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Inês G. Mollet is a researcher in molecular mechanisms of metabolic and cardiovascular disease, with a degree in Biological Engineering (Université Libre de Bruxelles and Instituto Superior Técnico, Lisbon) and a PhD in Biomedical Sciences from Instituto de Medicina Molecular with Prof. Carmo-Fonseca (Faculdade de Medicina da Universidade de Lisboa, IMM/FMUL) funded by Muscular Dystrophy Association "Profiling alternative splicing in muscular dystrophies" - MDA3662 (2005-2007) and European Alternative Splicing Network of Excellence (2007-2009 EURASNET). Developed during PhD one of the first alternative splicing databases ExonMine to investigate mechanisms of alternative splicing in disease context and published 3 articles. After PhD, worked at Imperial College London (National Heart & Lung Institute, UK) as Research Associate with Dr. Shovlin, maintaining collaborations on gene loci associated with hereditary haemorrhagic telangiectasia using high throughput sequencing publishing 3 articles. During 2010-2016 worked at Lund University Diabetes Centre (Sweden) as Postdoctoral Fellow and Assistant Researcher with Prof. Lena Eliasson (Islet Cell Exocytosis Unit) and Prof. Marju Orho-Melander (Diabetes and Cardiovascular Disease - Genetic Epidemiology Unit), deciphering islet pathophysiology in both rodent models of diabetes and human islets of Langerhans with bioinformatic, wet lab and microscopy involving 17 publications. Collaborated with Dr. Isabel Gonçalves on omics data analysis of human carotid plaques linked to cerebrovascular events that identified tissue and metabolic biomarkers of atherosclerotic plaque vulnerability (5 publications). In 2017 joined NOVA Medical School Research (Lisbon, Portugal) working with Prof. Paula Macedo on effects of plasma exosome derived microRNAs in Metabolic dysfunction-associated fatty liver disease (MAFLD) (1 publication 2021), and with Prof. Helena Vieira on remote ischemic conditioning and plasma proteomics of stroke patients (4 publications). Began independent research in 2017: presented preliminary in-silico analyses, that supported neural involvement in early diabetes aetiology, at the British Society for Neuroendocrinology Gut-brain axis Symposium in Sep 2017 (UK) and was awarded seed funding Project Support Grant (BSN-PSG-2017) to study "Nervous system signalling in the diabetic gut - Links between disrupted nutrient sensing and GABAergic signals". In 2019 set up a Clinical Observational Study (REMIDIA) as principal investigator with surgical team at Digestive Pathology Clinic of Instituto Português de Oncologia FG (IPO-Porto) and NOVA Medical School to investigate novel diabetic targets in human gut biopsies. Since 2021, coordinates proteomics analysis of gut biopsies from bariatric surgery patients in the RESTART Clinical Study coordinated by Prof. Cláudia Marques (FCM|NMS/CINTESIS). In 2021 joined Disease Pathways and Biomarkers research at UCIBIO Applied Molecular Bioscience Unit at FCT-NOVA (Caparica, Portugal) as Senior Researcher. Was awarded funding from Fundação para a Ciência e Tecnologia (DUOBETES - EXPL/MED-PAT/0852/2021) to screen for new high potential therapeutic targets in duodenum against type 2 diabetes". Has supervised 2 Master Theses and taught in curricular units of Masters in Biomedicine (Lund Univ.), PhD Program (NOVA Medical School, Lisbon) and Masters in Biochemistry (FCT-NOVA, Lisbon). In 2023 was awarded six-year individual position funding from Fundação para a Ciência e Tecnologia (2022.03258.CEECIND). Currently researches aetiology of diabetes by investigating early changes in transcriptional and proteomic profiles in the gut of diabetic patients experiencing diabetes remission after metabolic surgery as well as dietary bioactive compounds with therapeutic potential.
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Identification

Personal identification

Full name
Inês Maria de Stoop Camões Teixeira Guerra Mollet

Citation names

  • Mollet, Inês G.

Author identifiers

Ciência ID
1917-E031-10E3
ORCID iD
0000-0002-1422-1336

Email addresses

  • i.mollet@fct.unl.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English (Mother tongue)
Portuguese (Mother tongue)
French (Mother tongue)
Education
Degree Classification
2020/12/09
Concluded
 Carrying out procedures on animals and designing procedures and projects (Pós-doutoramento)
Direcção-Geral de Alimentação e Veterinária, Portugal
2018/03/21
Attended
 Intelectual Property in the Academic Context (Outros)
Universidade Nova de Lisboa, Portugal
2013/09/07
Concluded
 Laboratory Animal Science for Researchers - Rodents and Lagomorphs (Pós-doutoramento)
Karolinska Institutet, Sweden
2012/12/07 - 2012/12/17
Concluded
 Teaching Problem-Based Learning (Pós-doutoramento)
Lunds Universitet, Sweden
2012/11/05 - 2012/11/22
Concluded
 Lecturer Teaching Course - Perspectives on Learning (Lund University) (Pós-doutoramento)
Lunds Universitet, Sweden
2012/06/04
Concluded
 Course for Doctoral Supervisors (Pós-doutoramento)
Lunds Universitet, Sweden
2009/04/14
Concluded
 Biomedical Sciences - Morphological Sciences (Doutoramento)
Instituto de Medicina Molecular, Portugal
"Genome Wide Mining Of Alternative Splicing In Metazoan Model Organisms" (THESIS/DISSERTATION)
 Distinction and honors
2002/01/09
Concluded
 Engenharia Biológica (Mestrado integrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1994/07/08
Concluded
 Ingenieur Biochimiste (Licence)
Université Libre de Bruxelles, Belgium
"Culture of human and bovine endothelial cells on microspheres in a bioreactor and infection of with the bacteria Cowdria Ruminantium for vaccine production" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution		 Employer
2023/05/02 - Current Auxiliary Researcher (Research) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/10 - Current Researcher (Research) Associação para a Inovação e Desenvolvimento da FCT, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2019/08/02 - 2021/07/31 Contracted Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016/06/01 - 2019/07/31 Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2013/02/01 - 2016/04/30 Visiting Researcher (Research) Imperial College London, United Kingdom
2014/03/01 - 2016/03/01 Research Assistant (Research) Lunds Universitet, Sweden
2010/03/01 - 2014/03/01 Postdoc (Research) Lunds Universitet, Sweden
2010/01/01 - 2012/05/01 Visiting Researcher (Research) Imperial College London, United Kingdom
Projects

