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João Nuno Sereno de Almeida Moreira. Completed the Doutoramento in Ph D in Pharmacy, area of expertise Pharmaceutical Technology/Biotechnology in 2002/03/18 by Faculty of Pharmacy, University of Coimbra, Mestrado in Master on Cellular Biology in 1995/04/28 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and Licenciatura in Degree on Pharmaceutical Sciences in 1991/09/06 by Faculty of Pharmacy, University of Coimbra. Attends the Título de Agregado in Habilitation on Pharmaceutical Technology (Biotechnology) by Faculty of Pharmacy, University of Coimbra since 2014/01/16. Is Co-founder of TREAT U, SA in TREAT U, SA, Assistant Professor in Faculty of Pharmacy, University of Coimbra, Researcher in Center for Neurosciences and Cell Biology (CNC), University of Coimbra and Group Leader in Center for Neurosciences and Cell Biology (CNC), University of Coimbra. Published 68 articles in journals. Has published in high impact journals such Nano Today (IF: 16,907), Biomaterials (IF: 10,273), Journal of Controlled Release (IF: 7.261), ACS Nano (IF: 12.033), Cancer Treatment Reviews (IF: 8.332), Accounts of Chemical Research (IF: 20.323) or Advanced Drug Delivery Reviews (IF: 15.038). Has 13 section(s) of books. Has 8 patent(s) registered (3 granted in US and 2 in Europe and licensed no TREAT U, SA). Has lectured over 145 oral communications by invitation, among PhD and Master courses, as well as in national and international meetings (including the advanced course on Principles and Practice in Drug Development (at MIT, Boston, USA). One of the technologies developed by JNM¿s group has been awarded with the Orphan Drug Designation for the treatment of human malignant mesothelioma, by EMA (2017) and FDA (2018). Organized 11 event(s). Participated in 25 event(s). Supervised 6 post-doctoral fellows, 10 PhD thesis(es) e co-supervised 7. Supervised 9 MSc dissertation(s) e co-supervised 1. Supervised 43 work(s) of course completion of LSc/BSc. Has received 13 awards and/or honors. Participates and/or participated as Principal investigator in 18 project(s) and Researcher in 16 project(s). (2008-2014) Expert reviewer of PhD and Post-Doc fellowships and (2015) Coordinator (area of Biomedicine, PhD fellowships) for the Portuguese Foundation for Science and Technology (FCT) and grants from international funding agencies (2018 - Dutch Cancer Society; 2017 - Israel Science Foundation; 2010, 2011, 2013, 2018-2020 - EuroNanoMed ERA-Net Consortium; 2009 - Netherlands Organization for Scientific Research; 2012, 2014 - French National Research Agency; 2014 - Italian Foundation for Research on Amyotrophic Lateral Sclerosis; 2009 - Netherlands Organization for Scientific Research). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Health-Related Biotechnology and Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Pharmacology and pharmacy. In their professional activities interacted with 438 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Health Sciences - Biomaterials; Health Sciences - Pharmacology and Pharmacological Sciences; Biochemistry Engineering and Biotechnology; Health Sciences - Oncology and Biopathology of Organs and Systems; .
Identificação

Identificação pessoal

Nome completo
João Nuno Sereno de Almeida Moreira

Nomes de citação

  • Moreira, João Nuno

Identificadores de autor

Ciência ID
EF1B-FA3D-0787
ORCID iD
0000-0003-3449-0522

Endereços de correio eletrónico

  • jmoreira@ff.uc.pt (Profissional)

Websites

  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1222&idgrp=1253&IdGrupo=1221&IdSeccao=&hash=39&lg=1 (Profissional)
  • https://www.linkedin.com/in/jn-moreira-1a966624/ (Profissional)
  • https://www.cibb.uc.pt/research_it_3.html (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
Formação
Grau Classificação
2007/03/19 - 2030/12/31
Em curso
Assistant Professor with Tenure (Outros)
Faculty of Pharmacy, University of Coimbra, Portugal
2014/01/16 - 2030
Em curso
Habilitation on Pharmaceutical Technology (Biotechnology) (Título de Agregado)
Especialização em Professor Agregado em Ciências Farmacêuticas, na especialidade de Tecnologia Farmacêutica
Faculty of Pharmacy, University of Coimbra, Portugal
"Sistemas de base nanotecnológica em oncologia: desafios e oportunidades" (TESE/DISSERTAÇÃO)
Approved by unanimity
2002/03/18
Concluído
Ph D in Pharmacy, area of expertise Pharmaceutical Technology/Biotechnology (Doutoramento)
Faculty of Pharmacy, University of Coimbra, Portugal
"Targeting Stealth Liposomes to Human Small Cell Lung Cancer" (TESE/DISSERTAÇÃO)
Praise and Distinction by unanimit
1996 - 2000
Concluído
Visiting graduate student (Outros)
Faculty of Medicine, University of Alberta, Canadá
1995/04/28
Concluído
Master on Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Characterization of carboplati-containing liposomes coated with O-palmitoylpullulan" (TESE/DISSERTAÇÃO)
Very Good (highest classification)
1991/09/06
Concluído
Degree on Pharmaceutical Sciences (Licenciatura)
Faculty of Pharmacy, University of Coimbra, Portugal
"n/a" (TESE/DISSERTAÇÃO)
15,3 (out of 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2005/09/01 - Atual Investigador (Investigação) Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
2011 - 2018 Investigador principal (carreira) (Investigação) Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2002/03/19 - Atual Professor Auxiliar (Docente Universitário) Faculty of Pharmacy, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1995/04/29 - 2002/03/17 Assistente (Docente Universitário) Faculty of Pharmacy, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1992/10/29 - 1995/04/28 Assistente Estagiário (Docente Universitário) Faculty of Pharmacy, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1991/11/08 - 1992/10/28 Monitor (Docente Universitário) Faculty of Pharmacy, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2010/01/29 - Atual Co-founder of TREAT U, SA TREAT U, SA, Portugal
2005 - Atual Group Leader (Tumor Microenvironment and Targeted Therapies) Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
Produções

