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Ricardo Jorge Leal Silvestre. Completed the Doutoramento in PhD in Pharmaceutical Sciences in the discipline of Biochemistry in 2007/12/13 by Universidade do Porto Faculdade de Farmácia and Licenciatura in Ciências Farmacêuticas in 2003/06/22 by Universidade do Porto Faculdade de Farmácia. Is Principal Investigator in Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde. Published 96 articles in journals. Has 6 section(s) of books and 1 book(s). Has 3 patent(s) registered. Organized 4 event(s). Supervised 7 PhD thesis(es) e co-supervised 9. Supervised 5 MSc dissertation(s) e co-supervised 5. Supervised 8 work(s) of course completion of LSc/BSc e co-supervised 1. Has received 4 awards and/or honors. Participates and/or participated as PhD Student Fellow in 1 project(s), Principal investigator in 10 project(s) and Researcher in 10 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Health Sciences. In their professional activities interacted with 543 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Sirtuins; Leishmania; Immune response; Host-pathogen interaction; vaccine; Immunotherapy; Mitochondrial dynamics and biogenesis; Macrophages; Dendritic cells; Cytokines; Metabolism; Epigenetics; Leishmania; Proteína reguladora do silenciamento de gene; Resposta imunológica; Dissertações de doutoramento; .
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Identificação

Identificação pessoal

Nome completo
Ricardo Jorge Leal Silvestre

Nomes de citação

  • Silvestre, Ricardo
  • Leal-Silvestre, RJ

Identificadores de autor

Ciência ID
FC10-05F4-581C
ORCID iD
0000-0002-9270-2717

Endereços de correio eletrónico

  • ricardosilvestre@med.uminho.pt (Profissional)

Telefones

Telefone
  • 253604811 (Profissional)

Moradas

  • Microbiology and Infection Research Domain Life and Health Sciences Research Institute (ICVS): School of Medicine; University of Minho. Campos de Gualtar , 4710-057 , Braga, Braga, Portugal (Profissional)

