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Armindo José Alves da Silva Salvador graduated in Biochemistry by the University of Lisbon in 1988, and obtained a Ph. D. in Biochemistry in 1997 from the same University. He was a post-doctoral fellow at the Institute for Chemical and Biological Technology (Portugal) (1997-8, Membrane Biophysics), at the University of Michigan (U.S.A.) (1998-2000, Computational Systems Biology) and at the University of Coimbra (Portugal) (2002-5, Molecular Systems Biology), a research fellow at Pfizer Global Research & Development/The University of Michigan (2000-2) and a visiting scholar at the University of California - Davis (U.S.A.) (2002, Molecular Systems Biology). Since 2005 he leads the Computational and Systems Biology Group at the Center for Neuroscience and Cell Biology - The University of Coimbra. Dr. Armindo Salvador's main research interests are focused on the relationship between function and design in signaling and metabolic networks, with emphasis on redox signaling and antioxidant protection. His work in this area has been published in prestigious journals such as Nature Biotechnology, PNAS (3), PLoS Computational Biology, Redox Biology, and Free Radical Biology and Medicine, in papers where he is first, corresponding and/or senior author. Being committed to advanced education in systems and computational biology, Dr. Salvador organized numerous courses and symposia in this area, and coordinates the "International Summer School in Computational Biology - from molecules to tissues" since 2015. He is currently the President of the Portuguese Biophysical Society (2021-), and member of the Editorial Board of the Journal of Theoretical Biology (2009-).
Identificação

Identificação pessoal

Nome completo
Armindo José Alves da Silva Salvador

Nomes de citação

  • Salvador, Armindo

Identificadores de autor

Ciência ID
F216-6359-1F89
ORCID iD
0000-0002-4442-4900

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2002/04/01 - 2005/06/30
Concluído
Molecular Systems Biology (Pós-doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2000/04/01 - 2002/03/01
Concluído
Computational Systems Biology (Pós-doutoramento)
Pfizer Global Research and Development Ann Arbor, Estados Unidos
1998/04/01 - 2000/03/31
Concluído
Molecular Systems Biology (Pós-doutoramento)
University of Michigan Medical School, Estados Unidos
1997/04/01 - 1998/03/31
Concluído
Membrane biophysics (Pós-doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1997/02/27
Concluído
Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Development of methodology and software for analysis of kinetic models of metabolic processes. Application to the mitochondrial metabolism of lipid hydroperoxides" (TESE/DISSERTAÇÃO)
Aprovado com Distinção e Louvor por unanimidade
1988/02/01
Concluído
Biochemistry (Mestrado integrado)
Universidade de Lisboa, Portugal
17
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2005/07/01 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2002/07/01 - 2005/06/30 Pós-doutorado (Investigação) Universidade de Coimbra Departamento de Química, Portugal
2000/04/01 - 2002/03/31 Pós-doutorado (Investigação) Pfizer Global Research and Development Ann Arbor, Estados Unidos
1998/04/01 - 2000/03/31 Pós-doutorado (Investigação) University of Michigan Medical School, Estados Unidos
1997/04/01 - 1998/03/31 Pós-doutorado (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2021/02/08 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/09/01 - 2013/07/31 Professor Auxiliar Convidado (Docente Universitário) Universidade de Coimbra Departamento de Química, Portugal
Projetos

Bolsa

Designação Financiadores
2016 - 2019/06 Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma
PTDC/BIM-ONC/ 7121/2014
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2016 - 2019/06 Unraveling the rules of passive permeation through the bloodbrain barrier
PTDC/DTP-FTO/ 2784/2014
Orientador
Universidade de Coimbra Centro de Química de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2012 - 2015/09 Finding the naturally evolved design principles of prevalent metabolic circuits
Provided by PTCRIS: 119657
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2013/02 Derivative-Free Optimization: Future Challenges and New Applications
Provided by PTCRIS: 98214
PTDC/MAT/098214/2008
Orientador
Fundação para a Ciência e a Tecnologia, I.P.
2008 - 2011/12 Reconstruction and systems analysis of the reaction networks of reactive oxygen, nitrogen and sulfur species in representative physiological systems
Provided by PTCRIS: 70523
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2010/09 Quantitative Modeling of Passive Trancytotic Diffusion of Amphiphilic Molecules Across the Blood-Brain Barrier
Provided by PTCRIS: 69072
PTDC/SAU-FCF/69072/2006
Orientador
Universidade de Coimbra Centro de Química de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2008/12/31 Quantitative evolutionary principles in yeast stress response
E6-07
Investigador responsável
Conselho de Reitores das Universidades Portuguesas, Portugal
Conselho de Reitores das Universidades Portuguesas
Produções