Publicações

Artigo em conferência
  1. Costa, Cláudia; Cunha, Sara; Peixoto, Andreia; Moreira, João Nuno; Sousa Lobo, José; Silva, Ana. "Application of the quality-by-design (QbD) approach to improve the nose-to-brain delivery of diazepam-loaded nanostructured lipid carriers (NLC)". 2020.
    10.3390/iecp2020-08658
  2. Chiara, Brignole; Bensa, Veronica; Zotto, Genny Del; Bruno, Silvia; Fonseca, Nuno A; Cruz, Ana F; Paolo, Daniela Di; et al. "Nucleolin: A novel cell surface protein for neuroblastoma targeted therapy". Trabalho apresentado em AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, 2019.
    10.1158/1535-7163.targ-19-a101
  3. Fonseca, Nuno A.; Moura, Vera; Colelli, Fabiana; Pesce, Daniela; Signorino, Giacomo; Focareta, Laura; Fucci, Alessandra; et al. "In vivo targeting of mesothelioma’s molecular signature with nanoparticle functionalized with nucleolin-binding peptide". Trabalho apresentado em 110th Annual Meeting of the American Association for Cancer Research, Atlanta, 2019.
    Publicado • 10.1158/1538-7445.am2019-2994
  4. Cruz, Ana F.; Fonseca, Nuno A.; Gonçalves, Nélio; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Differential effect of liposomal C6-ceramide/doxorubicin targeted to nucleolin and conventional combinations against triple negative breast cancer stem cells". Trabalho apresentado em 10th Annual Meeting of the American Association for Cancer Research, Atlanta, 2019.
    Publicado • 10.1158/1538-7445.am2019-3622
  5. Marta Isabel Pereira; João T. Barata; Ana Bela Sarmento-Ribeiro; Moreira, João Nuno. "The prognostic impact of nucleolin overexpression in hematologic neoplasms.". Trabalho apresentado em Annual Meeting of the Portuguese Society of Hematology, Vilamoura, 2019.
    Publicado
  6. Fonseca, Nuno A.; Moura, Vera; Colelli, Fabiana; Pesce, Daniela; Cardile, Francesco; Pisano, Claudio; Simões, Sérgio; Moreira, João Nuno. "Targeting nucleolin with doxorubicin-containing nanoparticle induces a significant tumor growth inhibition in an orthotopic animal model of standard of care-resistant mesothelioma". Trabalho apresentado em AACR Annual Meeting 2017, Washington DC, 2017.
    Publicado • 10.1158/1538-7445.am2017-5155
  7. Cruz, Ana Filipa; Fonseca, Nuno A.; Sampaio, Susana F.; Moura, Vera; Almeida, Ramiro D.; Simões, Sérgio; Moreira, João Nuno. "Synergistic cytotoxicity of targeted liposomes containing doxorubicin and C6-ceramide against nucleolin-overexpressing ovarian cancer cells is supported by the downregulation of the Akt pathway". Trabalho apresentado em AACR Annual Meeting 2017, Washington DC, 2017.
    Publicado • 10.1158/1538-7445.am2017-2194
  8. Balça-Silva, Joana; do Carmo, Anália; Sarmento-Ribeiro, A. B.; Moura-Neto, Vivaldo; Lopes, Maria Celeste; Moreira, João Nuno. "Nucleolin overexpression in glioblastoma stem-like cells enables targeted intracellular delivery and improves cytotoxicity". Trabalho apresentado em : 41st FEBS Congress - Molecular and Systems Biology for a Better Life, Ephesus, 2016.
    10.1111/febs.2016.283.issue-S1 /react-text react-text: 53 /react-text react-text: 54 /react-text react-text: 55
  9. Valério-Fernandes, Ângela; Fonseca, Nuno A.; Moura, V.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Simões, S.; Moreira, João Nuno. "Targeting Nucleolin in Lung Cancer: an emerging strategy to overcome stroma-mediated anti-VEGF resistance". Trabalho apresentado em 23rd Biennial Congress of the European Association for Cancer Research (EACR-23): From Basic Research to Personalised Cancer Treatment, Munich, 2014.
    Publicado
  10. Valério-Fernandes, Ângela; Fonseca, Nuno; Moura, Vera; Ladeirinha, Ana; Ferreira, Teresa; Alarcão, Ana; Carvalho, Lina; Simões, Sérgio; Moreira, João Nuno. "Targeting nucleolin: A potential strategy to overcome stroma-mediated bevacizumab resistance in lung cancer.". Trabalho apresentado em American Association for Cancer Research (AACR) Annual Meeting 2014: Harnessing Breakthroughs - Targeting Cures, San Diego CA, 2014.
    Publicado • 10.1158/1538-7445.am2014-3003
  11. Gregório, A.C.; Fonseca, N.A.; Moura, V.; Domingues, G.; Lacerda, M.; Figueiredo, P.; Simões, S.; Dias, S.; Moreira, João Nuno. "Targeting cell-surface nucleolin in metastatic breast cancer.". Trabalho apresentado em EACR23 23rd Biennial Congress of the European Association for Cancer Research, Munich, 2014.
    Publicado
  12. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria M E; Soares, Raquel; Simões, Sérgio; Moreira, João. "A novel targeted triggered release nanoparticle against cancer cells of diverse histological origin.". Trabalho apresentado em AACR Annual Meeting 2013, Washington DC, 2013.
    Publicado • 10.1158/1538-7445.am2013-4521
  13. Moreira, João Nuno; N. Monteiro; A. Martins; R. Pires; S. Faria; Fonseca, Nuno A.; R. L. Reis; N. M. Neves. "Immobilization of bioactive factor-loaded liposomes at the surface of electrospun nanofibers targeting tissue engineering strategies". Porto, 2013.
    Publicado
  14. Monteiro N. S.; Martins A.; Ribeiro D.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Induction of Human Mesenchymal Stem Cells Osteogenesis by Bioactive Agent-Releasing Liposomes". Trabalho apresentado em Term Stem, Guimarães, 2012.
    Publicado
  15. Carvalho, Lina; Alarcão, A; Ladeirinha, Ana; D'Aguiar, MJ; Ferreira, T; Moura, Vera; Lacerda, Manuela; et al. "Nuclear and cytoplasmic expression of nucleolin depends on accurate validity". Trabalho apresentado em 24th European Congress of Pathology., Prague, 2012.
    Publicado
  16. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, M. Luisa; Cruz, M. Eugenia M.; Soares, Raquel; de Lima, M. Conceicao Pedroso; Simoes, Sergio; Moreira, Joao Nuno. "Limiting tumor invasion with multifunctional nanoparticle targeting the tumor microenvironment.". Trabalho apresentado em AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, San Francisco, CA, 2011.
    10.1158/1535-7163.targ-11-c233
  17. Figueiredo, Sara; Moreira, João Nuno; Geraldes, CF; Aime, Silvio; Terreno, Enzo. "Gd-loaded yeast cell wall particles: an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Torino, 2011.
  18. Gomes-da-Silva, L.C.; Ramalho, JS; Pedroso de Lima, M.C.; Simões, Sérgio; Moreira, João Nuno. "Targeted Gene Silencing for Cancer Treatment.". Trabalho apresentado em 16th International Charles Heidelberger Symposium on Cancer Research, Coimbra, 2010.
    Publicado
  19. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, M. Luisa; Cruz, ME; Maria C. Pedroso de Lima; Simões, Sérgio; Moreira, João Nuno. "Targeting non-viral vectors to tumor cells and the tumor micronvironment.". Trabalho apresentado em The 16th International Charles Heidelberger Symposium on Cancer Research, Coimbra, 2010.
    Publicado
  20. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria Luisa; Cruz, Maria Eugénia; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João Nuno. "Targeted delivery of therapeutics to tumor cells and the tumor microenvironment". Trabalho apresentado em AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, 2009.
    Publicado • 10.1158/1535-7163.TARG-09-A129
  21. Carvalho, JFS; Cruz Silva, M.M.; Moreira, João Nuno; Simões, Sérgio; Sa´ e Melo, M. Luisa. "Cytotoxic epoxysterols: chemoenzymatic synthesis, biological evaluation and SAR.". Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, Barcelona, 2009.
    Publicado
  22. Santos, A.; Pereira, J. P.; Simões, S.; Moreira, João Nuno. "SiRNA mediated downregulation of Bcl-2 in small cell lung cancer cell lines - impact on protein level and cell viability". Trabalho apresentado em 20th Meeting of the European-Association-for-Cancer-Research, Lyon, 2008.
    Publicado
  23. Moura, V.; Simões, S.; Pedroso de Lima, M.C.; Moreira, João Nuno. "Novel approaches to breast cancer therapy – simultaneous targeting to tumor and endothelial cells". Trabalho apresentado em 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Geneva, 2008.
    Publicado • 10.1016/S1359-6349(08)71990-6
  24. Pinto, A. C.; Moreira, João Nuno; Simões, S.. "In vitro evaluation of combined effects of conventional and new cytotoxic agents against a hormone-refractory prostate cancer (HRPC) cell line.". Trabalho apresentado em 7th World Basic Urological Research Congress - Joint Meeting of the European Society for Urological Research and the Society for Basic Urologic Research, Dublin, 2007.
    Publicado
  25. Fonseca, Nuno A.; Moreira, João Nuno; Mendonça, L.; Cabrita, A.; Paiva, A.; Lopes, M. T. C.; Pedroso De Lima, M.C.; et al. "Targeted delivery of antisense oligonucleotides to human T-leukemia cells mediated by novel liposomal formulations: evaluation of in vitro and in vivo anti-tumoral activity". Trabalho apresentado em 9th Annual Meeting of the American Society of Gene Therapy, Baltimore, 2006.
    Publicado • https://doi.org/10.1016/j.ymthe.2006.08.1059
  26. Moreira, João Nuno; Gaspar, Rogério; Allen, T. M.. "In vivo targeting of stealth liposomes against human small cell lung cancer.". Trabalho apresentado em 8th Liposome Research Days Conference., Berlin, 2003.
    Publicado
Artigo em revista
  1. Cláudia Pina Costa; Sandra Barreiro; João Nuno Moreira; Renata Silva; Hugo Almeida; José Manuel Sousa Lobo; Ana Catarina Silva. "In Vitro Studies on Nasal Formulations of Nanostructured Lipid Carriers (NLC) and Solid Lipid Nanoparticles (SLN)". Pharmaceuticals 14 8 (2021): 711-711. https://doi.org/10.3390/ph14080711.
    10.3390/ph14080711
  2. Costa, C.P.; Cunha, S.; Moreira, J. N.; Silva, R.; Gil-Martins, E.; Silva, V.; Azevedo, L.; et al. "Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: toxicological effect of surface charge on human neuronal cells". International Journal of Pharmaceutics (2021): 120933. http://dx.doi.org/10.1016/j.ijpharm.2021.120933.
    10.1016/j.ijpharm.2021.120933
  3. Brignole, Chiara; Bensa, Veronica; Fonseca, Nuno A.; Del Zotto, Genny; Bruno, Silvia; Cruz, Ana F.; Malaguti, Fabiana; et al. "Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy". Journal of Experimental & Clinical Cancer Research 40 1 (2021): http://dx.doi.org/10.1186/s13046-021-01993-9.
    10.1186/s13046-021-01993-9
  4. Ana Filipa Fernandes da Cruz; Mariana Biscaia Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al. "The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway". Cancers (2021): https://www.mdpi.com/2072-6694/13/12/3052.
    10.3390/cancers13123052
  5. Rui Lopes; Kevin Shi; Nuno A. Fonseca; Adelina Gama; José S. Ramalho; Luís Almeida; Vera Moura; et al. "Modelling the impact of nucleolin expression level on the activity of F3 peptide-targeted pH-sensitive pegylated liposomes containing doxorubicin". Drug Delivery and Translational Research (2021): https://doi.org/10.1007/s13346-021-00972-z.