Grant

Designation Funders
2022/01/09 - Current Screening for new high potential therapeutic targets in duodenum against type 2 diabetes
EXPL/MED-PAT/0852/2021
UID/04378/2025
UID/PRR/04378/2025
LA/P/0140/2020
NOVA.id.FCT - Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associate Laboratory Institute for Health and Bioeconomy, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/01/01 - Current Nervous system signalling in the diabetic gut - Links between disrupted nutrient sensing and GABAergic signals
93112017 - BSN-PSG-2017
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 British Society for Neuroendocrinology
Ongoing
2025/09/29 - 2029/09/28 CA24166 - Pan-European Network for Inflammaging: A Multi-omics Integration Approach (INFLAMomx)
CA24166
Secondary Proponent
Sveleucilište u Splitu, Croatia
 European Cooperation in Science and Technology
Ongoing
2018/10/01 - 2021/09/30 Metabolic chronic diseases stratification: a case for gut-liver axis derived exosomes
PTDC/MEC-MET/29314/2017
Post-doc
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/08/02 - 2021/08/01 Remote ischemic post-conditioning in acute phase of ischemic stroke – disclosing novel circulating biomarkers and clinical trial for improving outcome
C493995942-00091545
Research Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/02/01 - 2019/06/30 Hepatic inflammation, insulin clearance and hyperinsulinemia: a triad at the basis of prediabetes.
PTDC/BIM-MET/2115/2014
Post-doc Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2005 - 2007 Profiling alternative splicing in muscular dystrophies"
MDA3662 (2005-2007)

Contract

Designation Funders
2023/09/01 - Current Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
10.54499/LA/P/0087/2020
Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal

Universidade Nova de Lisboa, Portugal

GREEN-IT, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Instituto para a Saúde e a Bioeconomia
LA/P/0140/2020
10.54499/LA/P/0140/2020
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/10 - 2024/01/09 Screening for new high potential therapeutic targets in duodenum against type 2 diabetes
EXPL/MED-PAT/0852/2021
10.54499/EXPL/MED-PAT/0852/2021
Principal investigator
Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa, Portugal

iNOVA4Health, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2021/09/30 Estratificação de doenças metabólicas crónicas: exossomas derivados de eixo hepático-intestinal.
PTDC/MEC-MET/29314/2017
Universidade de Aveiro, Portugal

Universidade Nova de Lisboa, Portugal

Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2010/03/01 - 2016/02/29 EXODIAB: Excellence in Diabetes Research in Sweden
NA
Post-doc Fellow
Lunds Universitet, Sweden
 Vetenskapsradet
Ongoing
2006/01/01 - 2009/04 European alternative splicing network of excellence
518238
PhD Student Fellow
Instituto de Medicina Molecular, Portugal
 European Commission Sixth Framework Programme
Concluded

