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Ph.D. in Electronic and Telecommunications Engineering (2019-2023) at University of Algarve. BSc and MSc degrees in Biomedical Sciences (2007-2011 and 2013-2016, respectively) got from the Department of Biomedical Sciences and Medicine, University of Algarve. PhD represents years of rigorous exploration into cell bioelectrical activity through the use of extracellular electrodes in in vitro settings. This foundational work laid for the subsequent groundbreaking discoveries in the characterization of bioelectrical activity in astrocytes and cancer cells. Furthermore, a pioneering biosensor emerged from this research, demonstrating an exceptional capacity to discriminate and quantify the unique electrical signatures of cancer cells. This innovative tool enables precise assessment of cancer cell migratory behaviour. With its versatility and precision, this biosensor stands as a powerful instrument in the realm of drug screening.
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Identification

Personal identification

Full name
Ana Luísa Garcias Mestre
Date of birth
1988/07/01
Gender
Female

Citation names

  • Mestre, Ana L. G.

Author identifiers

Ciência ID
601B-4B7D-ABC3
ORCID iD
0000-0002-6679-8698

Email addresses

  • g.ana.mestre@gmail.com (Personal)

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2019/10/01 - 2023/09/18
Concluded
 Engenharia Electrónica e Telecomunicações (Doutoramento)
Major in BioElectrónica
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Ultra-sensitive bioelectronic transducer to monitor electrical activity in cell populations" (THESIS/DISSERTATION)
 Very good with honors and distinction
2013/09 - 2016/02
Concluded
 Ciências Biomédicas (Mestrado)
Major in BioElectrónica
Universidade do Algarve, Portugal
"Cellular behavior of neuronal and glia cells in electronic devices" (THESIS/DISSERTATION)
 18
2007/09 - 2011/04
Concluded
 Ciências Biomédicas (Licenciatura)
Major in Biomedicine
Universidade do Algarve - Campus de Gambelas, Portugal
"O Papel da Proteómica na descoberta de Biomarcadores de Doença, Class. final: 17 valores (0-20)" (THESIS/DISSERTATION)
 13
Affiliation

Others

Category
Host institution 		Employer
2019/10/01 - 2023/09/19 PhD student Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Telecomunicações, Portugal
(...)
2018/06/01 - 2019/06/01 Bolseira de investigação no âmbito do projeto INNOVATE PTDC/EEI-AUT/5442/2014 Instituto de Telecomunicações, Portugal
2015/03/01 - 2018/05/01 Bolseira de Investigação, Fundo de Ivestigação Henrique Gomes, Caracterização elétrica de componentes bioeletrónicos para mediar sinais fracos em culturas de células. Universidade do Algarve, Portugal
2013/01/01 - 2015/02/01 Bolseira de Investigação, Projeto Implantable Organic Nano-Electronics (I-ONE-FP7 (Grant Agremment. N.º 280772) Universidade do Algarve - Campus de Gambelas, Portugal
2012/03/01 - 2012/08/28 Estagiária em “Investigação e Desenvolvimento Biomédico de Radiofármacos Emissores de Positrões” Centro Uruguayo de Imagenología Molecular, Uruguay
Outputs

Publications

Journal article
  1. Inácio, Pedro M.C.; Medeiros, Maria C.R.; Carvalho, Tiago; Félix, Rute C.; Mestre, Ana; Hubbard, Peter C.; Ferreira, Quirina; et al. "Ultra-low noise PEDOT:PSS electrodes on bacterial cellulose: A sensor to access bioelectrical signals in non-electrogenic cells". Organic Electronics 85 (2020): 105882. http://dx.doi.org/10.1016/j.orgel.2020.105882.
    10.1016/j.orgel.2020.105882
  2. Mestre, Ana L. G.. "Extracellular electrophysiological based sensor to monitor cancer cells cooperative migration and cell-cell connections". Biosensors and Bioelectronics (2019): http://dx.doi.org/10.1016/j.bios.2019.111708.
    10.1016/j.bios.2019.111708
  3. Mestre, Ana L. G.. "Ultrasensitive bioelectronic devices based on conducting polymers for electrophysiology studies". Chemical Papers (2018): http://dx.doi.org/10.1007/s11696-018-0481-z.
    10.1007/s11696-018-0481-z
  4. Mestre, Ana L. G.. "Ultrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populations". Scientific Reports (2017): http://dx.doi.org/10.1038/s41598-017-14697-y.
    10.1038/s41598-017-14697-y
  5. Mestre, Ana L. G.. "Extracellular Electrophysiological Measurements of Cooperative Signals in Astrocytes Populations". Frontiers in Neural Circuits (2017): http://dx.doi.org/10.3389/fncir.2017.00080.
    10.3389/fncir.2017.00080
  6. Mestre, Ana L. G.. "Bioelectrical Signal Detection Using Conducting Polymer Electrodes and the Displacement Current Method". IEEE Sensors Journal (2017): http://dx.doi.org/10.1109/jsen.2017.2703834.
    10.1109/jsen.2017.2703834
  7. Mestre, Ana L. G.. "Extracellular electrical recording of pH-triggered bursts in C6 glioma cell populations". Science Advances (2016): http://dx.doi.org/10.1126/sciadv.1600516.
    10.1126/sciadv.1600516
  8. Mestre, Ana L. G.. "An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes". Sensing and Bio-Sensing Research (2016): http://dx.doi.org/10.1016/j.sbsr.2016.06.002.
    10.1016/j.sbsr.2016.06.002
  9. Mestre, Ana L. G.. "Electrochemically Gated Graphene Field-Effect Transistor for Extracellular Cell Signal Recording". Technological Innovation for Cyber-Physical Systems (2016): http://dx.doi.org/10.1007/978-3-319-31165-4_53.
    10.1007/978-3-319-31165-4_53
Newspaper article
  1. Sophia Letsiou; Rute C. Félix; João C. R. Cardoso; Liliana Anjos; Mestre, Ana L. G.; Henrique L. Gomes; Deborah Power. "Cartilage acidic protein 1 promotes increased cell viability, cell proliferation and energy metabolism in primary human dermal fibroblasts", 2020
    10.1016/j.biochi.2020.02.008
  2. Sanaz Asgarifar; Mestre, Ana L. G.; Pedro M. C. Inácio; Maria L. S. Cristiano; Maria C. R. Medeiros; Inês M. Araújo; Deborah M. Power; Henrique L. Gomes. "Extracellular electrophysiological based sensor to monitor cancer cell cooperative migration and cell-cell connections", 2019
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017/05/25 Electrical Detection of Extracellular Long-Lasting Potentials in Astrocytes II Symposium Portuguese Glial Network
Portuguese Glial Network (Braga, Portugal)
2017/04 Extracellular Electrical Recording using poly (L-lactic) acid coated electrodes Materials 2017
2015/11/23 Drug screening platform based on extracellular electrical noise measurements
(Manchester, United Kingdom)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/05/23 - 2019/05/24 Immunoneurophysiology course Københavns Universitet Sundhedsvidenskabelige Fakultet, Denmark