    10.1007/s13346-021-00972-z
  6. Fonseca, Nuno A.; Gregório, Ana C.; Mendes, Vera M.; Lopes, Rui; Abreu, Teresa; Simões, Sérgio; Moreira, João Nuno. "GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure". Nano Today 37 (2021): 101095. http://dx.doi.org/10.1016/j.nantod.2021.101095.
    10.1016/j.nantod.2021.101095
  7. Cláudia Pina Costa; João Nuno Moreira; José Manuel Sousa Lobo; Ana Catarina Silva. "Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies". Acta Pharmaceutica Sinica B (2021): https://doi.org/10.1016/j.apsb.2021.02.012.
    10.1016/j.apsb.2021.02.012
  8. Carvalho, Laura Sofia; Gonçalves, Nélio; Fonseca, Nuno André; Moreira, João Nuno. "Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis". Pharmaceuticals 14 1 (2021): 60. http://dx.doi.org/10.3390/ph14010060.
    10.3390/ph14010060
  9. Costa, Cláudia Pina; Cunha, Sara; Peixoto, Andreia F.; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana Catarina. "Application of the Quality-by-Design (QbD) Approach to Improve the Nose-to-Brain Delivery of Diazepam-Loaded Nanostructured Lipid Carriers (NLCs)". Proceedings 78 1 (2020): 40. http://dx.doi.org/10.3390/iecp2020-08658.
    10.3390/iecp2020-08658
  10. Cunha, S.; Costa, C.P.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A. C.. "Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review". Nanomedicine: Nanotechnology, Biology and Medicine (2020): 102206. http://dx.doi.org/10.1016/j.nano.2020.102206.
    No prelo • 10.1016/j.nano.2020.102206
  11. Abreu, Teresa R.; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno (EF1B-FA3D-0787). "Current challenges and emerging opportunities of CAR-T cell therapies". Journal of Controlled Release 319 (2020): 246-261. http://dx.doi.org/10.1016/j.jconrel.2019.12.047.
    10.1016/j.jconrel.2019.12.047
  12. Romano, Sofia; Fonseca, Nuno; Simões, Sérgio; Gonçalves, João; Moreira, João Nuno. "Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands". Drug Discovery Today 24 10 (2019): 1985-2001. http://dx.doi.org/10.1016/j.drudis.2019.06.018.
    Publicado • 10.1016/j.drudis.2019.06.018
  13. Costa, C.; Moreira, J.N.; Amaral, M.H.; Sousa Lobo, J.M.; Silva, A.C.. "Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis". Journal of Controlled Release 295 (2019): 187-200. http://dx.doi.org/10.1016/j.jconrel.2018.12.049.
    Publicado • 10.1016/j.jconrel.2018.12.049
  14. Balça-Silva, Joana; do Carmo, Anália; Tão, Hermínio; Rebelo, Olinda; Barbosa, Marcos; Moura-Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela; Lopes, Maria Celeste; Moreira, João Nuno. "Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity". Experimental Cell Research 370 1 (2018): 68-77. http://dx.doi.org/10.1016/j.yexcr.2018.06.005.
    Publicado • 10.1016/j.yexcr.2018.06.005
  15. Romano, Sofia; Moura, Vera; Simões, Sérgio; Moreira, João Nuno; Gonçalves, João. "Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-25816-8.
    10.1038/s41598-018-25816-8
  16. Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno. "Meeting the needs of breast cancer: A nucleolin's perspective". Critical Reviews in Oncology/Hematology 125 (2018): 89-101. http://dx.doi.org/10.1016/j.critrevonc.2018.03.008.
    10.1016/j.critrevonc.2018.03.008
  17. Zupancic, Eva; Curato, Caterina; Kim, Jung-Seok; Yeini, Eilam; Porat, Ziv; Viana, Ana S.; Globerson-Levin, Anat; et al. "Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer". Nanomedicine: Nanotechnology, Biology and Medicine 14 3 (2018): 835-847. http://dx.doi.org/10.1016/j.nano.2017.12.011.
    10.1016/j.nano.2017.12.011
  18. Cruz, Ana Filipa; Fonseca, Nuno Andre; Moura, Vera; Simoes, Sergio; Moreira, Joao Nuno. "Targeting Cancer Stem Cells and Non-Stem Cancer Cells: The Potential of Lipid- Based Nanoparticles". Current Pharmaceutical Design 23 43 (2018): 6563-6572. http://dx.doi.org/10.2174/1381612823666171115105252.
    10.2174/1381612823666171115105252
  19. Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno; Ana C. Gregório; et al. "Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer". Pathology & Oncology Research 24 4 (2017): 701-716. http://dx.doi.org/10.1007/s12253-017-0307-2.
    10.1007/s12253-017-0307-2
  20. Zupancic, Eva; Curato, Caterina; Paisana, Maria; Rodrigues, Catarina; Porat, Ziv; Viana, Ana S.; Moreira, João N.; et al. "Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming". Journal of Controlled Release 258 (2017): 182-195. http://dx.doi.org/10.1016/j.jconrel.2017.05.014.
    10.1016/j.jconrel.2017.05.014
  21. Fonseca, Nuno A.; Cruz, Ana Filipa; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "The cancer stem cell phenotype as a determinant factor of the heterotypic nature of breast tumors". Critical Reviews in Oncology/Hematology 113 (2017): 111-121. http://dx.doi.org/10.1016/j.critrevonc.2017.03.016.
    10.1016/j.critrevonc.2017.03.016
  22. Gregório, Ana C.; Fonseca, Nuno A.; Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno. "Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model". PLOS ONE 11 11 (2016): e0165817. http://dx.doi.org/10.1371/journal.pone.0165817.
    10.1371/journal.pone.0165817
  23. Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al. "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype". Biomaterials 82 (2016): 124-137. http://dx.doi.org/10.1016/j.biomaterials.2015.12.021.
    Publicado • 10.1016/j.biomaterials.2015.12.021
  24. Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al. "Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles". Data in Brief 6 (2016): 700-705. http://dx.doi.org/10.1016/j.dib.2016.01.017.
    10.1016/j.dib.2016.01.017
  25. Nelson Monteiro; Albino Martins; Ricardo A. Pires; Susana Faria; Nuno A. Fonseca; João N. Moreira; Rui L. Reis; et al. "Dual release of a hydrophilic and a hydrophobic osteogenic factor from a single liposome". RSC Advances 6 115 (2016): 114599-114612. https://doi.org/10.1039/C6RA21623D.
    10.1039/C6RA21623D
  26. J. Goncalves; L. Graça; Moreira, João Nuno; I. V. Figueiredo; F. Scappaticci; J. Eurico Fonseca; F. Magro; et al. "Development of e-learning platform about biologic drugs with focus on monoclonal antibodies". International Journal of Clinical Pharmacy 38 2 (2016): 519-520.
    Publicado
  27. Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Gregório, Ana C.; Simões, Sérgio; Moreira, João Nuno. "Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination". Biomaterials 69 (2015): 76-88. http://dx.doi.org/10.1016/j.biomaterials.2015.08.007.
    Publicado • 10.1016/j.biomaterials.2015.08.007
  28. Zupancic, Eva; Peres, Carina; I Matos, Ana; Lopes, Joao; N Moreira, Joao; S Gaspar, Rogerio; F Florindo, Helena. "Translational Peptide-associated Nanosystems: Promising Role as Cancer Vaccines". Current Topics in Medicinal Chemistry 16 3 (2015): 291-313. http://dx.doi.org/10.2174/1568026615666150701115508.
    10.2174/1568026615666150701115508
  29. Monteiro, Nelson; Martins, Margarida; Martins, Albino; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.. "Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin". Acta Biomaterialia 18 (2015): 196-205. http://dx.doi.org/10.1016/j.actbio.2015.02.018.
    10.1016/j.actbio.2015.02.018
  30. Fonseca, Nuno A.; Gomes-da-Silva, Lígia C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination". Journal of Controlled Release 196 (2014): 122-131. http://dx.doi.org/10.1016/j.jconrel.2014.09.024.
    10.1016/j.jconrel.2014.09.024
  31. Monteiro, Nelson; Ribeiro, Diana; Martins, Albino; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.. "Instructive Nanofibrous Scaffold Comprising Runt-Related Transcription Factor 2 Gene Delivery for Bone Tissue Engineering". ACS Nano 8 8 (2014): 8082-8094. http://dx.doi.org/10.1021/nn5021049.
    Publicado • 10.1021/nn5021049
  32. Fonseca, Nuno A.; Gregório, Ana C.; Valério-Fernandes, Ângela; Simões, Sérgio; Moreira, João N.. "Bridging cancer biology and the patients' needs with nanotechnology-based approaches". Cancer Treatment Reviews 40 5 (2014): 626-635. http://dx.doi.org/10.1016/j.ctrv.2014.02.002.
    Publicado • 10.1016/j.ctrv.2014.02.002
  33. Zupancic, Eva; Silva, JoanaM; Videira, Mafalda A.; Moreira, João N.; Florindo, Helena F.. "Development of a Novel Nanoparticle-based Therapeutic Vaccine for Breast Cancer Immunotherapy". Procedia in Vaccinology 8 (2014): 62-67. http://dx.doi.org/10.1016/j.provac.2014.07.011.
    Publicado • 10.1016/j.provac.2014.07.011
  34. Monteiro, Nelson; Martins, Albino; Pires, Ricardo; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.. "Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering". Biomater. Sci. 2 9 (2014): 1195-1209. http://dx.doi.org/10.1039/c4bm00069b.
    Publicado • 10.1039/c4bm00069b
  35. Gomes-da-Silva, Lígia Catarina; Simões, Sérgio; Moreira, João Nuno; Gomes-da-Silva, L.C.; Simões, S.; Moreira, J.N.. "Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology". Cellular and Molecular Life Sciences 71 8 (2013): 1417-1438. http://dx.doi.org/10.1007/s00018-013-1502-2.
    Publicado • 10.1007/s00018-013-1502-2
  36. Gomes-da-Silva, Lígia C.; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N.. "Impact of anti-PLK1 siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells". European Journal of Pharmaceutics and Biopharmaceutics 85 3 (2013): 356-364. http://dx.doi.org/10.1016/j.ejpb.2013.04.007.
    Publicado • 10.1016/j.ejpb.2013.04.007
  37. Monteiro, Nelson; Martins, Albino; Ribeiro, Diana; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.; Moreira, João Nuno. "On the use of dexamethasone-loaded liposomes to induce the osteogenic differentiation of human mesenchymal stem cells". Journal of Tissue Engineering and Regenerative Medicine 9 9 (2013): 1056-1066. http://dx.doi.org/10.1002/term.1817.
    Publicado • 10.1002/term.1817
  38. Gomes-da-Silva, Lígia C; Fernández, Yolanda; Abasolo, Ibane; Schwartz, Simo; Ramalho, José S; Pedroso de Lima, Maria C; Simões, Sérgio; Moreira, João N. "Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform". Nanomedicine 8 9 (2013): 1397-1413. http://dx.doi.org/10.2217/nnm.12.174.
    Publicado • 10.2217/nnm.12.174
  39. Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Moreira, João N; Pereira de Almeida, Luís; Pedroso de Lima, Maria C. "Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: a promising system for glioblastoma treatment". Molecular Therapy - Nucleic Acids 2 (2013): e100. http://dx.doi.org/10.1038/mtna.2013.30.
    Publicado • 10.1038/mtna.2013.30