Other

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/23 - 2025/01/23 REMIDIA-1 “Alvos Intestinais Farmacológicos para Induzir Remissão da Diabetes Tipo 2”
no133/2019/CEFCM
Principal investigator
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Mollet IG. "Potencial do bio-marcador sanguíneo miRNA-193b-3p para diagnosticar alterações do metabolismo lipídico na pré-diabetes". Paper presented in 16° Congresso Português de Diabetes (Portuguese Congress on Diabetes), Albufeira, 2020.
  2. Mollet IG. Corresponding author: Mollet IG. "Nervous system signalling in the diabetic gut – Links between disrupted nutrient sensing and neurotrophic and GABAergic signalling in pre-diabetes". Paper presented in British Society for Neuroendocrinology - Annual Meeting, Nottingham, 2017.
  3. Malm HA; Esguerra JLS; Orho-Melander M; Eliasson L; Mollet IG. "Identification of novel targets of the miR-212/132 cluster involved in Wnt-signalling and regulation of insulin secretion in the pancreatic beta cell". Paper presented in European Association for the Study of Diabetes (EASD) Congress - Diabetologia, 2015.
  4. Shovlin CL; Awan I; Naziya AF; Govani FS; Mollet I; Patel D. "P69 One in twenty patients with hereditary hemorrhagic telangiectasia report iron treatments precipitate nosebleeds". Paper presented in 11th International HHT Scientific Conference - Angiogenesis, Florida, 2015.
  5. Malm HA; Berggreen C; Orho-Melander M; Eliasson L; Göransson O; Mollet IG. "Dephosphorylation and nuclear translocation of the CREB-regulated transcription co-activator 1 (CRTC1) elevates miR-212 and miR-132 expression in insulin secreting cells". Paper presented in European Association for the Study of Diabetes (EASD) Congress - Diabetologia, 2014.
  6. Malm HA; Mollet, Inês G; Esguerra JL; Orho-Melander M; Eliasson L. "cAMP mediated regulation of miR-212/132 expression in insulin secreting cells acts through CREB-regulated transcription co-activator 1 (CRTC1)". Paper presented in European Association for the Study of Diabetes (EASD) Congress 2013 - Diabetologia, Barcelona, 2013.
  7. Salunkhe VA; Andersson SA; Esguerra JLS; Mollet IG; Wendt A; Eliasson L. "Regulation of miR-335 expression contributes to orchestrate insulin secretion at the level of exocytosis in insulin secreting INS-1 832/13 cells". Paper presented in European Association for the Study of Diabetes (EASD) Congress 2013 - Diabetologia, Barcelona, 2013.
    https://doi.org/10.1007/s00125-013-3012-z
  8. Hindy G; Mollet IG; Rukh G; Ericson U; Orho-Melander M. "Several type 2 diabetes associated variants in genes involved in WNT- signalling interact with dietary fibre intake on type 2 diabetes incidence". Paper presented in European Association for the Study of Diabetes (EASD) Congress 2013, Barcelona, 2013.
  9. Sharoyko VV; Landin M; Mollet IG; Spégel P; Eliasson L; Wierup N; Mulder H. "Deficiency of TFB1M leads to beta cell dysfunction and development of diabetes". Paper presented in European Association for the Study of Diabetes (EASD) Congress 2012, Diabetologia, 2012.
    https://doi.org/10.1007/s00125-012-2688-9
Conference poster
  1. Mollet, Inês G.; Videira, José Flávio. "Proteomics of human duodenum in type 2 diabetes - insights into intestinal malfunction". Paper presented in XXII National Congress of Biochemistry - Nex-Gen Biochemical Challenges Across Borders, 2024.
  2. Mollet, Inês G.; Glória Alves, Beatriz. Corresponding author: Mollet, Inês G.. "Dietary Lignans as Potential Nutraceuticals Against Neural Damage Induced by Hight Fat Diet". Paper presented in 35th Annual Conference & Meeting, 2024.
  3. Mollet, Inês G.; Videira, José Flávio. Corresponding author: Mollet, Inês G.. "Profiling duodenal enteric nervous system typology changes in prediabetes and type 2 diabetes in human and mouse". Paper presented in British Society for Neuroendocrinology Annual Meeting - Exeter 2023, 2023.
  4. Mollet, Inês G.; Mira M. "Distinct Disruption of Enteric GABA(B) Receptor Transduction in Type 2 Diabetes and Ageing". Paper presented in Annual British Society for Neuroendoicrinology and the Société de Neuroendcrinologie joint meeting, 2021.
  5. Malm HA; Esguerra JLS; Orho-Melander M; Eliasson L. Corresponding author: Malm HA. "Neuronal Signaling in the Diabetic Gut – Evidence of Enteric Neuro-Endocrine GABAergic Regulation by Subtype-Specific KCTD Auxiliary Subunits". Paper presented in Meeting of the Portuguese Society for Neurosciences SPN2019, 2019.
  6. Mollet, Inês G.. "GABAB Receptors in Subpopulations of Enteric Neuronal and Enteroendocrine Cells in the Proximal Small Intestine are Regulated by Subtype-specific KCTD Auxiliary Subunits". Paper presented in The British Neuroscience Association BNA2019 Festival of Neuroscience, Dublin, Ireland., 2019.
  7. Mollet, Inês G.. "Blood Bio-Marker miR-193b-3p in Pre-Diabetes Regulates Metabolic Disruption through PGC1a, a Master Controler of Glucose and Fatty Acid Metabolism". Paper presented in 15° Congresso Português de Diabetes, Albufeira, Portugal, 2019.
  8. Mollet IG. "Plasma mir-193b-3p could be a biomarker for pre-diabetes progression or regression". Paper presented in 14th Portuguese Congress on Diabetes, 2018.
  9. Mollet IG. "Study of regulation of gene expression by circulating microRNAs (c-miRNAs) previously associated with diabetes and NAFLD reveals convergence of action on insulin regulatory mechanisms and its metabolism". Paper presented in 13th Portuguese Congress on Diabetes, Albufeira, Portugal, 2017.
  10. Eliasson L; Salunkhe VA; Reinbothe T; Mollet IG; Wendt A; Vikman J. "Mice on high fat diet or normal diet have different metabolic responses to rosuvastatin treatment ( Diabetologia 58:S306)". Paper presented in European Association for the Study of Diabetes (EASD) Congress, 2015.
  11. Mollet IG. "CAMTA1 - Calcium-Calmodulin Transcriptional Activator, a new player in the regulation of microRNAs and insulin secretion". Paper presented in European Association for the Study of Diabetes - Islet Study Group Meeting (ISG-EASD), Lausanne)., 2014.
  12. Christensen GL; Jacobsen MLB; Eliasson L; Frederiksen KS; Mollet IG; Friberg J; Bruun C; Billestrup N. "Bone morphogenetic protein 4 inhibits insulin secretion by regulation of Calbindin expression". Paper presented in European Association for the Study of Diabetes -.Islet Study Group Meeting (ISG-EASD), 2013.
  13. Mollet IG; Malm H; Orho-Melander M; Eliasson L. "A calmodulin-binding transcription activator modulates miR-212 and miR-132 expression and insulin secretion in INS-1 832/13 ß-cells". Paper presented in European Association for the Study of Diabetes - Islet Study Group Meeting (ISG-EASD) 2013, Barcelona., 2013.
  14. Salunkhe VA; Braun, M; Esguerra JLS; Mollet, I; Wendt, A; Stoffel, M; Rorsman, P; Eliasson, L. "Influence of miR-375 on electrophysiological properties of voltage-dependent Na+ channels in mouse beta cells". Paper presented in Beta Cell workshop - Programming Beta Cell Development, Impairment and Regeneration, 2011.
  15. Ben-Dov, C; Lozano, JJ; Sammeth, M; Mollet, I; Carmo-Fonseca, M; Valcarcel, J. "Exploring Cellular Codes of Splicing Regulation Using Splicing-Sensitive Microarrays". Paper presented in International Workshop on High Throughput Technologies for Alternative Splicing, 2009.
  16. Mollet, IG; Ben-Dov C; Felício-Silva D; Grosso, AR; Eleutério P; Silva, TS; Carmo-Fonseca, M. ""ExonMine - Unconstrained mining for exons and alternative splicing"". Paper presented in 17th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & 8th European Conference on Computational Biology (ECCB), 2009.
  17. Grosso, AR; Mollet, IG; Carmo-Fonseca, M. "Genome-wide bioinformatics search for cancer-associated splicing misregulation". Paper presented in First International EURASNET Conference on Alternative Splicing, 2009.
Journal article
  1. Alves, Beatriz D.G.; Monteiro, Paula; Martins, Pedro C.; Braga, José; Matthiesen, Rune; Videira, José Flávio G.; Mollet, Inês G.. "Proteomics of human duodenum in pre-diabetes and type 2 diabetes reveals potential novel therapeutic targets for aetiology and therapeutics". Clinical Proteomics 23 1 (2026): https://doi.org/10.1186/s12014-026-09595-3.
    10.1186/s12014-026-09595-3
