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Carla Vitorino (CV) graduated in Pharmaceutical Sciences in 2007 from the University of Coimbra (UC), obtained her PhD degree in Pharmaceutical Sciences, in the specialty of Pharmaceutics, in 2013. CV served as Invited Assistant Professor at the Faculty of Pharmacy of the University of Coimbra, FFUC (2014-2018), and worked as a Researcher within the framework of the project CENTRO-01-0145-FEDER-030752 (Jan-Aug 2019). Currently, she is Associate Professor, in the Pharmaceutical Technology area, at the same institution. CV is an integrated researcher at the Coimbra Chemistry Centre, currently a part of the associate laboratory Institute of Molecular Sciences (IMS). She has been working on the application of nanotechnology in drug permeation enhancement strategies for transdermal, oral, and drug delivery systems to brain targeting, which has resulted in the publication of several scientific papers in peer-reviewed high-impact journals. A highlight for publications in prestigious pharmaceutical journals (Advanced Materials, ACS Nano, Journal of Cont Release, Mat Horizons, Cancer Letters, Drug Discovery Today). It brings together vast experience in pharmaceutical technology, standing out in the areas of nanotechnology and regulation. She was the principal investigator (PI) of the PTDC / MHC-CED / 2658/2014 project, which aimed to develop nanomedicines as a therapeutic alternative in the treatment of glioblastoma, and the PI of the 01/SAICT/2021-SAICT-181224 (CCDRC), 3BBBioprinting and NANOPEP 10.54499/2022.06174.PTDC, GliomaPAD, and GliomaStent (2024.15802.PEX) aiming for new PoCs establishment. She was also co-PI of the project CENTRO-01-0145-FEDER-030752, whose main objective is the development of a multifunctional Nose-to-Brain system for the treatment of drug-resistant depression. Her main research interests are nanotechnology, controlled release, and the development of new drug delivery systems in a Quality by Design perspective. CV published 112 articles in international journals, with an h-index of 38 Google Scholar (30, Scopus), 5126 citations, edited 5 books, 6 Special Issues (3 ongoing), is the author of 24 book chapters, 3 Covers, >100 oral communications (40 oral communications per invitation), 6 conference papers/abstracts, and 95-panel communications at scientific meetings. She is a member of the editorial board of 4 journals and has been a reviewer in 23 international scientific journals. 7 International Patent applications resulted from the projects she coordinated/collaborated. Integrated the world's Top 2% Scientists list in 2021-2024 of Elsevier Editorial. Young Investigator Award of Bioinspired and Biomimetic Delivery Focus Group, CRS2021. Supervisor of PhD student awarded APV Best Thesis 2023. She has contributed to teaching at the FFUC through coordination and collaboration in 16 curricular units (4 as coordinator), of the Biomedical Pharmacy and Bioanalytical Sciences, Integrated Master in Pharmaceutical Sciences, Master in Pharmaceutical Technology (current Coordinator), NANOMED (U Paris Cité), DrugsR&D and Pharmaceutical Sciences Doctoral Programs, and supervision of undergraduate, MSc and Ph.D. students. Supervised 7 Ph.D. and 16 master's students (concluded). Currently, CV supervises 9 Ph.D. students (4 in an industry setting). Also, supervised 44 integrated master's degree students, 20 master´s (4 ongoing) and co-oriented >20 national (pre-graduated) and 14 international students (8 MSc, 2 PhD, and 4 PostDoc). She was a member of 36 doctoral juries, 20 master's juries, and >50 juries of the master's degree in pharmaceutical sciences, chemistry, and medicinal chemistry. She has collaborated with the Industry in the scope of the provision of services and consulting in the area of Pharmaceutical Technology. Has also served as evaluator in EC. Integrated 5 COST actions (MC of Net4Brain), has organized and moderated international and national congresses and is involved in several science outreach activities.
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Identification

Personal identification

Full name
Carla Vitorino

Citation names

  • Vitorino, Carla

Author identifiers

Ciência ID
6D13-3F2B-9FCB
ORCID iD
0000-0003-3424-548X

Email addresses

  • csvitorino@gmail.com (Professional)
  • csvitorino@ff.uc.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
German Beginner (A1) Beginner (A1)
Education
Degree Classification
2017
Concluded
 Ped@ES – Pedagogia no Ensino Superior (Pós-Graduação)
Universidade de Coimbra, Portugal
2016
Concluded
 Pensamento estatístico aplicado (Pós-Graduação)
Laboratory of Biostatistics and Medical Informatics LBIM), Faculty of Medicine, University of Coimbra, Portugal
2016
Concluded
 Simulação em estatística (Pós-Graduação)
Laboratory of Biostatistics and Medical Informatics LBIM), Faculty of Medicine, University of Coimbra, Portugal
2015
Concluded
 III Cell Culture and Tissue Course (Pós-Graduação)
Centre of Investigation on Environment, Genetics and Oncobiology, CIMAGO – FMUC, Portugal
2015
Concluded
 Course of Science in Laboratory Animals, Category C (Pós-Graduação)
Center for Neuroscience and cell Biology, University of Coimbra, Portugal
2015
Concluded
 CTD Module 3 – Chemistry, Manufacturing and Controls, Phagecon (Pós-Graduação)
Faculty of Pharmacy, University of Coimbra, Portugal
2013
Concluded
 Pharmacy, Pharmaceutical Technology (Doutoramento)
Major in Pharmaceutical Technology
Faculty of Pharmacy, University of Coimbra, Portugal
"Lipid nanoparticles and permeation enhancement for transdermal drug delivery" (THESIS/DISSERTATION)
 Aprovada por unanimidade, com distinção e louvor/U
2010
Concluded
 Caracterização de Partículas (Pós-Graduação)
Faculty of Pharmacy, University of Coimbra, Portugal
2010
Concluded
 COST865 2010 Training School [XVII ICB] Microencapsulation Training School (Pós-Graduação)
Bioencapsulation Research Group, France
2008
Concluded
 Farmacoeconomia (Pós-Graduação)
Faculty of Economy, University of Coimbra, Portugal
2008
Concluded
 Introdução à Farmacoeconomia: Do Ambulatório ao Hospital (Pós-Graduação)
Apifarma, Portugal
2007
Concluded
 Pharmaceutical Sciences (Licenciatura)
Faculty of Pharmacy, University of Coimbra, Portugal
 16 valores
2007
Concluded
 Formação de Investigadores – Investigator Training Program (Pós-Graduação)
Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal
2007
Concluded
 Suporte Básico de Vida (Pós-Graduação)
Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal
Affiliation

Science

Category
Host institution		 Employer
2019/01/15 - 2019/08/31 Contracted Researcher (Research) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2018 Auxiliary Researcher (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal

Teaching in Higher Education

Category
Host institution		 Employer
2024/12 - Current Associate Professor (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
2020/03/01 - 2024/12 Assistant Professor (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
2019/09/01 - 2020/02/29 Invited Assistant Professor (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
Faculty of Pharmacy, University of Coimbra, Portugal
2014/09/01 - 2018/08/31 Invited Assistant Professor (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2017 Invited Assistant Professor (University Teacher) Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2015 - 2017 Invited Assistant Professor (University Teacher) CNC.IBILI, Portugal
2011/09/01 - 2014/08/31 Invited Assistant (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
2009/09/01 - 2011/08/31 Assistant (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal

Others

Category
Host institution		 Employer
2013/07/01 - 2013/08/30 Pharmaceutical development manager Nutri.add, Portugal
2008 - 2013 -- Center of Pharmaceutical Studies, Portugal
2007/10/14 - 2008/10/14 Medical Affairs Trainee (Cardiovascular, CNS, Pain and Inflamation) Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal
2007/07/01 - 2007/09/30 Pharmacist Pharmacy Teresa Bernardes Antunes, Portugal
2007/03/19 - 2007/07/30 Trainee Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Portugal
2007/01/15 - 2007/03/15 Trainee Instituto Português de Oncologia de Coimbra - IPOFGC, Portugal
2006/10/11 - 2007/01/12 Trainee Pharmacy Rocha, Portugal
2006/06/01 - 2006/06/30 Trainee Laboratory of Clinical Analysis, Faculty of Pharmacy, University of Coimbra, Portugal
2005/07/01 - 2005/07/31 Trainee Pharmaceutical department Hospital Distrital de Mirandela, Portugal
Projects

