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Invited Assistant Professor, School of Medicine, University of Minho, Braga, Portugal. Graduation in biology, University of Porto, Portugal; PhD in neuro-oncology, IARC, France; Post-doc in cancer genomics, IPATIMUP / Portugal and VUMC / The Netherlands. Researcher productivity CNPq 1B. Scientific Director of the Research and Teaching Institute (IEP) and Coordinator of the Molecular Oncology Research Center (CPOM) of Barretos Cancer Hospital, Barretos, SP. Brazil.Extraordinary Professor, at Pan African Cancer Research Institute, University of Pretoria, South Africa.
Identificação

Identificação pessoal

Nome completo
RUI MANUEL VIEIRA REIS

Nomes de citação

  • Reis, RM
  • Reis, Rui Manuel

Identificadores de autor

Ciência ID
FB1F-DC2C-25D4
ORCID iD
0000-0002-9639-7940
Google Scholar ID
PLkVSekAAAAJ
Researcher Id
B-1744-2018
Scopus Author Id
8203632800

Moradas

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2002 - 2003
Concluído
 Health Sciences (Pós-doutoramento)
Especialização em Human and Medical Genetics
VU Medisch Centrum, Países Baixos

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1998 - 2002
Concluído
 Biologia Humana (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

International Agency for Research on Cancer, França
"Genetic alterations associated with development of human diffusely infiltrating astrocytomas" (TESE/DISSERTAÇÃO)
1991 - 1995
Concluído
 Biologia (Licenciatura)
Universidade do Porto, Portugal
"Involvement of Mycoplasma-like Organisms (MLO) as a causal agent for the Yellwos disease in Rubus plants" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2011 - Atual Investigador Coordenador (carreira) (Investigação) Hospital de Amor, Brasil
Centro de Pesquisa em Oncologia Molecular, Brasil
2010/05 - Atual Investigador principal (carreira) (Investigação) Hospital de Amor, Brasil
Centro de Pesquisa em Oncologia Molecular, Brasil
2003 - Atual Investigador principal (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2002 - 2003 Pós-doutorado (Investigação) VU Medisch Centrum, Países Baixos
2001 - 2003 Investigador (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020 - Atual Professor Associado (Docente Universitário) Universidade do Minho, Portugal
2010 - 2019 Professor Auxiliar Convidado (Docente Universitário) Universidade do Minho, Portugal
2003 - 2010 Professor Auxiliar (Docente Universitário) Universidade do Minho, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/09 - Atual Extraordinary Professor University of Pretoria, África do Sul
Pan African Cancer Research Institute, África do Sul
2019 - 2021/12/13 Pró-Reitor Hospital de Amor, Brasil

