Ester Sofia Teixeira Benfeito (FF11-B5DB-BA39)

Curriculum Vitae

Ester Sofia Teixeira Benfeito

Sofia Benfeito (SB) graduated in Chemistry in 2010 at Faculty of Sciences of University of Porto (FCUP) and received her M.Sc. in Chemistry in 2012 in the same institution. In July 2018, she completed her Ph.D. in Pharmaceutical Sciences, Toxicology speciality, at the Faculty of Pharmacy of the University of Porto, which was titled as European Doctorate. Her Ph.D. thesis was focused on the design and development of multi-target agents based on naturally occurring scaffolds for neurodegenerative diseases, such as Alzheimer's (AD). During her Ph.D., she improved and solidified knowledge related with the synthesis and structural characterization of bioactive compounds. She also acquired experience in biological screenings in cell-based and cell free systems (e.g.: antioxidant activity, cytotoxicity, enzyme inhibition, permeability studies), in mitochondrial uptake assays in Rat Liver Mitochondria and in monitoring bioenergetics of mitochondria and live cells in real time using Seahorse XFe96 Extracellular Flux Analyzer. The work developed was considered a major breakthrough and she was also internationally awarded by Paul Ehrlich European MedChem Network-PhD Label (Italy, 2019). Currently, as Junior Researcher, she is engaged in the synthesis of new chemical entities for phenotypic/target-based screenings and in the optimization of lead compounds to develop pharmacologically viable candidates. SB is the Principal Investigator of an Awarded FCT Project, which started in March 2023, "DeFend - De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators" (2022.04633.PTDC),project with the collaboration of Dr. António Currais (Salk Institute, USA), and the Co-Principal Investigator of the Awarded FCT Project, from February 2022 to July 2023, "NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure" (EXPL/BIA-BQM/0492/2021), project with the collaboration of Professor Andrea Mattevi (UniPV, Italy). SB participated as a Researcher in other numerous funded R&D projects, from which resulted 31 peer-reviewed publications in international high impact factor journals (10 as first author, 2 as corresponding author, 86% in Q1), 7 book chapters, 92 communications in Poster, 47 Oral communications, as well as 35 abstracts in conference proceedings. The citation count from Scopus is a total of 420 resulting in an h-index of 10. Moreover, she was also co-inventor of 1 international patent (PCT/IB2017/056412; US20190248816), which the commercial exploitation was licensed to the MitoTAG spin-off company (2017). SB attended with full grants 3 international training schools: the European School of Medicinal Chemistry (Italy, 2016), the MuTaLig COST Action CA15135 Multi-Targeting Biophysical Training School (Germany, 2018) and Summer School in Pharmaceutical Analysis (Italy 2021). In addition to her research activities, she participated as invited Professor in Medicinal Chemistry and Bioorganic Chemistry classes and supervised several students in PhD Thesis, Project (Chemistry and Biochemistry BSc) and Dissertation (Chemistry MSc) classes (18 students in total). Over the last 5 years, SB was actively involved in science dissemination activities and established national/international collaborations with 23 groups that can add value to her current research activities.

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Identificação

Identificação pessoal

Nome completo: Ester Sofia Teixeira Benfeito

Nomes de citação

Benfeito, Ester
Benfeito, S.
Benfeito, Sofia

Identificadores de autor

Ciência ID: FF11-B5DB-BA39
ORCID iD: 0000-0001-9645-8152
AuthenticusID: ID: R-001-VKN
Google Scholar ID: Sofia Benfeito
Researcher Id: N-9418-2017
Scopus Author Id: 55151147600

Endereços de correio eletrónico

ester.benfeito@fc.up.pt (Profissional)

Moradas

Faculdade de Ciências da Universidade do Porto. Rua do Campo Alegre s/n, 4169-007, Porto, Porto, Portugal (Profissional)

Websites

https://drugdiscoveryup.pt/ (Profissional)
https://pt.linkedin.com/in/sofia-benfeito-01a8a45b (Rede social)
https://www.researchgate.net/profile/Sofia-Benfeito (Rede social)
https://www.scopus.com/authid/detail.uri?authorId=55151147600 (Profissional)

Domínios de atuação

Ciências Exatas - Química - Química Orgânica
Ciências Médicas e da Saúde - Medicina Básica - Toxicologia
Ciências Médicas e da Saúde - Medicina Básica - Química Médica
Ciências Médicas e da Saúde - Medicina Clínica
Ciências Médicas e da Saúde - Ciências da Saúde - Cuidados de Saúde e Serviços

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Francês	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)

Formação

	Grau	Classificação
2021/09/22 - 2021/09/24 Frequentou	Summer School in Pharmaceutical Analysis (Outros) Especialização em Analytical methods to achieve efficiency in the hit-to-lead process Università degli Studi di Bologna, Itália
2018/12/05 - 2018/12/07 Frequentou	3rd MuTaLig Training School - Cost Action multi-targeting biophysical training school (Outros) Fraunhofer-Verbund IUK-Technologie, Alemanha
2014/03/01 - 2018/07/16 Concluído	PhD in Pharmaceutical Sciences (Doutoramento) Especialização em Toxicology Specialty Universidade do Porto Faculdade de Farmácia, Portugal "Design and development of multi-target agents for neurodegenerative diseases" (TESE/DISSERTAÇÃO)	Unanimously approved
2016/06/26 - 2016/07/01 Frequentou	Training School - 36 th Edition of European School of Medicinal Chemistry (ESMEC) (Outros) Campus “Collegi del Colle e Tridente”, Itália
2010/09/01 - 2012/10/03 Concluído	MSc in Chemistry (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal ""Desenvolvimento de novos antioxidantes lipofílicos baseado no ácido cinâmico"" (TESE/DISSERTAÇÃO)	16/20
2006/09/01 - 2010/07/13 Concluído	1st Degree in Chemistry (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal "Quality control of port wine and study of the evolution of the levels of calcium, potassium and copper along the aging process by atomic absorption spectroscopy." (TESE/DISSERTAÇÃO)	13/20

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2024 - Atual	Investigador Contratado (Investigação)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2018 - Atual	Investigador visitante (Investigação)	REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2018/12/01 - 2024/03/07	Investigador Contratado (Investigação)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2019/09/02 - 2020/03/06	Investigador visitante (Investigação)	Università degli Studi Magna Graecia di Catanzaro, Itália
	Universidade do Porto Centro de Investigação em Química, Portugal
2014/10/06 - 2017/09/29	Investigador visitante (Investigação)	Universidade de Santiago de Compostela Facultad de Farmacia, Espanha

2017/05/01 - 2017/08/31	Investigador visitante (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2011/03/02 - 2011/11/02	Estagiário de Investigação (Investigação)	Universidade do Porto Centro de Investigação em Química, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2018/05/16 - 2018/12/01	Research grant in the project: "Sustainable Advanced Materials (SAM)¿ (NORTE-01-0145-FEDER-000028)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal (...)
2014/03/01 - 2018/03/01	PhD student, FCT Grant (SFRH/BD/99189/2013)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal (...)
2012/11/02 - 2013/11/02	Research grant in the project: "NanoPest - Nanotecnologia Aplicada aos Pesticida (PTDC/AGR-AAM/105044/2008)	Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2011/12/05 - 2012/03/06	Erasmus training period	Universidade de Santiago de Compostela Facultad de Farmacia, Espanha

Projetos

Bolsa

	Designação	Financiadores
2018/05/16 - 2018/12/01	Sustainable Advanced Materials (SAM) NORTE-01-0145-FEDER-000028 Bolseiro de Mestrado Universidade do Porto Faculdade de Ciências, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Fundação para a Ciência e a Tecnologia Concluído
2014/03 - 2018/02	Design and development of multi-target agents for neurodegenerative diseases SFRH/BD/99189/2013 Bolseiro de Doutoramento	Fundação para a Ciência e a Tecnologia Concluído
2012/11/02 - 2013/11/02	NanoPest - Nanotecnologia Aplicada aos Pesticidas PTDC/AGR-AAM/105044/2008 Bolseiro de Mestrado Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2022/03/11 - Atual	PT-OPENSCREEN - NORTE-01-0145-FEDER-085468: “Infraestrutura Nacional para a Química Biológica e Genética” NORTE-01-0145-FEDER-085468 Investigador Pós-doutorado Universidade do Porto, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal Universidade do Minho, Portugal Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Em curso
2024 - 2027	IMPULSE: IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN 101132028 Investigador Pós-doutorado Universidade do Porto Faculdade de Ciências, Portugal	European Research Executive Agency Em curso
2019/12/01 - 2022/01/31	COMT4BRAIN: Development of centrally-active and safe catechol O-methyltransferase inhibitors POCI-01-0145-FEDER-029164 Investigador Pós-doutorado Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/12/01 - 2019/11/29	SkinSHIELD 2: Redox-active phytochemicals triggering mitochondrial hormesis: developing a new generation of cosmetic active ingredients POCI-01-0145-FEDER-028607 Investigador Pós-doutorado Universidade do Porto Faculdade de Ciências, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Outro

	Designação	Financiadores
2023/03/10 - Atual	DeFend: De-ironing Friedreich¿s Ataxia with innovative mitochondria-targeted chelators 2022.04633.PTDC Investigador responsável Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Ciências, Portugal Salk Institute for Biological Studies, Estados Unidos	Fundação para a Ciência e a Tecnologia Em curso
2023/03/10 - Atual	MitoTARGET4AD: Improving Nature for a Novel Disruptive Treatment for Alzheimer's Disease 2022.15117.CBM Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal Université de Montpellier, França	Fundação para a Ciência e a Tecnologia Concluído
2022/01/01 - Atual	euroTool4ALS: Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis PTDC/BTM-ORG/0055/2021 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - Atual	Plurianual Funding of the Associated Laboratory Institute of Molecular Sciences LA/P/0056/2020 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020/01/01 - Atual	CIQUP - Financiamento Plurianual da Unidade de I&D CIQUP - Centro de Investigação em Química da Universidade do Porto UIDB/00081/2020 Post-Doc Team member Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/02/01 - 2023/07/31	NOXIous- Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure EXPL/BIA-BQM/0492/2021 Co-Investigador Responsável (Co-IR) Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Ciências, Portugal Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie L. Spallanzani, Itália	Fundação para a Ciência e a Tecnologia Concluído
2022/01/01 - 2023/06/30	Role of mitochondrial-thiol homeostasis in neurodegeneration: implication for amyotrophic lateral sclerosis EXPL/BTM-TEC/1407/2021 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2022/07/01 - 2023/06	MitoBOOST v2.0 - Prova de Conceito para o Uso de Polifenóis Dirigidos à Mitocôndria para Tratar a Doença do Fígado Gordo Não-Alcoólico 181226 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Concluído
2018/07/01 - 2022/05/01	Mito4ALS -Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype POCI-01-0145-FEDER-029391 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/01/01 - 2022/05/01	ABFish -Development of new antibiotics for aquaculture POCI-01-0145-FEDER-028397 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/06/06 - 2021/06/05	BIOFILM-Development of novel biocide solutions for effective biofilm control POCI-01-0145-FEDER-030219 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/07 - 2020/10	Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig) CA COST Action CA15135 OC-2016-2-21500 Post-Doc Team member	European Union Concluído
2015/09/01 - 2018/02/28	TOX-OER - Learning Toxicology through Open Educational Resources 2015-1-ES01-KA203-015957 Colaboration Universidade do Porto Faculdade de Farmácia, Portugal	Erasmus Plus Concluído
2017 - 2017	MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria PTDC/DTP-FTO/2433/2014 Bolseiro de Doutoramento Universidade do Porto Faculdade de Ciências, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016 - 2016	Centro de Investigação em Química da Universidade UID/QUI/00081/2013 Bolseiro de Doutoramento Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2015 - 2015	Development of functional materials NORTE-07-0124-FEDER-000065 Bolseiro de Doutoramento Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2014/03/01 - 2014/12/31	Projecto Estratégico - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013 Bolseiro de Doutoramento Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013 - 2014	Projecto Estratégico – UI81-2013-2014 PEst-C/QUI/UI0081/2013 Bolseiro de Doutoramento Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2012	Environmentally friendly active films based on chitosan PP_IJUP2011 208 Desenvolvimento técnico Universidade do Porto, Portugal	Universidade do Porto Concluído
2012 - 2012	Formulação de uma bebida funcional à base de extrato natural purificado de Spergularia rubra PP-IJUP2011-UNICER- 84 Desenvolvimento técnico Universidade do Porto, Portugal	Universidade do Porto Faculdade de Ciências Banco Santander Portugal Concluído
2011 - 2011	Fine-tuning the hydrophobicity of natural antioxidants: development of innovative mitochondria-targeted antioxidants based on benzoic acid scaffold PP_IJUP2011 209 Desenvolvimento técnico Universidade do Porto, Portugal	Universidade do Porto Concluído