Publicações

Artigo em conferência
  1. A. N. Dias, Paulo; Seabra dos Reis, Marco; Martins, Pedro; Salvador, Armindo. "Identifying Strong Statistical Bias in the Local Structure of Metabolic Networks - The Metabolic Network of Saccharomyces Cerevisiae as a Test Case". Trabalho apresentado em BIOINFORMATICS 2015. 6th International Conference on Bioinformatics Models, Methods and Algorithms, Lisbon, 2015.
    Publicado • 10.5220/0005258102070212
  2. Salvador, Armindo; Moura, Alexandra; Alves, Rui. "Proteome reactivities with the hydroxyl radical reflect organisms’ environmental exposure to oxygen". Trabalho apresentado em INForum2011, Coimbra, 2011.
    Publicado
  3. Villaprinyó, Ester; Alves, Rui; Sorribas, Albert; Salvador, Armindo. "Gene expression levels in Saccharomyces cerevisiae strongly reflect energetic cost rates of gene product". Trabalho apresentado em International Conference on Molecular Systems Biology, Diliman, 2008.
    Publicado
  4. Villaprinyó, Ester; Alves, Rui; Salvador, Armindo; Sorribas, Albert. "Energetic constraints in adaptive gene expression responses of yeast under environmental changes". Trabalho apresentado em International Conference on Molecular Systems Biology, Diliman, 2008.
    Publicado
  5. Coelho, Pedro M. B. M.; Salvador, Armindo; Savageau, M.A.. "Global Tolerance of Biochemical Systems and the Design of Moiety-Transfer Cycles". Trabalho apresentado em International Conference on Molecular Systems Biology, Diliman, 2008.
    Publicado
  6. Antunes, Fernando; Salvador, Armindo; Pinto, Ruy. "Kinetic study of lipid peroxidation mechanism". Trabalho apresentado em VII Biennial Meeting of the International Society for Free Radical Research, Barcelona, 1997.
    Publicado
  7. Salvador, Armindo. "Steady-state synergisms in kinetic models: estimation and applications". Trabalho apresentado em 4th International Conference on Soft Computing, Iizuka, 1996.
    Aceite para publicação
  8. Salvador, Armindo; Garcia, João; Sousa, João; Antunes, Fernando; Alves, Rui; Pinto, Ruy. "PARSYS – A tool for theoretical analysis of metabolic processes". Trabalho apresentado em 4th International Conference on Soft Computing, Iizuka, 1996.
    Publicado
  9. Salvador, Armindo; Antunes, Fernando. "Simulation and analysis of a complex biochemical process: lipid peroxidation in inner mitochondrial membranes". Trabalho apresentado em 1st Copenhagen Symposium on Computer Simulation in Biology, Ecology and Medicine, Lyngby, 1993.
    Publicado
Artigo em revista
  1. Peskin, Alexander V.; Meotti, Flávia C.; de Souza, Luiz F.; Anderson, Robert F.; Winterbourn, Christine C.; Salvador, Armindo. "Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2". Free Radical Biology and Medicine 158 (2020): 115-125. http://dx.doi.org/10.1016/j.freeradbiomed.2020.07.007.
    Publicado • 10.1016/j.freeradbiomed.2020.07.007
  2. Filipe, Hugo A. L.; Javanainen, Matti; Salvador, Armindo; Galvão, Adelino M.; Vattulainen, Ilpo; Loura, Luís M. S.; Moreno, Maria João. "Quantitative Assessment of Methods Used To Obtain Rate Constants from Molecular Dynamics Simulations—Translocation of Cholesterol across Lipid Bilayers". Journal of Chemical Theory and Computation 14 7 (2018): 3840-3848. http://dx.doi.org/10.1021/acs.jctc.8b00150.
    Publicado • 10.1021/acs.jctc.8b00150
  3. Selvaggio, G.; Coelho, P.M.B.M.; Salvador, A.. "Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin – Thioredoxin system. 1. Understanding commonalities and differences among cell types". Redox Biology 15 (2018): 297-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-85039867388&partnerID=MN8TOARS.
    10.1016/j.redox.2017.12.008
  4. Travasso, R.D.M.; Sampaio dos Aidos, F.; Bayani, A.; Abranches, P.; Salvador, A.. "Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling". Redox Biology 12 (2017): 233-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014574052&partnerID=MN8TOARS.
    10.1016/j.redox.2017.01.003
  5. Miranda-Santos, Ines; Gramacho, Silvia; Pineiro, Marta; Martinez-Gomez, Karla; Fritz, Michel; Hollemeyer, Klaus; Salvador, Armindo; Heinzle, Elmar. "Mass Isotopomer Analysis of Nucleosides Isolated from RNA and DNA Using GC/MS". Analytical Chemistry 87 1 (2015): 617-623. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000347590400063&KeyUID=WOS:000347590400063.
    10.1021/ac503305w
  6. Filipe, H. A. L.; Salvador, A.; Silvestre, J. M.; Vaz, W. L. C.; Moreno, M. J.. "Beyond Overton’s Rule: Quantitative Modeling of Passive Permeation through Tight Cell Monolayers". Molecular Pharmaceutics 11 10 (2014): 3696-3706. http://dx.doi.org/10.1021/mp500437e.
    Publicado • 10.1021/mp500437e
  7. Estronca, L.M.B.B.; Filipe, H.A.L.; Salvador, A.; Moreno, M.J.; Vaz, W.L.C.. "Homeostasis of free cholesterol in the blood: A preliminary evaluation and modeling of its passive transport". Journal of Lipid Research 55 6 (2014): 1033-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660412&partnerID=MN8TOARS.
    10.1194/jlr.M043067
  8. Benfeitas, R.; Selvaggio, G.; Antunes, F.; Coelho, P.M.B.M.; Salvador, A.. "Hydrogen peroxide metabolism and sensing in human erythrocytes: A validated kinetic model and reappraisal of the role of peroxiredoxin II". Free Radical Biology and Medicine 74 (2014): 35-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904329372&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2014.06.007
  9. Coelho, P.M.B.M.; Salvador, A.; Savageau, M.A.. "Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes". PLoS ONE 5 9 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77958545833&partnerID=MN8TOARS.
    10.1371/journal.pone.0013031
