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Ana Maria Ferreira de Sousa Sebastião. Completed the Título de Agregado (habilitation) in 2001 by Universidade de Lisboa Faculdade de Medicina, Doutoramento in Biochemistry and Cell Physiology in 1987 by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia and Basic Degree in Biology in 1982 by Universidade de Lisboa Faculdade de Ciências. Is Full Professor (Pharmacology and Neurosciences) at Faculdade de Medicina Universidade de Lisboa and Group Leader at Instituto de Medicina Molecular - João Lobo Antunes. Published over 200 full articles in refereed international journals. Participates and/or participated as Principal investigator in 12 compeitive projects, 4 of these from European Union Calls. Has International Collaborations with joint papers published (most as senior author) with more than 20 research groups. In her curriculum Ciência Vitae the most frequent terms in the context of scientific output are: Health Sciences - Neurosciences; Areas of Research: Neuromodulation of synaptic transmission and plasticity at the tripartite synapse; control of neuronal excitability with focus at inhibitory and excitatory hippocampal synapses. Neuromodulators coss-talk focusing on neurotrophins, adenosine, cannabinoids and other psychoactive drugs. Neuroprotection and recovery from acute and chronic neuronal insults. Adenosine receptors and adenosine transporters. Glutamate and GABA receptors and transporters. Supervision of 7 post-docs, 18 PhD Students (16 completed), 26 Master Students since 1987 up to the present. Bibliometric data (Web of Science, core collection, 4th March, 2022): h index: 49; Citations in international literature: 8168 (without self-citations: 6921); Citing Articles (without self-citations): 4802
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Ana Maria Ferreira de Sousa Sebastião
Data de nascimento
1958/03/15
Género
Feminino

Nomes de citação

  • Sebastião, AM

Identificadores de autor

Ciência ID
F112-55E8-E37E
ORCID iD
0000-0001-9030-6115

Endereços de correio eletrónico

  • anaseb@medicina.ulisboa.pt (Profissional)

Telefones

Telefone
  • 217985183 (Profissional)

Moradas

  • Faculdade de Medicina, Universidade de Lisboa; Instituto de Medicina Molecular, Universidade de Lisboa. Farmacologia e Neurociências, Edif. Egas Moniz, Piso 1B - Av. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador proficiente (C1)
Português (Idioma materno)
Formação
Grau Classificação
2001
Concluído
 Neurociências (Título de Agregado)
Universidade de Lisboa Faculdade de Medicina, Portugal
 Aprovado
1987
Concluído
 Bioquímica (Doutoramento)
Especialização em Fisiologia Celular
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Modulação da Condução Axonial e da Transmissão Neuromuscular pela Adenosina e Substâncias Relacionadas" (TESE/DISSERTAÇÃO)
 Aprovado com Distinção e Louvor
1982
Concluído
 Biologia (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudo da Função Mnéstica num grupo de doentes com Miastenia Gravis" (TESE/DISSERTAÇÃO)
 18.45
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2008 - Atual Investigador Coordenador (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
2004 - 2008 Investigador principal (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
2003 - 2008 Investigador (Investigação) Instituto de Medicina Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/02/01 - Atual Professor Catedrático (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
2004 - 2013 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
1997 - 2004 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Arquitectura, Portugal
Projetos

Bolsa

Designação Financiadores
2022/01/12 - 2025/01/11 Does context matter for drug action? Contextual dependency of the long-lasting neurobiological and antidepressant actions of psilocybin
PTDC/MED-FAR/4834/2021
Investigador responsável
Em curso
2020/11/01 - 2023/10/31 Epileptogenesis and Epilepsy Network: from genes, synapses and circuitries to pave the way for novel drugs and strategies (EpiEpiNet)
952455
Investigador responsável
Instituto de Medicina Molecular, Portugal
 EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation
Em curso
2018 - 2022/05 In the search of the synaptic mechanism operated by a novel selective antiepileptic drug
PTDC/MED-FAR/30933/2017
PTDC/MED-FAR/30933/2017
Investigador responsável
Fundação para a Ciência e a Tecnologia

N/A
Em curso
2016/01/01 - 2019 Neurologic and Psychiatric Disorders: from synapses to networks
info:eu-repo/grantAgreement/EC/H2020/692340/EU
Investigador responsável
European Commission
2016 - 2019 Synaptic, mechanisms involved in the brain cannabinoid actions and their modulation by adenosine receptors: implications for memory and mood control
PTDC/DTP-FTO/3346/2014
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2014 Modulation of GABAergic transmission in the hippocampus by adenosine
PTDC/SAU-NMC/110838/2009
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2010 Neural Regeneration and Plasticity (NEREPLAS)
COST B30 Action (EU)
Investigador
Universidade de Lisboa Faculdade de Medicina, Portugal
 European Commission
Concluído
2007/01/01 - 2008 Neurotrophins and neuronal communication: fine tuning by adenosine
info:eu-repo/grantAgreement/FCT/3599-PPCDT/82305/PT
Investigador responsável
European Commission
Concluído
2002/10/01 - 2006 Modulation of synaptic transmission in interneurones: role of adenosine
info:eu-repo/grantAgreement/FCT/POCI/37398/PT
Investigador responsável
European Commission
Concluído
1999 - 2002 Role of A2A receptors in the hippocampus: modulation of neuromodulators
SAU/14012/1998
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
1996 - 1998 ‘Nucleotides, a novel class of extracellular signalling substances in the nervous system
BMH4-CT96-0676
Investigador responsável
Goethe-Universität Frankfurt am Main, Alemanha
 European Union
Concluído
1989/01/01 - 1990/12/31 ‘In vitro evaluation of the pharmacological activity of analogues of adenine nucleotides and adenosine: structure activity requirements of ectonucleotidases’
BAP-0470P-EDP
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
 European Union
Concluído
Produções

