Curriculum Vitae
Carolin Hoffmann
Identification
Personal identification
- Full name
- Carolin Hoffmann
Citation names
- Hoffmann, Carolin
Author identifiers
- Ciência ID
- 211F-792C-1B73
- ORCID iD
- 0000-0002-2528-7541
Knowledge fields
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Medical and Health Sciences - Basic Medicine - Immunology
- Engineering and Technology - Medical Engineering - Medical Laboratory Technology
Languages
| Language | Speaking | Reading | Writing | Listening | Peer-review |
|---|---|---|---|---|---|
| German (Mother tongue) | |||||
| English | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) |
| Dutch | Proficiency (C2) | Proficiency (C2) | Advanced (C1) | Proficiency (C2) | Advanced (C1) |
| Portuguese | Advanced (C1) | Advanced (C1) | Upper intermediate (B2) | Advanced (C1) | Advanced (C1) |
| French | Upper intermediate (B2) | Upper intermediate (B2) | Upper intermediate (B2) | Upper intermediate (B2) | Upper intermediate (B2) |
Education
| Degree | Classification | |
|---|---|---|
|
2013/08/01 - 2017/10/31
Concluded
|
School for Mental Health and Neurosciences (Doctor of Philosophy)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
"The brain under attack: Autoantibodies in psychotic disorders" (THESIS/DISSERTATION)
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|
|
2011/08/01 - 2013/05/03
Concluded
|
Medical Sciences (Master)
Major in Biomedicine
Karolinska Institutet, Sweden
"Optimizing protein expression and disulfide bond formation in E.Coli" (THESIS/DISSERTATION)
|
|
|
2008/08/01 - 2011/07/01
Concluded
|
Biomedical Sciences (Bachelor)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
"Detection of autoantibodies in Schizophrenia" (THESIS/DISSERTATION)
|
Affiliation
Science
| Category Host institution |
Employer | |
|---|---|---|
| 2020/09/01 - Current | Researcher (Research) | Universidade do Algarve, Portugal |
| Universidade do Algarve Centro de Investigação em Biomedicina, Portugal | ||
| 2017/11/01 - 2020/04/01 | Postdoc (Research) | Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands |
| 2018/11/01 - 2019/03/01 | Postdoc (Research) | Biodonostia Instituto de Investigación Sanitaria, Spain |
Projects
Grant
| Designation | Funders | |
|---|---|---|
| 2022/08/01 - 2024/12/31 | Epigenetic Signatures of Schizophrenia in an iPSC derived model during neuronal differentiation
ABC-RI 2022
Principal investigator
Universidade do Algarve Algarve Biomedical Center, Portugal
|
Universidade do Algarve Algarve Biomedical Center
Ongoing
|
| 2016/05/01 - 2016/07/31 | Isolation of human autoantibodies against ion channels and associated proteins
245-2016
PhD Student Fellow
Scripps Research Institute, United States
|
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH
Concluded
|
Contract
| Designation | Funders | |
|---|---|---|
| 2020/09/01 - Current | Deciphering the role of the complement system in schizophrenia
CEECIND/02649/2018
Scientific Initiation Fellow
Universidade do Algarve - Campus de Gambelas, Portugal
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal |
Associação para a Inovação e Desenvolvimento da FCT |
| 2018/03/01 - 2020/04/01 | Immune mechanisms of psychotic disorders
Kootstra_2018
Post-doc Fellow
|
|
| 2018/11/01 - 2019/04/01 | Interplay of mitochondrial and immune function in neurodegenerative conditions
Post-doc
|
|
| 2015/08/01 - 2018/10/30 | Autoantibodies in psychotic disorders
022005019
PhD Student Fellow
Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Netherlands
|
Concluded
|
| 2013/08/01 - 2014/08/01 | Establishing antibody detection methods
Kootstra_2014
PhD Student Fellow
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
|
Concluded
|
Outputs
Publications
| Journal article |
|
| Thesis / Dissertation |
|
Activities
Oral presentation
| Presentation title | Event name Host (Event location) |