Websites

  • http://www.researchgate.net/profile/Ricardo_Silvestre (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2007/12/13
Concluído
 PhD in Pharmaceutical Sciences in the discipline of Biochemistry (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Leishmania SIR2: Host cells interaction and vaccinal approach" (TESE/DISSERTAÇÃO)
 Approved unanimously
2003/06/22
Concluído
 Ciências Farmacêuticas (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
"_" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/07/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/07/01 - 2020/06/30 Investigador Auxiliar (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010/01/01 - 2014/06/30 Investigador Auxiliar (carreira) (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008/01/01 - 2009/12/31 Pós-doutorado (Investigação) Université Paris-Est Créteil Val de Marne Faculté de médecine, França
2003/10/01 - 2003/12/01 Estagiário de Investigação (Investigação) Institut de Recherche pour le Développement Délégation Régionale Occitanie, França
2003/01/01 - 2003/07/01 Estagiário de Investigação (Investigação) Institut Pasteur, França
2000/03/01 - 2002/10/01 Estagiário de Investigação (Investigação) Universidade do Porto Faculdade de Farmácia, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/09/01 - 2021/08/30 Professor Auxiliar Convidado (Docente Universitário) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011/10/01 - 2014/06/30 Professor Auxiliar Convidado (Docente Universitário) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2004/01/01 - 2007/12/01 PhD student Universidade do Porto Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2023/04/01 - Atual Elucidating the role of apoptotic T cell death in Post-COVID-19 condition
APO-PCC
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 2CA-Braga
Em curso
2021/03 - 2024/02 Elucidation of the Functional Roles of Lipid Metabolism During Canine Leishmaniasis
PTDC/CVT-CVT/4808/2020
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2018/07 - 2021/06 Immunological basis of failure in controlling Mycobacterium tuberculosis infection.
PTDC/SAU-INF/28463/2017.
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/07 - 2021/06 Immunometabolic Networks in the Regulation of Visceral Leishmaniasis
Project INLEISH
Investigador responsável
European Commission Seventh Framework Programme for Research and Technological Development
2019/06/01 - 2021/05/31 YoGut: a functional yogurt to prevent intestinal inflammation
Yogut
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluído
2019/04/01 - 2021/03/31 Feeding immunity: development of new nutraceuticals for visceral leishmaniasis
ESCMID Research Grant 2019
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 European Society of Clinical Microbiology and Infectious Diseases
Concluído
2018/04/01 - 2021/03/31 Immunometabolic networks for biomarker and therapy assessment in inflammatory disease
IMBIOM
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluído
2016/04 - 2020/03 New avenues for the development of personalized medical interventions for neurological, oncologic and surgical disorders
NORTE-45-2015-02
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Em curso
2019/01 - 2019/12 Strategic Project Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group (LA ICVS/3Bs 2019)
UID/Multi/50026/2019
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/04 - 2018/05 Exploring the role of mesenchymal stem cells-mediated reprogramming of macrophages in rheumatoid arthritis.
MEMoRA
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluído
2012/05 - 2015/09 Cell communication by Leishmania microvesicles
grant.Provided by PTCRIS: 118644
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2011/04 - 2014/06 Development of a new immunological screening method for leishmaniasis using colloidal gold nanoparticles
grant.Provided by PTCRIS: 110732
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/09 Implication of sirtuin proteins in the regulation of antigen presenting cells apoptosis during leishmaniasis: a therapeutic approach
grant.Provided by PTCRIS: 100749
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/09 Role and mechanism of action of immunoregulatory iNKT and DC cells in Leishmania infection: new approaches for vaccination?
grant.Provided by PTCRIS: 101017
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2009/02 - 2013/01 Le rôle des sirtuins dans la modulation de la mort des cellules présentatrices de l'antigène au cours de la leishmaniose viscérale
LEISH-APO
Investigador
Institut Mondor de recherche biomédicale, França
 Agence nationale de la recherche
Concluído
2007/11 - 2010/12 The Leishmania TDR1 family-related gene: functional studies and evaluation of TDR1 recombinant protein and knockout vaccines against leishmaniasis.
grant.Provided by PTCRIS: 65047
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2007/08 - 2009/12 ROLE OF DENDRITIC CELLS IN LEISHMANIASIS: intracellular signalling pathways activated by virulent and attenuated parasite Leismania infantum
grant.Provided by PTCRIS: 67351
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2007/01 - 2009/02 ANTI-LEISHMANIAL DRUGS: study the role of novel polyamine derivative compounds for drug therapy and search for target specific SIR2 inhibitors
grant.Provided by PTCRIS: 82728
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2005/07 - 2008/06 The Leishmania SIR2 family-related gene: functional studies and evaluation of SIR2 recombinant DNA and knockout vaccine to protect against Leishmnaniasis
grant.Provided by PTCRIS: 59840
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2005/07 - 2007/08 ANTI-LEISHMANIAL DRUGS: study the role of novel polyamine derivative compounds for drug therapy and search for target specific SIR2 inhibitors
grant.Provided by PTCRIS: 59837
Investigador
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2015/07/01 - 2020/06/30 Subversion of the host cell energy metabolism by intracellular pathogens: implications on immunity and innovative immunotherapeutic approaches
IF/00021/2014
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em jornal
  1. Silvestre, Ricardo. "Molécula IL-6 dá indicação da evolução dos doentes Covid", Correio do Minho, 2021, https://correiodominho.pt/noticias/molecula-il-6-da-indicacao-da-evolucao-dos-doentes-covid/129344.
  2. Silvestre, Ricardo. "Medir regularmente a quantidade da molécula IL-6 ajuda a antecipar e combater a Covid-19", TSF, 2021, https://www.tsf.pt/portugal/sociedade/medir-regularmente-a-quantidade-da-molecula-il-6-ajuda-a-antecipar-e-combater-a-covid-19-13395009.html.
  3. Silvestre, Ricardo. "Parasita da leishmaniose torna-nos cúmplices da sua infecção", Público, 2013, https://www.publico.pt/2013/08/30/jornal/parasita-da-leishmaniose-tornanos-cumplices-da-sua-infeccao-27008571.