  2. Inês Guerra Mollet; Ricardo Viana-Soares; Catarina Cardoso-Pires; Nuno L. Soares; João Pedro Marto; Marcelo Mendonça; Cláudia S.F. Queiroga; et al. "Identification of human circulating factors following remote ischemic conditioning (RIC)". Free Radical Biology And Medicine 224 (2024): 23-38. https://novaresearch.unl.pt/en/publications/7bb934a5-d39f-46c4-ae11-299540048947.
    10.1016/j.freeradbiomed.2024.08.017
  3. Marto, João Pedro; Carvalho, Ana Sofia; G. Mollet, Inês; Mendonça, Marcelo; Salavisa, Manuel; Meira, Bruna; Fernandes, Marco; et al. "Proteomics to Identify New Blood Biomarkers for Diagnosing Patients With Acute Stroke". Journal of the American Heart Association 12 22 (2023): http://dx.doi.org/10.1161/jaha.123.030021.
  4. Mollet, Inês Guerra; Macedo, Maria Paula. "Pre-Diabetes-Linked miRNA miR-193b-3p Targets PPARGC1A, Disrupts Metabolic Gene Expression Profile and Increases Lipid Accumulation in Hepatocytes: Relevance for MAFLD". International Journal of Molecular Sciences 24 4 (2023): 3875. http://dx.doi.org/10.3390/ijms24043875.
    10.3390/ijms24043875
  5. Marto, J.P.; Carvalho, A.S.; Mollet, I.G.; Mendonça, M.; Salavisa, M.; Meira, B.; Fernandes, M.; et al. "Proteomics to Identify New Blood Biomarkers for Diagnosing Patients With Acute Stroke". Journal of the American Heart Association 12 22 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85178437525&partnerID=MN8TOARS.
    10.1161/JAHA.123.030021
  6. Mollet, Inês; Martins, Catarina; Ângelo-Dias, Miguel; Carvalho, Ana S.; Aloria, Kerman; Matthiesen, Rune; Viana-Baptista, Miguel; Borrego, Luís Miguel; Vieira, Helena L.A.. "Pilot study in human healthy volunteers on the mechanisms underlying remote ischemic conditioning (RIC) – Targeting circulating immune cells and immune-related proteins". Journal of Neuroimmunology 367 (2022): 577847. http://dx.doi.org/10.1016/j.jneuroim.2022.577847.
    10.1016/j.jneuroim.2022.577847
  7. Mollet, Inês; Marto, João Pedro; Mendonça, Marcelo; Baptista, Miguel Viana; Vieira, Helena L. A.. "Remote but not Distant: a Review on Experimental Models and Clinical Trials in Remote Ischemic Conditioning as Potential Therapy in Ischemic Stroke". Molecular Neurobiology (2021): http://dx.doi.org/10.1007/s12035-021-02585-6.
    10.1007/s12035-021-02585-6
  8. Xiao, S; Brown, D; Mollet, IG; Govani, FS; Patel, D; Game, L; Shovlin, CL. "S95 Identifying new hereditary haemorrhagic telangiectasia genes by applying a machine learning approach to screen whole genome sequencing data". Thorax 74 (2019): A59-A60. http://dx.doi.org/10.1136/thorax-2019-BTSabstracts2019.101.
    10.1136/thorax-2019-btsabstracts2019.101
  9. Bernabeu-Herrero M; Patel D; Govan FS; Dibb NJ; Game L; Aldred M; Mollet IG; Shovlin CL. "S94 Identification of natural targets of nonsense-mediated decay relevant to pulmonary vascular diseases". Thorax 74 (2019): A95. http://dx.doi.org/10.1136/thorax-2019-BTSabstracts2019.100.
  10. A. Edlund; M. Barghouth; M. Hühn; M. Abels; J. S.E. Esguerra; Inês Guerra Mollet; E. Svedin; et al. "Defective exocytosis and processing of insulin in a cystic fibrosis mouse model". Journal of Endocrinology 241 1 (2019): 45-57. https://novaresearch.unl.pt/en/publications/78ef9c31-66ba-4976-a0a0-a5f610b78f17.
    10.1530/JOE-18-0570
  11. Tomas, Lukas; Edsfeldt, Andreas; Mollet, Inês G; Perisic Matic, Ljubica; Prehn, Cornelia; Adamski, Jerzy; Paulsson-Berne, Gabrielle; et al. "Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques". European Heart Journal 39 24 (2018): 2301-2310. http://dx.doi.org/10.1093/eurheartj/ehy124.
    10.1093/eurheartj/ehy124
  12. Henaoui IS; Jacovetti C; Guerra Mollet I; Guay C; Sobel J; Eliasson L; Regazzi R. "PIWI-interacting RNAs as novel regulators of pancreatic beta cell function.". Diabetologia (2017): http://europepmc.org/abstract/med/28711973.
    10.1007/s00125-017-4368-2
  13. Nicholas LM; Valtat B; Medina A; Andersson L; Abels M; Mollet IG; Jain D; et al. "Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic ß-cells.". Molecular metabolism (2017): http://europepmc.org/abstract/med/28702322.
    10.1016/j.molmet.2017.05.005
  14. Wendt A; Mollet IG; Knutsson A; Bolmgren VS; Hultgårdh-Nilsson A; Gomez MF; Eliasson L. "Osteopontin Affects Insulin Vesicle Localization and Ca2+ Homeostasis in Pancreatic Beta Cells from Female Mice.". PloS one (2017): http://europepmc.org/abstract/med/28107503.
    10.1371/journal.pone.0170498
  15. Ofori JK; Malm HA; Mollet IG; Eliasson L; Esguerra JLS. "Confluence does not affect the expression of miR-375 and its direct targets in rat and human insulin-secreting cell lines.". PeerJ (2017): http://europepmc.org/abstract/med/28674658.
    10.7717/peerj.3503
  16. Kjellqvist S; Klose C; Surma MA; Hindy G; Mollet IG; Johansson A; Chavaux P; et al. "Identification of Shared and Unique Serum Lipid Profiles in Diabetes Mellitus and Myocardial Infarction.". Journal of the American Heart Association (2016): http://europepmc.org/abstract/med/27899364.
    10.1161/JAHA.116.004503
  17. Mollet IG; Malm HA; Wendt A; Orho-Melander M; Eliasson L. "Integrator of Stress Responses Calmodulin Binding Transcription Activator 1 (Camta1) Regulates miR-212/miR-132 Expression and Insulin Secretion". Journal of Biological Chemistry 291 35 (2016): 18440-18452. https://doi.org/10.1074%2Fjbc.m116.716860.
    10.1074/jbc.M116.716860
  18. Salunkhe VA; Mollet IG; Ofori JK; Malm HA; Esguerra JL; Reinbothe TM; Stenkula KG; et al. "Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion.". EBioMedicine (2016): http://europepmc.org/abstract/med/27453321.
    10.1016/j.ebiom.2016.07.007
  19. Edsfeldt A; Dunér P; Ståhlman M; Mollet IG; Asciutto G; Grufman H; Nitulescu M; et al. "Sphingolipids Contribute to Human Atherosclerotic Plaque Inflammation.". (2016): http://europepmc.org/abstract/med/27055903.
    10.1161/ATVBAHA.116.305675
  20. Bennet H; Mollet IG; Balhuizen A; Medina A; Nagorny C; Bagge A; Fadista J; et al. "Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.". (2016): http://europepmc.org/abstract/med/26733006.
    10.1007/s00125-015-3847-6
  21. Malm HA; Mollet IG; Berggreen C; Orho-Melander M; Esguerra JL; Göransson O; Eliasson L. "Transcriptional regulation of the miR-212/miR-132 cluster in insulin-secreting ß-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases.". (2016): http://europepmc.org/abstract/med/26797246.
    10.1016/j.mce.2016.01.010
  22. Mollet IG; Patel D; Govani FS; Giess A; Paschalaki K; Periyasamy M; Lidington EC; et al. "Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes.". (2016): http://europepmc.org/abstract/med/26866805.
    10.1371/journal.pone.0147990
  23. Reinbothe TM; Mollet IG. "Optogenetic Control of Pancreatic Islets.". (2016): http://europepmc.org/abstract/med/26965119.
    10.1007/978-1-4939-3512-3_8
  24. Hindy G; Mollet IG; Rukh G; Ericson U; Orho-Melander M. "Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes.". Genes & nutrition (2016): http://europepmc.org/abstract/med/27551309.
    10.1186/s12263-016-0524-4
  25. Zaina S; Gonçalves I; Carmona FJ; Gomez A; Heyn H; Mollet IG; Moran S; Varol N; Esteller M. "DNA methylation dynamics in human carotid plaques after cerebrovascular events.". (2015): http://europepmc.org/abstract/med/26088578.
    10.1161/ATVBAHA.115.305630
  26. Tattikota SG; Rathjen T; Hausser J; Khedkar A; Kabra UD; Pandey V; Sury M; et al. "miR-184 Regulates Pancreatic ß-Cell Function According to Glucose Metabolism.". (2015): http://europepmc.org/abstract/med/26152724.
    10.1074/jbc.M115.658625
  27. Christensen GL; Jacobsen ML; Wendt A; Mollet IG; Friberg J; Frederiksen KS; Meyer M; et al. "Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents.". (2015): http://europepmc.org/abstract/med/25828920.
    10.1007/s00125-015-3568-x
  28. Salunkhe VA; Esguerra JL; Ofori JK; Mollet IG; Braun M; Stoffel M; Wendt A; Eliasson L. "Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.". (2015): http://europepmc.org/abstract/med/25627423.
    10.1111/apha.12460
  29. Mollet, I. G.; Malm, H. A.; Wendt, A.; Orho-Melander, M.; Eliasson, L.. "CAMTA1-Calcium-Calmodulin Transcriptional Activator 1, a new player in the regulation of microRNAs and insulin secretion". Diabetologia (2015): https://publons.com/wos-op/publon/10906194/.
  30. Malm, H. A.; Esguerra, J. L. S.; Orho-Melander, M.; Eliasson, L.; Mollet, I. G.. "Identification of novel targets of the miR-212/132 cluster involved in Wnt-signalling and regulation of insulin secretion in the pancreatic beta cell". Diabetologia (2015): https://publons.com/wos-op/publon/10906209/.