Publicações

Artigo em conferência
  1. Valadeiro, J.; Silva, M.; Cardoso, S.; Martins, M.; Gaspar, J.; Freitas, P.P.; Sebastiao, A.M.. "Microneedles with integrated magnetoresistive sensors: A precision tool in biomedical instrumentation". 2017.
    10.1109/SAS.2017.7894041
Artigo em revista
  1. Farinha-Ferreira, Miguel; Rei, Nádia; Fonseca-Gomes, João; Miranda-Lourenço, Catarina; Serrão, Paula; Vaz, Sandra H.; Gomes, Joana I.; et al. "Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior". Neuropharmacology 214 (2022): 109155. http://dx.doi.org/10.1016/j.neuropharm.2022.109155.
    10.1016/j.neuropharm.2022.109155
  2. Ana M. Sebastião. "A maestro role of adenosine A2A receptors in GABAergic synapses stabilization during postnatal neuronal maturation". Purinergic Signalling (2022): https://doi.org/10.1007/s11302-022-09845-7.
    10.1007/s11302-022-09845-7
  3. Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; et al. "S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5". Neurobiology of Disease 163 (2022): 105603. http://dx.doi.org/10.1016/j.nbd.2021.105603.
    Acesso aberto • 10.1016/j.nbd.2021.105603
  4. Oksana K. Savchak; Nanying Wang; Miguel A. Ramos-Docampo; Paula de Dios Andres; Ana M. Sebastião; Filipa F. Ribeiro; Adam Armada-Moreira; Brigitte Städler; Sandra H. Vaz. "Manganese dioxide nanosheet-containing reactors as antioxidant support for neuroblastoma cells". Journal of Materials Chemistry B (2022): https://doi.org/10.1039/D2TB00393G.
    10.1039/D2TB00393G
  5. Santos, Sónia Sá; Moreira, João B.; Costa, Márcia; Rodrigues, Rui S.; Sebastião, Ana M.; Xapelli, Sara; Solá, Susana. "The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression". Cells 11 1 (2021): 90. http://dx.doi.org/10.3390/cells11010090.
    Acesso aberto • 10.3390/cells11010090
  6. Paulo, Sara L.; Miranda-Lourenço, Catarina; Belo, Rita F.; Rodrigues, Rui S.; Fonseca-Gomes, João; Tanqueiro, Sara R.; Geraldes, Vera; et al. "High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats". Current Issues in Molecular Biology 43 3 (2021): 2305-2319. http://dx.doi.org/10.3390/cimb43030162.
    10.3390/cimb43030162
  7. Van Zeller, Mariana; Dias, Diogo; Sebastião, Ana M.; Valente, Cláudia A.. "NLRP3 Inflammasome: A Starring Role in Amyloid-ß- and Tau-Driven Pathological Events in Alzheimer’s Disease". Journal of Alzheimer's Disease 83 3 (2021): 939-961. http://dx.doi.org/10.3233/jad-210268.
    Acesso aberto • 10.3233/jad-210268
  8. Marcelino, Helena; Carvalho, Tiago M.A.; Tomás, Joana; Teles, Francisca I.; Honório, Ana C.; Rosa, Carolina B.; Costa, Ana R.; et al. "Adenosine Inhibits Cell Proliferation Differently in Human Astrocytes and in Glioblastoma Cell Lines". Neuroscience 467 (2021): 122-133. http://dx.doi.org/10.1016/j.neuroscience.2021.05.019.
    10.1016/j.neuroscience.2021.05.019
  9. Ribeiro, Filipa F.; Ferreira, Filipa; Rodrigues, Rui S.; Soares, Rita; Pedro, Diogo M.; Duarte-Samartinho, Marta; Aroeira, Rita I.; et al. "Regulation of hippocampal postnatal and adult neurogenesis by adenosine A 2A receptor: Interaction with brain-derived neurotrophic factor". STEM CELLS 39 10 (2021): 1362-1381. http://dx.doi.org/10.1002/stem.3421.
    10.1002/stem.3421
  10. Tanqueiro, Sara R; Mouro, Francisco M; Ferreira, Catarina B; Freitas, Céline F; Fonseca-Gomes, João; Simões do Couto, Frederico; Sebastião, Ana M; Dawson, Neil; Diógenes, Maria J. "Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice". Journal of Psychopharmacology 35 6 (2021): 730-743. http://dx.doi.org/10.1177/02698811211008560.
    10.1177/02698811211008560
  11. Viana, M.B.; Martins, R.S.; Silva, M.S.C.F.; Xapelli, S.; Vaz, S.H.; Sebastião, A.M.. "Deep Brain Stimulation of the dorsal raphe abolishes serotonin 1A facilitation of AMPA receptor-mediated synaptic currents in the ventral hippocampus". Behavioural Brain Research 403 (2021): 113134. http://dx.doi.org/10.1016/j.bbr.2021.113134.
    Publicado • 10.1016/j.bbr.2021.113134
  12. Valente, Cláudia A.; Meda, Francisco J.; Carvalho, Mafalda; Sebastião, Ana M.. "A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures". Journal of Visualized Experiments 169 (2021): http://dx.doi.org/10.3791/61330.
    10.3791/61330
  13. Gomes, Joana I.; Farinha-Ferreira, Miguel; Rei, Nádia; Gonçalves-Ribeiro, Joana; Ribeiro, Joaquim A.; Sebastião, Ana M.; Vaz, Sandra H.. "Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder". Pharmacological Research 163 (2021): 105363. http://dx.doi.org/10.1016/j.phrs.2020.105363.
    Acesso aberto • Publicado • 10.1016/j.phrs.2020.105363
  14. Gomes, Joana I.; Farinha-Ferreira, Miguel; Rei, Nádia; Gonçalves-Ribeiro, Joana; Ribeiro, Joaquim A.; Sebastião, Ana M.; Vaz, Sandra H.. "Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder". Pharmacological Research 163 (2021): 105363. http://dx.doi.org/10.1016/j.phrs.2020.105363.
    Acesso aberto • 10.1016/j.phrs.2020.105363
  15. Xapelli, Sara; Soares, Rita; Ribeiro, FilipaF; Lourenço, DiogoM; Rodrigues, RuiS; Moreira, JoãoB; Sebastião, AnaM; Morais, VanessaA. "The neurosphere assay: an effective in vitro technique to study neural stem cells". Neural Regeneration Research 16 11 (2021): 2229. http://dx.doi.org/10.4103/1673-5374.310678.
    Acesso aberto • 10.4103/1673-5374.310678
  16. Paulo, Sara L.; Ribeiro-Rodrigues, Leonor; Rodrigues, Rui S.; Mateus, Joana M.; Fonseca-Gomes, João; Soares, Rita; Diógenes, Maria J.; et al. "Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-ß-Induced Alzheimer’s Disease Model". Journal of Alzheimer's disease 82 (2021): 1883-1202.
    Publicado • 10.3233/jad-201567
  17. Gomes, Ana Rita; Fernandes, Tiago G.; Vaz, Sandra H.; Silva, Teresa P.; Bekman, Evguenia P.; Xapelli, Sara; Duarte, Sofia; et al. "Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.610427.
    Acesso aberto • Publicado • 10.3389/fcell.2020.610427
  18. Robertta S. Martins; Diogo M. Rombo; Joana Gonçalves-Ribeiro; Carlos Meneses; Vladimir P. P. Borges-Martins; Joaquim A. Ribeiro; Sandra H. Vaz; et al. "Caffeine has a dual influence on NMDA receptor–mediated glutamatergic transmission at the hippocampus". Purinergic Signalling 16 4 (2020): 503-518. https://doi.org/10.1007/s11302-020-09724-z.
    Publicado • 10.1007/s11302-020-09724-z
  19. Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; Fonseca-Gomes, João; Tanqueiro, Sara R.; Belo, Rita F.; Ferreira, Catarina B.; Rei, Nádia; et al. "Challenges of BDNF-based therapies: From common to rare diseases". Pharmacological Research 162 (2020): 105281. http://dx.doi.org/10.1016/j.phrs.2020.105281.
    Publicado • 10.1016/j.phrs.2020.105281
  20. João Fonseca-Gomes; Joana A Loureiro; Sara R Tanqueiro; Francisco M Mouro; Pedro Ruivo; Tânia Carvalho; Ana M Sebastião; et al. "

