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Identificação

Identificação pessoal

Nome completo
João Duarte

Nomes de citação

  • Duarte, João
  • João Miguel das Neves Duarte
  • Duarte, JMN

Identificadores de autor

Ciência ID
F21C-47FC-9A5A
ORCID iD
0000-0001-5984-1574
Google Scholar ID
https://scholar.google.com/citations?user=d8xhLzYAAAAJ&hl=en
Researcher Id
H-4887-2012
Scopus Author Id
10144128400

Moradas

  • Solvegata 19, 22184, Lund, Lund, Suécia (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Formação
Grau Classificação
2004/09/01 - 2009/02/12
Concluído
 Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004/12/07
Concluído
 Bioquímica (Licenciatura)
Universidade de Lisboa, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/10/01 - Atual Investigador principal (carreira) (Investigação) Lunds universitet Medicinska fakulteten, Suécia
Diabetes and Brain Function lab, Suécia
2013/09/01 - 2017/09/30 Investigador (Investigação) École Polytechnique Fédérale de Lausanne, Suiça
2008/09/01 - 2013/09/01 Investigador (Investigação) Université de Lausanne Faculté de biologie et médecine, Suiça

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/09/01 - Atual Professor Associado (Docente Universitário) Lunds Universitet Institutionen för Experimentell Medicinsk Vetenskap, Suécia
2017/10/01 - 2020/08/31 Professor Auxiliar (Docente Universitário) Lunds Universitet Institutionen för Experimentell Medicinsk Vetenskap, Suécia

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2022 - Atual Coordinator (international partner) of the course “Advanced Topics on Brain Energy Metabolism”, Program of Biological Sciences and Biophysics Universidade Federal do Estado do Rio de Janeiro, Brasil
Lunds universitet Medicinska fakulteten, Suécia
(...)
2021/09/01 - Atual Examiner for course “The cell in its environment”, Biomedicine Bachelor program Lunds universitet Medicinska fakulteten, Suécia
Lunds universitet Medicinska fakulteten, Suécia
2020/09/01 - Atual Vice-coordenador Lund University Diabetes Centre, Suécia
2019/01/01 - Atual Mouse Behaviour Platform managing board member Lunds universitet Medicinska fakulteten, Suécia
Biomedical Centre (BMC) Mouse Behaviour Platform, Suécia
2019/01/01 - Atual Responsible teacher, “Scientific controversy and reasoning” in the Homeostasis course, Medicine program Lunds universitet Medicinska fakulteten, Suécia
Diabetes and Brain Function lab, Suécia
2019/01/01 - Atual Coordinator of the course Metabolic Diseases in the Biomedicine Master program Lunds universitet Medicinska fakulteten, Suécia
2018/01/01 - Atual Steering Group Member of the WCMM Regenerative Medicine Research School Wallenberg Centre for Molecular Medicine, Suécia
Lunds universitet Medicinska fakulteten, Suécia
(...)
2020/01/01 - 2022/12/31 Member of the Election Committee Lunds Universitet Institutionen för Experimentell Medicinsk Vetenskap, Suécia
Biomedical Centre (BMC) Mouse Behaviour Platform, Suécia
2019/06/01 - 2021/06/01 Coordinator of the WCMM Regenerative Medicine Research School Wallenberg Centre for Molecular Medicine, Suécia
Lunds universitet Medicinska fakulteten, Suécia
(...)
2019/01/01 - 2020/12/31 WCMM Communication Group member Lunds universitet Medicinska fakulteten, Suécia
Wallenberg Centre for Molecular Medicine, Suécia
2014/01/01 - 2017/09/30 Founder and member of the Study Group on Energy Metabolism Centre d'imagerie biomédicale, Suiça
2012/01/01 - 2017/09/30 Animal welfare deputy study director Centre d'imagerie biomédicale, Suiça
Diabetes and Brain Function lab, Suécia
2009/01/01 - 2016/12/31 Manager of the Neurochemistry Laboratory Centre d'imagerie biomédicale, Suiça
Diabetes and Brain Function lab, Suécia
Produções