Grant

Designation Funders
2026 - Current VITAGE - Valorização de Resíduos Agrícolas em Produtos Anti-envelhecimento
Fundação "la Caixa"
Researcher
2026 - Current GliomaPAD – Nanobot photothermally-activated device for post-resection glioblastoma therapy
Provas de Conceito Santander Universidades e Acelera@UC.
Principal investigator
2026 - Current [Hapillness] - Desenvolvimento de um sistema inovador para autoadministração oral de fármacos a animais para investigação biomédica
HaPILLness
Researcher
Ongoing
2025 - Current Nanochemothermal Stent for Enhanced Glioblastoma Treatment
2024.15802.PEX
Principal investigator
2024 - Current 3D-bioprinting of blood brain barrier for modeling lipid nanoparticle access to brain tumors
3BBBioprinting
Principal investigator
Concluded
2024 - Current Projeto HAPPYBREAD - Desenvolvimento de receitas de pão funcionalizado com óleos essenciais e plantas aromáticas, e fortificado com antioxidantes, vitamina-D e cálcio
REF 17425 - MPr-2023-8
Integration into Research Grant Fellow
Ongoing
2023/03 - Current 2022.06174.PTDC, NANOPEP-Interação calcitonina-receptor promovida por nanopartículas guiadas por péptidos como uma nova abordagem para tratamento de glioblastoma
2022.06174.PTDC
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2023 - Current PATCH: an innovative transdermal herat-targeted drug delivery strategy
EXPL
Team member
Fundação para a Ciência e a Tecnologia
2022 - Current PTDC/NAN-MAT/1431/2021, from the Portuguese Foundation for Science and Technology (FCT) and the European Community Fund (FEDER) through the COMPETE2020 program, untitled “Multifunctional cell membrane-camouflaged polymeric micelles for combination therapy of colorectal cancer”
PTDC/NAN-MAT/1431/2021
Research Technician Fellow
2021 - Current Microencapsulation of Moringa Oleifera extracts and its application in functional foods to mitigate children malnutrition in developing countries
-
Integration into Research Grant Fellow
Fundação para a Ciência e a Tecnologia
2023/01/01 - 2025/12/31 Heat-induced epithelial permeability: a nanoscale-based solution for the treatment of fungal keratitis
na
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
 Centro Hospitalar e Universitário de Coimbra EPE
Ongoing
2022 - 2024 NanoPAM - Vectorisation par nanoparticules pour l’amélioration des thérapies anticancéreuses appliquées au mélanome, Projet UP-SQUARED Appel à Projets Interne 2022
, Impulsions Interdisciplinaires – Recherche – 2IR, Université de Poitiers
Researcher
2022 - 2023 NanoLIP - Nanopartículas lipídicas sólidas para o tratamento de tumores cerebrais
01/SAICT/2021 - SAICT (Projetos de Provas de Conceito) Projeto: 181224
Principal investigator
Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
2022 - 2023 SustaINsafety - Estudo de prova de conceito para a utilização da administração intranasal como estratégia inovadora de veiculação sustentada e segura de fármacos com elevada ligação às proteínas plasmáticas, INOVC+
INOVC+
Integration into Research Grant Fellow
Concluded
2021 - 2023 Melhorar a permeabilidade do epitélio no cross-linking do colagénio corneano transepitelial: uma solução baseada na nanotecnologia
EXPL/BIA-BQM/0042/2021
Integration into Research Grant Fellow
Concluded
2018/06/22 - 2022/06/21 Development of a Novel Nose-to-Brain multifunctional nanoplatform for the treatment of Depression and prevention of pharmacoresistance development
PTDC/SAU-SER/30752/2017
Co-Principal Investigator (Co-PI)
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020/09/01 - 2021 Innovative and dual function polymeric edible films: a probiotic and antioxidant delivery food packaging system
-
Integration into Research Grant Fellow
Universidade de Coimbra
Concluded
2016 - 2019 Dual nanostructured lipid carriers as a multifunctional platform for brain tumor therapy
P2020-PTDC/CTM-NAN/2658/2014
POCI-01-0145-FEDER- 016648
P2020-PTDC/CTM-NAN/2658/2014
Principal investigator
Center for Neuroscience and cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/07/31 Interactions in polyelectrolyte complexes: simulation and experiment
PTDC/QUI-QUI/101442/2008
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Alberto A. C. C. Pais; Vitorino, Carla; Nunes, Sandra; Cova, Tânia. Artificial intelligence applied to drug product lifecycle. 2024.
    Published • https://doi.org/10.1016/C2021-0-01352-3 • Editor
  2. Vitorino, Carla; Margarida Miranda; Almeida, António; Sousa, João José. Time-proof perspectives on bioquivalence. 2023.
    Published
  3. Carla Vitorino, Carmen Balana, Célia Cabral. New Insights into Glioblastoma Diagnosis, Therapeutics and Theranostics eBook ISBN: 9780323999427. 2023.
    Published • Editor
  4. Vitorino, Carla. Nanoparticles for Brain Drug Delivery. Jenny Stanford Publishing. 2021.
    10.1201/9781003119326
  5. Carla Vitorino, João Sousa, Alberto Pais, 2015. Nova Science Publishers, Incorporated, New York.. Simvastatin delivery: Challenges and Opportunities. 2015.
Book chapter
  1. Vitorino, Carla. "Advanced delivery systems for ATRA: challenges and opportunities in pharmacokinetics and bioavailability". In Retinoic Acids in Cancer Therapy. Elsevier, 2026.
  2. Cova, Tânia; Nunes, Sandra; Vitorino, Carla; Ferreira, Márcio; Rondon-Villarreal, Paola; Pais, Alberto. "In silico approaches for polymeric nanocomposites". In In silico Approaches to Macromolecular Chemistry, 503-531. Elsevier, 2023.
    10.1016/b978-0-323-90995-2.00010-2
  3. Basso, João; Fortuna, Ana; Vitorino, Rui; Akimitsu, Nobuyoshi; Vitorino, Carla. "Non-coding RNAs in glioblastoma at a glance". In New Insights Into Glioblastoma, 477-504. Elsevier, 2023.
    10.1016/b978-0-323-99873-4.00028-1
  4. Mendes, Maria; Sousa, João; Pais, Alberto A.C.C.; Vitorino, Carla. "Theranostic strategies to potentiate glioblastoma treatment via nanotechnology: The example of gold nanoparticles". In New Insights Into Glioblastoma, 707-728. Elsevier, 2023.
    10.1016/b978-0-323-99873-4.00024-4
  5. 23- Margarida Miranda, Alberto A. C. C. Pais, Carla Vitorino. "Chapter 6. Topical bioequivalence design studies – an update". In Time-proof perspectives on bioquivalence. 2023.
  6. Mariana Neves, Margarida Miranda, João Sousa, Carla Vitorino. "Chapter 13. Physiologically-based pharmacokinetic modeling to support determination of drug product bioequivalence". In Time-proof perspectives on bioquivalence. 2023.
  7. Miranda, Margarida; Cardoso, Catarina; Vitorino, Carla. "A regulatory framework for the development of topical nanomedicines". In Theory and Applications of Nonparenteral Nanomedicines, edited by Dr. Sebastien Taurin, Prashant Kesharwani, Khaled Greish, 55-78. Netherlands: Elsevier, 2021.
    10.1016/b978-0-12-820466-5.00003-x
  8. Vitorino, Carla. "Chapter II: Nanomedicine and drug delivery approaches". In Organelle and Molecular Targeting. CRC Press, Taylor & Francis Group, 2021.
    Submitted
  9. Tânia Cova, Carla Vitorino, Márcio Ferreira, Sandra Nunes, Paola Rondon-Villarreal, Alberto Pais. "Artificial Intelligence and Quantum Computing as the next pharma disruptors". In Artificial Intelligence in Drug Design, edited by Alexander Heifetz. Springer Nature, 2021.
  10. Ferreira, Maria Inês; Cova, Tânia; Paixão, José A.; Pais, Alberto; Vitorino, Carla. "Coprecipitation synthesis, stabilization, and characterization of oleic acid-coated iron oxide nanoparticles for magnetically oriented hybrid system vectorization". In Magnetic Nanoparticle-Based Hybrid Materials, 273-301. Elsevier, 2021.
    10.1016/b978-0-12-823688-8.00033-8
  11. Mendes, Maria; Silva, Jessica; Basso, João; Vitorino, Carla. "Hybrid Nanosystems Composed by Lipid and Polymer Materials". In Functional Lipid Nanosystems in Cancer, 307-347. Jenny Stanford Publishing, 2021.
    10.1201/9781003056997-12
  12. Maria Mendes, Jessica Silva, João Torres, Carla Vitorino. "Polymer–lipid hybrid nanoparticles as an anticancer drug delivery platform". In Functional lipid nanosystems in cancer.. Singapore: Pan Stanford Publishing and CRC Press (Taylor & Francis), 2020.
    Published
  13. Basso, João; Silva, Jessica; Mendes, Maria; Sousa, João; Pais, Alberto; Vitorino, Carla. "Cell Membrane-Mimetic Nanoparticles for Cancer Treatment: What Has Been Done So Far?". In Nanoparticle Drug Delivery Systems for Cancer Treatment, edited by Hala Gali-Muhtasib, and Racha Chouaib, 75-103. Singapore: Jenny Stanford Publishing, 2020.
    10.1201/9780429341250-4
  14. Silva, Jessica; Basso, João; Mendes, Maria; Sousa, João; Pais, Alberto; Vitorino, Carla. "Tailoring drug and gene codelivery nanosystems for glioblastoma treatment". In Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents, edited by Manju Rawat Singh, 141-182. Netherlands: Elsevier, 2020.
    10.1016/b978-0-12-819666-3.00005-5
  15. Jorge, A.; Pais, A.; Vitorino, C.. "Targeted siRNA Delivery Using Lipid Nanoparticles". 259-283. 2020.
    10.1007/978-1-4939-9798-5_14
  16. João Basso, José Sereno, Ana Fortuna, Miguel Castelo-Branco, Carla Vitorino. "Establishing xenograft glioblastoma models for use in preclinical development". In Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series. Springer Nature, 2020.
    Accepted
  17. Vitorino, Carla. "Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram". In Drug Repurposing in Cancer Therapy: Approaches and Applications. Humana Press, 2020.
    Accepted
  18. Vitorino, Carla. "Chapter I. Recent trends in nanotechnology". In Nanoparticles for Brain Drug Delivery. 2020.
    Accepted
  19. Vitorino, Carla. "Recent in vitro models for the blood-brain-barrier". In Nanoparticles for Brain Drug Delivery. Elsevier, 2020.
    Accepted
  20. Mendes, Maria; Barone, Antonella; Sousa, João; Pais, Alberto; Vitorino, Carla. "Gold Nanorods as Theranostic Nanoparticles for Cancer Therapy". In Nanotheranostics, 363-404. Springer International Publishing, 2019.
    10.1007/978-3-030-29768-8_16
  21. Silva, Jessica; Miranda, Ana; Sousa, João; Pais, Alberto; Vitorino, Carla. "Impact of Immunotherapy in the Treatment of Glioblastoma". In Biopharmaceuticals. InTech, 2018.
    Published • 10.5772/intechopen.78603
  22. João Henriques, Catarina Cardoso, Carla Vitorino. "Rapid microbiological methods. They are rapid! Are they fast?". In Research Trends of Microbiology. United States: MedDocs Publishers LLC, 2018.
    Accepted
  23. Mendes, M.; Sousa, J.; Pais, A.; Vitorino, C.. "Clinical applications of nanostructured drug delivery systems: From basic research to translational medicine". 2018.
  24. Carla Vitorino, António Almeida, Alberto Pais, João Sousa. "Chapter 6 - Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical delivery systems for antioxidants. In: Andreia Ascenso, Sandra Simões, Helena Ribeiro (Eds), Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Pan Stanford Publishing Pte Ltd., Singapore, pp. 217-263. https://www.t". 2016.
  25. Vitorino, C.; Almeida, A.; Sousa, J.J.; Pais, A.. "Crossing the skin barrier: A development strategy". In Simvastatin Delivery: Challenges and Opportunities. Portugal: Nova Science Publishers, Inc, 2015.
    Published
Conference abstract
  1. Mariana Marques Ribeiro; Simões, Marco; Vitorino, Carla; Mascarenhas-Melo Filipa. "Hydrogels as promising candidates for the treatment of cutaneous wounds". Paper presented in 9th International Conference on Bio-based and Biodegradable Polymers, Biopol 2024, 2024.
  2. M. S. M. Mendes; Ramos, M. Luísa; Vitorino, Carla; Pais, Alberto. "Hybrid nanoparticles as a multifunctional platform for brain tumor". Paper presented in COST NANO2CLINIC, 2022.
  3. "Prevention of allergic contact dermatitis, myth or reality? Avoiding contact allergens: from basic research to development of a new medical device Gonçalo Brites, Isabel Ferreira, Ana Silva, M. Carrascal, Carla Vitorino, Bruno Neves, Maria Teresa Cruz Toxicology Letters 350S (2021) S1–S276 S111 P04-56 10.1016/S0378-4274(21)00508-7". 2021.
  4. Vitorino, Carla. "Designing lipid nanoparticles for intranasal delivery of antidepressants". Paper presented in Drug Delivery to the Lungs, 2019.
  5. Vitorino, Carla; Joana Gonçalves, Soraia Silva, Carla Vitorino, Gilberto Alves, Ana Fortuna. "How does the device determine nose-to-brain drug delivery to mice?". Paper presented in Delivery to the Lungs, 2019.
  6. João Sousa, Ana Miranda, Tânia Cova, Maria Mendes, Carla Vitorino, Alberto Pais. "Modeling of nanoparticle surface charge for glioblastoma treatment". Osaka, 2017.
    10.4172/2321-6212-C1-009
Conference paper
  1. Sereno J; Ramos, M. Luísa; Fortuna, Ana; Caetano Oliveira, Rui; Abrunhosa, Antero J; Castelo-Branco, Miguel; Sousa, João; Pais, A. A. C. C.; Vitorino, Carla. Corresponding author: Vitorino, Carla. "Targeting strategies for enhanced therapeutic efficacy in glioblastoma: a comprehensive in vitro and in vivo investigation". Paper presented in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienna, 2025.
  2. João Basso; Ana Fortuna; Rui Vitorino; Carla Vitorino. "Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma". 2023.
    10.3390/CSAC2023-14931
  3. Basso, João; Sousa, João; Vitorino, Rui; Fortuna, Ana; Vitorino, Carla. "Otimização da Entrega de Fármacos com Transportadores Lipídicos Nanoestruturados no Glioblastoma". Paper presented in X Congresso Iberoamericano em Ciências Farmacêuticas, 2023.
  4. Gonçalo Brites, Isabel Ferreira, Ana Silva, M. Carrascal, Carla Vitorino, Bruno Neves, Maria Teresa Cruz. "Prevention of allergic contact dermatitis, myth or reality? Avoiding contact allergens: from basic research to development of a new medical device". Paper presented in Toxicology Letters 350S (2021) S1–S276 S111 P04-56 DOI: 10.1016/S0378-4274(21)00508-7, 2021.
  5. Mendes, Maria; Basso, João; Sousa, João; Pais, Alberto; Vitorino, Carla. "Designing ultra-small nanostructured lipid carriers: critical process parameters". 2020.
    10.3390/iecp2020-08691
  6. Vitorino, Carla; Miranda, Margarida; Veloso, Cláudia; Cardoso, Catarina. "From lab to upscale - Boosting formulation performance through in vitro technologies". 2020.
    10.3390/iecp2020-08674
  7. Vitorino, Carla. "Designing Lipid Nanoparticles for Intranasal Delivery of Antidepressants". Paper presented in Drug Delivery to the Lungs 2019, Edinburgh, 2019.
    Published
  8. Joana Gonçalves, Soraia Silva, Carla Vitorino, Gilberto Alves, Ana Fortuna. "How does the device determine nose-to-brain drug delivery to mice?". Paper presented in Drug Delivery to the Lungs, 2019.
  9. Costa, Gustavo; Joao Ferreira; Vitorino, Carla; Pina, M. E.; João Sousa; Figueiredo, Isabel Vitória; Maria Teresa Batista. "In vivo topical anti-inflammatory activity of Cymbopogon citratus infusion: Flavonoids contribution". Paper presented in Iinternational Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 2014.
    Published
Conference poster
  1. Vitorino, Carla; Branco, Francisco; Sousa, João; Pais, A. A. C. C.. Corresponding author: Vitorino, Carla. "Click-to-Print 3D Gummies: A Layered Nanostructured Lipid Carrier Platform for Pediatric Brain Tumor Treatment". Paper presented in 15th International Symposium in Biomedical Polymers, 2025.
  2. Branco, Francisco; Mendes, Maria; Sousa, João; Pais, A. A. C. C.; Vitorino, Carla. Corresponding author: Vitorino, Carla. "Translating and optimizing SLN manufacturing through a Quality by Design approach". Paper presented in XXIX National Meeting of the Portuguese Chemical Society, 2025.