  10. Savageau, M.A.; Coelho, P.M.B.M.; Fasani, R.A.; Tolla, D.A.; Salvador, A.. "Phenotypes and tolerances in the design space of biochemical systems". Proceedings of the National Academy of Sciences of the United States of America 106 16 (2009): 6435-6440. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149108427&partnerID=MN8TOARS.
    10.1073/pnas.0809869106
  11. Coelho, P.M.B.M.; Salvador, A.; Savageau, M.A.. "Quantifying global tolerance of biochemical systems: Design implications for moiety-transfer cycles". PLoS Computational Biology 5 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-63549119474&partnerID=MN8TOARS.
    10.1371/journal.pcbi.1000319
  12. Salvador, A.; Savageau, M.A.. "Evolution of enzymes in a series is driven by dissimilar functional demands". Proceedings of the National Academy of Sciences of the United States of America 103 7 (2006): 2226-2231. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144458377&partnerID=MN8TOARS.
    10.1073/pnas.0510776103
  13. Gardner, R.; Moradas-Ferreira, P.; Salvador, A.. "Why does superoxide dismutase overexpression often increase hydrogen peroxide concentrations? An alternative explanation". Journal of Theoretical Biology 242 3 (2006): 798-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747879504&partnerID=MN8TOARS.
    10.1016/j.jtbi.2006.04.007
  14. Alves, R.; Antunes, F.; Salvador, A.. "Tools for kinetic modeling of biochemical networks". Nature Biotechnology 24 6 (2006): 667-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745075591&partnerID=MN8TOARS.
    10.1038/nbt0606-667
  15. Salvador, A.; Savageau, M.A.. "Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes". Proceedings of the National Academy of Sciences of the United States of America 100 SUPPL. 2 (2003): 14463-14468. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345060788&partnerID=MN8TOARS.
    10.1073/pnas.2335687100
  16. Gardner, R.; Salvador, A.; Moradas-Ferreira, P.. "Why does SOD overexpression sometimes enhance, sometimes decrease, hydrogen peroxide production? A minimalist explanation". Free Radical Biology and Medicine 32 12 (2002): 1351-1357. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037096203&partnerID=MN8TOARS.
    10.1016/S0891-5849(02)00861-4
  17. Salvador, A.; Sousa, J.; Pinto, R.E.. "Hydroperoxyl, superoxide and pH gradients in the mitochondrial matrix: A theoretical assessment". Free Radical Biology and Medicine 31 10 (2001): 1208-1215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035890104&partnerID=MN8TOARS.
    10.1016/S0891-5849(01)00707-9
  18. Salvador, A.. "Synergism analysis of biochemical systems. II. Tensor formulation and treatment of stoichiometric constraints". Mathematical Biosciences 163 2 (2000): 131-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034092624&partnerID=MN8TOARS.
    10.1016/S0025-5564(99)00057-7
  19. Salvador, A.. "Synergism analysis of biochemical systems. I. Conceptual framework". Mathematical Biosciences 163 2 (2000): 105-129.
    10.1016/s0025-5564(99)00056-5
  20. Antunes, F.; Salvador, A.; Marinho, H.S.; Alves, R.; Pinto, R.E.. "Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model". Free Radical Biology and Medicine 21 7 (1996): 917-943. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029908304&partnerID=MN8TOARS.
    10.1016/S0891-5849(96)00185-2
  21. Antunes, F.; Salvador, A.; Pinto, R.E.. "PHGPx and phospholipase A2/GPx: Comparative importance on the reduction of hydroperoxides in rat liver mitochondria". Free Radical Biology and Medicine 19 5 (1995): 669-677. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028991435&partnerID=MN8TOARS.
    10.1016/0891-5849(95)00040-5
  22. Salvador, A.; Antunes, F.; Pinto, R.E.. "Kinetic modelling of in vitro lipid peroxidation experiments--'low level' validation of a model of in vivo lipid peroxidation.". Free radical research 23 2 (1995): 151-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029355440&partnerID=MN8TOARS.
    10.3109/10715769509064029
Capítulo de livro
  1. Dehmer, Matthias; Emmert-Streib, Frank; Graber, Armin; Salvador, Armindo. "Preface". In Applied Statistics for Network Biology, editado por Dehmer, Matthias; Emmert-Streib, Frank; Graber, Armin; Salvador, Armindo, XVII-XVIII. Weinheim, Alemanha: Wiley-VCH Verlag GmbH & Co. KGaA, 2011.
    Publicado • 10.1016/b978-1-85573-345-9.50003-0
  2. Antunes, Fernando; Alves, Rui; Salvador, Armindo; Pinto, Ruy. "Regulação metabólica". In Bioquímica, editado por Halpern, Manuel J.. Porto, Portugal: Lidel, 1996.
    Publicado
  3. Alves, Rui; Antunes, Fernando; Salvador, Armindo; Pinto, Ruy. "Bioenergética: Termodinâmica e cinética em bioquímica". In Bioquímica, editado por Halpern, Manuel J.. Porto, Portugal: Lidel, 1996.
    Publicado
Edição de livro
  1. Salvador, Armindo. 7th International Iberian Biophysics Congress Book. Coimbra, Portugal: Portuguese and Spanish Biophysical Societies. 2021.
    Publicado
  2. Dehmer, M.; Emmert-Streib, F.; Graber, A.; Salvador, A.. Applied Statistics for Network Biology: Methods in Systems Biology. 2011.
    10.1002/9783527638079
  3. Salvador, Armindo. Applied Statistics for Network Biology. Weinheim, Alemanha: Wiley-VCH Verlag GmbH & Co. KGaA. 2011.
    Publicado • 10.1002/9783527638079
Resumo em conferência
  1. Salvador, Armindo. "~140 abstracts in national and international congresses, of which ~45 as oral presentations and 14 as invited speaker". 2022.
  2. Pais, R.; Ferreira, A.; Salvador, A.; Antunes, F.. "Kinetic Modeling of Reactive Oxygen Species in the Ancient Ocean: the Evolutionary Origin of Oxidative Stress". 2011.
    Publicado • 10.1016/j.freeradbiomed.2011.10.241
Revisão de livro
  1. Salvador, Armindo. "Book review: An Introduction to Systems Biology. Design Principles of Biological Circuits". Revisão de An Introduction to Systems Biology 215, (2008): 193-195.
    Publicado • 10.1016/j.mbs.2008.07.002