Publicações

Artigo em revista
  1. João M. N. Duarte. "Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo". Neurochemical Research (2025): https://doi.org/10.1007/s11064-024-04324-4.
    10.1007/s11064-024-04324-4
  2. João P.P. Vieira; Dimitra Karampatsi; Ellen Vercalsteren; Vladimer Darsalia; Cesare Patrone; Joao M.N. Duarte. "Nuclear magnetic resonance spectroscopy reveals biomarkers of stroke recovery in a mouse model of obesity-associated type 2 diabetes". Bioscience Reports (2024): https://doi.org/10.1042/BSR20240249.
    10.1042/BSR20240249
  3. Caroline D. Rae; Joseph A. Baur; Karin Borges; Gerald Dienel; Carlos Manlio Díaz-García; Starlette R. Douglass; Kelly Drew; et al. "Brain energy metabolism: A roadmap for future research". Journal of Neurochemistry (2024): https://doi.org/10.1111/jnc.16032.
    10.1111/jnc.16032
  4. Cecilia Skoug; Oksana Rogova; Peter Spégel; Cecilia Holm; João M. N. Duarte. "Genetic deletion of hormone-sensitive lipase in mice reduces cerebral blood flow but does not aggravate the impact of diet-induced obesity on memory". Journal of Neurochemistry (2024): https://doi.org/10.1111/jnc.16064.
    10.1111/jnc.16064
  5. João MN Duarte; Markus Schwaninger. "Unraveling the brain's response to hypoglycemia: Neurovascular coupling". Journal of Cerebral Blood Flow & Metabolism (2024): https://doi.org/10.1177/0271678X231220082.
    10.1177/0271678X231220082
  6. João P. P. Vieira; Filip Ottosson; Amra Jujic; Vladimir Denisov; Martin Magnusson; Olle Melander; João M. N. Duarte. "Metabolite Profiling in a Diet-Induced Obesity Mouse Model and Individuals with Diabetes: A Combined Mass Spectrometry and Proton Nuclear Magnetic Resonance Spectroscopy Study". Metabolites (2023): https://doi.org/10.3390/metabo13070874.
    10.3390/metabo13070874
  7. Amra Jujic; João P. P. Vieira; Hana Matuskova; Peter M. Nilsson; Ulf Lindblad; Michael H. Olsen; João M. N. Duarte; Anja Meissner; Martin Magnusson. "Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241210064.
    10.3390/ijms241210064
  8. Anja Meissner; Alba M. Garcia-Serrano; Lotte Vanherle; Zeinab Rafiee; Nicholas Don-Doncow; Cecilia Skoug; Sara Larsson; et al. "Alterations to Cerebral Perfusion, Metabolite Profiles, and Neuronal Morphology in the Hippocampus and Cortex of Male and Female Mice during Chronic Exposure to a High-Salt Diet". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms24010300.
    10.3390/ijms24010300
  9. Cecilia Skoug; Isak Martinsson; Gunnar K. Gouras; Anja Meissner; João M. N. Duarte. "Sphingosine 1-Phoshpate Receptors are Located in Synapses and Control Spontaneous Activity of Mouse Neurons in Culture". Neurochemical Research (2022): https://doi.org/10.1007/s11064-022-03664-3.
    10.1007/s11064-022-03664-3
  10. João M. N. Duarte. "Serine racemase modulation for improving brain insulin resistance". Journal of Neurochemistry (2022): https://doi.org/10.1111/jnc.15688.
    10.1111/jnc.15688
  11. Cecilia Skoug; Cecilia Holm; João M.N. Duarte. "Hormone-sensitive lipase is localized at synapses and is necessary for normal memory functioning in mice". Journal of Lipid Research 63 5 (2022): 100195-100195. https://doi.org/10.1016/j.jlr.2022.100195.
    10.1016/j.jlr.2022.100195
  12. Zeinab Rafiee; Alba M. García-Serrano; João M. N. Duarte. "Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes". Nutrients (2022): https://www.mdpi.com/2072-6643/14/6/1292.
    10.3390/nu14061292
  13. Garcia-Serrano, Alba M; Mohr, Adélaïde A; Philippe, Juliette; Skoug, Cecilia; Spégel, Peter; Duarte, João M.N. "Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal". Aging and disease 13 1 (2022): 267. http://dx.doi.org/10.14336/ad.2021.0720.
    10.14336/ad.2021.0720
  14. Kubota, Manabu; Kimura, Yasuyuki; Shimojo, Masafumi; Takado, Yuhei; Duarte, Joao MN; Takuwa, Hiroyuki; Seki, Chie; et al. "Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models". Journal of Cerebral Blood Flow & Metabolism 41 11 (2021): 2928-2943. http://dx.doi.org/10.1177/0271678x211004150.
    10.1177/0271678x211004150
  15. de Bem, Andreza Fabro; Krolow, Rachel; Farias, Hémelin Resende; de Rezende, Victória Linden; Gelain, Daniel Pens; Moreira, José Cláudio Fonseca; Duarte, João Miguel das Neves; de Oliveira, Jade. "Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview". Frontiers in Neuroscience 14 (2021): http://dx.doi.org/10.3389/fnins.2020.604150.
    10.3389/fnins.2020.604150
  16. Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al. "Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes". Brain Research Bulletin 161 (2020): 106-115. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004.
    10.1016/j.brainresbull.2020.05.004
  17. Garcia-Serrano, Alba M.; Duarte, João M. N.. "Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From Diet-Induced Diabetes Models?". Frontiers in Neuroscience 14 (2020): http://dx.doi.org/10.3389/fnins.2020.00229.
    10.3389/fnins.2020.00229
  18. Ana Francisca Soares; Jakob D. Nissen; Alba M. Garcia-Serrano; Sakura S. Nussbaum; Helle S. Waagepetersen; João M. N. Duarte. "Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto-Kakizaki rats". Journal of Neuroscience Research (2019): https://doi.org/10.1002/jnr.24437.
    10.1002/jnr.24437
  19. Duarte, João; Girault, Freya-Merret; Sonnay, Sarah; Gruetter, Rolf; Duarte, João M. N.. "Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by 13C Magnetic Resonance Spectroscopy". Neurotoxicity Research 36 2 (2019): 268-278. http://dx.doi.org/10.1007/s12640-017-9821-y.
    10.1007/s12640-017-9821-y
  20. Duarte, João; Belenguer, Pascale; Duarte, João M. N.; Schuck, Patrícia F.; Ferreira, Gustavo C.. "Mitochondria and the Brain: Bioenergetics and Beyond". Neurotoxicity Research 36 2 (2019): 219-238. http://dx.doi.org/10.1007/s12640-019-00061-7.
    10.1007/s12640-019-00061-7
  21. Duarte, João; Lizarbe, Blanca; Cherix, Antoine; Duarte, João M. N.; Cardinaux, Jean-René; Gruetter, Rolf. "High-fat diet consumption alters energy metabolism in the mouse hypothalamus". International Journal of Obesity 43 6 (2019): 1295-1304. http://dx.doi.org/10.1038/s41366-018-0224-9.