  31. Edsfeldt, A.; Duner, P.; Stahlman, M.; Mollet, I. G.; Asciutto, G.; Grufman, H.; Nitulescu, M.; et al. "THE PRO-INFLAMMATORY ROLE OF SPHINGOLIPIDS AND GLYCOSPHINGOLIPIDS IN THE HUMAN ATHEROSCLEROTIC PLAQUE". Atherosclerosis (2015): https://publons.com/wos-op/publon/10906198/.
    10.1016/J.ATHEROSCLEROSIS.2015.04.113
  32. "One in twenty patients with hereditary hemorrhagic telangiectasia report iron treatments precipitate nosebleeds". Angiogenesis (2015): https://publons.com/wos-op/publon/10906199/.
  33. Eliasson, L.; Salunkhe, V. A.; Reinbothe, T.; Mollet, I. G.; Wendt, A.; Vikman, J.. "Mice on high fat diet or normal diet have different metabolic responses to rosuvastatin treatment". Diabetologia (2015): https://publons.com/wos-op/publon/10906197/.
  34. Nicholas, Lisa M.; Valtat, Berengere; Larsson, Nils-Goeran; Abels, Mia; Mollet, Ines G.; Eliasson, Lena; Wierup, Nils; Mulder, Hindrik. "Loss of the Mitochondrial Transcription Factor TFB2M in Pancreatic beta-Cells Leads to Impaired Insulin Secretion and the Development of Diabetes". Diabetes (2015): https://publons.com/wos-op/publon/10906193/.
  35. Shovlin CL; Mollet IG; Giess A; Thomas E; Jones MD; Game L; Govani FS. "P17 Molecular Complexities Identified Through Targeted Genomic Sequencing Of The Hht3 Locus On Chromosome 5". Thorax 69 (2014): A84-A85. http://dx.doi.org/10.1136/thoraxjnl-2014-206260.167.
  36. Sharoyko VV; Abels M; Sun J; Nicholas LM; Mollet IG; Stamenkovic JA; Göhring I; et al. "Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.". (2014): http://europepmc.org/abstract/med/24916378.
    10.1093/hmg/ddu288
  37. Shovlin CL; Govani FS; Mollet IG; Thomas E; Jones MD; Giess A; Game L. "P14 Very High Quality Next-generation Dna Sequencing Data From Human Genomic Dna Samples Stored, And Intermittently Defrosted Over Two Decades". Thorax 69 (2014): A83. http://dx.doi.org/10.1136/thoraxjnl-2014-206260.164.
  38. Shovlin CL; Patel D; Govani FS; Giess A; Jones MD; Game L; Mollet IG. "P15 Directional Next Generation Whole Transcriptome Sequencing Of Primary Human Pulmonary Microvascular Endothelial Cells". Thorax 69 (2014): A83-A84. http://dx.doi.org/10.1136/thoraxjnl-2014-206260.165.
  39. Fadista J; Vikman P; Laakso EO; Mollet IG; Esguerra JL; Taneera J; Storm P; et al. "Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.". (2014): http://europepmc.org/abstract/med/25201977.
    10.1073/pnas.1402665111
  40. Edsfeldt A; Gonçalves I; Grufman H; Nitulescu M; Dunér P; Bengtsson E; Mollet IG; et al. "Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes.". (2014): http://europepmc.org/abstract/med/25035341.
    10.1161/ATVBAHA.114.303414
  41. Esguerra JL; Mollet IG; Salunkhe VA; Wendt A; Eliasson L. "Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.". (2014): http://europepmc.org/abstract/med/25383562.
    10.3390/genes5041018
  42. Reinbothe TM; Safi F; Axelsson AS; Mollet IG; Rosengren AH. "Optogenetic control of insulin secretion in intact pancreatic islets with ß-cell-specific expression of Channelrhodopsin-2.". (2014): http://europepmc.org/abstract/med/25483880.
    10.4161/isl.28095
  43. Malm, H. A.; Berggreen, C.; Orho-Melander, M.; Eliasson, L.; Goransson, O.; Mollet, I. G.. "Dephosphorylation and nuclear translocation of the CREB-regulated transcription co-activator 1 (CRTC1) elevates miR-212 and miR-132 expression in insulin secreting cells". Diabetologia (2014): https://publons.com/wos-op/publon/10906202/.
  44. "P17 Molecular Complexities Identified Through Targeted Genomic Sequencing Of The Hht3 Locus On Chromosome 5". Thorax (2014): https://publons.com/wos-op/publon/10906205/.
    10.1136/THORAXJNL-2014-206260.167
  45. "P15 Directional Next Generation Whole Transcriptome Sequencing Of Primary Human Pulmonary Microvascular Endothelial Cells". Thorax (2014): https://publons.com/wos-op/publon/10906196/.
    10.1136/THORAXJNL-2014-206260.165
  46. "P14 Very High Quality Next-generation Dna Sequencing Data From Human Genomic Dna Samples Stored, And Intermittently Defrosted Over Two Decades". Thorax (2014): https://publons.com/wos-op/publon/10906195/.
    10.1136/THORAXJNL-2014-206260.164
  47. Govani FS; Giess A; Mollet IG; Begbie ME; Jones MD; Game L; Shovlin CL. "Directional next-generation RNA sequencing and examination of premature termination codon mutations in endoglin/hereditary haemorrhagic telangiectasia.". (2013): http://europepmc.org/abstract/med/23801935.
    10.1159/000350208
  48. Salunkhe, V. A.; Andersson, S. A.; Esguerra, J. L. S.; Mollet, I. G.; Wendt, A.; Eliasson, L.. "Regulation of miR-335 expression contributes to orchestrate insulin secretion at the level of exocytosis in insulin secreting INS-1 832/13 cells". Diabetologia (2013): https://publons.com/wos-op/publon/10906208/.
  49. Malm, H. A.; Mollet, I.; Esguerra, J. L. S.; Orho-Melander, M.; Eliasson, L.. "cAMP mediated regulation of miR-212/132 expression in insulin secreting cells acts through CREB-regulated transcription co-activator 1 (CRTC1)". Diabetologia (2013): https://publons.com/wos-op/publon/10906201/.
  50. "Several type 2 diabetes associated variants in genes involved in WNT-signalling interact with dietary fibre intake on type 2 diabetes incidence". Diabetologia (2013): https://publons.com/wos-op/publon/10906207/.
  51. Sharoyko, V. V.; Landin, M.; Mollet, I.; Spegel, P.; Eliasson, L.; Wierup, N.; Mulder, H.. "Deficiency of TFB1M leads to beta cell dysfunction and development of diabetes". Diabetologia (2012): https://publons.com/wos-op/publon/3832194/.
  52. Salunkhe, V. A.; Braun, M.; Esguerra, J. L. S.; Mollet, I.; Wendt, A.; Stoffel, M.; Rorsman, P.; Eliasson, L.. "Influence of miR-375 on electrophysiological properties of voltage-dependent Na+ channels in mouse beta cells and INS1-832/13 cells". Diabetologia (2012): https://publons.com/wos-op/publon/10906203/.
  53. Mollet IG; Ben-Dov C; Felício-Silva D; Grosso AR; Eleutério P; Alves R; Staller R; Silva TS; Carmo-Fonseca M. "Unconstrained mining of transcript data reveals increased alternative splicing complexity in the human transcriptome.". (2010): http://europepmc.org/abstract/med/20385588.
    10.1093/nar/gkq197
  54. Shovlin CL; Angus G; Manning RA; Okoli GN; Govani FS; Elderfield K; Birdsey GM; et al. "Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension.". (2010): http://europepmc.org/abstract/med/20174619.
    10.1371/journal.pone.0009154
  55. Pacheco TR; Coelho MB; Desterro JM; Mollet I; Carmo-Fonseca M. "In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site.". (2006): http://europepmc.org/abstract/med/16940179.
    10.1128/MCB.00350-06
  56. Mollet I; Barbosa-Morais NL; Andrade J; Carmo-Fonseca M. "Diversity of human U2AF splicing factors.". (2006): http://europepmc.org/abstract/med/17042780.
    10.1111/j.1742-4658.2006.05502.x
Preprint
  1. Adrianna M. Bielowka; Fatima S. Govani; Dilip Patel; Maria E Bernabeu-Herrero; Dongyang Li; Micheala A. Aldred; Inês G. Mollet; Claire L Shovlin. "Transcriptome-wide analysis of primary human endothelial cell responses to 1 hour of protein translation inhibition identify nonsense mediated decay targets and a non-codingSLC11A2exon as an acute biomarker". 2023. https://doi.org/10.1101/2023.09.21.558767.
    10.1101/2023.09.21.558767
  2. Maria E Bernabeu-Herrero; Dilip Patel; Adrianna Bielowka; Sindu Srikaran; Patricia Chaves Guerrero; Fatima S Govani; Inês G Mollet; et al. "Heterozygous transcriptional and nonsense decay signatures in blood outgrowth endothelial cells from patients with hereditary haemorrhagic telangiectasia". 2021. https://doi.org/10.1101/2021.12.05.471269.
    10.1101/2021.12.05.471269
Working paper
  1. Bernabeu-Herrero ME; Patel D; Bielowka A; Srikaran S; Guerrero PC; Govani FS; Mollet IG; et al. 2021. "Heterozygous transcriptional and nonsense decay signatures in blood outgrowth endothelial cells from patients with hereditary haemorrhagic telangiectasia". https://doi.org/10.1101/2021.12.05.471269.
  2. Ana Marta de Jesus Gomes de Matos; Inês de Sousa Lima; Inês Mollet; Maria Teresa Blazquez-Sanchez; Fátima Martins; Maria Joa~o Menezes; Alice Martins; et al. 2018. "Digging into the antidiabetic activity of 8-¿-D-Glucosylgenistein: optimized synthesis, chronic treatment effects in DIO mice, and mechanisms of action". http://hdl.handle.net/10451/42532.