Produções

Publicações

Artigo em revista	Amorim, R.; Magalhães, C.; Benfeito, S.; Cagide, F.; Tavares, L.; Santos, K.; Borges, F.; et al. "Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism". Biochem Pharmacol. (2024): https://pubmed.ncbi.nlm.nih.gov/38036191/. Publicado • 10.1016/j.bcp.2023.115953 Martins, D.; Gil-Martins, E.; Cagide, F.; Soares, P.; Benfeito, S.; Fernandes, C.; Silva, R.; Borges, F.. "Unravelling the in vitro toxicity profile of psychedelic 2C phenethylamines and their N-benzylphenethylamine (NBOMe) analogues". Archives Toxicology (2023): https://www.mdpi.com/1424-8247/16/8/1158. Publicado • https://doi.org/10.3390/ph16081158 Fernandes, C.; Benfeito, S.; Silva, T.; Sardão, V.; Silva, R.; Oliveira, P. J.; Borges, F.; et al. "Derisking nitrocatechols: a structure-property-toxicity study of tolcapone, entacapone and derivatives thereof". RSC Adv. (2023): Submetido Cátia Silva ; Inês Simões; Carlos Fernandes; Benfeito, S.; M. Wieckowski; Pedro Soares; Fernanda Borges. "Development of a screening cascade to evaluate the lipophilicity, solubility and interaction with physiological membranes of mitochondriotropic antioxidants in early drug discovery projects". Anal. Chem. (2023): Submetido José Teixeira; C. Carreira; Fernando Cagide; A. Barbosa; R. Amorim; P.J. Oliveira; Borges, F.; et al. "Mitochondria-targeted phenolic antioxidants AntiOxBEN2 and AntiOxCIN4 differentially impact energy metabolism in human dermal fibroblasts.". Metabolism (2023): Submetido Amorim, R.; Chavarria, D.; Teixeira, J.; Benfeito, S.; Soares, P.; Cagide, F.; Borges, F.; Oliveira, P. J.. "Decreasing the Burden of Non-Alcoholic Fatty Liver Disease: from Therapeutic Targets to Drug Discovery Opportunities". Med. Res. Rev. (2023): Aceite para publicação Costa, Inês; Barbosa, Daniel José; Silva, Vera; Benfeito, Sofia; Borges, Fernanda; Remião, Fernando; Silva, Renata. "Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases". Pharmaceutics 15 5 (2023): 1369. http://dx.doi.org/10.3390/pharmaceutics15051369. Publicado • 10.3390/pharmaceutics15051369 Barbosa, J.; Pinto, M.; Fernandes, C.; Benfeito, S.; Mendes, R.; Remião, F.; Borges, F.; Braga, S.; Paz, F.. "Coordination Polymers as Multi-Drug Delivery Systems". ACS Appl. Mater. Interfaces (2023): Submetido Costa, I.; Barbosa, D.; Benfeito, S.; Silva, V.; Chavarria, D.; Borges, F.; Remião, F.; Silva, R.. Autor correspondente: Benfeito, S.. "Molecular mechanisms of ferroptosis and their involvement in brain diseases". Pharmacology & Therapeutics (2023): 108373. http://dx.doi.org/10.1016/j.pharmthera.2023.108373. Publicado • 10.1016/j.pharmthera.2023.108373 Chavarria, D.; Borges, A.; Benfeito, S.; Sequeira, L.; Ribeiro, M.; Oliveira, C.; Borges, F.; Simões, M.; Cagide, F.. "Phytochemicals and quaternary phosphonium ionic liquids: connecting the dots to develop a new class of antimicrobial agents". J. Adv. Res. 23 (2023): https://pubmed.ncbi.nlm.nih.gov/36822390/. Publicado • 10.1016/j.jare.2023.02.004 Benfeito, S.; Fernandes, C.; Chavarria, D.; Barreiro, S.; Cagide, F.; Sequeira, L.; Teixeira, J.; et al. "Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks". Journal of Medicinal Chemistry 66 3 (2023): 1835-1851. http://dx.doi.org/10.1021/acs.jmedchem.2c01630. Publicado • 10.1021/acs.jmedchem.2c01630 Benfeito, S.; Chavarria, D.; Soares, P.; Lima, C.; Garrido, J.; Soares-da-Silva, P.; Remião, F.; Borges, F.; Oliveira, PJ.. "Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor". Eur. J. Med. Chem. 243 (2022): 114740. https://www.sciencedirect.com/science/article/pii/S0223523422006420. Publicado • 10.1016/j.ejmech.2022.114740 Amorim, R.; Benfeito, S.; Simões, I.; Borges, F.; Oliveira, P.J.. "Mitochondria-targeted antioxidant AntiOxCIN4 improved liver steatosis in Western Diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems". Redox Biology (2022): https://pubmed.ncbi.nlm.nih.gov/35863265/. Publicado • 10.1016/j.redox.2022 Joana Reis; Carlos Fernandes; Hoda Salem; Marta Maia ; Cláudia Tomé; Benfeito, S.; José Teixeira; et al. "Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties". Eur. J. Med Chem. (2022): https://www.sciencedirect.com/science/article/pii/S0223523422004093. Publicado • 10.1016/j.ejmech.2022.114507 Catalano, Raffaella; Procopio, Francesca; Chavarria, Daniel; Benfeito, Sofia; Alcaro, Stefano; Borges, Fernanda; Ortuso, Francesco. "Molecular Modeling and Experimental Evaluation of Non-Chiral Components of Bergamot Essential Oil with Inhibitory Activity against Human Monoamine Oxidases". Molecules 27 8 (2022): 2467. http://dx.doi.org/10.3390/molecules27082467. Publicado • 10.3390/molecules27082467 Mariana Castelôa; Beatriz Moreira-Pinto; Sofia Benfeito; Fernanda Borges; Bruno M. Fonseca; Irene Rebelo. "In Vitro Effects of Mitochondria-Targeted Antioxidants in a Small-Cell Carcinoma of the Ovary of Hypercalcemic Type and in Type 1 and Type 2 Endometrial Cancer". Biomedicines 10 4 (2022): 800-800. https://doi.org/10.3390/biomedicines10040800. Publicado • 10.3390/biomedicines10040800 Ricardo Amorim; Ludgero C. Tavares; Rui F. Simões; Pedro Soares; Fernando Cagide; Sofia Benfeito; Inês Baldeiras; et al. "Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage". Free Radical Biology and Medicine 179 (2022): 119-132. http://dx.doi.org/10.1016/j.freeradbiomed.2021.12.304. Publicado • 10.1016/j.freeradbiomed.2021.12.304 Carlos Fernandes; Afonso J. C. Videira; Caroline D. Veloso; Sofia Benfeito; Pedro Soares; João D. Martins; Beatriz Gonçalves; et al. "Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis". Biomolecules 11 11 (2021): 1605-1605. https://doi.org/10.3390/biom11111605. Publicado • 10.3390/biom11111605 Benfeito, S.; Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, J.; Simões, R.; Cagide, F.; et al. "Mitochondria-targeted Caffeic Acid Derivative Reverts Cellular and Mitochondrial Defects in Human Skin Fibroblasts from Male Sporadic Parkinson’s Disease Patients". Redox Biology (2021): https://pubmed.ncbi.nlm.nih.gov/34147843/. Publicado • 10.1016/j.redox.2021.102037 Benfeito, Sofia; Chavarria, Daniel; Da Silva, Ophelie Da; Barreiro, Sandra; Garrido, Jorge; Cagide, Fernando; Soares, Pedro; et al. "Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases". Antioxidants 10 2 (2021): 329. http://dx.doi.org/10.3390/antiox10020329. Publicado • 10.3390/antiox10020329 Teixeira, José; Basit, Farhan; Willems, Peter H.G.M.; Wagenaars, Jori A.; van de Westerlo, Els; Amorim, Ricardo; Cagide, Fernando; et al. "Mitochondria-targeted phenolic antioxidants induce ROS-protective pathways in primary human skin fibroblasts". Free Radical Biology and Medicine 163 (2021): 314-324. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.023. Publicado • 10.1016/j.freeradbiomed.2020.12.023 Fernandes, Eduarda; Benfeito, Sofia; Cagide, Fernando; Gonçalves, Hugo; Bernstorff, Sigrid; Nieder, Jana B; CD Real Oliveira, M Elisabete; Borges, Fernanda; Lúcio, Marlene. "Lipid Nanosystems and Serum Protein as Biomimetic Interfaces: Predicting the Biodistribution of a Caffeic Acid-Based Antioxidant". Nanotechnology, Science and Applications Volume 14 (2021): 7-27. http://dx.doi.org/10.2147/nsa.s289355. Publicado • 10.2147/nsa.s289355 Benfeito, Sofia; Fernandes, Carlos; Vilar, Santiago; Remião, Fernando; Uriarte, Eugenio; Borges, Fernanda. Autor correspondente: Benfeito, Sofia. "Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer’s Disease Pathophysiological Hallmarks". Molecules 25 2 (2020): 276. http://dx.doi.org/10.3390/molecules25020276. Publicado • 10.3390/molecules25020276 Pinto, Miguel; Fernandes, Carlos; Martins, Eva; Silva, Renata; Benfeito, Sofia; Cagide, Fernando; Mendes, Ricardo F.; et al. "Boosting Drug Discovery for Parkinson’s: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles". Pharmaceutics 11 7 (2019): 331. http://dx.doi.org/10.3390/pharmaceutics11070331. Publicado • 10.3390/pharmaceutics11070331 Benfeito, S.; Oliveira, C.; Fernandes, C.; Cagide, F.; Teixeira, J.; Amorim, R.; Garrido, J.; et al. "Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction". European Journal of Medicinal Chemistry 167 (2019): 525-545. http://dx.doi.org/10.1016/j.ejmech.2019.01.055. Publicado • 10.1016/j.ejmech.2019.01.055 Fernandes, C.; Benfeito, S.; Amorim, R.; Teixeira, J.; Oliveira, P.J.; Remião, F.; Borges, F.. "Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy". Bioconjugate Chemistry 29 8 (2018): 2723-2733. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049630986&partnerID=MN8TOARS. Publicado • 10.1021/acs.bioconjchem.8b00383 Ribeiro, J.A.; Benfeito, S.; Cagide, F.; Teixeira, J.; Oliveira, P.J.; Borges, F.; Silva, A.F.; Pereira, C.M.. "Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity". Analytical Chemistry 90 13 (2018): 7989-7996. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048133687&partnerID=MN8TOARS. Publicado • 10.1021/acs.analchem.8b00787 Oliveira, C.; Benfeito, S.; Fernandes, C.; Cagide, F.; Silva, T.; Borges, F.. "NO and HNO donors, nitrones, and nitroxides: Past, present, and future". Medicinal Research Reviews 38 4 (2017): 1159-1187. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048825299&partnerID=MN8TOARS. Publicado • 10.1002/med.21461 Teixeira, J.; Cagide, F.; Benfeito, S.; Soares, P.; Garrido, J.; Baldeiras, I.; Ribeiro, J.A.; et al. "Development of a mitochondriotropic antioxidant based on caffeic acid: Proof of concept on cellular and mitochondrial oxidative stress models". Journal of Medicinal Chemistry 60 16 (2017): 7084-7098. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028330575&partnerID=MN8TOARS. Publicado • 10.1021/acs.jmedchem.7b00741 Benfeito, S.; Andrade, M.; Soares, P.; Magalhães e Silva, D.; Loureiro, J.; Borges, A.; Borges, F.; Simões, M.. "Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli". RSC Advances 5 66 (2015): 53915-53925. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934935449&partnerID=MN8TOARS. Publicado • 10.1039/c5ra05840f Teixeira, J.; Soares, P.; Benfeito, S.; Murphy, Michael P.; Oliveira, P.J.; Borges, F.. "Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria". Methods in Molecular Biology 1265 (2015): 1-10. https://pubmed.ncbi.nlm.nih.gov/25634268/. Publicado • 10.1007/978-1-4939-2288-8_6. Benfeito, S.; Silva, T.; Garrido, J.; Andrade, P.B.; Sottomayor, M.J.; Borges, F.; Garrido, E.M.. "Effects of chlorophenoxy herbicides and their main transformation products on dna damage and acetylcholinesterase activity". BioMed Research International 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899555466&partnerID=MN8TOARS. Publicado • 10.1155/2014/709036 Fernandes, C.; Oliveira, C.; Benfeito, S.; Soares, P.; Garrido, J.; Borges, F.. "Nanotechnology and antioxidant therapy: An emerging approach for neurodegenerative diseases". Current Medicinal Chemistry 21 38 (2014): 4311-4327. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929085543&partnerID=MN8TOARS. Publicado • 10.2174/0929867321666140915141836 Benfeito, S.; Rodrigues, T.; Garrido, J.; Borges, F.; Garrido, E.M.. "Host-Guest interaction between herbicide oxadiargyl and hydroxypropyl- ß -Cyclodextrin". The Scientific World Journal 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893859565&partnerID=MN8TOARS. Publicado • 10.1155/2013/825206 Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F.. "Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids". European Journal of Medicinal Chemistry 62 (2013): 289-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873030904&partnerID=MN8TOARS. Publicado • 10.1016/j.ejmech.2012.12.049 Benfeito, S.; Oliveira, C.; Soares, P.; Fernandes, C.; Silva, T.; Teixeira, J.; Borges, F.. "Antioxidant therapy: Still in search of the 'magic bullet'". Mitochondrion 13 5 (2012): 427-435. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882877558&partnerID=MN8TOARS. Publicado • 10.1016/j.mito.2012.12.002 Teixeira, J.; Soares, P.; Benfeito, S.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F.. "Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold". Free Radical Research 46 5 (2012): 600-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859067775&partnerID=MN8TOARS. Publicado • 10.3109/10715762.2012.662593
Capítulo de livro	Silva, C.; Pinto, M.; Fernandes, C.; Benfeito, S.; Borges, F.. "Antioxidant therapy and neurodegenerative disorders: lessons from clinical trials". In Systems Medicine: Integrative, Qualitative and Computational Approaches, editado por Olaf Wolkenhauer. Porto, Portugal: Elsevier, 2020. Publicado • 10.1016/B978-0-12-801238-3.11611-3 Pinto, M.; Benfeito, S.; Fernandes, C.; Borges, F.. "Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants". In Oxidative Stress and Dietary Antioxidants in Neurological Diseases, editado por Victor R. Preedy, 125-141. Porto, Portugal: Academic Press- Elsevier Science, 2019. Publicado • 10.1016/B978-0-12-817780-8.00009-8 Fernandes, Carlos; Benfeito, Sofia; Fonseca, André; Oliveira, Catarina; Garrido, Jorge; Garrido, E. Manuela; Borges, Fernanda. "Photodamage and photoprotection: toward safety and sustainability through nanotechnology solutions". In Food Preservation, editado por Alexandru Grumezescu, 527-565. Porto, Portugal: Elsevier, 2018. Publicado • 10.1016/b978-0-12-804303-5.00015-8 Amorim, Ricardo; Benfeito, Sofia; Teixeira, José; Cagide, Fernando; Oliveira, Paulo J.; Borges, Fernanda. "Targeting Mitochondria: The Road to Mitochondriotropic Antioxidants and Beyond". In Mitochondrial Biology and Experimental Therapeutics, editado por Oliveira, P.J., 333-358. Porto, Portugal: Springer International Publishing, 2018. Publicado • 10.1007/978-3-319-73344-9_16 Benfeito, S.; Silva, T.; Garrido, E.M.; Borges, F.; Garrido, J.. "Synthesis of lipophilic antioxidants based on natural models". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, editado por Carlos A. M. Afonso; Robert Franzén; Bin Tanc; Dulce Simão; Alexandre Trindade; Jaime Coelho; Nuno R. Candeias, 380-386. Porto, Portugal: Royal Chemical Society, 2016. Publicado • 978-1-84973-963-4 Teixeira, José; Soares, Pedro; Benfeito, Sofia; Murphy, Michael P.; Oliveira, Paulo J.; Borges, Fernanda. "Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria". In Methods in Molecular Biology, 73-83. Springer New York, 2015. Publicado • 10.1007/978-1-4939-2288-8_6 Benfeito, S.; Garrido, J.; Sottomayor, M.J.; Borges, F.; Manuela Garrido, E.. "Pesticides and cancer: Studies on the interaction of phenoxy acid herbicides with DNA". In handbook on herbicides: Biological Activity, Classification and Health & Environmental Implications, editado por Kobayashi, D.; Watanabe, E., 246-261. Porto, Portugal: Nova Science Publishers, Inc., 2014. Publicado • 978-1-62948-053-4