|
|---|---|---|
| 2022/11/15 | Epigenetic regulation of the complement genes in Schizophrenia: In-Situ analysis and ideas for the future. | Seminar at the School of Mental Health and Neuroscience (MHeNs) at Maastricht University
School of Mental Health and Neuroscience (Maastricht, Netherlands)
|
| 2018/08/31 | Prevalence of neuronal and systemic autoantibodies in sera of patients with psychotic disorders and mental disorders without psychosis | 14th International congress on Neuroimmunology
International Society of Neuroimmunology (Brisbane, Australia)
|
Supervision
| Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
|---|---|---|
| 2023/09/11 - 2024/08/01 | Methylation signatures of interferon gamma signaling in human iPSC-derived neurons
Supervisor
|
Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
|
| 2024/03/11 - 2024/04/30 | Effect of IFN-gamma on neurodevelopment in an iPSC-derived model
Supervisor
|
Medicine (Master)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
|
| 2023/04/17 - 2023/06/30 | Testing the effect of VitaminK on complement system in cell culture systems
Supervisor
|
Ciências Biomédicas
Universidade do Algarve, Portugal
|
| 2022/04 - 2023/06 | Methylation Changes of Complement Genes during Neuronal Differentiation – a Data Mining Approach
Supervisor
|
Ciências Biomédicas
Universidade do Algarve, Portugal
|
| 2017/02/01 - 2017/09/15 | Cloning and analyzing IgG antibodies from NMDAR encephalitis and MuSk-Myasthenia Gravis patients | Biomedicine (Master)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
|
| 2016/02/01 - 2016/07/31 | Detection of Pathogenic Autoantibodies in Schizophrenia
Co-supervisor
|
Biomedicine (Master)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
|
| 2015/02/01 - 2015/07/31 | The role of the a-7 nicotinic acetylcholine receptor as a target of autoantibodies in schizophrenia
Co-supervisor
|
Biomedicine (Master)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
|
| 2015/02/01 - 2015/07/31 | Development of a cell-based assay to detect autoantibodies against the alpha-7 subunit of the nicotinic acetylcholine receptor
in schizophrenia
Co-supervisor
|
Biomedicine (Master)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
|
| 2014/12/01 - 2015/07/31 | Identification and cloning of autoantibodies in schizophrenia and encephalitis
Co-supervisor
|
Biologie en Medisch Laboratoriumonderzoek Research (Other)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
|
| 2014/02/01 - 2014/07/20 | Autoantibodies against the N-methyl-D-aspartate receptor in schizophrenia
Co-supervisor
|
Biomedical sciences (Master) |
Event organisation
| Event name Type of event (Role) |
Institution / Organization | |
|---|---|---|
| 2023/09 - Current | "Algarve Biomedical Center Research Institute - Tours" or "ABC-RI Tours"
These are bi-weekly (or on request) visits to the research labs. It show-cases the ongoing research, some of our latest findings
and gives the opportunity to meet scientists at work. We also tour the UAlgTec Health Simulation Centre with its simulators
for a wide range of health cases and scenarios. (2023/09)
Other (Co-organisor)
|
Algarve Biomedical Center Research Institute, Portugal |
| 2018/05/01 - 2018/11/28 | Member of the organization-committee of the Annual Research Day 2018 of the department of psychiatry and Neuropsychology with
the title "Career perspectives in and outside academia" (2018/11/28 - 2018/11/28)
Symposium (Member of the Organising Committee)
|
Universiteit Maastricht, Netherlands |
| 2017/03/01 - 2017/07/31 | MHeNs Translational Neuroscience Masterclass “Autoantibodies in neuropsychiatric disorders” organized June 2017 for the PhD
students of the school for Mental Health and Neuroscience (Maastricht University) as well as scientists from the Netherlands
and surrounding areas.