  40. Gomes, C.P.; Gomes-da-Silva, L.C.; Ramalho, J.S.; de Lima, M.C.P.; Simões, S.; Moreira, J.N.. "Impact of PLK-1 silencing on endothelial cells and cancer cells of diverse histological origin". Current Gene Therapy 13 3 (2013): 189-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878633310&partnerID=MN8TOARS.
    10.2174/1566523211313030004
  41. Figueiredo, S.; Cutrin, J.C.; Rizzitelli, S.; De Luca, E.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E.. "MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent". Molecular Imaging and Biology 15 3 (2013): 307-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727777&partnerID=MN8TOARS.
    10.1007/s11307-012-0603-x
  42. Gomes-da-Silva, Lígia C.; Santos, Adriana O.; Bimbo, Luís M.; Moura, Vera; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N.. "Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment". International Journal of Pharmaceutics 434 1-2 (2012): 9-19. http://dx.doi.org/10.1016/j.ijpharm.2012.05.018.
    Publicado • 10.1016/j.ijpharm.2012.05.018
  43. Gomes-da-Silva, Lígia C.; Fonseca, Nuno A.; Moura, Vera; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N.. "Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges". Accounts of Chemical Research 45 7 (2012): 1163-1171. http://dx.doi.org/10.1021/ar300048p.
    Publicado • 10.1021/ar300048p
  44. Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio. "Development, Characterization and In Vitro Evaluation of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations". Journal of Nanoscience and Nanotechnology 12 3 (2012): 2891-2900. http://dx.doi.org/10.1166/jnn.2012.5703.
    10.1166/jnn.2012.5703
  45. Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR". Journal of Medicinal Chemistry 54 18 (2011): 6375-6393. http://dx.doi.org/10.1021/jm200803d.
    10.1021/jm200803d
  46. Botelho, M.F.; De Lima, J.J.P.; Dormehl, I.C.; Fontes Baganha, M.; Gomes, C.M.; Santos, A.C.; Moreira, J.N.; Kilian, E.. "[Visualization of deep lung lymphatic network using radioliposomes]. [Article in Portuguese]". Revista Portuguesa de Pneumologia (English Edition) 17 5 (2011): 240. http://dx.doi.org/10.1016/j.rppnen.2011.09.002.
    10.1016/j.rppnen.2011.09.002
  47. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria E. M.; Soares, Raquel; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N.. "Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer". Breast Cancer Research and Treatment 133 1 (2011): 61-73. http://dx.doi.org/10.1007/s10549-011-1688-7.
    Publicado • 10.1007/s10549-011-1688-7
  48. Figueiredo, Sara; Moreira, João Nuno; Geraldes, Carlos F. G. C.; Rizzitelli, Silvia; Aime, Silvio; Terreno, Enzo. "Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging". Chemical Communications 47 38 (2011): 10635. http://dx.doi.org/10.1039/c1cc14019a.
    Publicado • 10.1039/c1cc14019a
  49. Figueiredo, S.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E.. "Supramolecular protamine/Gd-loaded liposomes adducts as relaxometric protease responsive probes". Bioorganic and Medicinal Chemistry 19 3 (2011): 1131-1135. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551487375&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.07.057
  50. Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Liposomal imatinib-mitoxantrone combination: Formulation development and therapeutic evaluation in an animal model of prostate cancer". The Prostate 71 1 (2010): 81-90. http://dx.doi.org/10.1002/pros.21224.
    10.1002/pros.21224
  51. Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis". Journal of Medicinal Chemistry 53 21 (2010): 7632-7638. http://dx.doi.org/10.1021/jm1007769.
    Publicado • 10.1021/jm1007769
  52. Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N.. "In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability". Brazilian Journal of Medical and Biological Research 43 10 (2010): 1001-1009. http://dx.doi.org/10.1590/s0100-879x2010007500099.
    Publicado • 10.1590/s0100-879x2010007500099
  53. Mendonça, Liliana S.; Moreira, João N.; de Lima, Maria C. Pedroso; Simões, Sérgio. "Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment". Biotechnology and Bioengineering 107 5 (2010): 884-893. http://dx.doi.org/10.1002/bit.22858.
    Publicado • 10.1002/bit.22858
  54. Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio. "Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy". Cancer Chemotherapy and Pharmacology 67 2 (2010): 275-284. http://dx.doi.org/10.1007/s00280-010-1315-z.
    Publicado • 10.1007/s00280-010-1315-z
  55. Santos, Adriana O.; da Silva, Lígia C. Gomes; Bimbo, Luís M.; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N.. "Design of peptide-targeted liposomes containing nucleic acids". Biochimica et Biophysica Acta (BBA) - Biomembranes 1798 3 (2010): 433-441. http://dx.doi.org/10.1016/j.bbamem.2009.12.001.
    Publicado • 10.1016/j.bbamem.2009.12.001
  56. Mendonc¸a, Liliana S.; Firmino, Filipe; Moreira, João N.; Pedroso de Lima, Maria C.; Simões, Se´rgio. "Transferrin Receptor-Targeted Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment". Bioconjugate Chemistry 21 1 (2010): 157-168. http://dx.doi.org/10.1021/bc9004365.
    Publicado • 10.1021/bc9004365
  57. Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P.. "Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid". Bioorganic and Medicinal Chemistry 18 12 (2010): 4385-4396. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.04.085
  58. Carvalho, Joa~o F. S.; Cruz Silva, M. Manuel; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols". Journal of Medicinal Chemistry 52 13 (2009): 4007-4019. http://dx.doi.org/10.1021/jm9003973.
    Publicado • 10.1021/jm9003973
  59. Cardoso, Ana; Trabulo, Sara; Moreira, João Nuno; Düzgünes, Nejat; de Lima, Maria C. Pedroso. "Targeted Lipoplexes for siRNA Delivery". Methods in Enzymology (2009): 267-287. http://dx.doi.org/10.1016/s0076-6879(09)65014-x.
    10.1016/s0076-6879(09)65014-x
  60. Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner". Cancer Chemotherapy and Pharmacology 64 3 (2008): 445-454. http://dx.doi.org/10.1007/s00280-008-0892-6.
    Publicado • 10.1007/s00280-008-0892-6
  61. Santos, A.; Sarmento-Ribeiro, A. B.; de Lima, M. C. Pedroso; Simões, S.; Moreira, J. N.. "Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer". Cytometry Part A 73A 12 (2008): 1165-1172. http://dx.doi.org/10.1002/cyto.a.20634.
    Publicado • 10.1002/cyto.a.20634
  62. João Nuno Moreira; A. Santos; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões; Moreira, J.N.; Santos, A.; et al. "Non-viral lipid-based nanoparticles for cancer systemic gene silencing". Journal of Nanoscience and Nanotechnology 8 5 (2008): 2187-2204. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS.
    Publicado • 10.1166/jnn.2008.319
  63. Moreira, João Nuno; Santos, Adriana; Simões, Sérgio. "Bcl-2-Targeted Antisense Therapy (Oblimersen Sodium): Towards Clinical Reality". Reviews on Recent Clinical Trials 1 3 (2006): 217-235. http://dx.doi.org/10.2174/157488706778250050.
    Publicado • 10.2174/157488706778250050
  64. FONSECA, C; MOREIRA, J; CIUDAD, C; PEDROSODELIMA, M; SIMOES, S. "Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells". European Journal of Pharmaceutics and Biopharmaceutics 59 2 (2005): 359-366. http://dx.doi.org/10.1016/j.ejpb.2004.08.012.
    Publicado • 10.1016/j.ejpb.2004.08.012
  65. Simões, S; João Nuno Moreira; Nejat Düzgünes N; Maria C. Pedroso de Lima. "On the formulation of pH-sensitive liposomes with long circulation times". Advanced Drug Delivery Reviews 56 7 (2004): 947-965. http://dx.doi.org/10.1016/j.addr.2003.10.038.
    10.1016/j.addr.2003.10.038
  66. Moreira, J.N.; Gaspar, R.. "Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NCI-H82 variant small cell lung cancer". Brazilian Journal of Medical and Biological Research 37 8 (2004): 1185-1192. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444282289&partnerID=MN8TOARS.
    Publicado • 10.1590/s0100-879x2004000800008
  67. Moreira, J.N.; Simões, S.. "Technology evaluation: LErafAON, NeoPharm". Current Opinion in Molecular Therapeutics 5 5 (2003): 547-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142154204&partnerID=MN8TOARS.
    Publicado
  68. Moreira, J.N.; Ishida, T.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Ishida, Tatsuhiro; Gaspar, Rogério; Allen, Theresa M.. "Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity". Pharmaceutical Research 19 3 (2002): 265-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036200912&partnerID=MN8TOARS.
    Publicado • 10.1023/A:1014434732752
  69. Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D.. "Adventures in targeting". Journal of Liposome Research 12 1-2 (2002): 5-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036331129&partnerID=MN8TOARS.
    10.1081/LPR-120004771
  70. Moreira, João N.; Gaspar, Rogério; Allen, Theresa M.; Moreira, J.N.; Gaspar, R.; Allen, T.M.. "Targeting Stealth liposomes in a murine model of human small cell lung cancer". Biochimica et Biophysica Acta (BBA) - Biomembranes 1515 2 (2001): 167-176. http://dx.doi.org/10.1016/s0005-2736(01)00411-4.
    Publicado • 10.1016/s0005-2736(01)00411-4
  71. Moreira, J.N.; Hansen, C.B.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Hansen, Christian B.; Gaspar, Rogério; Allen, Theresa M.. "A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer". Biochimica et Biophysica Acta - Biomembranes 1514 2 (2001): 303-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035479680&partnerID=MN8TOARS.
    Publicado • 10.1016/S0005-2736(01)00386-8
  72. Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Madeira, V.M.C.; Costa, M.L.. "Carboplatin liposomes coated with O-palmitoylpullulan: In vitro characterization". International Journal of Pharmaceutics 147 2 (1997): 153-164. http://dx.doi.org/10.1016/s0378-5173(96)04808-9.
    Publicado • 10.1016/s0378-5173(96)04808-9
  73. Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Costa, M.L.; Moreira, J. N.; Almeida, L. M.; Geraldes, C. F.; Costa, M. L.. "Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoylpullulan)". Journal of Materials Science: Materials in Medicine 7 5 (1996): 301-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030151980&partnerID=MN8TOARS.
    Publicado • 10.1007/bf00058571
  74. Veiga, F.; Simoes, S.; Moreira, J.N.; Sousa, A.. "Characterization of the in vitro dissolution of some commercial sustained release theophylline dosage forms". Drug Development and Industrial Pharmacy 20 8 (1994): 1471-1483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028335187&partnerID=MN8TOARS.
Artigo em revista (magazine)
  1. Moreira, João Nuno. "A Nanotecnologia e o desenvolvimento de novos medicamentos", Mundo Farmacêutico, 2011