Artigo em revista
  1. Matheus Tavares; Jorge Carlos Sousa-Filho; Ian Alves Machado; Relber Aguiar Gonçales; Daniela Antunes; Ana Mendes-Frias; Ricardo Silvestre; et al. "Development of a Versatile Toolbox for Genetic Manipulation of Sporothrix brasiliensis". Microbiology Spectrum (2023): https://doi.org/10.1128/spectrum.04564-22.
    10.1128/spectrum.04564-22
  2. Daniela Antunes; Samuel M. Gonçalves; Vasiliki Matzaraki; Cláudia S. Rodrigues; Relber A. Gonçales; Joana Rocha; Jorge Sáiz; et al. "Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus". Microbiology Spectrum (2023): https://doi.org/10.1128/spectrum.02256-22.
    10.1128/spectrum.02256-22
  3. da Silva-Ferreira S; Duarte-Oliveira C; Antunes D; Barbosa-Matos C; Mendes-Frias A; Torrado E; Costa S; et al. "Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation.". Frontiers in cellular and infection microbiology (2022): http://europepmc.org/abstract/med/36275017.
    10.3389/fcimb.2022.1005839
  4. Mendes-Frias A; Gallo V; Iacobelli V; Gentile R; Antonini G; Silvestre R; Iacobelli S. "Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell lines.". Scientific reports (2022): http://europepmc.org/abstract/med/36220879.
    10.1038/s41598-022-20852-x
  5. Diana Luísa Almeida-Nunes; Ana Mendes-Frias; Ricardo Silvestre; Ricardo Jorge Dinis-Oliveira; Sara Ricardo. "Immune Tumor Microenvironment in Ovarian Cancer Ascites". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231810692.
    10.3390/ijms231810692
  6. André S; Azarias da Silva M; Picard M; Alleaume-Buteau A; Kundura L; Cezar R; Soudaramourty C; et al. "Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients.". Cell death & disease (2022): http://europepmc.org/abstract/med/36030261.
    10.1038/s41419-022-05190-0
  7. Ferreira CM; Micheli C; Barreira-Silva P; Barbosa AM; Resende M; Vilanova M; Silvestre R; et al. "IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection.". Frontiers in immunology (2022): http://europepmc.org/abstract/med/35935958.
    10.3389/fimmu.2022.946181
  8. Morgane Picard; Calaiselvy Soundaramourty; Ricardo Silvestre; Jérôme Estaquier; Sónia André. "Leishmania infantum Infection of Primary Human Myeloid Cells". Microorganisms 10 6 (2022): 1243-1243. https://doi.org/10.3390/microorganisms10061243.
    10.3390/microorganisms10061243
  9. Gonçales RA; Bastos HN; Duarte-Oliveira C; Antunes D; Sokhatska O; Jacob M; Rolo R; et al. "PTX3 Inhibits Complement-Driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis.". American journal of respiratory and critical care medicine (2022): http://europepmc.org/abstract/med/35767663.
    10.1164/rccm.202112-2771oc
  10. Abdulghani S; Afonso Â; Castillo M; Martín-Fernández J; Franco I; Parreira B; Couto A; et al. "The Role of Biobanks in the Fight against COVID-19 Pandemic: The Portuguese Response.". Acta medica portuguesa (2022): http://europepmc.org/abstract/med/35522822.
    10.20344/amp.17856
  11. Cardoso M; Gaspar VM; Ferreira C; Silvestre RS; Duarte IF; Mano JF. "Macrophage-targeted shikonin-loaded nanogels for modulation of inflammasome activation.". Nanomedicine : nanotechnology, biology, and medicine (2022): http://europepmc.org/abstract/med/35301158.
    10.1016/j.nano.2022.102548
  12. "T cell apoptosis characterizes severe Covid-19 disease". Cell Death & Differentiation (2022): http://dx.doi.org/10.1038/s41418-022-00936-x.
    Publicado • 10.1038/s41418-022-00936-x
  13. Carolina Ferreira; Jérôme Estaquier; Ricardo Silvestre. "Immune-metabolic interactions between Leishmania and macrophage host". Current Opinion in Microbiology (2021): https://doi.org/10.1016/j.mib.2021.07.012.
    10.1016/j.mib.2021.07.012
  14. Catarina M. Ferreira; Ana Margarida Barbosa; Palmira Barreira-Silva; Ricardo Silvestre; Cristina Cunha; Agostinho Carvalho; Fernando Rodrigues; et al. "Early IL-10 promotes vasculature-associated CD4+ T cells unable to control Mycobacterium tuberculosis infection". JCI Insight (2021): https://doi.org/10.1172/jci.insight.150060.
    10.1172/jci.insight.150060
  15. Silvestre, Ricardo. "Nutritional adjuvants with antioxidant properties in the treatment of canine leishmaniasis.". Veterinary parasitology (2021): https://doi.org/10.1016/j.vetpar.2021.109526.
    10.1016/j.vetpar.2021.109526
  16. Santa Cruz, A.; Mendes-Frias, A.; Oliveira, A.I.; Dias, L.; Matos, A.R.; Carvalho, A.; Capela, C.; et al. "Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia". Frontiers in Immunology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102130540&partnerID=MN8TOARS.
    10.3389/fimmu.2021.613422
  17. Shukla, D.; Patidar, A.; Sarma, U.; Chauhan, P.; Pandey, S.P.; Chandel, H.S.; Bodhale, N.; et al. "Interdependencies between Toll-like receptors in Leishmania infection". Immunology (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106570265&partnerID=MN8TOARS.
    10.1111/imm.13364
  18. Ohms, M.; Ferreira, C.; Busch, H.; Wohlers, I.; Guerra de Souza, A.C.; Silvestre, R.; Laskay, T.. "Enhanced Glycolysis Is Required for Antileishmanial Functions of Neutrophils Upon Infection With Leishmania donovani". Frontiers in Immunology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103584189&partnerID=MN8TOARS.
    10.3389/fimmu.2021.632512
  19. Varjão, B.M.; Pinho, F.A.; Solcà, M.D.S.; Silvestre, R.; Fujimori, M.; Goto, H.; Varjão, N.M.; Dias, R.C.; Barrouin-Melo, S.M.. "Spatial distribution of canine Leishmania infantum infection in a municipality with endemic human leishmaniasis in Eastern Bahia, Brazil". Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria 30 2 (2021): e022620-e022620. http://www.scopus.com/inward/record.url?eid=2-s2.0-85107399821&partnerID=MN8TOARS.
    10.1590/S1984-29612021034
  20. Silvestre, Ricardo. "Mimicking Behcet's disease: GM-CSF gain of function mutation in a family suffering from a Behcet's disease-like disorder marked by extreme pathergy.". Clinical and experimental immunology (2020): https://doi.org/10.1111/cei.13568.
    10.1111/cei.13568
  21. Sonia André; Vasco Rodrigues; Morgane Picard; Ricardo Silvestre; Jérôme Estaquier. "Non-human primates and Leishmania immunity". Cytokine: X 2 4 (2020): 100038-100038. https://doi.org/10.1016/j.cytox.2020.100038.
    10.1016/j.cytox.2020.100038
  22. de Sousa Gonçalves, Rafaela; Alves de Pinho, Flaviane; Dinis-Oliveira, Ricardo Jorge; Azevedo, Rui; Gaifem, Joana; Larangeira, Daniela Farias; Ramos-Sanchez, Eduardo Milton; et al. "Mathematical Modelling Using Predictive Biomarkers for the Outcome of Canine Leishmaniasis upon Chemotherapy". Microorganisms 8 5 (2020): 745. http://dx.doi.org/10.3390/microorganisms8050745.
    10.3390/microorganisms8050745
  23. Mendes-Frias, Ana; Santos-Lima, Bruno; Sousa Furtado, Danielle Zildeana; Ruperez, Francisco J.; Assunção, Nilson Antonio; Matias, Maria João; Gomes, Vânia; et al. "Dysregulation of glycerophospholipid metabolism during Behçet's disease contributes to a pro-inflammatory phenotype of circulating monocytes". Journal of Translational Autoimmunity (2020): 100056. http://dx.doi.org/10.1016/j.jtauto.2020.100056.