  3. Pinto-da-Silva, Joana; Chiarentin, Lucas; Vitorino, Carla; Figueiras, Ana; MP, Almeida; Serralheiro, Ana ; Rosa da Costa, Ana M; Grenha, Ana. Corresponding author: Pinto-da-Silva, Joana. "Spray-Dried Locust Bean Gum Microparticles for Targeted Lung Immunization". Paper presented in 12th Galenus Workshop: Bioengineering the future of drug delivery, 2025.
  4. Figueiredo, Joana; Mendes, Maria; Sousa, JJ; Vitorino, Carla. Corresponding author: Vitorino, Carla. "Microfluidics-on-a-chip for designing celecoxib-based amorphous solid dispersions". Paper presented in 12th Galenus Workshop: Bioengineering the future of drug delivery, 2025.
  5. Pinto-da-Silva, Joana; Chiarentin, Lucas; Vitorino, Carla; Figueiras, Ana; Almeida, Maria Patrícia; Serralheiro, Ana ; Rosa da Costa, Ana M; Grenha, Ana. "Spray-dried locust bean gum microparticles for immunomodulation of the lung". Paper presented in Drug Delivery to the Lungs Conference 2024, 2024.
  6. Marques Silva, Bárbara; Vitorino, Carla; Ventura, Fátima V. "CRISPR/Cas systems in HIV Management: Trend? Foresight? Applications?". Paper presented in Pharma PhDay FFUC, 2024.
  7. Maria Mendes; Cova, Tânia F. G. G.; Nunes, Sandra; Vitorino, Carla; Alberto A. C. C. Pais. "Integrating Machine Learning and Molecular Simulations to Enhance Cell-Penetrating Peptide-Modified Nanoparticles". Paper presented in BIOPOL-9th International Conference on Bio-based and Biodegradable Polymers, 2024.
  8. Mendes, Maria; Vitorino, Carla; Nunes, Sandra; Cova, Tânia F. G. G.; Alberto A. C. C. Pais. "Surface matters: The delivery dilemma using lipid nanoparticles in glioblastoma". Paper presented in RICIX- 10th Iberian Meeting on Colloids and Interfaces, 2024.
  9. Chiarentin, Lucas; Miranda, Margarida; Vera Moura ; Vitorino, Carla. "Towards the development and optimization of a laser light diffraction and static image analysis for complex semisolid formulations: An Analytical Quality by Design (AQbD) approach". Paper presented in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Viena, Austria, 2024.
  10. Basso, João; Fortuna, Ana; Vitorino, Rui; Vitorino, Carla. "Enhancing glioblastoma therapy through lipid nanoparticle-mediated drug and gene co-delivery". Paper presented in XVth SPLC-CRS Conference on Controlled Drug Delivery: "New Horizons in Drug Delivery", 2024.
  11. Branco, Francisco; Vitorino, Carla; Sousa, João; Pais, A. A. C. C.. Corresponding author: Vitorino, Carla. "Dynamic 3D bioprinted model of glioblastoma with blood-brain barrier". Paper presented in 5th SPLC-CRS Young Scientists Meeting, 2024.
  12. Figueiredo, Joana; Mendes, Maria; Sousa, JJ; Vitorino, Carla. Corresponding author: Vitorino, Carla. "Taking the most of amorphous solid dispersions using microfluidization". Paper presented in XV SPLC-CRS Conference on Controlled Drug Delivery, 2024.
  13. Basso, João; Fortuna, Ana; Vitorino, Rui; Vitorino, Carla. "Unveiling the molecular mechanisms of pitavastatin induced glioblastoma death using proteomics". Paper presented in PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences, 2023.
  14. Basso, João; Fortuna, Ana; Vitorino, Rui; Vitorino, Carla. "Decoding the molecular mechanisms of pitavastatin induced glioblastoma death through proteomics". Paper presented in ESN-ISN Neurochemistry School 2023, 2023.
  15. Sousa, Joana F.M.; Murtinho, Dina; Vitorino, Carla; Pais, Alberto A.C.C.; Valente, Artur. "How solvent and polymer concentration may improve the mechanical and conducting properties of SPEEK membranes". Paper presented in XXV Meeting of the Portuguese Electrochemical Society, 2023.
  16. Basso, João; Pais, Alberto; Fortuna, Ana; Vitorino, Rui; Vitorino, Carla. "Achieving accurate measurements without breaking the bank: A highly sensitive technique for pitavastatin quantification in human plasma". Paper presented in XXVIII Encontro nacional da Sociedade Portuguesa de Química, 2023.
  17. Basso, João; Mendes, Maria; Cova, Tânia; Nunes, Sandra; Sousa, João; Pais, Alberto; Vitorino, Carla. "Solid Lipid Based Nanoparticles for Drug Delivery". Paper presented in Delivery of RNA Therapeutics, Final DARTER Meeting, 2023.
  18. Basso, João; Fortuna, Ana; Vitorino, Rui; Vitorino, Carla. "Drug and Gene Delivery in Glioblastoma: Friends or Foes?, Delivery of RNA Therapeutics". Paper presented in Delivery of RNA Therapeutics, Final DARTER Meeting, 2023.
  19. Figueiredo, Joana; Mendes, Maria; Sousa, JJ; Vitorino, Carla. Corresponding author: Vitorino, Carla. "Enabling Technologies for Amorphous Solid Dispersions". Paper presented in XIV SPLC-CRS Conference on Controlled Drug Delivery, 2023.
  20. Figueiredo, Joana; Mendes, Maria; Sousa, JJ; Vitorino, Carla. Corresponding author: Vitorino, Carla. "Bio-enabling Technologies for Amorphous Solid Dispersions". Paper presented in X Iberoamerican Congress of Pharmaceutical Sciences, 2023.
  21. Chiarentin, Lucas; Vitorino, Carla. "Analytical quality by design approach for selecting the optimal RP-HPLC conditions for the determination of clobetasol in cream formulation". Paper presented in 12th Encontro Nacional de Cromatografia; XIV WARPA, Aveiro, Portugal, 2022.
  22. Basso, João; Pais, Alberto; Fortuna, Ana; Vitorino, Rui; Vitorino, Carla. "The quest for better treatments: a novel drug delivery approach to glioblastoma". Paper presented in IX Iberian Meeting on Colloids and Interfaces, 2022.
  23. R. Ferreira, Nuno; Fialho, Sara; Fortuna, Ana; Vitorino, Carla. "Optimizing nanostructured lipid carriers for the intra nasal administration of paroxetine and escitalopram in the treatment of depression". Paper presented in 1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal, 2022.
  24. "Optimizing nanostructured lipid carriers for the intra nasal administration of paroxetine and escitalopram in the treatment of depression Nuno R. Ferreira, Sara Fialho, Ana Fortuna, Carla Vitorino 1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal, 24 January, 2022". 2022.
  25. "Taking the most out of lipids: A systematic design of lipid-based nanoparticles - Best poster presentation award João Basso, Maria Mendes, Tânia Cova, João Sousa, Alberto Pais, Ana Fortuna, Rui Vitorino and Carla Vitorino 1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal, 24 January, 2022". 2022.
  26. "Demystifying the passage through the blood-brain barrier using CPPs Maria Mendes, Lígia Catarina Gomes-da-Silva, Luis G. Arnaut, Nuno Vale, João José Sousa, Alberto Pais, Carla Vitorino 1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal, 24 January, 2022". 2022.
  27. Basso, João; Mendes, Maria; Fortuna, Ana; Vitorino, Rui; Vitorino, Carla. "Taking the most out of lipids: A systematic design of lipid-based nanoparticles". Paper presented in 1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal, 2022.
  28. Ramos, M. Luísa; Mendes, M. S. M.; Vitorino, Carla. "A multifunctional hybrid-nanoparticle for glioblastoma chemo-photothermal synergistic therapy". Paper presented in IX Iberian Meeting on Colloids and Interfaces (RICI IX), 2022, Santiago de Compostela, 2022.
  29. Mendes, Maria; Arnaut, Luis G.; Vale, Nuno; Sousa, João José; Alberto António Caria Canelas Pais; Vitorino, Carla. "CPPs for rerouting nanoparticles in glioblastoma treatment". Paper presented in Coimbra Chemistry Centre Day 2021, Coimbra, Portugal, 2021.
  30. Chierentin, Lucas; Vitorino, Carla. "Design of experiment (DoE) applied in analytical method development". Paper presented in II Congresso de Ciências Aplicadas à Farmácia CONCAF – Online, 2021.
  31. Cova, Tânia F. G. G.; Nunes, Sandra; Vitorino, Carla; Alberto A. C. C. Pais. "Computational modeling of drug recognition by cyclodextrin-based complexes". Paper presented in 14ENQF - 14 Encontro Nacional de Química Física, 2021.
  32. Cláudia Veloso, Catarina Cardoso, Carla Vitorino. "Preclinical development of a fixed-dose combination medicinal product for topical administration – Current in vitro and in vivo methodologies". Paper presented in 3rd SPLC-CRS Young Scientist Virtual Meeting, 2021.
  33. Vitorino, Carla. "A new photoacoustic spectroscopy method for salt assay in solution: paving the way towards a Process Analytical Technology". Paper presented in 3rd SPLC-CRS Young Scientist Virtual Meeting, 2021.
  34. Ana Simões, Francisco Veiga, Carla Vitorino. "Understanding cream formulation: a QbD apporach". Paper presented in 3rd SPLC-CRS Young Scientist Virtual Meeting, 2021.
  35. Vitorino, Carla. "Machine learning for establishing the bridge between formulation design and performance in glioblastoma". Paper presented in 3rd SPLC-CRS Young Scientist Virtual Meeting, 2021.
  36. Simões, Ana; Francisco Veiga; Vitorino, Carla. "Understanding cream formulations: a QbD approach". Paper presented in 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021.
  37. "Understanding cream formulation: a QbD apporach Ana Simões, Francisco Veiga, Carla Vitorino 3rd SPLC-CRS Young Scientist Virtual Meeting, 21 January, 2021". 2021.
  38. "Machine learning for establishing the bridge between formulation design and performance in glioblastoma João Basso, Maria Mendes, Jessica Silva, Tânia Cova, Edurne Luque-Michel, Andreia F. Jorge, Santiago Grijalvo, Lídia Gonçalves, Ramon Eritja, María J. Blanco-Prieto, António José Almeida, Alberto Pais, Carla Vitorino 3rd SPLC-CRS Young Scientist Virtual Meeting, 21 January, 2021". 2021.
  39. "Avoiding contact allergens: from basic research to development of a new medical device Gonçalo Brites, Isabel Ferreira, Ana Silva, Mylène Carrascal, Carla Vitorino, Bruno Neves, Maria Teresa Cruz EUROTOX 2020 Congress – Virtual Congress September 2021". 2021.
  40. "A design of experiments (DoE) applied in analytical method Lucas Chierentin, Catarina Cardoso, Carla Vitorino Anais do II Congresso de Ciências Aplicadas à Farmácia – CONCAF 14 de setembro de 2021". 2021.
  41. "Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach João Basso, Maria Luísa Ramos, Alberto Pais, Rui Vitorino, Ana Fortuna, Carla Vitorino EUPAT 10, Eufeps, Tenth Anniversary pan-European Science Conference on QbD & PAT, Online 4-6 october, 2021". 2021.
  42. "Accelerating Disulfiram Assays using Analytical Quality by Design João Basso, Maria Luísa Ramos, Alberto Pais, Rui Vitorino, Ana Fortuna, Carla Vitorino Coimbra Chemistry Centre Day 2021, Coimbra, Portugal, 15 December, 2021". 2021.
  43. "CPPs for rerouting nanoparticles in glioblastoma treatment Maria Mendes, Lígia Gomes-da-Silva, Luís Arnaut, Nuno Vale, João José Sousa, Alberto Pais, Carla Vitorino Coimbra Chemistry Centre Day 2021, Coimbra, Portugal, 15 December, 2021". 2021.
  44. Basso, João; Mendes, Maria; Silva, Jessica; Cova, Tânia; Alberto, Pais; Vitorino, Carla. "Machine learning for establishing the bridge between formulation design and performance in glioblastoma: do outcomes differ?". Paper presented in RSC Chemical Science Symposium 2020: How can machine learning and autonomy accelerate chemistry?, 2020.
  45. "How can machine learning and autonomy accelerate chemistry? João Basso, Maria Mendes, Jessica Silva, Tânia Cova, Alberto Pais, Carla Vitorino, Chemical Science Symposium 2020: RSC 29-30 setembro, Londres, UK". 2020.
  46. Joana Gonçalves, Soraia Silva, Carla Vitorino, Gilberto Alves, Ana Fortuna.. "How does the device determine nose-to-brain drug delivery to mice?". Paper presented in Drug Delivery to the Lungs 2019, Edinburgh., 2019.
  47. João Basso, Maria Mendes, Jessica Silva, João Sousa, Alberto Pais, Carla Vitorino. "Erythrocyte membrane stealth nanoparticles: a Taguchi optimization study". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal, 2019.
  48. Maria Mendes, João Basso, Jéssica Silva, João Sousa, Santiago Grijalvo, Ramon Eritja, Alberto Pais, Carla Vitorino. "Serinol-based nanostructured lipid nanoparticles for glioblastoma treatment". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal, 2019.
    10.1117/12.931117
  49. João Henriques¿, Fábio Schaberle, Carlos Serpa,Catarina Cardoso¿, Carla Vitorino. "A new photoacoustic method for salt assay in solution". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal, 2019.
  50. Vitorino, Carla. "Batch-to-batch variability of semisolid topical drug products". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal, 2019.
  51. Ana Simões¿, Fancisco Veiga, Carla Vitorino. "Improving cream performance based on a Quality by Design approach". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal, 2019.
  52. Vitorino, Carla. "Erythrocyte membrane-coated nanoparticles: a biomimeting optimization study by experimental design". Paper presented in Okinawa Colloids 2019, Okinawa, Japan, 2019.
  53. Maria Mendes, João Basso, Jéssica Silva, João Sousa, Santiago Grijalvo, Ramon Eritja, Alberto Pais, Carla Vitorino. "Serinol-based nanostructured lipid nanoparticles for glioblastoma treatment". Paper presented in Okinawa Colloids 2019, Okinawa, Japan, 2019.
  54. Margarida Miranda, Alberto Pais, Catarina Cardoso, Carla Vitorino. "Batch-to-batch variability of semisolid topical drug products". Paper presented in Okinawa Colloids 2019, 2019.
  55. Silva, Soraia; Vitorino, Carla; Gonçalves, Joana; Carona, Andreia; Bicker, Joana; Falcão, Amílcar; Fotuna, Ana. "Application of in vitro nasal model for antidepressant drug permeation studies.". Paper presented in 1º Encontro Anual em Ciências Farmacêuticas, 2019.
  56. João Sousa, Jéssica Silva, Maria Mendes, João Basso, Tânia Cova, Alberto Pais, Carla Vitorino. "Unstructured formulation data analysis for the optimization of lipid nanoparticle drug delivery vehicles". Paper presented in 688th International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS), 2019.
  57. Tânia Cova, Carla Vitorino, Sandra Nunes, Alberto Pais, Carla Vitorino. "Modeling of drug recognition by cyclodextrin-based nanostructures: a computational approach". Paper presented in IASTEM - 688th International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS), 2019.
  58. Margarida Miranda, Alberto Pais, Catarina Cardoso, Carla Vitorino. "QbD as a Framework for in vitro Release Testing Development". Paper presented in Formulation 5th Symposium & 17th Skin Forum, Reims, France, 2019.
  59. Ana Simões, Francisco Veiga, Carla Vitorino. "Developing Cream Formulations: Renewed Interest in an Old Problem". Paper presented in Symposium & 17th Skin Forum, Reims, France, 2019.
  60. Vitorino, Carla; Airam Cobo, Daniel Bento, Tânia Cova, Sandra Nunes, Artur Valente, Carla Vitorino, Alberto Pais. "PVA-NLC films for transdermal drug delivery". Paper presented in 8th Iberian Meeting on Colloids and Interfaces, RICI 8, 2019.
  61. Barone, Antonella, Maria Mendes, Celia Cabral, Rosario Mare, Donatella Paolino, Carla Vitorino. "Simvastatin loaded chitosan coated NLC topical films as acoadjuvant treatment of melanoma skin lesions". Paper presented in 3rd European Conference on Pharmaceutics, 2019.
  62. Margarida Miranda, Catarina Cardoso, Carla Vitorino. "Bioequivalence of topical generic products: an evolved concept of pharmaceutical equivalence (P21)". Paper presented in Skin forum 2018 Annual Meeting. Skin health and topical formulation - new insights and perspectives, Tallin, Estonia, 2018.
