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Elsa Maria Alves Dias. PhD in Pharmacy (2009, University of Lisbon/Faculty of Pharmacy). Master’s in quality Control and Food Toxicology (2001, University of Lisbon/Faculty of Pharmacy). Degree in Biochemistry (1996, University of Lisbon/Faculty of Sciences). Researcher at National Institute of Health Dr. Ricardo Jorge. Publication of 30 papers in international peer reviewed journals, 2 book chapters and 6 national magazine articles. Supervision of 7 master students and 3 undergraduate interns. Cosupervision of 1 PhD and 5 master students. PI of 3 research projects. Team member of 9 projects. Research areas: Environmental Health, (Eco)Toxicology, Freshwater Biology. Keywords: Antibiotic Resistance; Environmental Resistome; Aquatic Microbiota; Cyanobacteria; Metagenomics; Genomics; Blooms; Cyanotoxins; Genotoxicity; Cytotoxicity; Risk Characterization.
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Identification

Personal identification

Full name
Elsa Maria Alves Dias

Author identifiers

Ciência ID
5D17-581A-8E11
ORCID iD
0000-0002-1797-4456
Scopus Author Id
7006951295

Email addresses

  • elsa.dias@insa.min-saude.pt (Professional)
Education
Degree Classification
2009/10
Concluded
 Farmácia (Doutoramento)
Major in Toxicologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Avaliação do potencial cancerigénico de microcistinas (cianotoxinas)." (THESIS/DISSERTATION)
 Aprovado com Distinção e Louvor
2001
Concluded
 Controlo de Qualidade e Toxicologia dos Alimentos (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Caracterização da produção de toxinas PSP numa estirpe de Aphanizomenon issatschenkoii (cianobactéria). Estudo da re-ocorrência de toxinas PSP na albufeira de Montargil. Implicações para a saúde pública" (THESIS/DISSERTATION)
 Muito Bom
1996
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Produção de uma proteína recombinante em culturas de células animais." (THESIS/DISSERTATION)
 14 valores
Affiliation

Science

Category
Host institution 		Employer
2019/03/15 - Current Auxiliary Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2012/03 - 2019/02 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Projects

