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Identification

Personal identification

Full name
Susana Maria Marinho de Bastos Pinto Pina dos Santos

Author identifiers

Ciência ID
321C-EBE3-FBB2

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
1991
Concluded
 Química (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
 Distinção e Louvor
1980
Concluded
 Química (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 Dezasseis valores
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
1991/12/06 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2018 Assistant Professor (University Teacher) Universidade de Lisboa Centro de Química e Bioquímica, Portugal
2007 - 2013 Assistant Professor (University Teacher) Universidade de Lisboa Centro de Química e Bioquímica, Portugal
1984/12 - 1991/12/05 Assistant (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
1981/05 - 1984/12 Assitente estagiária Universidade de Lisboa Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2010/04 - 2013/09 NIDOS-NEW IDO (indoleamine 2,3-dioxygenase) INIBITORS FROM MARINE SPONGES OF ERYLUS GENUS
grant.Provided by PTCRIS: 98053
 Fundação para a Ciência e a Tecnologia
2010/07 - 2013/06 “LUSOEXTRACT- Discovery of new natural compounds isolated from unique portuguese ecosystems presenting therapeutic properties
13107
 QREN-SI I&DT
2009/02 - 2012/08 From Design to Synthesis of New Anti-Tubercular Agents
grant.Provided by PTCRIS: 67933
 Fundação para a Ciência e a Tecnologia
2005/09 - 2007/06 Sulfenylcarbamates as cystein protease inhibitors: chemical and biochemical reactivity
grant.Provided by PTCRIS: 59328
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2017 - Current Em busca de novos derivados de isoniazida eficazes no combate à tuberculose multirresistente: uma abordagem integrada de química medicinal
PTDC/MED-QUI/29036/2017
Researcher
Outputs