Poster em conferência	Soares, L.; Lima, C.; Chavarria, D.; Sequeira, L.; Alves, C.; Borges, F.; Benfeito, Ester. "Development of new iron chelators targeting mitochondia with potential application in Friedreich ataxia". Trabalho apresentado em IJUP - Investigação Jovem da Universidade do Porto (17th Edition), 2024. Castelôa, M.; Lima, C.; Benfeito, S.; Soares, P.; Borges, F.; Chavarria, D.. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Trabalho apresentado em XII Meeting of the Paul Ehrlich Euro-PhD Network, Thessaloniki, Greece, 2023. Magalhães, C.; Veloso, C.; Silveira, R. ; Djedovic, I.; Mendes, V.; Karkucinska-Wieckowska, A.; Amorim, R.; et al. "The mitochondriotropic antioxidant antioxcin4 prevents nafld/nash-induced cardiac alterations". Trabalho apresentado em 57th ESCI 2023 Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, Czech Republic,, 2023. Lima, C.; Borges, F.; Benfeito, S.. "Development of new multitarget-directed ligands with potential application in Alzheimer’s disease". Trabalho apresentado em MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Veloso, C.; Magalhães, C.; Silveira, R. ; Djedovic, I.; Mendes, V.; Karkucinska-Wieckowska, A.; Amorim, R.; et al. "Alterations in cardiac metabolism in Western Diet-induced metabolic syndrome: exploring the effects of AntiOxCIN4, a mitochondriotropic antioxidant.". Trabalho apresentado em MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Amorim, R.; Magalhães, C.; Benfeito, S.; Tavares, L.; Jones, J.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "ANTICANCER PROPERTIES OF ANTIOXCIN6, A NOVEL MITOCHONDRIA-TARGETED CAFFEIC ACID DERIVATIVE". Trabalho apresentado em MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Barreiro, Sandra; Benfeito, S.; Fernandes, C.; Chavarria, D.; Cagide, F.; Sequeira, L.; Teixeira, J.; et al. "Nitrogen-based cationic carriers as a game changer in the development of mitochondriotropic antioxidants". Trabalho apresentado em MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Alves, C.; Benfeito, S.; Cagide, F.; Borges, F.. "Development of new antimicrobial compounds to fight infectious diseases". Trabalho apresentado em IJUP'23 -XVI Encontro de Jovens Investigadores da Universidade do Porto , Porto, Portugal, 2023. Costa, I.; Benfeito, S.; Silva, V.; Cagide, F.; Borges, F.; Remião, F.; Silva, R.. "New mitochondria-targeted hydroxycinnamic and hydroxybenzoic acids derivatives as innovative agents for the treatment of Parkinson’s disease". Trabalho apresentado em IJUP'23 -XVI Encontro de Jovens Investigadores da Universidade do Porto , Porto, Portugal, 2023. Albuquerque, B.; Benfeito, S.; Chavarria, D.; Serrao, M.P.; Borges, F.; Soares-da-Silva, Patricio. "Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors". Trabalho apresentado em IJUP'23 - XVI Encontro de Jovens Investigadores da Universidade do Porto, Porto, Portugal, 2023. Costa, I.; Benfeito, S.; Silva, V.; Cagide, F.; Borges, F.; Remiao, F.; Silva, R.. "Mitochondria-targeted antioxidants as powerful therapeutic strategies for Parkinson’s disease: in vitro evaluation of neuroprotective effects". Trabalho apresentado em MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Costa, I.; Benfeito, S.; Silva, V.; Cagide, F.; Borges, F.; Remião, F.; Silva, R.. "In vitro evaluation of the neuroprotective effects of new mitochondria-targeted antioxidants with potential for Parkinson¿s disease treatment". Trabalho apresentado em II TOXRUN International Congress 2023, Porto, Portugal, 2023. Silva, V.; Benfeito, S.; Lima, C.; Chavarria, D.; Gonçalves, T.; Costa, I.; Remiao, F.; Borges, F.; Silva, R.. "3-hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson’s disease". Trabalho apresentado em II TOXRUN International Congress 2023, Porto, Portugal, 2023. Magalhães, C.; Veloso, C.; Silveira, R. ; Djedovic, I.; Mendes, V.; Karkucinska-Wieckowska, A.; Amorim, R.; et al. "Antioxidante mitocondriotrópico AntiOxCIN4 previne as alterações cardíacas no contexto da doença do fígado gordo não-alcóolico". Trabalho apresentado em 19º Congresso Português de Diabetes, Vilamoura, Portugal, 2023. Castelôa, M.; Soares, P.; Benfeito, Ester; Lima, C.; Borges, F.; Chavarria, D.. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, Spain, 2022. Benfeito, S.; Fernandes, C.; Chavarria, D.; Barreiro, S.; Cagide, F.; Silva, C.; Teixeira, J.; et al. "Synthesis and in vitro evaluation of versatile cell-penetrating mitochondriotropic antioxidants". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, Spain, 2022. Benfeito, S.; Lima, C.; Borges, F.. "Development of new multitarget-directed ligands with potential application in Alzheimer’s disease". Trabalho apresentado em 1º Encontro de Ciências, Porto, Portugal, 2022. Inês Costa; Vera Silva; Sofia Benfeito; Fernando Cagide; Fernanda Borges; Fernando Remião; Renata Silva. "New mitochondria-targeted antioxidants as promising drug candidates for the treatment of Parkinson's disease". Trabalho apresentado em XVIth International Congress of Toxicology (IUTOX), Maastricht, the Netherlands, 2022. Vera Silva; Sofia Benfeito; Inês Costa; Fernando Remião; Fernanda Borges. "Evaluation of cytotoxic and Neuroprotective profile of potential dual-acting ligands for the treatment of Parkinson’s disease". Trabalho apresentado em MedChem 2022 (XI Paul Ehrlich Euro-PhD Network meeting), Barcelona, Spain, 2022. Cátia Silva; Pedro Soares; Fernando Cagide; Sofia Benfeito; Fernando Remião; Sónia Rocha; P.J. Oliveira; Fernanda Borges. "Targeting Antioxidants to Mitochondria: a new therapeutic track for Amyotrophic Lateral Sclerosis". Trabalho apresentado em MedChem 2022 (XI Paul Ehrlich Euro-PhD Network meeting), Barcelona, Spain, 2022. Daniel Chavarria; Anabela Borges; Sofia Benfeito; Carlos Fernandes; Catarina Oliveira; Marta Ribeiro; Manuel Simões; Fernanda Borges; Fernando Cagide. "Quaternary phosphonium conjugates: a new class of antimicrobial agents?". Trabalho apresentado em MedChem 2022 (XI Paul Ehrlich Euro-PhD Network meeting), Barcelona, Spain, 2022. Daniel Chavarria; Sofia Benfeito; Jorge Garrido; Paula Serrão; Soares-da-Silva, Patricio; Fernado Remião; P.J. Oliveira; Fernanda Borges. "Tackling dopamine depletion and oxidative stress with innovative caffeic acid derivatives”". Trabalho apresentado em X Meeting of the Paul Ehrlich Euro-PhD Network, Barcelona, Spain, 2022. Francesca Procopio; Raffaella Catalano; Daniel Chavarria; Sofia Benfeito; Stefano Alcaro; Fernanda Borges; Francesco Ortuso. "Non-Chiral Components of Bergamot Essential Oil: Identification of a Novel, Selective Human Monoamine Oxidase B Inhibitor". Trabalho apresentado em MedChem 2022 (XI Paul Ehrlich Euro-PhD Network meeting), Barcelona, Spain, 2022. R. Amorim; I. Simões; J. Teixeira; P. Soares; S. Benfeito; Y. Potes; S. Pereira; Oliveira, P.J.; F. Borges. "Mitochondriotropic antioxidant AntiOxCin4 improves mitochondrial function and prevents non-alcoholic fatty liver (NAFL)-associated autophagic blockage in Western diet (WD)-fed mice". Trabalho apresentado em 56th Annual Scientific Meeting - European Society for Clinical Investigation (ESCI), Bari, Italy, 2022. D. Mena; P. Soares; F. Cagide; S. Benfeito; L. Grilo; P. Valente; Borges, F.; P.J.Oliveira. "The mitochondria-targeted antioxidant AntiOxCIN4 is beneficial against oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G3A Mouse". Trabalho apresentado em 56th Annual Scientific Meeting - European Society for Clinical Investigation (ESCI), Bari, Italy, 2022. Ines Costa; Vera Silva; Benfeito, Sofia; Fernando Remião; Fernanda Borges; Renata Silva. "New mitochondria-targeted antioxidants as potential neuroprotective agentes". Trabalho apresentado em Encontro de Jovens Investigadores da Universidade do Porto (IJUP), Porto, Portugal, 2022. Vera Silva; Benfeito, Sofia; Ines Costa; Eva Gil-Martins; Fernando Remião; Fernanda Borges; Renata Silva. "In vitro neuroprotective effects of dual-acting antiparkinsonians". Trabalho apresentado em TOXRUN - Unidade de Investigação em Toxicologia do Instituto Universitário de Ciências da Saúde - CESPU, Porto, Portugal, 2022. Vera Silva; Sofia Benfeito; Eva Gil-Martins; Inês Costa; Fernando Remião; Fernanda Borges; Renata Silva. "In vitro neuroprotective effects of dual-acting antiparkinsonians". Trabalho apresentado em RevSALUS- Revista Científica Internacional da refe académica das Ciências da Saúde da Lusofonia, Porto, Portugal, 2022. Mena, D.; Saores, P. ; Benfeito, S.; Cagide, F.; Grilo, L.; Valente, P.; Pinheiro, P.; et al. "Beneficial effects of the mitochondria-targeted antioxidant AntiOxCIN4 against oxidative/nitrosative stress in the Amyotrophic Lateral Sclerosis SOD1G93A mouse". Trabalho apresentado em BEB Day 2022-The Overview Effect, Coimbra, Portugal, 2022. Mena, D.; Soares, P.; Benfeito, S.; Grilo, L.; Silva, D.; Valente, P.; Pinheiro, P.; et al. "Protective effects of the mitochondria-targeted antioxidant Antioxcin4 against oxidative stress in the amyotrophic lateral sclerosis sod1g93a mouse". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (Virtual Meeting), 2021. Mena, D.; Soares, P.; Cagide, F.; Benfeito, S.; Grilo, L.; Valente, P.; Pinheiro, P.; et al. "The Mitochondria-Targeted Antioxidant AntiOxCIN4 Protects Against Oxidative/Nitrosative Stress in the Amyotrophic Lateral Sclerosis SOD1GG3A Mouse". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021. Amorim, R.; Benfeito, S.; Borges, F.; Oliveira, P.J.. "Mitochondria-targeted antioxidant based on caffeic acid AntiOxCIN4 prevented hepatic lipid accumulation by avoided Western Diet-induced autophagic blockage". Trabalho apresentado em EASL NAFLD Summit 2021 (Virtual Meeting), 2021. Catalao, R.; Maruca, A.; Rocca, S.; Borges, F.; Benfeito, S.; Chavarria, D.; Alcaro, S.; Ortuso, F.. "Phytocompounds and their metabolites profiling, as promising multi-target agents for the treatment of Alzheimer's disease". Trabalho apresentado em Virtual Meeting of the Paul Ehrlich Euro-PhD Network, 2021. Matins, J.; Duarte, J.; Veloso, C.; Fernandes, C.; Benfeito, S.; Santos, A.; Borges, F.; Oliveira, P.J.. "Mitochondriotropic antioxidants based on caffeic acid (MC4) protects H9c2 cardiomyoblasts against the cardiotoxicity of doxorubicin". Trabalho apresentado em Virtual Meeting of 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's - Exploring microbiota in health and disease, 2021. Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, J.; Cagide, F.; Benfeito, S.; Borges, F.; Oliveira, P.J.. "A novel phenolic acid-based mitochondria-targeted antioxidant improves cellular responses to oxidative stress in fibroblasts from sporadic Parkinson’s disease patients". Trabalho apresentado em Virtual Meeting of 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's - Exploring microbiota in health and disease, 2021. Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, J.; Simões, I.; Cagide, F.; Benfeito, S.; Borges, F.; Oliveira, P.J.. "AntiOxCIN4 a new mitochondriotropic derivative based on the natural polyphenol caffeic acid reverts cellular and mitochondrial metabolic defects of fibroblasts from idiopathic Parkinson’s disease". Trabalho apresentado em 55th Annual meeting of The European Society for Clinical Investigation, “The Micro Me’s – Exploring microbiota in health and disease (virtual meeting), 2021. Duarte, A.; Coelho, A.; Mena, D.; Silva, F.; Marques, R. ; Cagide, F.; Benfeito, S.; et al. "Effect of novel mitochondria-targeted antioxidants in human skin fibroblasts". Trabalho apresentado em 55th Annual meeting of the European Society for Clinical Investigation, “The Micro Me’s – Exploring microbiota in health and disease, Virtual meeting, 2021. Castelôa, M.; Moreira-Pinto, B.; Benfeito, S; Borges, F.; Fonseca, B.; Rebelo, I.. "Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines". Trabalho apresentado em IJUP 2021 – 14th Meeting of Young Researchers of University of Porto (virtual meeting), 2021. Castelôa, M.; Moreira-Pinto, B.; Benfeito, S.; Borges, F.; Fonseca, B.; Rebelo, I.. "In vitro study of the effects of a TPP-based mitocan and two derivatives in type I and type II endometrial cancer cell lines". Trabalho apresentado em Warm-Up Olimpíadas Universitárias da Bioquímica- edição especial Covid-19. Concurso online de posters, 2021. Soares, P.; Benfeito, S.; Silva, C.; Silva, F.; Batie, M.; Oliveira, C.; Cagide, F.; et al. "Mitochondriotropic antioxidants as novel therapeutics for Amyotrophic lateral sclerosis: development of multitarget agents to prevent stress induced motor neuron death (BEST POSTER)". Trabalho apresentado em MuTaLig COST ACTION CA1513, 4th WG meeting, Izmir, Turkey, 2020. Benfeito, S.; Fernandes, C.; Vilar, S.; Remião, F.; Uriarte, E.; Borges, F.. "Exploring the multi-target performance of mitochondriotropic antioxidants against the pivotal Alzheimer’s disease pathophysiological hallmarks". Trabalho apresentado em MuTaLig COST ACTION CA1513, 4th WG meeting. Izmir, Turkey., 2020. Pinto, M.; Fernandes, F.; Martins, E.; Silva, R.; Benfeito, S.; Cagide, F.; Borges, F.; Remião, F.. "Bioavailability improvement of a monoamine oxidase-B inhibitor using PEGylated PCL-based nanoparticles". Trabalho apresentado em 55th Congress of the European Societies of Toxicology, Toxicology- Science Providing Solutions, Helsinki, Finlandia., 2019. Cagide, F.; Benfeito, S.; Oliveira, C.; Fernandes, C.; Gaspar, A.; Borges, F.. "Development of new antibiotics based on natural scaffolds". Trabalho apresentado em IX Meeting of the Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting, Catanzaro, Italy, 2019. Barbosa, A.; Amorim, R.; Benfeito, S.; Taveres, L.C.; Jones, J.G.; Veloso, C.; Oliveira, C.; Borges, F.; Olivera, P.J.. "Redox signaling and metabolism modulation of human fibriblasts by mitochondria-targeted polyphenolic constructs". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease”, Coimbra, Portugal, 2019. Benfeito, S.; Amorim, R.; Teixeira, J.; Cagide, F.; Tavares, L.C.; Jones, J.G.; Oliveira, P.J.; Borges, F.. "Unraveling the mechanism throughout mitochondriotropic cinnamic acid antioxidants increase cellular stress response in HepG2 cells". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease”, Coimbra, Portugal., 2019. Deus, C.M.; Pereira, S.; Cunha-Oliveira, T.; Benfeito, S.; Cagide, F.; Borges, F.; Raimundo, N.; Oliveira, P.J.. "Human skin fibroblasts from sporadic Parkinson’s disease patients as a surrogate to measure the efficacy of a novel mitochondria-directed antioxidant therapy". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease”, Coimbra, Portugal, 2019. Benfeito, S.; Oliveira, C.; Fernandes, C.; Cagide, F.; Teixeira, J.; Amorim, R.; Garrido, J.; et al. "Design and synthesis of mitochondriotropic antioxidants based on dietary scaffold endowed with neuroprotective activity and BBB permeability". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease, Coimbra, Portugal., 2019. Veloso, C.; Benfeito, S.; Cagide, F.; Oliveira, C.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "Mitochondriotropic antioxidants based on dietary phenolic acids: Potential effect against chemical-induced skin senescence". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease”, Coimbra, Portugal,, 2019. Soares, P.; Benfeito, S.; Oliveira, C.; Cagide, F.; Fernandes, C.; Teixeira, J.; Amorim, R.; Oliveira, P.J; Borges, F.. "From nature inspiration to multitarget small molecules: upgrading the activity of dietary cinnamic and benzoic acids for the treatment of neurodegenerative disorders (BEST POSTER)". Trabalho apresentado em MuTaLig COST ACTION CA1513, 3th WG meeting, Paris, France., 2019. Barbosa, A.; Amorim, R.; Veloso, C.; Benfeito, S.; Oliveira, C.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "Targeting Phenolic Dietary Antioxidants to Mitochondria to Modulate Redox Signaling and Metabolism". Trabalho apresentado em Meeting Sociedade Portuguesa de Farmacologia (SPF), Universidade do Porto, Porto, Portugal, 2019. Veloso, C.; Cagide, F.; Benfeito, S.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "Mitochondriotropic antioxidants based on dietary hydroxycinnamic acids as an attempt to reduce skin aging". Trabalho apresentado em Meeting Sociedade Portuguesa de Farmacologia (SPF), Universidade do Porto, Porto, Portugal, 2019. Amorim, R.; Teixeira, J.; Veloso, C.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.. "Mitochondria-targeted Antioxidants in Human Hepatic Cells: A Conceivable Therapy for Non-Alcoholic Fatty Liver Disease". Trabalho apresentado em Targeting Mitochondria, Berlin, Germany., 2018. Cagide, F.; Benfeito, S.; Oliveira, C.; Fernandes, C.; Teixeira, J.; Amorim, R.; Garrido, J.; et al. "Fine-tuning the neuroprotective and blood-brain barrier permeability profile of dietary based mitochondria-targeted antioxidants". Trabalho apresentado em MuTaLig COST ACTION CA1513, WG meeting, Valletta, Malta, 2018. Fernandes, C.; Benfeito, S.; Amorim, R.; Teixeira, J.; Oliveira, P.J.; Remião, F.; Borges, F.. "Modulating the cytotoxicity of a mitochondriotropic antioxidant by a flexible PEGylation strategy". Trabalho apresentado em MuTaLig COST ACTION CA1513, WG meeting, Valletta, Malta, 2018. Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.. "Effects of mitochondria-targeted antioxidants in human hepatic cells: a possible therapy for hepatic steatosis". Trabalho apresentado em MuTaLig COST ACTION CA1513, WG meeting, Valletta, Malta, 2018. Teixeira, J.; Amorim, R.; Benfeito, S.; Cagide, F.; Oliveira, P.J.; Borges, F.. "Mitochondriotropic cinnamic acid antioxidants improves steatosis in a Non-Alcoholic Fatty Liver Disease (NAFLD) cell model". Trabalho apresentado em MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal, 2018. Amorim, R.; Teixeira, J.; Baldeiras, I.; Benfeito, S.; Cagide, F.; Garrido, J.; Oliveira, P.J.; Borges, F.. "Mitochondriotropic cinnamic acid antioxdiants increase celular stress responses in HepG2 cells: Involvement of (mt)ROS signaling?". Trabalho apresentado em MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal,, 2018. Deus, C.M.; Pereira, S.P.; Cunha-Oliveira, T.; Benfeito, S.; Cagide, F.; Borges, F.; Raimundo, N.; Oliveira, P.J.. "Targeting mitochondria with mitochondria-targeted cinnamic antioxdidants: a new avenue for sporadic Parkinson’s Disease therapy". Trabalho apresentado em MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal,, 2018. Veloso, C.; Cagide, F.; Benfeito, S.; Oliveira, C.; Borges, F.; Oliveira, P.J; Teixeira, J.. "Skin aging and mitochondriotropic antioxidants based on dietary hydroxycinnamic acids". Trabalho apresentado em MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal, 2018. Carreira, R.; Amorim, R.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "Effect of multi-functional mitochondria-targeted antioxidants in human skin fibroblasts". Trabalho apresentado em MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal, 2018. Benfeito, S.; Cagide, F.; Teixeira, J.; Amorim, R.; Remião, F.; Uriarte, E.; Oliveira, P.J.; Borges, F.. "Restoring acetylcholine levels and shielding mitochondria as a multi-target strategy for neurodegenerative diseases". Trabalho apresentado em VIII Meeting of the Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, 2018. Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Oliveira, P.J.; Borges, F.. "Mitochondriotropic cinnamic acid antioxidants increase cellular stress response in HepG2 cells: involvement of mitochondrial ROS signaling in a possible therapy for hepatic steatosis". Trabalho apresentado em 52nd Annual Meeting of the European Society for Clinical Investigation “Precision Medicine for Healthy Ageing”, Barcelona, Spain, 2018. Veloso, C.; Teixeira, J.; Cagide, F.; Benfeito, S.; Oliveira, C.; Borges, F.; Oliveira, P.J.. "Mitochondriotropic antioxidants based on dietary phenolic acids as modulators of oxidative stress on skin fibroblasts". Trabalho apresentado em 52nd Annual Meeting of the European Society for Clinical Investigation “Precision Medicine for Healthy Ageing”, Barcelona, Spain, 2018. Teixeira, J.; Amorim, R.; Carreira, R.; Cagide, F.; Benfeito, S.; Borges, F.; Oliveira, P.J.. "Effects of multi-operational mitochondria-targeted antioxidants in human hepatic cells: promising drugs for liver disease". Trabalho apresentado em 52nd Annual Meeting of the European Society for Clinical Investigation “Precision Medicine for Healthy Ageing”, Barcelona, Spain, 2018. Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Benfeito, S.; Cagide, F.; Borges, F.; Raimundo, N.; Oliveira, P. J.. "Targeting dietary antioxidants to mitochondria ameliorate metabolic alterations of skin fibroblasts from patients with sporadic Parkinson’s Disease". Trabalho apresentado em 52nd Annual Meeting of the European Society for Clinical Investigation “Precision Medicine for Healthy Ageing, Barcelona, Spain, 2018. Cagide, F.; Benfeito, S.; Teixeira, J.; Silva, R.; Remião, F.; Garrido, J.; Oliveira, P.J.; Uriarte, E.; Borges, F.. "Cationic derivatives of natural products as inhibitors of enzymes involved in Alzheimer's disease". Trabalho apresentado em MuTaLig COST ACTION CA1513, WG meeting, Tenerife, Spain, 2018. Teixeira, J.; Amorim, R.; Carreira, R.; Benfeito, S.; Cagide, F.; Oliveira, P.J.; Borges, F.. "Mitochondria-targeted cinnamic antioxidants increase celular stress response through modulation of mitochondria function/activity". Trabalho apresentado em MuTaLig COST action, Universidad de la Laguna, Tenerife, Spain, 2018. Benfeito, S.; Cagide, F.; Teixeira, J.; Amorim, R.; Remião, F.; Uriarte, E.; Oliveira, P.J.; Borges, F.. "Targeted delivery of mitocondriotropics derivatives: a new therapeutic approach for oxidative stress related diseases". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig COST (CA15135) Actions Joint Meeting, Porto, Portugal, 2017. Cagide, F.; Benfeito, S.; Fernandes, C.; Remião, F.; Uriarte, E.; Borges, F.. "Cationic derivatives based on cinnamic acid as dual-target ligands for the treatment of neurodegenerative diseases". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig COST (CA15135) Actions Joint Meeting, Porto, Portugal, 2017. Deus, C.M.; Pereira, S.P.; Cunha-Oliveira, T.; Benfeito, S.; Cagide, F.; Borges, F.; Raimundo, N.; Oliveira, P.J.. "Mitochondria-directed antioxidants increased metabolic viability of human skin fibroblasts from Parkinson´s Disease patients". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig COST (CA15135) Actions Joint Meeting, Porto, Portugal, 2017. Cagide, F.; Benfeito, S.; Fernandes, C.; Remião, F.; Uriarte, E.; Borges, F.. "New bifunctional agents for the treatment of the oxidative stress associated with aging related diseases". Trabalho apresentado em VII Meeting of the Paul Ehrlich MedChem EuroPhD Network, Vienna, Austria, 2017. Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Garrido, J.; Oliveira, P.J.; Borges, F.. "Effects of different targeting cations on the toxicity profile of mitochondriotropic-hydroxycinnamic antioxidants". Trabalho apresentado em MitoPorto: Advances in Mitochondrial Research International Symposium, Porto, Portugal, 2017. Benfeito, S.; Remião, F.; Uriarte, E.; Borges, F.. "Development of bifunctional agents for ameliorating the oxidative stress associated with aging related diseases". Trabalho apresentado em Mutalig COST Action, 1st WG meeting “Poly-pharmacology expanding Paul Elrlich’s magic bullet concept”, Budapest, Hungry, 2016. Benfeito, S.; Remião, F.; Uriarte, E.; Borges, F.. "Development of bifunctional agents for ameliorating the oxidative stress associated with aging related diseases (BEST POSTER)". Trabalho apresentado em 36th Edition of the European School of Medicinal Chemistry (ESMEC), Urbino, Italy, 2016. Benfeito, S.; Andrade, M.; Soares, P.; Simões, M.; Borges, F.. "Fine-tuning of the antimicrobial activity of caffeic acid". Trabalho apresentado em XXII Young Research Fellow Meeting, Paris, France, 2015. Benfeito, S.; Silva, T.; Garrido, J.; Remiao, F.; Borges, F.. "Development of novel cinnamoyl-piperazine derivatives endowed with antioxidant-anticholinesterase activity". Trabalho apresentado em Paul Ehrlich MedChem - Euro PhD Network, Prague, Czech Republic, 2014. Teixeira, J.; Cagide, F.; Benfeito, S.; Soares, P.; Borges, F.; Oliveira, P.J.; Murphy, M.P.; Andrade, P.B.. "MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria". Trabalho apresentado em 8th World Congress on Polyphenols Applications: ISANH Polyphenols, Lisboa, Portugal, 2014. Cerqueira, A.; Benfeito, S.; Garrido, J.; Borges, F.; Garrido, E.M.. "Cyclodextrin-encapsulated herbicides: A promising technology". Trabalho apresentado em IJUP14 7th Meeting of the young researchers of U. Porto, Porto, Portugal, 2014. Benfeito, S.; Garrido, J.; Sottomayor, M.J.; Borges, F.; Garrido, E.M.. "Avaliação da interacção entre os herbicidas fenoxiacéticos e o ADN". Trabalho apresentado em XIX Encontro Luso-Galego de Química, Spain, Vigo, 2013. Garrido, E.M.; Benfeito, S.; Fernandes, C.; Garrido, J.; Blorges, F.. "Cyclodextrins: an eco-friendly contribution to management of herbicide MCPA". Trabalho apresentado em 10th Green Chemistry Conference, Spain, Barcelona,, 2013. Oliveira, C.; Benfeito, S.; Teixeira, J.; Amorim, R.; Gaspar, A.; Garrido, J.; Uriarte, E; Oliveira, P.J.; Borges, F.. "Remaking of Dietary Antioxidants: Targeting MitoBEN’s to Mitochondria as a New Therapeutic Strategy". Trabalho apresentado em 10º Encontro Nacional de Química Orgânica- 10ENQO, Lisboa, Portugal, 2013. Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Uriarte, E.; Oliveira, P.J.; Borges, F.. "Targeted Delivery of MitoCIN's: a new Therapeutic Approach for Oxidative Stress Related Diseases". Trabalho apresentado em 10º Encontro Nacional de Química Orgânica- 10ENQO, Portugal, Lisbon, 2013. Benfeito, S.; Garrido, J.; Garrido, E. M.; Sottomayor, M.J.; Borges, F.. "Study of the interaction of Phenoxyacetic acid herbicides with DNA using UV-Vis Spectroscopy". Trabalho apresentado em 11º Encontro Nacional de Química Física- 11ENQF, Porto, Portugal, 2013. Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, E. M.; Garrido, J.; Borges, F.. "Exploring natural profits: development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Trabalho apresentado em 16th biennial meeting for the Society for Free Radical Research International, London, UK, 2012. Oliveira, C.; Benfeito, S.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Bridging the gap between Nature and antioxidant setbacks: delivering hydroxybenzoic acids to mitochondria". Trabalho apresentado em 16th biennial meeting for the Society for Free Radical Research International, London, UK, 2012. Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Opening a new avenue in neurodegenerative therapy: lead optimization of a mitochondria-targeted cinnamic antioxidant". Trabalho apresentado em 16th biennial meeting for the Society for Free Radical Research International, London, UK, 2012. Borges, F.; Gaspar, A.; Silva, T.; Teixeira, J.; Cagide, F.; Benfeito, S.; Oliveira, C.; et al. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Trabalho apresentado em 22nd International Symposium on Medicinal Chemistry, Berlin, Germany, 2012. Oliveira, C.; Benfeito, S.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Opening a new avenue in neurodegenerative therapy: development of a mitochondria-targeted antioxidants based on benzoic scaffold". Trabalho apresentado em IJUP12 5th Meeting of the young researchers of U. Porto, Porto, Portugal, 2012. Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Opening a new avenue in neurodegenerative therapy: lead optimization of a mitochondria-targeted cinnamic antioxidant". Trabalho apresentado em IJUP12 5th Meeting of the young researchers of U. Porto, abstract book, Porto, Portugal, 2012. Teixeira, J.; Soares, P.; Benfeito, S.; Oliveira, C.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F.. "Mitochondria-targeted cinnamic antioxidants: Novel Promising Drugs for treatment of Alzheimer disease". Trabalho apresentado em 6th Drug discovery for neurodegeneration conference: an intensive course on translating research into drugs, New York, USA, 2012. Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Targeting phenolic antioxidants to mitochondria: synthesis and characterization of novel triphenylphosphonium- conjugated lipophilic cinnamic derivatives". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry in Faculty of Sciences of the University of Porto, Porto, Portugal, 2011. Teixeira, J.; Benfeito, S.; Soares, P.; Borges, F.; Gaspar, A.; Garrido, J.. "Lipophilic cinnamic cations: new mitochondria-targeted antioxidants for neurodegenerative disease therapy". Trabalho apresentado em IJUP11 4th Meeting of the young researchers of U. Porto, Porto, Portugal, 2011. Benfeito, S.; Couto, M.. "Anticancer agents derived from natural products”, first workshop in Medicinal Chemistry: Drug Discovery and Development: Understanding the R&D Process,". Trabalho apresentado em Faculty of Sciences of the University of Porto, Porto, Portugal, 2010.