Contract

Designation Funders
2023/12/01 - Current Joint Action on Antimicrobial Resistance and Healthcare-Associated Infections (EU-JAM-RAI 2)
101127787
Researcher
European Union
Ongoing
2023/11/01 - Current EU Wastewater Integrated Surveillance for Public Health (EU-WISH)
101140460)
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 European Union
Ongoing
2023/01/01 - Current Global Testing & Diagnostics Solutions for antimicrobial resistances (SMARTgNOSTICS)
PRR - Aviso 2021-C05i01-01 PRR
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 European Union
Ongoing
2025/02/03 - 2026/08/02 Cyanobacteria Bioactivity Against Legionella – an Ecofriendly Solution(CyaNoLeg)
2023.15669.PEX
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2022/06/30 FULL-FORCE: Full-length sequencing for an enhanced EFFORT to map and understand drivers and reservoirs of antimicrobial resistance (OHEJP)
JRP14-R2-AMR2.2-FULL-FORCE
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Horizon 2020
Concluded
2020 - 2022/06/30 FED-AMR: The role of free extracellular DNA in dissemination of antimicrobial resistance over ecosystem boundaries along the food/feed chain.
JPR15-R2-AMR2.2-FED-AMR
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Horizon 2020
Concluded
2020 - 2022/06/30 WORLDCOM - Development of new tools for real-time detection of zoonotic bacteria and antimicrobial resistance in veterinary, human and environmental sources.
JRP13-AMRSH5- WORLDCOM
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Horizon 2020
Concluded
2018/10/01 - 2021/09/30 Exploring Aquatic Resistome.
PTDC/BIA-BMA/31451/2017
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2012 WaterCork: Valorization of subproducts from the cork industry in the removal of organic contaminants from water - cyanotoxins
FEDER 005523
Other
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2006/01/01 - 2007/07/20 Natural Algaecides againts harmful microalgae
POCI/AMB/60351/2004
Other
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2023/01/01 - Current Antibacterial activity of cyanobacteria against veterinary pathogens
AL4A-PROJ-LT2.1
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Menezes, Carina; Valerio, Elisabete; Dias, Elsa. "The Kidney Vero-E6 Cell Line: A Suitable Model to Study the Toxicity of Microcystins". In New Insights into Toxicity and Drug Testing. InTech, 2013.
    Published • 10.5772/54463
  2. Churro, Catarina; Dias, Elsa; Valrio, Elisabete. "Risk Assessment of Cyanobacteria and Cyanotoxins, the Particularities and Challenges of Planktothrix spp. Monitoring". In Novel Approaches and Their Applications in Risk Assessment. InTech, 2012.
    10.5772/37910
Conference paper
  1. Dias, Elsa; Paulo Pereira; Maria Camila Canteiro Batoréu; Peter Jordan; Maria João Aleixo da Silva. "Cytotoxic and genotoxic effects of microcystins in mammalian cell lines". Paper presented in 12th International Conference on Harmful Algae, Copenhaga, 2006.
    Published
  2. Dias, Elsa; Susana Franca. "Persistence of paralytic shellfish toxins in freshwater environments". Paper presented in 10th International Conference on Harmful Algae, St. Petersburg - Florida, 2002.
    Published
Journal article
  1. Rivière, Rani; Teixeira, Pedro; Silva, Catarina; Ramos, Miguel; Dias, Elsa; Manageiro, Vera; Caniça, Manuela. "Unraveling the genome-wide repertoire of the novel chromosomally encoded mcr-8.6 gene variant in Klebsiella michiganensis isolated from manure". Frontiers in Microbiology 16 (2025): https://doi.org/10.3389/fmicb.2025.1673320.
    10.3389/fmicb.2025.1673320
  2. Teixeira, Pedro; Ramos, Miguel; Rivière, Rani; Azevedo, Mónica; Ferreira, Mário; Cano, Maria Manuela; Vieira, Patrícia; et al. "Genomic epidemiology and resistome dynamics of Enterobacter species in a Portuguese Open Air Laboratory: the emergence of the FRI-8 carbapenemase". Frontiers in Microbiology 16 (2025): https://doi.org/10.3389/fmicb.2025.1593872.
    10.3389/fmicb.2025.1593872
  3. Balata, Duarte; Rosado, Tânia; Pina-Martins, Francisco; Manageiro, Vera; Menezes, Carina; Ferreira, Eugénia; Paulo, Octávio S.; Caniça, Manuela; Dias, Elsa. "Prediction of Antibiotic Resistance Genes in Cyanobacterial Strains by Whole Genome Sequencing". Microorganisms 13 6 (2025): 1252. https://doi.org/10.3390/microorganisms13061252.