Publications

Book chapter
  1. Santos, Susana. "How to Succeed in Marketing Marine Natural Products for Pharmaceutical, Cosmetics & Nutraceutical Markets". 2018.
  2. Santos, Susana. "Synthesis and structural characterization of an antitubercular isoniazid hydrazone". 2016.
  3. Santos, Susana. "Flavonoids from Ononis natrix L. subs. ramosissima"". 1995.
Edited book
  1. Santos, Susana. Natural Products in tNew Millennium: Prospects and Industrial Application. 2002.
Journal article
  1. Maria João Álvaro-Martins; Violeta Railean; Filomena Martins; Miguel Machuqueiro; Rita Pacheco; Susana Santos. "Synthesis and the In Vitro Evaluation of Antitumor Activity of Novel Thiobenzanilides". Molecules (2023): https://doi.org/10.3390/molecules28041877.
    10.3390/molecules28041877
  2. Júlio S; Ferro RA; Santos S; Alexandre A; Caldeira MJ; Franco J; Mário Barroso; Helena Gaspar. "Synthesis of emerging cathinones and validation of a SPE GC-MS method for their simultaneous quantification in blood.". Analytical and bioanalytical chemistry (2022): https://doi.org/10.1007/s00216-022-04440-6.
    10.1007/s00216-022-04440-6
  3. Joaquim Trigo Marquês; Catarina Frazão De Faria; Marina Reis; Diana Machado; Susana Santos; Maria da Soledade Santos; Miguel Viveiros; Filomena Martins; Rodrigo F. M. De Almeida. "In vitro Evaluation of Isoniazid Derivatives as Potential Agents Against Drug-Resistant Tuberculosis". Frontiers in Pharmacology 13 (2022): http://dx.doi.org/10.3389/fphar.2022.868545.
    10.3389/fphar.2022.868545
  4. Santos, Susana. "Designing new antitubercular isoniazid derivatives with improved reactivity and membrane trafficking abilities". Biomedicine & Pharmacotherapy 144 (2021): 112362-112362. http://dx.doi.org/10.1016/j.biopha.2021.112362.
    10.1016/j.biopha.2021.112362
  5. Jorge Soares; Vera Marisa Costa; Helena Gaspar; Susana Santos; Maria de Lourdes Bastos; Félix Carvalho; João Paulo Capela. "Adverse outcome pathways induced by 3,4-dimethylmethcathinone and 4-methylmethcathinone in differentiated human SH-SY5Y neuronal cells". Archives of Toxicology 94 7 (2020): 2481-2503. https://doi.org/10.1007/s00204-020-02761-y.
    10.1007/s00204-020-02761-y
  6. Antunes, Mónica; Sequeira, Margarida; de Caires Pereira, Mariana; Caldeira, Maria João; Santos, Susana; Franco, João; Barroso, Mário; Gaspar, Helena. "Determination of Selected Cathinones in Blood by Solid-Phase Extraction and GC–MS". Journal of Analytical Toxicology (2020): http://dx.doi.org/10.1093/jat/bkaa074.
    10.1093/jat/bkaa074
  7. Soares, Jorge; Costa, Vera Marisa; Gaspar, Helena; Santos, Susana; de Lourdes Bastos, Maria; Carvalho, Félix; Capela, João Paulo. "Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells". NeuroToxicology 75 (2019): 158-173. http://dx.doi.org/10.1016/j.neuro.2019.08.009.
    10.1016/j.neuro.2019.08.009
  8. Helena Gaspar; Soraia Bronze; Catarina Oliveira; Bruno L. Victor; Miguel Machuqueiro; Rita Pacheco; Maria João Caldeira; Susana Santos. "Proactive response to tackle the threat of emerging drugs: Synthesis and toxicity evaluation of new cathinones". Forensic Science International 290 (2018): 146-156. https://doi.org/10.1016/j.forsciint.2018.07.001.
    10.1016/j.forsciint.2018.07.001
  9. Soares, J.; Costa, V.M.; Bronze, S.; Gaspar, H.; Santos, S.; Bastos, M.L.; Carvalho, F.; Capela, J.. "Neurotoxicity of synthetic cathinones on differentiated SH-SY5Y human dopaminergic cells". Toxicology Letters 258 (2016): S181. http://dx.doi.org/10.1016/j.toxlet.2016.06.1671.
    10.1016/j.toxlet.2016.06.1671
  10. Santos, Susana. "Erylusamines: novel atypical glycolipids from Erylus cf deficients". Marine drugs (2016):
    10.3390/md14100179
  11. Santos, Susana. "Title: 4F-PBP (4-fluoro--pyrrolidinobutyrophenone), a new substance of abuse: Structural characterization and purity NMR profiling". Forensic Science International (2015):
    10.1016/j.forsciint.2015.05.003
  12. Santos, Susana. "Alkaline hydrolysis of tertiary N-(2-pyridyl) carbamates. Contradictory evidence between nucleophilic and general base catalysis". Reac Kinet Mech Cat (2015):
    10.1007/s11144-015-0867-7
  13. Santos, Susana. "Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity". European Journal of Medicinal Chemistry (2014):
