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Currently I am working at CNC_UC-BIOTECH Animal House as responsible veterinarian and project design and execution of procedures in laboratory animal experimentation for CNC and UC researchers and external enterprises. Currently I have been working in the establishment of animal models of cancer, autoimmune diseases and drug discovery. I had been working as a post-doc associate researcher at the Laboratory for Experimental Brain Research, Lund, Sweden. I participated in the projects design, execution, data analysis, writing manuscripts, as well writing projects for financing. High experience (>10 years) in handling and maintenance of laboratory animals and the design and execution of scientific projects. Skilled in biological samples collection, treatment administration (oral gavage, subcutaneous, intravenous, intraperitoneal, intramuscular, and stereotaxic) and behavior analysis. Skilled to perform in vitro cell cultures. Dominance of several laboratory techniques that include the most commonly used techniques (western-blot, immunohistochemistry, PCR). Medical veterinarian responsible for animal welfare and member of “Organismo Responsável pelo Bem-estar dos Animais (ORBEA)” do CNC-FMUC since 2022 and FCS da Universidade da Beira Interior since 2018.
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Identification

Personal identification

Full name
Daniela de Fátima Rua Matos Talhada

Citation names

  • Talhada, Daniela

Author identifiers

Ciência ID
1D17-E1B2-A506
ORCID iD
0000-0002-5424-1438

Email addresses

  • dtalhada@cnc.uc.pt (Professional)

Addresses

  • Biocant Park Parque Tecnológico de Cantanhede, 3060-197, Cantanhede, Cantanhede, Portugal (Professional)

Websites

Knowledge fields

  • Agrarian Sciences - Veterinary Sciences
  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
Education
Degree Classification
2015/04/01 - 2020/02/24
Concluded
 Biomedicina (Doutoramento)
Major in Ciências em animais de laboratório; Acidente vascular cerebral
Universidade da Beira Interior, Portugal
"The role of transthyretin and thyroid hormones on functional recovery after experimental stroke" (THESIS/DISSERTATION)
 19
2012
Concluded
 Mestrado integrado em medicina veterinária (Mestrado)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Contribution to the study of feline pemphigus foliaceus" (THESIS/DISSERTATION)
 16 (dezasseis) valores
Affiliation

Science

Category
Host institution 		Employer
2025/10/23 - Current Invited Auxiliary Researcher (Research) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2021/07/01 - 2022/04/14 Auxiliary Researcher (Research) Lunds universitet Biomedicinskt centrum, Sweden
Lunds universitet Biomedicinskt centrum, Sweden
2019/04/01 - 2021/06/30 Postdoc (Research) Lunds universitet Biomedicinskt centrum, Sweden
Lunds universitet Biomedicinskt centrum, Sweden