Other

Dataset
  1. Mollet, Inês. ExonMine - Alternative Splicing Database. www.imm.fm.ul.pt/exonmine.
Other output
  1. Pre-diabetes linked microRNA miR-193b-3p targets PPARGC1A and increases lipid accumulation in hepatocytes: potential biomarker of fatty liver disease. 2021. Inês Guerra Mollet; Maria Paula Macedo. https://doi.org/10.1101/2021.01.22.427820.
    10.1101/2021.01.22.427820
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/03/08 PROTEÓMICA DO DUODENO HUMANO NA DIABETES TIPO 2 REVELA ALTERAÇÕES DE DINÂMICA ESTRUTURAL CELULAR 21° Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (Algarve, Portugal)
2020/12/16 Profiling the Humoral Response to Limb Remote Ischemic Conditioning BioSeminars
UCIBIO/FCT-NOVA (Caparica, Portugal)
2020/11/20 Limb Remote Ischemic Conditioning - Blood Profiling in Search of Neuroprotective Signatures Casual Friday with Science
CEDOC - NOVA Medical School (Lisbon, Portugal)
2018/12/14 The role of circulating microRNAs in Metabolic Diseases Casual Friday with Science
CEDOC - NOVA Medical School
2018/11/23 The role of circulating microRNAs in Lipid Metabolism - Implications for Obesity 22° Congresso Portugue^s de Obesidade - Encontro com o Especialista
SPEO - Sociedade Portuguesa para o Estudo da Obesidade (Lisbon, Portugal)
2017/12/06 From Liquid Biopsies to Systems Biomedicine - Tracking networks targeted by circulating microRNAs in metabolic diseases Computational Biology and Bioinformatic Seminars
Instituto de Medicina Molecular (Lisbon, Portugal)
2017/09/12 Nervous system signalling in the diabetic gut – Links between disrupted nutrient sensing and neurotrophic and GABAergic signalling in pre-diabetes Annual Meeting - Gut Brain Axis Symposium
British Society for Neuroendocrinology (Nottingham, United Kingdom)
2017/03/17 "Apresentacao do Estudo Clinico BIOMET – Biomarcadores em exosomas na Remissao da Diabetes Tipo 2 em Cirurgia Metabolica" (Clinical study BIOMET – Exosome Biomarkers of Type 2 Diabetes Remission after Metabolic Surgery) Clinical Meeting - As Espedialidades Aliadas na Cirurgia Baria´trica e Metabo´lica
Serviço Integrado de Cirurgia Bariátrica e Metabólica - British Hospital (Torres de Lisboa) (Lisbon, Portugal)
2015/09/17 CAMTA1 - Calcium-Calmodulin Transcriptional Activator 1, a new player in the regulation of microRNAs and insulin secretion 51st European Association for the Study of Diabetes (EASD) Meeting 2015
EAGE Publications BV (Stockholm, Sweden)