Outros

Outra produção
  1. Alexander V Peskin; Flávia C Meotti; Luiz F de Souza; Robert F Anderson; Christine C Winterbourn; Armindo Salvador. 2020. Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2. https://doi.org/10.1101/2020.05.11.087908.
    10.1101/2020.05.11.087908
  2. Gianluca Selvaggio; Pedro M. B. M. Coelho; Armindo Salvador. 2017. Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin – thioredoxin system. 1. Understanding commonalities and differences among cell types. https://doi.org/10.1101/224428.
    10.1101/224428
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/12/31 Over 40 oral presentations as invited speaker (some highlights shown)
2021/06/10 A quantitative perspective on H2O2 signaling in human cells Meeting of the European Society for Clinical Investigation 2021
European Society for Clinical Investigation (Itália)
2021/05/15 Gaining insight on H2O2 signaling through mathematical modeling XI Jornadas Nacionais de Ciências Biomédicas
Universidade da Beira Interior (Covilhã, Portugal)
2021/02/12 Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2
Instituto de Tecnologia Química e Biológica (Oeiras, Portugal)
2019/10/28 Assessing metabolic fluxes at S phase of the cell cycle through 13C-tracing of DNA deoxynucleosides 16th International Conference in Molecular Systems Biology
De La Salle University (Manila, Filipinas)
2019/10/25 Computational modeling of kinetics: from molecules to biochemical pathways G6PD deficiency: what’s new?
Universiti Kebangsaan Malaysia (Kuala Lumpur, Malásia)
2019/10/25 Biochemistry of G6PD, with a focus on human erythrocytes G6PD deficiency: what’s new?
Universiti Kebangsaan Malaysia (Kuala Lumpur, Malásia)
2019/10/10 Gaining insight on redox signaling through mathematical modeling
Instituto de Tecnologia Química e Biológica (Oeiras, Portugal)
2019/03 H2O2 signaling in the cytoplasm of eukaryotic cells: what mechanisms are viable? Workshop on Mechanobiology in Migrating Cells
Universidade de Coimbra (Coimbra, Portugal)
2017/07/26 Understanding biological variation in the cytoplasmic Peroxiredoxin/Thioredoxin system of eukaryotic cells through the systems design space methodology International Conference in Molecular Systems Biology
(Raitenhaslach, Alemanha)
2015/10/27 Connecting design and function of cellular peroxiredoxin systems through mathematical modeling and systems analysis International Symposium on Peroxiredoxins
(Seoul, Coreia do Sul)
2013 Oxidative stress and antioxidant protection antedate the great oxidation event Frontiers in Systems and Synthetic Biology
(Atlanta, Estados Unidos)
2013 Oxidative stress and antioxidant protection antedate the great oxidation event
Rice University (Houston, Estados Unidos)
2009 Naturally evolved design principles in metabolic networks International Conference on Biotechnological Solutions for Environmental Sustainability
VIT University (Vellore, Índia)
2008 Canonic design principles versus actual realizations in metabolic networks
Harvard Medical School, Department of Systems Biology (Boston, Estados Unidos)
2006 Identifying functional requirements that constrain the quantitative evolutionary design of a metabolic circuit Joint SMB-SIAM Life Science Minisymposium
(Raleigh (NC), Estados Unidos)
2004 Quantitative evolutionary design of glucose 6-phosphate dehydrogenase and glutathione reductase in human erythrocytes XXVIIth National Congress of the Spanish Society for Biochemistry and Molecular Biology
(Lleida, Espanha)
2004 Quantitative evolutionary design of glucose 6-phosphate dehydrogenase and glutathione reductase in human erythrocytes
Departament de Ciències Mèdiques Bàsiques, University of Lleida (Lleida, Espanha)
1991/04/05 The Role of Lipid Peroxidation in Cell Cycle Variability
Max-Planck-Institute für Ernahrungsphysiologie (Dortmund, Alemanha)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2005 - 2019/10/07 Analysis of metabolic heterogeneity over cell division cycle in non-synchronized yeast - a 13C based experimental-computational approach
Orientador de Inês Vasconcelos Miranda Santos (long duration due to health-related interruption))
Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/01/01 - 2017/07/31 Analysis of the Interdependence Between the Oxidation of Distinct Redox Active Sites in Human Peroxiredoxin 2
Orientador de Steve Edwin
Biotechnology (Mestrado)
VIT University, Índia
2017/01/01 - 2017/07/07 Understanding The Effects Of Glutathionylation And Functional Integration In Thiol Redox Regulation
Orientador de Keerthi Priya
Biotechnology (Mestrado)
VIT University, Índia
2011 - 2016/12/09 Active and passive defenses against oxidative stress: a computational study
Orientador de Rui Manuel Vicente Benfeitas
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2016/11/07 Seeking general principles in the design of defense systems against hydrogen peroxide
Orientador de Gianluca Selvaggio
Bioengenharia (Doutoramento)
Universidade Nova de Lisboa, Portugal
2015/01/02 - 2015/07/17 Can Peroxiredoxin-II Protect Vascular Endothelial Growth Factor Receptors from Oxidation by Hydrogen Peroxide?
Orientador de Anahita Bayani
Bioengineering (Mestrado)
Università degli Studi di Padova Scuola di Ingegneria, Itália
2014 - 2015/05/25 Analysis of output properties of the Peroxiredoxin/Thioredoxin/Thioredoxin reductase system
Orientador
Bioinformática (Mestrado)
Universidade do Minho, Portugal
2010/10/01 - 2012/06/19 Connecting design and function in moiety-transfer cycles: functional implications of product inhibition by cycled intermediates
Orientador de Marta Sofia Patrício Sá Marques
Bioinformática (Mestrado)
Universidade do Minho, Portugal
2010/10/01 - 2011/10/10 The Physiological Role of Peroxiredoxin 2 in Human Erythrocytes: A Kinetic Analysis
Orientador de Rui Manuel Benfeitas Vicente
Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010/01/01 - 2011/02/04 Estudo da Reactividade de Produtos da Peroxidação do Ácido Linoleico
Orientador de NÍDIA ALEXANDRE DUARTE MOREIRA
Química (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/10/01 - 2009/09/20 WikiModels: A RESTful Server for collaborative development of biochemical models
Orientador de Pedro Alexandre Mesquita dos Santos Martins
Engenharia Informática (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2009 Efeito da Sequestração de Intermediários na Eficácia Funcional de Ciclos Metabólicos de Transferência de Grupos
Orientador de Flávio Fortes Ramos Sousa
Química (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002 - 2009 Global Tolerance of Biochemical Systems and Its Design Implications
Coorientador de Pedro Miguel Brás Macedo Coelho
Química (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1998 - 2004 Towards Understanding the Prooxidative Mechanisms of Superoxide Dismutase - a Mathematical Approach
Orientador de Rui Gardner Costa de Oliveira
Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1996 - 2000 Development of Methodologies to Analyze and Compare Metabolic Networks- Application to Specific Classes of Metabolic Pathways
Coorientador de Rui Carlos Vaqueiro de Castro Alves
Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019/07 - Atual Organizing committee, "7th International Iberian Biophysics Congress" (2020/06/17 - 2020/06/19)
Congresso (Membro da Comissão Organizadora)
Sociedade Portuguesa de Biofísica, Portugal
2015 - Atual Founder and coordinator of the yearly international Summer School in Computational Biology (2015)
Outro (Presidente da Comissão Organizadora)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/12/01 - 2021/03/03 1-week course in Computational Biology, Ph. D. Program in Biomedicine and Experimental Biology (2021/02/22 - 2021/02/26)
Outro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/02/02 - 2020/03/15 4-day course in Computational Biology, Ph. D. Program in Biomedicine and Experimental Biology (2020/02/24 - 2020/02/28)
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/22 - 2019/05/24 Symposium co-organizer and co-chairman, “Bioinformatics and Machine Learning in Biomedicine”, at the 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019/05/22 - 2019/05/24)
Simpósio (Coorganizador)
2019/01/15 - 2019/03/15 5-day course in Computational Biology, Ph. D. Program in Biomedicine and Experimental Biology (2019/02/25 - 2019/03/01)
Outro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/06/04 - 2018/06/07 Symposium co-organizer and co-chairman, “A systems oriented perspective on key processes in redox stress and regulation”, 19th Biennial Meeting of the Society for Free Radical Research International (2018/06/04 - 2018/06/04)
Simpósio (Coorganizador)
2016/07/26 - 2017/07/28 Organizing Committee, 15th International Conference on Molecular Systems Biology (2017/07/26 - 2017/07/28)
Congresso (Membro da Comissão Organizadora)
2015/07 - 2016/06 Member of the organizing committee "5th International Iberian Biophysics Congress" (2016/06/15 - 2016/06/17)
Congresso
Sociedade Portuguesa de Biofísica, Portugal
2014/06 - 2015/01/15 Member of the Program Committee, 6th International Conference on Bioinformatics Models, Methods and Algorithms – Bioinformatics / BIOSTEC 2015, Lisbon (Portugal) (2015/01/12 - 2015/01/15)
Congresso (Membro da Comissão Científica)
INSTICC - Institute for Systems and Technologies of Information, Control and Communication, Portugal
2013/05/01 - 2013/07/23 Member of the Program Committee, "21st Annual International Conference on Intelligent Systems for Molecular Biology / 12th European Conference on Computational Biology", Berlin (Germany) (2013/07/19 - 2013/07/23)
Congresso (Outra)
International Society for Computational Biology, Estados Unidos
2012/01/01 - 2013/07/17 Member of the organizing committee "9th European Biophysics Congress", Lisbon (Portugal) (2013/07/13 - 2013/07/17)
Congresso (Membro da Comissão Organizadora)
Sociedade Portuguesa de Biofísica, Portugal
2012/06/01 - 2013/02/14 Member of the Program Committee, "4th International Conference on Bioinformatics Models, Methods and Algorithms – Bioinformatics / BIOSTEC 2013", Barcelona (Spain) (2013/02/11 - 2013/02/14)
Congresso (Membro da Comissão Científica)
INSTICC - Institute for Systems and Technologies of Information, Control and Communication, Portugal
2013 - 2013 Main organizer, PrOSysBio 2013 – International Summer School on Principles-Oriented Systems Biology (2013 - 2013)
Outro (Presidente da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012 - 2012 5-day course in Systems Biology, Ph. D. Program in Biomedicine and Experimental Biology (2012 - 2012)
Outro (Presidente da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/05 - 2011/05 12th International Conference on Molecular Systems Biology (2011/05 - 2011/05)
Congresso (Membro da Comissão Organizadora)
Universitat de Lleida, Espanha
2011 - 2011 SPBf Short Course “Nanosciences for Life” (2011/11/17 - 2011/11/19)
Oficina (workshop) (Membro da Comissão Organizadora)
Sociedade Portuguesa de Biofísica, Portugal
2009/01/01 - 2009/11/01 Short Course on Systems Biology (2009/10/30 - 2009/11/01)
Oficina (workshop) (Presidente da Comissão Organizadora)
Sociedade Portuguesa de Biofísica, Portugal
2009 - 2009 5-day course in Systems Biology, Ph. D. Program in Biomedicine and Experimental Biology (2009 - 2009)
Outro (Presidente da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2007 Member of the Programme Committee, International Conference on Molecular Systems Biology (2007 - 2007)
Conferência (Membro da Comissão Científica)
University of the Philippines Diliman, Filipinas