    In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

    ". International Journal of Nanomedicine Volume 15 (2020): 8609-8621. https://doi.org/10.2147/IJN.S267007.
    Publicado • 10.2147/IJN.S267007
  21. Miranda-Lourenço, Catarina; Duarte, Sofia T.; Palminha, Cátia; Gaspar, Cláudia; Rodrigues, Tiago M.; Magalhães-Cardoso, Teresa; Rei, Nádia; et al. "Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling". Neurobiology of Disease 145 (2020): 105043. http://dx.doi.org/10.1016/j.nbd.2020.105043.
    Publicado • 10.1016/j.nbd.2020.105043
  22. Armada-Moreira, Adam; Thingholm, Bo; Andreassen, Kristine; Sebastião, Ana M.; Vaz, Sandra H.; Städler, Brigitte. "On the Assembly of Microreactors with Parallel Enzymatic Pathways". Advanced Biosystems 4 11 (2020): 2000132. http://dx.doi.org/10.1002/adbi.202000132.
    10.1002/adbi.202000132
  23. Adam Armada-Moreira; Joana E. Coelho; Luísa V. Lopes; Ana M. Sebastião; Brigitte Städler; Sandra H. Vaz; Armada-Moreira, Adam; et al. "Multicompartment Microreactors Prevent Excitotoxic Dysfunctions In Rat Primary Cortical Neurons". Advanced Biosystems 4 10 (2020): 2000139-2000139. https://doi.org/10.1002/adbi.202000139.
    Publicado • 10.1002/adbi.202000139
  24. Lourenço, Diogo M.; Ribeiro-Rodrigues, Leonor; Sebastião, Ana M.; Diógenes, Maria J.; Xapelli, Sara; Diogo M. Lourenço; Leonor Ribeiro-Rodrigues; et al. "Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy". International Journal of Molecular Sciences 21 19 (2020): 7309-7309. http://dx.doi.org/10.3390/ijms21197309.
    Acesso aberto • Publicado • 10.3390/ijms21197309
  25. Rodrigues, Rui S.; Paulo, Sara L.; Moreira, João B.; Tanqueiro, Sara R.; Sebastião, Ana M.; Diógenes, Maria J.; Xapelli, Sara. "Adult Neural Stem Cells as Promising Targets in Psychiatric Disorders". Stem Cells and Development 29 17 (2020): 1099-1117. http://dx.doi.org/10.1089/scd.2020.0100.
    Publicado • 10.1089/scd.2020.0100
  26. Belo, Rita F.; Martins, Margarida L. F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, Vera; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer’s Disease Pathophysiology". Frontiers in Pharmacology 11 (2020): http://dx.doi.org/10.3389/fphar.2020.00985.
    Acesso aberto • Publicado • 10.3389/fphar.2020.00985
  27. N, Rei; Rombo, D.M.; Ferreira, M.F.; Baqi, Y.; Müller, C.E.; Ribeiro, J.A.; Sebastião, A.M.; Vaz, S.H.. "Hippocampal synaptic dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis: Reversal by adenosine A2AR blockade". Neuropharmacology 171 (2020): 108106. http://dx.doi.org/10.1016/j.neuropharm.2020.108106.
    Acesso aberto • Publicado • 10.1016/j.neuropharm.2020.108106
  28. Sa de Almeida, Joana; Vargas, Mariana; Fonseca-Gomes, João; Tanqueiro, Sara Ramalho; Belo, Rita F.; Miranda-Lourenço, Catarina; Sebastião, Ana M.; Diógenes, Maria José; Pais, Teresa F.. "Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices". Frontiers in Neuroscience 14 (2020): http://dx.doi.org/10.3389/fnins.2020.00614.
    Acesso aberto • 10.3389/fnins.2020.00614
  29. Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Tomé, Ângelo R.; Cunha, Rodrigo A.; Sebastião, Ana M.; Boison, Detlev. "Role of Adenosine in Epilepsy and Seizures". Journal of Caffeine and Adenosine Research 10 2 (2020): 45-60. http://dx.doi.org/10.1089/caff.2019.0022.
    Publicado • 10.1089/caff.2019.0022
  30. Mahú, Inês; Barateiro, Andreia; Rial-Pensado, Eva; Martinéz-Sánchez, Noelia; Vaz, Sandra H.; Cal, Pedro M.S.D.; Jenkins, Benjamin; et al. "Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects". Cell Metabolism 31 6 (2020): 1120-1135.e7. http://dx.doi.org/10.1016/j.cmet.2020.04.013.
    Acesso aberto • Publicado • 10.1016/j.cmet.2020.04.013
  31. Socodato, Renato; Portugal, Camila C.; Canedo, Teresa; Rodrigues, Artur; Almeida, Tiago O.; Henriques, Joana F.; Vaz, Sandra H.; et al. "Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration". Cell Reports 31 12 (2020): 107796. http://dx.doi.org/10.1016/j.celrep.2020.107796.
    Publicado • 10.1016/j.celrep.2020.107796
  32. Soares, Rita; Ribeiro, Filipa F.; Lourenço, Diogo M.; Rodrigues, Rui S.; Moreira, João B.; Sebastião, Ana M.; Morais, Vanessa A.; Xapelli, Sara. "Isolation and Expansion of Neurospheres from Postnatal (P1−3) Mouse Neurogenic Niches". Journal of Visualized Experiments 159 (2020): http://dx.doi.org/10.3791/60822.
    Publicado • 10.3791/60822
  33. Armada-Moreira, Adam; Gomes, Joana I.; Pina, Carolina Campos; Savchak, Oksana K.; Gonçalves-Ribeiro, Joana; Rei, Nádia; Pinto, Sara; et al. "Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.00090.
    Acesso aberto • Publicado • 10.3389/fncel.2020.00090
  34. Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, Ramón; et al. "Control of glutamate release by complexes of adenosine and cannabinoid receptors". BMC Biology 18 1 (2020): http://dx.doi.org/10.1186/s12915-020-0739-0.
    10.1186/s12915-020-0739-0
  35. Helena Marcelino; Vanda C. Nogueira; Cecília R.A. Santos; Patrícia Quelhas; Tiago M.A. Carvalho; João Fonseca-Gomes; Joana Tomás; et al. "Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation". Journal of Neurochemistry (2019): https://doi.org/10.1111/jnc.14937.
    10.1111/jnc.14937
  36. Mouro, Francisco M.; Köfalvi, Attila; André, Luís A.; Baqi, Younis; Müller, Christa E.; Ribeiro, Joaquim A.; Sebastião, Ana M.. "Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism". Neuropharmacology 155 (2019): 10-21. http://dx.doi.org/10.1016/j.neuropharm.2019.05.003.