Supervision

Thesis Title
Role		 Degree Subject (Type)
Institution / Organization
2026/01/19 - Current Effect of lipotoxicity on lysosome dynamics and regulation of multivesicular bodies in intestinal mucosa, in the context of type 2 diabetes
Supervisor
 Biochemistry Projects (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/09/01 - Current Analysis of post translational modifications in duodenal proteome in type 2 diabetes
Supervisor
 Masters in Biqchemistry (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/09/01 - Current Effect of dietary saturated fatty acids on intestinal mucosa stability in type 2 diabetes context
Supervisor
 Masters in Biochemistry (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/01/15 - Current Investigating cytoprotection by the dietary isoflavone Biochanin A against palmitate cytotoxicity in a human neural cell line - relevance to peripheral neural system in type 2 diabetes.
Supervisor
 Biochemistry Project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2026/03/09 - 2026/04/17 Efeito da lipotoxicidade de acidos gordos saturados a nível de stress oxidativo num modelo células da mucosa intestinal de suino, no contexto da diabetes tipo 2, e efeito da quercetina como antioxidante
Supervisor of RAQUEL CARDOSO ALVES
 Mestrado Integrado em Medicina da Universidade do Algarve - MEE (Scientific initiation)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associate Laboratory Institute for Health and Bioeconomy, Portugal
2022/09/01 - 2023/12/07 Investigating the effect of dietary lignans on a model of enteric neurons as potential nutraceutical candidates to induce type 2 diabetes remission
Supervisor
 Masters in Biochemistry for Health (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/02/01 - 2022/06/30 Investigating effects of the dietary phytochemical matairesinol on palmitate induced cell damage in a human neural cell line
Supervisor of Raquel Nobrega
 Projecto de Bioquímica (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/02/01 - 2022/06/30 Investigating effects of the dietary phytochemical coumestrol on palmitate induced cell damage in a human neural cell line
Supervisor of Marlon Martins Cavalcante
 Biochemistry Project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/09/01 - 2021/11/26 Investigating Cellular and Molecular Neuroendocrine Signalling in the Diabetic Gut
Supervisor of Miguel Ângelo de Freitas Mira
 Master in Molecular Genetics and Biomedicine (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/02/01 - 2021/07/19 CONDICIONAMENTO ISQUÉMICO REMOTO
Co-supervisor of Catarina Alexandra Morais Fernandes da Costa Bento
 Biochemistry Project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/01/13 - 2020/07/08 Condicionamento isquémico remoto (CIR) em AVC isquémico – avaliação dos mecanismos moleculares e celulares
Co-supervisor of José Maria Fonseca Falcão
Biochemistry Project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/03/01 - 2016/02/29 Transcriptional Regulation of miRNA-212 and miRNA-132 and their fine-tuning function of beta cell insulin secretion
Co-supervisor of Helena Malm
 PhD Biomedical Sciences (PhD)
Lunds Universitet, Sweden

Event organisation

Event name
Type of event (Role)		 Institution / Organization
2026/03/01 - 2026/04/15 EXPO - FCT 2026 - Stand organization - “Gatekeepers of the Gut: Cells at Work in Health and Disease” (2026/04/15 - 2026/04/15)
Festival (Other)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/04/01 - 2025/04/30 EXPO - FCT 2025 - Stand organization - As células do cérebro e do intestino (2025/04/30 - 2025/04/30)
Festival (Other)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/04/01 - 2024/04/10 EXPO - FCT 2024 - Stand organization and management - As células do cérebro e do intestino (2024/04/10 - 2024/04/10)
Festival (Other)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/04/01 - 2023/04/19 EXPO - FCT 2023 - Stand organization - As células do cérebro e do intestino (2023/04/19 - 2023/04/19)
Festival (Other)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/02/29 - 2020/02/29 CEDOC - LYSOCIL 2020 Open Day (2020/02/29 - 2020/02/29)
Festival (Co-organisor)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2018/09/28 - 2018/09/28 European Researchers’ Night - Noite Europeia dos Investigadores (2018/09/28 - 2018/09/28) EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Belgium
2016/10/29 - 2016/10/29 CEDOC Open Day (2016/10/29)
Other (Other)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Event participation

Activity description
Type of event		 Event name
Institution / Organization
2026/02/24 - 2026/02/26 1st INFLAMomx Meeting - WG1 Leader - Split (Croatia)
Meeting
 1st INFLAMomx Meeting
2025/09/29 - 2025/09/29 First management Committee Meeting of COST Action CA24166 “Pan- European Network for Inflammaging: A Multi-omics Integration Approach” (INFLAMomx) COST premises, Brussels (Belgium)
Meeting
 First management Committee Meeting of COST Action CA24166
European Cooperation in Science and Technology, Belgium
2025/03/06 - 2025/03/08 21º Congresso Português da Diabetes
Congress
 21º Congresso Português da Diabetes
Sociedade Portuguesa de Diabetologia, Portugal
2024/10/24 - 2024/10/26 XXII National Congress of Biochemistry - Poster - Proteomics of human duodenom in type 2 diabetes - insights into intestinal malfunction
Congress
 XXII National Congress of Biochemistry. - Next-Gen Biochemical Challenges Across Borders
Universidade de Aveiro, Portugal
2024/10/02 - 2024/10/04 BioData.pt All Hands Meetings with Systems Biology Community
Meeting
 BioData.pt All Hands Meeting
BioData.pt, Portugal
2024/09/01 - 2024/09/05 ASSOCIATION FOR THE ADVANCEMENT OF INDUSTRIAL CROPS - Medicinal and Nutraceutical Plants- Poster - Dietary Lignans as Potential Nutraceuticals against Neural Damage Induced by High Fat 35th Annual Conference & Meeting
Association for the Advancement of Industrial Crops, United States
2023/09/03 - 2023/09/03 British Society for Neuroendocrinology Annual Meeting - Poster - Profiling duodenal enteric nervous system typology changes in prediabetes and type 2 diabetes in human and mouse
Meeting
 British Society for Neuroendocrinology Annual Meeting - Exeter 2023
2022/11/11 - 2022/11/12 2º Encontro Internacional da Sociedade Portuguesa de Fisiologia – Coimbra 2022
Meeting
 2nd International Meeting SPF - Coimbra 2022
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2022/02/17 - 2022/02/17 Comparative Anatomy and Histology of Laboratory Animals, Rodent Perfusion & Special Procedures
Workshop
 Necropsy Workshop
Instituto Gulbenkian de Ciência, Portugal
2022/01/18 - 2022/01/20 Macro Scripting in ImageJ - COLIfe & FCUL Course
Workshop
 Macro Scripting in ImageJ
2020/02/09 - 2020/02/14 Correlated Multimodal Imaging in Life Sciences, COMULIS - A practical approach to correlative Light and Electron Microscopy
Workshop
 COST Action - COMULIS CLEM Training School
Instituto Gulbenkian de Ciência, Portugal
2018/03/09 - 2018/03/11 14.º Congresso Português de Diabetes - Poster - Plasma mir-193b-3p could be a biomarker for pre-diabetes progression or regression
Congress
 14° Congresso Português de Diabetes 2018
Sociedade Portuguesa de Diabetologia, Portugal
2017/03/10 - 2017/03/12 13º Congresso Português da Diabetes - Poster - Study of regulation of gene expression by circulating microRNAs (c-miRNAs) previously associated with diabetes and NAFLD reveals convergence of action on insulin regulatory mechanisms and its metabolism
Congress
 13° Congresso Portugue^s de Diabetes 2017
2015/10/15 - 2015/10/15 Poster - One in twenty patients with hereditary hemorrhagic telangiectasia report iron treatments precipitate nosebleeds
Conference
 11th International HHT Scientific Conference, Oct 2015 Angiogenesis
2015/09/14 - 2015/09/18 Poster - Identification of novel targets of the miR-212/132 cluster involved in Wnt-signalling and regulation of insulin secretion in the pancreatic beta cell
Congress
 European Association for the Study of Diabetes (EASD) Congress 2015
2015/09/14 - 2015/09/18 Poster - Mice on high fat diet or normal diet have different metabolic responses to rosuvastatin treatment
Congress
 European Association for the Study of Diabetes (EASD) Congress 2015
2014/09/19 - 2014/09/21 Poster - CAMTA1 - Calcium-Calmodulin Transcriptional Activator, a new player in the regulation of microRNAs and insulin secretion
Meeting
 European Association for the Study of Diabetes - Islet Study Group Meeting (ISG-EASD) 2014
2014/09/15 - 2014/09/19 Poster - Dephosphorylation and nuclear translocation of the CREB-regulated transcription co-activator 1 (CRTC1) elevates miR-212 and miR-132 expression in insulin secreting cells
Congress
 European Association for the Study of Diabetes (EASD) Congress 2014
2013/09/27 - 2013/09/29 Poster - A calmodulin-binding transcription activator modulates miR-212 and miR-132 expression and insulin secretion in INS-1 832/13 ß-cells
Meeting
 European Association for the Study of Diabetes - Islet Study Group Meeting (ISG-EASD) 2013
2013/09/27 - 2013/09/28 Poster - Bone morphogenetic protein 4 inhibits insulin secretion by regulation of Calbindin expression
Meeting
 European Association for the Study of Diabetes -.Islet Study Group Meeting (ISG-EASD) – 2013
2013/09/23 - 2013/09/27 Poster - cAMP mediated regulation of miR- 212/132 expression in insulin secreting cells acts through CREB-regulated transcription co-activator 1 (CRTC1).
Congress
 European Association for the Study of Diabetes (EASD) Congress 2013
2013/09/23 - 2013/09/27 Poster - Regulation of miR-335 expression contributes to orchestrate insulin secretion at the level of exocytosis in insulin secreting INS- 1 832/13 cells
Congress
 European Association for the Study of Diabetes (EASD) Congress 2013
2013/09/23 - 2013/09/27 Poster - Several type 2 diabetes associated variants in genes involved in WNT- signalling interact with dietary fibre intake on type 2 diabetes incidence
Congress
 European Association for the Study of Diabetes (EASD) Congress 2013
2012/10/01 - 2012/10/05 Poster - Deficiency of TFB1M leads to beta cell dysfunction and development of diabetes
Congress
 European Association for the Study of Diabetes (EASD) Congress 2012
2011/10/23 - 2011/10/26 Poster - Influence of miR-375 on electrophysiological properties of voltage-dependent Na+ channels in mouse beta cells
Meeting
 Beta Cell workshop 2011, “Programming Beta Cell Development, Impairment and Regeneration
2009/06/22 - 2009/07/02 Poster - ExonMine: Unconstrained mining for exons and alternative splicing
Conference
 8th European Conference on Computational Biology (ECCB) 2009
2009/02/05 - 2009/02/07 Poster - Genome-wide bioinformatics search for cancer- associated splicing misregulation
Workshop
 International Workshop on High Throughput Technologies for Alternative Splicing 2009
2009/02/05 - 2009/02/07 Poster - Exploring Cellular Codes of Splicing Regulation Using Splicing-Sensitive Microarrays
Workshop
 International Workshop on High Throughput Technologies for Alternative Splicing 2009