Pré-impressão	Sequeira, L.; Benfeito, S.; Fernandes, C.; Gaspar, A.; Lima, I.; Peixoto, C.; Alves, C.; et al. "Drug development for Alzheimer’s and Parkinson’s disease: where do we go now?". 2024. https://www.preprints.org/manuscript/202404.0437/v1.
Resumo em conferência	Mena, D.; Cagide, F.; Benfeito, S.; Soares, P.; Grilo, L.; Pinheiro, P.; Teixeira, J.; et al. "The mitochondria-targeted antioxidant AntiOxCIN4 protects against cardiac oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G93A mouse". Trabalho apresentado em 57th ESCI 2023 Annual Scientific Meeting of the European Society for Clinical Investigation, Praga, 2023. Aceite para publicação I. Costa; Benfeito, S.; V. Silva; F. Cagide; F. Borges; F. Remião; R. Silva. "Neuroprotective effects of mitochondria-targeted antioxidants in a Parkinson’s disease in vitro model". Trabalho apresentado em II TOXRUN International Congress 2023, Porto, 2023. Publicado • 2795-5117 Silva, V.; Benfeito, S.; Lima, C.; Chavarria, D.; Gonçalves, T.; Costa, I.; Remião, F.; Borges, F.; Silva, R.. "3-hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson¿s disease". Trabalho apresentado em Revista Científica Internacional RevSALUS, Porto, 2023. Aceite para publicação Magalhães, C.; Veloso, C.; Karkucinska-Wieckowska, A.; Amorim, R.; Simões, I.; Benfeito, S.; Borges, F.; et al. "The mitochondriotropic antioxidant antioxcin4 prevents nafld/nash-induced cardiac alterations". Trabalho apresentado em 57th ESCI 2023 Annual Scientific Meeting of the European Society for Clinical Investigation, Praga, 2023. Aceite para publicação Benfeito, S.; Fernandes, C.; Chavarria, D.; Cagide, F.; Teixeira, J.; Oliveira, P.J.; Borges, F.; Uriarte, E.. "Synthesis and in vitro evaluation of versatile cell-penetrating mitochondriotropic antioxidants". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Publicado • 978-84-09-45895-0 Lima, C.; Borges, F.; Benfeito, S.. "Development of new multitarget-directed ligands with potential application in Alzheimer’s disease". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Publicado • 978-84-09-45895-0 Mariana Castelôa; Pedro Soares; Benfeito, S.; Carla Lima; Fernanda Borges; Daniel Chavarria. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Publicado • 978-84-09-45895-0 J. Teixeira; R. Amorim; I. Simões; F. Cagide; P. Soares; Benfeito, S.; M. Wieckowski; F. Borges; P.J. Oliveira. "Mitochondriotropic Antioxidants Based on Hydroxycinnamic Acids Activates Nrf2 Mediated Cell Signalling responses to Oxidative Stress: Implications in Non-Alcoholic Fatty Liver Disease (NAFLD)". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022. Publicado • 10.1111/eci.13796 P. Soares; A. Alefim; D. Mena; C. Fernandes; S. Benfeito; P.J. Oliveira; F. Borges. "Targeting neuroinflammation and modulating iron dysregulation with innovative multitarget therapeutics for amyotrophic lateral sclerosis". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022. Publicado • 10.1111/eci.13796 R. Amorim; R. Simões; J. Teixeira; Benfeito, S.; S. Pereira; Y. Potes; P.J. Oliveira; F. Borges. "Mitochondriotropic antioxidant AntiOxCin4 improves mitochondrial function and prevents non-alcoholic fatty liver (NAFL)-associated autophagic blockage in Western diet (WD)-fed mice". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022. Publicado • 10.1111/eci.13796 D. Mena; P. Soares; S. Benfeito; F. Cagide; P. Valente; E. Ferreiro; P.J. Oliveira; F. Borges. "The mitochondria-targeted antioxidant AntiOxCIN4 is beneficial against oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G3A Mouse". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022. Publicado • 10.1111/eci.13796 V. Silva; S. Benfeito; E. Gil-Martins; I. Costa; F. Remião; F. Borges; R. Silva. "In vitro neuroprotective effects of dual-acting antiparkinsonians". Trabalho apresentado em Revista Científica Internacional RevSALUS, Porto, 2022. Publicado • 10.51126/revsalus.v4iSup.396 Costa, I.; Benfeito, S.; Cagide, F.; Silva, V.; Borges, F.; Remião, F.; Silva, R.. "New mitochondria-targeted antioxidants as promising drug candidates for the treatment of Parkinson’s disease". Trabalho apresentado em Toxicol. Lett, Maastricht, 2022. Publicado • 10.1016/j.toxlet.2022.07.803 Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.. "Decrypting the Nrf2-dependent antioxidant mechanism of action behind the beneficial effcts of the mitochondriotropic cinnamic acid AntiOxCIN4". Trabalho apresentado em 55th Annual meeting of the European Society for Clinical Investigation, “The Micro Me’s – Exploring microbiota in health and disease”, online, 2021. Publicado • 10.1111/eci.13567 Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, J.; Simões, R.; Cagide, F.; Benfeito, S.; Borges, F.. "A novel phenolic acid-based mitochondria-targeted antioxidant improves cellular responses to oxidative stress in fibroblasts from sporadic Parkinson's disease patients". Trabalho apresentado em 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me- Exploring microbiota in health and disease, Online, 2021. Publicado • 10.1111/eci.13567 Martins, J.; Duarte, J.; Veloso, C.; Fernande, C.; Videira, A.; Benfeito, S.; Santos, A.; et al. "Mitochondriotropic Antioxidant Based on Caffeic Acid (MC4) Protects H9c2 Cardiomyoblasts against the Cardiotoxicity of Doxorubicin". Trabalho apresentado em 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's -Exploring microbiota in health and disease, Online, 2021. Publicado • 10.1111/eci.13567 Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, T.; Simões, R.; Cagide, F.; Benfeito, S.; et al. "AntiOxCIN4 a new mitochondriotropic derivative based on the natural polyphenol caffeic acid reverts cellular and mitochondrial metabolic defects of fibroblasts from idiopathic Parkinson's Disease". Trabalho apresentado em 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's -Exploring microbiota in health and disease, Online, 2021. Publicado • 10.1111/eci.13567 Duarte, A.; Coelho, A.; Mena, D.; Silva,F.; Marques, R. ; Cagide, F.; Benfeito, S.; Soares, P.; Borges, F.. "Effect of Novel Mitochondria-Targeted Antioxidants in Human Skin Fibroblasts". Trabalho apresentado em 55th Annual meeting of the European Society for Clinical Investigation, The Micro Mes - Exploring microbiota in health and disease, Online, 2021. Publicado • 10.1111/eci.13567 Fernades, C.; Pinto, M.; Martins, E.; Silva, R.; Benfeito, S.; Mendes, R.; Paz, F.; Remião, F.; Borges, F.. "The nanomaterial toolkit for neurological disorders treatment.". Trabalho apresentado em Paper presented in CIQUP II Workshop Meeting, Porto, 2020. Publicado Deus, C; Pereira, SP; Cunha Oliveira, T; Benfeito, S; Cagide, F; Borges, F; Raimundo, N; Oliveira, PJ. "Human skin fibroblasts from sporadic Parkinson's disease patients as a surrogate to measure the efficacy of novel mitochondria-directed antioxidant therapy". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease”, Eur. J. Clin. Invest., Coimbra, 2019. Publicado • 10.1111/eci.13109 Veloso, C; Cagide, F; Benfeito, S; Oliveira, C; Borges, F; Oliveira, P; Teixeira, J. "Mitochondriotropic antioxidants based on dietary phenolic acids: Potential effect against chemical-induced skin senescence". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease”, Eur. J. Clin. Invest., Coimbra, 2019. Publicado • 10.1111/eci.13109 Pinto, M; Fernandes, C; Gil Martins, E; Silva, R; Benfeito, S; Cagide, F; Borges, F; Remiao, F. "Bioavailability improvement of a monoamine oxidase-B inhibitor using PEGylated PCL-based nanoparticles". Trabalho apresentado em 55th Congress of the European Societies of Toxicology, Toxicology- Science Providing Solutions, Helsinki, 2019. Publicado • 10.1016/j.toxlet.2019.09.002 Benfeito, S; Oliveira, C; Fernandes, C; Cagide, F; Teixeira, J; Amorim, R; Garrido, J; et al. "Design and synthesis of mitochondriotropic antioxidants based on dietary scaffolds endowed with neuroprotective activity and BBB permeability". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation- The Clocks of Metabolism and Disease¿, Eur. J. Clin. Invest., Coimbra, 2019. Publicado • 10.1111/eci.13109 Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Taveres, L.C.; Jones, J.G.; Borges, F.; Oliveira, P.J. "Unraveling the mechanism throughout mitochondriotropic cinnamic acid antioxidants increase cellular stress responses in HepG2 cells". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease”, Eur. J. Clin. Invest., Coimbra, 2019. Publicado • 10.1111/eci.13109 Barbosa, A.; Amorim, R.; Tavares, L.C.; Jones, J.G; Veloso, C.; Benfeito, S.; Oliveira, C.; et al. "Redox signaling and metabolism modulation of human fibroblasts by mitochondria-targeted polyphenolic constructs". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease”, Eur. J. Clin. Invest., Coimbra, 2019. Publicado • 10.1111/eci.13109 Deus, CM; Pereira, SP; Cunha Oliveira, T; Benfeito, S; Cagide, F; Borges, F; Raimundo, N; Oliveira, PJ. "Targeting dietary antioxidants to mitochondria ameliorate metabolic alterations of skin fibroblasts from patients with sporadic Parkinson's Disease". Trabalho apresentado em 52nd Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, Eur. J. Clin. Invest., Coimbra, 2018. Publicado • 10.1111/eci.12926 Veloso, C; Teixeira, J; Cagide, F; Benfeito, S; Oliveira, C; Borges, F; Oliveira, P. "Mitochondriotropic antioxidants based on dietary phenolic acids as modulators of oxidative stress on skin fibroblasts". Trabalho apresentado em 52nd Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, Eur. J. Clin. Invest., Barcelona, 2018. Publicado • 10.1111/eci.12926 Teixeira, J.; Amorim, R.; Carreira, R.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.. "Effects of multi-operational mitochondria-targeted antioxidants in human hepatic cells: promising drugs for liver disease.". Trabalho apresentado em 52nd Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, Eur. J. Clin. Invest., Barcelona, 2018. Publicado • 10.1111/eci.12926 Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Garrido, J.; Oliveira, P.J.; Borges, F.. "Mitochondriotropic cinnamic acid antioxidants increase cellular stress responses in HepG2 cells: involvement of mitochondrial ROS signaling in a possible therapy for hepatic steatosis?". Trabalho apresentado em 52nd Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, Eur. J. Clin. Invest., Barcelona, 2018. Publicado • 10.1111/eci.12926 Teixeira, J.; Basit, F.; Oliveira, P.J.; Willems, P.H.G.M.; Joosten-Wagenaars, J.; Cagide, F.; Benfeito, S.; Borges, F.; Koopman, W.J.H.. "Mitohormesis: An attempt by targeting hydroxycinnamic acid derivatives to mitochondria". Trabalho apresentado em 50th Annual Scientific Meeting of the European Society for Clinical Investigation, Eur. J. Clin. Invest.,, Paris, 2016. Publicado • 10.1111/eci.12613 Teixeira, J.; Benfeito, S.; Soares, P.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Oliveira, P.J.; Borges, F.. "Development of novel systems to deliver natural antioxidants to mitochondria: MitoCIN'S as a case study". Trabalho apresentado em 47th Annual Scientific Meeting of the European Society for Clinical Investigation, Eur. J. Clin. Invest., Albufeira, 2013. Publicado • 10.1111/eci.12059 Borges, F.; Gaspar, A.; Silva, T.; Teixeira, J.; Cagide, F.; Benfeito, S.; Oliveira, C.; et al. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Trabalho apresentado em EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. ChemMedChem, Berlim, 2012. Publicado Oliveira, C; Benfeito, S; Teixeira, J; Soares, P; Garrido, J; Borges, F. "Bridging the gap between nature and antioxidant setbacks: Delivering hydroxybenzoic acids to mitochondria". Trabalho apresentado em Society for Free Radical Research International 16th Biennial Meeting. Free Rad. Biol. Med., Londres, 2012. Publicado • 10.1016/j.freeradbiomed.2012.08.214 Teixeira, J; Silva, T; Benfeito, S; Gaspar, A; Garrido, J; Borges, F. "Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Trabalho apresentado em Society for Free Radical Research International 16th Biennial Meeting. Free Rad. Biol. Med., Londres, 2012. Publicado • 10.1016/j.freeradbiomed.2012.08.213 Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Opening a new avenue in neurodegenerative therapy: lead optimization of a mitochondria-targeted cinnamic antioxidant". Trabalho apresentado em Society for Free Radical Research International 16th Biennial Meeting. Free Rad. Biol. Med., Londres, 2012. Publicado • 10.1016/j.freeradbiomed.2012.08.214
Tese / Dissertação	Faculdade de Farmácia. "Design and development of multi-target agents for neurodegenerative diseases". Doutoramento, Universidade do Porto Faculdade de Farmácia, 2018. http://hdl.handle.net/10216/114025. Faculdade de Ciências. "Desenvolvimento de novos antioxidantes lipofílicos baseados no ácido cinâmico". Mestrado, Universidade do Porto Faculdade de Ciências, 2012. http://hdl.handle.net/10216/101959. Benfeito, S.. "Controlo de qualidade do vinho do Porto e estudo da evolução dos teores de potássio, cálcio e cobre ao longo do processo de envelhecimento/finalização por espectroscopia de absorção atómica". Licenciatura, Universidade do Porto Faculdade de Ciências, 2010.

