitorino; Conceição, Natércia; Tiscornia, Gustavo; Cancela, ML. "Using Acomys cahirinus as model to identify the role of Gla proteins in tissue regeneration". Paper presented in IV International Meeting of the Portuguese Society of Genetics, 2023. M Simão; L Miguel; Conceição, Natércia; J Santos; ML Cancela. "Bioinformatic characterization of two MGP mutant proteins expressed in zebrafish (Danio rerio)". Paper presented in IV International Meeting of the Portuguese Society of Genetics, 2023. T Varela; D Varela; Conceição, Natércia; ML Cancela. "Zebrafish mutant for CDKL5 display neuronal defects resembling CDKL5 deficiency disorder". Paper presented in FENS Regional Meeting 2023, 2023. A Campos; M Vitorino; Conceição, Natércia. "The use of Acomys cahirinus to study the role of Matrix Gla Protein in regeneration". Paper presented in MEEting 2023, 2023. D Varela; T Varela; Conceição, Natércia; ML Cancela. "Effect of bone-related transcription factors and methylation on ZNF687 transcriptional regulation". Paper presented in 50th ECTS, 2023. JMA Santos; V Laizé; PJ Gavaia; Conceição, Natércia; ML Cancela. "Zebrafish models to study ectopic calcification and calcium associated pathologies". Paper presented in European Crystal Network, 2023. T Varela; D Varela; Conceição, Natércia; ML Cancela. "Zebrafish Mutant for Cdkl5 Mimics Phenotypes Associated with Human CDKL5 Deficiency Disorder". Paper presented in 26th Annual Meeting Sociedade Portuguesa de Genética Humana, 2022. D Varela; T Varela; Conceição, Natércia; ML Cancela. "Regulation of Znf687 during Osteoblast Differentiation". Paper presented in 26th Annual Meeting Sociedade Portuguesa de Genética Humana, 2022. B Calado; A Chenneviére; D Varela; Cancela, ML; Conceição, Natércia. "Bioinformatic Analysis of DCST2 gene structure and function: A Potential Contributor in Bone Development". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology, 6th Conference, 2022. JMA Santos; C Rodrigues; RCR Abreu; I Borges; Conceição, Natércia; Gavaia, PJ; V laizé; Cancela ML. "Loss of Elastin function is associated with improper calcium metabolism in zebrafish". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology, 6th Conference, 2022. T Varela; D Varela; Conceição, Natércia; ML Cancela. "Zebrafish model for the screening of drugs to rescue cdkl5 deficiency disorder phenotypes". Paper presented in 2022 CDKL5 Forum, 2022. JMA Santos; RCR Abreu; C Rodrigues; I Borges; Conceição, Natércia; Gavaia, PJ; Laizé, V; Cancela, ML. "Zebrafish model to study mechanisms of calcium metabolism in elastin associated pathologies". Paper presented in ABC Days – V Annual Meeting of Algarve Biomedical Center, 2022. T Varela; D Varela; Conceição, Natércia; Cancela, ML. "cdkl5 mutant zebrafish recapitulates key phenotypes of CDKL5 deficiency disorder". Paper presented in ABC Days – V Annual Meeting of Algarve Biomedical Center, 2022. D Varela; T Varela; Conceição, Natércia; Cancela, ML. "Involvement of ZNF687, a gene associated with Paget disease of bone, in osteoblastogenesis and osteoclastogenesis". Paper presented in ABC Days – V Annual Meeting of Algarve Biomedical Center, 2022. M Vitorino; Conceição, Natércia; D Varela; G Tiscornia; Cancela, ML. "The role of MGP involved in Acomys cahirinus ear regeneration". Paper presented in ABC Days – V Annual Meeting of Algarve Biomedical Center, 2022. Aranyi, Tamas; Conceição, Natércia; M Jacinto; Kempf, Hervé; Leftheriotis, Georges; L Martin; P Valdivielso; OM Vanakker. "ISSEC: An International Scientific Society of Ectopic Calcification dedicated to the advance of knowledge and awareness for ectopic calcification diseases". Paper presented in INTEC kick-off meeting, 2022. M Vitorino; Conceição, Natércia; D Varela; Tiscornia, Gustavo; ML Cancela. "The use of Acomys cahirinus to study the role of Matrix Gla Protein in regeneration". Paper presented in INTEC kick-off meeting, 2022. D Varela; T Varela; Conceição, Natércia; Cancela, ML. "ZNF687 gene expression and methylation in osteoblastogenesis". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. T Varela; D Varela; Conceição, Natércia; ML Cancela. "Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. Caiado, H.; Conceição, Natércia; Cancela, ML. "Cancer-related transcription factors regulate MGP promoter activity". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. M Vitorino; Conceição, Natércia; D Varela; G Tiscornia; ML Cancela. "Is MGP involved in Acomys cahirinus ear regeneration?". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. AS Alfaia; Conceição, Natércia; G Sequeira; P Carvalho; V Teixeira; C Ribeiro; Cancela, ML. "Genetic analysis of Optineurin variants in Paget Disease of Bone patients from the south and center of Portugal". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. JMA Santos; RCR Abreu; C Rodrigues; I Borges; Conceição, Natércia; Gavaia, PJ; Laizé, V; ML Cancela. "Zebrafish model to study mechanisms of ectopic mineralization associated to elastinopathies.". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. M Simão; Conceição, Natércia; Cancela, ML. "Impact of Lab-it to consolidate molecular genetics concepts in high schools within the context of biomedical sciences". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. T Aranyi; Conceição, Natércia; M Jacinto; H Kempf; Leftheriotis, Georges; L Martin; Valdivielso, Pedro; OM Vanakker. "ISSEC: An International Scientific Society of Ectopic Calcification dedicated to the advance of knowledge and awareness for ectopic calcification diseases". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. T Varela; D Varela; Conceição, Natércia; Cancela, ML. "Zebrafish: a promising animal model to study CDKL5 deficiency disorder". Paper presented in 11th European conference on rare diseases & orphan products, 2022. Tatiana Varela; Débora Varela; Conceição, Natércia; M Leonor Cancela. "Involvement of cdkl5 gene during osteoblast proliferation and differentiation.". Paper presented in Ciência 2022 ¿ Encontro com a Ciência e Tecnologia em Portugal, 2022. R Soares; Cancela, ML; Conceição, Natércia. "Osteogenesis Imperfecta. Consequências na função da proteína". Paper presented in MEEting 2022, 2022. M Custódio; C Rodrigues; Conceição, Natércia; Gavaia, P. "Modelos de osteogénese imperfeita em peixe-zebra: comparação entre mutações e fenótipos". Paper presented in MEEting 2022, 2022. Tatiana Varela; Gil Martins; Débora Varela; Conceição, Natércia; M Leonor Cancela. Corresponding author: Tatiana Varela. "Characterization of zebrafish cdkl5 knockdown using a morpholino approach". Paper presented in XXI National Congress of Biochemistry, 2021. M Vitorino; N Conceição; D Varela; G Tiscornia; Cancela, ML. "Involvement of MGP in African Spiny mice ear regeneration". Paper presented in XXI SPB- National Congress of Biochemistry, 2021. T Varela; D Varela; G Martins; N Conceição; Cancela, ML. "Characterization of cdkl5 knockdown zebrafish using a morpholino approach". Paper presented in XXI SPB- National Congress of Biochemistry, 2021. D Varela; N Conceição; Cancela, ML. "Involvement of Znf687 gene during osteoblast proliferation and differentiation". Paper presented in XXI SPB- National Congress of Biochemistry, 2021. D Varela; T Varela; J Rosa; A Nunes; N Conceição; Cancela ML. "Zebrafish as a model to assess the effects of thalidomide in limb development". Paper presented in ECTS 2021 Digital, 2021. Liliane Ferrador; Naina Andrade; Ana Gomes; José, Mélissa; Inês C Leal; Djanira Nascimento; João P. M. Reis; et al. "Zebrafish as a model to study the functional roles of hecw2". Paper presented in Annual Meeting of the Portuguese Society of Genetics, 2021. T Varela; G Martins; D Varela; M Vitorino; Conceição, Natércia; Cancela, ML. "The use of dominant negative strategy in zebrafish to study CDKL5 Deficiency Disorder". Paper presented in 24th Annual Meeting Sociedade Portuguesa de Genética Humana, 2020. D Varela; Conceição, Natércia; Cancela, ML. "Regulation of ZNF687 by the bone-related transcription factors DLX5 and HOXD13 through binding sites overlapping CpG sites". Paper presented in 24th Annual Meeting Sociedade Portuguesa de Genética Humana, 2020. Caiado, H.; Conceição, Natércia; D Tiago; A Marreiros; AM Vaz; A Antunes; Guerreiro, H; P Caldeira; Cancela, ML. "Contribution of MGP, FGF2 and RUNX2 as important predictor factors to differentiate prognosis among patients with colorectal adenocarcinomas". Paper presented in Encontro Ciência ´20, 2020. T Varela; G Martins; D Varela; M Vitorino; Conceição, Natércia; Cancela, ML. "Zebrafish cdkl5 mutant as a model to study CDKL5 deficiency disorder". Paper presented in RARE Drug Development Symposium, 2020. AS Alfaia; Conceição, Natércia; G Sequeira; P Carvalho; V Teixeira; C Ribeiro; ML Cancela. "Genetic analysis of Optineurin and APEX variants in two families from south-center of Portugal with Paget Disease of Bone history". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. H Caiado; Conceição, Natércia; ML Cancela. "Regulation of Matrix Gla Protein gene through epigenetic mechanisms in Bladder Cancer". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. H Caiado; Conceição, Natércia; D Tiago; A Marreiros; AM Vaz; A Antunes; H Guerreiro; P Caldeira; ML Cancela. "MGP, FGF2 and RUNX2 as important predictor factors to differentiate colorectal adenocarcinoma prognosis amongst patients". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Conceição, Natércia; M Loiodice. "Overlapping genes, alternative promoters and transcriptional regulation: the case of OPTN and CCDC3". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. AIM Marques; I Meirinho; J Mustacová; AI Favinha; EG Dimou; ALC Figueiredo; D Shkabura; et al. "Danio rerio as a model to study ERCC1 function in bone formation". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Débora Varela; Tatiana Varela; P Azevedo; A Ferreira; A.Silva; Nuno Marques; A Camacho; et al. "Two novel TBX5 mutations in Holt-Oram syndrome patients with different clinical manifestations". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Débora Varela; Tatiana Varela; J Rosa; A Nunes; Conceição, Natércia; ML Cancela. "The effect of thalidomide on phenotype and gene expression in zebrafish". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Débora Varela; J Zortéa; J Rosa; A Nunes; Conceição, Natércia; ML Cancela. "Functionality of binding sites for bone-related transcription factors overlapping CpG sites on ZNF687, a gene associated with Paget’s disease of bone". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Tatiana Varela; G Martins; Débora Varela; M Vitorino; Conceição, Natércia; ML Cancela. "Contribution to validate zebrafish as model for CDKL5 deficiency disorder using a morpholino-mediated approach". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Tatiana Varela; IS Morais; A Nechaeva; ML Cancela; L Faísca; A Reis; Conceição, Natércia. "Study of the candidate gene KIAA0319 for dyslexia in the Portuguese population". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Tatiana Varela; Martins, Gil; Débora Varela; Vitorino, Marta; Conceição, Natércia; M Leonor Cancela. "Contribution to validate zebrafish as a model for CDKL5 deficiency disorder using a morpholino-mediated approach". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. T Gago; H Caiado; Conceição, Natércia; D Tiago; AM Vaz; S Vicente; JL Enriquez; et al. "Expressão do gene MGP no Carcinoma Colorretal: Haverá relação com o CA 19.9?". Paper presented in XXXIV Reunião Anual NGHD Núcleo de Gastroenterologia dos Hospitais Distritais, 2019. Conceição, Natércia; Tatiana Varela; G Martins; Débora Varela; M Vitorino; ML Cancela. "Zebrafish: an interesting model to study CDKL5 deficiency disorder". Paper presented in 23nd Annual Meeting of the Portuguese Society of Human Genetics, 2019. H Caiado; Conceição, Natércia; ML Cancela. "Epigenetic regulation of Matrix Gla Protein gene through miR-155 in Breast Cancer". Paper presented in 3rd jornadas do Algarve Biomedical Center, 2019. Tatiana Varela; M Vitorino; Conceição, Natércia; ML Cancela. "Zebrafish as a model to study CDKL5 deficiency disorder". Paper presented in 3rd jornadas do Algarve Biomedical Center, 2019. Conceição, Natércia; Débora Varela; Tatiana Varela; P Azevedo; S. Pereira; A Camacho; I Jesus; ML Cancela. "Functional analysis of a novel TBX5 c.905delA mutation present in a Holt-Oram syndrome patient". Paper presented in 3rd Jornadas do Algarve Biomedical Center, 2019. M Loiodice; Conceição, Natércia. "Analysis of transcription co-regulation of two overlapping human genes, CCDC3 and OPTN". Paper presented in 3rd Jornadas do Algarve Biomedical Center, 2019. AS Alfaia; Conceição, Natércia; G Sequeira; P Carvalho; C Ribeiro. "Genetic analysis of Optineurin variants in Paget’s patients from South of Portugal". Paper presented in 3rd Jornadas do Algarve Biomedical Center, 2019. Conceição, Natércia; ML Cancela; Débora Varela; Varela, Débora; Conceição, Natércia; Cancela, M. Leonor. "Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors". Paper presented in VIII National RNA Meeting ptRNA2019, 2019. 