Jury of academic degree

Topic
Role		 Candidate name (Type of degree)
Institution / Organization
2025/07/15 Estudo dos efeitos do ácido oleico, ácido palmítico e matairesinol na capacidade de regulação do stress oxidativo numa linha celular neuronal
Supervisor
 Matilde Boavista (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/07/08 Sequence Analysis and Expression of a Toxin from the Venom of the lesser weever fish Echiichthys vipera
(Thesis) Main arguer
 Carolina Pinto Fonseca (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/07/08 Estudo da proteína DHRS4 numa linha celular neuronal exposta a lipotoxicidade no contexto de Diabetes Tipo 2
Supervisor
 Eva Hryshyna (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/07/07 The Role of Liver-Derived Extracellular Vesicles in Modulating Skeletal Muscle Function in Prediabetic Conditions
(Thesis) Main arguer
 Luísa Arruda Nunes (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/07/07 CONSTRUCTION OF S. pneumoniae MUTANTS TO STUDY THE ROLE OF MurM CONSERVED RESIDUES IN ß-LACTAM RESISTANCE
(Thesis) Main arguer
 Adriana Isabel Leal Gouveia (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/07/08 Avaliação da viabilidade celular e agregação de GRSF1 em alterações metabólicas
(Thesis) Main arguer
 Mariana Pita (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/07/07 Characterization of Tight Junctions in the gastrointestinal tract and blood-brain-barrier in an animal model of systemic inflammation
(Thesis) Main arguer
 Luisa Klut (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/07/05 Biochemical assessment of ribonucleoprotein complexes (RNP) and succination-induced effects by CLIP
(Thesis) Main arguer
 Licinia Sarmento (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/07/05 Avaliação da acumulação patológica de fumarato na modificação pós-traducional e localização subcelular de RBPs em ARPE-19
(Thesis) Arguer
 Bruno Carregosa (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/05/25 METABOLIC DYSFUNCTION IN OBSTRUC- TIVE SLEEP APNEA: IS THERE A ROLE FOR THE LIVER?
(Thesis) Arguer
 Joana Leandro Fernandes (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/07/17 From a Multitarget Antidiabetic Glycosyl Isoflavone towards New Molecular Entities against Diabetes and Alzheimer’s disease: Generation of Lead Series and Target Assessment
Thesis Member
 Ana Marta de Jesus Gomes de Matos (PhD)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Association member

Society Organization name Role
2024/10/03 - Current ELIXIR - Metabolomics Community Member
2024/09/26 - Current ELIXIR - Systems Biology Community Member
2024/09/23 - Current ELIXIR - Food and Nutrition Community https://elixir-europe.org/ Member
2023/06/28 - Current BioData.pt - Federated Human Data Community Member
2022/09/01 - Current BioData.pt "Systems Microbial Biotechnology and Biology Community" Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2025/05/22 - Current Exercise and Diabetes Biochemistry of Sports and Exercise (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2026/02/02 - 2026/02/06 Redox Signatures of the Gut: How Fats and Phytoestrogens Shape Metabolic Function and Type 2 Diabetes Risk Técnicas Biomoleculares II Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
2026/01/26 - 2026/01/30 "Redox Signatures of the Gut: How Fats and Phytoestrogens Shape Metabolic Function and Type 2 Diabetes Risk" Pra´ticas Laboratoriais Integradas II Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
2025/01/20 - 2025/02/28 Biochemistry Project Biochemistry Project Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/01/27 - 2025/02/13 Integrated Laboratory Practicals II Integrated Laboratory Practicals II (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/01/27 - 2025/02/13 Biomolecular Techniques II Biomolecular Techniques II (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/01/30 - 2024/02/02 Integrated Laboratory Practicals II Masters in Biochemistry for Health (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/11/01 - 2023/12/31 Biochemistry of Food Biochemistry of Food (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/09/13 - 2023/11/20 Food Chemistry and Biochemistry (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/10/09 - 2023/11/09 Biomolecular Techniques I Masters in Biochemistry (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/05/12 - 2021/05/12 Stroke and Vascular dementia PhD Health Sciences - Curricular Unit - Chronic Diseases and Aging Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014/11/05 - 2014/12/16 Problem Based Learning, Molecular Medicine Module BIMA51 (Faculty of Medicine, Lund University. Molecular Medicine (Bachelor) Lunds Universitet, Sweden

Mentoring / Tutoring

Topic Student name
2018/01/08 - 2018/01/26 Biomedicine PhD Program, Project Development course (NOVA Medical School) Five Students