    10.1038/s41366-018-0224-9
  22. Duarte, João. "Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus". Frontiers in Neuroscience (2019): http://dx.doi.org/10.3389/fnins.2018.01015.
    10.3389/fnins.2018.01015
  23. Duarte, João. "Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet". Frontiers in Neuroscience (2019): http://dx.doi.org/10.3389/fnins.2018.00985.
    10.3389/fnins.2018.00985
  24. Duarte, João. "Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism". Neurochemical Research (2019): http://dx.doi.org/10.1007/s11064-018-2521-z.
    10.1007/s11064-018-2521-z
  25. Duarte, João. "Feasibility of in vivo measurement of glucose metabolism in the mouse hypothalamus by 1 H-[13 C] MRS at 14.1T". Magnetic Resonance in Medicine (2018): http://dx.doi.org/10.1002/mrm.27129.
    10.1002/mrm.27129
  26. Duarte, João. "Increased hepatic fatty acid polyunsaturation precedes ectopic lipid deposition in the liver in adaptation to high-fat diets in mice". Magnetic Resonance Materials in Physics, Biology and Medicine (2018): http://dx.doi.org/10.1007/s10334-017-0654-8.
    10.1007/s10334-017-0654-8
  27. Duarte, João. "Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate-glutamine cycle in the tree shrew visual cortex". Glia (2018): http://dx.doi.org/10.1002/glia.23259.
    10.1002/glia.23259
  28. Duarte, João. "Energy metabolism in the rat cortex under thiopental anaesthesia measuredIn Vivoby13C MRS". Journal of Neuroscience Research (2017): http://dx.doi.org/10.1002/jnr.24032.
    10.1002/jnr.24032
  29. Duarte, João. "Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio andmyo-inositol concentration in the mouse frontal cortex". Journal of Neurochemistry (2017): http://dx.doi.org/10.1111/jnc.14116.
    10.1111/jnc.14116
  30. Duarte, João. "Glycogen Supercompensation in the Rat Brain After Acute Hypoglycemia is Independent of Glucose Levels During Recovery". Neurochemical Research (2017): http://dx.doi.org/10.1007/s11064-017-2178-z.
    10.1007/s11064-017-2178-z
  31. Duarte, João. "How Energy Metabolism Supports Cerebral Function: Insights from 13C Magnetic Resonance Studies In vivo". Frontiers in Neuroscience (2017): http://dx.doi.org/10.3389/fnins.2017.00288.
    10.3389/fnins.2017.00288
  32. Duarte, João. "Lactate and glutamate dynamics during prolonged stimulation of the rat barrel cortex suggest adaptation of cerebral glucose and oxygen metabolism". Neuroscience (2017): http://dx.doi.org/10.1016/j.neuroscience.2017.01.034.
    10.1016/j.neuroscience.2017.01.034
  33. Duarte JM; Cunha RA; Carvalho RA. "Adenosine A1 receptors control the metabolic recovery after hypoxia in rat hippocampal slices.". (2016): http://europepmc.org/abstract/med/26709861.
    10.1111/jnc.13512
  34. Sonnay S; Duarte JM; Just N; Gruetter R. "Compartmentalised energy metabolism supporting glutamatergic neurotransmission in response to increased activity in the rat cerebral cortex: A 13C MRS study in vivo at 14.1 T.". (2016): http://europepmc.org/abstract/med/26823472.
  35. Corcoba A; Steullet P; Duarte JM; Van de Looij Y; Monin A; Cuenod M; Gruetter R; Do KQ. "Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia.". (2015): http://europepmc.org/abstract/med/26433393.
  36. Duarte JM. "Metabolic Alterations Associated to Brain Dysfunction in Diabetes.". (2015): http://europepmc.org/abstract/med/26425386.
    10.14336/AD.2014.1104
  37. Duarte JM; Girault FM; Gruetter R. "Brain energy metabolism measured by (13)C magnetic resonance spectroscopy in vivo upon infusion of [3-(13)C]lactate.". (2015): http://europepmc.org/abstract/med/25522255.
    10.1002/jnr.23531
  38. Sonnay S; Just N; Duarte JM; Gruetter R. "Imaging of prolonged BOLD response in the somatosensory cortex of the rat.". (2015): http://europepmc.org/abstract/med/25702944.
    10.1002/nbm.3263
  39. Duarte JM; Schuck PF; Wenk GL; Ferreira GC. "Metabolic disturbances in diseases with neurological involvement.". (2014): http://europepmc.org/abstract/med/25110608.
    10.14336/AD.2014.0500238
  40. Duarte JM; Do KQ; Gruetter R. "Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy.". (2014): http://europepmc.org/abstract/med/24560998.
    10.1016/j.neurobiolaging.2014.01.135
  41. Alf MF; Duarte JM; Lei H; Krämer SD; Mlynarik V; Schibli R; Gruetter R. "MRS glucose mapping and PET joining forces: re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia.". (2014): http://europepmc.org/abstract/med/24471521.
    10.1111/jnc.12667
  42. Alf MF; Duarte JM; Schibli R; Gruetter R; Krämer SD. "Brain glucose transport and phosphorylation under acute insulin-induced hypoglycemia in mice: an 18F-FDG PET study.". (2013): http://europepmc.org/abstract/med/24159048.
    10.2967/jnumed.113.122812
  43. Duarte JM; Gruetter R. "Glutamatergic and GABAergic energy metabolism measured in the rat brain by (13) C NMR spectroscopy at 14.1 T.". (2013): http://europepmc.org/abstract/med/23745684.
    10.1111/jnc.12333
  44. Bastiaansen JA; Cheng T; Mishkovsky M; Duarte JM; Comment A; Gruetter R. "In vivo enzymatic activity of acetylCoA synthetase in skeletal muscle revealed by (13)C turnover from hyperpolarized [1-(13)C]acetate to [1-(13)C]acetylcarnitine.". (2013): http://europepmc.org/abstract/med/23545238.
    10.1016/j.bbagen.2013.03.023
  45. Lanz B; Gruetter R; Duarte JM. "Metabolic Flux and Compartmentation Analysis in the Brain In vivo.". (2013): http://europepmc.org/abstract/med/24194729.
    10.3389/fendo.2013.00156
  46. Cudalbu C; McLin VA; Lei H; Duarte JM; Rougemont AL; Oldani G; Terraz S; Toso C; Gruetter R. "The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts.". (2013): http://europepmc.org/abstract/med/23936100.
    10.1371/journal.pone.0069782
  47. Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A.. "CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus". Neurochemistry International 60 1 (2012): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS.
    10.1016/j.neuint.2011.10.019