    10.3390/microorganisms13061252
  4. Cordeiro, Rita; Luz, Rúben; Lage, Sandra; Menezes, Carina; Dias, Elsa; Flores, Cintia; Fonseca, Amélia; Gonçalves, Vítor. "Metabolomic and taxonomic characterization of Haloleptolyngbya lusitanica sp. nov . (Cyanobacteria, Synechococcales)". Phycologia (2024): 1-10. http://dx.doi.org/10.1080/00318884.2024.2317252.
    10.1080/00318884.2024.2317252
  5. Salgueiro, Vanessa; Manageiro, Vera; Rosado, Tânia; Bandarra, Narcisa M.; Botelho, Maria João; Dias, Elsa; Caniça, Manuela. "Snapshot of resistome, virulome and mobilome in aquaculture". Science of The Total Environment 905 (2023): 166351. http://dx.doi.org/10.1016/j.scitotenv.2023.166351.
    10.1016/j.scitotenv.2023.166351
  6. Vera Manageiro; Vanessa Salgueiro; Tânia Rosado; Narcisa M. Bandarra; Eugénia Ferreira; Terry Smith; Elsa Dias; Manuela Caniça. "Genomic Analysis of a mcr-9.1-Harbouring IncHI2-ST1 Plasmid from Enterobacter ludwigii Isolated in Fish Farming". Antibiotics (2022): https://www.mdpi.com/2079-6382/11/9/1232.
    10.3390/antibiotics11091232
  7. Adriana Guerreiro; Mariana A. Andrade; Carina Menezes; Fernanda Vilarinho; Elsa Dias. "Antioxidant and Cytoprotective Properties of Cyanobacteria: Potential for Biotechnological Applications". Toxins (2020): https://www.mdpi.com/2072-6651/12/9/548.
    10.3390/toxins12090548
  8. Menezes, Carina; Valério, Elisabete; Botelho, Maria João; Dias, Elsa. "Isolation and Characterization of Cylindrospermopsis raciborskii Strains from Finished Drinking Water". Toxins 12 1 (2020): 40. http://dx.doi.org/10.3390/toxins12010040.
    10.3390/toxins12010040
  9. Dias, Elsa; Oliveira, Micaela; Manageiro, Vera; Vasconcelos, Vitor; Caniça, Manuela. "Deciphering the role of cyanobacteria in water resistome: Hypothesis justifying the antibiotic resistance (phenotype and genotype) in Planktothrix genus". Science of The Total Environment 652 (2019): 447-454. http://dx.doi.org/10.1016/j.scitotenv.2018.10.167.
    10.1016/j.scitotenv.2018.10.167
  10. Dias, Elsa. "Risk Levels of Toxic Cyanobacteria in Portuguese Recreational Freshwaters". Toxins (2017): http://www.mdpi.com/2072-6651/9/10/327.
    10.3390/toxins9100327
  11. Caniça, Manuela; Manageiro, Vera; Jones-Dias, Daniela; Clemente, Lurdes; Gomes-Neves, Eduarda; Poeta, Patrícia; Dias, Elsa; Ferreira, Eugénia. "Current perspectives on the dynamics of antibiotic resistance in different reservoirs". Research in Microbiology 166 7 (2015): 594-600. http://dx.doi.org/10.1016/j.resmic.2015.07.009.
    10.1016/j.resmic.2015.07.009
  12. Dias, Elsa; Oliveira, Micaela; Jones-Dias, Daniela; Vasconcelos, Vitor; Ferreira, Eugénia; Manageiro, Vera; Caniça, Manuela. "Assessing the antibiotic susceptibility of freshwater Cyanobacteria spp.". Frontiers in Microbiology 6 (2015): http://dx.doi.org/10.3389/fmicb.2015.00799.
    10.3389/fmicb.2015.00799
  13. Dias, E.; Paulino, S.; Pereira, P.. "Cyanotoxins: From poisoning to healing-a possible pathway?". Limnetica 34 1 (2015): 159-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941006487&partnerID=MN8TOARS.
  14. Dias, Elsa; Louro, Henriqueta; Pinto, Miguel; Santos, Telma; Antunes, Susana; Pereira, Paulo; Silva, Maria João. "Genotoxicity of Microcystin-LR inIn VitroandIn VivoExperimental Models". BioMed Research International 2014 (2014): 1-9. http://dx.doi.org/10.1155/2014/949521.
    Published • 10.1155/2014/949521
  15. Menezes, C.; Alverca, E.; Dias, E.; Sam-Bento, F.; Pereira, P.. "Involvement of endoplasmic reticulum and autophagy in microcystin-LR toxicity in Vero-E6 and HepG2 cell lines". Toxicology in Vitro 27 1 (2013): 138-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869431500&partnerID=MN8TOARS.
    10.1016/j.tiv.2012.09.009
  16. Dias, E.; Matos, P.; Pereira, P.; Batoréu, M.C.C.; Silva, M.J.; Jordan, P.. "Microcystin-LR activates the ERK1/2 kinases and stimulates the proliferation of the monkey kidney-derived cell line Vero-E6". Toxicology in Vitro 24 6 (2010): 1689-1695. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956172500&partnerID=MN8TOARS.
    10.1016/j.tiv.2010.05.018