    10.2969/aspm/07810107
  63. Catarina Camões, M. Matos, F. Silva, L. Sacramento, Carla Vitorino, M. Dourado. "A contribution to the validation of the volume – viscosity swallow test (V-VST) – portuguese version". Paper presented in 4.º Congresso Internacional de Saúde, Instituto Politécnico de Leiria, Portugal, 2018.
  64. Maria Mendes, Sandra Nunes, João Sousa, Alberto Pais, Carla Vitorino. "Expanding Transdermal Delivery with Lipid Nanoparticles: A New Drug-in-NLC-in-Adhesive Design (PC-115, p.171)". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, Coimbra, Portugal, 2018.
  65. Ana Miranda, Tânia Cova, Maria Mendes, João Sousa, Carla Vitorino, Alberto Pais. "Modeling of nanoparticle surface charge for targeting glioblastoma (PC-62, p.118)". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, Coimbra, 2018.
  66. Cova, Tânia Firmino Guerra Guerreiro da; Mendes, Maria; Pais, Alberto A. C. C.; Sousa, João J.; Vitorino, Carla; Miranda, Alexandra. "Modeling of nanoparticle surface charge for targeting glioblastoma". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  67. Maria Mendes, Ana Miranda, Lídia Gonçalves, António Almeida, João Sousa, Eduardo Marques, Alberto Pais, Carla Vitorino. "Serine based gemini lipid nanoparticles for glioblastoma treatment (P59, p.95)". Paper presented in 21st International Symposium on Microencapsulation, Faro, Portugal, 2017.
  68. Margarida Miranda, Manuel E Minas da Piedade, C E S Bernardes, Artur Figueirinha, Carla Vitorino, Célia Cabral. "Development of a NLC hydrogel loaded with ridolfia segetum (l.) Moris essential oil (P63, p.99)". Paper presented in 21st International Symposium on Microencapsulation,, 2017.
  69. Ana Miranda, Tânia Cova, Maria Mendes, João Sousa, Carla Vitorino, Alberto Pais. "Molecular dynamics simulations on glioblastoma: Blood brain barrier mimicry and interactions with chemotherapeutic drugs (P-26)". Paper presented in VII Iberian Meeting on Colloids and Interfaces (RICI7), Madrid, Espanha, 2017.
    10.1364/fio.2016.ff3f.1
  70. Daniel Magano, Bárbara Ramalho, Cátia Ribeiro, Joana Nova, Alberto Pais, Carla Vitorino. "Cationic lipid nanoparticles for topical drug administration (P-24)". Paper presented in VII Iberian Meeting on Colloids and Interfaces (RICI7), Madrid, Espanha, 2017.
  71. Miranda, Alexandra; Cova, Tânia Firmino Guerra Guerreiro da; Mendes, Maria; Vitorino, Carla; Sousa, João J.; Pais, Alberto A. C. C.. "Molecular dynamics simulations on glioblastoma: Blood brain barrier mimicry and interactions with chemotherapeutic drugs". Paper presented in VII Iberian Meeting on Colloids and Interfaces, 2017.
  72. Miranda, Alexandra; Mendes, Maria; Cova, Tânia Firmino Guerra Guerreiro da; Sousa, João J.; Vitorino, Carla; Pais, Alberto A. C. C.. "Serine based gemini lipid nanoparticles for glioblastoma treatment". Paper presented in VII Iberian Meeting on Colloids and Interfaces, 2017.
  73. Márcia Matos, Ana Chambino, Carla Vitorino, Alexandra Vinagre, João Carlos Ramos. "Produtos de branqueamento dentário de venda livre: avaliação de pH". Paper presented in XXXVI Congresso Anual da Sociedade Portuguesa de Estomatologia e Medicina Dentária, 2016.
  74. Maria Mendes, Ana Miranda, Lídia Gonçalves, António Almeida, João Sousa, Eduardo Marques, Alberto Pais, Carla Vitorino. "Serine based gemini lipid nanoparticles for glioblastoma treatment (P-25)". Paper presented in VII Iberian Meeting on Colloids and Interfaces (RICI7), Madrid, Espanha, 2016.
  75. Maria Mendes, Mafalda Vaz, João Sousa, Alberto Pais, Carla Vitorino. "Do lipid nanoparticles modulate gut absorption?". Paper presented in 8th Training School on microencapsulation, Cork, Ireland, 2016.
  76. Maria Mendes, Mafalda Vaz, João Sousa, Alberto Pais, Carla Vitorino. "Tableting of nanostructured lipid carriers for oral drug delivery". Paper presented in III Simpósio de Nanociência e Nanotecnologia Biomédica – Nano2016.pt, Lisboa, 2016.
  77. Maria Truiti, Slavomira Doktorovová, Maria Mendes, Mafalda Vaz, Carla Vitorino, Eliana Souto. "Development of nanostructured lipid carriers (NLC) by factorial design". Paper presented in III Simpósio de Nanociência e Nanotecnologia Biomédica – Nano2016.pt, Lisboa, 2016.
  78. Maria Mendes, João Sousa, Alberto Pais, Carla Vitorino. "Does drug-in-nanoparticles-in-adhesive systems enhance transdermal drug delivery? (P58)". Paper presented in XXIV Encontro Nacional da Sociedade Portuguesa de Química, Coimbra, 2015.
    10.1109/iccme.2007.4381938
  79. Gustavo Costa, João Pinto Ferreira, Carla Vitorino, João José Sousa, Isabel Vitória Figueiredo, Maria Batista. "In vivo topical anti-inflammatory activity of Cymbopogon citratus infusion: flavonoids contribution (GA2014)". Paper presented in 62nd International Congress and Anuual Meeting of the Society for Medicinal Plant and Natural Product Research, 2014.
  80. Carla Vitorino, João Sousa, Isabelle Lamarche, Patrice Gobin, Jean-Christophe Olivier, William Couet, António Almeida, A. "Dual nanostructured lipid carriers for controlled drug delivery (P02, EH4GM-RS6HY-8KW4G-GSZ48-WGCGG)". Paper presented in 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology”, Lisbon, 2014.
  81. Carla Vitorino, Luís Alves, Filipe Antunes, João Sousa, Alberto Pais. "Design of a dual nanostructured lipid carriers formulation based on physicochemical, rheological and mechanical properties (P23, p.167)". Paper presented in 5th Iberian Meeting on Colloids and Interfaces, RICI5, Donostia-San Sebastian, 2013.
  82. Vitorino, Carla. "Lipid nanoparticles as transdermal drug delivery systems: an in vitro-in vivo approach (p.49)". Paper presented in 4th Symposium, Skin & Formulation, Lyon, 2012.
  83. Vitorino, Carla. "Lipid nanoparticles as drug delivery systems (P238, p.123)". Paper presented in 3rd Pharmaceutical Sciences Fair and Exhibition, Pharmaceutical Sciences for the future, Prague, 2011.
  84. Carla Vitorino, João Sousa, António Almeida, Alberto Pais. "Lipid nanoparticles as vehicles for simvastatin delivery – solid lipid nanoparticles versus nanostructured lipid carriers (R6172, p.225)". Paper presented in FIP Pharmaceutical Sciences 2010 World Congress in Association with the AAPS Annual Meeting and Exposition, New Orleans,, 2010.
  85. Vitorino, Carla. "Factorial design – a tool to optimize the composition of solid lipid nanoparticles (P-011, p.102)". Paper presented in XVIII International Conference on Bioencapsulation, 2010.
  86. Vitorino, Carla. "Size modulation of solid lipid nanoparticles in a factorial design framework (3BUEB-2CRBZ-MS7WC-KKWWZ-8ZCZS)". Paper presented in 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology”, Malta, 2010.
Edited book
  1. Nunes, Sandra; Alberto A. C. C. Pais; Cova, Tânia F. G. G.; Vitorino, Carla, ed. Artificial Intelligence for Drug Product Lifecycle Applications. Elsevier. 2024.
    Published
  2. Vitorino, Carla, ed. Nanoparticles for Brain Drug Delivery. Pan Stanford Publishing and CRC Press (Taylor & Francis). 2020.
    Editor
  3. Pais, A.; Sousa, J.J.; Vitorino, C., ed. Simvastatin delivery: Challenges and opportunities. Nova Science Publishers. 2015.
Encyclopedia entry
  1. Mariana Marques Ribeiro; Simões, Marco; Vitorino, Carla; Mascarenhas-Melo Filipa. "Applications of Hydrogels as Wound Dressings". , 2024. https://encyclopedia.pub/entry/56115.
    Published
Journal article
  1. Basso, João; Sereno, José; Matos, Ana Miguel; Oliveira, Rui; Ramos, Maria Luísa; Castelo-Branco, Miguel; Fortuna, Ana; Vitorino, Rui; Vitorino, Carla. "Straight to the core: Intratumoral delivery of pitavastatin and miR-338–5p through lipid nanoparticles inhibits glioblastoma growth". Nano Today 67 (2026): 102954. https://doi.org/10.1016/j.nantod.2025.102954.
    10.1016/j.nantod.2025.102954
  2. S. Marques, Bárbara; Vitorino, Carla; V. Ventura, Fátima. "CRISPR Applications in HIV Management – Prevention, Diagnosis, Monitoring and Treatment". Current HIV/AIDS Reports 23 1 (2026): https://doi.org/10.1007/s11904-025-00769-6.
    10.1007/s11904-025-00769-6
  3. Alexandre Correia; Marta Agostinho Cordeiro; Maria Mendes; Mariana Marques Ribeiro; Filipa Mascarenhas-Melo; Carla Vitorino. "Additive manufacturing of microneedles: a quality by design approach to clinical translation". International Journal of Pharmaceutics (2026): https://doi.org/10.1016/j.ijpharm.2025.126399.
    10.1016/j.ijpharm.2025.126399
  4. Jailson de A. Santos; Steve Catarino; Maria Mendes; Dina Murtinho; Carla Vitorino; Edson C. Silva-Filho; Henrique Girão; Artur J.M. Valente; Edvani C. Muniz. "Engineered poly(vinyl alcohol)-DNA hydrogels for sustained and biocompatible gene delivery". Journal of Drug Delivery Science and Technology (2025): https://doi.org/10.1016/j.jddst.2025.107611.
    10.1016/j.jddst.2025.107611
  5. da Silva, Joana Pinto; Berzosa, Melibea; Chiarentin, Lucas; Delgado-López, Alberto; Almeida, Maria Patrícia; Vitorino, Carla; Figueiras, Ana; et al. "Repurposing bacterial lysates: Engineering inhalable locust bean gum microparticles for respiratory infection prevention". International Journal of Biological Macromolecules 334 (2025): 149097. https://doi.org/10.1016/j.ijbiomac.2025.149097.
    10.1016/j.ijbiomac.2025.149097
  6. Domingues, Cátia; Jarak, Ivana; Coelho, Jorge; Carvalho, Rui A.; Veiga, Francisco; Vitorino, Carla; Dourado, Marília; Figueiras, Ana. "Optimizing Pluronic–PEI Nanocarriers for RNAi Delivery in Oral Cancer: From Polymer Synthesis to Functional Screening". Biomacromolecules 26 11 (2025): 7484-7511. https://doi.org/10.1021/acs.biomac.5c01011.
    10.1021/acs.biomac.5c01011
  7. Jailson A. Santos; Maria Mendes; Dina Murtinho; Carla Vitorino; Edson C. Silva-Filho; Artur J.M. Valente; Edvani C. Muniz. "Biopolymer-enhanced PVA hydrogels for DNA delivery: Structural and functional characterization". Next Materials (2025): https://doi.org/10.1016/j.nxmate.2025.100944.
    10.1016/j.nxmate.2025.100944
  8. Mendes, Maria; Sereno, José; Ramos, Maria Luísa; Fortuna, Ana; Oliveira, Rui; Simões, Susana; Ferreira, Lino; et al. "Dual-targeted hyaluronic acid conjugates on lipid nanoparticles improve delivery and efficacy against glioblastoma: The linkage leads the fate". International Journal of Biological Macromolecules (2025): 148404. https://doi.org/10.1016/j.ijbiomac.2025.148404.
    10.1016/j.ijbiomac.2025.148404
  9. Domingues, Cátia; Jarak, Ivana; Matos, Ana; Veiga, Francisco; Vitorino, Carla; Dourado, Marília; Figueiras, Ana. "Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation". European Journal of Pharmacology 997 (2025): 177466. https://doi.org/10.1016/j.ejphar.2025.177466.
    10.1016/j.ejphar.2025.177466
  10. Lucas Chiarentin; Vera Moura; Alberto A. C. C. Pais; Carla Vitorino. "AQbD Approach Applied to NIR in a Complex Topical Formulation: Bifonazole as Case Study". Pharmaceutics (2025): https://www.mdpi.com/1999-4923/17/7/835.
    10.3390/pharmaceutics17070835
  11. Mendes, Maria; Morais, Ana Sofia; Carlos, Ana; Sousa, João José; Pais, Alberto Canelas; Mihaila, Silvia M.; Vitorino, Carla. "Organ-on-a-chip: Quo vademus? Applications and regulatory status". Colloids and Surfaces B: Biointerfaces 249 (2025): 114507. https://doi.org/10.1016/j.colsurfb.2025.114507.
    10.1016/j.colsurfb.2025.114507
  12. Branco, Francisco; Cunha, Joana; Mendes, Maria; Sousa, João J.; Vitorino, Carla. "3D Bioprinting Models for Glioblastoma: From Scaffold Design to Therapeutic Application". Advanced Materials (2025): https://doi.org/10.1002/adma.202501994.
    10.1002/adma.202501994
  13. Reva, Marina; Mendes, Maria; Sousa, João José; Pais, Alberto; Vitorino, Carla. "boron neutron capture therapy for glioblastoma: The delivery dilemma". Life Sciences 364 (2025): 123435. https://doi.org/10.1016/j.lfs.2025.123435.
    10.1016/j.lfs.2025.123435
  14. Ana Carlos; Maria Mendes; Maria T. Cruz; Alberto Pais; Carla Vitorino. "Ferroptosis driven by nanoparticles for tackling glioblastoma". Cancer Letters (2025): https://doi.org/10.1016/j.canlet.2024.217392.
    10.1016/j.canlet.2024.217392
  15. Chiarentin, Lucas; Moura, Vera; Vitorino, Carla. "Mucoadhesion and rheology characterization in topical semisolid formulations: An AQbD-driven case study". International Journal of Pharmaceutics (2025): 125389. https://doi.org/10.1016/j.ijpharm.2025.125389.
    10.1016/j.ijpharm.2025.125389
  16. João Basso; Ana Fortuna; Rui Vitorino; Carla Vitorino. "Old drugs, new tricks: Delivering pitavastatin-loaded nanostructured lipid carriers for glioblastoma treatment". Colloids and Surfaces B: Biointerfaces (2025): https://doi.org/10.1016/j.colsurfb.2024.114253.
    10.1016/j.colsurfb.2024.114253
  17. Lucas Chiarentin; Vera Moura; Fabio Major; José Catita; Margarida Miranda; Carla Vitorino. "Particle size by design: Standardizing measurements for complex topical drug product assessment". Colloids and Surfaces A: Physicochemical and Engineering Aspects (2025): https://doi.org/10.1016/j.colsurfa.2024.135679.
    10.1016/j.colsurfa.2024.135679
  18. Mendes, Maria; António, Maria; Daniel-da-Silva, Ana L.; Sereno, José; Oliveira, Rui; Arnaut, Luís G.; Gomes, Célia; et al. "A switch-on chemo-photothermal nanotherapy impairs glioblastoma". Materials Horizons (2025): https://doi.org/10.1039/d5mh00351b.
    10.1039/d5mh00351b
  19. João Basso; Ana Miguel Matos; Saeid Ghavami; Ana Fortuna; Rui Vitorino; Carla Vitorino. "Are we better together? Addressing a combined treatment of pitavastatin and temozolomide for brain cancer". European Journal of Pharmacology (2024): https://doi.org/10.1016/j.ejphar.2024.177087.
    10.1016/j.ejphar.2024.177087
  20. Cunha Silva, Leonor; Branco, Francisco; Cunha, Joana; Vitorino, Carla; Gomes, Célia; Carrascal, Mylène A.; Falcão, Amílcar; Miguel Neves, Bruno; Teresa Cruz, Maria. "The potential of exosomes as a new therapeutic strategy for glioblastoma". European Journal of Pharmaceutics and Biopharmaceutics 203 (2024): 114460. https://doi.org/10.1016/j.ejpb.2024.114460.
    10.1016/j.ejpb.2024.114460
  21. Silva, Ana C.Q.; Mendes, Maria; Vitorino, Carla; Montejo, Unai; Alonso-Varona, Ana; Silvestre, Armando J.D.; Vilela, Carla; Freire, Carmen S.R.. "Trilayered nanocellulose-based patches loaded with acyclovir and hyaluronic acid for the treatment of herpetic lesions". International Journal of Biological Macromolecules 277 (2024): 133843. https://doi.org/10.1016/j.ijbiomac.2024.133843.
    10.1016/j.ijbiomac.2024.133843
  22. Lourenço, Diogo; Miranda, Margarida; Sousa, João José; Vitorino, Carla. "Therapeutic-driven framework for bioequivalence assessment of complex topical generic drug products". International Journal of Pharmaceutics 661 (2024): 124398. https://doi.org/10.1016/j.ijpharm.2024.124398.
    10.1016/j.ijpharm.2024.124398
  23. Brites, Gonçalo S.; Ferreira, Isabel; Sebastião, Ana I.; Sousa, Cátia; Silva, Ana; Carrascal, Mylene; Oliveira, Rui C.; et al. "Blocking the adverse outcome pathway of skin sensitization through a N-acetyl cysteine and lysine-loaded hydrogel". Journal of Pharmaceutical Analysis (2024): 101071. https://doi.org/10.1016/j.jpha.2024.101071.
    10.1016/j.jpha.2024.101071
