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Alexandre da Costa Oliveira completed the Master's degree in Chemistry in 2016 by the Faculty of Science and Technology at the University of Coimbra with a final degree mark of 18/20 and a bachelor's degree in Medicinal Chemistry in 2013 by the Faculty of Science and Technology at the University of Coimbra with a final degree mark of 16/20. Attends the Ph.D. in Chemistry with a specialization in Biological Chemistry by the Faculty of Science and Technology at the University of Coimbra with a Ph.D. grant supported by the Fundação para Ciência e Tecnhologia, Portugal.
Identification

Personal identification

Full name
Alexandre da Costa Oliveira

Citation names

  • Oliveira, Alexandre C.

Author identifiers

Ciência ID
4F17-5D8D-022A
ORCID iD
0000-0001-7920-7773

Email addresses

  • ac_oliveira10@hotmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French (Mother tongue)
Education
Degree Classification
2017/09 - 2026
Ongoing
 Chemistry (Doctorate)
Major in Biological Chemistry
Faculty of Science and Technology at the University of Coimbra, Portugal
"A Rational Approach to the Enhancement of Brain Availability of Imaging Probes" (THESIS/DISSERTATION)
2019/09/02 - 2019/09/12
Concluded
 Summer School in Computational Biology- From molecules to tissues (Others)
Universidade de Coimbra, Portugal
2013/09/15 - 2016/02/26
Concluded
 Chemistry (Master's Degree)
Major in Specialization in Advanced and Industrial Chemistry
Faculty of Science and Technology at the University of Coimbra, Portugal
"Caracterização Físico-Química de complexos de iões de lantanídeos conjugados com PiB e sua interacção com agregados Aß(1 40)" (THESIS/DISSERTATION)
 18
2015/06/15 - 2015/06/19
Concluded
 NMR and Modeling Methods for Protein Interactions and Drug Design (Others)
Universidade de Coimbra, Portugal
2014 - 2015
Concluded
 English Language Course, upper Intermediate Level I (Others)
Universidade de Coimbra, Portugal
2014/09/30 - 2014/10/03
Concluded
 NMR Basics: Theory, Processing and Analysis (Others)
Universidade de Coimbra, Portugal
2013 - 2014
Concluded
 English Language Course, Intermediate Level I (Others)
Universidade de Coimbra, Portugal
2013 - 2014
Concluded
 English Language Course, Intermediate Level II (Others)
Universidade de Coimbra, Portugal
2010 - 2013
Concluded
 Medicinal Chemistry (Licenciate Degree)
Faculty of Science and Technology at the University of Coimbra, Portugal
"Agregação dos Péptidos ß Amilóides 1-28 e 1-40 e sua Associação com a Sonda AML3 Monitorizadas por Dicroísmo Circular e Fluorescência da sonda Tioflavina-T" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution		 Employer
2017 - Current Researcher (Research) PhD grant supported by the Fundação para Ciência e Tecnhologia, Portugal (SFRH/BD/120934/2016), Portugal
Coimbra Chemistry Center at the department of Chemistry of the Faculty of Science and Technology at the University of Coimbra, Portugal

Others

Category
Host institution		 Employer
2021/06/30 - 2021/10/31 Fulbright Scholarship Program at the Prof. Gregory Voth group University of Chicago Department of Chemistry, United States
2015/02/15 - 2015/04/15 Visiting Young Scientist (STSM-COST) in Metal Complexes for Biomedical Applications Centre de Biophysique Moléculaire, France
Centre de Biophysique Moléculaire, France
Projects

Grant

Designation Funders
2025/09 - 2026/08 Coimbra Chemistry Centre
UID/00313/2025
10.54499/UID/00313/2025
Researcher
Coimbra Chemistry Center at the department of Chemistry of the Faculty of Science and Technology at the University of Coimbra, Portugal
2022/12 - 2023/04 Coimbra Chemistry Centre
UIDB/00313/2020
10.54499/UIDB/00313/2020
Researcher
Coimbra Chemistry Center at the department of Chemistry of the Faculty of Science and Technology at the University of Coimbra, Portugal
2017/09 - 2021/10 A Rational Approach to the Enhancement of Brain Availability of Imaging Probes
FRH/BD/120934/2016
PhD Student Fellow
University of Coimbra, Portugal