Role: Co-organization, oral presentation, discussion leader and moderator: guide a group discussion on different research
questions
(2017/07/14 - 2017/07/14)
Symposium (Co-organisor)
|
Universiteit Maastricht, Netherlands |
| 2017/02/01 - 2017/06/16 | Organization of parallel session: Immunity in Psychiatric syndromes during the Dutch Neuroscience Meeting, June 15th, 2017,
Lunteren (Netherlands)
Role: Co-organization, Discussion Chair, and speaker
(2017/07/15 - 2017/07/15)
Conference (Co-organisor)
|
|
| 2015/01/01 - 2015/04/18 | 9th MHeNs Translational Neuroscience Workshop “When the brain is under attack: Auto-antibodies and neurotransmitters as key
player in neurological and psychiatric diseases” was organized April 2015 for the PhD students of MHeNs at Maastricht University
Role: Co-organization, discussion leader and moderator: guide a group discussion on different research questions
(2015/04/15 - 2015/04/15)
Workshop (Co-organisor)
|
Universiteit Maastricht, Netherlands |
Event participation
| Activity description Type of event |
Event name Institution / Organization |
|
|---|---|---|
| 2023/02/24 - Current | Trainee event organized by the PsychoNeuroImmunology Research Society.
Oral presentation:” Complement genes are differentially methylated in the prefrontal cortex of individuals with schizophrenia:
a meta-analysis”.
Meeting
|
PNIRS trainee event |
| 2023/05/03 - 2023/05/05 | At Regional FENS, SPN aims to boost the development of neuroscience at national and regional levels by organising a meeting
with an outstanding scientific programme reflecting the latest breakthroughs in neuroscience, as well as its diversity.
Conference
|
Regional FENS
Algarve Biomedical Center Research Institute, Portugal
|
| 2022/12/06 - 2022/12/07 | Poster presentation: In-Situ methylation analysis of complement genes in the frontal cortex of individuals with Schizophrenia
Conference
|
Aging without borders |
| 2022/10/16 - 2022/10/17 | I represented the ABC-RI to give the general public and especially the younger generation an insight into what happens at
our research institute. We playfully explained the differentiation of different neuronal cells with a dice game where student
and their families could walk the path of differentiation/self-renewal/apoptosis. These games were a good starting point for
conversations with the participants to trigger their curiosity for the topic.
Festival
|
FICA – “Festival Internacional de Ciência 2022” in Oeiras |
| 2018/11/15 - 2018/11/17 | The Lancet Summit: Inflammation and Immunity in Disorders of the Brain and Mind, Barcelona Spain
Poster: C. Hoffmann, J. Stevens, S. Zong,et al. Alpha7 acetylcholine receptor autoantibodies detected with a new radioimmunoassay
are rare in sera of patients diagnosed with schizophrenia or bipolar disorder.
Poster:C. Hoffmann, S. Zong, M. Mané Damas, et.al. Prevalence of neuronal and systemic autoantibodies in sera of patients
with psychotic disorders and mental disorders without psychosis.
Conference
|
The Lancet Summit: Inflammation and Immunity in Disorders of the Brain and Mind |
| 2016/04/06 - 2016/04/10 | 10th international congress on autoimmunity, Leibzig (Germany)
Poster with pitch presentation: Hoffmann, C., Stevens, J., Damas, M., et al. Analysis of auto-antibodies in psychotic disorder
Chair of poster presentation session
Congress
|
10th international congress on autoimmunity |
| 2015/03/26 - 2015/03/27 | The Lancet Neurology Autoimmune Disorders Conference, Barcelona (Spain)
Poster: Hoffmann, C., Kishore Malyavantham, K., Lindemann, M.J., et al. Analysis of auto-antibodies in psychotic disorder
Conference
|
The Lancet Neurology Autoimmune Disorders Conference |
| 2015/03/13 - 2015/03/13 | Symposium "The immune-brain axis: from molecules to behavior", Hasselt (Belgium)
Oral presentation: Hoffmann , C., Kishore Malyavantham, K., Lindemann, M.J., et al. Analysis of auto-antibodies in psychotic
disorder
Symposium
|
Symposium "The immune-brain axis: from molecules to behavior" |