  24. Branco, Francisco; Cunha, Joana; Mendes, Maria; Vitorino, Carla; Sousa, João J.. "Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma". ACS Nano 18 26 (2024): 16359-16394. http://dx.doi.org/10.1021/acsnano.4c01790.
    10.1021/acsnano.4c01790
  25. Figueiredo, Joana; Mendes, Maria; Pais, Alberto; Sousa, João; Vitorino, Carla. "Microfluidics-on-a-chip for designing celecoxib-based amorphous solid dispersions: when the process shapes the product". Drug Delivery and Translational Research (2024): http://dx.doi.org/10.1007/s13346-024-01633-7.
    10.1007/s13346-024-01633-7
  26. Mendes, Maria; Nunes, Sandra; Cova, Tânia; Branco, Francisco; Dyrks, Michael; Koksch, Beate; Vale, Nuno; et al. "Charge-switchable cell-penetrating peptides for rerouting nanoparticles to glioblastoma treatment". Colloids and Surfaces B: Biointerfaces (2024): 113983. http://dx.doi.org/10.1016/j.colsurfb.2024.113983.
    In press • 10.1016/j.colsurfb.2024.113983
  27. Ana Sofia Morais; Maria Mendes; Marta Agostinho Cordeiro; João J. Sousa; Alberto Canelas Pais; Silvia M. Mihaila; Carla Vitorino. "Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16050615.
    10.3390/pharmaceutics16050615
  28. Gomes, Olívia J.S.; Leitão, Anabela; Gaspar, Marisa C.; Vitorino, Carla; Sousa, João J.S.; de Sousa, Hermínio C.; Braga, Mara E.M.; Gando-Ferreira, Licínio M.. "Fortified chocolate mousse with powder and extract from Moringa oleifera leaves for nutritional value improvement". Food Chemistry 441 (2024): 138338. http://dx.doi.org/10.1016/j.foodchem.2023.138338.
    10.1016/j.foodchem.2023.138338
  29. Miranda, Margarida; Volmer, Zoe; Cornick, Alicia; Goody, Aidan; Cardoso, Catarina; Pais, Alberto A.C.C.; Brown, Marc; Vitorino, Carla. "In vitro studies into establishing therapeutic bioequivalence of complex topical products: Weight of evidence". International Journal of Pharmaceutics 656 (2024): 124012. https://doi.org/10.1016/j.ijpharm.2024.124012.
    10.1016/j.ijpharm.2024.124012
  30. Ribeiro, Mariana; Simões, Marco; Vitorino, Carla; Mascarenhas-Melo, Filipa. "Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential". Gels 10 3 (2024): 188. http://dx.doi.org/10.3390/gels10030188.
    10.3390/gels10030188
  31. Cordeiro, Marta Agostinho; Vitorino, Carla; Sinogas, Carlos; Sousa, João J.. "A Regulatory Perspective on Biosimilar Medicines". Pharmaceutics 16 3 (2024): 321. http://dx.doi.org/10.3390/pharmaceutics16030321.
    10.3390/pharmaceutics16030321
  32. Simões, Ana; Veiga, Francisco; Vitorino, Carla. "Question-based review for pharmaceutical development: An enhanced quality approach". European Journal of Pharmaceutics and Biopharmaceutics 195 (2024): 114174. http://dx.doi.org/10.1016/j.ejpb.2023.114174.
    10.1016/j.ejpb.2023.114174
  33. Maria Mendes; Francisco Branco; Rui Vitorino; João Sousa; Alberto Pais; Carla Vitorino. "A two-pronged approach against glioblastoma: drug repurposing and nanoformulation design for in situ-controlled release". Drug Delivery and Translational Research (2023): https://doi.org/10.1007/s13346-023-01379-8.
    10.1007/s13346-023-01379-8
  34. Coimbra, Patrícia; Marona, Beatriz; Henriques, Marta H.F.; Campos, Lara; Gomes, David M.G.S.; Vitorino, Carla; Sousa, João J.S.; Braga, Mara E.M.; Gaspar, Marisa C.. "Edible films based on potato and quince peels with potential for the preservation of cured cheese". Food Packaging and Shelf Life 40 (2023): 101176. http://dx.doi.org/10.1016/j.fpsl.2023.101176.
    10.1016/j.fpsl.2023.101176
  35. Ana Simões; Ricardo A.E. Castro; Francisco Veiga; Carla Vitorino. "A quality by design framework for developing nanocrystal bioenabling formulations". International Journal of Pharmaceutics (2023): https://doi.org/10.1016/j.ijpharm.2023.123393.
    10.1016/j.ijpharm.2023.123393
  36. Chiarentin, Lucas; Gonçalves, Carla; Augusto, Cátia; Miranda, Margarida; Cardoso, Catarina; Vitorino, Carla. "Drilling into “Quality by Design” Approach for Analytical Methods". Critical Reviews in Analytical Chemistry (2023): 1-42. http://dx.doi.org/10.1080/10408347.2023.2253321.
    10.1080/10408347.2023.2253321
  37. Henriques, Patrícia; Bicker, Joana; Carona, Andreia; Miranda, Margarida; Vitorino, Carla; Doktorovová, Slavomíra; Fortuna, Ana. "Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics". Journal of Pharmaceutical Investigation 53 5 (2023): 723-742. http://dx.doi.org/10.1007/s40005-023-00630-1.
    10.1007/s40005-023-00630-1
  38. Sena, Ariana; Costa, Alain; Bastos, Francisca; Pinto, Ana Catarina; Vitorino, Carla; Nunes, António; Simões, Sérgio. "Development of a buccal in vitro permeation method – exploring aQbD implementation". International Journal of Pharmaceutics 643 (2023): 123255. http://dx.doi.org/10.1016/j.ijpharm.2023.123255.
    10.1016/j.ijpharm.2023.123255
  39. Chiarentin, Lucas; Cardoso, Catarina; Miranda, Margarida; Vitorino, Carla. "Rheology of Complex Topical Formulations: An Analytical Quality by Design Approach to Method Optimization and Validation". Pharmaceutics 15 7 (2023): 1810. http://dx.doi.org/10.3390/pharmaceutics15071810.
    10.3390/pharmaceutics15071810
  40. Barzegar Behrooz, Amir; Latifi-Navid, Hamid; da Silva Rosa, Simone C.; Swiat, Maciej; Wiechec, Emilia; Vitorino, Carla; Vitorino, Rui; Jamalpoor, Zahra; Ghavami, Saeid. "Integrating Multi-Omics Analysis for Enhanced Diagnosis and Treatment of Glioblastoma: A Comprehensive Data-Driven Approach". Cancers 15 12 (2023): 3158. http://dx.doi.org/10.3390/cancers15123158.
    10.3390/cancers15123158
  41. Miranda, Margarida; Cardoso, Catarina; Pais, Alberto A.C.C.; Brown, Marc; Vitorino, Carla. "Drilling down the bioequivalence assessment of topical antifungal products: Microstructure and release". European Journal of Pharmaceutics and Biopharmaceutics 185 (2023): 94-106. https://doi.org/10.1016/j.ejpb.2023.02.006.
    10.1016/j.ejpb.2023.02.006
  42. Pedro, Sónia N.; Gomes, Ana T. P. C.; Vilela, Carla; Vitorino, Carla; Fernandes, Rosa; Almeida, Adelaide; Amaral, Maria Helena; et al. "Thermo-Responsive Microemulsions Containing Deep Eutectic-Based Antibiotic Formulations for Improved Treatment of Resistant Bacterial Ocular Infections". Advanced Therapeutics (2023): 2200235. http://dx.doi.org/10.1002/adtp.202200235.
    10.1002/adtp.202200235
  43. Maria Mendes; João Sousa; Alberto Pais; Carla Vitorino. "Can Celecoxib Assay in Preclinical Studies Be Improved?". Processes (2023): https://doi.org/10.3390/pr11020431.
    10.3390/pr11020431
  44. Ferreira, Nuno R.; Vitorino, Carla; Fortuna, Ana. "From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder". Biochemical Pharmacology 206 (2022): 115300. http://dx.doi.org/10.1016/j.bcp.2022.115300.
    10.1016/j.bcp.2022.115300
  45. Mónica Zuzarte; Carla Vitorino; Lígia Salgueiro; Henrique Girão. "Plant Nanovesicles for Essential Oil Delivery". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14122581.
    10.3390/pharmaceutics14122581
  46. Brites, Gonçalo; Basso, João; Miranda, Margarida; Miguel Neves, Bruno; Vitorino, Carla; Cruz, Maria T.. "Development of a new hydrogel for the prevention of allergic contact dermatitis". International Journal of Pharmaceutics 628 (2022): 122265. http://dx.doi.org/10.1016/j.ijpharm.2022.122265.
    10.1016/j.ijpharm.2022.122265
  47. Veloso, Cláudia; Videira, Romeu A.; Andrade, Paula B.; Cardoso, Catarina; Vitorino, Carla. "In vivo methodologies to assist preclinical development of topical fixed-dose combinations for pain management". International Journal of Pharmaceutics 616 (2022): 121530. http://dx.doi.org/10.1016/j.ijpharm.2022.121530.
    10.1016/j.ijpharm.2022.121530
  48. Miranda, Margarida; Veloso, Cláudia; Brown, Marc; A. C. C. Pais, Alberto; Cardoso, Catarina; Vitorino, Carla. "Topical bioequivalence: Experimental and regulatory considerations following formulation complexity". International Journal of Pharmaceutics (2022): 121705. http://dx.doi.org/10.1016/j.ijpharm.2022.121705.
    10.1016/j.ijpharm.2022.121705
  49. Luís Alves; Ana Ramos; Maria G. Rasteiro; Carla Vitorino; Eduardo Ferraz; Paulo J. T. Ferreira; Maria L. Puertas; José A. F. Gamelas. "Composite Films of Nanofibrillated Cellulose with Sepiolite: Effect of Preparation Strategy". Coatings 12 3 (2022): 303-303. https://doi.org/10.3390/coatings12030303.
    10.3390/coatings12030303
  50. João Basso; Marco G. Paggi; Ana Fortuna; Carla Vitorino; Rui Vitorino. "Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma". Molecular Genetics and Genomics (2022): https://doi.org/10.1007/s00438-022-01866-6.
    10.1007/s00438-022-01866-6
  51. Veloso, Cláudia; Videira, Romeu A; Andrade, Paula B.; Cardoso, Catarina; Vitorino, Carla. "Topical Fixed-Dose Combinations: Current in vitro methodologies for pre-clinical development". International Journal of Pharmaceutics (2022): 121621. http://dx.doi.org/10.1016/j.ijpharm.2022.121621.
    Published • 10.1016/j.ijpharm.2022.121621
  52. João Basso; Maria Mendes; Tânia Cova; João Sousa; Alberto Pais; Ana Fortuna; Rui Vitorino; Carla Vitorino. "A Stepwise Framework for the Systematic Development of Lipid Nanoparticles". Biomolecules (2022): https://doi.org/10.3390/biom12020223.
    10.3390/biom12020223
  53. Silva, Soraia; Bicker, Joana; Fonseca, Carla; Ferreira, Nuno R.; Vitorino, Carla; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation". Frontiers in Pharmacology 12 (2021): http://dx.doi.org/10.3389/fphar.2021.751321.
    10.3389/fphar.2021.751321
  54. Cláudia Veloso; Catarina Cardoso; Carla Vitorino. "Topical Fixed-Dose Combinations: A Way of Progress for Pain Management?". Journal of Pharmaceutical Sciences 110 10 (2021): 3345-3361. https://doi.org/10.1016/j.xphs.2021.06.009.
    10.1016/j.xphs.2021.06.009
  55. Airam Cobo Solís; Daniel Bento; Sandra Nunes; Artur Valente; Alberto Pais; Carla Vitorino. "Rethinking transdermal drug delivery using PVA-NLC based films". Polymer 230 (2021): 124032-124032. https://doi.org/10.1016/j.polymer.2021.124032.
    10.1016/j.polymer.2021.124032
  56. João Basso; Maria Luísa Ramos; Alberto Pais; Rui Vitorino; Ana Fortuna; Carla Vitorino. "Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach". Chemosensors 9 7 (2021): 172-172. https://doi.org/10.3390/chemosensors9070172.
    10.3390/chemosensors9070172
  57. Natacha Coelho; Alexandra Filipe; Bruno Medronho; Solange Magalhães; Carla Vitorino; Luís Alves; Sandra Gonçalves; Anabela Romano. "Rheological and Microstructural Features of Plant Culture Media Doped with Biopolymers: Influence on the Growth and Physiological Responses of In Vitro-Grown Shoots of Thymus lotocephalus". Polysaccharides (2021): https://doi.org/10.3390/polysaccharides2020032.
    10.3390/polysaccharides2020032
  58. Fábio Trindade; António S. Barros; Jéssica Silva; Antonia Vlahou; Inês Falcão-Pires; Sofia Guedes; Carla Vitorino; et al. "Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases". International Journal of Molecular Sciences 22 11 (2021): 5940-5940. https://doi.org/10.3390/ijms22115940.
    10.3390/ijms22115940
  59. Vieira, Isa; Sousa, João José; Vitorino, Carla. "Paediatric Medicines – Regulatory Drivers, Restraints, Opportunities and Challenges". Journal of Pharmaceutical Sciences 110 4 (2021): 1545-1556. http://dx.doi.org/10.1016/j.xphs.2020.12.036.
    10.1016/j.xphs.2020.12.036
  60. Solange Magalhães; Alexandra Filipe; Elodie Melro; Catarina Fernandes; Carla Vitorino; Luís Alves; Anabela Romano; Maria G. Rasteiro; Bruno Medronho. "Lignin Extraction from Waste Pine Sawdust Using a Biomass Derived Binary Solvent System". Polymers (2021): https://doi.org/10.3390/polym13071090.
    10.3390/polym13071090
  61. Basso, João; Mendes, Maria; Silva, Jessica; Cova, Tânia; Luque-Michel, Edurne; Jorge, Andreia F.; Grijalvo, Santiago; et al. "Sorting hidden patterns in nanoparticle performance for glioblastoma using machine learning algorithms". International Journal of Pharmaceutics (2020): 120095. http://dx.doi.org/10.1016/j.ijpharm.2020.120095.
    10.1016/j.ijpharm.2020.120095
  62. Miranda, Margarida; Cova, Tânia; Augusto, Cátia; Pais, Alberto A. C. C.; Cardoso, Catarina; Vitorino, Carla. "Diving into Batch-to-Batch Variability of Topical Products-a Regulatory Bottleneck". Pharmaceutical Research 37 11 (2020): http://dx.doi.org/10.1007/s11095-020-02911-y.
    10.1007/s11095-020-02911-y
  63. Vitorino, Rui; Guedes, Sofia; Vitorino, Carla; Ferreira, Rita; Amado, Francisco; Van Eyk, Jennifer E.. "Elucidating Citrullination by Mass Spectrometry and its role in Disease Pathogenesis". Journal of Proteome Research (2020): http://dx.doi.org/10.1021/acs.jproteome.0c00474.
    10.1021/acs.jproteome.0c00474
  64. Ana Simões; Margarida Miranda; Catarina Cardoso; Francisco Veiga; Carla Vitorino. "Rheology by Design: A Regulatory Tutorial for Analytical Method Validation". Pharmaceutics 12 9 (2020): 820-820. https://doi.org/10.3390/pharmaceutics12090820.
    10.3390/pharmaceutics12090820
  65. Basso, João; Mendes, Maria; Silva, Jessica; Sereno, José; Cova, Tânia; Oliveira, Rui; Fortuna, Ana; et al. "Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment". European Journal of Pharmaceutics and Biopharmaceutics (2020): http://dx.doi.org/10.1016/j.ejpb.2020.08.015.
    In press • 10.1016/j.ejpb.2020.08.015
  66. Henriques, João; Schaberle, Fábio A.; Serpa, Carlos; Pais, Alberto A.C.C.; Cardoso, Catarina; Vitorino, Carla. "Photoacoustic method for real-time assessment of salt content in aqueous solutions". Talanta (2020): 121497. http://dx.doi.org/10.1016/j.talanta.2020.121497.
    In press • 10.1016/j.talanta.2020.121497
  67. Vitorino, Carla; Silva, Soraia; Gouveia, Filipa; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "QbD-driven development of intranasal lipid nanoparticles for depression treatment". European Journal of Pharmaceutics and Biopharmaceutics 153 (2020): 106-120. http://dx.doi.org/10.1016/j.ejpb.2020.04.011.
    10.1016/j.ejpb.2020.04.011
  68. Simões, Ana; Veiga, Francisco; Vitorino, Carla. "Progressing Towards the Sustainable Development of Cream Formulations". Pharmaceutics 12 7 (2020): 647. http://dx.doi.org/10.3390/pharmaceutics12070647.
    10.3390/pharmaceutics12070647
  69. Mendes, Maria; Cova, Tânia; Basso, João; Ramos, M. Luísa; Vitorino, Rui; Sousa, João; Pais, Alberto; Vitorino, Carla. "Hierarchical design of hyaluronic acid-peptide constructs for glioblastoma targeting: Combining insights from NMR and molecular dynamics simulations". Journal of Molecular Liquids (2020): 113774. http://dx.doi.org/10.1016/j.molliq.2020.113774.
    10.1016/j.molliq.2020.113774
  70. Mendes, Maria; Basso, João; Silva, Jessica; Cova, Tânia; Sousa, João; Pais, Alberto; Vitorino, Carla. "Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: a computationally guided experimental approach". International Journal of Pharmaceutics (2020): 119661. http://dx.doi.org/10.1016/j.ijpharm.2020.119661.
    10.1016/j.ijpharm.2020.119661
  71. Miranda, Margarida; Cardoso, Catarina; Vitorino, Carla. "Fast Screening Methods for the Analysis of Topical Drug Products". Processes 8 4 (2020): 397. http://dx.doi.org/10.3390/pr8040397.
    10.3390/pr8040397
  72. Gonçalves, Joana; Alves, Gilberto; Carona, Andreia; Bicker, Joana; Vitorino, Carla; Falcão, Amílcar; Fortuna, Ana. "Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration". Pharmaceutical Research 37 4 (2020): http://dx.doi.org/10.1007/s11095-020-02786-z.