Other

Designation Funders
2021/01/01 - 2021/12/31 In Silico Optimization of Brain Imaging Probes with Enhanced Permeation
CPCA/A2/7181/2020
Researcher
Fundacao para a Computacao Cientifica Nacional
Concluded
Outputs

Publications

Conference poster
  1. Alexandre C. Oliveira; Hugo A. L. Filipe; Carlos F.G.C. Geraldes; Gregory A. Voth; Maria João Moreno; Luis M. S. Loura. "Interaction Of MRI Contrast Agent [GD(DOTA)]- with Lipid Membranes: A Molecular Dynamics Study". Paper presented in 4th Meeting of Young Biophysicists’, Covilhã, Portugal, 2024.
  2. Alexandre C. Oliveira; Hugo A. L. Filipe; Luís M. S. Loura. "Flourescent Probes cis- and trans-Parinaric Acids in Fluid and Gel Lipid Bilayers: A Molecular Dynamics Study". Paper presented in 4th Meeting of Young Biophysicists’, Covilhã, Portugal, 2024.
  3. Alexandre C. Oliveira; Hugo A. L. Filipe; Rui Sun; Gregory A. Voth; Carlos F. G. C. Geraldes; Maria João Moreno; Luís M. S. Loura. "Interaction of contrast agents with biomembranes". Paper presented in 8th International Iberian Biophysics Congress, Bilbao, Spain, 2022.
  4. Alexandre C. Oliveira; Hugo A. L. Filipe; Armindo Salvador; Rui Sun; Gregory A. Voth; Carlos F. G. C. Geraldes; Maria João Moreno; Luís M. S. Loura. "Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers". Paper presented in 2nd Portuguese Young Biophysicists’ Meeting, Aveiro, Portugal, 2022.
  5. Alexandre C. Oliveira; Hugo A. L. Filipe; Armindo Salvador; Rui Sun; Gregory A. Voth; Carlos F. G. C. Geraldes; Maria João Moreno; Luís M. S. Loura. "Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers". Paper presented in VIII Encontro de Jovens Investigadores de Biologia Computacional Estrutural, Coimbra, Portugal, 2021.
  6. Alexandre C. Oliveira; Hugo A. L. Filipe; Armindo Salvador; Rui Sun; Gregory A. Voth; Carlos F. G. C. Geraldes; Maria João Moreno; Luís M. S. Loura. "Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers". Paper presented in Coimbra Chemistry Center Day 2021, Coimbra, Portugal, 2021.
  7. Rui MS Santos; Alexandre C. Oliveira; Hugo AL Filipe; Maria João Moreno; Luís MS Loura. "Interaction of the antibiotic Rifampicin with lipid membranes: molecular dynamics simulations". Paper presented in 7th International Iberian Biophysics Congress, Coimbra, Portugal, 2021.
  8. Joana RM Brás; Alexandre C. Oliveira; Margarida Castro; Carlos FGC Geraldes; Marta Piñero; Maria João Moreno. "Synthesis of Lipophilic Gd-DOTA derivatives for use as Contrast Agents in MRI - Characterization of their Interaction with POPC Bilayers". Paper presented in 7th International Iberian Biophysics Congress, Coimbra, Portugal, 2021.
  9. Alexandre C. Oliveira; Jean-François Morfin; Éva Tóth; Telma C. Costa; Licínia L.G. Justino; Hugh D. Burrows; Carlos F.G.C. Geraldes. "Lanthanide DO3A-type complexes conjugated to Pittsburgh compound B as optical and MRI probes for targeting Aß amyloid aggregates involved in Alzheimer’s disease". Paper presented in 5th International Iberian Biophysics Congress, Porto, Portugal, 2016.
  10. C.F.G.C. Geraldes; A.F. Martins; Alexandre C. Oliveira; D.M. Dias; J.F. Morfin; S. Lacerda; D. Laurents; E. Toth. "Interaction of metal complexes conjugated to Pittsburg compound B with the monomeric and aggregated Abeta1-40 peptide in solution by NMR". Paper presented in EUROMAR 2015, Prague, Czech Republic, 2015.
Journal article
  1. Loura, Luís M.S; Cordeiro, Margarida M.; Oliveira, Alexandre C.; Moreno, Maria João. "The dual nature of molecules: amphiphilicity as a missing descriptor in drug design". (2027):
    Submitted
  2. Moreno, Maria João; Cordeiro, Margarida M.; Filipe, Hugo A. L.; Oliveira, Alexandre C.; Pires, Cristiana L.; Ramos, Cristiana V.; Samelo, Jaime; Martins, Jorge; Loura, Luís M. S.. "Quantifying Small-Molecule Association with Lipid Membranes: Methods, Models, and Limitations". Membranes 16 7 (2026): 218. https://doi.org/10.3390/membranes16070218.