| 2014/11/09 - 2014/11/13 | 12th International Congress of Neuroimmunology (ICNI), Mainz (Germany)
Poster: Hoffmann, C., Lindemann, M.J., Ramsperger, V.C., et al. Analysis of autoantibodies in Schizophrenia Poster: Hoffmann,
C., Nogales-Gadea, G., Stevens et al. Analysis of pathogenic autoantibodies against the N-methyl-D-aspartate glutamate receptor
in schizophrenia
*received travel grant to attend the conference from the German Multiple Sclerosis Society (DMSG)
Conference
|
12th International Congress of Neuroimmunology |
| 2014/05/23 - 2014/05/24 | 12th Endo-Neuro-Psycho meeting, Lunteren (Netherlands)
Oral presentation: Hoffmann, C., Nogales-Gadea, G., Stevens, et al. Analysis of pathogenic autoantibodies against the N-methyl-D-aspartate
glutamate receptor in schizophrenia
Conference
|
12th Endo-Neuro-Psycho meeting |
| 2014/03/28 - 2014/03/30 | 9th international congress on autoimmunity in Nice, France
Oral presentation: Hoffmann, C., Nogales-Gadea, G., Stevens, J. et al. Analysis of pathogenic autoantibodies against the N-methyl-D-aspartate
glutamate receptor in schizophrenia
Poster: Hoffmann, C., Lindemann, M.J., Ramsperger, V.C., et al. Analysis of autoantibodies in Schizophrenia
Conference
|
9th international congress on autoimmunity |
Committee member
| Activity description Role |
Institution / Organization | |
|---|---|---|
| 2023/08 - Current | As memebr of the organizing committe of the ABC-RI days, I am organizing, divulgating and executing bi-monthyl guided tours
through our research institute.
Member
|
Algarve Biomedical Center Research Institute, Portugal |
Course / Discipline taught
| Academic session | Degree Subject (Type) | Institution / Organization | |
|---|---|---|---|
| 2023/11/06 - Current | lecture on cell culture and applications for biomedical research | Biomedical Sciences (Master) | Maastricht Universitair Medisch Centrum+, Netherlands |
| 2023/01 - Current | Lecture in the 2nd year medical course at Maastricht University as part of “Expert lectures” on the topic of “Autoantibodies in the brain”. | International Bachelor (BA) of Medicine (Bachelor) | Maastricht Universitair Medisch Centrum+, Netherlands |
| 2022/11/07 - 2022/11/23 | Practical classes within the course of "Gene and Cell Therapy" with the topic "Testing molecular activation of autophagy as therapeutic strategy in a cell model of Huntington´s disease. | Biomedical Sciences (Licenciatura) | Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal |
| 2015/09/05 - 2018/11/30 | 2015, 2016, 2017, and 2018 Lecture topics incl. neuroimmunology, immune system of the central nervous system, autoimmunity in psychotic disorders Tutorials and journal Clubs: fundamental of Neurosciences, Neuroimmunology, research methods Practical laboratory classes: Human anatomy, Sheep brain dissection practical, Cell based ELISA,Cell culture, Immunohistochemistry on rat brain, ELISA, and Dot-Blot, | fundamental Neuroscience (master),Biomedicine(Bachelor and Master),health sciences(Bachelor and Master), and Medicine (Master) (Master) | Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands |
Distinctions
Award
| 2013 | Award for the 3rd best Poster on the EURON days
European Graduate School of Neuroscience, Netherlands
|
Other distinction
| 2020 | Scientific Employment stimulus - Individual fellowship
Fundação para a Ciência e a Tecnologia, Portugal
|
| 2018 | Kootstra PostDoc Talent Fellowship
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
|
| 2018 | Travel grant
The International Society of Neuroimmunology, Italy
|
| 2016 | EMBO travel grant
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
|
| 2016 | Short Term Travel grant Boehringer Ingelheim Fonds
Boehringer Ingelheim International GmbH, Germany
|
| 2014 | Graduate School of Translational Neuroscience PhD fellowship
Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Netherlands
|
| 2013 | Koostra Student Talent Fellowship
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
|