  48. Duarte, J.M.N.; Agostinho, P.M.; Carvalho, R.A.; Cunha, R.A.. "Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of nonczno10/ltj mice". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859733227&partnerID=MN8TOARS.
    10.1371/journal.pone.0021899
  49. Cudalbu, C.; Lanz, B.; Duarte, J.M.N.; Morgenthaler, F.D.; Pilloud, Y.; Mlynárik, V.; Gruetter, R.. "Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized 1H and 15N NMR spectroscopy". Journal of Cerebral Blood Flow and Metabolism 32 4 (2012): 696-708. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859432226&partnerID=MN8TOARS.
    10.1038/jcbfm.2011.173
  50. Duarte, J.M.N.; Gruetter, R.. "Characterization of cerebral glucose dynamics in vivo with a four-state conformational model of transport at the blood-brain barrier". Journal of Neurochemistry 121 3 (2012): 396-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859592535&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2012.07688.x
  51. Duarte, J.M.N.; Lei, H.; Mlynárik, V.; Gruetter, R.. "The neurochemical profile quantified by in vivo 1H NMR spectroscopy". NeuroImage 61 2 (2012): 342-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860713083&partnerID=MN8TOARS.
    10.1016/j.neuroimage.2011.12.038
  52. Lanz, B.; Duarte, J.M.N.; Kunz, N.; Mlynárik, V.; Gruetter, R.; Cudalbu, C.. "Which prior knowledge? Quantification of in vivo brain 13C MR spectra following 13C glucose infusion using AMARES". Magnetic Resonance in Medicine (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84864538279&partnerID=MN8TOARS.
    10.1002/mrm.24406
  53. Das Neves Duarte, J.M.; Kulak, A.; Gholam-Razaee, M.M.; Cuenod, M.; Gruetter, R.; Do, K.Q.. "N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development". Biological Psychiatry 71 11 (2012): 1006-1014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861039574&partnerID=MN8TOARS.
    10.1016/j.biopsych.2011.07.035
  54. Duarte, J.M.N.; Lanz, B.; Gruetter, R.. "Compartmentalized cerebral metabolism of [1,6- 13C]glucose determined by in vivo 13C NMR spectroscopy at 14.1 T". Frontiers in Neuroenergetics JUN (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855862624&partnerID=MN8TOARS.
    10.3389/fnene.2011.00003
  55. Lei, H.; Duarte, J.M.N.; Mlynarik, V.; Python, A.; Gruetter, R.. "Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex". Journal of Neuroscience Research 88 2 (2010): 413-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-74049124295&partnerID=MN8TOARS.
    10.1002/jnr.22212
  56. Xin, L.; Gambarota, G.; Duarte, J.M.N.; Mlynárik, V.; Gruetter, R.. "Direct in vivo measurement of glycine and the neurochemical profile in the rat medulla oblongata". NMR in Biomedicine 23 9 (2010): 1097-1102. http://www.scopus.com/inward/record.url?eid=2-s2.0-79251514306&partnerID=MN8TOARS.
    10.1002/nbm.1537
  57. Duarte, J.M.N.; Carvalho, R.A.; Cunha, R.A.; Gruetter, R.. "Erratum: Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats (Journal of Neurochemistry (2009) 111 (368-379))". Journal of Neurochemistry 112 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-71649088232&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2009.06444.x
  58. Santiago, A.R.; Garrido, M.J.; Cristóvão, A.J.; Duarte, J.M.N.; Carvalho, R.A.; Ambrósio, A.F.. "Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy". Current Eye Research 35 11 (2010): 992-1001. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958505485&partnerID=MN8TOARS.
    10.3109/02713683.2010.500113
  59. Kulak, A.; Duarte, J.M.N.; Do, K.Q.; Gruetter, R.. "Neurochemical profile of the developing mouse cortex determined by in vivo 1H NMR spectroscopy at 14.1 T and the effect of recurrent anaesthesia". Journal of Neurochemistry 115 6 (2010): 1466-1477. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649988282&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2010.07051.x
  60. Duarte, J.M.N.; Carvalho, R.A.; Cunha, R.A.; Gruetter, R.. "Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats". Journal of Neurochemistry 111 2 (2009): 368-379. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349338971&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2009.06349.x
  61. Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A.. "Modification upon aging of the density of presynaptic modulation systems in the hippocampus". Neurobiology of Aging 30 11 (2009): 1877-1884. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2008.01.003
  62. Duarte, J.M.N.; Cunha, R.A.; Carvalho, R.A.. "Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy". Neuroscience 144 4 (2007): 1305-1313. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846274201&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2006.11.027
  63. Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A.. "Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats". Experimental Neurology 204 1 (2007): 479-484. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS.
    10.1016/j.expneurol.2006.11.013
  64. Duarte, J.M.N.; Oses, J.P.; Rodrigues, R.J.; Cunha, R.A.. "Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats". Neuroscience 149 2 (2007): 382-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2007.08.005
  65. Duarte, J.M.N.; Oliveira, C.R.; Ambrósio, A.F.; Cunha, R.A.. "Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats". Neurochemistry International 48 2 (2006): 144-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244450466&partnerID=MN8TOARS.
    10.1016/j.neuint.2005.08.008
Pré-impressão
  1. Gabriela C. De Paula; Blanca Aldana; Roberta Battistella; Rosalia Fernández Calle; Andreas Bjure; Iben Lundgaard; Tomas Deierborg; João M. N. Duarte. "Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolism". 2024. https://doi.org/10.1101/2024.04.04.587954.
    10.1101/2024.04.04.587954
  2. Joao Vieira; Amra Jujic; Hana Matuskova; Peter M. Nilsson; Ulf Lindblad; Michael Hecht Olsen; João M.N. Duarte; Anja Meissner; Martin Magnusson. "Plasma Galectin-4 Levels are Increased after Stroke in Mice and Humans". 2023. https://doi.org/10.20944/preprints202303.0373.v1.
    10.20944/preprints202303.0373.v1