    10.1016/j.neuropharm.2019.05.003
  37. Gonçalves-Ribeiro, Joana; Pina, Carolina Campos; Sebastião, Ana Maria; Vaz, Sandra Henriques. "Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00357.
    10.3389/fncel.2019.00357
  38. Ruffolo, Gabriele; Cifelli, Pierangelo; Miranda-Lourenço, Catarina; De Felice, Eleonora; Limatola, Cristina; Sebastião, Ana M.; Diógenes, Maria J.; Aronica, Eleonora; Palma, Eleonora. "Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome". Neuroscience (2019): http://dx.doi.org/10.1016/j.neuroscience.2019.06.015.
    10.1016/j.neuroscience.2019.06.015
  39. Rodrigues, Rui; Lourenço, Diogo; Paulo, Sara; Mateus, Joana; Ferreira, Miguel; Mouro, Francisco; Moreira, João; et al. "Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology". Molecules 24 7 (2019): 1350. http://dx.doi.org/10.3390/molecules24071350.
    10.3390/molecules24071350
  40. Fonseca-Gomes, João; Jerónimo-Santos, André; Lesnikova, Angelina; Casarotto, Plinio; Castrén, Eero; Sebastião, Ana M.; Diógenes, Maria J.. "TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins". Frontiers in Molecular Neuroscience 12 (2019): http://dx.doi.org/10.3389/fnmol.2019.00004.
    10.3389/fnmol.2019.00004
  41. Castanheira, Lígia; Ferreira, Miguel F.; Sebastião, Ana M.; Telles-Correia, Diogo. "Anxiety Assessment in Pre-clinical Tests and in Clinical Trials: A Critical Review". Current Topics in Medicinal Chemistry 18 19 (2018): 1656-1676. http://dx.doi.org/10.2174/1568026618666181115102518.
    10.2174/1568026618666181115102518
  42. Ferreira, Miguel F.; Castanheira, Lígia; Sebastião, Ana M.; Telles-Correia, Diogo. "Depression Assessment in Clinical Trials and Pre-clinical Tests: A Critical Review". Current Topics in Medicinal Chemistry 18 19 (2018): 1677-1703. http://dx.doi.org/10.2174/1568026618666181115095920.
    10.2174/1568026618666181115095920
  43. Ferreira, Filipa Fiel; Ribeiro, Filipa F.; Rodrigues, Rui S.; Sebastião, Ana Maria; Xapelli, Sara. "Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis". Frontiers in Cellular Neuroscience 12 (2018): http://dx.doi.org/10.3389/fncel.2018.00441.
    10.3389/fncel.2018.00441
  44. Mouro, Francisco M; Rombo, Diogo M; Dias, Raquel B; Ribeiro, Joaquim A; Sebastião, Ana M. "Adenosine A2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons". British Journal of Pharmacology 175 23 (2018): 4386-4397. http://dx.doi.org/10.1111/bph.14497.
    10.1111/bph.14497
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  172. Sebastiäo, A.M.; De Mendonça, A.; Moreira, T.; Alexandre Ribeiro, J.. "Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on reoxygenation". Journal of Neuroscience 21 21 (2001): 8564-8571. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035503016&partnerID=MN8TOARS.
  173. Sebastião, A.M.; Cunha, R.A.; De Mendonça, A.; Ribeiro, J.A.. "Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats". British Journal of Pharmacology 131 8 (2000): 1629-1634. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034531574&partnerID=MN8TOARS.
    10.1038/sj.bjp.0703736
  174. Sebastião, A.M.; Ribeiro, J.A.. "Fine-tuning neuromodulation by adenosine". Trends in Pharmacological Sciences 21 9 (2000): 341-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034284203&partnerID=MN8TOARS.
    10.1016/S0165-6147(00)01517-0
  175. De Mendonça, A.; Sebastião, A.M.; Ribeiro, J.A.. "Adenosine: Does it have a neuroprotective role after all?". Brain Research Reviews 33 2-3 (2000): 258-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033823084&partnerID=MN8TOARS.
    10.1016/S0165-0173(00)00033-3
  176. Sebastião, A.M.; Macedo, M.P.; Ribeiro, J.A.. "Tonic activation of A(2A) adenosine receptors unmasks, and of A 1 receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus". British Journal of Pharmacology 129 2 (2000): 374-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033984885&partnerID=MN8TOARS.
  177. Sebastiao, A.M.; Cunha, R.A.; Cascalheira, J.F.; Ribeiro, J.A.. "Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases". Progress in Brain Research 120 (1999): 183-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032881106&partnerID=MN8TOARS.
  178. Costenla, A.R.; De Mendonca, A.; Sebastiao, A.; Ribeiro, J.A.. "An adenosine analogue inhibits NMDA receptor-mediated responses in bipolar cells of the rat retina [1]". Experimental Eye Research 68 3 (1999): 367-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033026536&partnerID=MN8TOARS.
    10.1006/exer.1998.0645
  179. Cascalheira, J.F.; Sebastião, A.M.. "Adenosine A1 receptor activation inhibits basal accumulation of inositol phosphates in rat hippocampus". Pharmacology and Toxicology 82 4 (1998): 189-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031596913&partnerID=MN8TOARS.
  180. Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A.. "Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors". Journal of Neuroscience 18 6 (1998): 1987-1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032521330&partnerID=MN8TOARS.
  181. Lorenzen, A.; Sebastião, A.M.; Sellink, A.; Vogt, H.; Schwabe, U.; Ribeiro, J.A.; Ijzerman, A.P.. "Biological activities of N6, C8-disubstituted adenosine derivates as partial agonists a rat brain adenosine A1 receptors". European Journal of Pharmacology 334 2-3 (1997): 299-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030609091&partnerID=MN8TOARS.