    10.3390/membranes16070218
  3. Cordeiro, Margarida M.; Oliveira, Alexandre C.; Abreu, Paulo E.; Arnaut, Luis G.; Moreno, Maria João; Loura, Luís M. S.. "Passive Transport across Cell Membranes beyond the Overton Rule: Insights from Solute Exchange in Vesicles and Molecular Dynamics of Atropisomers". ACS Applied Materials & Interfaces 17 16 (2025): 23575-23587. https://doi.org/10.1021/acsami.4c22459.
    10.1021/acsami.4c22459
  4. Santos, Rui M. S.; Samelo, Jaime; Oliveira, Alexandre C.; Cordeiro, Margarida M.; Mora, Maria Julia; Granero, Gladys E.; Filipe, Hugo A. L.; Loura, Luís M. S.; Moreno, Maria João. "Interaction of the Antibiotic Rifampicin with Lipid Membranes". Biomolecules 15 3 (2025): 320. https://doi.org/10.3390/biom15030320.
    10.3390/biom15030320
  5. Oliveira, Alexandre C.; Filipe, Hugo A. L.; Geraldes, Carlos F.G.C.; Voth, Gregory A.; Moreno, Maria João; Loura, Luís M. S.. Corresponding author: Oliveira, Alexandre C.. "Interaction of MRI Contrast Agent [Gd(DOTA)]<sup>-</sup> with Lipid Membranes: A Molecular Dynamics Study". Inorganic Chemistry 63 24 (2024): 10897-10914. http://dx.doi.org/10.1021/acs.inorgchem.4c00972.
    10.1021/acs.inorgchem.4c00972
  6. Oliveira, Alexandre C.; Filipe, Hugo A. L.; Loura, Luís M. S.. "Fluorescent Probes cis- and trans-Parinaric Acids in Fluid and Gel Lipid Bilayers: A Molecular Dynamics Study". Molecules 28 5 (2023): 2241. https://doi.org/10.3390/molecules28052241.
    10.3390/molecules28052241
  7. Oliveira, Alexandre C.; Filipe, Hugo A. L.; Ramalho, João P. Prates; Salvador, Armindo; Geraldes, Carlos F. G. C.; Moreno, Maria João; Loura, Luís M. S.. "Modeling Gd<sup>3+</sup> Complexes for Molecular Dynamics Simulations: Toward a Rational Optimization of MRI Contrast Agents". Inorganic Chemistry 61 30 (2022): 11837-11858. http://dx.doi.org/10.1021/acs.inorgchem.2c01597.
    10.1021/acs.inorgchem.2c01597
  8. Magalhães, Nisa; Simões, Guilherme M.; Ramos, Cristiana; Samelo, Jaime; Oliveira, Alexandre C.; Filipe, Hugo A. L.; Ramalho, João P. Prates; Moreno, Maria João; Loura, Luís M. S.. "Interactions between Rhodamine Dyes and Model Membrane Systems-Insights from Molecular Dynamics Simulations". Molecules 27 4 (2022): 1420. http://dx.doi.org/10.3390/molecules27041420.
    10.3390/molecules27041420
  9. Majdoub, Saida; Garda, Zoltán; Oliveira, Alexandre C.; Relich, Inga; Pallier, Agnès; Lacerda, Sara; Hureau, Christelle; et al. "Concentration-Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aß and Amylin**". Chemistry – A European Journal 27 6 (2020): 2009-2020. https://doi.org/10.1002/chem.202004000.
    10.1002/chem.202004000
  10. Majdoub, Saida; Garda, Zoltán; Oliveira, Alexandre C.; Relich, Inga; Pallier, Agnès; Lacerda, Sara; Hureau, Christelle; et al. "Concentration-Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aß and Amylin**". Chemistry – A European Journal 27 6 (2020): 1864-1864. http://dx.doi.org/10.1002/chem.202004825.
    10.1002/chem.202004825
  11. Oliveira, Alexandre C.; Costa, Telma; Justino, Licinia L. G.; Fausto, Rui; Morfin, Jean-François; Tóth, Éva; Geraldes, Carlos F. G. C.; Burrows, Hugh D.. "Photophysical studies on lanthanide(iii) chelates conjugated to Pittsburgh compound B as luminescent probes targeted to Aß amyloid aggregates". Photochemical & Photobiological Sciences 19 11 (2020): 1522-1537. https://doi.org/10.1039/d0pp00214c.
    10.1039/d0pp00214c
  12. Martins, André F.; Oliveira, Alexandre C.; Morfin, Jean-François; Laurents, Douglas V.; Tóth, Éva; Geraldes, Carlos F. G. C.. "Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aß amyloid aggregates". JBIC Journal of Biological Inorganic Chemistry 21 1 (2015): 83-99. http://dx.doi.org/10.1007/s00775-015-1316-9.
    10.1007/s00775-015-1316-9
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/06/15 Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers 7th International Iberian Biophysics Congress
(Coimbra, Portugal)