Propriedade Intelectual

Patente	Fernanda Borges; Paulo Oliveira; José Teixeira; Fernando Cagide; Benfeito, S.. 2019. "HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF". Estados Unidos. Permitida Borges, F.; Oliveira, P.J.; Benfeito, S.; Teixeira, J.; Cagide, F.. 2018. "HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF". Portugal. Permitida
Pedido provisório de patente	2024. "Novel catechol-O-methyltransferase inhibitors, methods for preparation and use thereof". Protegido

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/11/22	Desenvolvimento de novos agentes antibacterianos para combater infeções hospitalares	XIX Encontro Luso-Galego de Química, Spain, Vigo (Porto, Portugal)
2023/06/07	The mitochondria-targeted antioxidant AntiOxCIN4 protects against cardiac oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G93A mouse	57th ESCI 2023 Annual Scientific Meeting of the European Society for Clinical Investigation Facuty of Sciences of University of Porto (Prague, República Checa)
2022/11/16	Development of new multitarget-directed ligands with potential application in Alzheimer's disease	Encontro Galego-Portugués de Química Faculty of Sciences of University of Porto (Santiago de Compostela, Espanha)
2022/06/08	Targeting neuroinflammation and modulating iron dysregulation with innovative multitarget therapeutics for Amyotrophic Lateral Sclerosis	56th Annual Scientific meeting – Promoting Biomedical Research, Equal Health, and Environment in the post-COVID Syndemic Era Faculty of Sciences of University of Porto (Bari, Itália)
2022/06/08	Mitochondriotropic Antioxidants Based on Hydroxycinnamic Acids Activates Nrf2-Mediated Cell Signalling Responses to Oxidative Stress: Implications in Non¬Alcoholic Fatty Liver Disease (NAFLD)	56th Annual Scientific meeting – Promoting Biomedical Research, Equal Health, and Environment in the post-COVID Syndemic Era Faculty of Sciences of University of Porto (Bari, Itália)
2022/05/04	Development of new multitarget-directed ligands with potential application in Alzheimer’s disease	IJUP'22 - 15th Meeting of the young researchers of the University of Porto Faculty of Sciences of University of Porto (Porto, Portugal)
2022/04/27	Development of new multitarget-directed ligands with potential application in Alzheimer’s disease	XIV Scientific Seminar- 2nd cycle studies in chemistry Faculty of Sciences of the University of Porto (Porto, Portugal)
2021/12/09	Protective effects of the mitochondria-targeted antioxidant ANTIOXCIN4 against oxidative stress in the amyotrophic lateral sclerosis sod1g93a mouse	2nd International Conference on Neuroprotection by Drugs, Nutraceuticals, and Physical Activity (virtual meeting) Center for Neuroscience and Cell Biology (online)
2021/12/01	The Mitochondria-Targeted Antioxidant AntiOxCIN4 Protects Against Oxidative/Nitrosative Stress in the Amyotrophic Lateral Sclerosis SOD1GG3A Mouse	XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal Centre for Neuroscience and Cell Biology (virtual meeting)
2021/12/01	Decrypting the Nfr2-dependent antioxidant protects against oxidative/nitrosative stress in the amyotrophic lateral sclerosis sod1g93a mouse	VII Meeting of the Portuguese Society for Neuroscience Centre for Neuroscience and Cell Biology (Coimbra, Portugal)
2021/10/14	Reverting cellular and mitochondrial defects in fibroblasts from sporadic Parkinson’s disease patients by using a new mitochondria-targeted antioxidant	International conference on Oxidative Stress, Redox Homeostasis and Antioxidants 2021 Centre for Neuroscience and Cell Biology (virtual meeting)
2021/10/07	Tackling antimicrobial resistance with novel phytochemical-based conjugates: a structure-activity-toxicity study	E-Conference on Innovation in Microbial Control Faculty of Engeneering of the University of Porto (virtual meeting)
2021/07/26	Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders.	Paul Ehrlich Virtual Meeting 2021 Faculty of Sciences of the University of Porto (virtual meeting)
2021/06/09	Decrypting the Nrf2-dependent antioxidant mechanism of action behind the beneficial effcts of the mitochondriotropic cinnamic acid AntiOxCIN4	55th Annual meeting of he European Society for Clinical Investigation, “The Micro Me’s – Exploring microbiota in health and disease Centre for Neuroscience and Cell Biology (virtual meeting)
2021/06/09	Effect of novel mitochondria-targeted antioxidants in human skin fibroblasts	55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's -Exploring microbiota in health and disease¿ Centre for Neuroscience and Cell Biology (virtual meeting)
2021/05/05	Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines	Encontro de Jovens Investigadores da Universidade do Porto (IJUP) Faculty of Sciences of the University of Porto (virtual meeting)
2021/04/23	The effects of a TPP-based compound and two derivatives in ovarian and endometrial cancer cells	Biotechnology and Synthetic Biology (BioSynBio) Faculty of Sciences of the University of Porto (virtual meeting)
2020/03/05	Mitochondriotropic Cinnamic Acid Antioxidant Improves Cellular Resistance to Stress (BEST ORAL COMMUNICATION)	MuTaLig COST ACTION CA1513, 4th WG meeting (Izmir, Turquia)
2020/02/22	The nanomaterial toolkit for neurological disorders treatment	II Workshop meeting CIQUP Faculty of Sciences of the University of Porto (Porto, Portugal)
2019/10/28	Antioxidant, hormetic-like properties of AntiOXCIN4, a novel hydroxycinnamic acid-based mitochondria-targeted agent	10th World Congress on Targeting Mitochondria (Berlim, Alemanha)
2019/06/13	Design and development of multi-target agents for neurodegenerative diseases	Paul Ehrlich Euro-PhD Network & MuTaLig COST Action (Catanzaro, Itália)
2019/06/13	PEGylation technology – the second chance for non-bioavailable drug candidates	IX Meeting of the Paul Ehrlich Euro-PhD Network & 4th Annual meeting – MuTaLig COST Action (Catanzaro, Itália)
2019/02/20	Improving the activity of dietary cinnamic and benzoic acids for the treatment of neurodegenerative disorders	26th Young Research Fellows meeting (Paris, França)
2019/02/08	Targeting Phenolic Dietary Antioxidants to Mitochondria to Modulate Redox Signaling and Metabolism	Portuguese Society of Pharmacology (Porto, Portugal)
2019/02/06	Mitochondriotropic antioxidants based on dietary hydroxycinnamic acids as an attempt to reduce skin aging	Portuguese Society of Pharmacology (Porto, Portugal)
2018/10/23	Mitochondria-targeted antioxidants in human hepatic cells: a conceivable therapy for non-alcoholic fatty liver disease	9th World Congress on Targeting Mitochondria (Berlim, Alemanha)
2018/10/18	History in the Making: development of multi-target-directed ligands for Alzheimer's disease that modulate oxidative stress/mitochondria quality and the cholinergic system	MuTaLig COST ACTION CA1513, WG meeting (Valletta, Malta)
2018/03/15	Mitochondriotropic antioxidants based on cinnamic acid derivatives increase celular stress responses in HepG2 cells	MuTaLig COST action (Tenerife, Espanha)
2018/02/25	Skin mitohormesis by targeting hydroxycinnamic acid derivatives to mitochondria	9th International Conference on Skin Ageing & Challenges (Porto, Portugal)
2017/07/04	Drug biophysical profiling using lipid-based colloidal nanosystems and human serum albumin as biomimetic interfaces	VII Iberian Meeting on Colloids and Interfaces (RICI7) (Madrid, Espanha)
2016/11/19	Targeting dietary antioxidants to mitochondria as a therapeutic solution for mitochondrial oxidative stress related diseases	6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept (Budapeste, Hungria)
2016/06/26	Development of bifunctional agents for ameliorating the oxidative stress associated with aging related diseases	36th Edition of the European School of Medicinal Chemistry (ESMEC) (Urbino, Itália)
2016/04/27	Mitohormesis: An attempt by targeting hydroxycinnamic acid derivatives to mitochondria	50th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) (Paris, França)
2016/04/26	Looking for new answers based on natural products for solving bacterial resistance problems	5th Meeting of Young Chemists (PYCheM) / 1st Meeting of Young Chemists (EYCHeM) (Guimarães, Portugal)
2015/07/02	Antioxidants: from Nature to drug prototypes	International Workshop on "Biochemistry, Physiology and Pharmacology of Oxidative Stress (Roma, Itália)
2015/05/13	Design and synthesis of novel antimicrobial agents inspired on phytochemicals	IJUP'15 - 8th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2015/05/08	Caffeic acid: a natural scaffold for the development of new antimicrobial agents	2nd Symposium on Medicinal Chemistry of University of Minho (Braga, Portugal)
2014/06/05	MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria	World Congress on Polyphenols Applications: ISANH Polyphenols (Lisboa, Portugal)
2013/09/27	Makeup of natural antioxidants: Design and development of smart carriers to deliver dietary phenolic acids to mitochondria	3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network Università degli Studi di Cagliari (Cagliari, Itália)
2013/04/17	Development of novel systems to delivery natural antioxidants to mitochondria: MitoCIN’s as a case study	47th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) (Albufeira, Portugal)
2013/02/13	Spergularia rubra: A functional beverage to reduce overweight, obesity and diabetes	IJUP13- 6th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2013/02/13	Bridging the gap between nature and antioxidant therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold	IJUP13- 6th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2013/02/13	Mitocondriotropics derivatives based on the natural polyphenol caffeic acid as a way out for oxidative stress related diseases	IJUP13- 6th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2013/01/09	Development of Smart Carriers for delivering natural antioxidants to Mitochondria	2nd Workshop on Medicinal Chemistry Drug Discovery and Development: Understanding the R&D process Faculty of Sciences of the University of Porto (Porto, Portugal)
2012/03/28	Development of new lipophilic antioxidants based on cinnamic acid	5th Scientific Seminar- 2nd cycle studies in chemistry (FCUP) (Porto, Portugal)
2012/02/22	Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage	IJUP12- 5th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2011/11/09	Striving for success in antioxidant therapy	10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants (Roma, Itália)
2011/10/13	Opening a new avenue in neurodegenerative therapy: Mitochondria targeted antioxidants based on cinnamic scaffold	Angelini University awards 10/11 (Porto, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2023/04 - Atual	De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators Orientador de Carla Lima	Química (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal
2022/10/01 - Atual	Bona fide NOX2 inhibitors: a new therapeutic solution for neurodegenerative diseases Coorientador de Mariana Antunes Castelôa	Química (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal
2023/09 - 2024/09	Desenvolvimento de Novos Quelantes de Ferro Direcionados à Mitocôndria com Potencial Aplicação da Ataxia de Friedreich Orientador de Leticia Soares	Bioquímica (Mestrado) Universidade do Porto Departamento de Química e Bioquímica, Portugal
2023/02 - 2023/09	TAILORING VAS2870 SCAFFOLD TO DEVELOP NEW COVALENT NOX2 INHIBITORS Coorientador de Vera Lúcia Amaral	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2022/11 - 2023/09	Desenvolvimento de novos agentes antibacterianos para combater as infeções hospitalares Orientador de Catarina Alves	Química Medicinal (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/02 - 2023/07	Desenvolvimento novas estratégias para o tratamento da resistência aos antibióticos Orientador de Joana Quadros Ferreira	Bioquímica (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2022/10 - 2023/02	NOX2 como alvo terapêutico para desenvolvimento de novos fármacos para as doenças neurodegenerativas Coorientador de Andreia Ferreira	Bioquímica (Licenciatura/Bacharelato) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2021/09/28 - 2022/12/07	Development of new multitarget-directed ligands with potential application in Alzheimer disease Orientador de Carla Lima	Química (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2021/01 - 2022/12	Toxicological, neuroprotective and permeability evaluation of innovative Antiparkinsonian agents in cellular models Coorientador de Inês Cunha (Master Student)	Toxicologia Analítica Clínica e Forense (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2020/09/14 - 2021/11/15	In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer Coorientador de Mariana Antunes Castelôa	Bioquímica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2021/03 - 2021/09	Evaluation of drug-like properties of innovative multitarget-directed ligands for treatment of Parkinson's disease Orientador de Carolina Cunha	Bioengenharia (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2021/02 - 2021/07	New insights into the development of selective bona fide NOX2 inhibitors Coorientador de Inês Libânio	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2020/02/03 - 2020/09/29	Development of new cationic antioxidants as a tool to tune the cytotoxic profile of mitochondriotropic antioxidants, Extracurricular internship (PEEC program), training in organic synthesis Orientador de Carla Lima	Química (Licenciatura/Bacharelato) Universidade do Porto, Portugal