    10.1016/j.jtauto.2020.100056
  24. Jha, Mukesh Kumar; Sarode, Aditya Y.; Bodhale, Neelam; Mukherjee, Debasri; Pandey, Surya Prakash; Srivastava, Neetu; Rub, Abdur; et al. "Development and Characterization of an Avirulent Leishmania major Strain". The Journal of Immunology 204 10 (2020): 2734-2753. http://dx.doi.org/10.4049/jimmunol.1901362.
    10.4049/jimmunol.1901362
  25. Ferreira, Nathalia; Mesquita, Inês; Baltazar, Fátima; Silvestre, Ricardo; Granja, Sara. "IL-17A and IL-17F orchestrate macrophages to promote lung cancer". Cellular Oncology (2020): http://dx.doi.org/10.1007/s13402-020-00510-y.
    10.1007/s13402-020-00510-y
  26. Ferreira, Carolina; Mesquita, Inês; Barbosa, Ana Margarida; Osório, Nuno Sampaio; Torrado, Egídio; Beauparlant, Charles-Joly; Droit, Arnaud; et al. "Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis". PLOS Neglected Tropical Diseases 14 3 (2020): e0008125. http://dx.doi.org/10.1371/journal.pntd.0008125.
    10.1371/journal.pntd.0008125
  27. Mesquita, Inês; Ferreira, Carolina; Moreira, Diana; Kluck, George Eduardo Gabriel; Barbosa, Ana Margarida; Torrado, Egídio; Dinis-Oliveira, Ricardo Jorge; et al. "The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis". Cell Reports 30 12 (2020): 4052-4064.e7. http://dx.doi.org/10.1016/j.celrep.2020.02.098.
    10.1016/j.celrep.2020.02.098
  28. Bodhale, N.; Ohms, M.; Ferreira, C.; Mesquita, I.; Mukherjee, A.; André, S.; Sarkar, A.; et al. "Cytokines and metabolic regulation: A framework of bidirectional influences affecting Leishmania infection". Cytokine (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090489171&partnerID=MN8TOARS.
    10.1016/j.cyto.2020.155267
  29. Saha, B.; Silvestre, R.. "Cytokines in the immunity and immunopathogenesis in leishmaniases". Cytokine (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85094586163&partnerID=MN8TOARS.
    10.1016/j.cyto.2020.155320
  30. Gonçalves, S.M.; Duarte-Oliveira, C.; Campos, C.F.; Aimanianda, V.; ter Horst, R.; Leite, L.; Mercier, T.; et al. "Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity". Nature Communications 11 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85084721395&partnerID=MN8TOARS.
    10.1038/s41467-020-16120-z
  31. Gressler, Markus; Heddergott, Christoph; N'Go, Inés C.; Renga, Giorgia; Oikonomou, Vasilis; Moretti, Silvia; Coddeville, Bernadette; et al. "Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus". Frontiers in Cellular and Infection Microbiology 9 (2019): http://dx.doi.org/10.3389/fcimb.2019.00365.
    10.3389/fcimb.2019.00365
  32. Daniela F. Rodrigues; Vera M. Costa; Ricardo Silvestre; Maria L. Bastos; Félix Carvalho. "Methods for the analysis of transcriptome dynamics". Toxicology Research 8 5 (2019): 597-612. https://doi.org/10.1039/c9tx00088g.
    10.1039/c9tx00088g
  33. Campos, Cláudia F.; Leite, Luís; Pereira, Paulo; Vaz, Carlos Pinho; Branca, Rosa; Campilho, Fernando; Freitas, Fátima; et al. "PTX3 Polymorphisms Influence Cytomegalovirus Reactivation After Stem-Cell Transplantation". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.00088.
    Acesso aberto • 10.3389/fimmu.2019.00088
  34. Pérez-Cabezas B; Santarém N; Cecílio P; Silva C; Silvestre R; A M Catita J; Cordeiro da Silva A. "More than just exosomes: distinct Leishmania infantum extracellular products potentiate the establishment of infection.". Journal of extracellular vesicles (2018): http://europepmc.org/abstract/med/30455859.
    10.1080/20013078.2018.1541708
  35. Gaifem J; Gonçalves LG; Dinis-Oliveira RJ; Cunha C; Carvalho A; Torrado E; Rodrigues F; et al. "L-Threonine Supplementation During Colitis Onset Delays Disease Recovery.". Frontiers in physiology (2018): http://europepmc.org/abstract/med/30233416.
    10.3389/fphys.2018.01247
  36. Mesquita I; Ferreira C; Barbosa AM; Ferreira CM; Moreira D; Carvalho A; Cunha C; et al. "The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis.". Cytokine (2018): http://europepmc.org/abstract/med/30017388.
    10.1016/j.cyto.2018.07.001
  37. Mireille Laforge; Ricardo Silvestre; Vasco Rodrigues; Julie Garibal; Laure Campillo-Gimenez; Shahul Mouhamad; Valérie Monceaux; et al. "The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques". Journal of Clinical Investigation 128 4 (2018): 1627-1640. https://doi.org/10.1172/JCI95127.
    10.1172/JCI95127
  38. Carvalho-Gontijo R; Moreira DR; Resende M; Costa-Silva MF; Peruhype-Magalhães V; Ribeiro CMF; Ribeiro DD; et al. "Infection of hematopoietic stem cells by Leishmania infantum increases erythropoiesis and alters the phenotypic and functional profiles of progeny.". Cellular immunology (2017): http://europepmc.org/abstract/med/29248120.
    10.1016/j.cellimm.2017.10.016
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Capítulo de livro
  1. Moreira D; Estaquier J; Cordeiro-da-Silva A; Silvestre R; Moreira, Diana; Estaquier, Jérôme; Cordeiro-da-Silva, Anabela; Silvestre, Ricardo. "Evaluating the Role of Host AMPK in Leishmania Burden.". In Methods in molecular biology (Clifton, N.J.), 551-563. Springer New York, 2018.
    10.1007/978-1-4939-7598-3_35
  2. Silvestre, Ricardo. "O Sistema Imunológico como alvo da toxicidade dos xenobióticos". In Toxicologia Fundamental, 201-218. 2018.
  3. Mesquita I; Vergnes B; Silvestre R. "Alterations on Cellular Redox States upon Infection and Implications for Host Cell Homeostasis.". In Experientia supplementum (2012), 197. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-74932-7_4
  4. Moreira D; Estaquier J; Cordeiro-da-Silva A; Silvestre R. "Metabolic Crosstalk Between Host and Parasitic Pathogens.". In Experientia supplementum (2012), 421-458. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-74932-7_12
  5. Silvestre, Ricardo; Mesquita, I.; Moreira, D.; Sampaio-Marques, B.; Laforge, M.; Cordeiro-da-Silva, A.; Ludovico, P.; Estaquier, J.; Silvestre, R.. "AMPK in Pathogens". In AMP-activated Protein Kinase, Experientia Supplementum, 287-323. 2016.
    Publicado
  6. Silvestre, Ricardo. "Imunologia da Infecção". In Fundamentos de Imunologia, 427-454. 2012.
    Publicado
Livro
  1. Silvestre, Ricardo. Metabolic Interaction in Infection. Springer International Publishing. 2018.
    Publicado • 10.1007/978-3-319-74932-7
Pré-impressão
  1. Mendes-Frias A; Gallo V; Iacobelli V; Gentile R; Antonini G; Silvestre R; Iacobelli S. "Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell lines". 2022. http://europepmc.org/abstract/PPR/PPR476383.
    10.21203/rs.3.rs-1458420/v1
Tese / Dissertação
  1. Silvestre, Ricardo Jorge Leal. "Leishmania SIR2 : host cell interactions and vaccinal approaches". Doutoramento, 2007. http://hdl.handle.net/10216/64002.