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1882 Conceição, Natércia; Tatiana Varela; V Laizé; ML Cancela. "DUSP4 expression in colorectal cancer and insight into its transcriptional regulation". Paper presented in VIII National RNA Meeting ptRNA2019, 2019. B Komazec; R Cerqueira; S Horta; SD Major; V Rossetto; A Nunes; Tatiana Varela; Cancela ML; Conceição, Natércia. "Histone H3F3A is encoded by different transcripts with distinct 5´-UTRs in both human and zebrafish". Paper presented in VIII National RNA Meeting ptRNA2019, 2019. H Caiado; Conceição, Natércia; ML Cancela. "Correlation between Matrix Gla Protein gene and microRNA 155 expression in cancer". Paper presented in VIII National RNA Meeting ptRNA2019, 2019. C Fazenda; M Vitorino; Conceição, Natércia. "Investigation of Gla Rich Protein role using a knockout mice". Paper presented in 5th MEEting of MIM, 2019. G Sequeira; P Carvalho; C Ribeiro; AS Alfaia; Conceição, Natércia; ML Cancela. "Characterization of Paget´s Disease of Bone Patients from the South of Portugal (Algarve and Alentejo) – Clinical and Genetic Aspects". Paper presented in ACR/ARHP Annual Meeting, 2018. H Caiado; R Reis; T Authier; ML Cancela; Conceição, Natércia. "Analysis of ZNF687 gene expression in different tumors using the cancer genome atlas database". Paper presented in Annual Meeting 2018 Portuguese Society of Genetics, 2018. Conceição, Natércia; H Caiado; A Marreiros; ML Cancela. "Regulation of the Matrix Gla Protein through epigenetic mechanisms". Paper presented in Annual Meeting 2018 Portuguese Society of Genetics, 2018. S Serrano; T Authier; ML Cancela; Conceição, Natércia. "Análise das regiões promotoras dos genes znf687a e znf687b do peixe-zebra (Danio rerio)". Paper presented in Aniversário do curso de bioquímica, 2018. R arroja; T Authier; Conceição, Natércia; ML Cancela. "Estudo da análise do promotor do gene ZNF687 humano e identificação de fatores de transcrição". Paper presented in Aniversário do curso de bioquímica, 2018. T Authier; S Serrano; AR Pinho; ML Cancela; Conceição, Natércia. "Study of transcriptional regulation of zebrafish orthologues of human ZNF687 gene". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology, 5th Conference, 2018. W Zhang; HG Silva; C Viana; PJS Duarte; E Veiga; B Bica; I de Matos; et al. "Zebrafish as a model to study PHYH related pathologies". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology, 5th Conference, 2018. Tatiana Varela; Conceição, Natércia; V Laizé; P Caldeira; A Marreiros; H Guerreiro; ML Cancela. "DUSP4 transcripts expression as a potential biomarker for colorectal cancer". Paper presented in 2nd jornadas do Algarve Biomedical Center, 2018. Conceição, Natércia; Débora Varela; A Ferreira; N. Marques; AP Silva; ML Cancela. "Functional analysis of a novel TBX5 c.246_249delGATG mutation present in a Holt-Oram syndrome patient". Paper presented in , 2nd jornadas do Algarve Biomedical Center, 2018. Conceição, Natércia; H Caiado; D Tiago; A Marreiros; AM Vaz; S Vicente; H Guerreiro; P Caldeira; ML Cancela. "MGP overexpression is associated with a worse prognosis and survival outcome in colorectal adenocarcinomas". Paper presented in 2nd jornadas do Algarve Biomedical Center, 2018. S Norali; A Reis; Conceição, Natércia. "The genetics of reading abilities in adults". Paper presented in 4th MEEting of MIM, 2018. I Bodião; ML Cancela; Conceição, Natércia. "On using Feature Descriptors asScreening for detection of SNPs within the PDB6 locus associated with Paget disease of bone". Paper presented in 4th MEEting of MIM, 2018. 10.1049/ic.2016.0080 T Authier; Conceição, Natércia; ML Cancela. "Comparative analysis of the zinc finger protein ZNF687 throughout evolution". Paper presented in X Encontro Nacional de Biologia Evolutiva, 2017. Conceição, Natércia; N Carrasco; Pedro Castelo-Branco; ML Cancela. "Molecular basis for the epigenetic regulation of MGP in cancer". Paper presented in 3th MEEting of MIM, 2017. T Franco; VL Henriques; DFC Duarte; LA Viagem; I Maia; S Mariano; IM Araujo; Conceição, Natércia. "Bioinformatic analysis of Foxp2 gene in zebrafish (Danio rerio)". Paper presented in XLI Jornadas Portuguesas de Genética, 2017. Franco, Telma; Henriques, Vera; Duarte, Daniel; Viagem, Leonildo; Maia, Inês B.; Mariano, Sara; Araújo, Inês Maria; Conceição, Natércia. "Bioinformatic Analysis of Foxp2 gene in Zebrafish (Danio rerio)". Paper presented in XLI Jornadas Portuguesas de Genética, 2017. ML Cancela; Débora Varela; Conceição, Natércia. "Initial validation of zebrafish as model for Holt-Oram syndrome". Paper presented in FishBone 2017 ECTS 2017 Pre-congress, 2017. H Caiado; Conceição, Natércia; D Tiago; S Vicente; JL Enriquez; AM Vaz; A Antunes; et al. "Evaluation of MGP gene expression in colon cancer". Paper presented in XIX National Congress of Biochemistry, 2016. S. Teixeira; Conceição, Natércia. "Regulatory sites of the OPTN and CCDC3 genes in connection with Paget’s disease of bone". Paper presented in 2nd MEEting of MIM, 2016. 