  17. Paulino, S.; Sam-Bento, F.; Churro, C.; Alverca, E.; Dias, E.; Valério, E.; Pereira, P.. "The Estela Sousa e Silva Algal Culture Collection: a resource of biological and toxicological interest". Hydrobiologia (2009): 1-4. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350524210&partnerID=MN8TOARS.
    10.1007/s10750-009-9977-4
  18. Alverca, E.; Andrade, M.; Dias, E.; Sam Bento, F.; Batoréu, M.C.C.; Jordan, P.; Silva, M.J.; Pereira, P.. "Morphological and ultrastructural effects of microcystin-LR from Microcystis aeruginosa extract on a kidney cell line". Toxicon 54 3 (2009): 283-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649414226&partnerID=MN8TOARS.
    10.1016/j.toxicon.2009.04.014
  19. Dias, E.; Andrade, M.; Alverca, E.; Pereira, P.; Batoréu, M.C.C.; Jordan, P.; Silva, M.J.. "Comparative study of the cytotoxic effect of microcistin-LR and purified extracts from Microcystis aeruginosa on a kidney cell line". Toxicon 53 5 (2009): 487-495. http://www.scopus.com/inward/record.url?eid=2-s2.0-61449170919&partnerID=MN8TOARS.
    10.1016/j.toxicon.2009.01.029
  20. Lawrence, J.F.; Niedzwiadek, B.; Menard, C.; De Rojas Astudillo, L.; Biré, R.; Burdaspal, P.A.; Ceredi, A.; et al. "Quantitative determination of paralytic shellfish poisoning toxins in shellfish using prechromatographic oxidation and liquid chromatography with fluorescence detection: Collaborative study". Journal of AOAC International 88 6 (2005): 1714-1732. http://www.scopus.com/inward/record.url?eid=2-s2.0-30644458552&partnerID=MN8TOARS.
  21. Batoréu, M.C.C.; Dias, E.; Pereira, P.; Franca, S.. "Risk of human exposure to paralytic toxins of algal origin". Environmental Toxicology and Pharmacology 19 3 (2005): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044413726&partnerID=MN8TOARS.
    10.1016/j.etap.2004.12.002
  22. Nogueira, I.C.G.; Pereira, P.; Dias, E.; Pflugmacher, S.; Wiegand, C.; Franca, S.; Vasconcelos, V.M.. "Accumulation of paralytic shellfish toxins (PST) from the cyanobacterium Aphanizomenon issatschenkoi by the cladoceran Daphnia magna". Toxicon 44 7 (2004): 773-780. http://www.scopus.com/inward/record.url?eid=2-s2.0-6944239771&partnerID=MN8TOARS.
    10.1016/j.toxicon.2004.08.006
  23. Pereira, P.; Li, R.; Carmichael, W.W.; Dias, E.; Franca, S.. "Taxonomy and production of paralytic shellfish toxins by the freshwater cyanobacterium Aphanizomenon gracile LMECYA40". European Journal of Phycology 39 4 (2004): 361-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144308891&partnerID=MN8TOARS.
    10.1080/09670260410001714723
  24. Pereira, P.; Dias, E.; Franca, S.; Pereira, E.; Carolino, M.; Vasconcelos, V.. "Accumulation and depuration of cyanobacterial paralytic shellfish toxins by the freshwater mussel Anodonta cygnea". Aquatic Toxicology 68 4 (2004): 339-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642567509&partnerID=MN8TOARS.
    10.1016/j.aquatox.2004.04.001
  25. Lawrence, J.F.; Niedzwiadek, B.; Menard, C.; Biré, R.; Burdaspal, P.A.; Ceredi, A.; Davis, B.; et al. "Quantitative Determination of Paralytic Shellfish Poisoning Toxins in Shellfish Using Prechromatographic Oxidation and Liquid Chromatography with Fluorescence detection: Interlaboratory Study". Journal of AOAC International 87 1 (2004): 83-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144357360&partnerID=MN8TOARS.
  26. Dias, E.; Pereira, P.; Franca, S.. "Production of paralytic shellfish toxins by Aphanizomenon sp. Lmecya 31 (Cyanobacteria)". Journal of Phycology 38 4 (2002): 705-712. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036692426&partnerID=MN8TOARS.
    10.1046/j.1529-8817.2002.01146.x
  27. Cruz, H.J.; Conradt, H.S.; Dunker, R.; Peixoto, C.M.; Cunha, A.E.; Thomaz, M.; Burger, C.; et al. "Process development of a recombinant antibody/interleukin-2 fusion protein expressed in protein-free medium by BHK cells". Journal of Biotechnology 96 2 (2002): 169-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-18444382663&partnerID=MN8TOARS.
    10.1016/S0168-1656(02)00028-7
  28. Cruz, H.J.; Peixoto, C.M.; Nimtz, M.; Alves, P.M.; Dias, E.M.; Moreira, J.L.; Carrondo, M.J.T.. "Metabolic shifts do not influence the glycosylation patterns of a recombinant fusion protein expressed in BHK cells". Biotechnology and Bioengineering 69 2 (2000): 129-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034691774&partnerID=MN8TOARS.