Outros

Outra produção
  1. Cognitive impairment and metabolite profile alterations in the hippocampus and cortex of male and female mice exposed to a fat and sugar-rich diet are normalized by diet reversal. 2021. Alba M. Garcia-Serrano; Adélaïde A. Mohr; Peter Spégel; João M.N. Duarte. https://doi.org/10.1101/2021.04.27.441603.
    10.1101/2021.04.27.441603
  2. A glucose-stimulated BOLD fMRI study of hypothalamic dysfunction in mice fed a high-fat and high-sucrose diet. Journal of Cerebral Blood Flow & Metabolism. 2020. Adélaïde A. Mohr; Alba M. Garcia-Serrano; João P.P. Vieira; Cecilia Skoug; Henrik Davidsson; João M.N. Duarte; Mohr, Adélaïde A; et al. https://doi.org/10.1101/2020.03.21.001149.
    10.1101/2020.03.21.001149
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024 “Brain dysfunction in insulin resistant models” Steno-Lund Cardiometabolic Precision Medicine Symposium
2024 “Diabetes and Dementia: what are we learning from preclinical research?” Diabetes day, Malmo, Nov 14.
2024 “Brain function and Insulin resistance”, The Swedish CArdioMetabolic Network (SCAMN), Sep 9-10.
2024 “Regulation of cerebral blood flow and mitochondrial metabolism in animal models of insulin resistance”, SFRR-E Redox Biology Congress, Jun 5-7
2024 “Microgliosis driven by palmitate exposure alters energy metabolism and released extracellular vesicles that impact behavior and systemic metabolism”, Rush Alzheimer’s Disease Center, April 3
2024 "Brain dysfunction in insulin resistance involves impaired fuelling of neuronal activity". Augsburg University Faculty of Medicine, Germany, Jan 31
2023 “Brain metabolism in rodent models studied by 1H and 13C MRS”, Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Copenhagen, Sep 11.
2023 “Impact of insulin resistance on energy metabolism of neurons and glial cells”, ISN-ESN Meeting, Porto, Aug 8-11.
2023 “Brain metabolism in rodent models studied by 1H and 13C MRS”, 46th annual meeting of the Japan Neuroscience Society, Sendai, Aug 1-4
2023 “Hormone-sensitive lipase contributes for brain metabolism regulation, and its deletion impairs memory in aged mice”, Post-graduation program in Biochemistry and Biomedicine, Federal University of Pernambuco, Recife-Brasil, May 5.
2023 “Hormone-sensitive lipase contributes for brain metabolism regulation, and its deletion impairs memory in aged mice”, Seminário Antonio Luiz Vianna, Federal University of Rio de Janeiro, Brasil, May 4.
2023 “Hormone-sensitive lipase contributes for brain metabolism regulation, and its deletion impairs memory in aged mice”, Post-graduation program in Biochemistry and Biomedicine, Federal University of Santa Catarina, Florianopolis-Brasil, May 2.
2022/03/10 Brain dysfunction in obesity-associated insulin resistance Diabesity Nordic
(Solstrand, Noruega)
2022 “Hormone-sensitive lipase contributes for brain metabolism regulation, and its deletion impairs memory in aged mice”, 14th International Conference on Brain Energy Metabolism (ICBEM), Santa Fé, USA, Oct 26.
2022 “Diet and their effect on metabolic diseases: results from in vivo”, FightSterol webinar, Aveiro University, Jul 22.
2022 “Impact of metabolic syndrome on brain metabolism and function”, Brain & Brain PET meeting, Glasgow, Jun 1.
2022 “Brain dysfunction in obesity-associated insulin resistance”, Nordic Diabesity meeting, Solstrand, Norway, Mar 9-11.
2022 “Impact of metabolic syndrome on brain metabolism and function”, Inflammation and Metabolism network, University of Copenhagen, Feb 25.
2021 “Impact of metabolic syndrome on brain metabolism and function”, 7th MetNet International Annual Meeting, Barcelona, Oct 8.
2021 “Glutamate-glutamine cycling and the oxidative metabolism rate in astrocytes”. 20th Society for Free Radical Research International. Virtual Conference, Mar 16.
2020 Alterações cerebrais associadas aos modelos experimentais de Diabetes mellitus XLIII Reunião Anual da SBNeC
(Brasil)
2020 I Did Not Know MRS Can Do That! Insights into Neuronal Activation from fMRS ISMRM 2020 Virtual Conference
2020 Magnetic Resonance studies in vivo to investigate brain metabolism in type 2 diabetes
Federal University of Rio de Janeiro
2020 Metabolic profiling in the insulin-resistant brain: Magnetic Resonance studies in vivo