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - Atual Scientific Director- IEP Hospital de Amor, Brasil
2018 - 2021/12/01 Executive Director- IEP Hospital de Amor, Brasil
2015 - 2019 Coordinator of PIBIC Hospital de Amor, Brasil
1998 - 2001 PhD Student International Agency for Research on Cancer, França
1996 - 1997 Young Reasearch Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - Atual Embryonic T-box transcription factor Brachyury: Dissecting its role in prostate cancer biology and clinical application
PTDC/MED-ONC/31423/2017
Investigador responsável
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016 - Atual O conceito de moléculas-combinadas: uma nova abordagem no tratamento de câncer de pulmão avançado
Cancer research UK grants
Investigador
Cancer Research UK
Em curso
2014 - Atual Avaliação do câncer ocupacional e do potencial risco em trabalhadores rurais expostos a agentes carcinogênicos ambientais e ocupacionais na região de Barretos
Chamamento Publico n°20 – Estudos e Pesquisas Aplicadas em Vigilância em Saúde
Investigador
Ministério da Saúde
Em curso
2013 - Atual Estudo do papel biológico e terapêutico da Raf kinase inhibitor protein (RKIP) em GISTs e sua correlação com o fenótipo de instabilidade de microssatélites (MSI)
14/2013
Investigador responsável
Fundação de Amparo à Pesquisa do Estado de São Paulo
Em curso
2013 - Atual Estudo funcional da modulação dos miRNAs, miR-451 e miR-720, em linhagens celulares de tumores humanos
12/23326-6
Investigador
Centro de Pesquisa em Oncologia Molecular, Brasil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Em curso
2010/01/01 - Atual Cell-intrinsic and microenvironmental signals intertwined: novel targets for therapeutic intervention in acute lymphoblastic leukemia?
info:eu-repo/grantAgreement/FCT/3599-PPCDT/104816/PT
Investigador
Instituto de Medicina Molecular, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
2010 - Atual Role of WNK2 as a tumours suppressor gene in malignant gliomas
PTDC/SAU-OBD/100079/2008
Investigador
Em curso
2006 - Atual Molecular Profile of Portuguese GISTs
NOVASTIS2006
Investigador
Novartis Farma SA
Em curso
2023/05/01 - 2025/05/01 PAPEL DA CD24, UMA PROTEÍNA DO “CHECKPOINT” IMUNOLÓGICO, NA BIOLOGIA E TERAPIA DE MEDULOBLASTOMAS
FROC_ICVS_2023
Principal Investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
2016 - 2019 PersonalizedNOS: New avenues for the development of personalized medical interventions for neurological, oncologic and surgical disorders
NORTE-01-0145-FEDER-000013
Investigador
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluído
2014 - 2016 BIOPLAT – Plataforma Brasileira para Estudos de Bioprospecção de compostos naturias com potencial anticâncer em fase pré-clínica
MCTI/FINEP/MS/SCTIE/DECIT-1302/13
Investigador responsável
Finep
Concluído
2013 - 2015 Creation of large animal models to test the concepts of no scar, no radiation exposure approaches for minimally invasive surgery in the oncological field
NORTE-07-0124-FEDER-000017
Investigador
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluído
2013 - 2015 Estudo do efeito antineoplásico de extratos e derivados de Euphorbia tirucalli em tumores cerebrais e células tronco tumorais cerebrais
MCTI/CNPq Nº 73/2013
Investigador responsável
Conselho Nacional de Desenvolvimento Científico e Tecnológico
2012 - 2015 Estudo pré-clinico dos potenciais compostos anti-neoplásicos AM10 e AM11
Amazônia Fitomedicamentos
Investigador responsável
Centro de Pesquisa em Oncologia Molecular, Brasil
 Amazônia Fitomedicamentos
2011/04/01 - 2014 The Transcriptome of the Oncogenic HOXA9 Homeoprotein in Human Glioblastoma: Characterization and Functional Significance
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/113795/PT
Investigador
Universidade do Minho Escola de Medicina, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
2011/02/01 - 2014 Identification of novel target genes in microsatellite unstable brain tumours
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/115513/PT
Investigador responsável
Universidade do Minho Escola de Medicina, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
2011 - 2014 Potential predictive biomarkers of anti-RTKs therapy response in gliomas: An “in vitro” and “in vivo” Study
PTDC/SAU-TOX/114549/2009
Investigador responsável
Universidade do Minho Escola de Medicina, Portugal
Concluído
2012 - 2013 Caracterização da instabilidade genômica em glioblastomas: identificação e elucidação de novas vias moleculares em tumores e culturas primárias
CNPq Nº 014/2011
Investigador responsável
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluído
2011 - 2013 Avaliação do papel de microRNAs diferencialmente expressos no controle de invasão e metástase do câncer de mama
10/16796-0
Investigador
Hospital do Câncer de Barretos. Fundação Pio XII (FP), Brasil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluído
2010 - 2012 Implantação do Centro de Pesquisa Translacional em Oncologia
CT-INFRA-02/2010
Investigador responsável
Centro de Pesquisa em Oncologia Molecular, Brasil
 Finep
Concluído
2007 - 2009 Study of Therapeutic Target c-KIT in Brain Tumours
Prof. Francisco Gentil 2006
Investigador
Pfizer Biofarmacêutica Sociedade Unipessoal Lda
Concluído
2004 - 2009 Study of Molecular Predictive Factors of Chemotherapy Response in High-Grade Gliomas
Novartis2004
Investigador
Novartis Farma SA
Concluído
2003 - 2009 Analysis of Receptor Tyrosine Kinases in Uterine Cervix Cancer
Scheringh-Plough Grants
Investigador
Scheringh-Plough
Concluído
2002/12/01 - 2004 Application of microarray CGH for the study of chromosomal instability at different stages of gastric carcinogenesis
info:eu-repo/grantAgreement/FCT/POCI/41179/PT
Bolseiro de Pós-Doutoramento
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Lorena Vázquez-Iglesias; Giovanna Maria Stanfoca Casagrande; Daniel García-Lojo; Letícia Ferro Leal; Tien Anh Ngo; Jorge Pérez-Juste; Rui Manuel Reis; Krishna Kant; Isabel Pastoriza-Santos. "SERS sensing for cancer biomarker: Approaches and directions". Bioactive Materials (2024): https://doi.org/10.1016/j.bioactmat.2023.12.018.
    10.1016/j.bioactmat.2023.12.018
  2. Perdomo, Sandra; Abedi-Ardekani, Behnoush; de Carvalho, Ana Carolina; Ferreiro-Iglesias, Aida; Gaborieau, Valérie; Cattiaux, Thomas; Renard, Hélène; et al. "The Mutographs biorepository: A unique genomic resource to study cancer around the world". Cell Genomics (2024): 100500. http://dx.doi.org/10.1016/j.xgen.2024.100500.
    10.1016/j.xgen.2024.100500
  3. Pedro De Marchi; Leticia Ferro Leal; Luciane Sussuchi da Silva; Rodrigo de Oliveira Cavagna; Flavio Augusto Ferreira da Silva; Vinicius Duval da Silva; Eduardo CA da Silva; et al. "Gene expression profiles (GEPs) of immuno-oncologic pathways as predictors of response to checkpoint inhibitors in advanced NSCLC". Translational Oncology (2024): https://doi.org/10.1016/j.tranon.2023.101818.
    10.1016/j.tranon.2023.101818
  4. Lidia Maria Rebolho Batista Arantes; Renato José Silva-Oliveira; Ana Carolina de Carvalho; Matias Eliseo Melendez; Bruna Pereira Sorroche; Renan de Jesus Teixeira; Katiane Tostes; et al. "Unveiling the role of MGMT and DAPK hypermethylation in response to anti-EGFR agents: Molecular insights for advancing HNSCC treatment". Head & Neck (2023): https://doi.org/10.1002/hed.27602.
    10.1002/hed.27602
  5. Cíntia Regina Niederauer Ramos; Renato José Silva Oliveira; Marcela Nunes Rosa; Ariane Stéfani Pereira; Renata Barbosa Vahia de Abreu; Andre van Helvoort Lengert; Rui Manuel Reis; et al. "RAD50 Deficient in a Breast Cancer Model Predicts Sensitivity to PARP Inhibitors". Current Cancer Drug Targets (2023): https://doi.org/10.2174/1568009623666230418101511.