2007 - 2007 5-day course in kinetic modelling of biological processes, Ph. D. Program in Biomedicine and Experimental Biology (2007 - 2007)
Outro (Presidente da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2007 3-day course in bioinformatics, Ph. D. Program on Biomedicine and Experimental Biology (2007 - 2007)
Outro (Presidente da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - 2005 Member of the Programme Committee, Intelligent Systems for Molecular Biology, Detroit (U.S.A.) (2005 - 2005)
Congresso (Membro da Comissão Científica)
2004 - 2004 Member of the Programme Committee, VIII International Symposium on Biochemical Systems Theory. Lake Tahoe (USA) (2004 - 2004)
Conferência (Membro da Comissão Científica)
1997 - 1998 International Symposium on Power-Law Modelling of Biological Systems (1998 - 1998)
Simpósio (Presidente da Comissão Organizadora)
Instituto Gulbenkian de Ciência, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2019/10/07 Analysis of metabolic heterogeneity over cell division cycle in non-synchronized yeast - a 13C based experimental-computational approach
Orientador
Inês Vasconcelos Miranda Santos (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/03/29 Disentangling the function and structural modularity of the membrane arm from respiratory complex I
Arguente
Paulo Jorge Gomes de Castro (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/12/21 Network Inference of Logic-Based Ordinary Differential Equations Models
Arguente principal
David Saque Henriques (Doutoramento)
Universidade do Minho, Portugal
2016/12/09 Active and passive defenses against oxidative stress: a computational study
Orientador
Rui Manuel Vicente Benfeitas (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016/11/07 Seeking general principles in the design of defense systems against hydrogen peroxide
Orientador
Gianluca Selvaggio (Doutoramento)
Universidade Nova de Lisboa, Portugal
2016/09/16 Novel approaches for dynamic modelling of E. coli and their application in Metabolic Engineering
Arguente principal
Pedro Tiago Evangelista (Doutoramento)
Universidade do Minho, Portugal
2015/11/21 Cell functional enviromics: applications to Pichia pastoris
Arguente principal
Inês Azevedo Isidro (Doutoramento)
Universidade Nova de Lisboa, Portugal
2015/07/09 Redox state of erythrocyte peroxiredoxin 2 during oxidative stress and its effect on membrane binding
Vogal
Simone Birgit Bayer (Doutoramento)
University of Otago Christchurch, Nova Zelândia
2013 A Systems biology framework for pathway level culture media engineering: application to pichia pastoris cultures
Arguente principal
Ana Raquel Santos Ferreira (Doutoramento)
Universidade Nova de Lisboa, Portugal
2009/05/11 Automated Reverse Engineering of Metabolic Pathways from Time Series
Arguente principal
Marco António Mattos Vilela (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009 Global Tolerance of Biochemical Systems and Its Design Implications
Orientador
Pedro Miguel Brás Macedo Coelho (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 Towards Understanding the Prooxidative Mechanisms of Superoxide Dismutase - a Mathematical Approach
Orientador
Rui Gardner Costa de Oliveira (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000 Development of Methodologies to Analyze and Compare Metabolic Networks- Application to Specific Classes of Metabolic Pathways
Orientador
Rui Carlos Vaqueiro de Castro Alves (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019/10/28 - 2019/10/31 16th International Conference in Molecular Systems Biology de la Salle University, Manila, Philippines
2017/07/26 - 2017/07/28 15th International Conference on Molecular Systems Biology
2017/06/20 - 2017/06/22 6th International Iberian Biophysics Congress Castellon (Spain)
2015/06 - 2015/06 5th International Iberian Biophysics Congress Porto (Portugal)
2012 - 2012 XI Jornadas de Bioinformática Barcelona (Spain)
2011/01 - 2011/05 12th International Conference on Molecular Systems Biology Universitat de Lleida (Spain)
2009 - 2009 Jornadas de Bioinformática 2009 Lisbon (Portugal)
2000 - 2000 VI International Symposium on Biochemical Systems Theory Tenerife (Spain)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021 - Atual Antioxidants (2076-3921) MDPI
2018 - Atual iScience (2589-0042) Elsevier
2018 - Atual Free Radical Biology and Medicine
2016 - Atual eLife (2050-084X) "eLife Sciences Publications, Ltd."
2016 - Atual Free Radical Research
2016 - Atual Frontiers in Genetics
2014 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2014 - Atual Biochemical Journal (1470-8728) Portland Press
2013 - Atual PLoS ONE (1932-6203) Public Library of Science
2012 - Atual Journal of Biomolecular NMR (1573-5001) Springer-Verlag
2011 - Atual Redox Report (1351-0002) Maney Publishing
2010 - Atual Biotechnology and Bioengineering (1097-0290) Wiley (John Wiley & Sons)
2009 - Atual Journal of Theoretical Biology (1095-8541) Elsevier
2009 - Atual PLoS Computational Biology (1553-7358) Public Library of Science
2009 - Atual Molecular Cell (1097-2765) Elsevier
2008 - Atual Molecular BioSystems (1742-2051) The Royal Society of Chemistry
2008 - Atual Mathematical Biosciences (0025-5564) Elsevier
2007 - Atual The Journal of Physical Chemistry (1541-5740) American Chemical Society
2006 - Atual BioTechniques (1940-9818) Future Science Ltd
2006 - Atual FEBS Journal (1742-4658) Wiley (Blackwell Publishing)
2005 - Atual Journal of Molecular Evolution (1432-1432) Springer-Verlag
2004 - Atual Bioinformatics (1460-2059) Oxford University Press
2001 - Atual Proteins: Structure, Function, and Genetics
2000 - Atual Biotechnology Progress (1520-6033) Wiley (John Wiley & Sons)
2020/12/23 - 2021/01/19 Biomolecules (2218-273X) MDPI
2020/05/18 - 2020/06/08 Quantitative Biology (2095-4697) Springer-Verlag

