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Postic Catherine. Completed the Doktor (PhD) in PhD in Physiology and Pathophysiology in 1993 by Université de Paris. Published 77 articles in journals. Has received 1 awards and/or honors.
Identificação

Identificação pessoal

Nome completo
Postic Catherine

Nomes de citação

  • Catherine, Postic

Identificadores de autor

Ciência ID
EB1A-AF07-F2E0
ORCID iD
0000-0002-1875-6960

Telefones

Telemóvel
  • (+33) 0685849052 (Pessoal)

Moradas

  • Institut Cochin Inserm U1016 24 rue du Faubourg saint Jacques, 75014, Paris, Paris, França (Profissional)
Formação
Grau Classificação
1989 - 1993
Concluído
PhD in Physiology and Pathophysiology (Doktor (PhD))
Université de Paris, França
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
1997 - Atual Investigador principal (carreira) (Investigação) Centre National de la Recherche Scientifique, França
Institut Cochin de Génétique Moléculaire, França
1993 - 2000 Estagiário de Investigação (Investigação) Vanderbilt University, Estados Unidos
Vanderbilt University, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2017 - 2021 HEPADIALOG : Impact of Fatty Acid Metabolism in Adipose Tissues and Liver on Insulin Resistance
ANR-HEPADIALOG
Investigador
Agence nationale de la recherche, França
Em curso
2017 - 2021 LYSODIABETES : Nutrient-dependent lysosomal functions in type 2 diabetes
ANR-LYSODIABETES
Investigador
Agence nationale de la recherche, França
Em curso
2017 - 2021 IRONASH : Role of iron in the pathogenesis of NASH
ANR-IRONASH
Investigador
Agence nationale de la recherche, França
Em curso
Produções