  29. Cruz, H.J.; Dias, E.M.; Peixoto, C.M.; Moreira, J.L.; Carrondo, M.J.T.. "Product quality of a recombinant fusion protein expressed in immobilised baby hamster kidney cells grown in protein-free medium". Biotechnology Letters 22 8 (2000): 677-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034059758&partnerID=MN8TOARS.
    10.1023/A:1005631602517
  30. Burger, C.; Carrondo, M.J.T.; Cruz, H.; Cuffe, M.; Dias, E.; Griffiths, J.B.; Hayes, K.; et al. "An integrated strategy for the process development of a recombinant antibody-cytokine fusion protein expressed in BHK cells". Applied Microbiology and Biotechnology 52 3 (1999): 345-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032884613&partnerID=MN8TOARS.
    10.1007/s002530051530
  31. Cruz, H.J.; Moreira, J.L.; Stacey, G.; Dias, E.M.; Hayes, K.; Looby, D.; Griffiths, B.; Carrondo, M.J.T.. "Adaptation of BHK cells producing a recombinant protein to serum-free media and protein-free medium". Cytotechnology 26 1 (1998): 59-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031910446&partnerID=MN8TOARS.
    10.1023/A:1007951813755
  32. Cruz, H.J.; Dias, E.M.; Moreira, J.L.; Carrondo, M.J.T.. "Cell-dislodging methods under serum-free conditions". Applied Microbiology and Biotechnology 47 5 (1997): 482-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030990534&partnerID=MN8TOARS.
    10.1007/s002530050960
Magazine article
  1. Elsa Dias; Rosado, Tânia; Menezes, Carina. "Elsa Dias, Tânia Rosado, Carina Menezes. 2021. Novos valores-guia da Organização Mundial de Saúde para cianotoxinas em águas para consumo humano e balneares. Boletim Epidemiológico Observações. 10(30):5-14", Boletim Epidemiológico Observações., 2021, https://repositorio.insa.pt/handle/10400.18/7778..
  2. "Rita Martins, Carlos Pinto. Elsa Dias; Tânia Rosado; Carina Menezes. 2021. Intoxicação animal por cianobactérias: um alerta para a saúde pública? Boletim Epidemiológico Observações, 10(29), 18-23021", Boletim Epidemiológico Observações., 2021, https://repositorio.insa.pt/handle/10400.18/7759..
  3. Dias, Elsa; Susana Franca. "Intoxicações por consumo de bivalves contaminados por biotoxinas: Dados históricos na Lagoa de Óbidos – Os casos de intoxicação por neurotoxinas.", Publicações a convite do Centro de Interpretação da Lagoa de Óbidos., 2020, https://www.lagoadeobidos.pt/files/ElectroModules/DynamoCms/Models/Media/Media/131/629f762aa3402.pdf.
  4. "Carina Menezes, Olga Martins, Elsa Dias. 2016. Tratamento de águas para consumo humano: um episódio de sobrevivência de cianobactérias. Observações_Boletim Epidemiológico do Instituto Nacional de Saúde Dr. Ricardo Jorge 8: 56-28.", 2016, http://repositorio.insa.pt/bitstream/10400.18/4135/3/observacoesNEspecia8-2016_artigo14.pdf.
  5. Churro, C.; Dias, Elsa; Paulino, S.; Pereira, P.. "Catarina Churro, Elsa Dias, Sérgio Paulino, Elsa Alverca, Paulo Pereira. 2013. Importância da Monitorização de Cianobactérias em albufeiras Portuguesas.. Observações_Boletim Epidemiológico do Instituto Nacional de Saúde Dr. Ricardo Jorge, 4, 18-20.", Observações_Boletim Epidemiológico do Instituto Nacional de Saúde Dr. Ricardo Jorge , 2013, http://www2.insa.pt/sites/INSA/Portugues/PublicacoesRepositorio/Documents/observa%C3%A7%C3%B5es42013_artigo6.pdf.
Report
  1. Dias, E.. 2022. Relatório Final do projeto “Exploring the aquatic resistome (ExplorAR)”, Ref. PTDC/BIA-BMA/31451/2017.
  2. Dias, Elsa. 2019. Distribuição e dinâmica de ocorrências de cianobactérias e compostos associados na Albufeira do Roxo.. http://hdl.handle.net/10400.18/6345.
Thesis / Dissertation
  1. Dias, Elsa. "Avaliação do potencial cancerigénico de microcistinas (cianotoxinas).". PhD, Universidade de Lisboa Faculdade de Farmácia, 2009. http://repositorio.insa.pt/handle/10400.18/722.
  2. Dias, Elsa. "Caracterização da produção de toxinas PSP numa estirpe de Aphanizomenon issatschenkoii (cianobactéria). Estudo da re-ocorrência de toxinas PSP na albufeira de Montargil. Implicações para a saúde pública.". Master, 2001.
  3. Dias, Elsa. "Produção de uma proteína recombinante em culturas de células animais". Degree, Universidade de Lisboa Faculdade de Ciências, 1996.