    10.2174/1568009623666230418101511
  6. Wesley Wang; Zeynep Temerit Kumm; Cindy Ho; Ideli Zanesco-Fontes; Gustavo Texiera; Rui Manuel Reis; Horacio Martinetto; et al. "Unsupervised machine learning models reveal predictive clinical markers of glioblastoma patient survival using white blood cell counts prior to initiating chemoradiation". Neuro-Oncology Advances (2023): https://doi.org/10.1093/noajnl/vdad140.
    10.1093/noajnl/vdad140
  7. de Oliveira C; Martins SFF; Gonçalves PG; Limone GA; Longatto-Filho A; Reis RM; Bidinotto LT. "Low EGFL7 expression is associated with high lymph node spread and invasion of lymphatic vessels in colorectal cancer.". Scientific reports (2023): http://europepmc.org/abstract/med/37957249.
    10.1038/s41598-023-47132-6
  8. Paula Rohr; Isabela Campanelli dos Santos; André van Helvoort Lengert; Marcos Alves de Lima; Rui Manuel Reis; Fernando Barbosa, Jr; Henrique Cesar Santejo Silveira. "Absolute telomere length in peripheral blood lymphocytes of workers exposed to construction environment". International Journal of Environmental Health Research (2023): https://doi.org/10.1080/09603123.2022.2066069.
    10.1080/09603123.2022.2066069
  9. Campanella NC; Gomes INF; Alves ALV; Leal LF; Evangelista AF; Rosa MN; Melendez ME; et al. "Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis.". Cancer cell international (2023): http://europepmc.org/abstract/med/37907993.
    10.1186/s12935-023-03102-6
  10. Oliveira AGS; Rocha MA; de Azevedo LS; Coelho ATM; Chagas RCR; Santos HB; Thomé RG; et al. "Tapirira guianensis is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in vivo.". Planta medica (2023): http://europepmc.org/abstract/med/37832581.
    10.1055/a-2181-2569
  11. Klein MO; Francisco LFV; Gomes INF; Serrano SV; Reis RM; Silveira HCS. "Hazard assessment of antineoplastic drugs and metabolites using cytotoxicity and genotoxicity assays.". Mutation research. Genetic toxicology and environmental mutagenesis (2023): http://europepmc.org/abstract/med/37973299.
    10.1016/j.mrgentox.2023.503704
  12. Moreno DA; Bonatelli M; Antoniazzi AP; de Paula FE; Leal LF; Garcia FAO; de Paula AE; et al. "High frequency of WNT-activated medulloblastomas with CTNNB1 wild type suggests a higher proportion of hereditary cases in a Latin-Iberian population.". Frontiers in oncology (2023): http://europepmc.org/abstract/med/37746264.
    10.3389/fonc.2023.1237170
  13. Fares AF; Li Y; Jiang M; Brown MC; Lam ACL; Aggarwal R; Schmid S; et al. "Association between duration of smoking abstinence before non-small-cell lung cancer diagnosis and survival: a retrospective, pooled analysis of cohort studies.". The Lancet. Public health (2023): http://europepmc.org/abstract/med/37633678.
    10.1016/s2468-2667(23)00131-7
  14. Santos FA; Reis RM; Barroti LC; Pereira AAL; Matsushita MM; de Carvalho AC; Datorre JG; Berardinelli GN; Araujo RLC. "Overall Survival, BRAF, RAS, and MSI Status in Patients Who Underwent Cetuximab After Refractory Chemotherapy for Metastatic Colorectal Cancer.". Journal of gastrointestinal cancer (2023): http://europepmc.org/abstract/med/37608030.
    10.1007/s12029-023-00964-x
  15. Adhara Brandão Lima; Mariana Bisarro dos Reis; Marcus Matsushita; Monise Tadin dos Reis; Marco Antônio de Oliveira; Rui Manuel Reis; Denise Peixoto Guimarães. "Combined SEPT9 and BMP3 methylation in plasma for colorectal cancer early detection and screening in a Brazilian population". Cancer Medicine (2023): https://doi.org/10.1002/cam4.6224.
    10.1002/cam4.6224
  16. Katiane Tostes; Aléxia Polo Siqueira; Rui Manuel Reis; Leticia Ferro Leal; Lidia Maria Rebolho Batista Arantes. "Biomarkers for Immune Checkpoint Inhibitor Response in NSCLC: Current Developments and Applicability". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241511887.
    10.3390/ijms241511887
  17. Fabiana L. Vazquez; Henrique C. S. Silveira; Ubirani B. Otero; Thais T. Hosokawa; José Humberto T. G. Fregnani; Adhemar Longatto-Filho; Rui M. Reis. "The Usefulness of an Online Simplified Screening Questionnaire (SSQ) in Identifying Work-Related Cancers". Healthcare (2023): https://doi.org/10.3390/healthcare11111563.
    10.3390/healthcare11111563
  18. Esther Clavero; Jose Manuel Sánchez Maldonado; Angelica Macauda; Rob Ter Horst; Sampaio-Marques, B.; Artur Jurczyszyn; Alyssa Clay-Gilmour; et al. "Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/10/8500.
    10.3390/ijms24108500
  19. Andreas Untergasser; Jan Hellemans; Michael W. Pfaffl; Jan M. Ruijter; Maurice J. B. van den Hoff; Mihnea P. Dragomir; Douglas Adamoski; et al. "Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action". Molecular Oncology (2023): https://doi.org/10.1002/1878-0261.13418.
    10.1002/1878-0261.13418
  20. Lorena R. Sousa; Ana Gabriela S. Oliveira; Antônio Arantes; João Gabriel M. Junqueira; Gerso P. Alexandre; Vanessa G. P. Severino; Rui Manuel Reis; Bonglee Kim; Rosy I. M. A. Ribeiro. "Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro". Molecules (2023): https://doi.org/10.3390/molecules28093809.
    10.3390/molecules28093809
  21. Causin RL; Van Helvoort Lengert A; Gomes INF; De Freitas AJA; Rosa MN; Dos Reis R; Reis RM; Marques MMC. "MicroRNA-130a-3p inhibition suppresses cervical cancer cell progression.". Oncology reports (2023): http://europepmc.org/abstract/med/37052265.
    10.3892/or.2023.8546
  22. Cavagna RO; Pinto IA; Escremim de Paula F; Berardinelli GN; Sant'Anna D; Santana I; Da Silva VD; et al. "Disruptive and truncating TP53 mutations are associated with African-ancestry and worse prognosis in Brazilian patients with lung adenocarcinoma.". Pathobiology : journal of immunopathology, molecular and cellular biology (2023): http://europepmc.org/abstract/med/37031678.
    10.1159/000530587
  23. René Aloisio da Costa Vieira; Débora Sant'Anna; Ana Carolina Laus; Carlos Eduardo Bacchi; René Julias Costa Silva; Idam de Oliveira-Junior; Vinicius Duval da Silva; Rui Pereira; Rui Manuel Reis. "Genetic ancestry of 1.127 Brazilian breast cancer patients and its correlation with molecular subtype and geographic region". Clinical Breast Cancer (2023): https://doi.org/10.1016/j.clbc.2023.04.001.
    10.1016/j.clbc.2023.04.001
  24. Causin RL; Sussuchi da Silva L; Leal LF; Possati-Resende JC; Evangelista AF; Matsushita GM; Scapulatempo-Neto C; Tavares Guerreiro Fregnani JH; Reis RM. "The digital expression profile of BMP7, CDKN2C, HIST1H3G, and PKMYT1 genes improves high-grade cervical lesion detection in liquid-based cytology.". Cancer cytopathology (2023): http://europepmc.org/abstract/med/37069588.
    10.1002/cncy.22704
  25. Zantut-Wittmann DE; Barreto IS; Laus AC; Moreno DA; Moma CA; Maia FFR; Assumpção LVMD; Reis RM. "PD-L1 and MCL-1 markers and the relationship with prognostic characteristics of differentiated thyroid carcinoma.". Molecular and cellular endocrinology (2023): http://europepmc.org/abstract/med/37072108.
    10.1016/j.mce.2023.111931
  26. Cabral ERM; Pacanhella MF; Lengert AVH; Dos Reis MB; Leal LF; de Lima MA; da Silva ALV; et al. "Somatic mutation detection and KRAS amplification in testicular germ cell tumors.". Frontiers in oncology (2023): http://europepmc.org/abstract/med/37007070.
    10.3389/fonc.2023.1133363
  27. Zantut-Wittmann DE; Laus AC; Moreno DA; Barreto IS; Moma CA; Maia F; Etchebehere E; Assumpção L; Reis RM. "Extremely aggressive course in a poorly differentiated thyroid carcinoma presenting a double mutation of the TERT promoter.". The American journal of the medical sciences (2023): http://europepmc.org/abstract/med/36972734.
    10.1016/j.amjms.2023.03.019