    10.1016/S0014-2999(97)01193-X
  182. Lobo, M.G.B.; Oliveira, D.G.; Sebastião, A.M.; Ribeiro, J.A.. "On the high affinity of 8-cyclohexylcaffeine for the presynaptic inhibitory adenosine receptor present in rat motor nerve terminals". Pharmacology and Toxicology 80 6 (1997): 295-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-8544255575&partnerID=MN8TOARS.
    10.1111/j.1600-0773.1997.tb01977.x
  183. Afonso, F.; Sebastião, A.M.; Pinho, M.S.; Fernandes, P.; Ribeiro, J.A.; Mata, L.R.; Gulbenkian, S.. "Calcitonin gene-related peptide in the hamster seminal vesicle and coagulating gland: An immunohistochemical, autoradiographical, and pharmacological study". Peptides 17 7 (1996): 1189-1195. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029995741&partnerID=MN8TOARS.
    10.1016/S0196-9781(96)00183-0
  184. Lucchi, R.; Latini, S.; De Mendonça, A.; Sebastião, A.M.; Ribeiro, J.A.. "Adenosine by activating A1 receptors prevents GABA(A)-mediated actions during hypoxia in the rat hippocampus". Brain Research 732 1-2 (1996): 261-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030565024&partnerID=MN8TOARS.
    10.1016/0006-8993(96)00748-2
  185. Cunha, R.A.; Correia-de-Sá, P.; Sebastião, A.M.; Ribeiro, J.A.. "Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides". British Journal of Pharmacology 119 2 (1996): 253-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029844019&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1996.tb15979.x
  186. Sebastião, A.M.; Ribeiro, J.A.. "Adenosine A2 receptor-mediated excitatory actions on the nervous system". Progress in Neurobiology 48 3 (1996): 167-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029665969&partnerID=MN8TOARS.
    10.1016/0301-0082(95)00035-6
  187. Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sa, P.; Sebastiao, A.M.. "Purinergic regulation of acetylcholine release". Progress in Brain Research 109 (1996): 231-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030474316&partnerID=MN8TOARS.
  188. Cunha, R.A.; Johansson, B.; Constantino, M.D.; Sebastião, A.M.; Fredholm, B.B.. "Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 353 3 (1996): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029670460&partnerID=MN8TOARS.
  189. Cunha, R.A.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M.. "Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices". Journal of Neurochemistry 67 5 (1996): 2180-2187. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029819083&partnerID=MN8TOARS.
  190. Ribeiro, J.A.; De Mendonça, A.; Correia-de-Sá, P.; Cunha, R.A.; Sebastião, A.M.. "Purinoceptors and synaptic plasticity". Drug Development Research 39 3-4 (1996): 353-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030435849&partnerID=MN8TOARS.
  191. Cunha, R.A.; Johansson, B.; Fredholm, B.B.; Alexandre Ribeiro, J.; Sebastião, A.M.. "Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus". Neuroscience Letters 196 1-2 (1995): 41-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028984662&partnerID=MN8TOARS.
    10.1016/0304-3940(95)11833-I
  192. Cunha, R.A.; Constantino, M.D.; Sebastiao, A.M.; Ribeiro, J.A.. "Modification of A1 and A(2a) adenosine receptor binding in aged striatum, hippocampus and cortex of the rat". NeuroReport 6 11 (1995): 1583-1588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028983106&partnerID=MN8TOARS.
  193. Oliveira, J.C.; Constantino, M.D.; Sebastião, A.M.; Ribeiro, J.A.. "Ascorbate/Fe3+-induced peroxidation and inhibition of the binding of A1 adenosine receptor ligands in rat brain membranes". Neurochemistry International 26 3 (1995): 263-268. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028988407&partnerID=MN8TOARS.
    10.1016/0197-0186(94)00124-D
  194. De Mendonca, A.; Sebastiao, A.M.; Ribeiro, J.A.. "Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurones by adenosine A1 receptor activation". NeuroReport 6 8 (1995): 1097-1100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029078855&partnerID=MN8TOARS.
  195. Pinho, M.S.; Sebastia˜o, A.M.; Rodrigues, G.; Barroso, C.P.; Ribeiro, J.A.; Mata, L.R.; Gulbenkian, S.. "Vasoactive intestinal peptide in the hamster seminal vesicle: Distribution, binding sites and possible functions". Neuroscience 59 4 (1994): 1083-1091. http://dx.doi.org/10.1016/0306-4522(94)90307-7.
    10.1016/0306-4522(94)90307-7
  196. Cunha, R.A.; Ribeiro, J.A.; Sebastiao, A.M.. "Purinergic modulation of the evoked release of [3H]Acetylcholine from the hippocampus and cerebral cortex of the rat: Role of the ectonucleotidases". European Journal of Neuroscience 6 1 (1994): 33-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028031731&partnerID=MN8TOARS.
    10.1111/j.1460-9568.1994.tb00245.x
  197. Cunha, R.A.; Johansson, B.; van der Ploeg, I.; Sebastião, A.M.; Alexandre Ribeiro, J.; Fredholm, B.B.. "Evidence for functionally important adenosine A2a receptors in the rat hippocampus". Brain Research 649 1-2 (1994): 208-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028342730&partnerID=MN8TOARS.
    10.1016/0006-8993(94)91066-9
  198. Ribeiro, J.A.; Sebastião, A.M.. "Further evidence for adenosine A3 receptors". Trends in Pharmacological Sciences 15 1 (1994): http://www.scopus.com/inward/record.url?eid=2-s2.0-0028091154&partnerID=MN8TOARS.