Artística / Interpretação

Programa de rádio / tv
  1. RTP. 2021. "RTP". Portugal em Direto.

Propriedade Intelectual

Patente
  1. CT/EP2021/081014. 2021. "LGALS3BP as a diagnostic, prognostic, and therapeutic biomarker in COVID-19 and other cytokine storm conditions.". Portugal.
    Concedida/Emitida
  2. Silvestre, Ricardo. 2016. "Use of polymyxin as an antidote for intoxications by amatoxins (International Patent)".
  3. Silvestre, Ricardo. 2015. "Use of polymyxin as an antidote for intoxications by amatoxin (National Patent)". Portugal.
    Permitida
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022 Elucidation of the functional roles of lipid metabolism during visceral Leishmania infection 3rd International Caparica Conference on Leishmaniasis 2022, 24th–26th October 2022, Caparica, Portugal.
(Caparica, Portugal)
2021/12/09 Immunometabolic networks regulating host-pathogen interactions Unité INSERM U1141/NeuroDiderot Hôpital Robert DEBRÉ December 09, 2021, Paris, France.
2021/04/29 Biomarkers for predicting COVID-19 disease severity. International Immunology Day: Advances on the Immune Responses during COVID-19, April 29, 2021, Online
2019/06/12 Leishmaniose na Europa: da epidemiologia à pesquisa.
Universidade Federal da Bahia (Salvador, Brasil)
2019/05 Immunometabolic networks in the regulation of visceral leishmaniasis XLV Annual Meeting of the Portuguese Society for Immunology
(Coimbra, Portugal)
2018/06/08 Immunometabolic networks regulating host-pathogen interactions TOLL 2018 Editing Innate Immunity
(Porto, Portugal)
2018/04/27 Immunometabolic networks regulating host-pathogen interactions Seminars CICECO
CICECO - Universidade de Aveiro (Aveiro)
2018/04/09 Immunometabolic networks regulating host-pathogen interactions Seminars@CEDOC
CEDOC (Lisboa, Portugal)
2018/03 HIF-1a induction suppresses lipid accumulation in myeloid cells and protects against Leishmania donovani infection TwinnToInfect Spring School
(Sesimbra, Portugal)
2017/11/13 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis. ICVS Ciência Falada.
(Braga, Portugal)
2017/11/09 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis. VI PhDOC Annual Meeting
(Lisboa, Portugal)
2017/10/16 Modulation of host metabolism: new insights into immune evasion by Leishmania parasites International Conference “Immunometabolic Networks in the Regulation of Infection
(Lubeck, Alemanha)
2017/09/26 Lessons from live attenuated vaccines Summer School: Approaches for developing anti-Leishmania vaccines
I3S (Porto, Portugal)
2017/06 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis ICVS Open Day
(Braga, Portugal)
2017/06 HIF-1a induction supresses lipid accumulation in myeloid cells and protects against Leishmania donovani infection XLIII Annual Meeting of the Portuguese Society of Immunology
(Porto, Portugal)
2017/06 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis XLIII Annual Meeting of the Portuguese Society for Immunology
(Porto, Portugal)
2017/05/27 Modulation of host metabolism: new insights into immune evasion by Leishmania parasites XV Congress of the Sociedade Iberica de Citometria
Sociedad Ibérica de Citometria (Lisboa, Portugal)
2016/07/06 Metabolic reprogramming in macrophages: A role in infection and inflammation International Seminars
UC-Biotech - Cantanhede (Cantanhede, Portugal)
2015/10 IL-17 modulated macrophage metabolism: a role in cancer and inflammation. XLI Annual Meeting of the Portuguese Society for Immunology
(Braga, Portugal)
2015/09/15 AMPK on the core of host-pathogen metabolic coupling 2nd European Workshop on AMPK
(Maastricht, Países Baixos)
2015/04/21 Metabolic modulation of the host: new perspectives on Leishmania evasion mechanisms 3º Congresso Nacional de Medicina Tropical e o 1º Congresso Lusófono de Doenças Transmitidas por Vetores. Instituto de Higiene e Medicina Tropical.
Instituto de Higiene e Medicina Tropical. (Lisboa, Portugal)
2015/02/09 Modulation of host metabolism: new insights into immune evasion by intracellular pathogens Ciência Falada
Universidade do Minho (Braga, Portugal)
2014/05/20 Cellular Metabolism and Immunological Evasion Conference on Oncobiology
Universidade do Porto Faculdade de Farmácia (Porto, Portugal)
2014 Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis. XL Annual Meeting of the Portuguese Society for Immunology XL Annual Meeting of the Portuguese Society for Immunology
(Lisboa, Portugal)
2013/06 Leishmania:Immunity ESCMID Postgraduate Technical Workshop Technical Workshop for Basic and Clinical Parasitology
(Porto, Portugal)
2013/05/28 Subvertion of host immune responses during Leishmania infection Ciência Falada
ICVS-Universidade do Minho (Braga, Portugal)
2013/05 Abortive T follicular helper differentiation and loss of activated memory B cells underlie the poor parasite-specific IgG production in Leishmania infantum-infected Rhesus macaques FIFTH WORLD CONGRESS ON LEISHMANIASIS - WorldLeish
(Porte de Galinhas, Brasil)
2013/05 A new antigen for serological diagnosis of asymptomatic canine leishmaniasis: from discovery to field application FIFTH WORLD CONGRESS ON LEISHMANIASIS - WorldLeish 5
(Porto de Galinhas, Brasil)
2013/05 Leishmania-infected mature dendritic cells polarize CD4+ T cells towards a non-protective T-bet+ INF+ IL10+ phenotype . FIFTH WORLD CONGRESS ON LEISHMANIASIS - WorldLeish 5
(Porto de Galinhas, Brasil)
2013/04/18 New Immunotherapeutic Strategies VII Jornadas Ciências Biomedicina
CESPU (Porto)
2013/02/18 Leishmania, tales of a successful protozoan parasite: new insights on immune response subversion during infection International Seminars
Instituto de Salud Carlos III (Madrid, Espanha)
2012/05/24 Immunological response to leishmaniasis: from the murine model to human disease 2ªs Jornadas de Parasitologia
Escola Superior de Tecnologias de Saúde do Porto (Vila Nova de Gaia, Portugal)
2012/05 Leishmania-infected mature dendritic cells polarize CD4+ T cells towards a non-protective T-bet+ INF+ IL10+ phenotype EMBO|EMBL Symposium: New Perspectives on Immunity to Infection.
(Heidelberg, Alemanha)
2012/04/20 Estimating the post mortem interval through RNA and miRNA profiling. Congresso Crime do Século XXI
(Portugal)
2011/11 Infected but not Bystander Dendritic Cells polarize CD4+ T cells towards a non-protective T-bet+ INF-¿+ IL10+ phenotype XXXVII Annual Meeting of the Portuguese Society for Immunology "Portrait of the immune system: history and perspective
(Oeiras)
2011/10/26 Imunopatology of visceral leishmaniasis: current concepts and futures perspectives. Leishmanioses em Portugal no séx XXI. Leishmanioses em Portugal no Século XX
(Vila Real, Portugal)
2011/05/07 Recombinant Thiol Dependent Reductase 1 from Leishmania infantum induces protection against Visceral Leishmaniasis Second I3S Scientific Retreat IBMC/INEB/IPATIMUP together in science.
(Esposende, Portugal)
2010/03 Serological evaluation of experimentally infected dogs by LicTXNPX-ELISA and amastigote-flow cytometry Joint Expert Meeting between Working Groups 1 and 3 of the COST Action CM080
(Siena)
2009/09 PI3 kinase/AKT activation and NF-kappa B impairment: a strategy used by Leishmania parasites to impair DC function XXXV Annual Meeting of the Portuguese Society for Immunology
(Lisboa, Portugal)
2009/04 Leishmaniose: Novos métodos de prevenção, diagnóstico e tratamento.
Laboratório Nacional de Investigação Veterinária, (Porto, Portugal)
2009 Immunopathology of visceral leishmaniasis: progress and challenges 2nd IBMC scientific retreat
(Esposende, Portugal)
2008/10 Modulation of dendritic cells functions by Leishmania excreted/secreted proteins. XXXIV Annual Meeting of the Portuguese Society for Immunology
(Porto, Portugal)
2008/03 Immunological role of Leishmania secreted and nonsecreted antigens BSP Spring, Trypanosomiasis/Leishmaniasis and Malaria meeting
(Newcastle, Reino Unido)
2006/10 Attenuated SIR2-deficient Leishmania infantum as a vaccine candidate XXXII Annual Meeting of the Portuguese Society for Immunology