  28. Marques RF; Moreno DA; da Silva L; Leal LF; de Paula FE; Santana I; Teixeira G; et al. "Digital expression profile of immune checkpoint genes in medulloblastomas identifies CD24 and CD276 as putative immunotherapy targets.". Frontiers in immunology (2023): https://doi.org/10.3389/fimmu.2023.1062856.
    10.3389/fimmu.2023.1062856
  29. Silva VAO; Marcela N. Rosa; Izabela Faria; Vital, PS; Ana Laura Vieira Alves; Adriane Evangelista; Giovanna B. Longato; et al. "Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines". Molecules (2023): https://www.mdpi.com/1420-3049/28/3/1394.
    10.3390/molecules28031394
  30. Ferreira NN; Miranda RR; Moreno NS; Pincela Lins PM; Leite CM; Leite AET; Machado TR; et al. "Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructures for cancer therapy.". Frontiers in bioengineering and biotechnology (2023): http://europepmc.org/abstract/med/36815878.
    10.3389/fbioe.2023.1120179
  31. Garcia FAO; Evangelista AF; Mançano BM; Moreno DA; Berardinelli GN; de Paula FE; Antoniazzi AP; et al. "Genomic profile of two Brazilian choroid plexus tumors by whole-exome sequencing.". Cold Spring Harbor molecular case studies (2023): http://europepmc.org/abstract/med/36963804.
    10.1101/mcs.a006245
  32. Giovanna Maria Stanfoca Casagrande; Marcela de Oliveira Silva; Rui Manuel Reis; Letícia Ferro Leal. "Liquid Biopsy for Lung Cancer: Up-to-Date and Perspectives for Screening Programs". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032505.
    10.3390/ijms24032505
  33. René Aloisio da Costa Vieira; Débora Sant'Anna; Ana Carolina Laus; Rui Manuel Reis. "Ancestry and self-reported race in Brazilian breast cancer women". Revista da Associação Médica Brasileira (2023): https://doi.org/10.1590/1806-9282.20230767.
    10.1590/1806-9282.20230767
  34. Moreno DA; da Silva LS; Gomes I; Leal LF; Berardinelli GN; Gonçalves GM; Pereira CA; et al. "Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients' survival.". Therapeutic advances in medical oncology (2022): http://europepmc.org/abstract/med/36579028.
    10.1177/17588359221127678
  35. Teixeira SA; Luzzi MC; Martin ACBM; Duarte TT; Leal MO; Teixeira GR; Reis MT; et al. "The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models.". Veterinary sciences (2022): http://europepmc.org/abstract/med/36423085.
    10.3390/vetsci9110636
  36. Gonçalves PG; Reis RM; Bidinotto LT. "Significance of Chr9p22.1-p21.3 Deletion in Cancer Development: A Pan-cancer In Silico Analysis.". Anticancer research (2022): http://europepmc.org/abstract/med/36288884.
    10.21873/anticanres.16036
  37. García-Pardo M; Chang A; Schmid S; Dong M; Brown MC; Christiani D; Tindel HA; et al. "Respiratory and cardiometabolic comorbidities and Stage I-III non-small cell lung cancer (NSCLC) survival: A pooled analysis from the International Lung Cancer Consortium (ILCCO).". Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2022): http://europepmc.org/abstract/med/36396063.
    10.1016/j.jtho.2022.10.020
  38. Jéssika Cristina Chagas Lesbon; Taismara Kustro Garnica; Pedro Luiz Porfírio Xavier; Arina Lázaro Rochetti; Rui Manuel Reis; Susanne Müller; Heidge Fukumasu. "A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candidates". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231911911.
    10.3390/ijms231911911
  39. de Oliveira Cavagna R; Zaniolo BG; de Paula FE; Berardinelli GN; Santana I; da Silva ECA; Dias JM; et al. "ERBB2 exon 20 insertions are rare in Brazilian non-small cell lung cancer.". Thoracic cancer (2022): http://europepmc.org/abstract/med/36251951.
    10.1111/1759-7714.14605
  40. Alves Pinto I; de Oliveira Cavagna R; Virginio da Silva AL; Dias JM; Santana IV; Souza LC; Ferreira da Silva FA; Biazotto Fernandes MF; Leal LF. "EGFR Mutations and PD-L1 Expression in Early-Stage Non-Small Cell Lung Cancer: A Real-World Data From a Single Center in Brazil.". The oncologist (2022): http://europepmc.org/abstract/med/36099421.
    10.1093/oncolo/oyac167
  41. Wellington dos Santos; Edilene Santos de Andrade; Felipe Antonio de Oliveira Garcia; Natália Campacci; Cristina da Silva Sábato; Matias Eliseo Melendez; Rui Manuel Reis; Henrique de Campos Reis Galvão; Edenir Inez Palmero. "Whole-Exome Sequencing Identifies Pathogenic Germline Variants in Patients with Lynch-Like Syndrome". Cancers (2022): https://doi.org/10.3390/cancers14174233.
    10.3390/cancers14174233
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  385. Reis-Filho, J. S.; Pinheiro, C.; Lambros, M. B.; Milanezi, F.; Carvalho, S.; Savage, K.; Simpson, P. T.; et al. "EGFR amplification and lack of activating mutations in metaplastic breast carcinomas.". J Pathol 209 4 (2006): 445-53.
    10.1002/path.2004
  386. Sambade, C.; Berglund, M.; Lagercrantz, S.; Sällström, J.; Reis, R. M.; Enblad, G.; Glimelius, B.; Sundström, C.. "U-2940, a human B-cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma.". Int J Cancer 118 3 (2006): 555-63.
    10.1002/ijc.21417
  387. Reis, R.M.; Reis-Filho, J.S.; Filho, A.L.; Tomarev, S.; Silva, P.; Lopes, J.M.; Reis, R. M.; et al. "Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors". Pathology Research and Practice 201 12 (2005): 771-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-30444456045&partnerID=MN8TOARS.
    10.1016/j.prp.2005.08.010
  388. Carvalho, I.; Milanezi, F.; Martins, A.; Reis, R. M.; Schmitt, F.; Reis, R.M.. "Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression.". Breast Cancer Res 7 5 (2005): R788-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644873490&partnerID=MN8TOARS.
    bcr1304 [pii]10.1186/bcr1304
  389. Basto, D.; Trovisco, V.; Lopes, J. M.; Martins, A.; Pardal, F.; Soares, P.; Reis, R. M.. "Mutation analysis of B-RAF gene in human gliomas.". Acta Neuropathol 109 2 (2005): 207-10.
    10.1007/s00401-004-0936-x
  390. Reis, R.M.; Martins, A.; Ribeiro, S.A.; Basto, D.; Longatto-Filho, A.; Schmitt, F.C.; Lopes, J.M.. "Molecular characterization of PDGFR-a/PDGF-A and c-KIT/SCF in gliosarcomas". Cellular Oncology 27 5-6 (2005): 319-326. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244460120&partnerID=MN8TOARS.
  391. REIS, RUI; Lopes, José Manuel. "Genetic alterations of adult and paediatric astrocytic tumours". Revista de Neurología 38 (2004): 8-15.
    Publicado
  392. Reis, R.M.; Nakamura, M.; Masuoka, J.; Watanabe, T.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas". Acta Neuropathologica 101 4 (2001): 297-304. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035032855&partnerID=MN8TOARS.
  393. Reis, R.M.; Herva, R.; Brandner, S.; Koivukangas, J.; Mironov, N.; Bär, W.; Kleihues, P.; Ohgaki, H.. "Second primary glioblastoma". Journal of Neuropathology and Experimental Neurology 60 2 (2001): 208-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035111348&partnerID=MN8TOARS.
  394. Reis, R.M.; Hara, A.; Kleihues, P.; Ohgaki, H.. "Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas". Acta Neuropathologica 102 5 (2001): 422-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034774966&partnerID=MN8TOARS.
  395. Reis, R.M.; Nakamura, M.; Masuoka, J.; Watanabe, T.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Erratum: Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas (Acta Neuropathologica (2001) vol. 101 (297-304))". Acta Neuropathologica 101 6 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034914191&partnerID=MN8TOARS.
  396. Rui M. Reis; Dilek Könü-Lebleblicioglu; Jose Manuel Lopes; Paul Kleihues; Hiroko Ohgaki. "Genetic Profile of Gliosarcomas". The American Journal of Pathology 156 2 (2000): 425-432. http://dx.doi.org/10.1016/s0002-9440(10)64746-3.
    10.1016/s0002-9440(10)64746-3
  397. Fujisawa, H.; Reis, R.M.; Nakamura, M.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas". Laboratory Investigation 80 1 (2000): 65-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033968345&partnerID=MN8TOARS.