10.1142/9781848162525_0017 AS Sofia; S Mariano; Tatiana Varela; JJ Matos; D Varela; T Authier; ML Cancela; Conceição, Natércia. "Bioinformatic Analysis of CCDC3 gene: A Potential Contributor for Paget Disease of Bone?". Paper presented in XL Jornadas Portuguesas de Genética, 2016. IAL Silva; L Michou; ML Cancela; Conceição, Natércia. "Functional study of OPTN promoter: new OPTN regulators and effect of genetic variants". Paper presented in XL Jornadas Portuguesas de Genética, 2016. M Vitorino; Conceição, Natércia; ML Cancela. "Zebrafish as model for bone diseases associated with Rett syndrome". Paper presented in XL Jornadas Portuguesas de Genética, 2016. C Fazenda; M Vitorino; A Cachucho; L Shu-Wha; PJ Gavaia; Conceição, Natércia; ML Cancela. "Gla-rich protein deficient mice born from homozygous mutant progenitors show cartilage and bone defects". Paper presented in XL Jornadas Portuguesas de Genética, 2016. VP Roberto; Conceição, Natércia; MJ Nunes; E. Rodrigues; ML Cancela; DM Tiago. "miR-214: A Novel Regulator of Chondrogenesis?". Paper presented in ECST2016, 2016. IAL Silva; Conceição, Natércia; L Michou; ML Cancela. "Comparative analysis of human and zebrafish OPTN: molecular and evolutionary perspectives". Paper presented in ECST2016, 2016. IAL Silva; Conceição, Natércia; ML Cancela. "OPTN and CCDC3 share a bidirectional promoter region that is regulated by NF-kB". Paper presented in ECSC2016, 2016. Conceição, Natércia; C Fazenda; G Martins; PJ Gavaia; ML Cancela. "Study of transcriptional regulation and function of gla rich protein gene in zebrafish". Paper presented in 9th European Zebrafish Meeting, 2015. JC Nogueira; Conceição, Natércia; ML Cancela. "MRD20 or Mental Retardation Autosomal Dominant: contribution to the study of a recently identified human mutation". Paper presented in 1st MEEting of MIM, 2015. D Marques; Conceição, Natércia; ML Cancela. "Paget’s disease of bone: contribution to the study of human locus PDB6". Paper presented in 1st MEEting of MIM, 2015. IAL Silva; Conceição, Natércia; L Michou; ML Cancela. "Zebrafish as an animal model to study OPTN role in Paget´s disease of bone". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology, 4th Conference, 2015. Conceição, Natércia; A Adrião; M Grazina; ML Cancela. "Towards validation of zebrafish as a model to study MEF2C related pathologies". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology, 4th Conference, 2015. 10.1109/icstw.2016.7 C Fazenda; G Martins; PJ Gavaia; ML Cancela; Conceição, Natércia. "Establishment of transgenic zebrafish lines capable of conditionally inducing expression of Gla-rich protein". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology, 4th Conference, 2015. M Vitorino; Conceição, Natércia; A Adrião; ML Cancela. "Zebrafish as a model to study bone diseases associated with Rett syndrome". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology, 4th Conference, 2015. IAL Silva; Conceição, Natércia; L Michou; ML Cancela. "Functional study of Optineurin (OPTN) variants associated with Paget’s disease of bone". Paper presented in ASBMR, 2014. C Fazenda; Conceição, Natércia; ML Cancela. "Transcription factors from Sox family regulate zebrafish Gla-rich protein 2 gene". Paper presented in YSF FEBS2014, 2014. IAL Silva; Conceição, Natércia; L Michou; ML Cancela. "Functional analysis of a promoter polymorphism of Optineurin, a gene to associated to Paget’s Disease of Bone". Paper presented in ECTS2014, 2014. Conceição, Natércia; A Adrião; ML Cancela. "Identification of two functional promoters for zebrafish mef2cb gene". Paper presented in 8th European Zebrafish Meeting, 2013. C Fazenda; Conceição, Natércia; ML Cancela. "Transcriptional regulation of the zebrafish Gla-rich protein 2 (grp2) gene". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2013. IAL Silva; Conceição, Natércia; L Michou; ML Cancela. "Single nucleotide polymorphisms identification and functional analysis in PDB6 locus – A target locus for Paget’s Disease of Bone". Paper presented in ECTS2013, 2013. Conceição, Natércia; B Simões; ML Cancela. "Functional analysis of the two Runx3 promoters in osseous and non-osseous cells: implications for tissue/differentiation specific transcription of distinct isoforms". Paper presented in ECST2013, 2013. Silva, Iris AL; Conceição, Natércia; Michou, Laëtitia; Cancela, M. Leonor. "Single Nucleotide Polymorphism identification and functional analysis in PDB6 locus - A target locus for Paget¿s disease of Bone". Paper presented in European Calcified Tissue Society Meeting 2013, Lisbon, Portugal, 18-21 May, 2013, 2013. B Simões; Conceição, Natércia; ML Cancela. "Molecular characterization of CBFß Gene and identification of new transcription variants: Implications for function". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2013. A Adrião; PJ Gavaia; Conceição, Natércia; ML Cancela. "Use of reporter lines to visualize bone and cartilage phenotypes in the zebrafish mef2cab1086 mutant line". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2013. IAL Silva; Conceição, Natércia; ML Cancela. "Can zebrafish be a valid model to study Paget's Disease of Bone?". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2013. A Adrião; Conceição, Natércia; ML Cancela. "Zebrafish as a model to study craniofacial phenotypes related to human MEF2C mutations". Paper presented in 47th Annual Meeting of the European Society for Clinical Investigation (ESCI), 2013. B Simões; Conceição, Natércia; RN Kelsh; ML Cancela. "Identification and in vitro/in vivo functional characterization of zebrafish runx3 alternative promoters". Paper presented in FEBS International Workshop “New Developments in RNA Biology", 2012. D Tiago; Conceição, Natércia; V Laizé; ML Cancela. "Evidences for post-transcriptional regulation of MGP: can microRNAs regulate tissue calcification?". Paper presented in FEBS International Workshop “New Developments in RNA Biology", 2012. 10.1158/1538-7445.fbcr13-ia5 AP Gandolfo; IAL Silva; ML Cancela; Conceição, Natércia. "Zebrafish: a good model to study XPG pathologies?". Paper presented in XXXVII JPG Congress, 2012. 10.1158/1538-7445.am2017-804 IAL Silva; R Leite; ML Cancela; Conceição, Natércia. "TFIIH is remarkably conserved between zebrafish and human". Paper presented in 5Th Clinical Biochemistry Workshop, 2012. A Adrião; Conceição, Natércia; IAL Silva; M Grazina; ML Cancela. "Validation of zebrafish as a model to study mef2c pathologies". Paper presented in 5Th Clinical Biochemistry Workshop, 2012. Silva, Iris AL; Leite, Ricardo B; Cancela, M. Leonor; Conceição, Natércia. "TFIIH Is Remarkably Conserved Between Zebrafish And Human". Paper presented in V Clinical Biochemistry Workshop, Coimbra, Portugal, 27 January, 2012, 2012. A Adrião; Conceição, Natércia; M Grazina; ML Cancela. "Expression, regulation and interaction with target genes in health and disease". Paper presented in DCBM Ph.D. student seminars, 2011. C Fazenda; ML Cancela; Conceição, Natércia. "Molecular characterization and expression of a novel Gla-containing protein, Gla-rich protein (Grp), in zebrafish". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2011. IAL Silva; ML Cancela; Conceição, Natércia. "xpd mutations in zebrafish: is there a bone phenotype?". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2011. C Fazenda; Conceição, Natércia; ML Cancela. "Identification of two isoforms of Gla Rich Protein (GRP) in zebrafish and its molecular characterization". Paper presented in XVII National Congress of Biochemistry, 2010. 10.1158/1538-7445.am2011-3895 B Simões; Conceição, Natércia; R Kelsh; ML Cancela. "runx3 promoter analysis and expression patterns in tissues and during development of zebrafish". Paper presented in XVII National Congress of Biochemistry, 2010. IAL Silva; C Fazenda; Conceição, Natércia; ML Cancela. "Study of the Xeroderma pigmentosum D (XPD) expression in zebrafish". Paper presented in XVII National Congress of Biochemistry, 2010. C Fazenda; Conceição, Natércia; ML Cancela. "Molecular characterization of gla rich protein (GRP) gene expression and function using zebrafish as model system". Paper presented in Biomedical Sciences Ph.D. students seminars, 2010. M Sousa; C Fazenda; Conceição, Natércia; ML Cancela. "Matrix Gla Protein is a target gene for transcription factor MEF2C". Paper presented in Science Meeting 2010, 2010. Conceição, Natércia; A Lelo; JP Pinto; ML Cancela. "Regulation of hepcidin expression: in silico promoter analysis". Paper presented in SINAL 2010, 2010. Conceição, Natércia; C Fazenda; C Viegas; R Leite; ML Cancela. "Promoter analysis of cartilage-expressed genes". Paper presented in 4Th Clinical Biochemistry Workshop, 2010. B Simões; Conceição, Natércia; ML Cancela; RN Kelsh. "Investigation of runx3 expression pattern and function in zebrafish peripheral nervous system development". Paper presented in 6th European Zebrafish Genetics and Development Meeting, 2009. C Fazenda; CSB Viegas; Conceição, Natércia; DC Simes; ML Cancela. "Development of molecular and cellular tools to study the function of skeletal Gla-containing proteins in sturgeon". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2009. Conceição, Natércia; C Cox; B Simões; M Viegas; ML Cancela. "Comparative promoter analysis and its application in analysis of cartilage-expressed genes regulation". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2009. B Simões; D Rodrigues; Conceição, Natércia; RN Kelsh; ML Cancela. "Spatial-temporal expression of Runx3 during early zebrafish development and in silico and in vitro analysis of its promoter regions". Paper presented in XVIth National Congress of Biochemistry, 2008. Conceição, Natércia; C Cox; B Simões; M Viegas; ML Cancela. "Computational identification of regulatory motifs in cartilage-expressed genes using zebrafish as an in vivo model". Paper presented in XVIth National Congress of Biochemistry, 2008. C Fazenda; Conceição, Natércia; ML Cancela. "Possible regulation of the matrix gla protein gene by the transcription factor mef2c". Paper presented in XVIth National Congress of Biochemistry, 2008. Conceição, Natércia; C Fazenda; B Simões; ML Cancela. "Transcriptional regulation of the Xenopus laevis Matrix Gla Protein gene expression". Paper presented in 35th European Symposium on Calcified Tissues, 2008. Conceição, Natércia; V Laizé; ML Cancela. "Regulation of Matrix Gla Protein gene expression in teleost fish sparus aurata". Paper presented in MGE - Marine Genomics Europe Final Assembly, 2008. Conceição, Natércia; B Simões; ML Cancela; RN Kelsh. "runx3 structure and function in zebrafish neural crest: expression pattern and morpholino knockdown". Paper presented in Seminários de Mar e Ambiente 2008, 2008. Conceição, Natércia; C Fazenda; B Simões; ML Cancela. "Identification of a new Runx2 isoform in Xenopus laevis: molecular organization, tissue distribution and effect on MGP gene transcription". Paper presented in MICRO’07 BIOTEC’07-XXXIII JPG Congress, 2007. M Viegas; Conceição, Natércia; J Fidalgo; ML Cancela. "Characterization of a Xenopus laevis bone derived cell line, X1, capable of mineralizing in vitro". Paper presented in MICRO’07 BIOTEC’07-XXXIII JPG Congress, 2007. Conceição, Natércia; C Fazenda; B Simões; ML Cancela. "Identification of new Runx2 isoforms from Xenopus laevis capable of inducing MGP gene expression in vitro". Paper presented in IVth National RNA Meeting, 2007. B Simões; Conceição, Natércia; J Belo; ML Cancela. "Analysis of Xenopus laevis MGP knockdown phenotype: expression pattern of developmental marker genes". Paper presented in IVth National RNA Meeting, 2007. B Simões; Conceição, Natércia; ML Cancela; RN Kelsh. "Effects of Runx3 isoforms on distribution and migration of zebrafish neural crest cells". Paper presented in Workshop “Mechanisms of early development: cell fate determination, morphogenesis and patterning, 2007. B Simões; A.Silva; M Vitorino; Conceição, Natércia; J Belo; ML Cancela. "Spatio-temporal pattern of expression and regulation of matrix Gla protein (MGP) during early development in Xenopus laevis". Paper presented in 32rd FEBS Congress, 2007. 10.1109/icpr.2008.4761009 Conceição, Natércia; B Simões; C Fazenda; ML Cancela. "Runx2-mediated regulation of the Matrix Gla Protein gene". Paper presented in 32rd FEBS Congress, 2007. B Simões; A.Silva; Conceição, Natércia; M Vitorino; J. Belo; ML Cancela. "Spatial-temporal pattern of expression and regulation of matrix Gla protein (MGP) during early development in Xenopus laevis". Paper presented in XV National Congress of Biochemistry, 2006. Conceição, Natércia; J Fidalgo; B Simões; ML Cancela. "Regulation of the Xenopus laevis MGP promoters by transcription factors: NF-AT and Runx2". Paper presented in Workshop Mineralised tissue formation, regeneration, and repair, 2006. Conceição, Natércia; A.Silva; B Simões; J. Belo; ML Cancela. ", Mapping of the cis-regulatory elements in the XlMGP promoters by cell culture experiments and microinjection of Xenopus laevis embryos using deletion mutant constructs". Paper presented in 4th Meeting of the Centre of Marine and Environmental Investigation, 2006. AR Pombinho; V Laizé; Conceição, Natércia; ML Cancela. "Regulators of MGP gene expression in Sparus aurata VSa13 bone-derived cell line". Paper presented in Seminários “Mar e Ambiente”, 2006. B