  2. Ferreira, F.; Moreira, João Nuno; Prazeres, D. M.; Rocha, I.; Rodrigues, L.. "Bioteams: do Laboratório para o Mercado", Boletim Biotecnologia - Sociedade Portuguesa de Biotecnologia, 2011
  3. Antunes, A.; Botelho, M. F.; Gomes, C. M.; Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.. "Desenvolvimento de lipossomas com afinidade para áreas miocárdicas isquémicas", Ser Saúde, 2007
  4. Moreira, João Nuno. "Os lipossomas na terapia antitumoral: de esferas fosfolipídicas à aplicação clínica", Mundo Médico, 2000
Capítulo de livro
  1. Abreu, Teresa R.; Biscaia, Mariana; Gonçalves, Nélio; Fonseca, Nuno A.; Moreira, João Nuno. "In Vitro and In Vivo Tumor Models for the Evaluation of Anticancer Nanoparticles". In Advances in Experimental Medicine and Biology, 271-299. Springer International Publishing, 2021.
    10.1007/978-3-030-58174-9_12
  2. Ribeiro, Rita; Abreu, Teresa Raquel; Silva, Ana Catarina; Gonçalves, João; Moreira, João Nuno. "Insights on the Formulation of Recombinant Proteins". In Current Applications of Pharmaceutical Biotechnology. Advances in Biochemical Engineering/Biotechnology, 23-54. Springer International Publishing, 2020.
    10.1007/10_2019_119
  3. Silva, Ana Catarina; Costa, Cládia Pina; Almeida, Hugo; Moreira, João Nuno; Sousa Lobo, José Manuel. "Hormones, Blood Products, and Therapeutic Enzymes". In Current Applications of Pharmaceutical Biotechnology. Advances in Biochemical Engineering/Biotechnology., 115-153. Springer International Publishing, 2020.
    Publicado • 10.1007/10_2019_111
  4. Abreu, T. R.; Biscaia, M.; Gonçalves, N.; Fonseca, Nuno A.; Moreira, João Nuno. "In vitro and in vivo tumor models for the evaluation of anticancer nanoparticles". In Biomedicine for Cancer Therapy, editado por Hélder Santos; Flavia Fontana. Springer Nature, 2020.
    No prelo
  5. Silva, Ana Catarina; Moreira, João Nuno; Sousa Lobo, José Manuel. "Hematopoietic Growth Factors". In Encyclopedia of Molecular Pharmacology, 1-5. Springer International Publishing, 2020.
    10.1007/978-3-030-21573-6_72-1
  6. Cruz, Ana Filipa; Fonseca, Nuno A.; Gregório, Ana C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Moving Liposome Technology from the Bench to the Oncological Patient: Towards Performance-by-Design". In Particles and Nanoparticles in Pharmaceutical Products, editado por Merkus H.; Meesters G.; Oostra W., 171-211. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-94174-5_4
  7. Fonseca, Nuno A.; Lopes, Rui M.; Cruz, Ana F.; Gregório, Ana C.; Valério-Fernandes, Ângela; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Lipid-Based Nanosystems for the Delivery of siRNA: Challenges and Trends". In Handbook of Nanomaterials for Cancer Theranostics, editado por João Conde, 495-515. Elsevier, 2018.
    Publicado • 10.1016/b978-0-12-813339-2.00016-5
  8. Lopes, R.M.; Fonseca, N.A.; Cruz, A.F.; Gregório, A.C.; Valério-Fernandes, Â.; Moura, V.; Simões, S.; Moreira, J.N.. "Advances on nucleic acid delivery with nonviral vectors". In Bioinspired Materials for Medical Applications, editado por Lígia Rodrigues, 403-426. Elsevier, 2017.
    Publicado • 10.1016/b978-0-08-100741-9.00014-0
  9. Gomes-da-Silva, L.C.; Sérgio Simões; Moreira, João Nuno. "The use of liposomes for the systemic delivery of RNAi therapeutics aiming at cancer treatment". In Liposomal delivery systems - Advances and challenges, editado por Ryan De Vooght-Johnson, 105-119. Future Science, 2016.
    Publicado • 10.4155/fseb2013.14.182
  10. Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Quimioterapia combinada no tratamento do cancro: princípios e estratégias nanotecnológicas de entrega de fármacos". In Biomateriais aplicados ao desenvolvimento de sistemas terapêuticos avançados, editado por H.C. De Sousa; M.E.M. Braga; A. Sosnik, 675-700. Imprensa da Universidade de Coimbra, 2015.
    10.14195/978-989-26-0881-5_17
  11. Catarina, Ana; João Nuno Moreira; Simoes, Sergio. "Combination Chemotherapy in Cancer: Principles, Evaluation and Drug Delivery Strategies". In Current Cancer Treatment - Novel Beyond Conventional Approaches, editado por Öner Özdemir. InTech, 2011.
    Publicado • 10.5772/22656
  12. Moreira, João Nuno. "Moura V, Gomes da Silva LC, Fonseca NA, Pedroso de Lima MC, Simões S, Moreira JN, Emerging targets and novel nanotechnology-based strategies: changing the treatment paradigm in oncology.". In Brain Cancer, Tumor Targeting and Cervical Cancer, Elena K. Salvatti (Ed.), Nova Science Publishers (2011). ISBN: 978-1-61122-738-3., 39-74. 2011.
    Publicado
  13. Moreira, João Nuno; Santos, A.; Bimbo, L.M.; Gomes da Silva, L. C.; Pedroso de Lima, M. C.; Simões, S.. "Gene silencing therapy in small cell lung cancer – which agents, targets, and delivery systems?". In Small-Cell Carcinomas: Causes, Diagnosis, and Treatment, editado por Jonathon G. Maldonado; Mikayla K. Cervantes, 1-51. Nova Science Publishers, 2009.
    Publicado
Edição de livro
  1. Moreira, João Nuno. Current Applications of Pharmaceutical Biotechnology. Springer International Publishing. 2020.
    Publicado • 10.1007/978-3-030-40464-2
Poster em conferência
  1. Costa, CP; Cunha, S.; Moreira, João Nuno (EF1B-FA3D-0787); Sousa Loubo, JM; Silva, AC. "Optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach, Abstract nr 46". Trabalho apresentado em Virtual Vancouver Nanomedicine Day, 2020.
  2. C.P. Costa; S. Cunha; Moreira, João Nuno; M.H. Amaral; J.M. Sousa Lobo; A.C. Silva. "Optimization of lipid nanoparticles formulation for nose-to-brain delivery using the quality by design (QbD) approach". Trabalho apresentado em 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2020.
  3. Ribeiro, R.; Moreira, João Nuno; Gonçalves, J.. "Increasing the affinity of anti-nucleolin antibodies against triple negative breast cancer using a phage display approach". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  4. Abreu, Teresa; Fonseca, Nuno A.; Moreira, João Nuno. "Specific recognition of the onco-target nucleolin by the tumor homing F3 peptide". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  5. Biscaia-Caleiras, M.; Fonseca, Nuno A.; Cruz, A.F.; Gonçalves, N.; Moreira, João Nuno. "Targeted delivery of doxorubicin and C6-ceramide combinations to non-small cell lung cancer cells - Key factors for C6-ceramide's cytotoxicity". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  6. Cruz, A. F.; Fonseca, Nuno A.; Gonçalves, N.; Moura, V.; Simões, S.; Moreira, João Nuno. "Synergistic cytotoxicity of targeted liposomal C6-ceramide and doxorubicin against nucleolin-overexpressing cancer cells is supported by the downregulation of the PI3K/Akt pathway". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  7. Costa, C. P.; Cunha, S.; Moreira, João Nuno; Amaral, N. H.; Sousa Lobo, J. M.. "Hydrogel formulations containing nanostructured lipid carriers (NLC) and nanoemulsions (NE) for intranasal delivery of carbamazepine". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  8. Cruz, A. F.; Fonseca, Nuno A.; Gonçalves, N.; Moura, V.; Simões, S.; Moreira, João Nuno. "The Potential Of Liposomal C6-ceramide/doxorubicin Targeted To Nucleolin To Decrease Triple-negative Breast Cancer Stem Cell Population, Relative To A Standard Of Treatment". Trabalho apresentado em 2019 Controlled Release Society Annual Meeting, 2019.
  9. Costa, C. P.; Cunha, S.; Silva, A.C.; Amaral, M. H.; Sousa Lobo, J. M.; Moreira, João Nuno. "Development Of A Semi-solid Formulation For The Intranasal Delivery Of Carbamazepine By Means Of Lipid-based Nanosystems". Trabalho apresentado em 2019 Controlled Release Society Annual Meeting, 2019.
  10. Fonseca, Nuno A.; Gregório, A.C.; Mendes, V.; Lopes, R.; Manadas, B.; Lacerda, M.; Figueiredo, P.; et al. "Tumor intracellular bioavailability of doxorubicin determines therapeutic efficacy of nanoparticle targeted to nucleolin". Trabalho apresentado em 3rd ASPIC International Congress, 2018.
  11. C. Pechincha; Fonseca, Nuno A.; J. S. Ramalho; Moreira, João Nuno. "Nucleolin as a functional driver of breast cancer cells and a target for anti-cancer therapies". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  12. Cruz, A. F.; Fonseca, Nuno A.; Moura, V.; Simões, S.; Moreira, João Nuno. "Cytotoxicity of targeted liposomal C6-ceramide and doxorubicin against nucleolin-overexpressing cancer cell lines is supported by the downregulation of the Akt pathway and is more effective than conventional drug combinations". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  13. Romano, N.; Oliveira, A. R.; Moura, V.; Simões, S.; Moreira, João Nuno. "Engineering novel anti-nucleolin antibody fragments with antibody-dependent cell-mediated cytotoxicity". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  14. Gonçalves, N.; Fonseca, Nuno A.; Moreira, João Nuno. "Cell surface/cytoplasmic relative levels of nucleolin: a key feature for successful anticancer nanotherapies targeting nucleolin". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  15. Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Valerie LeBleu; Raghu Kalluri; Moreira, João Nuno. "Epigenetic unbalance may increase lung incidence in patients affected by idiopatic pulomonary fibrosis". Trabalho apresentado em ERS Conference, 2017.
  16. Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Valerie LeBleu; Moreira, João Nuno. "The presence of activated fibroblasts can explain the increase incidence of lung cancer after pulmonary fibrosis". Trabalho apresentado em ASPIC Conference, 2016.
  17. Balça-Silva, Joana; Moreira, João Nuno; do Carmo, Anália; Moura Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela. "Specific cellular association of liposomes by stem-like cells improves therapeutic efficacy in glioblastoma". Trabalho apresentado em Annual Meeting of Neuroscience, 2016.
  18. Mariangela Natale; Sylvia Vong; Michael Zeisberg; Lina Carvalho; Björn Tampe; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri. "Functional role of alfa smooth muscle actin positive cells in the pathogenesis of lung cancer". Trabalho apresentado em University of Germany, 2015.
  19. Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri. "Genome wide analysis of human lung cancer associated fibroblasts (CAFs): The functional contribution of alfa smooth muscle actin positive myofibroblasts in the initiation of lung cancer". Trabalho apresentado em MD Anderson Cancer Center, GAP Conference, 2015.
  20. Moreira, João Nuno; Gregório, A.C.; Fonseca, Nuno A.; Moura, V.; Domingues G.; Lacerda, M.; Figueiredo, P.; Simões, S.; Dias S.. "Targeting cell surface nucleolin in metastatic breast cancer". Trabalho apresentado em 1st ASPIC International Congress of the Portuguese Association for Cancer Research, 2014.