    10.1016/j.ejmech.2014.04.077
  14. Santos, Susana. "Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success". Marine Drugs (2014):
    0.3390/md12021066
  15. Santos, Susana. "QSAR based design of new antitubercular compounds: improved isoniazid derivatives against multidrug-resistant TB". Current Pharmaceutical Design (2014):
    DOI: 10.2174/1381612819666131118164434
  16. Ràfols, C.; Bosch, E.; Ruiz, R.; Box, K.J.; Reis, M.; Ventura, C.; Santos, S.; Araújo, M.E.; Martins, F.. "Acidity and hydrophobicity of several new potential antitubercular drugs: Isoniazid and benzimidazole derivatives". Journal of Chemical and Engineering Data 57 2 (2012): 330-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856909572&partnerID=MN8TOARS.
    10.1021/je200827u
  17. Proença, C.; Serralheiro, M.L.; Araújo, M.E.; Pamplona, T.; Santos, S.; Santos, M.S.; Frazão, F.. "Novel sulfenamides as promising acetylcholinesterase inhibitors". Journal of Heterocyclic Chemistry 48 6 (2011): 1287-1294. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855197050&partnerID=MN8TOARS.
    10.1002/jhet.752
  18. Silva, D.; Norberto, F.; Santos, S.; Iley, J.. "Basic hydrolysis of quinolinyl N,N-dimethylcarbamates: A two-step mechanism". Journal of Physical Organic Chemistry 24 11 (2011): 1081-1087. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055009950&partnerID=MN8TOARS.
    10.1002/poc.1835
  19. Silva, D.; Norberto, F.; Santos, S.; Herves, P.. "Chemistry of aryl n -(2-pyridyi) thionocarbamates in basic media". Journal of Physical Organic Chemistry 22 3 (2009): 221-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-62649112914&partnerID=MN8TOARS.
    10.1002/poc.1458
  20. Gaspar, H.; Santos, S.; Carbone, M.; Rodrigues, A.S.; Rodrigues, A.I.; Uriz, M.J.; Feio, S.M.S.; et al. "Isomeric furanosesquiterpenes from the Portuguese marine sponge Fasciospongia sp.". Journal of Natural Products 71 12 (2008): 2049-2052. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149164897&partnerID=MN8TOARS.
    10.1021/np800346c
  21. Norberto, F.P.; Santos, S.P.; Iley, J.; Silvaa, D.B.; Corte Real, M.. "Kinetics and mechanism of hydrolysis of benzimidazolylcarbamates". Journal of the Brazilian Chemical Society 18 1 (2007): 171-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947235736&partnerID=MN8TOARS.
  22. Norberto, F.; Santos, S.; Silva, D.; Hervés, P.; Miguel, A.S.; Vilela, F.. "Reactivity of N-pyridylcarbamates in basic media". Journal of the Chemical Society. Perkin Transactions 2 6 (2002): 1162-1165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036623325&partnerID=MN8TOARS.
  23. Araujo, M.E.; Iley, J.; Norberto, F.P.; Santos, S.P.. "Synthesis of new N-benzoyl dithio- and trithio-allophanates by reaction of amides with cloroformates | Sintesis de nuevos N-benzoil ditio y tritiolafonatos por reaccion de amidas con cloroformatos". Informacion Tecnologica 12 5 (2001): 45-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035152193&partnerID=MN8TOARS.
  24. Norberto, F.; Santos, S.; Rodrigues, A.L.; Pazos, J.; Herves, P.. "Synthesis and reactivity of phenyl-N-methyl-N-thiobenzoylcarbamate in basic media". Journal of Chemical Research - Part S 8 (2000): 400-401. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033771471&partnerID=MN8TOARS.
  25. Santos, Susana. "Isonothoapiol: A New Phenylpropenoid from Ammi huntii". Natural Product Letters (1997):
    10.1080/10575639708043761
  26. Antunes, A.M.; Brito Palma, F.M.S.; Santos, S.M.B.P.. "Isomyristicin: 1H- and 13C-NMR assignments". Fitoterapia 66 6 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029556956&partnerID=MN8TOARS.
  27. Santos, S.M.B.P.; Brito Palma, F.M.S.; Grande, M.. "Constituents of Centaurea rothmalerana". Fitoterapia 66 3 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029041338&partnerID=MN8TOARS.
  28. Santos, S.M.B.P.; Brito Palma, F.M.S.; Urones, J.G.; Grande, M.. "Sesquiterpene lactones from Leuzea longifolia". Phytochemistry 27 11 (1988): 3672-3673. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356341&partnerID=MN8TOARS.
Magazine article
  1. Santos, Susana. "Chemical composition of Lactarius controversus, a Basidiomycetes fungus", 1997