    10.1007/s11095-020-02786-z
  73. Ferreira, Maria; Sousa, João; Pais, Alberto; Vitorino, Carla. "The Role of Magnetic Nanoparticles in Cancer Nanotheranostics". Materials 13 2 (2020): 266. http://dx.doi.org/10.3390/ma13020266.
    10.3390/ma13020266
  74. Mafalda. B. Vaz; Carla Vitorino; João J. S. Sousa. "Safe-by-design development of a topical patch for drug delivery". Brazilian Journal of Pharmaceutical Sciences (2020): https://doi.org/10.1590/s2175-97902020000118629.
    10.1590/s2175-97902020000118629
  75. Miranda, Margarida; Pais, Alberto A.C.C.; Cardoso, Catarina; Vitorino, Carla. "aQbD as a platform for IVRT method development – A regulatory oriented approach". International Journal of Pharmaceutics 572 (2019): 118695. http://dx.doi.org/10.1016/j.ijpharm.2019.118695.
    10.1016/j.ijpharm.2019.118695
  76. Margarida Miranda; Catarina Cardoso; Carla Vitorino. "Quality and Equivalence of Topical Products: A Critical Appraisal". European Journal of Pharmaceutical Sciences (2019): https://doi.org/10.1016/j.ejps.2019.105082.
    10.1016/j.ejps.2019.105082
  77. Jessica Silva; João Basso; João Sousa; Ana Fortuna; Carla Vitorino. "Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice". Biomedical Chromatography (2019): e4621-e4621. https://doi.org/10.1002/bmc.4621.
    10.1002/bmc.4621
  78. João Henriques; João Sousa; Francisco Veiga; Catarina Cardoso; Carla Vitorino. "Process analytical technologies and injectable drug products: Is there a future?". International Journal of Pharmaceutics 554 (2019): 21-35. https://doi.org/10.1016/j.ijpharm.2018.10.070.
    10.1016/j.ijpharm.2018.10.070
  79. Ana, Raquel; Mendes, Maria; Sousa, João; Pais, Alberto; Falcão, Amílcar; Fortuna, Ana; Vitorino, Carla; et al. "Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles". International Journal of Pharmaceutics 554 (2019): 352-365. http://dx.doi.org/10.1016/j.ijpharm.2018.11.028.
    10.1016/j.ijpharm.2018.11.028
  80. Miranda, M.; Cruz, M.T.; Vitorino, C.; Cabral, C.. "Nanostructuring lipid carriers using Ridolfia segetum (L.) Moris essential oil". Materials Science and Engineering C 103 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066465144&partnerID=MN8TOARS.
    10.1016/j.msec.2019.109804
  81. Simões, A.; Veiga, F.; Vitorino, C.. "Developing Cream Formulations: Renewed Interest in an Old Problem". Journal of Pharmaceutical Sciences (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068520861&partnerID=MN8TOARS.
    10.1016/j.xphs.2019.06.006
  82. Henriques, J.; Cardoso, C.; Vitorino, C.. "On demand for new process analytical technologies applied to injectable drug products". European Journal of Pharmaceutical Sciences 137 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068237992&partnerID=MN8TOARS.
    10.1016/j.ejps.2019.104975
  83. Barone, A.; Mendes, M.; Cabral, C.; Mare, R.; Paolino, D.; Vitorino, C.. "Hybrid Nanostructured Films for Topical Administration of Simvastatin as Coadjuvant Treatment of Melanoma". Journal of Pharmaceutical Sciences (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068477376&partnerID=MN8TOARS.
    10.1016/j.xphs.2019.06.002
  84. Vitorino, C.; Silva, S.; Bicker, J.; Falcão, A.; Fortuna, A.; Carla Vitorino, Soraia Silva, Joana Bicker, Amílcar Falcao, Ana Fortuna. "Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges". Drug Discovery Today (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067172382&partnerID=MN8TOARS.
    Accepted • 10.1016/j.drudis.2019.06.001
  85. Mendes, Maria; Sousa, João José; Pais, Alberto; Vitorino, Carla. "Targeted Theranostic Nanoparticles for Brain Tumor Treatment". Pharmaceutics 10 4 (2018): 181. http://dx.doi.org/10.3390/pharmaceutics10040181.
    Published • 10.3390/pharmaceutics10040181
  86. Margarida Miranda; João José Sousa; Francisco Veiga; Catarina Cardoso; Carla Vitorino. "Bioequivalence of topical generic products. Part 1: Where are we now?". European Journal of Pharmaceutical Sciences 123 (2018): 260-267. https://doi.org/10.1016/j.ejps.2018.07.050.
    10.1016/j.ejps.2018.07.050
  87. Simões, Ana; Veiga, Francisco; Vitorino, Carla; Figueiras, Ana. "A Tutorial for Developing a Topical Cream Formulation Based on the Quality by Design Approach". Journal of Pharmaceutical Sciences 107 10 (2018): 2653-2662. http://dx.doi.org/10.1016/j.xphs.2018.06.010.
    10.1016/j.xphs.2018.06.010
  88. Ana Simões; Francisco Veiga; Ana Figueiras; Carla Vitorino. "A practical framework for implementing Quality by Design to the development of topical drug products: Nanosystem-based dosage forms". International Journal of Pharmaceutics 548 1 (2018): 385-399. https://doi.org/10.1016/j.ijpharm.2018.06.052.
    10.1016/j.ijpharm.2018.06.052
  89. Miranda, Margarida; Sousa, João José; Veiga, Francisco; Cardoso, Catarina; Vitorino, Carla; Margarida Miranda; João José Sousa; et al. "Bioequivalence of topical generic products. Part 2. Paving the way to a tailored regulatory system". European Journal of Pharmaceutical Sciences 122 (2018): 264-272. http://dx.doi.org/10.1016/j.ejps.2018.07.011.
    10.1016/j.ejps.2018.07.011
  90. Soares, Sara; Sousa, João; Pais, Alberto; Vitorino, Carla. "Nanomedicine: Principles, Properties, and Regulatory Issues". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00360.
    10.3389/fchem.2018.00360
  91. João Basso; Ana Miranda; João Sousa; Alberto Pais; Carla Vitorino. "Repurposing drugs for glioblastoma: From bench to bedside". Cancer Letters 428 (2018): 173-183. https://doi.org/10.1016/j.canlet.2018.04.039.
    10.1016/j.canlet.2018.04.039
  92. Basso, João; Miranda, Ana; Nunes, Sandra; Cova, Tânia; Sousa, João; Vitorino, Carla; Pais, Alberto. "Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors". Gels 4 3 (2018): 62. http://dx.doi.org/10.3390/gels4030062.
    10.3390/gels4030062
  93. Silva, Jessica; Mendes, Maria; Cova, Tânia; Sousa, João; Pais, Alberto; Vitorino, Carla. "Unstructured Formulation Data Analysis for the Optimization of Lipid Nanoparticle Drug Delivery Vehicles". AAPS PharmSciTech 19 5 (2018): 2383-2394. http://dx.doi.org/10.1208/s12249-018-1078-0.
    10.1208/s12249-018-1078-0
  94. Mendes, Maria; Miranda, Ana; Cova, Tânia; Gonçalves, Lídia; Almeida, António J.; Sousa, João J.; do Vale, Maria L.C.; et al. "Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma". European Journal of Pharmaceutical Sciences 117 (2018): 255-269. http://dx.doi.org/10.1016/j.ejps.2018.02.024.
    10.1016/j.ejps.2018.02.024
  95. Basso, João; Miranda, Ana; Nunes, Sandra; Cova, Tânia F.G.G.; Sousa, João; Vitorino, Carla; Pais, A.A.C.C.. "Cover". Gels 4 3 (2018): http://dx.doi.org/10.14714/cp83.1385.
    Published • 10.14714/cp83.1385
  96. Miranda, Ana; Cova, Tânia; Sousa, João; Vitorino, Carla; Pais, Alberto. "Computational modeling in glioblastoma: from the prediction of blood–brain barrier permeability to the simulation of tumor behavior". Future Medicinal Chemistry 10 1 (2018): 121-131. http://dx.doi.org/10.4155/fmc-2017-0128.
    10.4155/fmc-2017-0128
  97. Basso, João; Mendes, Maria; Cova, Tânia F. G. G.; Sousa, João J.; Pais, Alberto A. C. C.; Vitorino, Carla; João Basso; et al. "Analytical Quality by Design (AQbD) as a multiaddressable platform for co-encapsulating drug assays". Analytical Methods 10 47 (2018): 5659-5671. http://dx.doi.org/10.1039/c8ay01695j.
    10.1039/c8ay01695j
  98. Ana Miranda; María J Blanco-Prieto; João Sousa; Alberto Pais; Carla Vitorino. "Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles". International Journal of Pharmaceutics 531 1 (2017): 389-410. https://doi.org/10.1016%2Fj.ijpharm.2017.07.049.
    10.1016/j.ijpharm.2017.07.049
  99. Ana Miranda; María Blanco-Prieto; João Sousa; Alberto Pais; Carla Vitorino. "Breaching barriers in glioblastoma. Part I: Molecular pathways and novel treatment approaches". International Journal of Pharmaceutics 531 1 (2017): 372-388. https://doi.org/10.1016%2Fj.ijpharm.2017.07.056.
    10.1016/j.ijpharm.2017.07.056
  100. M. Mendes; S. C. C. Nunes; J. J. Sousa; A. A. C. C. Pais; C. Vitorino. "Expanding Transdermal Delivery with Lipid Nanoparticles: A New Drug-in-NLC-in-Adhesive Design". Molecular Pharmaceutics 14 6 (2017): 2099-2115. https://doi.org/10.1021/acs.molpharmaceut.7b00211.
    10.1021/acs.molpharmaceut.7b00211
  101. M. Mendes; H.T Soares; L.G Arnaut; J.J Sousa; A.A.C.C. Pais; C. Vitorino. "Can lipid nanoparticles improve intestinal absorption?". International Journal of Pharmaceutics 515 1-2 (2016): 69-83. https://doi.org/10.1016/j.ijpharm.2016.09.065.
    10.1016/j.ijpharm.2016.09.065
  102. Iqbal, Nimra; Vitorino, Carla; Taylor, Kevin M. G.. "How can lipid nanocarriers improve transdermal delivery of olanzapine?". Pharmaceutical Development and Technology 22 4 (2016): 587-596. http://dx.doi.org/10.1080/10837450.2016.1200615.
    10.1080/10837450.2016.1200615
  103. Costa, G.; Ferreira, J.P.; Vitorino, C.; Pina, M.E.; Sousa, J.J.; Figueiredo, I.V.; Batista, M.T.. "Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents". Journal of Ethnopharmacology 178 (2016): 222-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951202476&partnerID=MN8TOARS.
    10.1016/j.jep.2015.12.016
  104. Baptista, J.G.C.; Rodrigues, S.P.J.; Matsushita, A.F.Y.; Vitorino, C.; Maria, T.M.R.; Burrows, H.D.; Pais, A.A.C.C.; Valente, A.J.M.. "Does poly(vinyl alcohol) act as an amphiphilic polymer? An interaction study with simvastatin". Journal of Molecular Liquids 222 (2016): 287-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978705114&partnerID=MN8TOARS.
    10.1016/j.molliq.2016.07.025
  105. Vitorino, C.; Sousa, J.; Pais, A.. "Overcoming the skin permeation barrier: Challenges and opportunities". Current Pharmaceutical Design 21 20 (2015): 2698-2712. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930883529&partnerID=MN8TOARS.
  106. Costa, G.; Nunes, F.; Vitorino, C.; Sousa, J.J.; Figueiredo, I.V.; Batista, M.T.. "Validation of a RP-HPLC method for quantitation of phenolic compounds in three different extracts from Cymbopogon citratus". Research Journal of Medicinal Plant 9 7 (2015): 331-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941630148&partnerID=MN8TOARS.
    10.3923/rjmp.2015.331.339
  107. Soares, M.; Vitorino, C.; Sousa, J.; Pais, A.. "Skin permeation: Challenges and opportunities,Permeação cutânea: Desafios e oportunidades". Revista de Ciencias Farmaceuticas Basica e Aplicada 36 3 (2015): 337-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003434336&partnerID=MN8TOARS.
  108. Vitorino, C.; Almeida, A.; Sousa, J.; Lamarche, I.; Gobin, P.; Marchand, S.; Couet, W.; Olivier, J.-C.; Pais, A.. "Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies". European Journal of Pharmaceutics and Biopharmaceutics 86 2 (2014): 133-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896389539&partnerID=MN8TOARS.
    10.1016/j.ejpb.2013.12.004
  109. Vitorino, C.; Alves, L.; Antunes, F.E.; Sousa, J.J.; Pais, A.A.C.C.. "Design of a dual nanostructured lipid carrier formulation based on physicochemical, rheological, and mechanical properties". Journal of Nanoparticle Research 15 10 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84887009174&partnerID=MN8TOARS.
    10.1007/s11051-013-1993-7
  110. Vitorino, C.; Sousa, J.J.; Pais, A.A.C.C.. "A rapid reversed-phase HPLC method for the simultaneous analysis of olanzapine and simvastatin in dual nanostructured lipid carriers". Analytical Methods 5 19 (2013): 5058-5064. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884176105&partnerID=MN8TOARS.
    10.1039/c3ay40757h
  111. Vitorino, C.; Almeida, J.; Gonçalves, L.M.; Almeida, A.J.; Sousa, J.J.; Pais, A.A.C.C.. "Co-encapsulating nanostructured lipid carriers for transdermal application: From experimental design to the molecular detail". Journal of Controlled Release 167 3 (2013): 301-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874943703&partnerID=MN8TOARS.
    10.1016/j.jconrel.2013.02.011
  112. Vitorino, C.; Carvalho, F.A.; Almeida, A.J.; Sousa, J.J.; Pais, A.A.C.C.. "The size of solid lipid nanoparticles: An interpretation from experimental design". Colloids and Surfaces B: Biointerfaces 84 1 (2011): 117-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951683338&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2010.12.024
Journal issue
  1. Vitorino, Carla. "The Role of Nanoparticles in Tumor Treatment". Biomolecules (2025): https://www.mdpi.com/journal/biomolecules/special_issues/R67E3H7054..
  2. Carla Vitorino, João Basso, Ana Fortuna and Rui Vitorino. "Findings, Insights and Perspectives on Central Nervous System Tumors, Special Issue of the Journals Cancers, Cells, Diseases, Nanomaterials, Pharmaceutics, 2024 https://www.mdpi.com/topics/376L607G1U". (2024):
  3. Nunes, Sandra; Cova, Tânia F. G. G.; Vitorino, Carla. "Advances in Molecular Dynamics Simulation of Chemical and Biomedical Systems". International Journal of Molecular Sciences (2024): https://www.mdpi.com/journal/ijms/special_issues/112CJGFEV2.
  4. Carla Vitorino, Marlene Lúcio and Carla M. Lopes, 2023. "Nanotechnology in Drug Delivery, Special Issue of Biomolecules, https://www.mdpi.com/journal/biomolecules/special_issues/2U4711IU4S.". (2023):
  5. "Advanced Pharmaceutical Science and Technology in Portugal, Special Issue of Biomolecules, 2021, Carla Vitorino, Alberto Pais, João José Sousa (ongoing). https://www.mdpi.com/journal/pharmaceutics/special_issues/Pharm_Portugal". (2022):
  6. ""Applications of Nanoparticles in Tumor Therapy", Special Issue of Biomolecules, 2021, Carla Vitorino, Maria Virtudes Céspedes (ongoing). https://www.mdpi.com/journal/biomolecules/special_issues/applications_nanoparticles". (2021):
  7. Vitorino, Carla. "Development and Characterization of Nanocarriers for Drugs". Processes (2020):
  8. Vitorino, Carla. "Pharmaceutical development and regulatory aspects of drug products for skin delivery: what is new?". (2020):
  9. Carla Vitorino, João Sousa e Alberto Pais. "Nanotheranostics and Cancer: Where Are We Now?". Pharmaceutics (2018): https://www.mdpi.com/journal/pharmaceutics/special_issues/Nano_Theranostics_Cancer.
    Published • Editor
Magazine article
  1. Carla Vitorino, João José Sousa, Francisco Veiga. "Impacto del dossier Técnico Común – CTD para el registro de medicamentos", FARMA & COSMETICA , 2016, http://www.revistafarmaycosmetica.com/farma-cosmetica-n2/.
Manual
  1. Vitorino, Carla. Manual Laboratorial de Farmácia Galénica, Faculty of Pharmacy, University of Coimbra. Coimbra, Portugal. 2014.
    Published
Newsletter article
  1. Vitorino, Carla. "Nanopartículas lipídicas no transporte de fármacos para administração transdérmica Carla Vitorino, 2010", 2010, http://www.uc.pt/noticias/01_NL_2011/nuc01_012011/.
Online resource
  1. Miranda, Ana; Basso, João; Cova, Tânia F.; Nunes, Sandra C. C.; Sousa, João J.; Pais, Alberto A. C. C.; Vitorino, Carla. Outside Front Cover, Gels, Volume 4, Issue 3 (September 2018). 2018. https://www.mdpi.com/2310-2861/4/3?view=abstract&listby=date&page_no=1.
Preface / Postscript
  1. Vitorino, Carla; Sousa, JJ; A.J. Almeida; Miranda, M. "Forward". Preface to Time-Proof Perspectives on Bioequivalence. Nova Science publishers. 2023.
    Published
  2. Pais, A.; Sousa, J.J.; Vitorino, C.. "Preface". 2015.