(Braga, Portugal)
2006/09 Altered virulence of L. infantum SIR2 single knockout-mutant: evaluation of its potential use as a vaccine candidate 16th European Congress of Immunology
(Paris, França)
2006/08 Leishmania cytosolic SIR2 deacetylase induces selective murine B-cell activation in vitro and in vivo 11th International Congress of Parasitology, ICOPA XI
(Glasgow, Reino Unido)
2006/05/08 Comparative study of the cytokine production in vitro and in vivo of three proteins involved in the trypanothione cascade II Simpósio Nacional de Citocinas
(Coibmra)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/01 - Atual Elucidation of the functional roles of lipid metabolism during canine leishmaniasis
Orientador de Marta Alexandra Senra Araújo
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022/09 - Atual The role of the effect of Lactobacillus on the phenotype induced by BCAA supplementation in Ulcerative Colitis
Orientador
Universidade de Coimbra, Portugal
2021/09 - Atual Malignant ascites microenvironment kinetics during ovarian cancer metastization: comprehension of therapeutic resistances
Coorientador de Diana Luísa de Almeida Nunes
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/01 - Atual Micronutrient sensing in human pathogenic parasites
Coorientador de Teresa Pires de Matos Alves Leão
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/01 - Atual Immunometabolic pathways underlying resistance or susceptibility to Mycobacterium tuberculosis infection
Coorientador de Consuelo Micheli
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/01 - Atual Immunometabolic Networks during dendritic cell-Leishmania interactions
Coorientador de Stephanie Maia Acuna
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01 - Atual Development of metabolically active immunomodulatory biomaterials (MAIBs) for the resolution of implant-related inflammation and promotion of tissue regeneration
Coorientador de Matias Cardoso
Universidade de Aveiro CICECO, Portugal
2019/01 - Atual Profiling of RNA degradation and biochemistry changes for estimation of postmortem interval. Influence of age and environmental temperature
Coorientador de Maria Bernardes André
Universidade do Porto Faculdade de Medicina, Portugal
2018/09 - Atual Therapeutic Potential of Branched-chain amino acids and succinate in Ulcerative Colitis
Orientador de Ana Isabel Mendes Frias
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/01 - Atual Reprogramming human arthritogenic T cells
Coorientador de Daniela Filipa Amaral Silva
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017/06 - Atual Immunometabolic Networks regulating visceral leishmaniasis
Orientador de Carolina Alves Ferreira
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/04 - Atual Dissecting the immunometabolic crosstalk of IL-17A/F-induced macrophage reprogramming during infection
Orientador de Inês Morais Mesquita
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/04 - Atual Evaluation of metabolic biomarkers in canine visceral leishmaniasis
Coorientador
Universidade Federal da Bahia Escola de Medicina Veterinária e Zootecnia, Brasil
2021/08/01 - 2023/01/10 Targeting glycolysis in Leishmania therapy
Orientador de Sónia Maria Barros Carvalho
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/01 - 2019/03/25 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis
Orientador de Joana Filipa Madureira Gaifem
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2019 Therapeutic potential of branched-chain amino acids and succinate in ulcerative colitis.
Orientador
 Biologia (Doutoramento)
Universidade do Minho, Portugal
2017/10 - 2018/10 Elucidating the impact of IL-17A/F in lung cancer
Coorientador de Nathalia Jacobsen Ferreira
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/06 - 2017/06 Impact of chronic inflammatory responses on the biology of monocytes/macrophages
Coorientador de Bruno Lima
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/12 - 2017/06 Macrophage-Leishmania nutrient flow: a fine tune that dictates the success of infection
Orientador de Diana Raquel Bento Moreira
Universidade do Porto Faculdade de Farmácia, Portugal
2015/09 - 2016/11 Plasmodium falciparum multidrug resistance protein 1 (PfMRP1) role in artemether-lumefantrine resistance
Coorientador de Miguel João Ferreira da Silva
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/02 - 2016/07 Immunopathological characterization of chemically induced colitis in mice from different animal houses
Orientador de Andreia Araújo
Laboratório Associado ICVS 3B's, Portugal
2016/02 - 2016/07 Orchestration of NAD biosynthetic pathways in the functional reprogramming of macrophage metabolism
Orientador de Joana Neves
Laboratório Associado ICVS 3B's, Portugal
2015/09 - 2016/06 Implication of amino acid metabolism in monocyte differentiation
Orientador de Ana Catarina Novais Belinha
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010/04 - 2014/12 Regulation of immunity to visceral Leishmania in a non-human primate model of infection
Coorientador de Vasco Manuel Teixeira Afonso Rodrigues
Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/03 - 2014/07 Bioenergetics evaluation of inflammatory macrophages
Orientador de Anabela Gonçalves
Laboratório Associado ICVS 3B's, Portugal
2013/09 - 2014/04 Estimating the post mortem interval by clinical chemistry
Orientador
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011/10 - 2012/09 Study of the cytokine profile during the acute phase of infection using murine models of resistance and susceptibility to leishmaniasis
Orientador de Jorge Augusto Pereira
Universidade do Porto Faculdade de Ciências, Portugal
2011/10 - 2012/09 Analysis of post-translational modifications in macrophages infected by Leishmania infantum
Orientador de Joana Requeijo
Universidade do Porto Faculdade de Ciências, Portugal
2011/10 - 2012/05 Role of microRNAs in the determination of post-mortem interval
Coorientador de Fernanda Patrícia Sampaio Silva
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010/12 - 2012/04 Study of IL-12 family of cytokines during visceral leishmaniasis
Orientador de Ana Luísa Robalo
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2010/10 - 2011/06 Modulatory activity of several defined culture mediums on Leishmania infantum virulence
Orientador de Cátia Sofia Ramos Silva
Universidade do Porto Faculdade de Ciências, Portugal
2010/10 - 2011/06 Relevance of axenic culture in Leishmania biology
Orientador de Ana Marina Amorim
Universidade do Porto Faculdade de Ciências, Portugal
2010/02 - 2010/10 Molecular mechanisms regulating apoptosis of antigen presenting cells during visceral leishmaniasis
Orientador de Ana Sofia Ramos
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2007/10 - 2008/12 Innate immune responses to the excreted/secreted antigens of Leishmania
Coorientador de Mariana Resende Silva
Universidade do Porto Faculdade de Ciências, Portugal
2005/10 - 2006/06 Immunological studies of a new Leishmania infantum excreted/secreted protein
Coorientador de Ana Sofia Cabral
Universidade do Porto Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022/04/20 - 2022/04/22 Annual Meeting Portuguese Society for Immunology, “At the crossroads of Human Immunology” (2022/04/20 - 2022/04/22)
Congresso (Membro da Comissão Organizadora)
 Sociedade Portuguesa de Imunologia, Portugal
2020/05/20 - 2020/05/22 XLVI Annual Meeting Portuguese Society for Immunology, “Current challenges and emerging topics in immunology” (2020/05/20 - 2020/05/22)
Congresso (Coorganizador)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/05/15 - 2019/05/17 XLV Annual Meeting Portuguese Society for Immunology, “Leaping forward translational immunology” (2019/05/15 - 2019/05/17)
Congresso (Membro da Comissão Organizadora)
 Universidade de Coimbra Faculdade de Medicina, Portugal
2015/10/25 - 2015/10/28 Portuguese Immunology Society Meeting (2015/10/25 - 2015/10/28)
Congresso (Membro da Comissão Organizadora)