2020/02/03 - 2020/06/14	Design of smart carriers to target oxidative stress for Alzheimer disease Orientador de Diana Pinho	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2016/12/04 - 2017/12/16	Synthesis of piperazine derivatives as acetylholinesterase inhibitors as a potential treatment of Alzheimer's disease Coorientador de Tânia Moura	Bioquímica (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/11/03 - 2015/07/15	Synthesis of new antioxidants and screening of AChE inhibitors Orientador de João Handel de Oliveira	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2013/01/04 - 2013/06/04	Development of novel antioxidants, Extracurricular internship (PEEC program), training in organic synthesis Coorientador de Ana Francisca Coelho	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2012/06/02 - 2013/01/12	Looking for a therapeutic solution for Parkinson's Disease, Extracurricular internship (PEEC program), training in organic synthesis Coorientador de Andreia Carneiro	Bioquímica (Licenciatura/Bacharelato) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2012/04/18 - 2012/10/22	Looking for a therapeutic solution for Parkinson's Disease, Extracurricular internship (PEEC program), training in organic synthesis Coorientador de Ana Bouçanova	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023/06/26 - 2023/07/12	Co-organizer/Trainer of the international course - Erasmus+ Blended Intensive Programmes : Drug Discovery 2030: A Roadmap for a New Decade (2023/06/26 - 2023/07/12) Conferência (Coorganizador)	Universidade do Porto Faculdade de Ciências, Portugal
2021/05/07 - 2021/05/09	Co-organizer of the First Webinar on Medicinal Chemistry - Designing Tomorrow´s Therapeutic - organized within the framework of the Medicinal Chemistry curricular unit and opened to the scientific community. (2021/05/07) Conferência (Coorganizador)	Universidade do Porto Faculdade de Ciências, Portugal
2020/02/22 - 2020/02/22	II workshop meeting CIQ-UP (Chemistry Research Center of University of Porto) (2020/02/22 - 2020/02/22) Conferência (Membro da Comissão Organizadora)	Universidade do Porto Faculdade de Ciências, Portugal
2018/07/12 - 2018/07/14	VIII Meeting of the Paul Ehrlich MedChem EuroPhD Network & MuTaLig COST Action (2018/07/12 - 2018/07/14) Conferência (Membro da Comissão Organizadora)	Universidade do Porto Faculdade de Ciências, Portugal
2017/09/22 - 2017/09/24	EpiChemBio and 2nd annual MuTaLig COST actions joint meeting (2017/09/22 - 2017/09/24) Conferência (Membro da Comissão Organizadora)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2016/06/29 - 2016/07/01	10th World Congress on Polyphenols Applications (2016/06/26 - 2016/07/01) Conferência (Membro da Comissão Organizadora)	Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2014/05/30 - 2014/05/30	3rd Workshop in Medicinal Chemistry, Drug Discovery and Development: Understanding the R&D Process (2014/05/30 - 2014/05/30) Oficina (workshop) (Membro da Comissão Organizadora)	Universidade do Porto Faculdade de Ciências, Portugal
2014/02/12 - 2014/02/14	IJUP' 14 – 7th Meeting of the young researchers of University of Porto (2014/02/12 - 2014/02/14) Encontro (Membro da Comissão Organizadora)	Universidade do Porto, Portugal
2013/01/09 - 2013/01/09	2nd Workshop on Medicinal Chemistry, Drug Discovery and Development: Understanding the R&D Process (2013/01/09 - 2013/01/09) Oficina (workshop) (Membro da Comissão Organizadora)	Universidade do Porto Faculdade de Ciências, Portugal
2011/06/12 - 2011/06/15	2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery (2011/06/12 - 2011/06/15) Encontro (Membro da Comissão Organizadora)	Universidade do Porto Faculdade de Ciências, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2019/11/01 - Atual	Drug (re-)design guided by biophysical characterization of interactions with biomimetic membranes Congresso	5th International Electronic Conference on Medicinal Chemistry MDPI AG, Suiça
2014 - Atual	Demonstration of the Chemistry and Biochemistry area of Faculty of Sciences, University of Porto in Mostra U. Porto Exposição	Universidade do Porto, Portugal
2023/07/16 - 2023/07/18	XII Meeting of the Paul Ehrlich PhD NetWork Congresso	Aristoteleio Panepistemio Thessalonikes Tmema Pharmakeutikes, Grécia
2023/04/26 - 2023/04/26	Communication, dissemination and exploitation in R&D+i (Research, Development and Innovation) project applications for funding: conceptualization and strategies Oficina (workshop)	Universidade do Porto, Portugal
2023/03/31 - 2023/04/03	ENEQUI - Encontro Nacional de Estudantes de Química Encontro	Universidade do Porto Faculdade de Ciências, Portugal
2022/11/16 - 2022/11/18	XXVI Encontro Galego-Portugués de Química Conferência	Universidade de Santiago de Compostela Facultade de Química, Espanha
2022/10/17 - 2022/10/17	How to protect a research result via patent and how to accommodate this protection in the proposal budget for funding Oficina (workshop)	Universidade do Porto, Portugal
2022/06/06 - 2022/06/07	16th Annual Drug Discovery for Neurodegeneration Conference - Course on Translating Research into Novel Drug Targets Conferência	Alzheimer's Drug Discovery Foundation, Estados Unidos
2022/05/04 - 2022/05/06	Moderator in IJUP22 - 15º Encontro de Investigação Jovem da Universidade do Porto Encontro	Universidade do Porto Centro de Investigação em Química, Portugal
2021/10/07 - 2021/10/08	E-Conference on Innovation in Microbial Control Conferência	Universidade do Porto Faculdade de Engenharia, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2021/09/22 - 2021/09/24	Summer School in Pharmaceutical Analysis 2021: “Analytical methods to achieve efficiency in the hit-to-lead process Conferência	Università degli Studi di Bologna, Itália
2021/07/26 - 2021/07/28	Paul Ehrlich Virtual Meeting 2021 Conferência	Università degli Studi Magna Graecia di Catanzaro, Itália
2021/02/16 - 2021/02/17	1st symposium on Alzheimer Disease: an update on pathology and therapeutics Conferência	Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2021/01/28 - 2021/01/28	Webinar "How to use Microsoft Teams for distance learning activities" Oficina (workshop)	Universidade do Porto Faculdade de Ciências, Portugal
2020/12/01 - 2020/12/01	Webinar "Back to Basics: Fundamental Concepts of HPLC & UHPLC" Oficina (workshop)	VWR Foundation, Estados Unidos
2020/07/30 - 2020/07/30	Webinar "Introducing - Mya 4 Reaction Station for reaction optimisation and process development" Oficina (workshop)	Radleys Team, Reino Unido
2020/07/16 - 2020/07/16	Webinar "Improving cell-based assays and their future in drug discovery" Conferência	Drug Target Review , Alemanha Fraunhofer Institut für Molekularbiologie und Angewandte Oekologie IME Institutsbereich Angewandte Oekologie, Alemanha
2020/03/05 - 2020/03/06	MuTaLig COST ACTION CA1513, 4th WG meeting Congresso	Ege Üniversitesi Eczacilik Fakültesi, Turquia MuTaLig COST ACTION CA1513, Turquia, Turquia
2019/06/13 - 2019/06/15	Paul Ehrlich Euro-PhD Network & MuTaLig COST Action Congresso	Complesso Monumentale San Giovanni, Itália Università degli Studi Magna Graecia di Catanzaro, Itália
2018/12/05 - 2018/12/07	3rd MuTaLig COST Action Training School Outro	Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME Bereich Translationale Medizin Aussenstelle ScreeningPort, Alemanha
2018/10/18 - 2018/10/19	MuTaLig COST ACTION CA1513- WG meeting Congresso	University of Malta, Malta
2017/11/27 - 2017/11/27	International dissemination event of the Toxicology MOOC (massive open online course) in the framework of the Erasmus+ Project TOX-OER- learning toxicology through open educational resources Outro	Universidade do Porto Faculdade de Farmácia, Portugal
2017/09/22 - 2017/09/24	Joint EpiChemBio and MuTaLig COST Actions Meeting Congresso	Universidade do Porto, Portugal
2016/11/19 - 2016/11/20	Mutalig COST Action, 1st WG meeting “Poly-pharmacology expanding Paul Elrlich’s magic bullet concept” Congresso	Novotel Budapest Danube, Hungria
2016/06/26 - 2016/07/01	36th Edition of the European School of Medicinal Chemistry (ESMEC) Congresso	Campus “Collegi del Colle e Tridente”, Itália
2015/02/04 - 2015/02/06	XXII Young Research Fellow Meeting Congresso	Société de Chimie Thérapeutique, França
2014/06/20 - 2014/06/22	4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network Congresso	Univerzita Hradec Králové, República Checa
2014/03/17 - 2014/03/17	European Innovation Master Thesis competition 2017 Concurso	future Ideas
2013/11/13 - 2013/11/15	XIX Galician-Portuguese Chemistry Meeting Congresso	Museu do Mar da Galiza, Espanha
2013/09/04 - 2013/09/06	10th National Meeting of Organic Chemistry and 1st Luso-Brazilian Symposium on Organic Chemistry Simpósio	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/05/17 - 2013/05/17	1st Symposium on Medicinal Chemistry Simpósio	Universidade do Minho, Portugal
2013/05/09 - 2013/05/10	11st National Meeting of Physical Chemistry-11ENQF Simpósio	Sociedade Portuguesa de Química, Portugal
2013/02/13 - 2013/02/15	IJUP’ 13 – 6th Meeting of the young researchers of University of Porto Encontro	Universidade do Porto, Portugal
2012/09/06 - 2012/09/09	16th Biennial Meeting of the Society for Free Radical Research International Congresso	Imperial College London, Reino Unido
2012/05/23 - 2012/05/24	1st Chemical Shifts with the theme: "Química no mundo" Seminário	Universidade do Porto Faculdade de Ciências, Portugal
2012/02/22 - 2012/02/24	IJUP’ 12 – 5th Meeting of the young researchers of University of Porto Encontro	Universidade do Porto, Portugal
2011/10/13 - 2011/10/13	Angelini University awards 10/11 Encontro	Morada Angelini Farmacêutica Lda, Portugal
2011/02/17 - 2011/02/18	IJUP’ 11 – 4th Meeting of the young researchers of University of Porto Encontro	Universidade do Porto, Portugal
2010/12/17 - 2010/12/17	1st workshop in Medicinal Chemistry, Drug Discovery and Development: Understanding the R&D Process Oficina (workshop)	Universidade do Porto Faculdade de Ciências, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2022/12	Toxicological, neuroprotective and permeability evaluation of innovative Antiparkinsonian agents in cellular models Orientador	Inês Cunha (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2022/12	Development of new multitarget-directed ligands with potential application in Alzheimer’s disease Orientador	Carla Lima (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2022/07	Desenvolvimento de novos antibióticos baseados em ácidos benzoico e cinâmico para ameaças bacterianas da saúde pública atual Arguente principal	Mariana da Silva Bastos (BsC student) (Outro) Universidade do Porto Faculdade de Ciências, Portugal
2022/06/23	Targeting Cardiac Mitochondria with a New Generation of Multi-Purpose Cardioprotective Molecules Arguente	Caroline Veloso (Doutoramento) Centre for Neuroscience and Cell Biology , Portugal
2021/10/12	Avaliação das propriedades antioxidantes dos ácidos fenólicos direcionados às mitocôndrias Arguente principal	Beatriz da Silva Gonçalves (Mestrado) Universidade da Beira Interior, Portugal
2021/07/12	Synthesis of new multi-target compounds with therapeutic potential for ALS Arguente principal	Ana Rita Alfenim (BsC student) (Outro) Universidade do Porto Faculdade de Ciências, Portugal
2020/07/21	Development of new bio-based antibiotics for the current public health bacterial threats Arguente principal	Ana Margarida Duarte Pereira (BsC student) (Outro) Universidade do Porto Faculdade de Ciências, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2023 - Atual	Conference scientific committee of the Erasmus+ Blended Intensive Programmes ¿ Drug Discovery 2030: A Roadmap for a New Decade	Faculty of Sciences of University of Porto
2021 - Atual	Conference scientific committee of the First Webinar on Medicinal Chemistry - Designing Tomorrow´s Therapeutic	Faculty of Sciences of the University of Porto
2022/05/04 - 2022/05/06	Conference scientific committee of the IJUP22- 15th meeting of young researchers of University of Porto	Universidade do Porto

