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Biochemistry MSc, proficient in the production, study and characterisation of structure and function of proteins. Skilled in protein expression, purification, crystallisation and biophysical analysis (molybdenum enzymes, azurin's and cytochrome's). Practiced at X-ray Crystallography (protein crystal preparation; structure determination, refinement and validation), SAXS (sample preparation; data processing; model generation), biophysical and spectroscopic techniques (MST, enzyme kinetics, TSA, fluorescence spectroscopy). Experience at working with ionic liquids and pharmaceutical ingredients, using DSC, ATR-FTIR, and controlled release techniques.
Identification

Personal identification

Full name
Filipa Sofia Silva Engrola

Citation names

  • Engrola, Filipa S. S.
  • Filipa S. S. Engrola

Author identifiers

Ciência ID
4219-13FE-6152
ORCID iD
0000-0002-7066-5126

Email addresses

  • f.engrola@campus.fct.unl.pt (Professional)
Education
Degree Classification
2017/09 - 2019/11
Concluded
Bioquímica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Bacterial arsenite oxidation at the molecular level " (THESIS/DISSERTATION)
2014/09 - 2017/07
Concluded
Bioquímica (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Phase transformations and controlled delivery of an ionic liquid derived from Ibuprofen" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2020/05/01 - Current Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2018/09 - 2019/11 Research Trainee (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017/07/01 - 2017/07/31 Research Trainee (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2020 - Current BACTERIAL ABC-TYPE MULTITASK ENERGIZERS: ONE ATPASE FITS ALL?
PTDC/BIA-MIC/30696/2017
Research Fellow
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference poster
  1. Engrola, Filipa S. S.; Correia, Márcia; Joanne M. Santini; Cameron Watson; Romão, Maria; Santos-Silva, Teresa. "New insights on the catalytic mechanism of arsenite oxidase". Paper presented in In situ Structural Biology: From Cryo-EM to Integrative Modelling, 2020.
  2. Engrola, Filipa; Romão, Maria; Correia, Márcia; Joanne M. Santini; Cameron Watson; Teresa Sacadura Santos-Silva. "Arsenite oxidase: Structural and functional insigths on the electron transfer pathway". Paper presented in Instruct Biennial Structural Biology Conference: Deeper into the Cell, 2019.
Thesis / Dissertation
  1. Engrola, Filipa Sofia Silva. "Bacterial arsenite oxidation at the molecular level". Master, Universidade Nova de Lisboa, 2019. http://hdl.handle.net/10362/89008.
Working paper
  1. Engrola, Filipa S. S.; Márcia A. S. Correia; Cameron Watson; Joanne M. Santini; Maria Joao Romao; Teresa Sacadura Santos-Silva. 2020. "The complex of Arsenite Oxidase with antimonite oxyanions and insights into the catalytic mechanism". Working Paper.