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/01 The role of host lipid metabolism in the regulation of host antifungal immunity
Arguente principal
 Adrian Barnatiu (Mestrado)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2022/12 Células eucarióticas como fontes de biomateriais e materiais vivos
Arguente principal
 Matilde Rodrigues Lagarto (Mestrado)
Universidade de Aveiro, Portugal
2022/02 Evaluation of a mutation on 26S proteasome subunit of Plasmodium falciparum towards antimalarial resistance
Vogal
 Adriana Faria Gonçalves (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/10 Sex-based differences in T cell response
Arguente
 Juliana Gonçalves (Doutoramento)
Universidade Nova de Lisboa, Portugal
2021/09/24 Toxicological mechanism of tramadol and tapentadol: biomedical and forensic insights from in vivo studies
Vogal
 Maria Joana Almeida Rodrigues Barbosa (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2021/07 HLA epitope matching for allocation improvement in kidney transplantation,
Arguente
 Sandra Cristina Ribeiro Tafulo (Doutoramento)
2019/10/31 Disclosing the zinc acquisition and homeostatic machinery of Leishmania parasites
Arguente principal
 Teresa Pires de Matos Alves Leão (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2019/05 Alterações histopatológicas renais e oculares em cães em diferentes estadios clínicos de leishmaniose visceral naturalmente adquirida
Arguente principal
 Rosaclea Chagas dos Santos (Mestrado)
Universidade Federal da Bahia Escola de Medicina Veterinária e Zootecnia, Brasil
2018/06/15 Establishment of a three-dimensional in vitro model of air-blood barrier to assess the translocation of nanoparticles targeted to the lung
Arguente principal
 Ana Margarida Costa (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/06 Research into the toxicological mechanisms of tramadol and tapentadol: clinical and forensic aspects
Arguente principal
 Juliana da Conceição Fernandes de Faria (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018/04 In vitro and In vivo Studies of proatherogenic effects induced by end-products of cholesteryl esters oxidation
Arguente principal
 Neuza Luisa da Silva Domingues (Doutoramento)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017/12 Decoding the role of IL-10 in aging
Arguente principal
 Ana Catarina Pires Martins (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
2017/09/22 Leishmania infantum extracellular material and human invariant natural killer T cells: a functional study
Arguente principal
 Renata Belo da Costa (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/03 Canine Leishmaniasis: the role of hepatocytes and kupffer cells during Leishmania infantum infection
Arguente principal
 Maria Armanda Viana Rodrigues (Doutoramento)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/05/16 Phenotypic and Target-based Strategies for Drug discovery in Trypanosomes
Arguente principal
 Luís Gaspar (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/02 Adjuvant nanocarriers for Hepatitis B vaccine: Formulation design and mechanistic studies
Arguente principal
 Sandra Cristina Campos de Jesus (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/06 Impact of differential Toll-like receptor recognition of Mycobacterium tuberculosis strains on the adaptive imune system
Arguente principal
 Vânia Rita de Faria Cardoso (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011/10/11 Functional properties of human invariante natural killer T cells: from inflammation to tolerance
Vogal
 Lúcia de Fátima Moreira Teixeira (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2011/10 Determination of pyrethroid metabolites in urine
Arguente principal
 Isabel Cristina Meneses Monteiro da Silva (Mestrado)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011/09/29 Effects of cocaine, morphine and their combination in the liver mitochondrial bioenergetics
Arguente principal
 Lisbeth Elena Sousa e Silva (Mestrado)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2015/10/26 - 2015/10/28 From basic immunology to the latest clinical breakthroughs Portuguese Society of Immunology