Simões; Conceição, Natércia; CSB Viegas; JP Pinto; P Gavaia; RN Kelsh; ML Cancela. "Gene structure, Runx2-dependent regulation and spatial-temporal expression of collagen X¿1 during early zebrafish development". Paper presented in Microscopy in Motion - XLth Meeting of the SPME-BC, 2005. JP Pinto; Conceição, Natércia; CSB Viegas; RB Leite; RN Kelsh; ML Cancela. "Identification of a new pebp2¿A2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro". Paper presented in XIV National Congress of Biochemistry, 2004. J Fidalgo; Conceição, Natércia; J Pinto; ML Cancela. "Hormonal regulation of Matrix Gla Protein expression in a Xenopus laevis bone-derived cell culture". Paper presented in XIV National Congress of Biochemistry, 2004. AR Pombinho; V Laizé; Conceição, Natércia; ML Cancela. "Regulation of matrix Gla protein gene expression in a fish bone-derived cell line". Paper presented in XIV National Congress of Biochemistry, 2004. B Simões; Conceição, Natércia; CSB Viegas; JP Pinto; ML Cancela. "Molecular cloning of the zebrafish (Danio rerio) Collagen Xalpha1 cDNA and gene. Identification of promoter regulatory elements". Paper presented in XIV National Congress of Biochemistry, 2004. 10.1063/1.5000196 JP Pinto; Conceição, Natércia; PJ Gavaia; ML Cancela. "Co-localization of Matrix Gla protein gene expression and protein accumulation with cartilage distribution in the teleost fish Sparus aurata". Paper presented in XIII National Congress of Biochemistry, 2002. J Fidalgo; Conceição, Natércia; JP Pinto; ML Cancela. "Retinoic acid induction of matrix Gla protein expression in a Xenopus laevis bone derived cell line". Paper presented in XIII National Congress of Biochemistry, 2002. Conceição, Natércia; R Schule; ML Cancela. "Characterization of the 5´flanking region of the Xenopus laevis matrix Gla protein (MGP) gene". Paper presented in 27th FEBS/PABMB Meeting, 2001. ML Cancela; DC Simes; P Rodrigues; Conceição, Natércia; JP Reia; MK Williamson; PA Price. "Expression of Matrix Gla Protein (MGP) in fish and amphibian: a model system to study the evolution of MGP function". Paper presented in ASBMR 22st Annual Meeting, Metro Toronto Convention Centre, 2000. Conceição, Natércia; M Ohresser; N Henriques; Prof. Dr. Roland Schule; ML Cancela. "Molecular cloning and regulation of the Xenopus laevis Matrix Gla protein gene". Paper presented in ASBMR 21st Annual Meeting, 1999. Conceição, Natércia; NM Henriques; M Ohresser; ML Cancela. "Characterization of Matrix Gla protein (MGP) gene from Xenopus laevis (Daudin, 1802)". Paper presented in XI National Congress of Biochemistry, 1998. A Martins; P Mota; Conceição, Natércia; A Reino; A Pêgo; C Marques; V Dias; et al. "Frequência genotípica do polimorfismo do gene GSTM1 em doentes com carcinoma do pulmão, da mama, do cólon ou da prostata". Paper presented in XXX Jornadas Luso-Espanholas de Genética, 1995. 10.31792/21759766.viiisic.2019.400-404 F Regateiro; P Mota; A Martins; Conceição, Natércia; A Reino; A Pêgo; C Marques; et al. "Frequency of CYP2D6 and GSTM1 genetic Polymorphisms in normal Portuguese population and cancer patients". Paper presented in British Medical Genetics Conference, 1995.
Journal article	Helena Caiado; M. Leonor Cancela; Natércia Conceição. "Transcriptional Regulation of the Human MGP Promoter: Identification of Downstream Repressors". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms252312597. 10.3390/ijms252312597 Caiado, Helena; Cancela, M. Leonor; Conceição, Natércia. "Assessment of MGP gene expression in cancer and contribution to prognosis". Biochimie 214 (2023): 49-60. http://dx.doi.org/10.1016/j.biochi.2023.06.004. 10.1016/j.biochi.2023.06.004 Andreia Adrião; Sara Mariano; José Mariano; Paulo J. Gavaia; M. Leonor Cancela; Marta Vitorino; Natércia Conceição. "mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour". Biomolecules (2023): https://doi.org/10.3390/biom13050805. 10.3390/biom13050805 Santos, João M. A.; Laizé, Vincent; Gavaia, Paulo J.; Conceição, Natércia; Cancela, M. Leonor. "Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies". International Journal of Molecular Sciences 24 4 (2023): 3366. http://dx.doi.org/10.3390/ijms24043366. 10.3390/ijms24043366 Débora Varela; Tatiana Varela; Natércia Conceição; M. Leonor Cancela. "Regulation of human ZNF687, a gene associated with Paget's disease of bone". The International Journal of Biochemistry & Cell Biology (2023): https://doi.org/10.1016/j.biocel.2022.106332. 10.1016/j.biocel.2022.106332 Débora Varela; Tatiana Varela; Conceição, Natércia; Cancela, ML. "Análise funcional de duas novas mutações no gene TBX5 presentes em indivíduos com síndrome de Holt-Oram.". Ualgoritmo 5 1 (2023): 10-15. Published Andreia Adrião; Sara Mariano; José Mariano; Paulo Gavaia; M. Leonor Cancela; Vitorino, Marta; Conceição, Natércia. Corresponding author: Conceição, Natércia. "mef2ca and mef2cb double-mutant zebrafish show altered craniofacial phenotype and motor behaviour". Biomolecules 24 4 (2023): 3366. Published Iris A.L. Silva; Débora Varela; M. Leonor Cancela; Natércia Conceição. "Zebrafish optineurin: genomic organization and transcription regulation". Genome (2022): https://doi.org/10.1139/gen-2022-0019. 10.1139/gen-2022-0019 Simão, Márcio; Conceição, Natércia; Imaginário, Susana; Amaro, João; Cancela, Maria Leonor. "Lab-It Is Taking Molecular Genetics to School". BioChem 2 2 (2022): 160-170. http://dx.doi.org/10.3390/biochem2020011. 10.3390/biochem2020011 Varela, Tatiana; Varela, Débora; Martins, Gil; Conceição, Natércia; Cancela, M. Leonor. "Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-13364-1. 10.1038/s41598-022-13364-1 Adrião, Andreia; Santana, Isabel; Ribeiro, Carolina; Cancela, M. Leonor; Conceição, Natércia; Grazina, Manuela. "Identification of a novel mutation in MEF2C gene in an atypical patient with frontotemporal lobar degeneration". Neurological Sciences 43 1 (2022): 319-326. http://dx.doi.org/10.1007/s10072-021-05269-0. 10.1007/s10072-021-05269-0 Caiado, Helena; Conceição, Natércia; Cancela ML. "Avaliação da expressão dos genes MGP, RUNX2 e FGF2 e a sua contribuição para a distinção entre diferentes prognósticos em pacientes com adenocarcinoma colorectal.". Ualgoritmo 4 (2022): 4-8. Published Varela, Tatiana; Conceição, Natércia; Laizé, Vincent; Cancela, M. Leonor. "Transcriptional regulation of human DUSP4 gene by cancer-related transcription factors". Journal of Cellular Biochemistry 122 10 (2021): 1556-1566. http://dx.doi.org/10.1002/jcb.30078. 