Event organisation

Event name
Type of event (Role)		 Institution / Organization
2024/09/03 - 2024/09/13 2024 Summer School in Computational Biology (2024/09/03 - 2024/09/13)
Workshop (Other)
 Universidade de Coimbra, Portugal
2023/06/01 - 2023/06/02 BIOPHYSICS FESTIVAL 3rd Meeting of Young Biophysicists (2023/06/01 - 2023/06/02)
Conference (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/05/30 - 2018/05/30 mini-Symposium -The life of Inorganic Chemistry: from molecules to imaging. (2018/05/30 - 2018/05/30)
Symposium (Member of the Organising Committee)
 Department of Chemistry at University of Coimbra, Portugal
2013/03/22 - 2013/03/24 1st National Meeting of Chemistry Students (2013/03/22 - 2013/03/24)
Meeting (Member of the Organising Committee)
 Chemistry Students of the Faculty of Science and Technology, University of Coimbra, Portugal

Association member

Society Organization name Role
2016 - Current Sociedade Portuguesa de Bioquímica (SPB)
2016 - Current Sociedade Portuguesa de Biofísica (SPBf)
2012 - 2013 Chemistry Student’s Association of the Chemistry Department at the University of Coimbra (NEQ/AAC) Vice-Chairman of the Plenary
2011 - 2013 Academic Association of Coimbra at the University of Coimbra (AAC) Member of professional goals division

Interview (tv / radio show)

Program Topic
2021/10/14 - 2021/10/14 Podcast Molecular episódio 20
Distinctions

Other distinction

2024 Article selected for front page of Scientific Journal (doi: 10.1021/acs.inorgchem.4c00972)
2024 Article selected as featured article (doi: 10.1021/acs.inorgchem.4c00972)
2024 article selected as ACS editor's choice (doi: 10.1021/acs.inorgchem.4c00972)
2021 Article selected for front page of Scientific Journal: DOI: 10.1002/chem.202004000
2021 Article selected as hot paper (doi: 10.1002/chem.202004000)
2020 Article selected for front page of Scientific Journal: DOI: 10.1039/D0PP00214C