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2022/05 - Atual	Peer review in Scientific Reports (2045-2322)	Nature
2021/01 - Atual	Peer review in Molecules (1420-3049)	MDPI
2021 - Atual	Peer review in European Journal of Clinical Investigation (1365-2362)	Wiley
2020/01/18 - Atual	Peer review in Colloids and Surfaces B Biointerfaces (0927-7765)	Elsevier
2020 - Atual	Peer review in Pharmacological Reports (1734-1140)	Springer
2020 - Atual	Peer review in International Journal of Molecular Sciences (1422-0067)	MDPI
2022/09/15 - 2023/05/31	Guest editor in the Special Issue: "Advances in Drug Discovery Research in Europe", Molecules, https://www.mdpi.com/journal/molecules/special_issues/2PSM2TE9VP	MDPI AG
2020/07/07 - 2021/01/31	Guest editor in the Special Issue "Recent Advances in CNS Drug Discovery", Molecules, https://www.mdpi.com/journal/molecules/special_issues/CNS_Drug	MDPI

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2020/02 - Atual	Invited Professor in Medicinal Chemistry classes	Chemistry and Biochemistry (Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal
2023/02 - 2023/07	Project/internship	Química (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2023/02 - 2023/07	Project/internship	Bioquímica (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2022/10 - 2023/02	Project/ internship	Bioquímica (Licenciatura)	Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/02 - 2021/07	Project/internship	Química (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2017/12/06 - 2018	Invited Professor in Bioorganic Chemistry classes	Chemistry and Biochemistry (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2014/03/03 - 2014/05/05	Assistent in practical classes of Medicinal Chemistry	Chemistry and Biochemistry (Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal

Entrevista / Programa (rádio / tv)

	Programa	Tema
2023/04/04 - Atual	SIC Notícias	Portuguese researchers develop antioxidant to fight neurodegenerative diseases
2023/04/04 - Atual	Jornal de Notícias	FCUP develops antioxidant with potential to fight neurodegenerative diseases
2023/04/04 - Atual	Diário de Notícias	New developed antioxidant with potential to fight neurodegenerative diseases
2023/04/04 - Atual	Radio Renascença	FCUP develops antioxidant with potential to fight neurodegenerative diseases
2023/04/04 - Atual	CNN Portugal	Portuguese researchers develop antioxidant with potential to fight neurodegenerative diseases
2023/03/16 - Atual	Notícias U.Porto and FCUP	How Lego Chemistry can help to fight neurodegenerative diseases
2018/06/06 - Atual	UP Inovação - Mitotag	The use of antioxidants as a solution to fight age related diseases

Membro de associação

	Nome da associação	Tipo de participação
2022/03/11 - Atual	PT-OPENSCREEN - NORTE-01-0145-FEDER-085468: "Infraestrutura Nacional para a Química Biológica e Genética"
2022/03/11 - Atual	EU-OPENSCREEN- European Research Infrastructure Consortium for chemical biology and early drug discovery
2013 - Atual	Sociedade Portuguesa em Química
2011 - Atual	Associate Laboratory - CIQUP/IMS - Institute of Molecular Sciences Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto
2016/04/18 - 2020/10/17	MuTaLig COST ACTION CA15135
2015/03/24 - 2019/03/23	EPICHEM Cost Action CM1406

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2023/03/20 - 2023/03/31	Effective member of the jury for the attribution of research grant (Pos-doc) under the project UIDB/00081/2020-RG1 to discover and develop new chemical entities with therapeutic potential for neurodegenerative and/or infectious diseases	Universidade do Porto Faculdade de Ciências, Portugal
2022/06/09 - 2022/06/27	Effective member of the jury for the attribution of research grant (Master degree) under the project "A Trojan horse strategy to discover and develop new antibacterials for superbugs" (EXPL/MED-QUI/1156/2021)	Universidade do Porto Faculdade de Ciências, Portugal
2019/10/30 - 2019/11/13	Effective member of the jury for the attribution of research grant (Master degree) under the project "SkinSHIELD 2" (POCI-01-0145-FEDER-028607)	Universidade do Porto Faculdade de Ciências, Portugal

Tutoria

	Tópico	Nome do aluno
2020/12/03 - Atual	Dual-acting drugs targeting Ferroptosis and COMT: a new potential therapeutic strategy to fight Parkinson's Disease	Vera Silva (PhD Student)
2021/03/03 - 2024/02/01	Mitochondria-target antioxidants as novel therapeutics for Amyotrophic Lateral Sclerosis: Regulating Oxidative Stress and Apoptosis through modulation of the NFkB/HIF-1a axis	Cátia Silva Soares (PhD Student)
2023/04 - 2023/12	Biological evaluation of chemical compounds as anticancer and antioxidant agents	Jessica Ceramella - University of Calabria, Italy
2022/09 - 2023/06	Evaluation of iron chelation and cellular cytotoxicity of bioactive compounds	Uxia Bouzó (PhD student) - University of Vigo, Spain
2022/10/15 - 2023/05/14	Design and synthesis of new chemical entities based on VAS2870. BSc fellowship. Project NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure (EXPL/BIA-BQM/0492/2021) (7 months).	Carla Lima
2022/05/01 - 2022/09/30	Tailoring VAS27870 scaffold to develop new covalent NOX2 inhibitors. MSc fellowship (5 months). Project NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure (EXPL/BIA-BQM/0492/2021).	Mariana Antunes Castelôa
2022/04 - 2022/07	Development of antioxidants directed to mitochondria	Marco Francescato (Master student) - University of Bologna, Italy
2019/12/01 - 2020/12/01	Uso de fitoquímicos redox-activos para desencadear a hormesis mitocondrial: Desenvolvimento de uma nova geração de ingredientes para a cosmética	Brandon Aguiar (MsC fellow)
2019/09/02 - 2019/11/29	Short-Term Scientific Mission (STSM) of Cost Action CA15135 "Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig) in Chemistry	Jan Konecny (PhD student)- Univerzity of Pardubice, Czech Republic
2014/05/01 - 2015/05/31	Desenvolvimento de novos inibidores das proteínas quinases: um contributo para o tratamento da Esclerose Lateral Amiotrófica	Diogo Magalhães e Silva (BsC degree)

Distinções

Prémio

2024	Best article Prize (Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier) in IACOBUS-Papers cross-border scientific collaboration between the northern region of Portugal and Galicia Xunta de Galicia, Espanha
2022	Best Poster Communication Prize in 56th Annual Scientific Meeting, European Society for Clinical Investigation (ESCI), Itay, Bari
2022	Best Poster Communication Prize in X Meeting of the Paul Ehrlich Euro-PhD Network, Barcelona, Spain
2022	Research Fund: Principal Investigator of the FCT Project: "De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators" (2022.04633.PTDC) Fundação para a Ciência e a Tecnologia, Portugal
2021	Best article Prize (Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer’s Disease Pathophysiol) in IACOBUS-Papers cross-border scientific collaboration between the northern region of Portugal and Galicia Xunta de Galicia, Espanha
2021	Research Fund: Co-Principal Investigator of the FCT Project: "Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure" (EXPL/BIA-BQM/0492/2021 Fundação para a Ciência e a Tecnologia, Portugal
2020	Conference Grant from COST ACTION CA15135, Izmir, Turkey European Cooperation in Science & Technology , Izmir, Turquia
2020	Best Poster Communication Prize in Mu.Ta.Lig – COST ACTION CA15135, Izmir, Turkey MuTaLig COST ACTION CA1513, Turquia, Turquia
2020	Best Oral Communication Prize in Mu.Ta.Lig COST ACTION CA15135, Izmir, Turkey MuTaLig COST ACTION CA1513, Turquia, Turquia
2019	Best Poster Communication Prize in Mu.Ta.Lig – COST ACTION CA15135, Paris, France MuTaLig COST ACTION CA1513, França
2019	Conference Grant from COST ACTION CA15135 in conjunction with the Paul Ehrlich Euro-PhD Network, Catanzaro, Italy European Cooperation in Science & Technology , Catanzaro, Itália
2018	Conference Grant from COST ACTION CA15135, Valletta, Malta European Cooperation in Science & Technology , Valletta, Malta
2018	Course and Travel Grant: Grant for Cost Action multi-targeting biophysical training school to cover registration, accommodation and travel expenses at Fraunhofer- IME, Hamburg, Germany Fraunhofer-Verbund IUK-Technologie, Alemanha
2018	Best Poster Communication Prize in European Society for Clinical Investigation, Barcelona, Spain
2016	Best Poster Communication Prize in European School of Medicinal Chemistry, Urbino, Italy 36th Edition of European School of Medicinal Chemistry, Itália
2016	Course and Travel Grant: Grant for European School of Medicinal Chemist0ry (ESMEC) to cover registration, accommodation and travel expenses at Campus Collegi del Colle e Tridente, Urbino, Italy 36th Edition of European School of Medicinal Chemistry, Itália
2014	Career Grant: International Individual PhD Fellowship (SFRH/BD/99189/2013) (PT) Fundação para a Ciência e a Tecnologia, Portugal

Título

2019	Paul Ehrlich MedChem Euro-PhD in Medicinal Chemistry Label
2018	European Doctorate Universidade do Porto Faculdade de Ciências, Portugal

Outra distinção

2022	Project Research Grant NORTE-01-0145-FEDER-085468 (PT)
2019	Project Research Grant POCI-01-0145-FEDER-029164 (PT)
2018	CCRN Fellowship NORTE-01-0145-FEDER-000028 (PT)
2018	Project Research Grant POCI-01-0145-FEDER-028607 (PT)
2013	FCT Fellowship PTDC/AGR-AAM/105044/2008 (PT)
2012	Erasmus Research Undergraduate Fellowship (EU) Universidade de Santiago de Compostela, Espanha