  398. Alves, C.; Silva, F.; Gusmão, L.; Seruca, R.; Soares, P.; Reis, R. M.; Amorim, A.. "Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: characterisation in a normal population and in thyroid and gastric tumours.". Eur J Hum Genet 8 7 (2000): 540-4.
    10.1038/sj.ejhg.5200486
  399. Huang, H.; Reis, R.; Yonekawa, Y.; Lopes, J.M.; Kleihues, P.; Ohgaki, H.. "Identification in human brain tumors of DNA sequences specific for SV40 large T antigen". Brain Pathology 9 1 (1999): 33-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032958518&partnerID=MN8TOARS.
  400. Fujisawa, H.; Kurrer, M.; Reis, R. M.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.". Am J Pathol 155 2 (1999): 387-94.
    S0002-9440(10)65135-8 [pii]10.1016/S0002-9440(10)65135-8
Capítulo de livro
  1. Cardoso-Carneiro, Diana; Raquel-Cunha, Ana; Pinheiro, Joana; Gabriela-Freitas, Maria; Fontão, Patrícia; Reis, Rui M.; Martinho, Olga; et al. "Implications of RKIP protein in cancer prognosis and therapy response: A literature update". In Prognostic and Therapeutic Applications of RKIP in Cancer, 389-414. Elsevier, 2020.
    Publicado • 10.1016/b978-0-12-819612-0.00020-1
  2. Santana, IV; da Silva, V; REIS, RUI. "Classificação Molecular do Câncer de Mama". In Câncer de Mama: Uma Filosofia de Tratamento - Breast Unit Barretos, 204-209. Thieme Revinter, 2018.
    Publicado
  3. De Mello, Ramon Andrade; Luis, Michael; Araújo, António; Reis, Rui Manuel; Hespanhol, Venceslau. "The Role of Angiogenesis in Non-small Cell Lung Cancer Tumor Behavior". In Biochemical Basis and Therapeutic Implications of Angiogenesis, 217-239. Springer International Publishing, 2017.
    Publicado • 10.1007/978-3-319-61115-0_10
  4. Fernandes, Ana C.; Caeiro, Cláudia; Miranda-Gonçalves, Vera; Cury, Fernanda; Damasceno, Margarida; REIS, RUI; Martinho, Olga. "Bevacizumab for Glioblastoma Treatment: Reviewing Biological and Clinical Hypothesis for its Success and Failures". In Anti-Angiogenesis Drug Discovery and Development, 175-226. Bentham Science Publishers, 2016.
    Publicado • 10.2174/9781681081557116030007
  5. Gonçalves, Vera Miranda; Baltazar, Fátima; Reis, Rui Manuel. "Brain Tumor Metabolism — Unraveling Its Role in Finding New Therapeutic Targets". In Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor, 83. InTech, 2015.
    Publicado • 10.5772/59606
  6. Paixao Becker, Aline; Scapulatempo-Neto, Cristovam; Neder, Luciano; Chimelli, Leila; Reis, Rui M.. "Pilocytic Astrocytoma: Anatomic, Pathological and Molecular Aspects". In Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors, 127-143. InTech, 2013.
    Publicado • 10.5772/53956
  7. de Mello, Ramon Andrade; Luis, Michael; Araújo, António; Reis, Rui Manuel; Hespanhol, Venceslau. "Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small-Cell Lung Cancer Tumor Behavior: Implications in Risk Assessment and Clinical Outcome". In Biochemical Basis and Therapeutic Implications of Angiogenesis, 381-403. Springer, New York, 2013.
    Publicado • 10.1007/978-1-4614-5857-9_20
  8. Viana-Pereira, Marta; Jones, Chris; Reis, Rui Manuel. "Pediatric High-Grade Glioma: Role of Microsatellite Instability". In Pediatric Cancer: Diagnosis, Therapy and Prognosis, 205-210. Springer, Dordrecht, 2012.
    Publicado • 10.1007/978-94-007-4528-5_22
  9. Nogueira-de-Souza, Naiara Correa; Almeida, José Reinaldo; Serrano, Sérgio V.; REIS, RUI. "BRAF in glioblastomas: Clinical implications". In Glioblastoma: Risk Factors, Diagnosis and Treatment Options, 227-240. Nova Science Publishers, Inc., 2012.
    Publicado
  10. Becker, AP; Caravina, G; Clara, C; REIS, RUI. "The Role of Immunohistochemistry in the Diagnostic and Prognostic of Glioblastoma Patients". In Glioblastoma: Risk Factors, Diagnosis and Treatment Options, 173-199. Nova Science Publishers, 2012.
    Publicado
  11. Martinho, Olga; Reis, Rui Manuel. "Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA)". In Tumors of the Central Nervous System, 109-118. Springer, Dordrecht, 2011.
    Publicado • 10.1007/978-94-007-0344-5_12
  12. Viana-Pereira, Marta; Jones, Chris; Reis, Rui M.. "Genetic Instability in Paediatric and Adult Brain Tumours". In Molecular Targets of CNS Tumors, 19. InTech, 2011.
    Publicado • 10.5772/19571
  13. Ohgaki, H.; Biernat, W.; REIS, RUI; Hegi, M.; Kleihues, P.. "Gliosarcoma". In WHO Classification of Tumours. Pathology and Genetics of Tumours of the Nervous System, 42-44. IARC Press, 2000.
    Publicado
Pré-impressão
  1. Junior JNA; Preto DD; Lazarini MEZN; de Lima MA; Bonatelli M; Berardinelli GN; Silva VDd; et al. "PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site". 2023. http://europepmc.org/abstract/PPR/PPR765319.
    10.21203/rs.3.rs-3369856/v1
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/07/01 - Atual RKIP-regulated miRNAs in Gastrointestinal Stromal Tumor (GIST
Orientador
 Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - Atual Identification of the gene expression profile in metastatic renal cell carcinomas treated with sunitinib and its predictive response value
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2019 - Atual Design and Implementation of an Integrated Lung Cancer Screening and Prevention Program using Mobile Computed Tomography
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2019 - Atual Methylation analysis of tumor suppressor genes SEPT9, NDRG4 and BMP3 in the plasma of participants in the colorectal cancer screening program at the Barretos Cancer Hospital
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2019 - Atual Development and implementation of a control and process management system for the medical and multiprofessional home secretary
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2019 - Atual RKIP protein as a novel predictor of EGFR targeted therapy response in lung cancer
Coorientador
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Hospital de Amor, Brasil
2018 - Atual Development of a gene expression panel to predict lymph node involvement in patients with non-small cell lung cancer
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - Atual Applicability of a nomogram including clinical and molecular variables in the stratification of risk groups in pediatric medulloblastoma
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - Atual Identification of predictive biomarkers of response to treatment with temozolomide in glioblastoma
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - Atual Analysis of somatic changes in the number of DNA copies of renal clear cell carcinoma
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - Atual RKIP protein as metastatic and therapeutic biomarker in cervical cancer
Coorientador
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Hospital de Amor, Brasil
2018 - Atual Molecular Profile Identification Associated With Response To Treatment With Immunological Checkpoints Inhibitors In Patients With Non-Small Cell Lung Cancer
Orientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2017 - Atual Study Of Biomarkers Response To Cetuximabe And Perspectives For The Use Of Anti-Egfr Combi-Molecules In Solid Tumors
Orientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2017 - Atual Recommended Low Risk Endometric Adenocarcinoma. Is There A Predictive Genetic Signature For This Population?
Coorientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2017 - Atual Evaluation Of Braf Mutation As A Predictive Factor Of Benefit To Chemotherapy In Patients With Metastatic Or Locally Advanced Irresectable Cancer Treated With Cetuximab In The Barretos Cancer Hospital
