As the ERA Chair Holder for the iSTARS project and an Invited Full Professor at the University of Lisbon (FMUL), I lead a multidisciplinary research program at the intersection of Artificial Intelligence (AI) and medicine. My expertise lies in architecting machine learning solutions that leverage complex health data, including genomics, to improve clinical decision-making. My background spans diverse expertises, from developing predictive sequence-activity models for gene regulation during my doctoral work, to employing systems biology and multiomics approaches to study cancer and immunoregulation during my postdoctoral training. These efforts were highly productive, resulting in numerous high-impact publications. My unique trajectory also includes leading data science teams in industry at Roche and Farfetch. This experience in high-scale commercial data environments provided me with a distinct perspective on technical scalability and operational management. In 2023, I have returned to academia to establish a research group in health data science and genomics, uniquely positioned to bridge the gap between experimentalists, clinicians, and data scientists.