    10.1016/0165-6147(94)90123-6
  199. Cunha, R.A.; Milusheva, E.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M.. "Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus". Journal of Neurochemistry 63 1 (1994): 207-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028241057&partnerID=MN8TOARS.
    10.1046/j.1471-4159.1994.63010207.x
  200. Oliveira, J.C.; Sebastiao, A.M.; Ribeiro, J.A.. "On the high affinity binding site for [3G]-1,3-dipropyl-8-cyclopentylxanthine in frog brain membranes". British Journal of Pharmacology 109 2 (1993): 518-523. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027199971&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1993.tb13600.x
  201. Cunha, R.A.; Sebastiao, A.M.. "Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog". Pflugers Archiv European Journal of Physiology 424 5-6 (1993): 503-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027250345&partnerID=MN8TOARS.
    10.1007/BF00374914
  202. Cascalheira, J.F.; Sebastiao, A.M.. "Adenine nucleotide analogues, including ¿-phosphate-substituted analogues, are metabolised extracellularly in innervated frog sartorius muscle". European Journal of Pharmacology 222 1 (1992): 49-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026493732&partnerID=MN8TOARS.
    10.1016/0014-2999(92)90462-D
  203. Sebastião, A.M.; Ribeiro, J.A.. "Evidence for the presence of excitatory A2 adenosine receptors in the rat hippocampus". Neuroscience Letters 138 1 (1992): 41-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026532594&partnerID=MN8TOARS.
    10.1016/0304-3940(92)90467-L
  204. Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat". Journal of Neurochemistry 59 2 (1992): 657-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026660013&partnerID=MN8TOARS.
    10.1111/j.1471-4159.1992.tb09420.x
  205. Cunha, R.A.; Sebastiao, A.M.. "Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog". European Journal of Pharmacology 197 1 (1991): 83-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025829211&partnerID=MN8TOARS.
    10.1016/0014-2999(91)90368-Z
  206. Correia-de-Sa, P.; Sebastiao, A.M.; Ribeiro, J.A.. "Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat". British Journal of Pharmacology 103 2 (1991): 1614-1620. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025906606&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1991.tb09836.x
  207. Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Relative contribution of nerve endings to the release of adenine nucleotides in the innervated frog sartorius muscle". Nucleosides and Nucleotides 10 5 (1991): 1189-1190. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026070005&partnerID=MN8TOARS.
    10.1080/07328319108047271
  208. Oliveira, J.C.; Sebastiao, A.M.; Ribeiro, J.A.. "Solubilized rat brain adenosine receptors have two binding sites for 1,3-dipropyl-8-cyclopentylxanthine". Nucleosides and Nucleotides 10 5 (1991): 1135-1137. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026002891&partnerID=MN8TOARS.
    10.1111/j.1471-4159.1991.tb08275.x
  209. Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Blockade of AMP degradation allows the quantification of adenine nucleotides released by nerve stimulation in the innervated frog sartorius muscle". European Journal of Pharmacology 183 5 (1990): 1684-1685. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025106547&partnerID=MN8TOARS.
    10.1016/0014-2999(90)91979-L
  210. Lobo, M.G.B.; Sebastiao, A.M.; Ribeiro, J.A.. "Effects of adenosine analogues, dibutyryl cyclic AMP and forskolin on 22Na uptake by synaptosomes". European Journal of Pharmacology 183 2 (1990): 478-479. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025329316&partnerID=MN8TOARS.
    10.1016/0014-2999(90)93371-V
  211. Ribeiro, J.A.; Sebastiao, A.M.. "The excitatory presynaptic effect of lithium at the frog neuromuscular junction is prevented by adenosine receptor agonists". European Journal of Pharmacology 183 5 (1990): 1740-1741. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025004088&partnerID=MN8TOARS.
    10.1016/0014-2999(90)92047-M
  212. Sebastiao, A.M.; Ribeiro, J.A.. "Interactions between adenosine and phorbol esters or lithium at the frog neuromuscular junction". British Journal of Pharmacology 100 1 (1990): 55-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025373483&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1990.tb12051.x
  213. Delicado, E.G.; Rodrigues, A.; Sen, R.P.; Sebastiao, A.M.; Ribeiro, J.A.; Miras-Portugal, M.T.. "Effect of 5'-(N-Ethylcarboxamido)adenosine on adenosine transport in cultured chromaffin cells". Journal of Neurochemistry 54 6 (1990): 1941-1946. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025371455&partnerID=MN8TOARS.
    10.1111/j.1471-4159.1990.tb04895.x
  214. Sebastiao, A.M.; Stone, T.W.; Ribeiro, J.A.. "The inhibitory adenosine receptor at the neuromuscular junction and hippocampus of the rat: Antagonism by 1,3,8-substituted xanthines". British Journal of Pharmacology 101 2 (1990): 453-459. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025121405&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1990.tb12729.x
  215. Sebastiao, A.M.; Ribeiro, J.A.. "1,3,8- and 1,3,7-substituted xanthines: Relative potency as adenosine receptor antagonists at the frog neuromuscular junction". British Journal of Pharmacology 96 1 (1989): 211-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024597570&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1989.tb11802.x