Intellectual property

Patent
  1. Maria Cruz, Gonçalo Brites, Isabel do Vale, Ana Silva, Carla Vitorino, Margarida Gonçalo, Bruno Neves. 2023. "Topical composition and uses thereof".
    Pending
  2. Ana Fortuna, Amílcar Falcão, Carla Vitorino, Joana Bicker, Tânia Silva, Carla Fonseca. 2022. "INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS".
    Expired
  3. Maria Mendes, João Sousa, Alberto Pais, José Sereno, Miguel Castelo Branco, Maria António, Ana Silva, Carla Vitorino. 2022. "HYBRID NANOPARTICLES AS MULTIFUNCTIONAL PLATFORM FOR BRAIN TUMOR THERAPY".
    Pending
  4. Vitorino, Carla; Fortuna, Ana. 2020. "PCT/IB2020/061452 - WO/2021/111364A1 : Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy".
Provisional application for patent
  1. 2026. "Temozolomide-derivative for brain tumor therapy".
  2. 2025. "Method and apparatus for characterisation of a fluid sample by ultrasonic signals".
  3. 2025. "SkinGuard53-VITD: an innovative topical formulation to knockout skin cancer".

Other

Other output
  1. COVER: Old drugs, new tricks: Delivering pitavastatin-loaded nanostructured lipid carriers for glioblastoma treatment. 2025. João Basso, Ana Fortuna, Rui Vitorino, Carla Vitorino.
  2. COVER: Charge-switchable cell-penetrating peptides for rerouting nanoparticles to glioblastoma treatment, Cover of Colloids and Surfaces B: Biointerfaces, 2024, 241, 113983, ISNN 0927-7765. 2024. Maria Mendes, Sandra Nunes, Tânia Cova, Francisco Branco, Michael Dyrks, Beate Koksch, Nuno Vale, Alberto Pais, João Sou.
  3. Participação na rubrica do Diário das Beiras - "Investigando na UC" - Nanopartículas lipídicas sólidas para o tratamento de tumores cerebrais. 2022.
  4. COVER: Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors, Cover of Issue 3, Volume 4 in /Gels/., http://www.mdpi.com/2310-2861/4/3, 2018. 2018. João Basso, Ana Miranda, Sandra Nunes, Tânia Cova, João Sousa, Carla Vitorino*, Alberto Pais.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022 Preventing allergic contact dermatitis: in vivo proof-of-concept using the local lymph node assay Gonçalo Brites, João Basso, Margarida Miranda,Isabel Ferreira, Ana Silva, Carla Vitorino, Bruno Neves, Maria Teresa Cruz SPF2022, 9-11 de fevereiro 2022, Porto, Portugal
2021/10/21 Solid lipid nanoparticles for transdermal drug delivery: where are we? 1st Symposium on Advanced Technologies for Drug Delivery
Faculdade de Farmácia, Universidade de Lisboa
2021/09/03 Nanotechnological approaches in cancer: repurposing drugs Nanoparticles for drug repurposing in oncology and COVID-19 course
Faculdade de Medicina, Universidade do Porto
2021/08/15 Design of bioconjugated lipid nanoconstructs to act site-specifically towards glioblastoma growth impairment The 2021 International Symposium on Biomedical Engineering and Computational Biology (BECB 2021), Invited Talk - BECB-MS-1025
2021/07/27 Surface-functionalized lipid nanoparticles for glioblastoma treatment Controlled Release Society, Annual Meeting and Exposition 2021, Virtual Meeting
2021/07/23 Lipid nanoparticle functionalization for brain drug targeting IV Workshop Maestría en Biotecnología, Univerisad de Santander, UDES, Colômbia
2021/06/25 Nanopartículas lipídicas de superfície funcionalizada para o tratamento do glioblastoma Curso avançado: Bionanossistemas para aplicações farmacêuticas e cosméticas
CF-UM-UP, Departamento de Física da Universidade do Minho
2021/06/15 Formular para contornar a barreira cutânea WEBINARS da Parte 2 do Curso Pós-Graduado de Atualização em Cosmetologia
2021/04/21 On demand for new process analytical technologies applied to injectable drug products PAT & QbD - CPhi Conferences, Informa Markets
2021/03/15 Lipid nanoparticles for drug targeting to the brain Advanced Drug Delivery 2021 Doctoral Program
Faculdade de Farmácia, Universidade de Lisboa
2021 Solid lipid nanoparticles for transdermal drug delivery: where are we? Carla Vitorino 1st Symposium on Advanced Technologies for Drug Delivery
Faculdade de Farmácia, Universidade de Lisboa
2021 Computational design of peptide-carbohydrate conjugates to improve drug recognition and tumor targeting Tânia F. Cova, Maria Mendes, João Basso, M. Luísa Ramos, Rui Vitorino, João Sousa, Alberto Pais, Carla Vitorino International Symposium on Biomedical Engineering and Computational Biology (BECB 2021), online 13-15 August 2021.
2021 Can we improve pain management with topical fixed-dose combinations? Cláudia Veloso, Catarina Cardoso, Carla Vitorino Flash talk Sunset Skin Summit, 8-9 setembro, 2021
2021 A new hydrogel formulation enriched in molecules able to prevent allergic contact dermatitis: in vivo proof-of-concept Gonçalo Brites, Isabel Ferreira, Ana Silva, Carla Vitorino, Bruno Neves, Maria Teresa Cruz Flash talk Sunset Skin Summit, 8-9 setembro, 2021
2020/07/23 Surface-functionalized lipid nanoparticles for glioblastoma treatment Bionanosystems for pharmaceutical and cosmetic applications
Universidade do Minho (Braga, Portugal)
2020/06/29 Shaping the surface of lipid nanoparticles to site-specifically inhibit glioblastoma growth 2020 CRS Annual Meeting & Exposition
2020/06 Surface-functionalized lipid nanoparticles for glioblastoma treatment Controlled Release Society, Annual Meeting and Exposition 2020, Virtual Meeting, Las Vegas, Nevada, USA, 28 junho – 1 julho
2020 Computational Modeling Of Aptamer- And Peptide-carbohydrate Conjugates As A New Strategy To Improve Drug Recognition And Tumor Targeting Controlled Release Society, Annual Meeting and Exposition 2020, Virtual Meeting, Las Vegas, Nevada, USA, 28 junho – 1 julho
2019/12/12 Designing lipid nanoparticles for intranasal delivery of antidepressants Drug Delivery to the Lungs 2019
2019/11/15 aQbD as a Framework for in vitro Release Testing Development 1st Annual Meeting in Pharmaceutical Sciences
FFUC
2019/11/03 Engineered cationic ultra-small lipid nanoparticles for glioblastoma treatment Okinawa Colloids 2019
(Japan)
2019/11/03 Computational modeling of drug recognition and free-energy patterns in cyclodextrin-based nanostructures Okinawa Colloids 2019
(Japan)
2019/09/03 The many facets of cyclodextrins GLUPOR13
I3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2019/07/21 aQbD as a platform for IVRT method development – a regulatory oriented approach 2019 CRS Annual Meeting & Exposition
Valencia
2019/07/18 Lipid nanoparticles in drug delivery: What have we learned so far? 8th Iberian Meeting on Colloids and Interfaces: RICI 8
(Aveiro, Portugal)
2019/06/19 Nanotechnology and glioblastoma: What have we learned so far? Nanotechnology and brain drug delivery
Faculty of Pharmacy, University of Coimbra (Coimbra, Portugal)
2019/06/19 aQbD as a Framework for in vitro Release Testing Development Nanotechnology and brain drug delivery
FFUC
2019/06/19 Process analytical technologies and injectable drug products: Is there a future? Nanotechnology and brain drug delivery
FFUC
2019/06/19 A practical framework for implementing Quality by Design to the development of topical drug products: Nanosystem-based dosage forms Nanotechnology and brain drug delivery
FFUC
2019/06/19 aQbD as a multiaddressable platform for co-encapsulating drug assays Nanotechnology and brain drug delivery
FFUC
2018/10/12 Tailoring ultra-small lipid nanoparticles for glioblastoma treatment International Conference on Drug Delivery and Nanomedicine
(Stockholm, Sweden)
2018/06/13 Ultra-small lipid nanoparticles for brain drug delivery Bionanosystems for pharmaceutical and cosmetic applications
University of Minho (Braga, Portugal)
2018/01/22 Ultra-small lipid nanoparticles for brain drug delivery III International Symposium on Nanoparticles/Nanomaterials and Applications
(Caparica, Portugal)
2017/11/09 Can lipid nanoparticles improve oral absorption? III International Conference on Clinical Sciences & Drug Discovery
(Washington D.C, United States)
2017/07/04 Hybrid nanoparticles for oral drug administration VII Iberian Meeting on Colloids and Interfaces (RICI7)
(Madrid, Spain)
2016/10/19 Lipid nanoparticles: a versatile platform for drug delivery Bionanosystems Characterization Workshop
Faculty of Sciences and Technology, Universidade Nova de Lisboa (Lisbon, Portugal)
2016/04/01 Assuntos regulamentares Comunicação oral no II Dia de Farmácia Biomédica, Licenciatura em Farmácia Biomédica
(Coimbra, Portugal)
2016/03 Nanopartículas lipídicas Comunicação oral no Departamento de Química, Licenciatura em Química Medicinal
University of Coimbra (Coimbra, Portugal)
2015/11 Sistemas transdérmicos Seminário na Faculdade de Farmácia, Licenciatura em Química Medicinal
University of Coimbra (Coimbra, Portugal)
2014/06/07 Cosmetologia e higiene íntima feminina 5as Jornadas Atlânticas em Cuidados Farmacêuticos, Ordem dos Farmacêuticos
(Porto, Portugal)
2014/04/28 Nanopartículas lipídicas Comunicação oral no Departamento de Engenharia Química
University of Coimbra (Coimbra)
2014/04/14 A rapid reversed-phase HPLC method for the simultaneous analysis of olanzapine and simvastatin in dual nanostructured lipid carriers 7th Symposium of the Analytical Division, SPQ-Analítica-2014
Faculty of Sciences and Technology, University of Coimbra (Coimbra, Portugal)
2013/11/27 Dual nanostructured lipid carrier formulation – physicochemical, rheological and mechanical characterization Conferência CEF 2013
Faculty of Pharmacy, University of Coimbra (Coimbra, Portugal)
2012/10/25 Lipid nanoparticles as transdermal drug delivery systems: in vitro vs. in vivo Conferência CEF 2012
Faculty of Pharmacy, University of Coimbra (Coimbra, Portugal)
2012/06/04 Lipid nanoparticles as transdermal drug delivery systems: an in vitro-in vivo approach 4th Symposium, Skin & Formulation
(Lyon, France)
2011/06/13 Nanostructured lipid carriers as transdermal drug delivery systems Conferência CEF 2011
Faculty of Pharmacy, University of Coimbra (Coimbra, Portugal)
2010 Lipid nanoparticles as controlled drug delivery systems Conferência CEF 2010
Faculty of Pharmacy, University of Coimbra (Coimbra, Portugal)
2009/04/24 Novos sistemas terapêuticos para a via transdérmica Simpósio Novos Medicamentos Manipulados e Novos Sistemas Terapêuticos
(Porto, Portugal)

Supervision

Thesis Title
Role		 Degree Subject (Type)
Institution / Organization
2026 - Current A self-propelling lipid nanoparticle system for enzyme-responsive glioblastoma therapy
Supervisor
2026 - Current A triple-edged sword against melanoma: bilayer dissolving microneedle system for photothermal, chemodynamic, and gene therapy
Co-supervisor
2026 - Current Bridging generics to innovation: a quality-by-design approach for rosacea treatment
Supervisor
2026 - Current Optimizing HaPILLness Technology to a DIY format for Oral Drug Delivery in Rodent Models: Applications in Epilepsy field
Co-supervisor
2026 - Current Drug-device combination products: regulatory framework
Co-supervisor
2025 - Current Nanoparticle-embedded microneedle patches for precise local treatment of glioblastoma
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2024 - Current Artificial intelligence as a catalyst for regulatory harmonization in pharmaceutical drug approvals
Supervisor
2023 - Current Hidrogel carregado com Células Estaminais para o tratamento de queimaduras, produzido através de impressão 4D e otimizado por Machine Learning em Digital Twins
Co-supervisor
 PhD (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2023 - Current A Regulatory Framework for Bioequivalence Assessment of Topical Drugs
Supervisor
 PhD (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2021 - Current Advanced Therapies for Glioblastoma
Supervisor
2020 - Current Quality by Design: Approach for Analytical Methods
Supervisor
2019/09/01 - Current Biohybrid Nanosystems to co-deliver Drug and Nucleic Acid for Glioblastoma Treatment
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/04/01 - Current Models for pre-clinical evaluation of topical formulations
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - Current Development of a real-time release strategy using process analytical technologies tools applied to injectable formulations
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2017 - Current Pharmaceutical product development based on a Quality by Design approach
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2017 - 2022/11/04 Lipid nanoparticles as a multifunctional platform for brain tumor therapy
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2017 - 2022/07 Development and validation of analytical procedures for bioavaibility assessment of topical generic drug products
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2020/09/01 - 2021/07/21 DEVELOPMENT AND OPTIMIZATION OF METHODOLOGIES TO ASSESS BUCCAL PERMEATION
Supervisor
Universidade de Coimbra, Portugal
2021 - 2021 Otimização de processos para a caraterização de nanopartículas lipídicas sólidas para a administração de fármacos
Supervisor
2020 - 2021 Nanobolhas: princípios, aplicações Farmacêuticas e perspetivas futuras
Supervisor
2020 - 2021 Continuous manufacturing: Hype or Reality?
Supervisor
2020 - 2021 Nanocelulose: avanços e perspetivas futuras em tecnologia farmacêutica
Supervisor
2019 - 2020 Advances and Future Perspectives in 4D Bioprinting
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2020 Organ-on-a-chip
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2020 Paediatric Drug Development and Formulation Design-a Regulatory Perspective
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2019/09 Magnetic nanoparticles: A novel platform for cancer theranostics
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2018 - 2019 O papel da nanomedicina no tratamento do cancro do pulmão
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2018 - 2019 Desenvolvimento farmacêutico de sistemas transdérmicos: estratégias e oportunidades
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2018 - 2018 Development of Lipid-based Nanoparticles for oral insulin delivery
Co-supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2018 - 2018 Design and characterization of lipid nanoparticle formulations for antibiotic delivery
Co-supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2018 - 2018 Film based on NLC for co-delivery of olanzapine and simvastatin
Co-supervisor
Universidad Nacional de Río Cuarto, Argentina
2017 - 2018 Inkjet Printing: A novel approach for manufacturing personalized medicines
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2017 - 2018 Nanoteranóstica e medicina personalizada
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2017 - 2018 Nanofibers: production, characterization and biomedical applications
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2018 Generic drug product development of a modified-release oral dosage form
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2018 Oral films based on lipid nanoparticles for drug administration: a computational and experimental approach
Co-supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2018 Otimização de nanossistemas para administração dérmica de nitrato de miconazol
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2017 - 2017 Polyfunctional lipid-coated chitosan nanoparticles for melanoma treatment
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2017 - 2017 Cationic lipid nanoparticles for glioblastoma treatment
Supervisor
Universidade do Minho, Portugal
2016 - 2017 Polymer-lipid hybrid nanoparticles for oral delivery of antiepileptic drugs
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2017 Nanomedicine: Prospects, Risks and Regulatory Challenges
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2017 Process Analytical Technology
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2017 Medicamentos órfãos
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2016 Nanogéis como sistemas para administração de sinvastatina
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2016 Encapsulação de Insumos Vegetais em nanopartículas de quitosano
Co-supervisor
Faculdade de Farmácia de Maringá, Brazil
2015 - 2016 Sistemas de administração transdérmica de fármacos: desafios e oportunidades
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2016 Nanopartículas lipídicas como transportadores de fármacos para o sistema nervoso central
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2016 Desenvolvimento farmacêutico de medicamentos genéricos para aplicação tópica: Desafios e perspetivas futuras
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2016 Encapsulação de Insumos Vegetais em Nanocarreadores Lipídicos Inovadores Funcionalizados com Biomoléculas como Estratégia para o Tratamento da Leishmaniose
Co-supervisor
Faculdade de Farmácia , Portugal
2015 - 2016 Desenvolvimento de nanotransportadores para administração de fármacos para o sistema nervoso central
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2016 Lipid nanoparticles as a versatile system for drug delivery
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2016 Impact of formulation and process variables, in technological features of dosage forms for skin delivery
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2015 Iontoforese: aplicação na administração transdérmica de fármacos
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2015 Transdermal delivery of olanzapine for the treatment of psychiatric disorders, Internship 3rd stage, Erasmus UCL
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2015 Medicamentos manipulados para uso pediátrico. Conjuntura actual e perspectivas futuras
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2015 Sistemas transdérmicos no tratamento da dor crónica
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2015 Needle-free drug delivery
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2014 Influência de parâmetros críticos no processo de transposição de escala de nanopartículas lipídicas
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2014 Desenvolvimento de nanopartículas lipídicas para administração tópica de PFD
Co-supervisor
Centro de Química, Instituto Nacional de Tecnología Industrial, Argentina
2013 - 2014 Nanopartículas lipídicas como sistema para administração de fármacos anticancerígenos
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2013 - 2014 Microneedles e o seu papel na permeação cutânea
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2013 - 2014 Nanocristais: aplicações em tecnologia farmacêutica
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2013 - 2014 Novas estratégias para administração de proteínas e peptídeos
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2013 - 2014 Nanopartículas lipídicas como sistemas de administração de fármacos por via oral e transdérmica
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2013 - 2013 Optimization of lipid nanoparticle properties
Co-supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2012 - 2013 Nanopartículas lipídicas como sistemas de adminsitração de fármacos
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2012 - 2013 Sistemas nanoestruturados e a pele
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2012 - 2013 Sistemas transdérmicos
Supervisor
Faculty of Pharmacy, University of Coimbra, Portugal
2011 - 2011 Preparação de nanopartículas lipídicas para administração transdérmicas de fármacos
Co-supervisor
Faculty of Pharmacy, University of Coimbra, Portugal

Event organisation

Event name
Type of event (Role)		 Institution / Organization
2011/09/27 - Current Member of the organizing committee of the Conference CEF2011 (2011)
Conference (Member of the Organising Committee)
 Faculty of Pharmacy, University of Coimbra, Portugal
2011/05/19 - Current Member of the organizing committee of the 1st Workshop on Pharmaceutical Technology (2011/05/19)
Workshop (Member of the Organising Committee)
 Faculty of Pharmacy, University of Coimbra, Portugal
2019/06/19 - 2019/06/19 Nanotechnology and brain drug delivery (2019)
Workshop
 Faculty of Pharmacy, University of Coimbra, Portugal

Event participation

Activity description
Type of event		 Event name
Institution / Organization
2014/03 - 2014/06 Researcher in CoHiTeC 2014: Turning science into business
Other
Faculty of Pharmacy, University of Coimbra, Portugal