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2015 - Atual Molecular characterization of MTAP (Methylthioadenosine phosphorylase) and evaluation of its therapeutic potential in gliomas
Orientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2022/01/02 - 2033/12/30 Characterization and biological impact of medulloblastomas immune profile
Orientador
 Oncology (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/12/01 - 2026/12/31 Risco Genético de Cancro Colorretal Esporádico na Região do Minho: Um Estudo GWAS (Genome-Wide Association Study)
Orientador
 Oncology (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - 2023 ValidaçãO de biomarcadores preditivos da resposta à temozolomida em glioblastomas.
Orientador de Ideli Zanesco Fontes Baptista
Hospital de Amor, Brasil
2020 - 2023 Caracterização do efeito biológico do composto semissintético derivado de Euphorbia tirucalli in vitro e in vivo, a partir do estabelecimento de um modelo xenográfico derivado de pacientes com câncer de esôfago.
Orientador de Ana Laura Vieira Alves
Hospital de Amor, Brasil
2020 - 2023 Avaliação da frequência e impacto clínico das laterações moleculares “drivers” em 1000 pacientes com c6ancer de pulmão de células não pequenas tratados no Hospital de Câncer de Barretos.
Orientador de Rodrigo de Oliveira Cavagna
Hospital de Amor, Brasil
2020 - 2022 Associação da instabilidade de microssatélites (MSI) e vírus Epstein-Barr (EBV) com a resposta patológica em pacientes com adenocarcinoma gástrico submetidos a quimioterapia perioperatória com Flofox e Flot.
Orientador de Diego Burgardt
Hospital de Amor, Brasil
2020 - 2022 Análise de Brotamento Tumoral como fator prognóstico em pacientes com carcinoma colorretal do Hospital de Câncer de Barretos.
Orientador de Monise Tadin Reis
Hospital de Amor, Brasil
2016 - 2020 In vitro and in vivo characterization of the antineoplastic potential of natural plant extracts and derivatives in commercial and primary cervical tumor lines
Orientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2018 - 2019 New Diagnostic Method for Detecting Alk / Ret / Ros1 Fusions in Patients with Lung Adenocarcinoma Without Mutations in Kras and Egfr Genes
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - 2019 Dissecting chemotherapy resistance in prostate cancer: interplay between RKIP and androgen stimulation
Coorientador
 Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2019 Characterization of the involvement of the WNK2 protein in autophagic and endocytic vesicular traffic in gliomas
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2017 - 2019 Evaluation of expression and prognostic potential of genes present in the chr9p22.1-p21.3 locus in gliomas
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2017 - 2019 Analysis of the frequency of BRAF gene mutations and association with clinicopathological characteristics of patients with lung adenocarcinoma for future direction of clinical management with target therapy
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2017 - 2019 Post-doc supervision of Nathalia Campanella (FAPESP Fellowship)
Orientador
Hospital de Amor, Brasil
2016 - 2019 Analysis of the hypermethylation profile of a panel of tumor suppressor genes in precursor lesions and colorectal cancer
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2016 - 2019 Mutational profile of an extensive panel of oncogenes and tumor suppressor genes in colorectal cancer and its precursor lesions
Coorientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2015 - 2019 Post-Doc Supervision of Olga Martinho (FCT Fellowship)
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018 Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma
Coorientador
 Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018 Post-doc supervision of Juliana Alves Uzuelli (FAPESP Fellowship)
Orientador
Hospital de Amor, Brasil
2017 - 2018 Evaluation of potential RKIP and SDHB biomarkers in gastrointestinal stromal tumors (GISTs)
Orientador
Hospital de Amor, Brasil
2016 - 2018 Genotypic frequency of the EGF + 61 A> G polymorphism and analysis of associated melanoma risk in a miscigenic population
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2016 - 2018 Detection of high-risk HPV DNA and analysis of the mutational status of the KRAS and PIK3Ca genes and the inflammatory cytokine panel in patients with esophageal cancer and chagasic megaesophagus with and without cancer
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2016 - 2018 Application of visual programming analysis methods to cervical cancer data from The Cancer Genome Atlas
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2011 - 2018 Post-Doc Supervision of Marta Viana Pereira (FCT Fellowship)
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2017 Epidemiological, clinical-pathological and therapeutic characterization and its correlation with the ethnic ancestry of Brazilian patients with colorectal cancer
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2015 - 2017 Evaluation Of Anti-Tumoral Partitioning Activity And Chlorophormal Fractions Of Miconia Chamissois naudin In Human Glioma Lines
Coorientador
 Biotechnology (Mestrado)
Universidade Federal de São João del-Rei, Brasil
2015 - 2017 Evaluation of the antineoplastic activity of enriched fractions of Annona coroacea Mart. in gynecological strains
Coorientador
 Biotechnology (Mestrado)
Universidade Federal de São João del-Rei, Brasil
2015 - 2017 Post-doc supervision of Carla Carolina Munari (CNPq Fellowship)
Orientador
Hospital de Amor, Brasil
2013 - 2017 Elucidation of the molecular and clinical impact of microsatellite instability in patients with sporadic colorectal carcinoma at the Barretos Cancer Hospital.
Orientador
 Oncolgy (Doutoramento)
Hospital de Amor, Brasil
2014 - 2016 Expression of the AXL tyrosine kinase receptor in patients with metastatic renal cell carcinoma treated with sunitinib and its association with clinical and pathological outcomes
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2014 - 2016 Characterization of the antineoplastic potential of natural compounds and their derivatives in commercial, primary and brain tumor stem cells
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2014 - 2016 Mutational Characterization of KRAS and BRAF Oncogenes and Analysis of MSI in Precursor Lesions of Colorectal Cancer
Coorientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2014 - 2016 Monocarboxylate Transporters in gliomas: regulation and therapeutic implications
Coorientador
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014 - 2016 Study of prognostic and therapeutic response biomarkers in gastrointestinal stromal tumors (GISTs)
Orientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2012 - 2016 Identification of new predictive biomarkers of the response to anti-EGFR therapy in solid tumors.
Orientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2011 - 2016 Learning from the embryo: Understanding early embryonic T gene – Brachyury – impact in human tumorigenesis
Orientador
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2015 Post-doc supervision of Giovanna Barbarini Longato (CNPq Fellowship)
Orientador
Hospital de Amor, Brasil
2014 - 2015 Study of Mutations of the HDI-1 Gene in Gliomas
Orientador
Hospital de Amor, Brasil
2014 - 2015 Potentiation studies of Eufol compost derived from the Euphorbia tirucalli plant encapsulated in zeolites as drug delivery systems for in vitro models of brain tumors
Orientador
Hospital de Amor, Brasil
2013 - 2015 Post-Doc Supervision of Renata Costa Camargo (CNPq fellowship)
Orientador
Hospital de Amor, Brasil
2012 - 2015 Assessment of the MAPK pathway in the oncogenesis of pilocytic astrocytomas
Orientador