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2021/05/03 - 2021/10/15 Member of Experimental Biology and Biochemistry evaluation panel for Ph.D. fellowship applications, Foundation for Science and Technology
Avaliador
Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2020/06/09 - 2020/11/09 Member of Experimental Biology and Biochemistry evaluation panel for Ph.D. fellowship applications, Foundation for Science and Technology
Membro
Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2018/07 - 2018/07 Evaluation of project proposals to "Programa de apoyo a Grupos de I+D, Universidad de la República"
Avaliador
Universidad de la República Comisión Sectorial de Investigación, Uruguai
2018 - 2018 Member of “Experimental Biology and Biochemistry” evaluation panel for Ph.D. fellowship applications, Foundation for Science and Technology
Avaliador
Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2017 - 2017 Member of “Experimental Biology and Biochemistry” evaluation panel for Ph.D. fellowship applications, Foundation for Science and Technology
Avaliador
Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2016 - 2016 Member of “Experimental Biology and Biochemistry” evaluation panel for Ph.D. and post-doctoral fellowship applications
Avaliador
Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2014 - 2014 Member of “Experimental Biology and Biochemistry” evaluation panel for post-doctoral fellowship applications
Avaliador
Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2014 - 2014 Evaluation of grant application for ERA-NET ERASYNBIO 2nd joint call for proposals, EU 7th framework programme
Avaliador