Jury of academic degree

Topic
Role		 Candidate name (Type of degree)
Institution / Organization
2024 Quality by Design (QbD) approach for the development of oromucosal drug delivery systems
(Thesis) Arguer
 Francisca de Barros Bastos Gaudêncio e Silva (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2024 Pharmaceutical Product Development Based on a Quality by Design Approach
Supervisor
 Ana Isabel de Oliveira Simões Martins (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2024 Gene Editing Nanoformulations for Brain Applications
(Thesis) Arguer
 Francesca Tomatis (PhD)
2024 Functionalized lipid nanocarriers to overcome the blood-brain barrier in the treatment of amyotrophic lateral sclerosis
(Thesis) Main arguer
 Maria Inês Teixeira (PhD)
2024 Gene Editing Nanoformulations for Brain Applications
(Thesis) Arguer
 Francesca Tomatis (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2024 Pharmacological Strategies to Target Cellular Senescence
(Thesis) Arguer
 Inês Tomé Ribeiro (PhD)
2024 Development of a real-time release strategy using process analytical technologies tools applied to injectable formulations
Supervisor
 João Pedro Guerra Henriques (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2023 Taste signalling in glioblastoma
(Thesis) Main arguer
 Ana Raquel Ferreira da Costa (PhD)
2022 Topical bioequivalence: experimental and regulatory considerations
Supervisor
 Margarida Miranda Rodrigues (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2022 Hybrid nanoparticles as multifunctional platform for brain tumor therapy
Supervisor
 Maria Manuel Feliciano da Costa Mendes (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2022 Strategic and advancing regulatory science approach in pharmaceutical development of complex generic drug products
(Thesis) Arguer
 Daniela Mariana Marques Zagalo (PhD)
2022 NeuroD3S – Dual-Drug Delivery System based on cell-penetrating peptides and nanoparticles for application in biomedicine
(Thesis) Main arguer
 Sara Cristina Pinto Silva (PhD)
2021/11/10 Development of a new pharmacokinetic model using in silico studies, drug delivery systems and analytical methods Abigail Filipe Ferreira (PhD)
2021/04/05 Tailoring challenging drug properties through solid dispersions Marta Cristina Filipe Simões (PhD)
2020 Nanococristais farmacêuticos: Síntese, caracterização e otimização de processos João Afonso Sêco Vieira Santos (Master)
2020 Solid lipid nanoparticles as drug delivery systems in the treatment of Glioblastoma multiforme Raneem Jnaidi (Master)
2019/07/19 Sensibilizadores cutâneos: novas abordagens para previsão de toxicidade e gestão do risco Filipa Alexandra Lopes Simões da Silva (Master)
2019/03/21 Desenvolvimento e otimização de nanoformulações lipídicas com ação microbicida anti-VIH Maria João Fernandes Faria (Master)
2019 Dendrimers as Pharmaceutical excipients Ana Isabel Caldeira Freitas dos Santos (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 O papel do farmacêutico na farmacogenómica Marta Rebelo Viegas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 Associação da Nanotecnologia com a terapêutica do melanoma Inês Torres Carvalhosa (Master)
2019 Avaliação farmacoeconómica em Portugal Vanessa Anjos de Oliveira (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 Limulus amebocyte lysate: as suas aplicações na biomedicina Bruno Filipe Brites Fernandes Oliveira (Master)
2018/09 Comprimidos Orodispersíveis: Enquadramento regulamentar de acordo com a EMA versus FDA
(Thesis) Arguer
 Nancy Cristina Domingues Marques (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2018/09 Administração Intranasal de Antidepressivos e Antipsicóticos: Realidade Pré-Clínica e Clínica
(Thesis) Arguer
 Isabel Fragoso Simões (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2018/03/01 Generic drug product development of a modified-release oral dosage form
Supervisor
 Sara Cardoso (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/12/15 Sex, Drugs and Excipients: PEG 400 enhances the bioavailability of BCS class III drugs via P-glycoprotein inhibition
(Thesis) Arguer
 Francisco de Matos Afonso Pereira (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/12/13 Desenvolvimento de um sistema nanoestruturado para co-encapsulação de aciclovir e ácidos gordos ómega-3 por electrospinning
(Thesis) Arguer
 Tiago Miguel Castro Costa (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/10/13 Hybrid nanoparticles for oral delivery of antiepyletic drugs
Supervisor
 Raquel da Ana (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/10/13 Development of a proliposome formulation as a drug carrier for a novel antitumor drug
(Thesis) Arguer
 Ana Daniela Coutinho Alves (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/09/22 Development and validation of analytical procedures for bioavaibility assessment of topical generic drug products Margarida Isabel Silva Coutinho de Miranda (Other)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09 Desenvolvimento farmacêutico baseado no Quality by Design
(Thesis) Arguer
 Ana Rita Neves Figueiredo (Master)
2017/09 Understanding Quality by design with Monoclonal Antibodies
(Thesis) Arguer
 João Diogo Basso da Silva Torres (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/09 A Hepatite C – Novas Opções Terapêuticas
(Thesis) Arguer
 Afonso Sousa Machado de Pereira Monteiro (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/09 Cancer drugs: Market and Sustainability
(Thesis) Arguer
 Luís Ricardo Ribeiro Correia (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/09 Aplicação de complexos micelares na administração de RNA
(Thesis) Arguer
 Rita José Ramos Martins (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2017/09 Aplicação de complexos micelares na administração de RNA
(Thesis) Arguer
 Rita José Ramos Martins (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2016/09 Vetores não virais com aplicação na terapia génica: os poliplexos
(Thesis) Arguer
 Ana Patrícia Loureiro (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2016/09 Uveal melanoma: physiopathology and new situ:specific therapies
(Thesis) Arguer
 Madalena Luís (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2016/09 Exosomes: an emerging strategy to treat autoimmune and inflamatory diseases Carmelita Sousa (Master)
2016/09 Nanotecnologia: solução às resistências bacterianas
(Thesis) Arguer
 Cristiana Pinheiro (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2016/09 Nutricosméticos e cosmecêuticos: condicionantes regulamentares e posicionamento no mercado atual
(Thesis) Arguer
 Mariana Gonçalves (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2016/07/29 Lipid nanoparticles as a versatile system for drug delivery
Supervisor
 Mafalda Vaz (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2016/07/01 Lipid nanoparticles as a versatile system for drug delivery
(Thesis) Arguer
 Maria Manuel Feliciano da Costa Mendes (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2016/04/20 Novel particulate BCG-loaded delivery system for mucosal immunization against tuberculosis
(Thesis) Arguer
 Liliana Caetano (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2016/04/11 Cationic lipid nanomedicines for the treatment of diabetic retinopathy
(Thesis) Arguer
 Joana Fangueiro (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2015/09 Investigação clínica em pediatria
(Thesis) Arguer
 Catarina Monteiro (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2015/09 Estratégias para administração de fármacos pouco solúveisa
(Thesis) Arguer
 Marina Marques (Master)
Faculty of Pharmacy, University of Coimbra, Portugal
2015/04/23 Pharmaceutical development of local anesthetics formulations for topical administration
(Thesis) Arguer
 Raquel Teixeira (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2014/12/01 Nanotecnologia aplicada a formulações tópicas de fármacos anti-inflamatórios não esteróides
(Thesis) Arguer
 Giuliana Mancini (PhD)
Faculty of Pharmacy, University of Coimbra, Portugal
2014/07 Influência de parâmetros críticos no processo de transposição de escala de nanopartículas lipídicas
Supervisor
 Diana Santos (Other)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07 Nanopartículas lipídicas como sistemas de administração de fármacos por via oral e transdérmica
Supervisor
 Maria Mendes (Other)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07 Aplicações da nanotecnologia em doenças do foro neurológico: vantagens e desafios
(Thesis) Arguer
 Ana Alexandra Miranda (Master)
Faculty of Pharmacy, University of Coimbra, Portugal

Association member

Society Organization name Role
2024 - Current COST Action 21108. European Network for Skin Engineering and Modeling (Netskinmodels) Member
2023 - Current CA22103 - A COMPREHENSIVE NETWORK AGAINST BRAIN CANCER (Net4Brain) COST Action Management Committee
2022 - Current TRANSLACORE (COST Action CA21154) Translational control in Cancer European Network Member
2021 - Current Membro COST ACTION CA17103 - Delivery of Antisense RNA Therapeutics
2020/07/01 - Current COST Action CA17140 - Nano2Clinic - Cancer Nanomedicine - from the bench to the bedside Action Participant
2007 - 2014 Ordem dos Farmacêuticos Member N.º C-2739, CP N.º 15424
2010 - 2011 American Association of Pharmaceutical Sciences Member N.º 199181

Committee member

Activity description
Role		 Institution / Organization
2022 - Current Member of the Pedagogical Board of the Faculty of Pharmacy at the University of Coimbra
2018 - Current Assistant Coordinator of the ERASMUS students, http://www.uc.pt/ects/info_inst/coord_dept/#ancora5.
Coordinator
 Faculty of Pharmacy, University of Coimbra, Portugal

Conference scientific committee

Conference name Conference host
2015/11/05 - Current Panel II – Oncology, IX Congresso Científico Anual
2018/10/09 - 2018/10/12 Chair - Session I: Cancer: Causes, Prevention and Treatment International Conference on Drug Delivery and Nanomedicine, Stockholm, Sweden
2018/10/09 - 2018/10/12 Poster Jury - International Conference on Drug Delivery and Nanomedicine, Stockholm, Sweden
2017/11/02 - 2017/11/03 Panel V - Biological Drugs
2015/11/10 - 2015/11/11 Painel III – Orphan drugs and clinical assays - X Congresso Científico Anual

Consulting

Activity description Institution / Organization
2025 - Current European Commission Evaluator
2021 - Current Project Peer Reviewer Science Fund of Poland
2021 - Current Project Peer Reviewer Science Fund of New Zeland
2020/11 - Current Project Peer Reviewer of the Science Fund of the Republic of Serbia.
2013 - Current Spray-drying, Texture analysis, Scanning electron microscopy Faculty of Pharmacy, University of Coimbra, Portugal
2013 - Current Development of strategic plans for the feasibility of drug development. Faculty of Pharmacy, University of Coimbra, Portugal
2013 - Current Scanning Electron Microscopy, Laboratory of Pharmaceutical Technology Faculty of Pharmacy, University of Coimbra, Portugal
2017 - 2017 Technical support of the Unidade de Saboaria Artesanal CEARTE

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/10 - Current Coordinator of the Masters in Pharmaceutical Technology - Faculty of Pharmacy, University of Coimbra
2020 - 2022 Assuntos regulamentares & Patentes PhD Program Drugs R&D / Pharmaceutical Sciences (Doutoramento) Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2021 Seminários I e II - Tutoria PhD Program Drugs R&D / Pharmaceutical Sciences (Doutoramento) Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2021 Procedimentos Operativos Normalizados e Gestão de Dados Biomedical Pharmacy (Licenciatura) Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2021 Assuntos regulamentares do medicamento Pharmaceutical Sciences (Mestrado integrado) Faculty of Pharmacy, University of Coimbra, Portugal
2017 - 2018 Tecnologia Farmacêutica I - 2021/22 Pharmaceutical Sciences (Mestrado integrado) Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2018 New frontiers in drug development PhD Program Drugs R&D / Pharmaceutical Sciences (Doutoramento) Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2018 Tecnologia Farmacêutica II Pharmaceutical Sciences (Mestrado integrado) Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2017 Regulamentação no Desenvolvimento do Medicamento - 2021/22 Biomedical Pharmacy (Licenciatura) Faculty of Pharmacy, University of Coimbra, Portugal
2016 - 2017 Regulamentação no Desenvolvimento do Medicamento - 2021/22 Biomedical Pharmacy (Licenciatura) Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2016 Gestão e garantia da qualidade Pharmaceutical Sciences (Mestrado integrado) Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2016 Documentação e Boas Práticas regulamentares Medicine Technologies (Mestrado) Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2016 Tecnologias dos Sistemas de libertação modificada Medicine Technologies (Mestrado) Faculty of Pharmacy, University of Coimbra, Portugal
2015 - 2016 Seminários temáticos Medicine Technologies (Mestrado) Faculty of Pharmacy, University of Coimbra, Portugal
2014 - 2016 Gestão de projetos de desenvolvimento Medicine Technologies (Mestrado) Faculty of Pharmacy, University of Coimbra, Portugal
2012 - 2014 Tecnologia Farmacêutica III Pharmaceutical Sciences (Mestrado integrado) Faculty of Pharmacy, University of Coimbra, Portugal
2011 - 2014 Tecnologia Farmacêutica III Pharmaceutical Sciences (Mestrado integrado) Faculty of Pharmacy, University of Coimbra, Portugal
2009 - 2014 Farmácia Galénica Pharmaceuticla Sciences (Mestrado integrado) Faculty of Pharmacy, University of Coimbra, Portugal
2012 - 2013 Dermofarmácia e cosmética Pharmaceutical Sciences (Mestrado integrado) Faculty of Pharmacy, University of Coimbra, Portugal
2012 - 2013 Controlo de Qualidade do Medicamento Bioanalytic Sciences (Licenciatura) Faculty of Pharmacy, University of Coimbra, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Review Editor on the Editorial Board of Biomaterials (specialty section of Frontiers in Materials, Frontiers in Bioengineering and Biotechnology and Frontiers in Molecular Biosciences).
2020 - Current Processes
2018 - Current Clinics in Oncology
2018 - Current International Journal of Drug Safety and Discovery
2018 - Current European Journal of Molecular Cancer

Other jury / evaluation

Activity description Institution / Organization
2019 - Current Seminário II – Programa Doutoral em Ciências Farmacêuticas Models for pre-clinical evaluation of topical formulations
2018/07/30 - Current Development of a Medical Device for prevention of Allergic Contact Dermatitis Seminário I - Arguente Gonçalo Sousa Brites Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/07/25 - Current Development of a real-time release strategy using process analytical technologies tools applied to injectable formulations João Pedro Guerra Henriques Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/05/11 - Current Maria Manuel Feliciano da Costa Mendes Theranostic nanoparticles as a multifunctional platform for brain tumor therapy Seminário I – Programa Doutoral em Ciências Farmacêuticas Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/05/11 - Current Targeted theranostic nanoparticles for brain tumor treatment Seminário II – Programa Doutoral em Ciências Farmacêuticas Maria Manuel Feliciano da Costa Mendes Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/22 - Current Margarida Isabel Silva Coutinho de Miranda Development and validation of analytical procedures for bioavaibility assessment of topical generic drug products Seminário I – Programa Doutoral Drugs R&D (Empresa: Basi) Universidade de Coimbra Faculdade de Farmácia, Portugal
Distinctions

Award

2025 Best poster presentation - Francisco Branco (PhD student)
CRS Italy Workshop, Italy
2025 Best oral communication - Francisco Branco (PhD Student)
2023 Supervisor of PhD Student João Basso - Best Oral Presentation in Pharmaceutical Technology and Biotechnology
2023 Supervisor of PhD Student João Basso - Best Poster presentation
2023 "APV Award for the Most Outstanding Doctoral Thesis 2022/23”. Maria Manuel da Costa Mendes. Supervisory Team: Carla Vitorino, João José Sousa and Alberto Pais. 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienna
2022 Research Award – Faculty of Pharmacy of the University of Coimbra, Coimbra Student Association, Honoris Pharma 2022
2021 Young Investigator Award, Bioinspired and Biomimetic Delivery Focus Group, Controlled Release Society 2021
2020 Best paper special issue: Targeted theranostic nanoparticles for brain tumor treatment Maria Mendes, João J. Sousa, Alberto A. C. C. Pais, Carla Vitorino, Pharmaceutics 10:4 (2018) 181, doi: https://doi.org/10.3390/pharmaceutics10040181
2008 PhD Grant SFRH/BD/41536/2007
Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2024 Included in the list of “World’s Top 2% Scientists” by the Elsevier publishing group (https://www.uc.pt/ffuc/destaques/worlds-top-2-scientists-list-2023-faculdade-de-farmacia-da-universidade-de-coimbra-conta-este-ano-com-mais-um-investigador/)
2023 Included in the list of “World’s Top 2% Scientists” by the Elsevier publishing group (https://noticias.uc.pt/artigos/77-cientistas-da-universidade-de-coimbra-entre-os-mais-citados-do-mundo-segundo-a-lista-worlds-top-2-scientists/)
2022 Included in the list of “World’s Top 2% Scientists” by the Elsevier publishing group (https://www.uc.pt/fctuc/deec/ffuc/article?key=a-4758548aef)
2007 Awarded prize for being in the 3% best students in the University of Coimbra
Universidade de Coimbra, Portugal