Artistic / Performance

Video recording
  1. Engrola, Filipa S. S.; Andreia C. P. Fernandes. 2019. VOX POP - O que a ciência tem para nos dar.
  2. Engrola, Filipa S. S.; Luís Miguel Mariano Domingues Filipe. 2019. RockTheElements - The Dark Side of The Periodic Table.
  3. Engrola, Filipa S. S.; Luís Miguel Mariano Domingues Filipe; Andreia Lamy. 2016. Prémios Nobel- VOX POP.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07 Arsenite oxidase: from the substrate analogue to the electron acceptors – Structural and functional insights The 8th Meeting of Portuguese Synchrotron Radiation Users (ENURS 2019)
Faculty of Sciences of University of Porto (FCUP) (Porto, Portugal)
2019/03 Bacterial arsenite oxidation at the molecular level – Protein crystallography and Small Angle X-ray Scattering VII Encontro Nacional de Estudantes de Química 2019 / "VII National Meeting of Chemistry Students" (ENEQUI '19)
NOVA School of Science and Technology (FCT NOVA) (Caparica, Portugal)
2019/02/15 Bacterial arsenite oxidation at the molecular level – Protein crystallography and Small Angle X-ray Scattering Jornadas Intercalares das Dissertações Anuais dos Mestrados do Departamento de Química e do Departamento de Ciências da Vida (JIM)
Universidade Nova de Lisboa (Portugal)
2018/11/28 Amor à Primeira Vista - as hormonas / Love at first sight - the hormones World's Biggest Chemistry Class Cascais 2018/ A Maior Aula de Química do Mundo Cascais 2018
CASCAIS 2018 - CAPITAL EUROPEIA DA JUVENTUDE (Cascais, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019/04 - Current Volunteer in hosting and organizing an event at EXPO-FCT 2019. This annual event is destined to present the faculty and its educational offer, which aims to facilitate the choice of higher education by young pre-university students, through demonstrations and activities in science and engineer areas. (2019/04/23)
Exhibition (Co-organisor)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/09/01 - Current Founding member of the “Núcleo de estudantes de Bioquímica FCT-UNL (NuBioq)” (2017/09/01)
Exhibition (Member of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/11/25 - Current This lecture aimed to clarify how it is to work within the scientific community, tips on how to build a solid career and how to deal with the struggles. Pedro Viana Baptista, Professor at FCT-NOVA and Helena Santos, Professor at ITQB were the invited guests. (2016/11/25)
Seminar (President of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/03 - 2019/03 Laboratory experiments planning for primary school students. (2019/03 - 2019/03)
Exhibition (Member of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Agrupamento de Escolas Professor Armando de Lucena, Portugal
2016/06 - 2017/06 Former Director "área educativa do núcleo de estudantes de Bioquímica FCT-NOVA". Charity, science communication or mentoring are some of the activities developed to help the student body. (2016/06)
Exhibition (President of the Organising Committee)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2019/07/28 - Current Researchers, users of synchrotron radiaton from any infrastructure and research field present their recent works both by oral and poster communications.
Conference
The 8TH Meeting of Portuguese Synchrotron Radiation Users (ENURS 2019)
Universidade do Porto Faculdade de Ciências, Portugal
2018/11/28 - Current Key speaker at the World Guinness Record "World's Biggest Chemistry Class Cascais 2018/A Maior Aula de Química do Mundo Cascais 2018". A science communication event that took place in Cascais, where 1440 elementary school students learned about chemistry.
Seminar
World's Biggest Chemistry Class Cascais 2018/ A Maior Aula de Química do Mundo Cascais 2018
2020/08/09 - 2020/10/09 This annual meeting gathers synchrotron users, at a scientific event that includes presentations in plenary, poster, and parallel sessions. Participants are able to learn about current/future facility capabilities and the latest user research as well as to discuss science with colleagues from academia, research laboratories, and industry worldwide.
Conference
2020 Virtual SSRL/LCLS Users' Meeting
Stanford Synchrotron Radiation Lightsource, United States
2020/05/05 - 2020/06/02 This online course aims at young biochemists/biophysicists and researchers active in related structural methods with little or no experience in solution scattering. The course covered basics of SAXS, instrumentation, sample preparation, modelling techniques and complementary use with other methods.
Workshop
Solution Scattering from Biological Macromolecules
European Molecular Biology Laboratory Hamburg, Germany
2020/02/20 - 2020/02/20 Practical and theoretical insights into ChemDraw and Reaxys software.
Workshop
Chemistry Software Workshop: ChemDraw and Reaxys
Universidade Nova de Lisboa, Portugal
2019/11 - 2019/11 Protein purification workshop
Workshop
Protein purification workshop: Technical tips & tricks Column replacement day
GE Healthcare Healthcare Systems, Netherlands
2019/06 - 2019/06 “Rock the elements – The challenge” was an event where scientists, students and the general public were invited to produce a science communication video, aiming to disseminate scientific knowledge. 3rd place in “Rock The elements – the challange”
Universidade Nova de Lisboa, Portugal
2019/05/22 - 2019/05/24 International Structural Biology conference Instruct Biennial Structural Biology Conference: Deeper into the Cell
Instruct-ERIC, Spain
2019/05/22 - 2019/05/22 Women in Science Workshop - Instruct-ERIC. Practical advice from leading women scientists in industry and academia and discussions about how Instruct-ERIC can support our community to progress in their careers.
Workshop
Women in Science Workshop - Instruct-ERIC
INSTRUCT-ULTRA, Spain
2019/03/22 - 2019/03/25 At the National Meeting of Chemistry Students (in Portuguese, Encontro Nacional de Estudantes de Química) all chemistry students can attend presentations of national and international speakers, as well as participate in workshops.
Conference
VII National Chemistry Students Meeting (ENEQUI '19)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/03 - 2019/03 Leacture and laboratory activity to middle school students about the importance of the elements of the periodic table in our lives.
Exhibition
Escola Básica e Secundária Professor Armando de Lucena, Portugal
2018/09/28 - 2018/09/28 The UCIBIO Annual Meeting counts with 3 keynote speakers, invited speakers from industry, Presentations and Flash Presentations on the Thematic Lines, and Poster Sessions.
Meeting
UCIBIO anual meeting 2018
Universidade Nova de Lisboa, Portugal
2018/03 - 2018/03 International science communication contest, sponsored by the British Council and integrated in the National Geographic Summit.
Exhibition
Fame LAb
British Council Portugal, Portugal
2017/07/24 - 2017/07/25 Supramolecular Chemistry Workshop. 1) Basic principles of supramolecular chemistry and molecular recognition. 2) Practical Class: Determination of an association constant of an inclusion complex. 3) Molecular recognition of neutral and ionic molecules - case studies.
Workshop
Supramolecular Chemistry Workshop
Universidade Nova de Lisboa, Portugal
2017/07 - 2017/07 Summer internship where students integrate a research team at IST and work in a project and learn about the workings of the institute, how to develop their ideas and do a presentation at the end.
Workshop
Técnico Summer Internships 2017
Universidade de Lisboa Instituto Superior Técnico, Portugal

Mentoring / Tutoring

Topic Student name
2019/10 - 2019/10 Support in the supervision of a MSc Student in the Biomolecular Techniques subject Marlene Cunha
2019/10 - 2019/10 Support in the supervision of a MSc Student in the Biomolecular Techniques course Kleyde Delgado
2019/04 - 2019/04 Suport in the supervion of a BSc Student during a laboratory internship Rita Jesus
Distinctions

Award

2020 EMBL Workshop fellowship
European Molecular Biology Laboratory, France
2019 Instruct-ERIC Women in Science fellowship award
INSTRUCT-ULTRA, Spain
2019 Best presentation at "Jornadas Intercalares dos mestrados do Departamento de Química e Ciências da Vida 2018/2019"
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 3rd place in “Rock The elements – the challange”

Title

2018 Semi-finalist at FameLAB contest
FameLab, Portugal