Other Careers

Category
Host institution 		Employer
2022/04/15 - 2025/10/22 Técnico Superior (Técnico Superior) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2015/04/01 - 2019/03/31 PhD Student Universidade da Beira Interior, Portugal
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2015/04/01 - 2019/03/31 The role of transthyretin and thyroid hormones on functional recovery after experimental stroke
SFRH/BD/104679/2014
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021 - 2022 Actions of dopaminergic signalling on inhibitory neurotransmission after stroke
314344:146918
Post-doc
Lunds universitet Biomedicinskt centrum, Sweden
 Kungliga Fysiografiska Sällskapet I Lund
Concluded
2021 - 2022 Plasticity enhancing actions of dopamine signalling after stroke
none
Post-doc
Lunds universitet Biomedicinskt centrum, Sweden
 Thorsten Och Elsa Segerfalks Stiftelse
Concluded
2019/01/01 - 2019/12/31 Centro de Investigação em Ciências da Saúde
UID/Multi/00709/2019
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Hakon J; Quattromani MJ; Sjölund C; Talhada D; Byungchan Kim; Moyanova S; Mastroiacovo F; et al. "Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity.". Brain : a journal of neurology (2024): https://europepmc.org/articles/PMC10766240.
    10.1093/brain/awad293
  2. Talhada D; Ruscher K. "Performing Enriched Environment Studies to Improve Functional Recovery.". Methods in molecular biology (Clifton, N.J.) (2023): https://doi.org/10.1007/978-1-0716-2926-0_24.
    10.1007/978-1-0716-2926-0_24
  3. Ana González-Manteiga; M Carmen Navarro; Sebestyén VE; Saborit-Torres JM; Talhada D; Vayá MI; Karsten Ruscher; Pietro Fazzari. "A Novel In Vivo Model for Multiplexed Analysis of Callosal Connections upon Cortical Damage.". International journal of molecular sciences (2022): https://europepmc.org/articles/PMC9368090.
    10.3390/ijms23158224
  4. Talhada D; Niklas Marklund; Wieloch T; Kuric E; Ruscher K. "Plasticity-Enhancing Effects of Levodopa Treatment after Stroke.". International journal of molecular sciences (2021): https://europepmc.org/articles/PMC8508853.
    10.3390/ijms221910226
  5. Georgios Michalettos; Walter HL; Antunes ARP; Wieloch T; Talhada D; Karsten Ruscher. "Effect of Anti-inflammatory Treatment with AMD3100 and CX3CR1 Deficiency on GABAA Receptor Subunit and Expression of Glutamate Decarboxylase Isoforms After Stroke.". Molecular neurobiology (2021): https://europepmc.org/articles/PMC8599239.
    10.1007/s12035-021-02510-x
  6. Cruz, Carla; Pedro, Augusto Q.; Carvalho, Josué; Santos, Tiago; Talhada, Daniela; Paiva, Artur; Queiroz, João A.; et al. "Nucleolin as a potential biomarker for canine malignant neoplasia". Research in Veterinary Science (2020): http://dx.doi.org/10.1016/j.rvsc.2020.10.004.
    10.1016/j.rvsc.2020.10.004
  7. Duarte, Ana C.; Furtado, André; Hrynchak, Mariya V.; Costa, Ana R.; Talhada, Daniela; Gonçalves, Isabel; Lemos, Manuel C.; Quintela, Telma; Santos, Cecília R.A.. "Age, Sex Hormones, and Circadian Rhythm Regulate the Expression of Amyloid-Beta Scavengers at the Choroid Plexus". International Journal of Molecular Sciences 21 18 (2020): 6813. http://dx.doi.org/10.3390/ijms21186813.
    Published • 10.3390/ijms21186813
  8. Daniela Talhada; Ana Raquel Costa-Brito; Ana Catarina Duarte; Ana Raquel Costa; Telma Quintela; Joana Tomás; Isabel Gonçalves; Cecília Reis Alves Santos. "The choroid plexus: Simple structure, complex functions". Journal of Neuroscience Research (2020): https://doi.org/10.1002/jnr.24571.
    10.1002/jnr.24571
  9. "Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke.". Frontiers in Neurology (2019): http://europepmc.org/articles/PMC6814074.
    10.3389/fneur.2019.01103
  10. Talhada, D.; Gonçalves, I.; Santos, C.R.; Ruscher, K.. "Transthyretin expression in the postischemic brain". PLoS ONE 14 9 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071756786&partnerID=MN8TOARS.
    10.1371/journal.pone.0221555
  11. Talhada, D.; Feiteiro, J.; Costa, A.R.; Talhada, T.; Cairraõ, E.; Wieloch, T.; Englund, E.; et al. "Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional outcome after stroke". Acta Neuropathologica Communications 7 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077089425&partnerID=MN8TOARS.
    10.1186/s40478-019-0866-4
  12. Saraiva, C.; Talhada, D.; Rai, A.; Ferreira, R.; Ferreira, L.; Bernardino, L.; Ruscher, K.. "MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo". PLoS ONE 13 3 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042940584&partnerID=MN8TOARS.
    10.1371/journal.pone.0193609
  13. Quintela, T.; Gonçalves, I.; Silva, M.; Duarte, A.C.; Guedes, P.; Andrade, K.; Freitas, F.; et al. "Choroid plexus is an additional source of melatonin in the brain". Journal of Pineal Research 65 4 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055159557&partnerID=MN8TOARS.
    10.1111/jpi.12528