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2013 - Atual Frontiers in Immunology (1664-3224) Frontiers Media SA

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2022 - Atual Fondo Sectorial de Salud 2022, Uruguay, Grant Reviewer
Avaliador
2019 - Atual ERC Starting Grant – 2019 - Remote Referee
Avaliador
 European Research Council
2019 - Atual Graduate Women in Science - Grant Reviewer
Avaliador
 Graduate Women in Science
2017 - Atual GID-IINFACTS 2017 Grants
Avaliador
 Cooperativa de Ensino Superior Politécnico e Universitário, Portugal Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde
2015 - Atual Grant Reviewer
Avaliador
 Israel Science Foundation, Israel Israel Science Foundation

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022 - Atual Immunometabolism: from basics to therapy, Advanced Course Immunometabolism: from basics to therapy (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/09 - Atual Invited Assistant Professor, Curricular Unit Immunology (Mestrado integrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018 - Atual Forensic Microbiology, Master in Forensic Sciences (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2014 - Atual Lecturer Fundamentals in Immunology (Curso de doutoramento (conclusão de unidades curriculares)) Laboratório Associado ICVS 3B's, Portugal
2008 - Atual Mecanismos de Imunização e Princípios Imunológicos de Vacinação Associação Nacional de Farmácias, Portugal
2016/03 - 2018/06 Invited Assistant Professor Doutoramento em Ciências Biológicas Aplicadas à Saúde (Doutoramento)
2005 - 2018 Lecturer GABBA program (graduated program in areas of applied and basic research), Immunology course (Doutoramento) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2012/10/01 - 2014/07/01 Invited Assistant Professor in Immunological Therapies Mestrado em Terapias Moleculares (Mestrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2012/10 - 2014/07 Invited Assistant Professor in Immunology and Parasitology Mestrado em Análises Clínicas (Mestrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011/10/01 - 2013/06/01 Invited Assistant Professor for Laboratory Methodologies Licenciatura em Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011/10 - 2013/06 Invited Assistant Professor, Curricular Unit Project (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2007 - 2009 Lecturer Experimental Biology and Biomedicine PhD program (Doutoramento) CNC.IBILI, Portugal
2007/10 - 2008/03 Invited Professor, Curricular Unit Immunology (Licenciatura) Universidade do Porto Faculdade de Farmácia, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2013/08/30 "Parasita da leishmaniose torna-nos cúmplices da sua infecção" Leishmaniasis parasite makes us accomplices of the infection News related to the paper published on JI. Resende M et al. 2013(highlighted in journal) We have unravelled the mechanism by which Leishmania-infected MHCIIhigh dendritic cells, in an IL-12 dependent manner, polarize CD4+ T cells toward a nonprotective T-bet+IFN-g+IL-10+ phenotype, which are associated with chronicity of infection. Público

Membro de associação

Nome da associação Tipo de participação
2018/01/09 - Atual European Society for Clinical Microbiology and Infectious Diseases Associate
2005/10/01 - Atual Portuguese Society for Immunology Member of General Assembly

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021 - Atual President of the Supervisory Board
Diretor
 Sociedade Portuguesa de Imunologia, Portugal
2019 - Atual Electoral Commission (by designation) in the context of the elections for ICVS Director)
Membro
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - Atual Governing Bodies of the Portuguese Society for Immunology, Secretary for the General Assembly
Membro
2014/07/01 - Atual Scientific Council
Membro
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Tutoria

Tópico Nome do aluno
2010 - 2014 Participation in “Ciência Viva no Laboratório" Several
Distinções

Prémio

2019 Innovation Projects in Traditional Food Products | FoodValorization and NewFood
2017 Best short presentation
Portuguese Society of Immunology., Portugal
2015 Best oral presentation
Portuguese Society of Immunology., Portugal
2004 Merit Award for graduation with 16/20 values
Universidade do Porto, Portugal