10.1002/jcb.30078 Varela, Débora; Varela, Tatiana; Conceição, Natércia; Ferreira, Ângela; Marques, Nuno; Silva, Ana Paula; Azevedo, Pedro; et al. "Functional analysis of two novel TBX5 variants present in individuals with Holt–Oram syndrome with different clinical manifestations". Molecular Genetics and Genomics 296 4 (2021): 809-821. http://dx.doi.org/10.1007/s00438-021-01781-2. 10.1007/s00438-021-01781-2 Cancela, M. Leonor; Laizé, Vincent; Conceição, Natércia; Kempf, Hervé; Murshed, Monzur. "Keutel Syndrome, a Review of 50 Years of Literature". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.642136. 10.3389/fcell.2021.642136 Tatiana Varela; Laizé, Vincent; Conceição, Natércia; ML Cancela. "A expressão dos transcritos do gene DUSP4 como potencial biomarcador no cancro colorretal". Ualgoritmo 3 (2021): 25-28. Caiado, Helena; Conceição, Natércia; Tiago, Daniel; Marreiros, Ana; Vicente, Susana; Enriquez, Jose Luis; Vaz, Ana Margarida; et al. "Data on the evaluation of FGF2 gene expression in Colorectal Cancer". Data in Brief 31 (2020): 105765. http://dx.doi.org/10.1016/j.dib.2020.105765. 10.1016/j.dib.2020.105765 Varela, T; Laizé, V; Conceição, Natércia; Caldeira, P; Marreiros, A; Guerreiro, H; Cancela, ML; et al. "Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer.". Biomarkers in Medicine 14 8 (2020): 639-650. doi:10.2217/bmm-2019-0369. Published • 10.2217/bmm-2019-0369 Caiado, Helena; Conceição, Natércia; Tiago, Daniel; Marreiros, Ana; Vicente, Susana; Enriquez, Jose Luis; Vaz, Ana Margarida; et al. "Evaluation of MGP gene expression in colorectal cancer". Gene 723 (2020): 144120. http://dx.doi.org/10.1016/j.gene.2019.144120. 10.1016/j.gene.2019.144120 Bäck, Magnus; Aranyi, Tamas; Cancela, M. Leonor; Carracedo, Miguel; Conceição, Natércia; Leftheriotis, Georges; Macrae, Vicky; et al. "Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet". Frontiers in Cardiovascular Medicine 5 (2019): http://dx.doi.org/10.3389/fcvm.2018.00196. 10.3389/fcvm.2018.00196 Silva IAL; Conceição N; Gagnon É; Brown JP; Cancela ML; Michou L. "Molecular effect of an OPTN common variant associated to Paget's disease of bone.". PloS one (2018): http://europepmc.org/abstract/med/29782529. 10.1371/journal.pone.0197543 Vitorino M; Cunha N; Conceição N; Cancela ML. "Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome.". Molecular biology reports (2018): http://europepmc.org/abstract/med/29752575. 10.1007/s11033-018-4180-1 Silva, I.A.L.; Conceição, N.; Gagnon, É.; Caiado, H.; Brown, J.P.; Gianfrancesco, F.; Michou, L.; Cancela, M.L.. "Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone". Biochimica et Biophysica Acta - Molecular Basis of Disease 1864 1 (2018): 143-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031788497&partnerID=MN8TOARS. 10.1016/j.bbadis.2017.10.008 FAZENDA, CINDY; Martins, Gil; Gavaia, Paulo; Leonor Cancela; Conceição, Natércia. "Generation and characterization of zebrafish transgenic lines overexpressing a heat-shock mediated Gla-rich protein". Journal of Applied Ichthyology (2018): 10.1111/JAI.13662 Tiago, D.M.; Conceição, N.; Caiado, H.; Laizé, V.; Cancela, M.L.. "Matrix Gla protein repression by MIR-155 promotes oncogenic signals in breast cancer MCF-7 cells". FEBS Letters 590 8 (2016): 1234-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962855726&partnerID=MN8TOARS. 10.1002/1873-3468.12155 Adrião, A.; Conceição, N.; Cancela, M.L.. "MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation". Archives of Biochemistry and Biophysics 591 (2016): 43-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952359771&partnerID=MN8TOARS. 10.1016/j.abb.2015.12.004 Correia, E.; Conceição, N.; Cancela, M.L.; Belo, J.A.. "Matrix Gla protein expression pattern in the early avian embryo". International Journal of Developmental Biology 60 1-3 (2016): 71-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960330410&partnerID=MN8TOARS. 10.1387/ijdb.150365jb Silva, I.A.L.; Conceição, N.. "Cloning, characterization and analysis of the 5' regulatory region of zebrafish xpd gene". Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology 185 (2015): 47-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927730995&partnerID=MN8TOARS. 10.1016/j.cbpb.2015.04.003 Simões, B.; Conceição, N.; Matias, A.C.; Bragança, J.; Kelsh, R.N.; Cancela, M.L.. "Molecular characterization of cbfß gene and identification of new transcription variants: Implications for function". Archives of Biochemistry and Biophysics 567 (2015): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921028563&partnerID=MN8TOARS. 10.1016/j.abb.2014.12.023 Silva, I.A.L.; Conceição, N.; Michou, L.; Cancela, M.L.. "Can zebrafish be a valid model to study Paget's disease of bone?". Journal of Applied Ichthyology 30 4 (2014): 678-688. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904917147&partnerID=MN8TOARS. 10.1111/jai.12523 Simões, B.; Conceição, N.; Kelsh, R.N.; Cancela, M.L.. "Identification of cis-regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: Implications for function". Journal of Applied Ichthyology 30 4 (2014): 661-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904873107&partnerID=MN8TOARS. 10.1111/jai.12536 Cancela, M.L.; Laizé, V.; Conceição, N.. "Matrix Gla protein and osteocalcin: From gene duplication to neofunctionalization". Archives of Biochemistry and Biophysics 561 (2014): 56-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907897083&partnerID=MN8TOARS. 10.1016/j.abb.2014.07.020 Silva, I.A.L.; Cox, C.J.; Leite, R.B.; Cancela, M.L.; Conceição, N.. "Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation". Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology 172-173 1 (2014): 9-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899696368&partnerID=MN8TOARS. 10.1016/j.cbpb.2014.03.007 Fazenda, C.; Conceição, N.; Cancela, M.L.. "Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene". Gene (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84936129855&partnerID=MN8TOARS. 10.1016/j.gene.2015.06.079 Conceição, N.; Viegas, M.; Fidalgo, J.; Cancela, M.L.. "Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture". Molecular and Cellular Biochemistry 373 1-2 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871780280&partnerID=MN8TOARS. 