  14. Talhada, D.; Rabenstein, M.; Ruscher, K.. "The role of dopaminergic immune cell signalling in poststroke inflammation". Therapeutic Advances in Neurological Disorders 11 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85054850501&partnerID=MN8TOARS.
    10.1177/1756286418774225
  15. Quintela, T.; Albuquerque, T.; Lundkvist, G.; Carmine Belin, A.; Talhada, D.; Gonçalves, I.; Carro, E.; Santos, C.R.A.. "The choroid plexus harbors a circadian oscillator modulated by estrogens". Chronobiology International 35 2 (2018): 270-279. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035097479&partnerID=MN8TOARS.
    10.1080/07420528.2017.1400978
  16. Faustino-Rocha, A.I.; Rodrigues, D.; Gil da Costa, R.M.; Diniz, C.; Aragão, S.; Talhada, D.; Botelho, M.; et al. "Trihalomethanes in liver pathology: Mitochondrial dysfunction and oxidative stress in the mouse". Environmental Toxicology 31 8 (2016): 1009-1016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84977556089&partnerID=MN8TOARS.
    10.1002/tox.22110
  17. Teixeira-Guedes CI; Faustino-Rocha AI; Talhada D; Duarte JA; Ferreira R; Seixas F; Oliveira PA. "A liver schwannoma observed in a female Sprague-Dawley rat treated with MNU.". (2014): http://europepmc.org/abstract/med/24315155.
    10.1016/j.etp.2013.11.003
  18. Henriques A; Arantes-Rodrigues R; I Faustino-Rocha A; I Teixeira-Guedes C; Pinho-Oliveira J; Talhada D; H Teixeira J; et al. "The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis.". Iranian journal of basic medical sciences (2014): http://europepmc.org/abstract/med/24711900.
  19. C.I. Teixeira-Guedes; A. Andrade; D. Talhada; A.I. Faustino-Rocha; R.M. Gil da Costa; M.J. Pires; A. Gama; et al. "Effects of Moderate Exercise in an Animal Model of Chemically-induced Mammary Tumours". Journal of Comparative Pathology 150 1 (2014): 109-109. http://dx.doi.org/10.1016/j.jcpa.2013.11.138.
    10.1016/j.jcpa.2013.11.138
  20. "Recommendations for Urine and Urinary Bladder Collection in Rodents’ Chemical Carcinogenesis Assays". Scandinavian Journal of Laboratory Animal Science (2014):
  21. Henriques, A.; Arantes-Rodrigues, R.; Faustino-Rocha, A.I.; Teixeira-Guedes, C.I.; Pinho-Oliveira, J.; Talhada, D.; Teixeira, J.H.; et al. "The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis". Iranian Journal of Basic Medical Sciences 17 2 (2014): 145-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894273974&partnerID=MN8TOARS.
  22. Soares-Maia R; Faustino-Rocha A; Teixeira-Guedes C; Pinho-Oliveira J; Talhada D; Rema A; Faria F; et al. "MNU-induced rat mammary carcinomas: immunohistology and estrogen receptor expression.". (2013): http://europepmc.org/abstract/med/24099429.
    10.1615/JEnvironPatholToxicolOncol.2013007541
  23. Ferreiro, L.; Machado, J.; Faustino-Rocha, A.I.; Talhada, D.; Pires, M.J.; Colaço, B.; Ginja, M.; Sargo, T.; Oliveira, P.A.. "Hyperadrenocorticism in dogs with clinical manifestations". Veterinary Practitioner 14 2 (2013): 413-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051849964&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Talhada, Daniela de Fátima Rua Matos. "Contribution to the study of feline pemphigus foliaceus". Master, 2014. http://hdl.handle.net/10348/3102.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/04/29 Dopamine signaling modulation after stroke XIV Ciclo de Seminários
CICS-UBI (Covilhã, Portugal)
2019 Impact of triiodothyronine in recovery mechanisms after stroke. III International Congress in Health Sciences Research – Trends in Aging and Cancer III International Congress in Health Sciences Research – Trends in Aging and Cancer
CICS-UBI (Covilhã, Portugal)
2017 Transthyretin expression in the postischemic brain. XII Annual Symposium CICS-UBI
CICS-UBI (Covilhã, Portugal)
2016 Effects of thyroid hormone treatment on functional recovery after experimental stroke. XI Annual Symposium CICS-UBI
CICS-UBI (Covilhã, Portugal)
2015 Effects of thyroid hormone treatment on functional recovery after experimental stroke. I International Congress in Health Sciences Research – Trends in Endocrinology and Neurosciences
CICS-UBI (Covilhã, Portugal)
2013 Caraterização das lesões cutâneas num modelo de cancro da pele de dois estadios em murganhos ICR. Comunicação livre nas III Jornadas de Saúde Pública.
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017 - 2017 Member of the organizational committee “II International Congress in Health Sciences Research – Trends in Biotechnology for Biomedical Applicants” (2017 - 2017)
Congress (Member of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Distinctions

Award

2019 Winner of the juror´s choice and people´s choice awards in the June NeuroArt Image Contest
MBF Bioscience, United States
2011 Inácio Ribeiro; Nunes Petisca; Ildefonso Borges; Ferreira Lapa; Bernardo Lima
Sociedade Portuguesa de Ciências Veterinárias, Portugal