Publicações

Artigo em revista
  1. Catherine, Postic. "Sweet Sixteenth for ChREBP: Established Roles and Future Goals.". Cell metabolism (2017): http://europepmc.org/abstract/med/28768172.
    10.1016/j.cmet.2017.07.004
  2. Catherine, Postic. "Insights into the role of hepatocyte PPARa activity in response to fasting.". Molecular and cellular endocrinology (2017): http://europepmc.org/abstract/med/28774777.
    10.1016/j.mce.2017.07.035
  3. Catherine, Postic. "MondoA/ChREBP: The usual suspects of transcriptional glucose sensing; Implication in pathophysiology.". Metabolism: clinical and experimental (2017): http://europepmc.org/abstract/med/28403938.
    10.1016/j.metabol.2017.01.033
  4. Catherine, Postic. "Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma.". Hepatology (Baltimore, Md.) (2017): http://europepmc.org/abstract/med/27981611.
    10.1002/hep.28972
  5. Catherine, Postic. "Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling.". PloS one (2017): http://europepmc.org/abstract/med/28732092.
    10.1371/journal.pone.0181393
  6. Catherine, Postic. "Emerging role of miR-21 in non-alcoholic fatty liver disease.". Gut (2016): http://europepmc.org/abstract/med/27436271.
    10.1136/gutjnl-2015-310044
  7. Catherine, Postic. "Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance.". Molecular and cellular biology (2016): http://europepmc.org/abstract/med/27215388.
    10.1128/mcb.00170-16
  8. Catherine, Postic. "Liver PPARa is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.". Gut (2016): http://europepmc.org/abstract/med/26838599.
    10.1136/gutjnl-2015-310798
  9. Catherine, Postic. "Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth.". Oncogene (2016): http://europepmc.org/abstract/med/26300003.
    10.1038/onc.2015.283
  10. Catherine, Postic. "Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch.". Scientific reports (2016): http://europepmc.org/abstract/med/27126782.
    10.1038/srep25140
  11. Catherine, Postic. "Therapeutic potential of nicotinamide adenine dinucleotide for nonalcoholic fatty liver disease.". Hepatology (Baltimore, Md.) (2016): http://europepmc.org/abstract/med/26661503.
    10.1002/hep.28383
  12. Catherine, Postic. "Corrigendum: Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch.". Scientific reports (2016): http://europepmc.org/abstract/med/27243941.
    10.1038/srep26916
  13. Catherine, Postic. "Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism.". Physiology (2015): http://europepmc.org/abstract/med/26525342.
    10.1152/physiol.00016.2015
  14. Catherine, Postic. "Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking.". Hepatology (Baltimore, Md.) (2015): http://europepmc.org/abstract/med/25761756.
    10.1002/hep.27778
  15. Catherine, Postic. "Hepatokines: unlocking the multi-organ network in metabolic diseases.". Diabetologia (2015): http://europepmc.org/abstract/med/26032022.
    10.1007/s00125-015-3634-4
  16. Catherine, Postic. "Gastric bypass surgery in NASH: a major modulator of hepatic mitochondrial dysfunction.". Gut (2015): http://europepmc.org/abstract/med/25080449.
    10.1136/gutjnl-2014-307738
  17. Catherine, Postic. "O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing.". Frontiers in Endocrinology (2014): http://europepmc.org/abstract/med/25628602.
    10.3389/fendo.2014.00230
  18. Catherine, Postic. "Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.". Molecular and cellular biology (2013): http://europepmc.org/abstract/med/23530060.
    10.1128/mcb.01004-12
  19. Catherine, Postic. "Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.". Journal of hepatology (2013): http://europepmc.org/abstract/med/23333450.
    10.1016/j.jhep.2013.01.006
  20. Catherine, Postic. "Novel insights into ChREBP regulation and function.". Trends in endocrinology and metabolism: TEM (2013): http://europepmc.org/abstract/med/23597489.
    10.1016/j.tem.2013.01.003
  21. Catherine, Postic. "[The transcription factor ChREBP: a key modulator of insulin sensitivity?].". Medecine sciences : M/S (2013): http://europepmc.org/abstract/med/24005632.
    10.1051/medsci/2013298016
  22. Catherine, Postic. "LRH-1-dependent glucose sensing determines intermediary metabolism in liver.". The Journal of clinical investigation (2012): http://europepmc.org/abstract/med/22772466.
    10.1172/jci62368
  23. Catherine, Postic. "Hidden variant of ChREBP in fat links lipogenesis to insulin sensitivity.". Cell metabolism (2012): http://europepmc.org/abstract/med/22682219.
    10.1016/j.cmet.2012.05.007
  24. Catherine, Postic. "The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans.". Journal of Clinical Investigation (2012): http://europepmc.org/abstract/med/22546860.
    10.1172/jci41636
  25. Catherine, Postic. "Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver.". Journal of hepatology (2012): http://europepmc.org/abstract/med/21835137.
    10.1016/j.jhep.2011.07.019
  26. Catherine, Postic. "Cross-regulation of hepatic glucose metabolism via ChREBP and nuclear receptors.". Biochimica et biophysica acta (2011): http://europepmc.org/abstract/med/21453770.
    10.1016/j.bbadis.2011.03.015
  27. Catherine, Postic. "Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes.". Journal of hepatology (2011): http://europepmc.org/abstract/med/21145868.
    10.1016/j.jhep.2010.10.024
  28. Catherine, Postic. "O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver.". Diabetes (2011): http://europepmc.org/abstract/med/21471514.
    10.2337/db10-0452
  29. Catherine, Postic. "Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice.". The Journal of clinical investigation (2010): http://europepmc.org/abstract/med/21084751.
    10.1172/jci41624