University of Brasilia
2019 “Impact of insulin resistance on brain energy metabolism”. Graduate program in Pharmaceutical Sciences, University of Copenhagen, Oct 10.
2019 “Metabolic profiling in the insulin-resistant brain: Magnetic Resonance studies in vivo”. Linköping University, Sweden, Sep 20.
2019 “Glutamate-glutamine cycling and oxidative metabolism in astrocytes from the perspective of magnetic resonance spectroscopy in vivo”. International Society for Neurochemistry, Montreal, Canada, Aug 4-8.
2019 “Brain energy metabolism in type 2 diabetes: insights from insulin resistant animal models”. Dep. Functional Brain Imaging Research, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, Jul 2.
2019 “Brain energy metabolism in insulin-resistant diabetes”, EASD-EGIR meeting, Lisbon, Portugal, May 9-10.
2019 “Starting a Biomedical Research Group: the value of mobility”, Lund University Future Faculty retreat, Flädie, Apr 11.
2018 “Impact of insulin-resistant diabetes on the energy metabolism of neurons and astrocytes”, Neuro-ImunoMetabolismo em Obesidade e Doenças Metabólicas, Florianópolis, Brasil, Oct 26-27.
2018 “Metabolic flux analysis in vivo using 13C magnetic resonance spectroscopy: insight into neuron-astrocyte interactions”, Maastricht Centre for Systems Biology (MaCSBio) - Keynote speaker at the 3rd MaCSBio Science Day, Maastricht, The Netherlands, Jun 1.
2018 “Starting an interdisciplinary biomedical research group in an institution abroad”, DPLU Methodology day, Malmo, Sweden, Mar 16.
2018 “Brain energy metabolism studied in vivo by NMR”, MoReLife “NMR and metabolomics day at LU”, Feb 28.
2018 “Brain energy metabolism in type 2 diabetes”, LUDC/DPLU Diabetes Research Day, Malmo, Sweden, Feb 13.
2017 “Brain metabolic alterations underlying neurodegeneration in type 2 diabetes”, Clinical Research Centre, Malmo, Sweden, May 4.
2017 “Brain metabolic alterations in insulin-resistant Goto-Kakizaki rats: a magnetic resonance study in vivo”, Clinical Research Centre, Malmö, Sweden, Jan 16.
2016 “Alterations of brain metabolism in type 2 diabetes: a magnetic resonance study in vivo”, Symposium “Energizing the CNS: from biomarker to treatment” TRAIL, Bordeaux, Nov 7.
2016 “Alterations of brain energy metabolism in insulin resistance”, 12th Workshop of the International School on Magnetic Resonance and Brain Function, Erice, Sicily, Apr 30-May 6.
2015 “Neurodegeneration and cerebral metabolic deterioration in insulin resistance”, Brain Research Institute, University of Zurich, Sep 2.
2015 “Metabolic deterioration underlying impaired memory performance in insulin resistance”, 25th Meeting of the International Society for Neurochemistry, Cairns, Australia, Aug 23-27.
2015 “Neuron-glia metabolic coupling and metabolic features of neurodegeneration in insulin resistance”, Life Sciences School, University of Nottingham, Aug 5.
2015 “Metabolic deterioration underlying impaired memory performance in insulin resistance”, Faculty of Medicine, Eberhard Karls Universität Tübingen, Jul 2.
2015 “Energy metabolism, neurochemical profiles and brain morphology in insulin resistance”, Center for Psychiatric Neuroscience, CHUV, Switzerland, Jan 19.
2014 “Deterioration of neuronal and glial intermediary metabolism, neurochemical profiles and brain morphology in insulin-resistant Goto-Kakizaki rats: a multimodal magnetic resonance study in vivo”, 19th Congress of the Portuguese Biochemical Society, Coimbra, Portugal, Dec 17-20.
2014 “Impact of hyperglycaemia and insulin resistance on brain metabolism, morphology and function”, 11th ICBEM, “How Energy Metabolism Shapes Brain Function”, Bymosehegn, Helsinge, Denmark, May 11-14.
2014 “Magnetic resonance spectroscopy in Gclm knock-out mice: perspectives”, NCCR Synapsy - Meeting Axe I Lausanne: Biomarkers in early psychosis, Prilly, Switzerland, Jan 29.
2013 “N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development”, NCCR Synapsy - Meeting Axe I Lausanne: Biomarkers in early psychosis, Prilly, Switzerland, Mar 14.
2011 “Imaging brain metabolism in vivo”, FENS-IBRO Imaging Training Center 2011, Lausanne & Geneva, Switzerland, Aug 28-Sep 16.
2009 “Insights on in vivo glucose and glycogen metabolism”, ISN/APSN joint meeting, Busan, South Korea, Aug 24.