  21. Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri. "Cancer Associated Fibroblasts in the microenvironmet of lung cancer". Trabalho apresentado em Medimmune, 2014.
  22. Valério-Fernandes, Ângela; Fonseca, Nuno A.; Moura, Vera; Ladeirinha, Ana; Ferreira, Teresa; Alarcão, Ana; Carvalho, Lina; Simões, Sérgio; Moreira, João Nuno. "Nucleolin in lung cancer – an emerging target to overcome stroma-mediated anti-angiogenic resistance". Trabalho apresentado em 1st ASPIC International Congress, 2014.
  23. Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Santos-Rosa, Manuel; Moura, Vera; Ramalho-Santos, João; Simões, Sérgio; Moreira, João Nuno. "Nucleolin-mediated targeting of breast cancer cell subpopulations with different stem-like phenotype". Trabalho apresentado em 1st ASPIC International Congress, 2014.
  24. Valério-Fernandes, Â.; Fonseca, N.A.; Moura, V.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; et al. "Nucleolin-mediating targeting of the tumor microenvironment in bevacizumab-resistant Lung Cancer". Trabalho apresentado em Xth Spanish-Portuguese Conference on Controlled Drug Delivery: Drug Delivery Systems from Lab to Clinic – New Trends and Opportunities, 2013.
  25. Fonseca, Nuno A.; Simões, Sérgio; Moreira, João Nuno. "Rational design of synergistic drug combinations against breast cancer". Trabalho apresentado em EMBO Young Scientists’ Forum, 2013.
  26. Valério-Fernandes, Â.; Fonseca, Nuno A.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Simões, S.; Moreira, João Nuno. "Assessing the potential of nucleolin-targeted strategies against Lung Cancer resistant to anti-VEGF therapies". Trabalho apresentado em XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting -TRANSLATIONAL RESEARCH IN CANCER, 2013.
  27. Monteiro N.; Martins A.; Pires R.; Faria S.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Release of Bioactive Agent from Liposomes Immobilized on Electrospun Nanofibers Targeting Tissue Engineering Applications". Trabalho apresentado em Annual Meeting of the Society For Biomaterials, 2013.
  28. Monteiro N.; Martins A.; Ribeiro D.; Faria S.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "On the Use of Dexamethasone Loaded Liposomes to Induce the Osteogenic Differentiation of Human Mesenchymal Stem Cells". Trabalho apresentado em Annual Meeting of the Society For Biomaterials, 2013, 2013.
  29. Valério-Fernandes, Â.; Fonseca, Nuno A.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Moreira, João Nuno. "Targeted drug delivery to the tumor microenvronment in lung cancer". Trabalho apresentado em X Annual Meeting of the Center for Neuroscience and Cell Biology, 2012.
  30. Carvalho, J. F. S.; Jeremias, H.; Silva, M. M. C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Exploring the relevance of the oxysteril's C-6 and C-7 positions for cytotoxicity". Trabalho apresentado em 3rd Portuguese meeting on Medicinal Chemistry, 2012.
  31. Monteiro N. S.; Martins A.; Ribeiro D.; Pires R. A.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Release of growth factors from liposomes immobilized on electrospun nanofibers targeting tissue engineering applications". Trabalho apresentado em 3rd MIT-Portugal Program Conference, 2012.
  32. Figueiredo, S.; Rizzitelli, S.; Aime, S.; Geraldes, C.F.G.C.; Moreira, João Nuno. "Nature-inspired particles as carriers for multimodal molecular imaging applications". Trabalho apresentado em IEEE 2nd Portuguese Meeting In Bioengineering, 2012.
  33. Carvalho, J.F.S.; Jeremias, H.; Silva, M. M. C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Oxysterol as selective cytotoxic and chemosensitizer agents. Synthesis and cell proliferation studies". Trabalho apresentado em . III Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish Conference on Controlled Drug Delivery, 2011.
  34. Moura, V.; Figueiredo, P.; Corvo, M. L.; Cruz M. E.; Soares, R.; Pedroso de Lima, M.C.; Simões, S.; Moreira, João Nuno. "Targeted and triggered to the tumor microenviroment: impact on the treatment of solid tumors". Trabalho apresentado em Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish Conference on Controlled Drug Delivery, 2011.
  35. Fonseca A. R.; Alves, R.; Gonçalves, A. C.; Silva, L.; Alves, A.; Moreira, João Nuno; Sarmento-Ribeiro, A. B.. "RNAi induced down-regulation of FLT3 expression in Acute Myeloid Leukemia (AML) and increase sensitivity to the Proteasome Inhibitor, MG262". Trabalho apresentado em THE Young European Scientist Meeting (YES Meeting), 2011.
  36. Figueiredo, S.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.; Terreno, E.. "Gd-loaded yeast cell wall particles as an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Trabalho apresentado em Metal-Based Systems for Molecular Imaging Applications - Cost D38 Final Meeting, 2011.
  37. Figueiredo, S.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E.; Moreira, João Nuno. "Gd-loaded yeast cell wall particles as an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Trabalho apresentado em World Molecular Imaging Congress, 2011.
  38. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "Gd-loaded Yeast cell wall particles: an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Trabalho apresentado em 36th FEBS Congress, 2011.
  39. Pinto, A.C.; Moreira, João Nuno; Simões, S.. "Liposomal imatinib-mitoxantrone combination: formulation development and therapeutic evaluation in an animal model of prostate cancer". Trabalho apresentado em I Symposium on Nanoscience and Biomedical Nanotechnology, 2011.
  40. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "Yeast cell wall particles as highly sensitive MRI contrast agents". Trabalho apresentado em Metal-Based Systems for Molecular Imaging Applications - Joint Working Groups 2 and 6 meeting, 2011.
  41. Carvalho, J. F. S.; Silva, M.M.C.; Moreira, João Nuno; Simões, S.; Riva, S; Sá e Melo, M. L.. "Synthesis of a library of glycosyl and acyl glycosyl oxysterols, cytotoxic profile and SAR". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry - Portuguese Chemical Society (SPQ), 2010.
  42. Carvalho, J. F. S.; Silva, M.M.C.; Moreira, João Nuno; Simoes, S.; Sá e Melo M. L.. "Synthesis and cytotoxic evaluation of trihydroxysteroids". Trabalho apresentado em XXI International Symposium on Medicinal Chemistry, 2010.
  43. Figueiredo, S.; Cittadino, E.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Gd(III)-loaded liposomes as enzyme responsive MRI probes". Trabalho apresentado em 2010 World Molecular Imaging Congress, 2010.
  44. Moura, V.; Lacerda, M.; Figueiredo, P.; Corvo, M. L.; Cruz, M. E.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno. "Targeting non-viral vectors to tumor cells and the tumor micronvironment". Trabalho apresentado em 16th International Charles Heidelberger Symposium on Cancer Research, 2010.
    10.1186/1753-6561-4-s2-o26
  45. Gomes da Silva, L. C.; Ramalho, J.S.; De Lima, M.C.P.; Simões, S.; Moreira, João Nuno. "Targeted Gene Silencing for Cancer Treatment". Trabalho apresentado em The 16th International Charles Heidelberger Symposium on Cancer Research, 2010.
    10.1186/1753-6561-4-S2-P45
  46. Figueiredo, S.; Geraldes, C. F. G. C.; Moreira, João Nuno; Aime, S.. "MRI intelligent contrast agents as Enzyme Responsive Nanosystems". Trabalho apresentado em 5th European Molecular Imaging Meeting, 2010.
  47. Gomes-da-Silva, L.C.; Bimbo, L.; Santos, A.; Ramalho, J. S.; de Lima, M.C.P.; Simões, S.; Moreira, João Nuno. "Ligand-mediated targeted nanocarriers containing siRNA for cancer treatment". Trabalho apresentado em Keystone Symposia on Molecular and Cell Biology: New Paradigms in Cancer Therapeutics, 2010.
  48. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Paramagnetic liposomes as enzyme-responsive relaxometric agents". Trabalho apresentado em 8th Inorganic Chemistry Conference, 2009.
  49. Carvalho, J.F.S.; Silva, M.M.C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.; Carvalho, J. F. S.; Cruz Silva, M.M.. "Cytotoxic epoxysterols: chemoenzymatic synthesis, biological evaluation and SAR". Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, 2009.
  50. Figueiredo, S.; Cittadino, E.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "SMART MRI contrast agents: enzyme responsive Nanosystems". Trabalho apresentado em 2009 World Molecular Imaging Congress, 2009.
  51. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.. "Paramagnetic liposomes as enzyme-responsive relaxometric agents". Trabalho apresentado em 7th International Conference on f-Elements, 2009.
  52. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Paramagnetic liposomes as enzyme-responsive relaxometric agents". Trabalho apresentado em The 6th Conference on Field Cycling NMR Relaxometry, 2009.
  53. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "MRI intelligent contrast agents: enzyme responsive nanosystems". Trabalho apresentado em Meditrans Second Annual Meeting, 2009.
  54. Firmino, F.; Mendonça, L.S.; Moreira, João Nuno; Pedroso De Lima, M.C.; Simões, S.. "Delivery of asODNs to chronic myeloid leukaemia by transferrin receptor targeted liposomes". Trabalho apresentado em 7th Congress of the Portuguese-Spanish Chapter of the Controlled Release Society, 2008.
  55. Carvalheiro, M.; Moreira, João Nuno; Simões, S.; Cruz, M.E.M.. "Targeted delivery of c-myc antisense oligodeoxynucleotide to SCLC mediated by novel lipidc vesicles". Trabalho apresentado em First Internal Meeting of iMed.UL, 2008.
  56. Pinto, A.C.; Ângelo, S.; Moreira, João Nuno; Simões, S.. "Individual or co-encapsulated liposomal Imatinib-mitoxantrone combination for hormone-refractory prostate cancer therapy". Trabalho apresentado em 7th Congress of the Portuguese-Spanish Chapter of the Controlled Release Society, 2008.
  57. Santos, A.; Pereira, J.P.; Sarmento-Ribeiro, A.B.; Simões, S.; Pedroso de Lima, M. C.; Moreira, João Nuno. "Targeted therapeutics in SCLC – BCL2 revisited". Trabalho apresentado em Annual Meeting of the Center for Neuroscience and Cell Biology, 2007.
  58. Colla, M.; Moreira, João Nuno; Simões, S.. "Targeted delivery of c-Myc antisense oligodeoxynucleotide mediated by novel lipidic vesicles". Trabalho apresentado em 1st European Science Foundation Summer School in Nanomedicine, 2007.
  59. Fonseca, C.; Mendonça, L.; Moreira, João Nuno; Cabrita, A.; Paiva, A.; Lopes, M. T.; Pedroso de Lima, M.C.; Simões, S.. "Novel nanobiotechnology-based approaches for gene silencing: in vitro and in vivo evaluation for the treatment of human acute lymphoblastic leukemia". Trabalho apresentado em Encontro da Associação Nacional de Farmácias, 2007.