10.1007/s11010-012-1473-x Michou, L.; Conceição, N.; Morissette, J.; Gagnon, E.; Miltenberger-Miltenyi, G.; Siris, E.S.; Brown, J.P.; Cancela, M.L.. "Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone". Bone 51 4 (2012): 720-728. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865636771&partnerID=MN8TOARS. 10.1016/j.bone.2012.06.028 Leonor Cancela, M.; Conceição, N.; Laizé, V.. "Gla-rich protein, a new player in tissue calcification?". Advances in Nutrition 3 2 (2012): 174-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861321582&partnerID=MN8TOARS. 10.3945/an.111.001685 Conceição, N.; Fazenda, C.; Cancela, M.L.. "Comparative gene promoter analysis: An in silico strategy to identify candidate regulatory factors for Gla Rich Protein". Journal of Applied Ichthyology 28 3 (2012): 372-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861309532&partnerID=MN8TOARS. 10.1111/j.1439-0426.2012.02001.x Fazenda, C.; Silva, I.A.L.; Cancela, M.L.; Conceição, N.. "Molecular characterization of two paralog genes encoding Gla-rich protein (Grp) in zebrafish". Journal of Applied Ichthyology 28 3 (2012): 377-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861317124&partnerID=MN8TOARS. 10.1111/j.1439-0426.2012.02004.x Silva, I.A.L.; Cancela, M.L.; Conceição, N.. "Molecular cloning and expression analysis of XPD from zebrafish (Danio rerio)". Molecular Biology Reports 39 5 (2012): 5339-5348. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863748620&partnerID=MN8TOARS. 10.1007/s11033-011-1333-x Viegas, C.S.B.; Conceiçao, N.; Fazenda, C.; Simes, D.C.; Cancela, M.L.. "Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon (Acipenser naccarii)". Journal of Applied Ichthyology 26 2 (2010): 214-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954186984&partnerID=MN8TOARS. 10.1111/j.1439-0426.2010.01408.x Conceição, N.; Cox, C.J.; Simões, B.; Viegas, M.; Cancela, M.L.. "Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes". Journal of Applied Ichthyology 26 2 (2010): 245-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954196316&partnerID=MN8TOARS. 10.1111/j.1439-0426.2010.01415.x Fazenda, C.; Simões, B.; Kelsh, R.N.; Cancela, M.L.; Conceição, N.. "Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis". Gene 450 1-2 (2010): 94-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-72449139979&partnerID=MN8TOARS. 10.1016/j.gene.2009.10.007 Conceição, N.; Laizé, V.; Simões, B.; Pombinho, A.R.; Cancela, M.L.. "Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata". Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1779 1 (2008): 28-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-39449109869&partnerID=MN8TOARS. 10.1016/j.bbagrm.2007.11.003 Simões, B.; Conceição, N.; Viegas, C.S.B.; Pinto, J.P.; Gavaia, P.J.; Hurst, L.D.; Kelsh, R.N.; Cancela, M.L.. "Identification of a promoter element within the Zebrafish colXa1 gene responsive to Runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2aA2". Calcified Tissue International 79 4 (2006): 230-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750561072&partnerID=MN8TOARS. 10.1007/s00223-006-0111-6 Pinto, J.P.; Conceição, N.M.; Viegas, C.S.B.; Leite, R.B.; Hurst, L.D.; Kelsh, R.N.; Cancela, M.L.. "Identification of a new pebp2aA2 isoform from Zebrafish runx2 capable of inducing osteocalcin gene expression in vitro". Journal of Bone and Mineral Research 20 8 (2005): 1440-1453. http://www.scopus.com/inward/record.url?eid=2-s2.0-22744449747&partnerID=MN8TOARS. 10.1359/JBMR.050318 Conceição, N.; Silva, A.C.; Fidalgo, J.; Belo, J.A.; Cancela, M.L.. "Identification of alternative promoter usage for the matrix Gla protein gene: Evidence for differential expression during early development in Xenopus laevis". FEBS Journal 272 6 (2005): 1501-1510. http://www.scopus.com/inward/record.url?eid=2-s2.0-15944374190&partnerID=MN8TOARS. 10.1111/j.1742-4658.2005.04590.x Pinto, J.P.; Conceição, N.; Gavaia, P.J.; Cancela, M.L.. "Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata". Bone 32 3 (2003): 201-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037347260&partnerID=MN8TOARS. 10.1016/S8756-3282(02)00981-X Conceição, N.; Henriques, N.M.; Ohresser, M.C.P.; Hublitz, P.; Schüle, R.; Cancela, M.L.. "Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis: Functional analysis of the promoter identifies a calcium sensitive region required for basal activity". European Journal of Biochemistry 269 7 (2002): 1947-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036231825&partnerID=MN8TOARS. 10.1046/j.1432-1327.2002.02846.x Viegas, C.S.B.; Pinto, J.P.; Conceição, N.; Simes, D.C.; Cancela, M.L.. "Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin". Gene 289 1-2 (2002): 97-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036572833&partnerID=MN8TOARS. 10.1016/S0378-1119(02)00480-8 F.J. Regateiro; A Pêgo; P Mota; A Martins; Conceição, Natércia; F Carvalho; A Reino; et al. "Frequência genótipica e alélica do polimorfismo do gene CYP2D6 do citocromo P450 na população Portuguesa". Brotéria Genética (1995): 43-49. Published
Thesis / Dissertation	Conceição, Natércia. "Control of genetic expression of Matrix Gla protein: comparative studies in fish and amphibians". PhD, Universidade do Algarve - Campus de Gambelas, 2002. Conceição, Natércia. "Mutations and Genetic Instability in colorectal carcinoma". Master, Universidade de Coimbra, 1998. Conceição, Natércia. "Detection of the nm23 gene in breast cancer". Degree, Universidade de Coimbra, 1993.

Intellectual property

Patent

Maria Leonor Cancela da Fonseca, Vincent Laizé, Tatiana Varela and Natércia Conceição. 2019. "Utilização do DUSP4 como biomarcador no cancro colorretal.". Leonor Cancela; Conceição, Natércia; Tiago, Daniel. 2015. "Utilização da MGP como método de diagnóstico, prognostico e alvo terapêutico no cancro". Expired

Other distinction

2022	Elected Secretary of the International Scientific Society of Ectopic Calcification (ISSEC)
2020	Elected Secretary of the Portuguese Society of Genetics
2007	Honorable Mention for Best Scientific Work
2007	FEBS Bursary to attend the 32rd FEBS Congress Federation of European Biochemical Societies, United Kingdom