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022 - Atual Brain ApoE lipid trafficking
Coorientador
Lunds Universitet, Suécia
2022 - Atual Cerebrovascular function
Coorientador
Lunds Universitet, Suécia
2022 - Atual Diet and neuroinflammation in Alzheimer’s Disease
Orientador
Lunds Universitet, Suécia
2018 - Atual Supervised over 20 M.Sc. thesis
Orientador
Lunds Universitet, Suécia
2019 - 2024 Profiling Plasma Metabolite Alterations in Diet-Induced Obesity and Diabetes Using NMR Metabolomics
Orientador
Lunds Universitet Institutionen för Experimentell Medicinsk Vetenskap, Suécia
2019 - 2023 Bioactive lipids as neuroprotective targets in type 2 diabetes
Orientador
Lunds Universitet Institutionen för Experimentell Medicinsk Vetenskap, Suécia

Linköping University, Suécia
2014 - 2018 Supervised 3 MSc students
Orientador
École Polytechnique Fédérale de Lausanne, Suiça
2012 - 2017 “Study of cortical energy metabolism during sensory stimulation-induced brain activity by 13C magnetic resonance spectroscopy in vivo”
Orientador
École Polytechnique Fédérale de Lausanne, Suiça
2011 - 2016 “Redox dysregulation in schizophrenia: effect on myelination of cortical structures and connectivity”
Coorientador
Centre Hospitalier Universitaire Vaudois Centre de neurosciences psychiatriques, Suiça

Linköping University, Suécia

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024 Genetic and phenotypic discordance in cardiometabolic diseases
Vogal
 Daniel Coral (Doutoramento)
2024 Mathematical Modelling of Cerebral Metabolism - From Ion Channels to Metabolic Fluxes
Arguente principal
 Nicolas Sundqvists (Doutoramento)
Linköping University, Suécia
2024 Eyes on Alzheimer’s: Retinal Pathology in Early Alzheimer's Disease, Insights from Mouse Models
Arguente principal
 Mariana YG Bermudez (Doutoramento)
Copenhagen University, Dinamarca
2023 Answers of big biological data to unsolved diabetes questions - Unveiling causes of impaired ß-cell insulin secretion
Vogal
 Alexandros Karagiannopoulos (Doutoramento)
2023 Sex differences in behavior and metabolism
Vogal
 Ivana Maric (Doutoramento)
2022 Role of Ca2+-activated sAC and AC8 in astrocytic glycogen metabolism
Arguente principal
 Emil Jakobsen (Doutoramento)
Københavns Universitet, Dinamarca
2022 The role of alpha-amylase in healthy and Alzheimer’s dementia brain
Arguente
 Elin Byman Shatri (Doutoramento)
Lunds universitet Medicinska fakulteten, Suécia
2022 The synaptic and neurobiological role of apolipoprotein E4 in models of Alzheimer's disease
Presidente do júri
 Sabine Konings (Doutoramento)
Lunds universitet Medicinska fakulteten, Suécia
2022 Shining infrared light on amyloid structures in neurodegenerative proteinopathies.
Presidente do júri
 Agnes Paulus (Doutoramento)
2022 Thyrotropin-releasing hormone and bile acid signaling in vagal nodose ganglion neurons
Arguente principal
 Esmira Mamedova (Doutoramento)
Copenhagen University, Dinamarca
2022 Tau, bridging the gap between Alzheimer's and Parkinson's diseases
Arguente
 Laura Torres-Garcia (Doutoramento)
2022 Mesenchymal heterogeneity in the adult human lung
Vogal
 Måns Kadefors (Doutoramento)
2021 Tracing hepatic glycogen and lipid metabolism with stable isotope tracers: insights from murine studies
Arguente principal
 Giada di Nunzio (Doutoramento)
Universidade de Coimbra, Portugal
2021 Cerebral regulation of global energy balance in health and disease as detected by functional diffusion weighted MRI
Arguente principal
 Irene Guadilla Gómez (Doutoramento)
Universidad Autónoma de Madrid, Espanha
2020 Neurovascular coupling Sebastian Sten (Doutoramento)
Linköping University, Suécia
2020 Brain energy metabolism Lavanya Achanta (Doutoramento)
University of New South Wales, Austrália
2019 Brain energy metabolism Sofie Kjellerup Christensen (Doutoramento)
Copenhagen University, Dinamarca