 Oncology (Doutoramento)
Hospital de Amor, Brasil
2014 - 2014 Post-doc supervision of Rosana Antunes Silveira (CAPES Fellowship)
Orientador
Hospital de Amor, Brasil
2012 - 2014 Post-doc supervision of Viviane Silva (Amazônia Fitomedicamentos Fellowship)
Orientador
Hospital de Amor, Brasil
2010 - 2014 Head and Neck Squamous Cell Carcinoma: integrating genomic, epigenetic and transcriptomic data - from bench to clinical applications
Coorientador
 Health Sciences and Technology (Doutoramento)
Universidade de Coimbra, Portugal
2009 - 2014 Identification of intragenic copy number alterations and fusion genes in paediatric glioblastoma
Coorientador
 Human Biology (Doutoramento)
Universidade de Coimbra, Portugal
2011 - 2013 Study of the tumor suppressor gene, TP53, in squamous cell carcinoma of the esophagus associated with chagasic megaesophagus
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2011 - 2013 Cytogenetic and Molecular characterization of Primary Glioma Strains
Orientador
 Oncology (Mestrado)
Hospital de Amor, Brasil
2011 - 2013 Post-doc supervision of Lucas Tadeu Bidinotto (FAPESP Fellowship)
Orientador
Hospital de Amor, Brasil
2009 - 2013 Study of the Influence of Polymorphisms in the Angiogenesis Pathway in Lung Cancer
Coorientador
 Human Biology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2012 Role of WNK2 protein kinase as a suppressor gene for malignant gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011 - 2012 Potential predictive biomarkers of anti-RTKs therapy response in gliomas: An in vitro and in vivo Study
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2012 microRNAs in cancer: biological effects of microRNAs in colorectal cancer
Orientador
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2012 Role of monocarboxylate transporters in the metabolic remodeling of glioblastomas
Coorientador
 Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2012 Study of Biomarkers of Proliferation and Neovascularization: Clinical, Imagiological and Molecular Correlation
Coorientador
 Clinical Sciences (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2012 Exploitation of monocarboxylate transporters (MCTs) as potential therapeutic targets in brain tumours
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2011 Evaluation of inhibition of monocarboxylate transporters in gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2011 Post-doc supervision of Bruno Costa (FCT Fellowship)
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2011 RTKs and MAPK pathway alterations in solid tumors: dissecting prognostic and therapeutic biomarkers
Orientador
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2011 Development of Computational Tools for the Integrated Analysis of DNA Microarray Data with Applications in Cancer Research
Coorientador
 Bioinformatics (Doutoramento)
Universidade do Minho Departamento de Informática, Portugal
2007 - 2011 Study of New Potential Molecular Targets for Pediatric Brain Tumors Therapy
Orientador
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Study of SPINT2 methylation and correlation with MET tyrosine kinase receptor expression
Orientador
 Biochemistry (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Drug encapsulation in nanostructures: Application in tumor cell lines
Orientador
 Chemistry (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Influence of HOXA9 Expression in the Cellular Response to Chemotherapy
Orientador
 Biochemistry (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 HOXA9's role in the response of gliomas to temozolomide and radiotherapy
Orientador
 Medicine (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2010 Role of tumour suppressor gene RKIP in solid tumors
Orientador
 Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2010 Evaluation of Microsatellite Instability in Brain Tumors
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Analysis of the G-174C polymorphism in the IL-6 gene in breast cancer
Orientador
 Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Association of the T-1237C polymorphism in the Toll Like Receptor 9 (TLR9) gene with susceptibility to the development of breast cancer and gliomas
Orientador
 Medicine (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Is the plexin B1 gene mutated in prostate cancer?
Orientador
 Medicine (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Epigenetic and expression analysis of AP-2a in brain tumors
Orientador
 Medicine (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2009 Establishment and characterization of two in vivo models for gliomagenesis
Orientador
 Medical Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2009 Implementation of an integrative platform for gene expression data analysis
Coorientador
 Bioinformatics (Mestrado)
Universidade do Minho Departamento de Informática, Portugal
2008 - 2009 Association between EGF + 61 polymorphism and risk for breast cancer
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2008 Evaluation of RKIP expression in glioblastomas
Orientador
 Medicine (Curso de aperfeiçoamento / especialização)
Universidade do Minho Escola de Medicina, Portugal
2008 - 2008 Evaluation of the prognostic potential of the MGMT gene in glioblastomas at Hospital S.João
Orientador
 Medicine (Curso de aperfeiçoamento / especialização)
Universidade do Minho Escola de Medicina, Portugal
2008 - 2008 Methylation study of the AP2-alpha gene in medulloblastomas
Orientador
 Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2008 Role of MGMT and HOXA9 in the prognosis of glioblastomas
Orientador
 Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2008 Expression of tyrosine kinase receptors PDGFRa, KIT and VEGFR-2 in gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2008 TP53 mutations in Portuguese glioblastomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2008 Evaluation of KIT mutations in GISTs
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2008 Molecular Determinants of Glioma Risk and Patient Prognosis
Orientador
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2007 Analysis of TP53 mutations in gliomas
Orientador
 Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2007 Analysis of the potential of the liquid-based cytology medium for molecular studies
Orientador
 Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2007 Analysis of c-kit changes in human tumors
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2007 Optimization of PDGFRA mutations in gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2006 Study of EGFR mutations in bladder carcinomas
Orientador
 Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2006 Analysis of EGFR mutations in breast cancer
Orientador
 Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Analysis of molecular changes in solid tumors
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Molecular changes in glial tumors
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Influence of epigenetic changes in response to chemotherapy in patients with gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2005 Molecular Characterization of EGFRvIII and B-RAF Oncogenes in Gliomas
Orientador
 Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2005 Polymorphism analysis of TP53 (codon 72) in gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2003/02 - Atual Fundamentals of medical genetics. Health Sciences (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2003/02 - Atual Genetics Medicine (Mestrado integrado) Universidade do Minho Escola de Medicina, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2011 - Atual Member of the Post-graduation committee.
Membro
 Hospital de Amor, Brasil
Distinções