  60. Pedroso de Lima, M. C.; Moura, V.; Simões, S.; Moreira, João Nuno. "Targeting stealth liposomes to human breast cancer cells with a vasculature-homing peptide". Trabalho apresentado em Annual Meeting of the Center for Neuroscience and Cell Biology, 2006.
  61. Santos, A.; Zangemeister-Wittke, U.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno. "Targeted downregulation of the BCL2 oncogene: a promising therapeutic strategy against small cell lung cancer". Trabalho apresentado em 7th Congress of the Portuguese-Spanish Chapter of the Controlled Release Society, 2006.
  62. Carvalho, J. F. S.; Silva, M.M.C.; Marques, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Oxysterols as potential anticancer agents. Synthesis and biological evaluation". Trabalho apresentado em Medicinal Chemistry in the 21st Century, 2006.
  63. Colla, M.; Moreira, João Nuno; Simões, S.; Cruz, M. E.. "Antagonist G targeted stabilized antisense-lipid particles (SALP-G): a novel vector for delivery of antisense oligonucleotides to small cell lung cancer". Trabalho apresentado em 7th Congress of the Portuguese-Spanish Chapter of the Controlled Release, 2006.
  64. Moreira, João Nuno; Pinto, A. C.; Simões, S.. "Ciprofloxacin and imatinib sensitize hormone-refractory prostate cancer cells to conventional cytotoxic agents in a schedule-dependent manner". Trabalho apresentado em ACR Special Conference in Cancer Research - Innovations in prostate cancer research, 2006.
  65. Santos, A.; Zangemeister-Wittke, U.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno. "Antisense oligonucleotide-containing liposomes targeted to growth fator receptors in small cell lung cancer". Trabalho apresentado em International Liposome Society 2005 – Annual Meeting – Liposome Advances: Progress in Drug and Vaccine Delivery, 2005.
  66. Santos, A.; Zangemeister-Wittke, U.; Pedroso de Lima, M. C.; Simões, S.; Moreira, João Nuno. "Antagonist G peptide mediated uptake of liposomes containing bcl-2 antisense oligonucleotides in small cell lung cancer cells". Trabalho apresentado em Joint Annual Meeting of Graduate Programmes in Biosciences, 2005.
  67. Santos, A.; Simões, S.; Pedroso de Lima, M. C.; Moreira, João Nuno. "Novel targeted non-viral lipid-based vector for the treatment of human small cell lung cancer: intracellular delivery of antisense oligonucleotides". Trabalho apresentado em 2nd Congress of the Portuguese Society of Pharmaceutical Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled Release Society, 2005.
  68. Carvalho, J.F.S.; Cruz Silva, M. M. C.; Marques, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Cytotoxic activity of a library of synthetic sterols". Trabalho apresentado em 2nd Congress of the Portuguese Society of Pharmaceutical Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled Release, 2005.
  69. Fonseca, C.; Moreira, João Nuno; de Lima, M.C.P.; Simões, S.. "Targeted delivery and pH-triggered release of antisense oligonucleotides mediated by novel liposome formulations". Trabalho apresentado em 2nd Congress of the Portuguese Society of Pharmaceutical Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled Release, 2005.
  70. Santos, A.; Simões, S.; Pedroso De Lima, M.C.; Moreira, João Nuno. "Targeted antisense therapy: a novel approach for the treatment of small cell lung cancer". Trabalho apresentado em Joint Annual Meeting of Graduate Programmes in Biosciences, 2004.
  71. Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.; Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium". Trabalho apresentado em IV Congresso de Investigação em Medicina, 2004.
  72. Fonseca, C.; Moreira, João Nuno; Ciudad, C.; Pedroso de Lima, M. C.; Simões, S.. "Efficient intracellular delivery of antisense oligonucleotides to human T-leukemia cells mediated by targeted sterically stabilized pH-sensitive liposomes". Trabalho apresentado em 12th Annual Congress of the European Society of Gene Therapy, 2004.
  73. Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.; Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium". Trabalho apresentado em 9th Annual Meeting of the American Society of Nuclear Cardiology, 2004.
  74. Carvalho, J. F. S.; Neves, M. A. C.; Filipe, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Antitumor activity of a library of synthetic sterols". Trabalho apresentado em XVIIth International Symposium on Medicinal Chemistry, 2004.
  75. Cruz Silva, M.M.; Carvalho, J.F.S.; Neves, M. A. C.; Filipe, A.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Synthesis of polyhydroxysteroids and cytotoxic evaluation on HeLa cells". Trabalho apresentado em 19th National Meeting of the Portuguese Society of Chemistry, 2004.
  76. Fonseca, C.; Moreira, João Nuno; Ciudad, C.; Pedroso de Lima, M. C.; Simões, S.. "Novel formulations of targeted pH-sensitive liposomes bearing poly(ethylene glycol) as carriers for antisense oligonucleotides". Trabalho apresentado em 5th International Conference on Liposome Advances: Progress in Drug and Vaccine Delivery, 2003.
  77. Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.; Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium – Preliminary results". Trabalho apresentado em Annual Congress of European Association of Nuclear Medicine, 2003.
  78. Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Gonçalves, L.; Providência, L. A.. "Desenvolvimento de lipossomas com afinidade para as áreas miocárdicas isquémicas". Trabalho apresentado em IX Congresso Nacional de Medicina Nuclear, 2002.
  79. Fonseca, C.; Moreira, João Nuno; De Lima, M.C.P.; Simões, S.. "Novel formulations of targeted pH-sensitive liposomes bearing poly)(ethylene glycol". Trabalho apresentado em V Spanish-Portuguese Conference on Controlled Drug Delivery, 2002.
  80. Moreira, João Nuno; Gaspar, R.; Allen, T.M.. "In vivo targeting of Stealth liposomes against human small cell lung cancer". Trabalho apresentado em 8th Liposome Research Days Conference, 2002.
  81. Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D.. "Adventures in targeting". Trabalho apresentado em 5th International Conference on Liposome Advances: Progress in Drug and Vaccine, 2001.
  82. Fonseca, C.; Moreira, João Nuno; Pedroso De Lima, M.C.; Simões, S.. "Development of novel formulations of targeted sterically stabilized pH-sensitive liposomes". Trabalho apresentado em 5th International Conference on Liposome Advances: Progress in Drug and Vaccine Delivery, 2001.
  83. Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Post-insertion of peptide ligands into pre-formed stealth® liposomes with retention of binding activity and cytotoxicity". Trabalho apresentado em 27th Meeting of the Federation of European Biochemical Societies, 2001.
  84. Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Imobilização à superfície de lipossomas de moléculas terapeuticamente activas: aumento da sua afinidade para receptores celulares específicos". Trabalho apresentado em Segundas Jornadas da Sociedade Portuguesa de Ciências Farmacêuticas, 2001.
  85. Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Lipossomas no transporte específico de doxorrubicina em terapia anti-tumoral". Trabalho apresentado em VII National Symposium of the Portuguese Association of Hospitalar Pharmacists, 2000.
  86. Moreira, João Nuno; Hansen, C.B.; Gaspar, R.; Allen, T.M.. "Pharmacokinetic properties and biodistribution of hexapeptide-targeted Stealth® liposomes". Trabalho apresentado em IV Spanish-Portuguese Conference Controlled Drug Delivery, 2000.
  87. Moreira, João Nuno; Kirchmeier, M.; Gaspar, R.; Allen, T.M.. "Intracellular trafficking of hexapeptide-targeted Stealth liposomal doxorubicin in a classical small cell lung cancer cell line". Trabalho apresentado em 7th Liposome Research Days Conference, 2000.
  88. Moreira, João Nuno; Hansen, C.B.; Gaspar, R.; Allen, T.M.. "In vitro targeting of poly(ethylene glycol)-grafted liposomes by hexapeptide to a classical small cell lung cancer cell line". Trabalho apresentado em 26th International Symposium on Controlled Release of Bioactive Materials, 1999.
  89. Botelho, M. F.; Pedroso de Lima, J. J.; Dormehl, I. C.; Moreira, João Nuno; Santos, A. C.; Gomes, C. M.; Baganha, M. F.. "Visualização de drenagem linfática através da inalação de lipossomas marcados". Trabalho apresentado em Congresso de Pneumologia, 1998.
  90. Botelho, M. F.; Moreira, João Nuno; Santos, A. C.; Gomes, C.; Gaspar, R.; Pedroso de Lima, J. J.. "Visualização linfática por simulação da biodistribuição de bacilos com radiolipossomas". Trabalho apresentado em III Congress of the Controlled Release Society, Spanish-Portuguese Local Chapter (SPLC-CRS), 1998.
  91. Gaspar, R.; Simões, S.; Moreira, João Nuno; Pereira de Almeida, L.; Alfar, S. C. F.; Gameiro, S.. "Drug targeting strategies with colloidal carriers: an integrated approach for therapeutic innovation". Trabalho apresentado em 1st Meeting on Opportunities for Pharmaceutical R&D in Portugal, 1998.
  92. Moreira, João Nuno; Hansen, C. B.; Allen, T.M.; Gaspar, R.. "Carboplatin encapsulation in sterically stabilized liposomes". Trabalho apresentado em 12th Annual Meeting of Groupe Tematique de Recherche sur les Vecteures, 1997.
  93. Moreira, João Nuno; Almeida, L.M.; Madeira, V.M.C.; Costa, M.L.. "In vitro characterization of O-palmitoylpullulan coated large unilamellar liposomes containing carboplatin". Trabalho apresentado em 1st Spanish-Portuguese Conference on Controlled Drug Delivery, 1995.
  94. Moreira, João Nuno; Almeida, L.M.; Geraldes, C.F.; Costa, M. L.. "Improvement of in vitro stability of liposomes by coating with a modified polysaccharide (O-palmitoylpullulan)". Trabalho apresentado em 12th European Conference on Biomaterials, 1995.
  95. Veiga, F.; Simões, S.; Moreira, João Nuno; Sousa, A.. "Evaluation of the in vitro dissolution of some commercial sustained release theophylline dosage forms". Trabalho apresentado em 11th Conference on Pharmaceutical Technology, 1992.
Prefácio / Posfácio
  1. Ana Catarina Silva; Moreira, João Nuno; Sousa Lobo, José Manuel; Hugo Almeida. "Preface: Current Applications of Pharmaceutical Biotechnology". Prefácio para Current Applications of Pharmaceutical Biotechnology, editado por Ana Catarina Silva; Moreira, João Nuno; Sousa Lobo, José Manuel; Almeida, Hugo. Springer International Publishing. 2020.
    Publicado
Tese / Dissertação
  1. Moreira, João Nuno. "Targeting of liposomes to human small cell lung cancer". Doutoramento, Universidade de Coimbra Faculdade de Farmácia, 2001.
  2. Moreira, João Nuno. "Characterization of carboplatin-containing liposomes coated with O-palmitoylpullulan". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1994.