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2002 - 2003 Advice on the preparation of the call for proposals for the NEST-Pathway initiative on Synthetic Biology (NEST-2003-Path-2) European Commission Sixth Framework Programme, Bélgica

Membro de associação

Nome da associação Tipo de participação
2021/11/05 - Atual Portuguese Biophysical Society President
2021 - Atual Society for Redox Biology and Medicine
2017 - Atual Society for Free Radical Research Member
1991 - Atual American Association for the Advancement of Science Member
1991 - Atual Portuguese Biochemical Society Member
1991 - Atual Portuguese Biophysical Society Secretary
1982 - Atual Portuguese Chemical Society Member

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2018 - Atual Member of the General Assembly: miniBioqs - Associação Ciência para Todos
Consultor
miniBioqs - Associação Ciência para Todos, Portugal
2009 - Atual Member of the board of the Portuguese Biophysical Society Sociedade Portuguesa de Biofísica, Portugal
2009 - Atual Member of the Editorial Board, Journal of theoretical Biology
Membro
Elsevier BV, Países Baixos
2004 - 2004 Member of the selection Committee, Bellman Prize on Mathematical Biosciences
Membro
Elsevier BV, Países Baixos

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2017 - 2017 Assessment of application for promotion to senior lecturer University of KwaZulu-Natal, África do Sul

Tutoria

Tópico Nome do aluno
2017 - 2018 Supervision of post-doctoral fellow in Molecular Systems Biology / Redox Biology areas Hugo Louro Filipe
2012 - 2016 Supervision of post-doctoral fellow in the Molecular Systems Biology area Alessandro Bolli
2014 - 2015 Supervision of post-doctoral fellow in Molecular Systems Biology / Redox Biology areas Hugo Louro Filipe
2013 - 2015 Supervision of post-doctoral fellow in the Molecular Systems Biology field Pedro Miguel Brás Macedo Coelho
2008 - 2012 Supervision of post-doctoral fellow in Molecular Systems Biology / Redox Biology areas Chakkaravarthi Saravanan
2008 - 2012 Supervision of post-doctoral fellow in Molecular Systems Biology area Bharathi Pandurangan
Distinções

Prémio

2002 Post-doctoral fellowship SFRH/BPD/9457/2002
Fundação para a Ciência e a Tecnologia, Portugal
1997 Post-doctoral fellowship Praxis XXI/BPD/11763/97
Fundação para a Ciência e a Tecnologia, Portugal
1990 Ph. D. fellowship BD/146/90-RM
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2001 Grant to participate in the 1st Gordon Research Conference on Bioinformatics, by Chairman's invitati