Prémio

2023 Best Translational Research Poster
A.C.Camargo Cancer Center, Brasil
2023 Best Poster Award
Associação Portuguesa de Neuro-Oncologia, Portugal
2022 Best Poster
XXIX Congresso de Pneumologia do Norte, Portugal
2021 Best Poster
XV Congresso da MutaGen-Brasil, Brasil
2021 Best oral presentation
Brazilian Breast Cancer Symposium, Brasil
2020 3rd Place, Oral Presentation
American Association for Cancer Research, Estados Unidos
2019 Best Oral Presentation
Sociedade Brasileira de Patologia, Brasil
2019 Best Poster
ACCamargo Cancer Center, Brasil
2019 Best Poster
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 Best Oral Presentation
Society for Neuro Oncology Latin America, Brasil
2017 Best Poster
2017 Awards SBP and EPOAHT
Sociedade Brasileira de Patologia, Brasil
2017 3rd place Prize for Best Work
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, Brasil
2017 Best Oral Presentation
Sociedade Brasileira de Patologia, Brasil
2016 50-for-50: Empowering future cancer research leaders
International Agency for Research on Cancer, França
2015 Best Poster in the field of "Mecanismos de ação de drogas"
Sociedade Brasileira de Bioquímica e Biologia Molecular, Brasil

International Union of Biochemistry and Molecular Biology, Canadá
2015 2nd place Prize for Best Oral Presentation
Hospital de Amor, Brasil
2015 Best Poster
Hospital de Amor, Brasil
2015 2nd place Prize for Best Poster
Hospital de Amor, Brasil
2015 Best article published in “Acta Urológica Portuguesa”
Sociedade Portuguesa de Neurologia, Portugal
2015 Best work of the session "Apresentação Oral / Temas Livres"
Sociedade Brasileira de Patologia, Brasil
2015 Best Poster in the field of "Bioquímica e Biologia Molecular dos Eucariotos Superiores"
Sociedade Brasileira de Bioquímica e Biologia Molecular, Brasil

International Union of Biochemistry and Molecular Biology, Canadá
2014 Award Newton Freire-Maia - in genetics and human evolution and medical genetics
2014 2nd place Prize for the Best Poster
2014 2nd place Prize for the Best Oral Presentation
Sociedade Portuguesa de Oncologia, Portugal
2014 Best Oral Presentation
Hospital de Amor, Brasil
2014 2nd place Prize for the Best Oral Presentation
Hospital de Amor, Brasil
2014 Best Poster
Hospital de Amor, Brasil
2013 Best Poster
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013 Best Oral Presentation
Hospital de Amor, Brasil
2013 Honor Mention
2012 Best Oral Presentation
2012 Travel Award
2012 “VII Prêmio Saúde Abril 2012”
2011 Best Poster in Translational Research
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2011 Merit Award
International Society of Oncology and Biomarkers, Reino Unido
2009 3rd place Prize for the Best Oral Presentation
2009 Best Poster
2009 2nd place Prize for the Best Oral Presentation in Oncology and Molecular Biology
Universidade do Porto Faculdade de Medicina, Portugal
2009 Best Poster in Oncology and Molecular Biology
Universidade do Porto Faculdade de Medicina, Portugal
2009 Best Oral Presentation
2009 Best Scientific Work
2007 1st Prize in Neurosciences
Universidade do Porto Faculdade de Medicina, Portugal
2006 1st Prize in Clinical Research
2006 1st Prize in Oncology
Universidade do Porto Faculdade de Medicina, Portugal
2006 1st Pfizer Prize in "Research in Oncology Diseases, Prof. Francisco Gentil"
2005 Best Poster
Sociedade Portuguesa de Oncologia, Portugal
1995 Highest classification in Biology at University of Porto
Fundação Engenheiro António de Almeida, Portugal