  30. Catherine, Postic. "Little caves ameliorate hepatic insulin signaling. Focus on "caveolin gene transfer improves glucose metabolism in diabetic mice".". American Journal of Physiology - Cell Physiology (2010): http://europepmc.org/abstract/med/20032514.
    10.1152/ajpcell.00542.2009
  31. Catherine, Postic. "Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor I kappa B alpha.". Molecular genetics and metabolism (2009): http://europepmc.org/abstract/med/19299176.
    10.1016/j.ymgme.2009.02.005
  32. Catherine, Postic. "The role of the lipogenic pathway in the development of hepatic steatosis.". Diabetes & metabolism (2008): http://europepmc.org/abstract/med/19195625.
    10.1016/s1262-3636(08)74599-3
  33. Catherine, Postic. "The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways.". Molecular and cellular biology (2008): http://europepmc.org/abstract/med/18765640.
    10.1128/mcb.02211-07
  34. Catherine, Postic. "[Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP].". Medecine sciences : M/S (2008): http://europepmc.org/abstract/med/18950580.
    10.1051/medsci/20082410841
  35. Catherine, Postic. "Carbohydrate responsive element binding protein and lipid homeostasis.". Current opinion in lipidology (2008): http://europepmc.org/abstract/med/18460923.
    10.1097/mol.0b013e3282ffafaa
  36. Catherine, Postic. "ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver.". The Journal of clinical investigation (2008): http://europepmc.org/abstract/med/18292813.
    10.1172/jci34314
  37. Catherine, Postic. "Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice.". Journal of Clinical Investigation (2008): http://europepmc.org/abstract/med/18317565.
    10.1172/jci34275
  38. Catherine, Postic. "Role of ChREBP in hepatic steatosis and insulin resistance.". FEBS letters (2008): http://europepmc.org/abstract/med/17716660.
    10.1016/j.febslet.2007.07.084
  39. Catherine, Postic. "[The regulation of gene expression by glucose].". Journal de la Societe de biologie (2007): http://europepmc.org/abstract/med/17978749.
    10.1051/jbio:2007020
  40. Catherine, Postic. "[Apollinare Bochardat Prize 2007. Regulation and glucose signal transduction in the liver: implication of the transcription factor CHREBP]". Journees annuelles de diabetologie de l'Hotel-Dieu (2007): http://europepmc.org/abstract/med/18610766.
  41. Catherine, Postic. "ChREBP, a transcriptional regulator of glucose and lipid metabolism.". Annual review of nutrition (2007): http://europepmc.org/abstract/med/17428181.
    10.1146/annurev.nutr.27.061406.093618
  42. Catherine, Postic. "Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.". Diabetes (2006): http://europepmc.org/abstract/med/16873678.
    10.2337/db06-0200
  43. Catherine, Postic. "Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBP.". The Journal of nutrition (2006): http://europepmc.org/abstract/med/16614395.
  44. Catherine, Postic. "Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.". Journal of Clinical Investigation (2005): http://europepmc.org/abstract/med/16322793.
    10.1172/jci25764
  45. Catherine, Postic. "Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation.". The Journal of clinical investigation (2005): http://europepmc.org/abstract/med/16184193.
    10.1172/jci25256
  46. Catherine, Postic. "Overexpression of beta2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes.". American journal of physiology. Endocrinology and metabolism (2005): http://europepmc.org/abstract/med/15585594.
    10.1152/ajpendo.00113.2004
  47. Catherine, Postic. "Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver.". Biochimie (2005): http://europepmc.org/abstract/med/15733741.
    10.1016/j.biochi.2004.11.008
  48. Catherine, Postic. "Role of the liver in the control of carbohydrate and lipid homeostasis.". Diabetes & metabolism (2004): http://europepmc.org/abstract/med/15671906.
    10.1016/s1262-3636(07)70133-7
  49. Catherine, Postic. "Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.". The Journal of biological chemistry (2004): http://europepmc.org/abstract/med/14985368.
    10.1074/jbc.m312475200
  50. Catherine, Postic. "Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice.". Endocrinology (2004): http://europepmc.org/abstract/med/14684612.
    10.1210/en.2003-0882
  51. Catherine, Postic. "Mouse models of insulin resistance and type 2 diabetes.". Annales d'endocrinologie (2004): http://europepmc.org/abstract/med/15122092.
    10.1016/s0003-4266(04)95630-2
  52. Catherine, Postic. "Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.". Diabetes (2001): http://europepmc.org/abstract/med/11246883.
    10.2337/diabetes.50.3.622
  53. Catherine, Postic. "Cell-specific roles of glucokinase in glucose homeostasis.". Recent progress in hormone research (2001): http://europepmc.org/abstract/med/11237213.
    10.1210/rp.56.1.195
  54. Catherine, Postic. "Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism.". Molecular and cellular biology (2000): http://europepmc.org/abstract/med/10938127.
    10.1128/mcb.20.17.6508-6517.2000
  55. Catherine, Postic. "Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.". Molecular cell (2000): http://europepmc.org/abstract/med/10949030.
    10.1016/s1097-2765(00)00010-1
  56. Catherine, Postic. "Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.". Molecular and cellular biology (2000): http://europepmc.org/abstract/med/10825207.
    10.1128/mcb.20.12.4436-4444.2000
  57. Catherine, Postic. "Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas.". Genesis (New York, N.Y. : 2000) (2000): http://europepmc.org/abstract/med/10686610.
    10.1002/(sici)1526-968x(200002)26:2<139::aid-gene12>3.0.co;2-7