Propriedade Intelectual

Patente
  1. Fonseca, Nuno A.; Moura, Vera; Gregório, A.C.; Simões, Sérgio; Moreira, João Nuno. 2019. "Nanodelivery tissue targeting at low systemic exposures and methods thereof (PCT/PT2019/050034)".
    Pendente
  2. Moreira, João Nuno; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões. 2018. "Ph-sensitive liposome binding to nucleolin (Granted, EP2291199)".
    Concedida/Emitida
  3. Nuno A. Fonseca; Gomes-da-Silva, L.C.; Vera Moura; Sérgio Simões; Moreira, João Nuno. 2018. "Platform for targeted delivery to stem cells and tumor cells and methods thereof (Granted - EP2983720)".
    Concedida/Emitida
  4. Moreira, João Nuno; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões. 2014. "Targeted delivery to human diseases and disorders (Granted - US Patent 8,741,338)". Estados Unidos.
    Concedida/Emitida
  5. Moreira, João Nuno. 2013. "Targeted delivery to human diseases and disorders (Granted - US Patent 8,529,944)".
  6. Moreira, João Nuno. 2012. "Targeted delivery to human diseases and disorders (Granted - US Patent 8,231,895)".
  7. Moreira, João Nuno; Silva, L.; Santos, A.O.; Bimbo, L.; Pedroso de Lima, M.C.; Simões, S.. 2011. "F3-peptide targeted lipid-based nanoparticles useful for the treatment of angiogenesis-dependent diseases (PCT/PT2011/000008)". Portugal.
    Pendente
  8. Mendonça, L.; Moreira, João Nuno; Pedroso de Lima, M.C.; Simões, S.. 2011. "Triple targeting with a single therapeutic system (PCT/PT2011/000005)". Portugal.
    Pendente
Pedido provisório de patente
  1. 2020. "Moreira JN, Simões S, Fonseca N, Moura V, Cruz A, “Overcoming drug resistance associated with cancer stem cells and methods thereof” Portuguese Provisional Patent Application 116 084 B.".
    Divulgado
  2. 2018. "Fonseca N, Moura V, Gregório AC, Lopes RM., Simões S, Moreira JN, “Nucleolin-mediated intracellular drug release inhibits tumor growth at low systemic exposure” Portuguese Provisional Patent Application No 115032.".
  3. 2017. "Moreira, JN; Romano, S; Moura, V; Simões, S; Gonçalves, J. “Anti-nucleolin antibody”, Portuguese Provisional Patent Application No. 110214".
    Divulgado

Outros

Empresa spin-off
  1. 2010. TREAT U, Lda (Co-founder). Oncology. http://treatu.pt/.
Distinções

Prémio

2013 Best Poster presentation of the Translational and Clinical Research panel (XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting)
2012 Best Poster presentation - "Poster E2: Targeted drug delivery to the tumor microenvronment in lung cancer"
X Annual Meeting of the Center for Neuroscience and Cell Biology and Doctoral Programme in Experimental Biology and Biomedicine, Portugal
2012 João Nuno Moreira's research group was recognized by its activity on breast cancer
2011 2010 Education Innovation Awards
2011 Best Poster presentation- "Liposomal imatinib-mitoxantrone combination: formulation development and therapeutic evaluation in an animal model of prostate cancer"
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2011 Best Oral communication - "Design of anti-PLK1 siRNA-containing liposomes and targeted to cancer cells and the tumor microenvironment"
IX Spanish Conference on Controlled Drug Delivery, Portugal
2011 Best PhD thesis Award for the thesis "Vetorização de fármacos para os vasos sanguíneos tumorais - uma nova terapia para o cancro da mama humano" written by Vera Moura, with supervision of JN Moreira
Controlled Release Society, Estados Unidos
2010 Second place in the "Idea to Product I2P 2010" contest (5000 euros award)
COTEC Portugal , Portugal
2009 Best business idea with the technology "SMART MEDICINES”
ARRISCA COIMBRA 2009, Portugal
2008 Best Oral communication - "Smart nanomedicines for cancer"
MedTech Europe, Bélgica
2007 Best Poster presentation - “Novel nanobiotechnology-based approaches for gene silencing: in vitro and in vivo evaluation for the treatment of human acute lymphoblastic leukemia"”.
Ordem dos Farmaceuticos, Portugal
2002 Best Oral communication - "Novel formulations of targeted pH-sensitive liposomes bearing poly(ethylene glycol)"
Controlled Release Society, Estados Unidos

Outra distinção

2004 Bial Award 2004 (Honourable Mention) fo the work entitled "Desenvolvimento de lipossomas com afinidade para áreas miocárdicas isquémicas"
Fundação Bial, Portugal