Arbitragem científica em conferência

Nome da conferência Local da conferência
2025 - 2025 Program Committee, 25th ESN Biennial Meeting - 31st HSFN Meeting, May 18-21, Naxos, Greece European Society for Neurochemistry
2024 - 2024 Program Committee for the ICBEM 2024, Slovenia, Sep 17-21 International Conference on Brain Energy Metabolism (ICBEM)
2023 - 2024 Abstract reviewer, European Molecular Imaging Meeting (EMIM) European Molecular Imaging Meeting (EMIM)
2022 - 2022 Symposium organizer, “Brain metabolism by MRS: State-of-the-art and recent advances” International Society for Neurochemistry meeting, Honolulu, Aug 28-Sep 1.
2022 - 2022 Symposium organizer, "Role of insulin signaling in the brain metabolism" Brain & Brain PET meeting, Glasgow, May 29-Jun 1.
2022 - 2022 Symposium organizer, “Role of insulin signalling in the brain” 24th European Society for Neurochemistry Biennial Meeting, Saint Petersburg, Russia, May 22-25 (meeting cancelled).
2021/05/31 - 2021/06/02 CAPES-STINT Seminar series “Brain dysfunction in metabolic disease models” Online symposium
2019/01/01 - 2019/12/31 Retreat organising committee, Dep. Experimental Medical Science
2019/01/01 - 2019/12/31 Organising committee for WCMM research day
2018/01/01 - 2019/12/31 Program committee member for LUDC/Exodiab retreat
2016/01/01 - 2018/12/31 ICBEM Scientific Program Committee member

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2022/01/01 - Atual Journal of Neurochemistry
2020/01/01 - Atual Neurochemical Research
2019/01/01 - Atual Frontiers in Cell and Developmental Biology
2015/01/02 - Atual Anais da Academia Brasileira de Ciências
2013/01/01 - Atual Journal of Cerebral Blood Flow & Metabolism
2021 - 2022 Frontiers in Neuroscience: “Obesity and Diabetes: Implications for Brain-Immunometabolism - Volume II”
2019/01/01 - 2019/12/31 Neurotoxicity Research
2017/01/01 - 2017/12/31 Neural Plasticity
2014/01/01 - 2017/12/31 HSOA Journal of Diabetes and Metabolic Disorders

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2021 - Atual Reviewer for DPLU PhD student grants
Avaliador
 Lund University Diabetes Centre, Suécia Lund University Diabetes Centre
2021 - Atual Committee chair for “Leif Groop Young Scientist Scholarship at Lund University” Lund University Diabetes Centre, Suécia Novo Nordisk Scandinavia AB
2015/01/01 - Atual Peer review of Brain & Brain PET meeting abstracts
Avaliador
2019 - 2020 Reviewer for the Frontier Science 2019 Call, CONACYT, Mexico Government
2019 - 2019 Project reviewer for Sapienza Research Committee of the Sapienza University of Rome, Italy
2015/01/01 - 2018/12/31 Grant reviewer for Swiss National Science Foundation
Avaliador
2011/01/01 - 2018/12/31 Peer review of ISMRM meeting abstracts
Avaliador
2018 - 2018 Reviewer of European Commission ERC Advanced Grant
Avaliador
2015 - 2015 Grant reviewer for Diabetes UK
Avaliador
2013/01/01 - 2013/12/31 Grant proposal reviewer for National Science Centre, Poland
Avaliador

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2015/01/01 - Atual Travel Grant Committee member, International Society for Neurochemistry
Membro
 International Society for Neurochemistry, Suiça
2023 - 2027 Council member, International Society for Neurochemistry
Membro
Distinções

Prémio

2024 Best Editor of the Year, Journal of Neurochemistry
2024 2024 Medeon prize
2020 Young IBRO Regions Connecting Award
2017 Wallenberg Fellowship in Molecular Medicine
2017 suma cum laude Merit Award, 25th ISMRM
2015 Young Investigator Symposium, 25th Meeting of the International Society for Neurochemistry
2015 magna cum laude Merit Award, 23rd ISMRM
2015 Brain 2015 Young Investigator travel bursary
2014 Travel Award, International Conference on Brain Energy Metabolism
2012 Fellowship for the FEBS Young Scientists Program
2012 magna cum laude Merit Award, 20th ISMRM
2011 ISN travel award, 23rd Biennial Meeting of the International Society for Neurochemistry
2011 Brain 2011 Young Investigator travel bursary
2010 Educational Stipend, Joint Annual Meeting ISMRM-ESMRMB
2009 Travel award of the 22nd Biennial Meeting of the International Society for Neurochemistry
2009 Educational Stipend, 17th ISMRM
2008 Educational Stipend, 16th ISMRM
2007 Travel award, 8th ISN Advanced School of Neurochemistry
2006 Fellowship, Fundação Calouste Gulbenkian
2006 Travel Award for Young Scientists, International Conference on Brain Energy Metabolism
2004 Student support program of ESMRMB

Título

2019 Docent in Neurometabolism, Faculty of Medicine, Lund University