  58. Catherine, Postic. "DNA excision in liver by an albumin-Cre transgene occurs progressively with age.". Genesis (New York, N.Y. : 2000) (2000): http://europepmc.org/abstract/med/10686614.
    10.1002/(sici)1526-968x(200002)26:2<149::aid-gene16>3.0.co;2-v
  59. Catherine, Postic. "Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites.". Molecular and cellular endocrinology (1999): http://europepmc.org/abstract/med/10221772.
    10.1016/s0303-7207(98)00234-2
  60. Catherine, Postic. "Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.". Cell (1999): http://europepmc.org/abstract/med/10025399.
    10.1016/s0092-8674(00)80546-2
  61. Catherine, Postic. "Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.". The Journal of biological chemistry (1999): http://europepmc.org/abstract/med/9867845.
    10.1074/jbc.274.1.305
  62. Catherine, Postic. "Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion.". The Journal of biological chemistry (1999): http://europepmc.org/abstract/med/9873043.
    10.1074/jbc.274.2.1000
  63. Catherine, Postic. "[Role of glucokinase (GK) in the maintenance of glucose homeostasis. Specific disruption of the gene by the Cre-loxP technique]". Journees annuelles de diabetologie de l'Hotel-Dieu (1999): http://europepmc.org/abstract/med/10732411.
  64. Catherine, Postic. "Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene.". Genomics (1997): http://europepmc.org/abstract/med/9339375.
    10.1006/geno.1997.4936
  65. Catherine, Postic. "Cell-specific expression and regulation of a glucokinase gene locus transgene.". The Journal of biological chemistry (1997): http://europepmc.org/abstract/med/9278410.
    10.1074/jbc.272.36.22564
  66. Catherine, Postic. "Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism.". The Journal of biological chemistry (1997): http://europepmc.org/abstract/med/9278411.
    10.1074/jbc.272.36.22570
  67. Catherine, Postic. "Effects of altered glucokinase gene copy number on blood glucose homoeostasis.". Biochemical Society transactions (1997): http://europepmc.org/abstract/med/9056854.
    10.1042/bst0250113
  68. Catherine, Postic. "Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites.". Genomics (1995): http://europepmc.org/abstract/med/8575768.
    10.1006/geno.1995.9943
  69. Catherine, Postic. "Development and regulation of glucose transporter and hexokinase expression in rat.". The American journal of physiology (1994): http://europepmc.org/abstract/med/8178975.
  70. Catherine, Postic. "Influence of the weaning diet on the changes of glucose metabolism and of insulin sensitivity.". The Proceedings of the Nutrition Society (1993): http://europepmc.org/abstract/med/8234354.
    10.1079/pns19930068
  71. Catherine, Postic. "Evidence for a transient inhibitory effect of insulin on GLUT2 expression in the liver: studies in vivo and in vitro.". Biochemical Journal (1993): http://europepmc.org/abstract/med/8328952.
    10.1042/bj2930119
  72. Catherine, Postic. "The effects of hyperinsulinemia and hyperglycemia on GLUT4 and hexokinase II mRNA and protein in rat skeletal muscle and adipose tissue.". Diabetes (1993): http://europepmc.org/abstract/med/8495814.
    10.2337/diab.42.6.922
  73. Catherine, Postic. "[Glucose transporters. Physiology and physiopathology].". Presse medicale (Paris, France : 1983) (1992): http://europepmc.org/abstract/med/1294980.
  74. Catherine, Postic. "[Glucose transport in different physiological situations (development, nutrition, exercise)]". Journees annuelles de diabetologie de l'Hotel-Dieu (1992): http://europepmc.org/abstract/med/1495228.
  75. Catherine, Postic. "Nutritional regulation of glucose transporter in muscle and adipose tissue of weaned rats.". The American journal of physiology (1991): http://europepmc.org/abstract/med/2018122.
  76. Catherine, Postic. "Adaptations of glucose metabolism in white-fat adipocytes at weaning in the rat are concomitant with specific gene expression.". Biochemical Society transactions (1990): http://europepmc.org/abstract/med/1982097.
    10.1042/bst0180857
  77. Catherine, Postic. "Glucose transporter expression in rat mammary gland.". Biochemical Journal (1990): http://europepmc.org/abstract/med/2396989.
    10.1042/bj2700277
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2011 - 2014 Role of the transcription factor ChREBP in the transcriptional regulation by glucose of the genes of glycolysis and lipogenesis in the liver: implication in the pathophysiology of obesity and / or type 2 diabetes
Orientador
Université de Paris, França
2009 - 2013 ChREBP and the control of hepatic lipogenesis: interrelation with nuclear receptors and insulin signaling
Orientador
Université de Paris, França
2006 - 2009 Role of the nuclear receptor LXR and glucagon in the regulation of the transcription factor ChREBP: implication in the development of hepatic steatosis and insulin resistance
Orientador
Université de Paris, França

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2015 - Atual Cell Reports Cell Press
2015 - Atual Gut (1468-3288) BMJ
2008 - Atual Journal of Clinical Investigation (1558-8238) American Society for Clinical Investigation

Membro de associação

Nome da associação Tipo de participação
2018 - Atual Association pour la recherche sur le Foie (AFEF) Association member
2008 - Atual Société Francophone du Diabète Association member

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2019 - 2022 Scientific board member of the "Fondation pour la recherche Médicale" A french research foundation
Membro
Fondation pour la Recherche Médicale, França
Distinções

Prémio

2015 Prize for Innovative Research (CNRS Silver Medal)
Centre National de la Recherche Scientifique, França