  216. Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A.. "Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography". Chromatographia 28 11-12 (1989): 610-612. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001249211&partnerID=MN8TOARS.
    10.1007/BF02260687
  217. Ribeiro, J.A.; Sebastião, A.M.. "Is inhibition of neurotransmitter release mediated by A3 receptors? Subtypes of adenosine receptors". Trends in Pharmacological Sciences 9 8 (1988): 279-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024064891&partnerID=MN8TOARS.
    10.1016/0165-6147(88)90007-7
  218. Simoes, A.P.; Oliveira, P.C.; Sebastiao, A.M.; Ribeiro, J.A.. "N6-Cyclohexyladenosine inhibits veratridine-stimulated 22Na uptake by rat brain synaptosomes". Journal of Neurochemistry 50 3 (1988): 899-903. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023818215&partnerID=MN8TOARS.
    10.1111/j.1471-4159.1988.tb02997.x
  219. Sebastiao, A.M.; Ribeiro, J.A.. "On the adenosine receptor and adenosine inactivation at the rat diaphragm neuromuscular junction". British Journal of Pharmacology 94 1 (1988): 109-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023893622&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1988.tb11505.x
  220. Ribeiro, J.A.; Sebastiao, A.M.. "On the role, inactivation and origin of endogenous adenosine at the frog neuromuscular junction". Journal of Physiology Vol. 384 (1987): 571-585. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023162244&partnerID=MN8TOARS.
    10.1113/jphysiol.1987.sp016470
  221. Ribeiro, J.A.; Sebastião, A.M.. "Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor". Progress in Neurobiology 26 3 (1986): 179-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022591269&partnerID=MN8TOARS.
    10.1016/0301-0082(86)90015-8
  222. Ribeiro, J.A.; Sebastiao, A.M.. "Inhibitory effects of forskolin and papaverine on nerve conduction partially blocked by tetrodotoxin in the frog sciatic nerve". British Journal of Pharmacology 85 1 (1985): 309-313. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021916852&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1985.tb08861.x
  223. Ribeiro, J.A.; Sebastiao, A.M.. "On the type of receptor involved in the inhibitory action of adenosine at the neuromuscular junction". British Journal of Pharmacology 84 4 (1985): 911-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021908720&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1985.tb17385.x
  224. Sebastiao, A.M.; Ribeiro, J.A.. "Enhancement of transmission at the frog neuromuscular junction by adenosine deaminase: Evidence for an inhibitory role of endogenous adenosine on neuromuscular transmission". Neuroscience Letters 62 2 (1985): 267-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022350145&partnerID=MN8TOARS.
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  225. Ribeiro, J.A.; Sebastiao, A.M.. "Enhancement of tetrodotoxin-induced axonal blockade by adenosine, adenosine analogues, dibutyryl cyclic AMP and methylxanthines in the frog sciatic nerve". British Journal of Pharmacology 83 2 (1984): 485-492. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021162425&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1984.tb16511.x
  226. Ribeiro, J.A.; Sebastiao, A.M.. "Antagonism of tetrodotoxin- and procaine-induced axonal blockade by adenine nucleotides in the frog sciatic nerve". British Journal of Pharmacology 81 2 (1984): 277-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021364988&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1984.tb10075.x
Capítulo de livro
  1. Vaz, Sandra H.; Pinto, Sara; Sebastião, Ana M.; Brites, Dora. "Astrocytes in Amyotrophic Lateral Sclerosis". In Amyotrophic Lateral Sclerosis, 35-54. Exon Publications, 2021.
    10.36255/exonpublications.amyotrophiclateralsclerosis.astrocytes.2021
  2. Diógenes, M.J.; Ribeiro, J.A.; Sebastião, A.M.. "Adenosine A2A receptors and neurotrophic factors: Relevance for parkinson's disease". 2015.
    10.1007/978-3-319-20273-0_4
  3. Sebastião, AM; Rombo, D.M.; Ribeiro, JA; Sebastião, A.M.; Ribeiro, J.A.. "Adenosine receptor modulation of GABAergic transmission". In Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects, editado por Ramkumar V; Paes de Carvalho R, 193-220. Nova Science Publishers, 2015.
  4. Sebastião, A.M.; Cristóvão-Ferreira, S.; Ribeiro, J.A.. "Downstream pathways of adenosine". 2013.
    10.1007/978-1-4614-3903-5_7
  5. Barroso, S.; Sebastião, A.M.. "Research possibilities for pre-graduate students". 2012.
    10.1007/978-1-4614-0568-9_2
  6. Pedata, F.; Pugliese, A.M.; Sebastião, A.M.; Ribeiro, J.A.. "Adenosine A3 receptor signaling in the central nervous system". 2010.
    10.1007/978-90-481-3144-0_9
  7. Sebastião, Ana M.; Ribeiro, Joaquim A.. "Adenosine Receptors and the Central Nervous System". In Adenosine Receptors in Health and Disease, 471-534. Springer Berlin Heidelberg, 2009.
    10.1007/978-3-540-89615-9_16
  8. Ribeiro, JA; Sebastião, AM. "Purinergic modulation of neurotransmitter release in the peripheral and central nervous systems". In Presynaptic Regulation of Neurotransmitter release, A Handbook, editado por Feigenbaum J; Hanani M, 451-495. Freund, London, Reino Unido: Freund, 1991.

Outros

Outra produção
  1. Bibliometric data. Web of knowledge, Core Collection, March 4, 2022): h index: 49; Citations in international literature: 8168 (without self-citations: 6921); Citing Articles (without self-citations): 4802. 2021. Sebastião, AM.
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
1987 - Atual Supervision of 7 post-docs, 18 PhD Students (16 completed), 26 Master Students since 1987 up to the present
Orientador de Several

Arbitragem científica em conferência

Nome da conferência Local da conferência
2006 - 2008 Federation of European Neuroscience Societies Forum (FENS Forum 2008) Swiss Society for Neuroscience
2002 - 2004 Federation of European Pharmacological Societies Biannual Meeting (EPHAR 2004) Sociedade Portuguesa de Farmacologia

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2001 - Atual Journal of Neurochemistry (1471-4159) Function: Handling Editor

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2021 - 2021 Expert evaluator of Noora Puhakka merits for a Tenure Track position as Assistant Professor. Academy of Finland
2021 - 2021 Expert evaluator of the call for Support of Young Investigators, Clube Brasileiro de Purinas
2020 - 2020 Research Project Evaluator for the Austrian Science Fund
2020 - 2020 Expert evaluator Research Foundation, Flanders – Basic (SBO) projects – FWO
2020 - 2020 Expert Evaluator of the Oregon Tax Checkoff for Alzheimer’s Research Fund and Oregon Partnership for Alzheimer’s Research (OPAR)
2018 - 2020 Member of the International Scientific Committee for the 2018 and 2020 AriSLA Call for Projects on ALS
Avaliador
 Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica, Itália Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica
2017 - 2020 Evaluation of Scientific Projects for the Medical Research Council
2017 - 2019 Member of the Evaluating pannel of Scientific Projects for the Academy of Finland in 2017, 2018 and 2019, by invitation of the Research Council for Biosciences, Health and Environment
Avaliador
 Suomen Akatemia, Finlândia Suomen Akatemia
2014 - 2019 Evaluator of Scientific Projects for the Czech Science Foundation
2018 - 2018 Chair of the Evaluation pannel of Era-Net Neuron call on "Transnational Research Projects on Mental Disorders"
Avaliador
 European Union, Bélgica
2017 - 2017 Member of the evaluation committee of the tenth call for proposals of NEURON: RESEARCH PROJECTS ON SYNAPTIC DYSFUNCTION IN DISORDERS OF THE CENTRAL NERVOUS SYSTEM, by invitation of ERA-NET Neuron
Avaliador
 European Union, Bélgica
2014 - 2014 Evaluator of scientific projects for the Danish Council for Independent Research

Membro de associação

Nome da associação Tipo de participação
2004 - 2008 President of Sociedade Portuguesa de Neurociências President
2001 - 2004 President of Sociedade Portuguesa de Farmacologia President

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2007 - Atual Director of the PhD Programme of Integrative Neurosciences (supported by FCT) (Start 2015) Member of the Scientific Board of the Master and PhD Programmes in Neuroscience, Faculty of Medicine, University of Lisbon (Start 2007) Member of the Scientific Board of the Master and PhD Programmes in Cognitive Sciences, University of Lisbon (Start 2008) Member of the Coordinating Board of the Biomedical Engineering Integrated Master Course, University of Lisbon (start 2007)
2015 - 2018 Director of the Mind Brain College of the University of Lisbon
2002 - 2004 Member of the Organizing Committee of the Federation of European Neuroscience Societies Scientific Forum (FENS 2004) Federation of European Neuroscience Societies, Bélgica
Distinções

Título

2011 Académico Titular da Academia Portuguesa de Medicina

Outra distinção

2008 Member (elected) of the DANA Alliance for Brain Initiatives
European Dana Alliance for the Brain, Reino Unido